Digital Commons Network^™

1 Herpes Simplex Virus Type 1 And Apolipoprotein-E In Alzheimer’S Disease: Virus Entry And Innate Immunity, Jim Camilleri

College of Science and Health Theses and Dissertations

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that has been detected in brains affected by Alzheimer’s Disease (AD), the leading global cause of cognitive decline. In vitro and epidemiological studies support a role for HSV-1 in AD. The strongest genetic risk factor for late-onset AD is the E4 allele of APOE, which codes for apolipoprotein-E (ApoE), a protein that mediates brain cholesterol homeostasis. Previous work has suggested that ApoE can affect HSV-1 entry into cells; however, APOE has three alleles (E2, E3, and E4) and allelespecific effects of ApoE on HSV-1 entry remain undetermined. We hypothesized that …

A Multilevel Analysis Of Arrest For Sexual Assault In The United States: The Effect Of Incident, Police Department, And Community Factors, Erin Elizabeth Hoffman

College of Science and Health Theses and Dissertations

Police officers play an important role for sexual assault survivors seeking help from the criminal legal system in the United States. One of their main responsibilities is to investigate the crime to determine if there is enough evidence to arrest a suspect. Previous literature has documented police arrest decisions in sexual assault cases are influenced by legal and extralegal factors—factors that are legally relevant (e.g., presence of DNA evidence) and irrelevant (e.g., victim race) in a case. These factors span multiple levels of analysis, namely the incident (e.g., whether a weapon was used) and police department (e.g., % of woman …

Gi, Pain, Anxiety, And Mood Symptoms Among Youth With Fapds, Helen Bedree

College of Science and Health Theses and Dissertations

Pediatric functional abdominal pain disorders (FAPDs) frequently persist into adulthood, thus developmental considerations are critical for monitoring symptom presentation and tailoring treatments. In addition to core symptoms, such as pain and gastrointestinal symptoms, mood and anxiety symptoms often co-occur as well as negative impacts on functioning and quality of life. The current study took a developmental approach to assess core pain, gastrointestinal, anxiety, and mood symptoms among youth with FAPDs (N = 105), as well as agreement across youth and their caregivers on these key symptoms. Developmental stages included early childhood, middle childhood, adolescence, and emerging adulthood. A cluster …

The Impact And Perceptions Of Return-To-Office Mandates, Brooke E. Nyberg

College of Science and Health Theses and Dissertations

In the aftermath of stay-at-home mandates that resulted from the COVID-19 pandemic, many organizations have reinstated mandates requiring that employees return to the office either full-time or a few days per week. Although research has been conducted on the benefits and consequences of remote work throughout the pandemic, research is lacking on the perceptions of the return-to-office mandates and how these mandates impact employees. This study aimed to comprehensively understand what employees think and feel about a return-to-office mandate as well as identify group differences and impacts of the method in which the RTO mandate was communicated. To do so, …

Examining Changes In Control Beliefs And The Role Of Self-Determination In A Cognitive-Behavioral Intervention For Elementary-Aged Students, Laura Saldana

College of Science and Health Theses and Dissertations

To date, cognitive behavioral intervention studies for youth focus on symptom reduction to evaluate treatment efficacy without studying changes in youth coping. The present study, backed by Motivational Theory of Coping and Self-Determination Theory, used a randomized control trial design to examine the effects of a brief (5-session), group-based, cognitive-behavioral intervention called Act and Adapt – SP on adaptive coping, maladaptive coping, competence, and relatedness in a sample of academically underperforming 3^rd and 4^th graders (N = 56; M_age = 8.8 years; 62.5% female; 78.6% Latinx). Act and Adapt – SP was designed for Saturday …

A Mixed Methods Survey To Highlight Retrospective Drug Spending, Dillon Peter Thorpe

College of Science and Health Theses and Dissertations

The financial impact of substance use is poorly understood. What research has been conducted has focused on societal and medical costs, rarely on the personal finances of substance users. Less research has been conducted on the finances of people currently in recovery and abstinence. To fill in this gap, 284 current Oxford House residents completed a survey that inquired about demographics, spending habits, and reasons for staying in Oxford House. Following analysis, it was found that previous drug/alcohol spending is a highly variable metric, with a range of $0-$30,000 per month. In addition, the sample was homogenous in terms of …

The Effect Of Reading Goals On Conspiracy Believability And Memorability, Leah Patricia O'Neill

College of Science and Health Theses and Dissertations

Previous research shows that individuals who are assigned different goals for reading remember and comprehend text differently, which might also influence how individuals read texts that contain conspiracy theories. This research has revealed a connection between scores on the Schizotypal Personality Questionnaire-Brief (SPQ-B) and conspiracy theory belief, such that those who score higher are more likely to believe in conspiracy theories. Therefore, this study investigated the influence of reading goals (i.e., study vs entertainment) and different types of conspiracy theories (i.e., familiar and less familiar) on participant’s believability ratings for conspiracy texts. Participants were assigned a reading goal prior to …

The Impact Of Popularity Pressure: A Moderated Mediation Model, Molly Clare Walker

College of Science and Health Theses and Dissertations

Adolescence is a critical development stage where social pressures can significantly impact interactions and behavior. One such pressure, popularity pressure, refers to adolescents’ perceived obligation to meet social expectations related to having a popular status. Prior research by Wright (2020) highlights that perceived popularity pressure, often driven by parental and peer influence, is linked to maladaptive behaviors such as relational aggression. Despite these findings, limited research has yet to explore the effect of popularity pressure on adolescents’ internalizing symptoms such as anxiety and depression, in addition to the underlying mechanisms through which popularity pressure impacts adolescents’ mental health and behavior. …

Early Diagnosis And Detection Of Skin Cancer Using Deep Neural Network Models And Feature Extraction From Pre-Trained Cnns, Sahil Khanna

Harrisburg University Dissertations and Theses

Skin cancer is one of the most common and lethal cancer types. While accurate diagnosis at an early stage is essential for skin cancer treatment it remains difficult to achieve in many regions due to lack of sufficient dermatologists and proper diagnostic equipment. Prior studies show Convolutional Neural Network (CNN) models excel at skin lesion classification and consistently achieve better results than standard diagnostic practices. However, the focus of many studies remains confined to image-based learning while neglecting useful patient metadata that could improve prediction accuracy. This research project created a specialized CNN model to classify skin lesions and evaluated …

To Study The Correlation Between Project Management Methodologies, Leadership Styles, And Team Engagement., Mouna Ittira Subbaiah

Harrisburg University Dissertations and Theses

The software industry is expanding rapidly due to emerging technologies, innovative business strategies, and evolving customer demands. Software projects vary in complexity, requiring diverse approaches to ensure successful development from initiation to completion. This complexity has driven the adoption of continuous learning, lean principles, and agile methodologies. Modern methodologies prioritize flexibility, adaptability, productivity, inclusivity, and knowledge sharing. The choice of a particular method depends on organizational culture and project characteristics. The characteristics of the methodology will directly and indirectly influence team engagement. However, transitioning between methods can be challenging, involving significant costs and time investments. Recently, many organizations have shifted …

Is She Being “Fast?”: Exploration Of African American Women’S Experience With Sexual Objectification, Alaigra V.R. Usher

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Issues of sexual objectification have been intertwined in America’s history since enslavement. This phenomenology study aimed to explore African American women’s lived experiences with sexual objectification and to understand the essential themes and conceptualizations that African American women attribute to sexual objectification. Through semi-structured interviews with a criterion sampling of African American women, the research sought to identify core themes surrounding sexual objectification experiences. In the results of this study, it was found that this population conceptualizes their sexual objectification experiences through seven themes: Earliest Sexual Objectification Experiences (SOE), SOE, Responses to SOE, Parental Protection, Reasons for SOE, SOE places, …

Investigating Momentary Body Image Disturbance, Affect, And Disordered Eating Among College Students, Allison T. Cunning

USF Tampa Graduate Theses and Dissertations

Despite evidence that eating disorders are associated with elevated mortality rates, increased risk of suicide, and societal and financial burden, treatment outcomes for individuals with eating disorders remain poor. Body image disturbance has emerged as a robust risk factor for the development and maintenance of disordered eating (e.g., overeating, binge eating, purging, restriction) and theoretical and clinical perspectives most commonly operationalize body image disturbance as a trait construct. However, empirical evidence suggests body dissatisfaction may fluctuate, and these fluctuations may play an important role in the relationship between risk factors and disordered eating. The current study employed ecological momentary assessment …

Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve

Plants, Soils and Climate Student Research

Water scarcity is a critical challenge in arid and semi-arid regions, where agricultural water consumption accounts for a significant portion of freshwater use. Conventional agriculture (CA) methods with high reliance on chemical and mechanical inputs often exacerbate this issue through soil degradation and water loss. This review aims to examine how different organic practices, such as mulching, cover cropping, composting, crop rotation, and no-till (NT) in combination with precision technologies, can contribute to water optimization, and it discusses the opportunities and challenges for the adoption and implementation of those practices. Previous findings show that organic agriculture (OA) may outperform CA …

In Living Memory: Curatorial Perspectives Of Jewish Heritage In Holocaust Public Histories, Hannah M. Lahti

Dissertations

Holocaust Museums present a history of the genocide of European Jews, while Jewish Museums represent the long history and diverse cultures of Jewish life. By examining Holocaust public histories in Poland and the United States, this dissertation outlines the historical and memorial conditions that inform museum exhibits, as well as the curatorial approaches that synthesize historical information, spatial contexts, and material culture into exhibition narratives and historical representation. This dissertation employs exhibition analysis to explain existing curatorial approaches in Holocaust public histories and identifies curatorial principles and methods of display that might translate to new exhibits. Informed by the models …

Regulation Of Spermatogenesis By The Notch Signaling Pathway, Emma O'Flaherty

Master's Theses

The Notch signaling pathway plays a significant role in gonad development and spermatogenesis, but little is known about its specific targets in the testis. The Drosophila testis contains two populations of stem cells: germline stem cells and cyst stem cells, which give rise to differentiating germline and somatic cyst cells, respectively. Notch signaling is activated in the somatic cyst cells by the Delta ligand from the germline in a region of the testes coined the “transition zone”, where somatic cyst cells progress from early cyst cells surrounding gonialblasts and 2-cell germline cysts to late cyst cells surrounding 16-cell spermatocyte cysts. …

7606 17th Avenue Llc. V. Santiago

All Decisions

In a holdover proceeding, the court dismissed the petition due to a defective notice of petition. Judge Cohen found that the notice contained substantive errors, specifically the use of "the premises" instead of the mandated "your home," and the complete omission of the required explanatory sentence: "that means the landlord says you should be evicted for a reason other than not paying your rent." The court deemed these errors, particularly the omitted sentence, to be significant and not de minimis, as they could confuse a pro se litigant regarding the nature of the holdover. The petitioner's cross-motion to amend was …

Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann

Faculty, Staff and Student Publications

Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papillary mucinous neoplasms (IPMN), recognized pancreatic cancer precursors, to identify oncometabolites that inform upon risk of malignancy of IPMNs.

Experimental design: Untargeted metabolomic analyses were performed on cystic fluid from 125 patients with low-grade (LG) dysplasia or high-grade (HG) dysplasia with/without concurrent pancreatic ductal adenocarcinoma (PDAC; IPMN/PDAC). Predictive performance of individual metabolites for identifying HG or PDAC/IPMN was determined and compared with CA19-9 performance. Data were intersected with metabolic profiles of resected IPMN tissues and murine Kras;Gnas IPMN cell lines as well as spatial and single-cell transcriptomics of IPMNs.

Results: …

Azacitidine, Venetoclax, And Magrolimab In Newly Diagnosed And Relapsed Refractory Acute Myeloid Leukemia: Phase Ib/Ii Study And Correlative Analysis, Naval Daver, Jayastu Senapati, Hagop M Kantarjian, Bofei Wang, Patrick K Reville, Sanam Loghavi, Musa Yilmaz, Courtney D Dinardo, Tapan M Kadia, Mhd Yousuf Yassouf, Abhishek Maiti, Sankalp Arora, Guillermo Montalban Bravo, Guilin Tang, Gautam Borthakur, Koji Sasaki, Naveen Pemmaraju, Joie Alvarez, Graciela M Nogueras Gonzalez, Jing Ning, Ghayas C Issa, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Guillermo Garcia-Manero, Hussein A Abbas

Faculty, Staff and Student Publications

Purpose: Magrolimab is a monoclonal antibody directed against the macrophage checkpoint CD47 on myeloid leukemia cells that was preclinically synergistic with azacitidine-venetoclax, warranting further clinical evaluation.

Patients and methods: In this phase Ib/II study, the triplet combination of azacitidine, venetoclax, and magrolimab was evaluated in adult patients with first-line (ineligible for intensive chemotherapy) and relapsed/refractory acute myeloid leukemia. Azacitidine was dosed at 75 mg/m2 for 7 days, venetoclax at 400 mg/day for 28 days, and magrolimab (recommended phase II dose) as follows: 1 mg/kg dose on days 1 and 4, 15 mg/kg on day 8, and 30 mg/kg on days …

Time Dependency For Human Papillomavirus Circulating Tumor Dna Detection After Chemoradiation As A Prognostic Biomarker For Localized Anal Cancer, Van K Morris, Weihong Xiao, Kangyu Lin, Chi Wut Wong, Michael T Wotman, Emma B Holliday, Ryan W Huey, Sonal S Noticewala, Ethan B Ludmir, Alisha H Bent, Kaysia Ludford, Craig Messick, Eugene J Koay, Grace Smith, Tsuyoshi Konishi, Brian Bednarski, George J Chang, Albert C Koong, Y Nancy You, Prajnan Das, Maura L Gillison

Faculty, Staff and Student Publications

Purpose: Although detection of ctDNA weeks after surgery is linked to recurrence for other solid tumors, the optimal time point for ctDNA assessment as a prognostic biomarker following chemoradiation for anal cancer is undefined.

Experimental design: Patients with stages I to III anal cancer treated with chemoradiation between December 2020 and March 2024 were evaluated for human papillomavirus (HPV) ctDNA status at baseline, at the end of chemoradiation, and during surveillance using a droplet digital HPV ctDNA PCR assay, targeting HPV E6 and E7 oncogenes for 13 oncogenic HPV types. Median recurrence-free survival (RFS) according to HPV ctDNA status was …

Community Care: Raising The Profile Of The Library Through Programming, Deborah Beagle, Carrie Evans, Maxine Girard, Bridget Kennedy, Mike Mannheim

Librarian Publications

Starting in Spring 2024, librarians at Western New England University D’Amour Library began seeking ways to increase student engagement in response to a new focus on student wellness. Leveraging their own strengths and interests, they began hosting weekly Crochet, Crafting and First-Generation College Student drop-ins, which eventually grew into a total of five regular library programs. These programs have proven overwhelmingly popular, with scores of students attending per week. Additionally, the programs have raised the profile of the library across campus, enabled collaborations with other campus groups, and increased student connections. Staff morale has also been improved, as Librarians have …

Utility Of Carboxyhemoglobin Level For The Diagnosis Of Invasive Bacterial Infection In A Febrile Neonate At Paediatric Emergency Department, Abdulhamid Al Hinai, Laila Al Yazidi, Sanjay Jaju, Nasser Al Sidairi, Khalil Al Habsi, Mohammed Al Lawati, Saeed Al Obeidani

Sultan Qaboos University Medical Journal

Objective: Carboxyhaemoglobin (COHb), which represents the fraction of carbon monoxide bound to haemoglobin, is available as a point-of-care test in the emergency department. This study aimed to assess the role of COHb in the diagnosis of invasive bacterial infections (IBI) in a paediatric emergency department. Methods: This retrospective study examined a single reading of venous COHb values in otherwise healthy neonates who presented with febrile illness at the paediatric emergency department at Royal Hospital, Muscat, Oman, between December 2019 and December 2022. The optimal COHb level for the diagnosis of IBI was determined using receiver operating characteristic curve …

Cervical Deciduosis In Early Pregnancy Mimicking Malignancy: A Report Of Two Cases, Ajit Sebastian, Nada Salih, Shiby Jose, Tamima Al Dughaishi, Vaidyanathan Gowri

Sultan Qaboos University Medical Journal

Deciduosis is a benign condition characterised by the transformation of subepithelial connective tissue into decidual-like cells, typically occurring in response to hormonal changes during pregnancy. Although benign, cervical deciduosis may macroscopically resemble malignant lesions, leading to diagnostic uncertainty. This report presents two cases of cervical deciduosis diagnosed in early pregnancy. Both patients presented with first-trimester vaginal bleeding, and speculum examination revealed extensive wart-like lesions covering the cervix. Histopathological examination of cervical biopsies confirmed decidual changes. In pregnant women presenting with threatened miscarriage, a thorough local examination and biopsy of atypical cervical lesions are essential to exclude malignancy. As cervical deciduosis …

From Deficit To Asset: Developing An Equitable Early Warning System For Ninth Grade Success, Stephanie Mann

Electronic Theses and Dissertations

I explored the design and implementation of an asset-based Early Warning System (EWS) to support ninth-grade students at The Academy, a PK-12 charter school, during their critical high school transition. Using Practical Action Research, I addressed the question: How might a comprehensive EWS leverage student assets and systemic support to ensure success? Over one academic year, the study unfolded in two phases: Phase I employed qualitative methods—interviews, focus groups, and data reviews—to identify gaps, while Phase II developed an enhanced EWS, integrating map and street data for richer student profiles and staff collaboration. Findings underscore a human-powered EWS rooted in …

Building Media Literacy In Adolescence: A Cognitive Behavioral Clinician's Manual To Combat Misinformation And Misdiagnosis During Sessions, Patricia Sacchetti

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This paper examines the role of Cognitive Behavioral Therapy (CBT) in countering misinformation that youth encounter on social media and other informal sources, with the goal of creating a manual for mental health clinicians. The use of CBT by clinicians working with adolescents to combat the issue of misinformation and misdiagnosis has received little attention in the literature. Mental health clinicians’ knowledge of media literacy as a psychological construct can foster an effective treatment style by building upon the foundation of well-established theory and practice, such as CBT. CBT is a multifaceted treatment that can help guide mental health clinicians …

Overcoming Barriers To Connection Between People With Schizophrenia And Their Caregivers, Sarah G. Fernandez

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The purpose of this doctoral project is to bring together existing literature on relational barriers between patients and caregivers, and strategies for overcoming them, for one reason: to help clinicians facilitate connection within families and households where one person has schizophrenia. It is therefore comprised of two parts: this paper containing a three-part literature review on barriers to connection including social skill deficits characteristic of the disease of schizophrenia, environmental factors, and caregiver burden and expressed emotion within families, as well as protective factors and strategies for overcoming them. The second component of this project is a psychoeducational module geared …

Language Style Evaluation Validation For Implementation On Artificial Intelligence-Enhanced Augmentative And Alternative Communication Devices, Meghan A. Hunter

Theses and Dissertations

This study explored various methods of evaluating language style for integration into prompts designed for a sophisticated augmentative and alternative communication (AAC) device. A total of 395 individuals without a language disorder were recruited via a crowdsourcing platform to complete five surveys. The initial four surveys were designed to assess individuals' language style using different approaches (questionnaire developed with ChatGPT, self-written, questionnaire developed by Hartman and McCambridge, and choosing tags). Following the completion of these four surveys, a fifth survey was dynamically created based on the responses in the previous four surveys. Each possible response in the fifth survey was …

Fancy Mice, Damian Aguilar

University Honors Theses

In this proof-of-concept screenplay, a family becomes the subject of an isolating experiment that observes their behavior changes after remaining in their home for an extended period of time with all their basic needs met. The first twenty-pages of this psychological horror lays the foundation for a larger work that explores existential themes related to purpose, competition, and play.

How Did I Get Here? A Capstone Review, Michael Koach

University Honors Theses

In this thesis, I highlight my personal and professional growth as a college student. I use structured reflection and meta-analysis to uncover insights about how I learn and develop new skills. Over the past five years, I have built a toolbox of skills, including teamwork, public speaking, navigating uncertainty, strategic thinking, and leadership. I trace the development of each of these skills back to my coursework as a business student, my role in PSU's student-run advertising agency, and my professional experience. I show how these skills culminated in my business capstone project. My communication and leadership skills allowed me to …

Effect Of Ipv On Latino Children's Perspectives Of Fatherhood, Elizabeth Berks

University Honors Theses

Intimate partner violence (IPV) can be found in many cultures throughout the world, with varying levels of acceptability, victimization, and perpetration. Approximately one in five couples report experiencing at least one instance of IPV in a given year. Women are victims of IPV more frequently than men, and experience more severe injuries. 20% of women report a lifetime history of physical IPV victimization by their current or past partners. Further, women are also ten times more likely to be killed due to IPV than men are. Presently, empirical research literature surrounding the dynamics and impacts of IPV is heavily focused …

Intersectional Realities, Multi-Dimensional Films: Reading Julie Dash's Illusions As An Activist Text, Amelia Morrison

University Honors Theses

This paper reads Julie Dash's 1982 film Illusions as an activist text, which challenges dominant cinematic and historical narratives through its Black feminist perspective. It explores the cinematic and narrative devices that Dash uses--including the weaving of fantasy and history, the strategic use of period aesthetics, and masking--to expose and subvert the mechanisms of white supremacist and patriarchal hegemony within Hollywood. Drawing on intersectional feminist theory from scholars like Kimberlé Crenshaw, Patricia Hill Collins, and bell hooks, alongside cinematic theory, this analysis demonstrates how Illusions critiques the historical erasure of people of color from United States cinema and history. By …