Digital Commons Network^™

Biphasic Sleep Is A Feature Of Sleep Disturbance In Syngap1-Rd, Aida Doucoure, Het Patel, Mark A Abboud, Alice Sperry, Sarah K Wanigatunga, Deana Crocetti, Heather Volk, Adam P Spira, Stewart H Mostofsky, Vaishnav Krishnan, Constance Smith-Hicks

Faculty, Staff and Students Publications

Study objectives: Sleep problems are common in children with SYNGAP1-Related Disorder (SYNGAP1-RD). The use of devices that objectively estimate sleep are complicated by co-occurring sensory disorders in this population. We examined the feasibility and validity of wrist actigraphy to examine sleep and rest-activity rhythms (RAR).

Methods: Data from five children with SYNGAP1-RD and 42 typically developing children were analyzed. All children were asked to wear the Actiwatch-2 for 14 continuous days and caregivers were asked to complete a sleep diary and the Children Sleep Health Questionnaire (CSHQ). Parametric (alpha, beta, acrophase, amplitude, up/down mesor, mesor), nonparametric (intradaily variability, interdaily stability, …

Statistics Of Natural Scenes Shape Contextual Modulation In The Visual Cortex, Jiakun Fu, Suhas Shrinivasan, Luca Baroni, Zhuokun Ding, Paul G Fahey, Paweł A Pierzchlewicz, Nikos Karantzas, Kayla Ponder, Rachel Froebe, Lydia Ntanavara, Taliah Muhammad, Konstantin F Willeke, Eric Wang, Zhiwei Ding, Dat Tran, Stelios Papadopoulos, Saumil Patel, Jacob Reimer, Alexander S Ecker, Xaq Pitkow, Jan Antolik, Fabian H Sinz, Ralf M Haefner, Andreas S Tolias, Katrin Franke

Faculty, Staff and Students Publications

Vision is context dependent, with neuronal responses shaped not only by local features but also by surrounding visual input. While classical studies, using grating stimuli, show that iso-oriented surrounds suppress responses more than orthogonal surrounds, the role of contextual modulation under natural stimulus conditions remains less clear. Using recordings from mouse primary visual cortex (V1), we trained convolutional neural network models to predict neuronal responses to natural images and synthesized surround stimuli that selectively suppressed or facilitated responses to optimal center inputs. In vivo experiments confirmed these predictions. Facilitatory surrounds resembled naturalistic continuations of the optimal center stimulus, consistent with …

“We're Just Relics Of A Bygone Era!”: The Portrayal Of Librarians In Short Films, Alessandro Camarra

Staff publications

While on the hunt for examples of "librarian" characters portrayed in popular culture, it can be thrilling when said characters make an appearance in feature length films or Hollywood blockbusters. However, sometimes a higher level of satisfaction can be found when examples come from smaller, more personal, projects.

One person films a three-minute clip of their friend wearing glasses and a fake "bun" wig, then uploads it to YouTube. Another person works all semester on a half-hour documentary of their university library, then submits it as the final project for their Film Studies class. Not to mention examples that go …

Development Of An Educational Curriculum For The Surgical Implantation Of Dbs Systems, David Bieber, Rany T Abdallah, Alaa Ab-Elsayed, Adam R Burkey, Dario J Englot, Kunal Gupta, Charles N Munyon, Casey H Halpern, Kai J Miller, Joshua M Rosenow, Ahmed M Raslan, Konstantin V Slavin, Jennifer A Sweet, Sameer Sheth, Nestor Tomycz, Ashwin Viswanathan, Chengyuan Wu, Jeffrey S Raskin

Faculty, Staff and Students Publications

Background: Deep-brain stimulation (DBS) systems are implanted for movement disorders, epilepsy, and psychiatric conditions. Neurologic surgery remains the only discipline credentialed to implant DBS devices, although significant practice variation exists, partly due to heterogeneous training. The North American Neuromodulation Society (NANS) education committee offers a granular recommendation for the progression of an early learner through the practitioner level. It is contextualized within the six-core competency rubric for the surgical implantation of DBS devices.

Materials and methods: Guided by the Accreditation Council for Graduate Medical Education (ACGME) core competencies, a subcommittee of the NANS education committee met virtually and in-person over …

A Nationwide Central Diagnosis For Pediatric Cns Tumors In Japan: The Jccg Brain Tumor And Pathology Committees, Yoshiko Nakano, Junko Hirato, Takako Yoshioka, Tetsuya Takimoto, Sumihito Nobusawa, Kaishi Satomi, Ran Tomomasa, Seiji Yamada, Taku Homma, Shoh Sasaki, Ayako Yamazaki, Maki Sakaguchi, Yasuhide Takeuchi, Nei Fukazawa, Kai Yamasaki, Kohei Fukuoka, Yui Shinohara Kimura, Yuki Nagayama, Yohei Inoue, Akira Miyahira, Ema Yoshioka, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Yuko Hibiya, Yuko Matsushita, Mai Honda Kitahara, Yuki Yomoda, Miho Kato, Michael D Taylor, Yasuhito Arai, Tatsuhiro Shibata, Hiroaki Sakamoto, Keita Terashima, Yoshiki Arakawa, Toshihiro Kumabe, Ryo Nishikawa, Junichi Hara, Yonehiro Kanemura, Koichi Ichimura

Faculty, Staff and Students Publications

In 2016, the Japan Children's Cancer Group launched a nationwide research initiative to provide central diagnosis incorporating pathology review and molecular profiling for pediatric central nervous system (CNS) tumors. Over the first eight years, 2224 cases were registered. Non-next-generation sequencing analyzes, such as pyrosequencing and NanoString, were routinely performed, mainly for glioma, medulloblastoma, and ependymoma. Additional analyzes, including methylation profiling and RNA sequencing, were conducted for selected diagnostically challenging cases. The most common diagnoses were low-grade glioma (26%), medulloblastoma (18%), germ cell tumor (16%), high-grade glioma (12%), and ependymoma (11%). Diagnostic or targetable alterations were detected in nearly half of …

Study Of Onshore And Offshore Upwind And Downwind Wind Turbine Configurations: Performance Differences And Aerodynamic Characteristics, Ahmed Ismail

Mechanical Engineering Theses

The aerodynamic performance and loading behavior of large- scale wind turbines depend heavily on atmospheric inflow conditions and rotor orientation. While upwind turbines remain the most common design in the industry, recent progress in materials, aeroelastic modeling, and control systems has sparked renewed interest in downwind configurations. This study aims to assess how ABL characteristics and rotor orientation affect the aerodynamic performance of a utility- scale wind turbine. A CFD framework was built in ANSYS Fluent to model the NREL 5 MW Reference Wind Turbine. Transient simulations employed the SST k–ε turbulence model under various inflow conditions: uniform, onshore, and …

Alumni Journal - Volume 97, Number 2, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Editorials
2 | From the Editor
4 | From the President
6 | From the Dean

News
8 | School of Medicine News
10 | Alumni News
14 | Students: AI-HEAL
15 | Paying It Forward Scholarship
16 | This & That
18 | Department Report: Cardiothoracic Surgery
20 | AIMS Report: Gleaning Missions Blessings at Hôpital Adventiste d’Haïti
22 | AIMS News

Graduation 2026
24 | Graduation Feature: A celebration of the class of 2026

Features
42 | By the Graduates: Stories and reflections
48 | Richard H. Hart '70, DrPH: Reflections on Hart's Legacy Upon Retirement
53 | …

Public Perceptions Regarding Fire And Fuel Mitigation, Jennifer Schmidt, Kathryn Davis, Nicholas Link, Joseph Little

ISER Reports

In fall 2025, UAA researchers held focus groups to talk to Anchorage municipality residents about their attitudes towards a wildfire mitigation technique called fuel treatments. Findings indicated residents support fuel treatments, but had questions about aesthetic and environmental implications, financial barriers, and the policy process.

Sunshine Pump: A Trailer-Mounted Solar Powered Water Pump System, Dylan Quan Dinh, Duncan Campbell

Electrical Engineering

The Sunshine Pump is a trailer-mounted, off-grid solar powered water pumping system that delivers approximately 1,000 gallons of water per day from a well of approximately 250 feet total dynamic head to an above-ground storage tank on a rural ranch in Los Osos, California. The system captures solar energy with a 1,500 watt photovoltaic array consisting of four 375 watt panels wired in series, regulates that energy through a maximum power point tracking stage integrated into an all-in-one inverter/charger, stores it in a 4,800 watt-hour LiFePO4 battery, and converts it to 230 volt AC power to drive a 0.75 horsepower …

Asynchronous Transitions From High-Risk Hepatoblastoma To Carcinoma, Xinjian Yu, Stephen Sarabia, Martin Urbicain, Sonal Somvanshi, Roma Patel, Priyanka Rao, Tuan M Tran, Yen-Ping Yeh, Keng-Shih Chang, Yi-Tzu Lo, Jessica Epps, Kathleen A Scorsone, Hua-Sheng Chiu, Emporia Faith Hollingsworth, Cintia R Perez, Mohammad Javad Najaf Panah, Barry Zorman, Jordan Muscal, Milton J Finegold, John A Goss, Rita Alaggio, Angshumoy Roy, Kevin E Fisher, Andras Heczey, Sarah Woodfield, Sanjeev Vasudevan, Kalyani Patel, Ting-Wen Chen, Dolores Lopez-Terrada, Pavel Sumazin

Faculty, Staff and Students Publications

Background & aims: Most pediatric hepatocellular tumors are classified as hepatoblastoma (HB) or hepatocellular carcinoma (HCC), yet a subset exhibits mixed histological and molecular features. These hepatoblastomas with carcinoma features (HBCs) include cases provisionally designated as hepatocellular neoplasm-not otherwise specified (HCN-NOS). Their biology remains poorly understood, with unresolved questions about their cellular composition and outcomes. It is unclear whether HBCs comprise hybrid cells with combined HB and HCC characteristics (HBC cells) or admixtures of distinct HB and HCC cells. We characterized the biology, etiology, cellular composition, and evolutionary dynamics of HBCs.

Methods: We performed multi-omics profiling - including single-nucleus RNA …

Blinded, Bias-Controlled Multi-Rater Evaluation Of Human-Versus-Ai Brain Metastasis Segmentation Using A Hybrid Foundation-Model Framework, Yiding Han, Enze Zhu, Mhd Hasan Ai Mekdash, Omar Awad, Piyush Pathak, Shixiao Liang, Daniel Allan Hamstra, Xizhe Zhang, Zaid Ali Siddiqui, Baozhou Sun

Faculty, Staff and Students Publications

Background: Accurate segmentation of brain metastases (BM) is essential for diagnosis, stereotactic radiosurgery planning, and longitudinal assessment. However, manual contouring is time-intensive, limiting clinical scalability, and exhibits substantial inter-observer variability. This variability complicates objective assessment of automated segmentation methods and challenges interpretation of model performance.

Purpose: To address these limitations, we developed TUM-SAM, a hybrid foundation-model framework for fully automated BM segmentation, and introduced a bias-controlled, blinded multi-rater evaluation paradigm to determine whether AI-based BM segmentation has reached expert-level performance and whether AI-generated contours are preferred by human experts under unbiased assessment.

Methods: TUM-SAM integrates nnU-Net-based lesion detection with a …

Mechanisms Coordinating Exit From The Stem Cell State In Mammals, Emily J Park, Florencia Levin-Ferreyra, Bruno Di Stefano

Faculty, Staff and Students Publications

Differentiation requires coordinated exit from the stem cell state, during which gene regulatory networks sustaining self-renewal are dismantled, while lineage-specific programs are activated. This transition is governed by chromatin modifications, transcriptional networks, RNA processing, translational control, and metabolic rewiring that must operate with temporal precision. Despite significant progress in identifying individual regulatory components, understanding how these layers integrate to orchestrate irreversible cell fate commitment remains a fundamental challenge. This review examines common and unique regulatory principles governing stem cell exit, from totipotency during early embryogenesis to tissue-specific stem cell differentiation in adults. We synthesize recent findings on regulatory mechanisms across …

“A Place For Every Book, Every Book In Its Place … ”: The Portrayal Of Librarians In Video Games, Alessandro Camarra

Staff publications

The role of "librarian" can follow several well-worn tropes within the world of interactive media. These can be referred to as:

*The All-Knowing Guide (teaches the player how to actually play the game, i.e. accessing the inventory menu or revealing which button combination will unlock the ability to cast spells)

*The Lore Keeper (provides exposition and backstory about the game world to the player)

*The Clueless Collector (begs the player for help recovering lost/overdue books)

*The Secret Sexpot (an object of desire for the player to romance/seduce)

*The Unforgiving Tyrant (demands silence at all costs)

And then we have those …

Enhancing Care Coordination Between The Same Day Clinic (Sdc) And Primary Care Group (Pcg) By Facilitating Care Establishment With A Primary Care Provider (Pcp), Saba Zabarah

Doctor of Nursing Practice Final Project Abstract

PURPOSE

The purpose of this Quality Improvement (QI) project was to connect patients to a Primary Care Provider (PCP). The specific aim was to increase by 25% the percentage of patients without a PCP who established care with a PCP within 30 days of visiting the Same Day Clinic (SDC).

BACKGROUND

The SDC provides episodic care for acute illness, making it difficult to coordinate care for patients who do not have a PCP and require follow-up. The project was implemented in an outpatient clinic that is connected to a larger primary care group in Houston, Texas.

METHODOLOGY

The intervention included …

Jenny E. Carroll, Jenny E. Carroll

Faculty CVs

No abstract provided.

Terri L. Helge, Terri Lynn Helge

Faculty CVs

No abstract provided.

Milan Markovic, Milan R. Markovic

Faculty CVs

No abstract provided.

Tanya Pierce, Tanya Pierce

Faculty CVs

No abstract provided.

Kristen Rowlett, Kristen Rowlett

Faculty CVs

No abstract provided.

Aric K. Short, Aric K. Short

Faculty CVs

No abstract provided.

Joan Stringfellow, Joan Stringfellow

Faculty CVs

No abstract provided.

Sara Zampierin, Sara Zampierin

Faculty CVs

No abstract provided.

Stephanie J. Thompson, Stephanie J. Thompson

Faculty CVs

No abstract provided.

Lawrence B. Solum, Lawrence B. Solum

Faculty CVs

No abstract provided.

Eric H. Martinez, Eric H. Martinez

Faculty CVs

No abstract provided.

Felix Mormann, Felix Mormann

Faculty CVs

No abstract provided.

Karon L. Rowden, Karon L. Rowden

Faculty CVs

No abstract provided.

Numerical Investigation Of Shock-Induced Deformation Of Bubble-Laden Droplets, Juan Roldan

Doctoral Dissertations and Master's Theses

Rain impact can be a source of surface erosion on hypersonic vehicles, and the severity of each impact depends on droplet velocity, mass, and final shape, all of which are set by how the droplet breaks up under shock loading. Real droplets are expected to carry entrained non-condensable gas (NCG) nuclei from their formation. This dissertation investigates whether the purely mechanical, pressure-driven response of these nuclei, independent of vaporization, is large enough to measurably alter the internal pressure field and early deformation of a shock-loaded droplet.

The droplet and surrounding gas are modeled with a compressible, diffuse-interface, axisymmetric Eulerian framework …

Mathematical Methods For Engineering And Physics, Andrei Ludu

OER Main

Imagine if you could see the hidden laws that shape everything around us—engineered structures, natural phenomena, even the technology we use every day. Wouldn’t you want to harness this knowledge to create groundbreaking engineering solutions that impact the world?

My young, bright engineering friends. In an age where codes, software, and artificial intelligence promise solutions at the click of a button, you wonder – why should I invest my precious time and brainpower struggling with abstract theorems and unworldly equations? You might be asking why deep math is still relevant, especially in an age dominated by sophisticated technology. Whether …

Robert B. Ahdieh, Robert B. Ahdieh

Faculty CVs

No abstract provided.