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Editorial: The 2nd Asia Pacific International Religious Tourism And Pilgrimage Conference (Apirtp), Darius Liutikas, Imam Wahyudi Karimullah, Sonny Elfiyanto Jun 2025

Editorial: The 2nd Asia Pacific International Religious Tourism And Pilgrimage Conference (Apirtp), Darius Liutikas, Imam Wahyudi Karimullah, Sonny Elfiyanto

International Journal of Religious Tourism and Pilgrimage

Editorial and overview of 2nd International Asia Pacific Religious Tourism and Pilgrimage Conference (APIRTP) was held in Universitas Islam Malang in Malang, Indonesia on 17 – 20 January 2024.


The Modern Pilgrimage Of Umrah: The Convergence Of Spiritual Devotion And Pop-Consumer Culture In Indonesia, Syamsu Madyan, Habil Abyad, Imam Wahyudi Karimullah Jun 2025

The Modern Pilgrimage Of Umrah: The Convergence Of Spiritual Devotion And Pop-Consumer Culture In Indonesia, Syamsu Madyan, Habil Abyad, Imam Wahyudi Karimullah

International Journal of Religious Tourism and Pilgrimage

This study explores Umrah’s significant growth as a religious tourism model in Indonesian Muslim society. The discussion examines factors that influence that growth, from the increased income levels of Indonesian middle-class Muslims to the Umrah propaganda generated by the wave of social media. This study will also capture Umrah as a solution for Indonesian Muslims to the long waiting queue for Hajj quota in Indonesia, as it is seen as a good opportunity for religious commodification through the touristic market being exercised by stakeholders such as policymakers and travel agencies. As the Umrah tourist market will be analysed in this …


Marketing Management Of Cemetery-Based Religious Sites To Improve The Economic Level Of Society, Dian Mohammad Hakim, Imam Wahyudi Karimullah, Winarto Winarto, Maskuri Maskuri Jun 2025

Marketing Management Of Cemetery-Based Religious Sites To Improve The Economic Level Of Society, Dian Mohammad Hakim, Imam Wahyudi Karimullah, Winarto Winarto, Maskuri Maskuri

International Journal of Religious Tourism and Pilgrimage

This study discussed the potential of cemetery-based religious tourism as an economic development strategy, with the Sunan Ampel Cemetery in Surabaya, Indonesia, as a case in point. By analysing its marketing management strategies, the study demonstrates that successful tourism development requires more than just pulling in tourists; it requires an integrated approach that includes infrastructure and technology development, stakeholder collaboration, and local community involvement. With close to two million visitors each year, Sunan Ampel is an excellent example of the huge economic gains from successful religious tourism efforts. This paper emphasises the need to convert historical religious sites from passive …


Religious Tolerance Through Prayer: Legal Analysis And Inter-Religious Prayer Interactions Communities In Realising Religious Harmony, Zuli Dwi Rahmawati, Siti Sumadiyah Jun 2025

Religious Tolerance Through Prayer: Legal Analysis And Inter-Religious Prayer Interactions Communities In Realising Religious Harmony, Zuli Dwi Rahmawati, Siti Sumadiyah

International Journal of Religious Tourism and Pilgrimage

Joint prayer is an activity that is performed by different religious groups at the same time and place. This practice can be done in the form of one or several people praying while others agree, or everyone prays together according to their respective religions. In Indonesia, the practice of joint prayer shows a discourse on religious tolerance in the diversity of society. The practice of prayer between religious people often triggers discussions on pros and cons among Indonesian people. In this article the law and the interaction of prayer between religious communities as an effort to understand the key role …


Untapped Halal-Friendly Tourism Potential For Taiwan, Arina Khoirunnisa, Indrawati Indrawati, Yu-Fang Yen, Subhash Kizhakanveatil Bhaskaran Pillai Jun 2025

Untapped Halal-Friendly Tourism Potential For Taiwan, Arina Khoirunnisa, Indrawati Indrawati, Yu-Fang Yen, Subhash Kizhakanveatil Bhaskaran Pillai

International Journal of Religious Tourism and Pilgrimage

Being the second largest belief, and fastest growing economy, many of the people from Muslim countries started travelling outside their countries due to increased economic prosperity and curiosity of exploring different cultures. The present study focuses on a non-Muslim country Taiwan, where the government is taking initiatives to attract the new segment of Muslim travellers. To support such initiatives, Halal-friendly-tourism is promoted in Taiwan. The pandemic period of 2019-2022 led to exploring different forms of tourism for reviving the ailing tourism sector, and cultural and heritage tourism is gaining prominence in this direction. Taiwan is trying to showcase its cultural …


Nostalgia, Trauma And Recovery: A Case Study Of Hazrat Hamza Shah Shrine, Ismail Rafik Shaikh, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati, Irfan Syed Mirza, Yu-Fang Yen, Arina Khoirunnisa Jun 2025

Nostalgia, Trauma And Recovery: A Case Study Of Hazrat Hamza Shah Shrine, Ismail Rafik Shaikh, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati, Irfan Syed Mirza, Yu-Fang Yen, Arina Khoirunnisa

International Journal of Religious Tourism and Pilgrimage

Religious tourism, as a pillar of spirituality and faith, continues to uplift and encourage believers in times of hardship. However, religious tourism was severely disrupted by the COVID-19 pandemic, which affected many stakeholders at different levels. This study explores the experiences of various stakeholders at the Hazrat Hamza Shah Shrine in Goa over three different time periods: nostalgia (before the pandemic), trauma (during the pandemic), and recovery (following the pandemic). Utilising qualitative data from interviews and social media sentiment analysis (53 posts on Facebook, 185 on Instagram, 64 on YouTube, and 102 on Google Maps), the study has identified a …


Optimized Wireless Power Transmission For Low-Cost, Energy-Efficient Internet Of Things Devices In Residential Environments, Daniel Brook Hatch Jun 2025

Optimized Wireless Power Transmission For Low-Cost, Energy-Efficient Internet Of Things Devices In Residential Environments, Daniel Brook Hatch

Theses and Dissertations

Wireless power transmission (WPT) offers a promising solution for powering devices in locations where traditional electrical outlets are inaccessible, such as ceilings or outdoor environments. By utilizing electromagnetic waves, such as light, WPT enables power delivery without the need for physical connections. With line-of-sight (LoS) as its primary limitation, this technology offers significant flexibility and potential for a wide range of applications, making it a compelling focus for research and innovation. Despite the advancements in WPT technologies, their practical application for powering Internet of Things (IoT) devices in real-world scenarios remains underexplored. Many IoT devices are installed in locations where …


Longitudinal Relations Between Self-Esteem And Depression: A Continuous Time Analysis With Exploration Of Sleep Duration Effects, Mackenzie Cummings Jun 2025

Longitudinal Relations Between Self-Esteem And Depression: A Continuous Time Analysis With Exploration Of Sleep Duration Effects, Mackenzie Cummings

Clinical Psychology Dissertations

Adolescents and young adults face elevated risk for depression. While poor self-esteem and sleep disturbance are known risk factors, few studies have examined their unique and interactive contributions. Longitudinal research often overlooks unequal intervals and multiple sources of variance (e.g., between- and within-person). This study used continuous time structural equation modeling to address these gaps and examine relationships between self-esteem, sleep duration, and depression from adolescence into adulthood. Drawing on four waves of data from the National Longitudinal Study of Adolescent to Adult Health (N = 6,184), I tested whether sleep duration moderated the self-esteem–depression link and explored gender differences. …


Toward Sustainable Human Well-Being: A Multidimensional Assessment In Colorado, Uma Umut Baysal Jun 2025

Toward Sustainable Human Well-Being: A Multidimensional Assessment In Colorado, Uma Umut Baysal

Electronic Theses and Dissertations

Evaluating progress in human well-being is essential for guiding effective policy and promoting sustainable development. Traditional approaches often emphasize economic and social dimensions while overlooking ecological indicators critical to long-term sustainability. This research addresses that gap by proposing a layered, scalable local framework for county-level analysis and bottom-up decision-making, integrating multiple objective indicators to assess and compare well-being outcomes across regions.

The first goal of this dissertation is to measure human well-being in Colorado counties by developing a Human Well-Being Index (HWBI). This index combines a newly developed Built Environment Index (BEI) comprising five sub-indices: accessibility, housing affordability, transportation, …


Paving The Way: Cultural Relevance In College And Career Readiness Programs, Jacqueline Turner Jun 2025

Paving The Way: Cultural Relevance In College And Career Readiness Programs, Jacqueline Turner

Electronic Theses and Dissertations

Students of color face persistent educational and systemic barriers that impact their success in college and career readiness (CCR) programs. Standardized approaches to CCR often fail to address the cultural identities, lived experiences, and needs of diverse learners (Castro, 2013; Malin et al., 2017; Welton & Martinez, 2014). Guided by the theoretical framework of Culturally Relevant Pedagogy, with the extension of Culturally Sustaining Pedagogy, this instrumental case study investigates how one CCR initiative—the Legacy Scholars Program (LSP), implemented by a Western Urban School District—integrates culturally responsive practices to better serve students of color. Through interviews, observations, and artifact analysis, this …


Staff Education Program On Care Transitions For The Elderly, Emmanoela Mugha Jun 2025

Staff Education Program On Care Transitions For The Elderly, Emmanoela Mugha

Walden Dissertations and Doctoral Studies

This project was developed as a staff education program using the analyze, design, develop, implement, and evaluate (ADDIE) model with a focus on discharge planning in a medical clinic in northern Maryland. There is a gap in discharge planning for older adults due to shortage of providers and inadequate education related to care transitions among the elderly. The care transition process can be improved through education. The practice focused question was: “Does an educational project for nurses on care transitions for the elderly increase knowledge as compared pre-to post education?” The Johns Hopkins evidence-based practice model (Appendix A) was the …


Reducing Hospital Readmissions For Medicare Patients With Chf And Copd, Darrell Shatel Mccrimon Jun 2025

Reducing Hospital Readmissions For Medicare Patients With Chf And Copd, Darrell Shatel Mccrimon

Walden Dissertations and Doctoral Studies

Hospital readmissions for Medicare beneficiaries with congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) contribute to increased healthcare costs and adverse outcomes. Evidence-based interventions, such as discharge planning, multidisciplinary care coordination, and patient education, have been implemented to reduce ambulatory care-sensitive admissions (ACSA), yet challenges in care continuity persist. This integrative review examined strategies adopted by healthcare organizations to reduce ACSA among Medicare beneficiaries with CHF and COPD. Guided by the utilization management framework, the review analyzed 19 studies and identified six primary themes: (a) integrated care models, (b) discharge and transitional care, (c) patient-centered interventions, (d) economic …


Employee Engagement And Productivity Among Remote Workers In The Finance Industry, Mauriom Ndikeh Jun 2025

Employee Engagement And Productivity Among Remote Workers In The Finance Industry, Mauriom Ndikeh

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic and its related restrictions made remote work a defining feature of the modern workforce. Some finance industry leaders lack effective employee engagement strategies to increase productivity in remote work environments. The purpose of this qualitative pragmatic inquiry project was to identify and explore successful employee engagement strategies some finance industry leaders used to increase productivity in remote work environments. This project was grounded in Kahn’s employee engagement theory. The participants were six finance industry leaders from financial organizations in the Northeast and Mid-Atlantic regions of the United States. Data were collected using semistructured Zoom interviews, field notes, …


The Impact Of Temperature Induced Vertebral Anomalies On C-Start Swimming Performance In Astyanax Mexicanus (Teleostei: Characidae), Kaleigh Arnold Jun 2025

The Impact Of Temperature Induced Vertebral Anomalies On C-Start Swimming Performance In Astyanax Mexicanus (Teleostei: Characidae), Kaleigh Arnold

College of Science and Health Theses and Dissertations

This study investigates the impact that temperature-induced vertebral anomalies have on the C-start escape response of Astyanax mexicanus, a model species in evolutionary developmental biology. Employing three temperature treatments to induce varying degrees of skeletal anomalies, we assessed their effects on key swimming performance metrics including, C-start time, the curvature coefficient, head displacement distance, and displacement velocity. Through the use of linear mixed models (LMMs) and generalized linear mixed models (GLMMs), our results reveal that specific anomalies such as vertebral fusions and anomalous haemal and neural spines affected the curving ability of c-start escape responses, however, these did not negatively …


Zeeman Effect Observations Of Water Masers In The Star Forming Region Ngc 7129 Firs2, Marina Bethann Beltran Jun 2025

Zeeman Effect Observations Of Water Masers In The Star Forming Region Ngc 7129 Firs2, Marina Bethann Beltran

College of Science and Health Theses and Dissertations

Magnetic fields likely play an important role in star formation, yet their influence remains poorly understood due to the observational challenges in measuring them. The only direct method for measuring magnetic fields is through the Zeeman effect, the splitting of spectral lines in the presence of a magnetic field. Water masers, which trace high-density shocked regions, are known to occur throughout some of the earliest stages of the star formation process. They provide an excellent opportunity to observe the Zeeman effect. However, Zeeman detections in H2O masers have so far been limited primarily to isolated, high-intensity maser lines with simple …


1 Herpes Simplex Virus Type 1 And Apolipoprotein-E In Alzheimer’S Disease: Virus Entry And Innate Immunity, Jim Camilleri Jun 2025

1 Herpes Simplex Virus Type 1 And Apolipoprotein-E In Alzheimer’S Disease: Virus Entry And Innate Immunity, Jim Camilleri

College of Science and Health Theses and Dissertations

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that has been detected in brains affected by Alzheimer’s Disease (AD), the leading global cause of cognitive decline. In vitro and epidemiological studies support a role for HSV-1 in AD. The strongest genetic risk factor for late-onset AD is the E4 allele of APOE, which codes for apolipoprotein-E (ApoE), a protein that mediates brain cholesterol homeostasis. Previous work has suggested that ApoE can affect HSV-1 entry into cells; however, APOE has three alleles (E2, E3, and E4) and allelespecific effects of ApoE on HSV-1 entry remain undetermined. We hypothesized that …


A Multilevel Analysis Of Arrest For Sexual Assault In The United States: The Effect Of Incident, Police Department, And Community Factors, Erin Elizabeth Hoffman Jun 2025

A Multilevel Analysis Of Arrest For Sexual Assault In The United States: The Effect Of Incident, Police Department, And Community Factors, Erin Elizabeth Hoffman

College of Science and Health Theses and Dissertations

Police officers play an important role for sexual assault survivors seeking help from the criminal legal system in the United States. One of their main responsibilities is to investigate the crime to determine if there is enough evidence to arrest a suspect. Previous literature has documented police arrest decisions in sexual assault cases are influenced by legal and extralegal factors—factors that are legally relevant (e.g., presence of DNA evidence) and irrelevant (e.g., victim race) in a case. These factors span multiple levels of analysis, namely the incident (e.g., whether a weapon was used) and police department (e.g., % of woman …


Gi, Pain, Anxiety, And Mood Symptoms Among Youth With Fapds, Helen Bedree Jun 2025

Gi, Pain, Anxiety, And Mood Symptoms Among Youth With Fapds, Helen Bedree

College of Science and Health Theses and Dissertations

Pediatric functional abdominal pain disorders (FAPDs) frequently persist into adulthood, thus developmental considerations are critical for monitoring symptom presentation and tailoring treatments. In addition to core symptoms, such as pain and gastrointestinal symptoms, mood and anxiety symptoms often co-occur as well as negative impacts on functioning and quality of life. The current study took a developmental approach to assess core pain, gastrointestinal, anxiety, and mood symptoms among youth with FAPDs (N = 105), as well as agreement across youth and their caregivers on these key symptoms. Developmental stages included early childhood, middle childhood, adolescence, and emerging adulthood. A cluster …


The Impact And Perceptions Of Return-To-Office Mandates, Brooke E. Nyberg Jun 2025

The Impact And Perceptions Of Return-To-Office Mandates, Brooke E. Nyberg

College of Science and Health Theses and Dissertations

In the aftermath of stay-at-home mandates that resulted from the COVID-19 pandemic, many organizations have reinstated mandates requiring that employees return to the office either full-time or a few days per week. Although research has been conducted on the benefits and consequences of remote work throughout the pandemic, research is lacking on the perceptions of the return-to-office mandates and how these mandates impact employees. This study aimed to comprehensively understand what employees think and feel about a return-to-office mandate as well as identify group differences and impacts of the method in which the RTO mandate was communicated. To do so, …


Examining Changes In Control Beliefs And The Role Of Self-Determination In A Cognitive-Behavioral Intervention For Elementary-Aged Students, Laura Saldana Jun 2025

Examining Changes In Control Beliefs And The Role Of Self-Determination In A Cognitive-Behavioral Intervention For Elementary-Aged Students, Laura Saldana

College of Science and Health Theses and Dissertations

To date, cognitive behavioral intervention studies for youth focus on symptom reduction to evaluate treatment efficacy without studying changes in youth coping. The present study, backed by Motivational Theory of Coping and Self-Determination Theory, used a randomized control trial design to examine the effects of a brief (5-session), group-based, cognitive-behavioral intervention called Act and Adapt – SP on adaptive coping, maladaptive coping, competence, and relatedness in a sample of academically underperforming 3rd and 4th graders (N = 56; Mage = 8.8 years; 62.5% female; 78.6% Latinx). Act and Adapt – SP was designed for Saturday …


A Mixed Methods Survey To Highlight Retrospective Drug Spending, Dillon Peter Thorpe Jun 2025

A Mixed Methods Survey To Highlight Retrospective Drug Spending, Dillon Peter Thorpe

College of Science and Health Theses and Dissertations

The financial impact of substance use is poorly understood. What research has been conducted has focused on societal and medical costs, rarely on the personal finances of substance users. Less research has been conducted on the finances of people currently in recovery and abstinence. To fill in this gap, 284 current Oxford House residents completed a survey that inquired about demographics, spending habits, and reasons for staying in Oxford House. Following analysis, it was found that previous drug/alcohol spending is a highly variable metric, with a range of $0-$30,000 per month. In addition, the sample was homogenous in terms of …


The Effect Of Reading Goals On Conspiracy Believability And Memorability, Leah Patricia O'Neill Jun 2025

The Effect Of Reading Goals On Conspiracy Believability And Memorability, Leah Patricia O'Neill

College of Science and Health Theses and Dissertations

Previous research shows that individuals who are assigned different goals for reading remember and comprehend text differently, which might also influence how individuals read texts that contain conspiracy theories. This research has revealed a connection between scores on the Schizotypal Personality Questionnaire-Brief (SPQ-B) and conspiracy theory belief, such that those who score higher are more likely to believe in conspiracy theories. Therefore, this study investigated the influence of reading goals (i.e., study vs entertainment) and different types of conspiracy theories (i.e., familiar and less familiar) on participant’s believability ratings for conspiracy texts. Participants were assigned a reading goal prior to …


The Impact Of Popularity Pressure: A Moderated Mediation Model, Molly Clare Walker Jun 2025

The Impact Of Popularity Pressure: A Moderated Mediation Model, Molly Clare Walker

College of Science and Health Theses and Dissertations

Adolescence is a critical development stage where social pressures can significantly impact interactions and behavior. One such pressure, popularity pressure, refers to adolescents’ perceived obligation to meet social expectations related to having a popular status. Prior research by Wright (2020) highlights that perceived popularity pressure, often driven by parental and peer influence, is linked to maladaptive behaviors such as relational aggression. Despite these findings, limited research has yet to explore the effect of popularity pressure on adolescents’ internalizing symptoms such as anxiety and depression, in addition to the underlying mechanisms through which popularity pressure impacts adolescents’ mental health and behavior. …


Early Diagnosis And Detection Of Skin Cancer Using Deep Neural Network Models And Feature Extraction From Pre-Trained Cnns, Sahil Khanna Jun 2025

Early Diagnosis And Detection Of Skin Cancer Using Deep Neural Network Models And Feature Extraction From Pre-Trained Cnns, Sahil Khanna

Harrisburg University Dissertations and Theses

Skin cancer is one of the most common and lethal cancer types. While accurate diagnosis at an early stage is essential for skin cancer treatment it remains difficult to achieve in many regions due to lack of sufficient dermatologists and proper diagnostic equipment. Prior studies show Convolutional Neural Network (CNN) models excel at skin lesion classification and consistently achieve better results than standard diagnostic practices. However, the focus of many studies remains confined to image-based learning while neglecting useful patient metadata that could improve prediction accuracy. This research project created a specialized CNN model to classify skin lesions and evaluated …


Investigating Momentary Body Image Disturbance, Affect, And Disordered Eating Among College Students, Allison T. Cunning Jun 2025

Investigating Momentary Body Image Disturbance, Affect, And Disordered Eating Among College Students, Allison T. Cunning

USF Tampa Graduate Theses and Dissertations

Despite evidence that eating disorders are associated with elevated mortality rates, increased risk of suicide, and societal and financial burden, treatment outcomes for individuals with eating disorders remain poor. Body image disturbance has emerged as a robust risk factor for the development and maintenance of disordered eating (e.g., overeating, binge eating, purging, restriction) and theoretical and clinical perspectives most commonly operationalize body image disturbance as a trait construct. However, empirical evidence suggests body dissatisfaction may fluctuate, and these fluctuations may play an important role in the relationship between risk factors and disordered eating. The current study employed ecological momentary assessment …


Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve Jun 2025

Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve

Plants, Soils and Climate Student Research

Water scarcity is a critical challenge in arid and semi-arid regions, where agricultural water consumption accounts for a significant portion of freshwater use. Conventional agriculture (CA) methods with high reliance on chemical and mechanical inputs often exacerbate this issue through soil degradation and water loss. This review aims to examine how different organic practices, such as mulching, cover cropping, composting, crop rotation, and no-till (NT) in combination with precision technologies, can contribute to water optimization, and it discusses the opportunities and challenges for the adoption and implementation of those practices. Previous findings show that organic agriculture (OA) may outperform CA …


In Living Memory: Curatorial Perspectives Of Jewish Heritage In Holocaust Public Histories, Hannah M. Lahti Jun 2025

In Living Memory: Curatorial Perspectives Of Jewish Heritage In Holocaust Public Histories, Hannah M. Lahti

Dissertations

Holocaust Museums present a history of the genocide of European Jews, while Jewish Museums represent the long history and diverse cultures of Jewish life. By examining Holocaust public histories in Poland and the United States, this dissertation outlines the historical and memorial conditions that inform museum exhibits, as well as the curatorial approaches that synthesize historical information, spatial contexts, and material culture into exhibition narratives and historical representation. This dissertation employs exhibition analysis to explain existing curatorial approaches in Holocaust public histories and identifies curatorial principles and methods of display that might translate to new exhibits. Informed by the models …


Regulation Of Spermatogenesis By The Notch Signaling Pathway, Emma O'Flaherty Jun 2025

Regulation Of Spermatogenesis By The Notch Signaling Pathway, Emma O'Flaherty

Master's Theses

The Notch signaling pathway plays a significant role in gonad development and spermatogenesis, but little is known about its specific targets in the testis. The Drosophila testis contains two populations of stem cells: germline stem cells and cyst stem cells, which give rise to differentiating germline and somatic cyst cells, respectively. Notch signaling is activated in the somatic cyst cells by the Delta ligand from the germline in a region of the testes coined the “transition zone”, where somatic cyst cells progress from early cyst cells surrounding gonialblasts and 2-cell germline cysts to late cyst cells surrounding 16-cell spermatocyte cysts. …


Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann Jun 2025

Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann

Faculty, Staff and Student Publications

Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papillary mucinous neoplasms (IPMN), recognized pancreatic cancer precursors, to identify oncometabolites that inform upon risk of malignancy of IPMNs.

Experimental design: Untargeted metabolomic analyses were performed on cystic fluid from 125 patients with low-grade (LG) dysplasia or high-grade (HG) dysplasia with/without concurrent pancreatic ductal adenocarcinoma (PDAC; IPMN/PDAC). Predictive performance of individual metabolites for identifying HG or PDAC/IPMN was determined and compared with CA19-9 performance. Data were intersected with metabolic profiles of resected IPMN tissues and murine Kras;Gnas IPMN cell lines as well as spatial and single-cell transcriptomics of IPMNs.

Results: …


Azacitidine, Venetoclax, And Magrolimab In Newly Diagnosed And Relapsed Refractory Acute Myeloid Leukemia: Phase Ib/Ii Study And Correlative Analysis, Naval Daver, Jayastu Senapati, Hagop M Kantarjian, Bofei Wang, Patrick K Reville, Sanam Loghavi, Musa Yilmaz, Courtney D Dinardo, Tapan M Kadia, Mhd Yousuf Yassouf, Abhishek Maiti, Sankalp Arora, Guillermo Montalban Bravo, Guilin Tang, Gautam Borthakur, Koji Sasaki, Naveen Pemmaraju, Joie Alvarez, Graciela M Nogueras Gonzalez, Jing Ning, Ghayas C Issa, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Guillermo Garcia-Manero, Hussein A Abbas Jun 2025

Azacitidine, Venetoclax, And Magrolimab In Newly Diagnosed And Relapsed Refractory Acute Myeloid Leukemia: Phase Ib/Ii Study And Correlative Analysis, Naval Daver, Jayastu Senapati, Hagop M Kantarjian, Bofei Wang, Patrick K Reville, Sanam Loghavi, Musa Yilmaz, Courtney D Dinardo, Tapan M Kadia, Mhd Yousuf Yassouf, Abhishek Maiti, Sankalp Arora, Guillermo Montalban Bravo, Guilin Tang, Gautam Borthakur, Koji Sasaki, Naveen Pemmaraju, Joie Alvarez, Graciela M Nogueras Gonzalez, Jing Ning, Ghayas C Issa, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Guillermo Garcia-Manero, Hussein A Abbas

Faculty, Staff and Student Publications

Purpose: Magrolimab is a monoclonal antibody directed against the macrophage checkpoint CD47 on myeloid leukemia cells that was preclinically synergistic with azacitidine-venetoclax, warranting further clinical evaluation.

Patients and methods: In this phase Ib/II study, the triplet combination of azacitidine, venetoclax, and magrolimab was evaluated in adult patients with first-line (ineligible for intensive chemotherapy) and relapsed/refractory acute myeloid leukemia. Azacitidine was dosed at 75 mg/m2 for 7 days, venetoclax at 400 mg/day for 28 days, and magrolimab (recommended phase II dose) as follows: 1 mg/kg dose on days 1 and 4, 15 mg/kg on day 8, and 30 mg/kg on days …