Digital Commons Network^™

Through The Ai-Looking Glass And What Consumers Find There, Ashley Krenelka Chase, Sam Harden

Journal of Technology Law & Policy

While a lack of internet regulation is the norm in the United States, generative artificial intelligence (AI) presents a series of new challenges, particularly in the legal field. Those who are trained in the law know to check their sources, whether they come from case law or a generative AI tool like ChatGPT, but the average consumer is not so discerning. When that average consumer is in the midst of dealing with legal issues and has to navigate those issues without a lawyer, he or she is less likely to sit back and evaluate the information they’re being given, particularly …

Yiqi Yangyin Tongluo Prescription Targets Lncrna Vim-As1 To Regulate Foxk2/Mtor To Promote Autophagy And Inhibit Renal Tubular Epithelial Cell Apoptosis, Rucui Yu, Ruiying Wu, Tingting Chen, Jingwei Xu

Journal of Food and Drug Analysis

Diabetic nephropathy (DN) is one dominating reason for death in diabetic patients, and its incidence is high. It has been reported that Yiqi Yangyin Tongluo prescription (YYTP) can relieve inflammation, and it owns better clinical effects in the treatment of DN. However, the molecular mechanisms of YYTP in the treatment of DN still keep unclear, and deeply investigations are needed. In this study, it firstly was manifested that YYTP can repress the lncRNA VIM-antisense 1 (VIM-AS1) expression in high glucose (HG)-evoked HK-2 cells. Overexpression of VIM-AS1 roll-backed the inhibitive impacts of YYTP on cell apoptosis in HG-triggered HK-2 cells. Additionally, …

Evaluating The Cost-Effectiveness Of Atezolizumab-Bevacizumab In Advanced Hepatocellular Carcinoma: Insights From Taiwan, Tsung-Wei Chang, Wei-Chiao Chang, Wan-Hsuan Chou, Wei-Pin Chang, Chun-Nan Kuo

Journal of Food and Drug Analysis

Following the observed significant improvements in overall survival and progression-free survival in clinical trials, the combination of atezolizumab and bevacizumab has been recommended as a first-line therapy for patients with unresectable hepatocellular carcinoma. Despite its clinical benefits, the high cost associated with this treatment poses a substantial challenge in routine practice in Taiwan. This study aims to assess the cost-effectiveness of atezolizumab plus bevacizumab in comparison to sorafenib monotherapy. This study utilized partitioned survival analysis and extrapolated survival over a 20-year horizon to conduct a cost-effectiveness analysis from the perspective of the National Health Insurance Administration. Efficacy and utility data …

Ping-Chong-Jiang-Ni Formula Effectively Inhibits Migration And Invasion Of Endometriosis 12z Cell Line Via Trip13, Jiahua Peng, Shuzhen Liu, Yunxiang Xie, Min Xiao, Chichiu Wang, Ruining Liang

Journal of Food and Drug Analysis

The Ping-Chong-Jiang-Ni Formula (PCJNF), a compound of Traditional Chinese Medicine (TCM), has demonstrated remarkable clinical effectiveness and is widely utilized in the treatment of endometriosis (EMs). Previous studies have shown that PCJNF inhibits the proliferation and induces the apoptosis of ectopic endometrial stromal cells (EESCs) by modulating the JNK signaling pathway. In our most recent study, published in January 2024, we found that PCJNF effectively alleviates EMs-associated pain by reducing inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and nerve growth factor (NGF). Furthermore, PCJNF down-

regulates the expression of transient receptor potential vanilloid 1 (TRPV1), phosphorylated TRPV1 (p-TRPV1), and protein …

In Vitro Metabolic Profiling Of Methylenedioxy-Substituted Synthetic Cathinones For Enhanced Detection In Urine Sample Analysis, Ya-Ling Yeh, Chin-Lin Hsieh, Yi-Jia Huang, Yu-Hsiang Chang, Sheng-Meng Wang

Journal of Food and Drug Analysis

Synthetic cathinones are a widely abused class of new psychoactive substances that pose significant challenges in forensic toxicology owing to their complex metabolic pathways and lack of verified reference standards. This study investigated the in vitro metabolism of nine methylenedioxy-substituted synthetic cathinones, including methylone and eight structural isomers, which were categorized into three groups: Group 1 (dimethylone, ethylone, and butylone), Group 2 (dibutylone, pentylone, and eutylone), and Group 3 (N-ethylpentylone and dipentylone). Pooled human liver microsomes, cytosol, and uridine diphosphate glucuronic acid were used to identify phase Ⅰ and Ⅱ metabolites by liquid chromatography–quadrupole time-of-flight mass spectrometry. Key pathways included …

Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis, Quan Liao, Zhenzhen Guo, Chenchun Ding, Renjie Zuo, Guoyan Liu

Journal of Food and Drug Analysis

Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experiments demonstrated the efficacy of VA in alleviating CAG, and network pharmacology analysis revealed its involvement in related terms, including inflammation, oxidative stress, and cell proliferation. Analyses further confirmed the modulation of ferroptosis by VA, particularly via the Keap1-Nrf2/HO-1/GPX4 pathway. In vitro assays supported these findings, demonstrating the ability of VA to reduce methylnitronitrosoguanidine-induced inflammation, oxidative stress, and ferroptosis in GES-1. This study provides a basis for …

Jiao San Xian Granule Containing Prebiotic Alleviate Functional Dyspepsia By Regulating Intestinal Flora And The Secretion Of Inflammatory Response, Huimin Pei, Mengyuan Zhao, Hongyue Wang, Xindi Zhang, Caihong Shi, Xiangrong Zhang

Journal of Food and Drug Analysis

Jiao Sanxian (JSX) consists of three traditional Chinese medicine including charred hawthorn, malt and Liu Shen Qu, they are also from Chinese medicine homologous food. It is commonly used to relieve functional dyspepsia (FD). The present study aims to explore the mechanism of JSX (granule), with the addition of prebiotics for the treatment of FD using mice model. The network pharmacology and molecular docking were used to forecast therapeutic targets for JSX. Based on the protein-protein interaction (PPI) results, thirteen targets exhibited strong interactions with each other. The results of network pharmacology and molecular docking revealed therapeutic activity of JSX …

Regulatory Framework And Challenges For Live Biotherapeutic Products In Taiwan, Shirley Pan, Jia-Chuan Hsu, Kuo-Teng Hung, Ching-Jung Ho

Journal of Food and Drug Analysis

Products containing live microorganisms may be classified as food or drugs depending on their intended use; live biotherapeutic products (LBPs) with therapeutic claims are defined as medicinal products containing live bacteria or yeasts intended to prevent or treat disease. Based on their characteristics, LBPs are classified as biological drugs and must be registered as biological drugs before they can enter the Taiwanese market. As research into the microbiota and its role in health and disease continues to advance, LBPs are expected to play an increasingly important role in medicine and biotechnology. With the growing popularity of microbial applications in recent …

Aspergillosis: A Comprehensive Review Of Pathogenesis, Drug Resistance, And Emerging Therapeutics, Amanpreet Singh, Jeewanjot Singh, Sandeep Kumar

Journal of Food and Drug Analysis

Aspergillosis stands as a primary opportunistic fungal infection which mainly results from Aspergillus fumigatus events that have gained more importance because of its multiple infection patterns and developing antifungal resistance. Healthcare providers identify two main ends of the aspergillosis spectrum which include allergic responses and invasive systemic infections that affect mainly immunocompromised subjects. This review presents a detailed summary for understanding the epidemiology of aspergillosis along with its risk factors as well as pathogenesis and host immune response and diagnostic difficulties. The analysis puts significant weight on increasing azole and echinocandin resistance that has become worse because of agricultural and …

Folder 70, Sapp Award, 1951, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 71, Sapp Award, 1952, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 72, Sapp Award, 1953, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 73, Sapp Award, 1954, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 74, Sapp Award, 1955, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 75, Sapp Award, 1956, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 76, Sapp Award, 1957, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 77, Sapp Award, 1958, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 78, Sapp Award, 1959, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 79, Schedule Of Classes, 1951, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 80, Senate Clerkships, 1947-1948, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 81, South Carolina Bar Association History, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 82, South Carolina Law Quarterly, 1951, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 83, South Carolina Law Quarterly, 1953-1954, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 84, South Carolina Law Quarterly, 1955, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 85, South Carolina Law Quarterly, 1956, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 86, South Carolina Law Quarterly, 1957, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 87, South Carolina Law Quarterly, 1958, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Folder 88, South Carolina Law Quarterly, 1959, Samuel Lander Prince

Prince, Samuel Lander (1946-1959)

No abstract provided.

Psychometric Evaluation Of The Thai Version Of Emotional Labor Scale (T-Els) In Thai Nurses, Vachira Posai, Wisarut Srisintorn, Paramee Thongsuksai, Chanokporn Jitpanya

Journal of Health Research

Background: Nurses often face emotional strain due to emotional labor (EL), which involves concealing or modifying genuine feelings to meet their job requirements. This response can lead to physical, psychological, and behavioral issues. The Emotional Labor Scale (ELS), originally in English, has not been translated into Thai, leaving its psychometric properties unexamined in the Thai context. This study aimed to translate the ELS into Thai and evaluate its psychometric properties among Thai nurses.

Methods: A cross-sectional study design was used. The 14-item scale, which includes surface acting, deep acting, and expression of naturally felt emotions dimensions, was translated using forward …

Predictive Model For Hemoglobin Levels Using Multiple Linear Regression, Dien Gusta Anggraini Nursal, Muhammad Daffa Atthariq Winata, Nohan Arum Romadlona, Noura Rizki, Sabillah Nasitoh, Muhammad Sakhi Baretta

Journal of Health Research

Background: Anemia is a condition in which the number of red blood cells or hemoglobin (Hb) levels fall below normal, limiting the ability of blood to transport oxygen effectively. This study aimed to develop a predictive model for Hb levels by identifying significant risk factors.

Method: This observational analytic study was conducted among 103 randomly selected students of Bung Hatta University in Padang, Indonesia. Data were collected with a questionnaire and a hemoglobin test between April to May 2024. Pearson’s correlation analysis and multiple linear regression were performed in this study.

Results: Bivariate analysis showed significant correlations between Hb levels …