Digital Commons Network^™

Proteomic-Based Stemness Score Measures Oncogenic Dedifferentiation And Enables The Identification Of Druggable Targets, Iga Kołodziejczak-Guglas, Renan L S Simões, Emerson De Souza Santos, Elizabeth G Demicco, Rossana N Lazcano Segura, Weiping Ma, Pei Wang, Yifat Geffen, Erik Storrs, Francesca Petralia, Antonio Colaprico, Felipe Da Veiga Leprevost, Pietro Pugliese, Michele Ceccarelli, Houtan Noushmehr, Alexey I Nesvizhskii, Bożena Kamińska, Waldemar Priebe, Jan Lubiński, Bing Zhang, Alexander J Lazar, Paweł Kurzawa, Mehdi Mesri, Ana I Robles, Clinical Proteomic Tumor Analysis Consortium, Li Ding, Tathiane M Malta, Maciej Wiznerowicz

Faculty, Staff and Student Publications

Cancer progression and therapeutic resistance are closely linked to a stemness phenotype. Here, we introduce a protein-expression-based stemness index (PROTsi) to evaluate oncogenic dedifferentiation in relation to histopathology, molecular features, and clinical outcomes. Utilizing datasets from the Clinical Proteomic Tumor Analysis Consortium across 11 tumor types, we validate PROTsi's effectiveness in accurately quantifying stem-like features. Through integration of PROTsi with multi-omics, including protein post-translational modifications, we identify molecular features associated with stemness and proteins that act as active nodes within transcriptional networks, driving tumor aggressiveness. Proteins highly correlated with stemness were identified as potential drug targets, both shared and tumor …

Plug And Coil Procedure For Management Of Large Postinfarct Ventricular Septal Defect, Hussam Al Hennawi, Sergio Flores, Michael Little, Lacy Harville, Ahmad Almomani, Muhammad Hammadah

Abington Jefferson Health Papers

Acute surgical mortality for postinfarction ventricular septal rupture remains alarmingly high at approximately 50%. In comparison, medical mortality is nearly 100% and likely exceeds historical levels because of the declining frequency of these acute surgeries, with many surgeons now performing fewer than 1 or 2 annually. Percutaneous device closure has become a feasible option for managing postinfarction ventricular septal defects in carefully selected patients. However, this technique may be associated with challenges such as significant residual shunting, delayed endothelialization, hemolysis, and extended hospital stays. Here, we present a novel approach using coil packing to enhance closure and reduce shunting.

Disentangling The Channels Of Impact Of The Ukraine War On Global Food Markets: An Integrated Scenario Approach, Maksym Chepeliev, Maryla Maliszewska, Maria Filipa Seara E Pereira

Department of Agricultural Economics Faculty Publications

The war in Ukraine has major implications for the world's agricultural and food markets, as the Black Sea region is a large supplier of crops and fertilizers. Impacts of the war are further exacerbated by the sanctions against Russia, spillover effects from disruptions of other commodity markets, adverse weather events and domestic policies that countries around the world have implemented in pursuit of food security. In this paper, using a comprehensive modeling framework, we decompose the impacts across various channels and show that the cumulative effect of the considered indirect spillovers is even more substantial than the direct agricultural supply …

Christian Beliefs About Salvation: Measurement And Associations With Mental Health And Well-Being, Anthony Edward Rose, Timothy B. Smith

Faculty Publications

Religious beliefs influence many behaviors and perspectives relevant to wellbeing and mental health. In Christianity, beliefs about how one attains salvation may be particularly relevant to psychology, but limited scholarship has considered cognitive aspects of religiosity. This study developed and evaluated a new measure of Beliefs about Salvation (BAS) that assesses affirmations of salvation (a) by God’s grace alone and (b) by God’s grace after human repentance/ordinances, as understood by different Christian denominations. We examined the association of the BAS with three measures of mental health and six measures of influences on religiosity. In a sample of 1556 predominantly members …

Lindenwood Digest, June 11, 2025, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Green Technologies For Isolating Bioactives From Plant-Based Food And Their Applications In Human Health And Longevity, Vibha Gajbe, Azza S. Naik, Roji Waghmare, Shuchi Midha

Research Outputs: 2025-Present

No abstract provided.

Assessment Of Walkability Of University Campus And Communities: Associations With Perceived Safety & Student Retention, Wendy Bjerke

Exercise Science Faculty Publications

Introduction: Approximately 80% of Americans do not meet minimum guidelines for regular physical activity. Among ways to promote physical activity is to optimize the Built Environment to promote and increase access to walking and cycling. Walkable and accessible university campus environments and proximal communities can promote physical activity and are assessed and compared in this study. Purpose and Methods: Approximately 20 million students attend colleges and universities in the United States with over 100,000 students enrolled in the state of Connecticut. These students can potentially engage in physical activity within a campus or around the surrounding communities for university related …

The Multifunctional Ascorbate Peroxidase Moapx1 Secreted By Magnaporthe Oryzae Mediates The Suppression Of Rice Immunity, Muxing Liu, Ziqian Guo, Jiexiong Hu, Yuke Chen, Fang Chen, Weizhong Chen, Wenya Wang, Boyang Ye, Zhixiang Yang, Gang Li, Xinyu Liu, Haifeng Zhang, Ping Wang, Zhengguang Zhang

School of Graduate Studies Faculty Publications

Fungi secrete effector proteins, including extracellular redox enzymes, to inhibit host immunity. Redox enzymes have been hypothesized to inhibit host reactive oxygen species (ROS); however, how they suppress host immunity remains unknown. We characterized an extracellular ascorbate peroxidase (MoApx1) that is secreted into rice chloroplasts by the rice blast fungus Magnaporthe oryzae. MoApx1 displays multifunctional capabilities that significantly contribute to fungal virulence. Firstly, MoApx1 neutralizes host-derived H2O2 within the chloroplast through its peroxidase activity, thereby inhibiting chloroplast ROS (cROS)-mediated defense responses. Secondly, MoApx1 targets the photosystem I subunit OsPsaD, disrupting photosynthetic electron transport to further suppress cROS production. Most importantly, …

The Critical Plastocapillary Number For A Newtonian Liquid Filament Embedded Into A Viscoplastic Fluid, Mohammad Tanver Hossain, Wonsik Eom, Arjun Shah, Andrew Lowe, Douglas Fudge, Sameh H. Tawfick, Randy Ewoldt

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The yield stress of a viscoplastic material can stabilize an embedded fluid tunnel against capillarity-induced breakup, enabling remarkable technologies such as embedded 3D printing of intricate, freeform, and small components. However, there is persistent disagreement in the published literature between the observed minimum stable diameter, 𝑑min, and the theoretical plastocapillary length 𝑝𝑐 = 2𝛤∕𝜎𝑦, with interfacial tension 𝛤 and bath yield stress 𝜎𝑦, leading to a prior hypothesis that the apparent surface tension 𝛤 is much smaller to enforce 𝑑min = 𝑝𝑐 . Here we introduce and experimentally test a new hypothesis that the critical diameter is set by the …

Nurturing Belonging: A Qualitative Study Of Participation In A Gardening Group For People Living With And Beyond Cancer, Melissa Jacobs, Kerryann Steele, Alison Warren

School of Health Professions

PurposeThe incidence of cancer is increasing globally and engagement in meaningful occupations is fundamental for people living with and beyond cancer. There is a growing body of evidence regarding the health and well-being benefits of engaging in nature-based occupations, however, there is limited evidence specific to this population. This study aims to explore the experiences of engaging in Blooming Well, a gardening group created to provide opportunities for people recovering from or living with cancer.Design/methodology/approachA qualitative case study methodology was used to explore perspectives of both group leaders and participants of the Blooming Well group. Study participants included two group …

Draft Final 2025 Residential Metals Abatement Program (Rmap) Quality Assurance Project Plan (Qapp) Annual Update (Non-Residential Parcels And Residential Daycares), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests On Respiratory And Stool Samples With Or Without Lateral Flow Lipoarabinomannan Assays To Detect Pulmonary Tuberculosis Disease In Children, Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, Mathias Weis Damkjær, Alexander W Kay, Johanna Åhsberg, Ruvandhi R Nathavitharana, Ian Schiller, Nandini Dendukuri, Andreas Lundh, Maunank Shah, Stephanie Bjerrum, Devan Jaganath

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular assays widely used to diagnose tuberculosis disease in children. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended for use amongst children with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM separately in children, but in clinical practice the tests may be used concurrently, i.e. in 'parallel'.

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory and stool specimens in children, and with LF-LAM on urine amongst children with HIV, versus each assay alone for detecting pulmonary tuberculosis disease.

Search …

Mapping Vascular Network Architecture In Primate Brain Using Ferumoxytol-Weighted Laminar Mri, Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C Van Essen, Takuya Hayashi

2020-Current year OA Pubs

Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain's microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate (ΔR

Role Of Glucuronoxylomannan And Steryl Glucosides In Protecting Against Cryptococcosis, Gabriel Soares Matos, Tamara L Doering, Et Al.

2020-Current year OA Pubs

The development of vaccines for fungal diseases, including cryptococcosis, is an emergent line of research and development. In previous studies, we showed that a

On Capitol Hill, Nyls Students Advance Legislative Advocacy Efforts, Joanne Doroshow

NYLS Community News

No abstract provided.

Higher-Order Exceptional Points In A Non-Reciprocal Waveguide Beam Splitter, Hamed Ghaemidizicheh, Shahram Dehdashti, Andreas Hanke, Ahmed Touhami, Janis Nötzel

Physics & Astronomy Faculty Publications

Non-Hermitian systems have attracted significant interest because of their intriguing properties, including exceptional points (EPs), where eigenvalues and the corresponding eigenstates coalesce. In particular, quantum systems with EPs exhibit an enhanced sensitivity to external perturbations, which increases with the order of the EP. Therefore, higher-order EPs hold significant potential for advanced sensing applications, but they are challenging to achieve due to stringent symmetry requirements. In this work, we study the dynamics of a generalized lossy waveguide beam splitter with asymmetric coupling by introducing non-reciprocity as a tunable parameter to achieve higher-order EPs even without dissipation. Moreover, we analyze the evolution …

The Incidence Of Peripartum Invasive Group A Streptococcal Infections And Association With Illicit Drug Use, Elizabeth Wagman, Elizabeth Wagman, Rupsa Boelig, Sarah Boudova

Department of Obstetrics and Gynecology Faculty Papers

No abstract provided.

Effect Of Post-Operative Clothing, Bandage, And Collar Application On Stress After Ovariohysterectomy In Cats, Çağatay Esin, Seba Raouf, Gülşah Saral, Büşra Uzun

The Thai Journal of Veterinary Medicine

Ovariohysterectomy is a common surgical procedure in veterinary medicine, not only for reproductive control but also for conditions like pyometra, metritis, mammary tumors, and other reproductive disorders. Pain in cats occurs as a response of the body and is accompanied by various physiological and behavioral changes. Pain in cats, though prevalent, is often under-recognized and inadequately treated. The Glasgow pain scale is a psychometrically designed tool for assessing acute pain in veterinary patients. Serotonin (5-HT), a biogenic monoamine derived from tryptophan, functions as a mood-regulating neurotransmitter and may decrease following surgical interventions. This study aimed to evaluate post-operative pain and …

On The Concepts Of Culture, Education, And Language, Augusto Boal

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No abstract provided.

On The Concepts Of Modern And Archaic, Augusto Boal

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No abstract provided.

Joker Forum Theatre As A Classroom Teacher: Qualitative Research Data., Nadarajan Thambu

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

The task of maintaining the focus and interest of students on the teaching and learning process in the classroom is still a challenge for teachers of Moral Education subject. Students who do not pay attention, cannot understand moral values, accept and show commitment to them. The failure of students to focus will also fail the effort to produce moral human beings. Meanwhile, the role of theater in the field of education is also undeniable. Therefore, a form of community theater named Forum Theatre has been used as a pedagogy of teaching Moral Education among preservice teachers. In the context of …

The Very Fine Line: Utilitarian Aesthetics And Threshold Politics In Now You See Me Moria, Nik Rye

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

Now You See Me Moria (est. August 2020) is an international socially engaged art collective that brings visibility to the inhumane conditions of the Moria refugee camp, aiming to influence European Union migration policies. This paper examines the collective’s work across digital and physical gallery spaces, analyzing the role of utilitarian aesthetics in both image and process, and situating the project alongside the migratory journey of a specific member. The resonance of this initiative, and the actions it has catalyzed, reveals a societal push to disrupt the contemporary art mainstream in favor of an emergent movement that privileges lived experience …

This Is Theatre: Deconstructed Repetition And Theatre-In-Education During Covid-19, Subbah Mir

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

This project report is a practical application of deconstructed repetition model, I devised by merging Augusto Boal and Baz Kershaw, in an undergraduate Composition Writing class in Louisiana State University, Baton Rouge, U.S. As the facilitator Deconstructed repetition means cost-effective repetition of personal and local stories for introspection in order to engage the community members, address the oppression, and celebrate the local culture. The four stipulations of the models are: avoiding the Western canon (or hegemonic voice), making the audience(s) see direct and indirect oppression, circumventing commodification while maintaining audience interest, and celebrating local culture instead of downright criticizing it. …

Isto É Teatro: Repetição Desconstruída E Teatro Na Educação Durante A Covid-19, Subbah Mir

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

Neste artigo, discuto o uso do círculo de narrativas (Roadside Theatre, 1999) denominado como um "modelo de repetição desconstruída" para o ativismo comunitário, capaz de conectar os problemas pessoais dos alunos com as questões sociais/comunitárias. Iniciei este projeto com um curso síncrono online de Redação de Textos para alunos de graduação. Ao final do semestre, os alunos participaram dinamicamente do ativismo comunitário por meio da exploração de questões socio-pessoais, o que levou a diversas iniciativas empreendidas posteriormente pelo Grêmio Estudantil da universidade. Este projeto foi conduzido para testar o Modelo de Repetição Desconstruída desenvolvido como uma ferramenta eficaz de ativismo …

O Que Há De Tão Engraçado No Teatro Do Oprimido?, Jennifer Schaupp

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

Este artigo analisa meu workshop virtual da Conferência Pedagogia e Teatro do Oprimido de 2023, no contexto da comédia e da corporeidade. Considera as atividades que facilitei e suas origens, juntamente com minha percepção da reação dos participantes, para que outros educadores e facilitadores as adaptem às suas próprias experiências educacionais.

What's So Funny About Theatre Of The Oppressed?, Jennifer Schaupp

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

This article examines my 2023 Pedagogy and Theatre of the Oppressed Conference virtual workshop within the framework of comedy and embodiment. It considers the activities I facilitated and their origins along with my perception of participant reaction for other educators and facilitators to adapt for their own educational experiences.

Enraizados No Amor E Na Solidariedade: Acampamentos Estudantis Por Uma Universidade Popular, Robin Brandehoff

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No semestre acadêmico do outono de 2023, universidades em todo o país testemunharam uma onda de acampamentos estudantis pedindo o cancelamento de verbas universitárias a Israel e suas operações militares (Reeve, 2023). Esses acampamentos incitaram prisões de estudantes, professores e membros da comunidade acadêmica; brigas violentas entre manifestantes e contramanifestantes mascarados; e cancelamentos de formaturas universitárias para a geração da COVID-19 que também não conseguiu vivenciar a formatura do ensino médio. No entanto, esses acampamentos também criaram aulas no campus, oportunidades para alunos e administradores aprenderem uns com os outros e para a construção de comunidades no campus que se …

Rooted In Love And Solidarity: Student Encampments For A Popular University, Robin Brandehoff

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

In the spring academic semester of 2024, universities across the nation saw an uptick of student encampments asking for a divestment of university funds from Israel and its military operations (Reeve, 2023). These encampments have incited arrests of students, faculty, and community members; violent brawls between protesters and masked counter-protesters; cancellations of university graduations for the COVID-19 generation who did not get to experience their high school graduation either—and yet these encampments have also created on-campus teach-ins, opportunities for students and administrators to learn from another, and for the building of campus communities which extend beyond the classroom and school-sanctioned …

People Powered Legislative Theatre Playbook: O Sonho, A Jornada, Os Meios, Oluchi Igili, Katy Rubin

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No abstract provided.

People Powered Legislative Theatre Playbook: The Dream, The Journey, The Resource, Oluchi Igili, Katy Rubin

Spect-actor: A Journal of Pedagogy & Theatre of the Oppressed

No abstract provided.