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Articles 17131 - 17160 of 5149626
Full-Text Articles in Entire DC Network
Absorption Characteristics Of A Passive Damper-Augmented Timoshenko Beam Using A Wave-Decomposition Approach, Samikhshak Gupta, Vijaya Venkata Narasimha Sriram Malladi
Absorption Characteristics Of A Passive Damper-Augmented Timoshenko Beam Using A Wave-Decomposition Approach, Samikhshak Gupta, Vijaya Venkata Narasimha Sriram Malladi
Michigan Tech Publications
Local impedance variations in structural waveguides partially reflect and absorb incidentflexural waves, motivating wave-based strategies for passive vibration control. This studydevelops and experimentally validates a wave-energy framework to quantify and optimizeflexural wave absorption by Kelvin–Voigt attachments on a finite Timoshenko beam.A finite element model is validated against Scanning Laser Doppler Vibrometry measurementsfrom a clamped–clamped aluminum beam with a passive damper mounted nearone end, with dashpot parameters identified through two independent approaches andthe discrepancies attributed to parameter uncertainty. Wave decomposition of the simulatedand measured velocity fields yields the power reflection coefficient ρ(ω) and powerabsorption coefficient α(ω) over the 0–15.3 kHz band. …
Ms4 Swmpp 2026, John Kay
Ms4 Swmpp 2026, John Kay
Municipal Separate Storm Sewer System (MS4) Permit
Stormwater discharges from Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Municipal Separate Storm Sewer System (MS4) Permit. This Stormwater Management Plan (SWMP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM.
Co-Designing Multimodal, Multilingual Text Sets: Centering Caregiver Choice, Katie M. Crook, Emily Howell, Lindsey W. Rowe, Hazel Vega Quesada, C. C. Bates
Co-Designing Multimodal, Multilingual Text Sets: Centering Caregiver Choice, Katie M. Crook, Emily Howell, Lindsey W. Rowe, Hazel Vega Quesada, C. C. Bates
Publications
Early literacy instruction in the U.S. often centers monolingual, English-dominant practices that marginalize multilingual learners and their families. This qualitative design-based research study examines a family literacy initiative that engaged caregivers and teachers as co-designers of a multilingual, multimodal literacy resource bag. Using the MultiSemiotic Architecture Framework, we analyzed qualitative data to explore how collaborative text selection can advance linguistic justice in early childhood education. Findings highlight five themes that shaped intentional text selection and supported multilingual home literacy practices: content, language, cultural relevance, curricular alignment, and collaborative modifications. By centering families' cultural and linguistic resources, the project disrupted monolingual …
Career Pathways Program Annual Report For Ay 2025/26, Wie Yusuf
Career Pathways Program Annual Report For Ay 2025/26, Wie Yusuf
Career Pathways
Career Pathways launched in August 2017 as the university-wide initiative to provide career and professional development to graduate students. It encompasses both the Preparing Future Faculty (PFF) and the Preparing Future Professionals (PFP) Certificates. The Preparing Future Faculty Certificate was established in 2007, while the Preparing Future Professionals Certificate was launched in 2017, concurrently with the introduction of Career Pathways. The Career Pathways program prepares graduate students for a successful transition into thriving careers. With the PFP Certificate, the emphasis has been on addressing the existing gap in career and professional development for master’s and doctoral students with career plans …
Msw Portfolio: Through Courage And Heart, Meghan N. Conklin
Msw Portfolio: Through Courage And Heart, Meghan N. Conklin
Graduate Student Portfolios, Professional Papers, and Capstone Projects
This portfolio discusses my journey through the MSW program highlighting anti-oppressive frameworks, ethics, trauma informed care, and indigenous practice. This portfolio displays how I met the core competencies of advanced integrative practice with a focus on practice with youth in and out of institutional setting.
Math 119: Math For Elementary School Teachers Syllabus, Seth Lehman
Math 119: Math For Elementary School Teachers Syllabus, Seth Lehman
Open Educational Resources
OER course syllabus for Math 119, Math for Elementary School Teachers, at Queens College
Office Of The Attorney General And Reporter, July 2026, Tennessee. Comptroller Of The Treasury.
Office Of The Attorney General And Reporter, July 2026, Tennessee. Comptroller Of The Treasury.
Performance Audit Reports
No abstract provided.
State And Regional Variation In Access To Pediatric Extracorporeal Membrane Oxygenation., Allan M. Joseph, Andrew J. Lautz, Carlie N. Myers, Ranjit S. Chima, Juan P. Gurria, Shafee Salloum, Wendy Hasson, Matthew P. Malone, Jenna Miller, Reanna Smith, Maya L. Dewan
State And Regional Variation In Access To Pediatric Extracorporeal Membrane Oxygenation., Allan M. Joseph, Andrew J. Lautz, Carlie N. Myers, Ranjit S. Chima, Juan P. Gurria, Shafee Salloum, Wendy Hasson, Matthew P. Malone, Jenna Miller, Reanna Smith, Maya L. Dewan
Manuscripts, Articles, Book Chapters and Other Papers
Extracorporeal membrane oxygenation (ECMO) is only available in specialized medical centers. We conducted a geospatial analysis and found state- and region-level variation in the supply of ECMO centers, and the number of children who had access to ECMO. These findings may help target areas for the development of new ECMO programs.
Commedia Dell’Arte - Serious Funny Business, Caleb Dransfield
Commedia Dell’Arte - Serious Funny Business, Caleb Dransfield
Course Materials
[From Introduction]
Picture this. It’s the year 1570. You fi nd yourself in Venice for the fi rst time and you are delighted by the unique culture around you. It’s a city built on the water, streets are replaced by canals. St Mark’s Basilica, the Doge’s palace, and the piazza do not disappoint. The Rialto is a hive of markets and vendors. As you wander the city you encounter something you haven’t seen before. A wooden stage erected, backed by a simple cloth. Onstage, actors in masks are leaping about and speaking to each other animatedly. Even with your limited …
Poetry Personified, Joseph Midolo
Poetry Personified, Joseph Midolo
Course Materials
[From Introduction]
This chapter introduces several important elements of poetry, including figurative language, sound devices, Mood & Tone, theme, and common poetic forms. Throughout the chapter, readers will examine examples of poems and literary devices while learning how poets use language to shape meaning and emotion. Students will also practice identifying poetic techniques and analyzing how these elements work together within a text.
Check Before You Trust: Teaching K–12 Students To Evaluate Digital Information, Elexia Hertel
Check Before You Trust: Teaching K–12 Students To Evaluate Digital Information, Elexia Hertel
Resources for Educators
[First paragraph]
Students in K–12 schools encounter digital information every day, but they are not always prepared to decide whether that information is credible, useful, biased, incomplete, or misleading. This chapter is written specifically for K–12 school library and classroom instruction, not for academic library users or college-level research instruction. Its primary audience is upper elementary, middle school, and early high school learners who are beginning to conduct research, cite sources, compare online information, and participate in digital life.
Investigating And Re-Imagining Contemporary Religious Leadership, Amy Lawton, Feyza Akova
Investigating And Re-Imagining Contemporary Religious Leadership, Amy Lawton, Feyza Akova
Sociology Faculty Research and Scholarship
Sociologists, anthropologists, cognitive scientists, and others have shown that religion is a feature of life in every known human society (Bellah 2011). While the cultural contexts, organizing principles, and values of each religion differ greatly – so much so that “religion” is a problematic universal category (Asad 1993) – many religions do share certain characteristics. One of those characteristics – shared among most social groups regardless of their purpose – is leadership, variously defined. Spiritual and religious groups, gatherings, and collectives have specific individuals that they turn to for wisdom, spiritual or moral guidance, fostering community, and/or ritual facilitation. We …
Risk Of Fracture Following Androgen Receptor Pathway Inhibitors In Men With Advanced Prostate Cancer, Grace Lu-Yao, Nikita Nikita, Scott W. Keith, Krupa Gandhi, Amy L. Shaver, Swapnil Sharma, Christina Steinbock-Malfer, Hushan Yang, Christopher Yang, Kevin K. Zarrabi, Stephen J. Freedland, William K. Kelly
Risk Of Fracture Following Androgen Receptor Pathway Inhibitors In Men With Advanced Prostate Cancer, Grace Lu-Yao, Nikita Nikita, Scott W. Keith, Krupa Gandhi, Amy L. Shaver, Swapnil Sharma, Christina Steinbock-Malfer, Hushan Yang, Christopher Yang, Kevin K. Zarrabi, Stephen J. Freedland, William K. Kelly
Kimmel Cancer Center Faculty Papers
BACKGROUND: This population-based study aimed to quantify fracture risk after androgen receptor pathway inhibitors in advanced prostate cancer patients by preexisting health conditions.
METHODS: Patients were identified from the Surveillance, Epidemiology, and End Results-Medicare files who received abiraterone acetate with prednisone or enzalutamide between January 1, 2013, and December 31, 2020. Health and fracture history were based on claims 1 year before androgen receptor pathway inhibitor with follow-up through December 31, 2020. The main outcome of the study was the cumulative fracture risk after first date of androgen receptor pathway inhibitor. Fine and Gray subdistribution hazard model was used to …
Subcutaneous Nodules On The Elbows Of A Teenager, Arman Haveric, Jayci G. Rhein, Jason B. Lee, Shayan Waseh, Sylvia Hsu, Afton R. Metkowski
Subcutaneous Nodules On The Elbows Of A Teenager, Arman Haveric, Jayci G. Rhein, Jason B. Lee, Shayan Waseh, Sylvia Hsu, Afton R. Metkowski
Department of Dermatology and Cutaneous Biology Faculty Papers
No abstract provided.
Current State And Needs Of Clinical Laboratories In Latin America: A Cross-Country Assessment., Alejandro R. Molinelli, Elizabeth L. Palavecino, José C. Jara-Aguirre, Kerry Cosby, Allison Targowski, Barbara Goldsmith, Rosa Sierra-Amor, Juan D. García, Alicia Algeciras-Schimnich, Eugenio H. Zabaleta, Veronica I. Luzzi, Jessica M. Colón-Franco
Current State And Needs Of Clinical Laboratories In Latin America: A Cross-Country Assessment., Alejandro R. Molinelli, Elizabeth L. Palavecino, José C. Jara-Aguirre, Kerry Cosby, Allison Targowski, Barbara Goldsmith, Rosa Sierra-Amor, Juan D. García, Alicia Algeciras-Schimnich, Eugenio H. Zabaleta, Veronica I. Luzzi, Jessica M. Colón-Franco
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
The Association for Diagnostics & Laboratory Medicine (ADLM) aims to improve health by providing education to laboratory scientists worldwide. Different regions of the world face unique challenges shaped by their national and regional contexts. However, the needs of clinical laboratories worldwide remain largely understudied. To address this gap, we conducted a comprehensive needs assessment survey among laboratory professionals in the Latin American region. The survey was distributed to over 2708 individuals across Latin American countries and yielded 148 responses. Most respondents were from urban areas (74%) and worked in private hospital laboratories (45%), with microbiology (25%) and chemistry (23%) identified …
Activity Transition Graph Generation: How Far Are We?, Jiakun Liu, Peixin Zhang, Han Hu, Yonghui Liu, Wei Minn, Ferdian Thung, Shahar Maoz, Eran Toch, Debin Gao, David Lo
Activity Transition Graph Generation: How Far Are We?, Jiakun Liu, Peixin Zhang, Han Hu, Yonghui Liu, Wei Minn, Ferdian Thung, Shahar Maoz, Eran Toch, Debin Gao, David Lo
Research Collection School Of Computing and Information Systems
Android applications (i.e., apps) are indispensable nowadays and are getting bigger and bigger with an increasing number offunctionalities. To understand how to access functionalities in an app, prior studies proposed tools to model the transitionsbetween functionalities with the activity transition graph (ATG). ATG is an important data structure and has been used forvarious Android app analyses, including app design, understanding, and testing. However, there is no benchmarking work onATG generation. It is still unclear whether the transitions identified by tools are correct and how many transitions are missed.To fill this gap, we manually identified all transitions in 98 applications to …
Operationalizing Ethics For Ai Agents: How Developers Encode Values Into Repository Context Files, Christoph Treude, Sebastian Baltes, Marc Cheong
Operationalizing Ethics For Ai Agents: How Developers Encode Values Into Repository Context Files, Christoph Treude, Sebastian Baltes, Marc Cheong
Research Collection School Of Computing and Information Systems
As AI coding agents become embedded in software development workflows, developers are beginning to operationalize ethical principles by encoding behavioral rules into repository-level context files for AI agents, such as AGENTS.md files. Rather than examining the ethics of AI agents in the abstract, this vision paper investigates how ethics and values are already being translated for AI agents into actionable instructions that shape agent behavior. Through a preliminary investigation, we find that developers are already embedding guidance related to fairness, accessibility, sustainability, tone, and privacy. These artifacts function as a developer-authored governance layer, translating abstract principles into situated, natural-language directives …
Effectiveness Of Vocational Therapy On Psychotic Symptoms Of Patients With Schizophrenia, Iman Ahmed Jumaa, Naamah Shlaibah Humaidi
Effectiveness Of Vocational Therapy On Psychotic Symptoms Of Patients With Schizophrenia, Iman Ahmed Jumaa, Naamah Shlaibah Humaidi
Iraqi Postgraduate Medical Journal
AbstractBackground: Schizophrenia is a severe mental disorder often resulting in significant functional impairment. While antipsychotic medications are the cornerstone of treatment, complementary therapies are needed to address residual symptoms and improve functional outcomes.Aims and Objectives: This study aimed to evaluate the effect of adding a structured vocational therapy program to standard drug therapy in patients with schizophrenia.Materials and Methods: A prospective was conducted with 100 inpatients at Al-Rashad Hospital. Participants were divided into two cohorts: an intervention cohort (n=50) that received vocational therapy plus drug therapy and a control cohort (n=50) that received drug therapy alone. The Positive and Negative …
The Role Of Apparent Diffusion Coefficient Value Measurement In The Differentiation Of Ischemic Stroke From Multiple Sclerosis In The Brain, Jenan Mohammed Khalid, Amer Murad Gebur
The Role Of Apparent Diffusion Coefficient Value Measurement In The Differentiation Of Ischemic Stroke From Multiple Sclerosis In The Brain, Jenan Mohammed Khalid, Amer Murad Gebur
Iraqi Postgraduate Medical Journal
Differentiating acute ischemic stroke from active multiple sclerosis (MS) plaques using conventional MRI can be challenging due to overlapping radiological features. The Apparent Diffusion Coefficient (ADC) provides a quantitative measure of water diffusion, potentially offering a solution to this diagnostic dilemma. This study aims to evaluate the role of ADC value measurements in distinguishing between acute ischemic stroke and acute demyelinating MS lesions. This cross-sectional study was conducted at a tertiary care center in Iraq from November 2024 to July 2025. All participants underwent a standardized brain MRI protocol on a 1.5-T scanner. ADC values were measured by manually placing …
Congenital Heart Disease In Infants Of Diabetic Mothers (Pediatrics Hospital Based Study), Esraa Ali Mathboob Mahdi, Basil M. Hanudi
Congenital Heart Disease In Infants Of Diabetic Mothers (Pediatrics Hospital Based Study), Esraa Ali Mathboob Mahdi, Basil M. Hanudi
Iraqi Postgraduate Medical Journal
Background: Infants born to diabetic mothers are at elevated risk for neonatal complications, including metabolic, hematologic, respiratory, cardiac, and neurological disorders. Notably, insulin-dependent diabetes increases the likelihood of congenital heart diseases (CHDs). Aim: This study aimed to determine the incidence and associated factors of cardiac complications among neonates born to diabetic mothers and to identify the prevalent patterns of congenital heart defects in this population. Methods: An analytical cross-sectional study was conducted over a 10-month period (July 1, 2020 to April 30, 2021) at the Neonatal Care Unit of Child’s Central Teaching Hospital. The study included 100 neonates admitted within …
Association Between Cesarean Scar Niche Characteristics And Menstrual Irregularities: A Cross-Sectional Study, Ridab Ali Saeed, Ahmed R. Shaker
Association Between Cesarean Scar Niche Characteristics And Menstrual Irregularities: A Cross-Sectional Study, Ridab Ali Saeed, Ahmed R. Shaker
Iraqi Postgraduate Medical Journal
ABSTRACT:Background: Cesarean section is a prevalent obstetric procedure with potential complications, including the formation of uterine niches or isthmoceles. These defects are associated with irregular menstrual cycles and adverse gynecological outcomes.Aim of the Study: To evaluate the association between cesarean scar niches and menstrual irregularities, and examine whether niche size and myometerial thickness are linked to menstrual irregularities.Patients and Methods: This cross-sectional observational study included 200 women with a history of cesarean section. Participants were divided into regular and irregular menstrual cycle groups and further categorized by the presence or absence of uterine niches. Clinical and demographic data were collected, …
Evaluating The Usefulness Of 24-Hour Video Eeg Monitoring In Dr. Sa’Ad Alwitry’S Hospital, Baghdad, Iraq, Ebtehal Dhiyaa, Akram Mohammad Al-Mahdawi, Muataz Fairooz Abd
Evaluating The Usefulness Of 24-Hour Video Eeg Monitoring In Dr. Sa’Ad Alwitry’S Hospital, Baghdad, Iraq, Ebtehal Dhiyaa, Akram Mohammad Al-Mahdawi, Muataz Fairooz Abd
Iraqi Postgraduate Medical Journal
Background: Video electroencephalography (VEEG) monitoring, which combines EEG with synchronized video recording, is a valuable but resource-intensive tool for evaluating seizure disorders. While its role in diagnosis and classification is established, its specific impact on altering provisional diagnoses and guiding treatment remains underexplored.Objective: To assess the diagnostic utility of 24-hour inpatient VEEG monitoring in confirming or modifying provisional diagnoses and reducing misdiagnosis in patients with paroxysmal events.Methods: A retrospective analysis was conducted on 192 patients who underwent VEEG monitoring at Dr. Saad Alwitry Hospital between January and December 2018. Patient records were reviewed to assess the impact of VEEG on …
Clinical And Laboratory Profile Of Pediatric Covid-19 Cases: A Retrospective Cross-Sectional Study At The Children Welfare Teaching Hospital, Baghdad, Oras Abd Al-Rahman Mankhi, Hassanien Habeeb Ghali
Clinical And Laboratory Profile Of Pediatric Covid-19 Cases: A Retrospective Cross-Sectional Study At The Children Welfare Teaching Hospital, Baghdad, Oras Abd Al-Rahman Mankhi, Hassanien Habeeb Ghali
Iraqi Postgraduate Medical Journal
Background: Coronavirus disease 2019 (COVID-19) continues to pose a global health challenge. Although children are generally less severely affected than adults, severe outcomes and mortality continue to be reported, particularly in low-resource settings. paediatric cases may present with a wide spectrum of clinical manifestations. Understanding the clinical and laboratory characteristics of pediatric COVID-19 in Iraq is essential for improving diagnosis, management, and outcomes.Objective: To describe the demographic, clinical, laboratory and radiological characteristics of pediatric COVID-19 patients admitted to the Children Welfare Teaching Hospital (CWTH), Baghdad, and to identify factors associated with disease severity.Methods: A retrospective cross-sectional study was conducted on …
Immunohistochemical Expression Of Estrogen Receptor In Papillary Thyroid Carcinoma With Lymph Node Metastasis, Furqan J. Albderi, Kaswer M. Altoriahi
Immunohistochemical Expression Of Estrogen Receptor In Papillary Thyroid Carcinoma With Lymph Node Metastasis, Furqan J. Albderi, Kaswer M. Altoriahi
Iraqi Postgraduate Medical Journal
Background: Papillary thyroid carcinoma (PTC) is the most common well-differentiated thyroid malignancy. The female predominance of PTC suggests a potential role for estrogen signaling, mediated through estrogen receptors (ER), in thyroid carcinogenesis and progression.Objective: This study aimed to evaluate estrogen receptor protein expression in papillary thyroid carcinoma with lymph node metastasis and to analyze its association with clinicopathological parameters.Methods: A retrospective study was conducted on 50 formalin-fixed, paraffin-embedded thyroid and corresponding lymph node tissue specimens from Iraqi patients with PTC and lymph node metastasis. ER expression was assessed by immunohistochemistry. Associations between ER expression and clinicopathological variables were analyzed using …
Evaluation Of Peripheral Nerves In Patients With Acromegaly By Electrodiagnostic Study, Taiseer Saad Musa, Farqad Bader Hamdan, Abbas Mahdi Rahmah
Evaluation Of Peripheral Nerves In Patients With Acromegaly By Electrodiagnostic Study, Taiseer Saad Musa, Farqad Bader Hamdan, Abbas Mahdi Rahmah
Iraqi Postgraduate Medical Journal
Background: Acromegaly is a rare multisystem disorder caused by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), typically from a pituitary somatotroph adenoma. Neurological complications, particularly peripheral neuropathies, are common but under-investigated.Objectives: To evaluate peripheral nerve involvement in Iraqi patients with acromegaly and assess the impact of IGF-1 levels, disease duration, adenoma size, and other clinical variables on nerve function.Methods: A cross-sectional study included 41 acromegalic patients (≥25 years) who underwent detailed neurophysiological testing. Patients were classified as metabolically controlled or uncontrolled based on IGF-1 levels.Results: IGF-1 and GH levels were significantly lower in the controlled group (p<0.001), while other clinical variables showed no significant differences. Neurophysiological findings revealed significantly reduced sensory and motor amplitudes, prolonged latencies, and slower conduction velocities in the uncontrolled group. IGF-1 levels correlated positively with sensory and motor latencies and negatively with conduction velocities and CMAP amplitudes. Larger adenoma size and presence of diabetes were also associated with worse nerve parameters. Deep X-ray therapy and surgical excision showed beneficial associations with median nerve conduction velocity.Conclusion: Peripheral nerve dysfunction, including carpal tunnel syndrome and polyneuropathy, is more severe in metabolically uncontrolled acromegaly. Macroadenomas and poor biochemical control are linked with worse neurophysiological outcomes.
Family Medicine In Iraq: Bridging The Gap Between Training And Practice For Health System Reform, Eman A. Al-Kaseer
Family Medicine In Iraq: Bridging The Gap Between Training And Practice For Health System Reform, Eman A. Al-Kaseer
Iraqi Postgraduate Medical Journal
No abstract provided.
Adaptive Solar Energy Collection Fenestration Systems; Measured Performance On Test Cell Under Real Weather Conditions., Noel O’Neill
Adaptive Solar Energy Collection Fenestration Systems; Measured Performance On Test Cell Under Real Weather Conditions., Noel O’Neill
Doctoral
Buildings account for a significant share of global energy use, and improving façade performance is critical to achieving nearly zero-energy building targets. This research addresses the challenge of integrating multiple adaptive functions into a single façade system to reduce heat loss, harness solar energy, and provide dynamic environmental control. The aim was to design, construct, and evaluate an adaptive Multi-Functional Façade (MFF) that integrates vacuum glazing, switchable opacity glazing, and a ventilated cavity with active airflow control to provide façade insulation, heated fresh air, recirculated air, or exhaust ventilation.
A Solar Thermal Test Cell (STTC) designed to Passive House standard, …
Monitoring And Short-Term Forecasting Of Atmospheric Air Pollutants Using Deep Neural Networks, Prasanjit Dey
Monitoring And Short-Term Forecasting Of Atmospheric Air Pollutants Using Deep Neural Networks, Prasanjit Dey
Dissertations
Accurate forecasting of near-surface atmospheric air pollutants such as PM2.5, NO2, SO2, CO, and O3 remains a critical scientific and societal challenge. This difficulty arises from several factors, including nonlinear pollutant dynamics, sparse ground monitoring net works, heterogeneous satellite observations, and strong cross-pollutant interdependencies. Substantial advances have been achieved in temporal deep learning, probabilistic modeling, satellite-based estimation, physics-informed methods, and foundation models. However, these paradigms have largely evolved in isolation. As a result, existing systems are often station-dependent or pollutant-specific and optimized for a single forecasting task. This limits their robustness and generalizability across regions and heterogeneous data regimes.
This …
Spatially Dissecting Drivers Of Inter-And Intra-Tumoral Heterogeneity In Kenyan Breast Cancer, Mustapha Abubakar, Shahin Sayed, Hela Koka, Scott Lawrence, Karun Mutreja, Xing Hua, Petra Lenz, Samuel Anyaso-Samuel, Rosemary Kamau, Beryl Ooro
Spatially Dissecting Drivers Of Inter-And Intra-Tumoral Heterogeneity In Kenyan Breast Cancer, Mustapha Abubakar, Shahin Sayed, Hela Koka, Scott Lawrence, Karun Mutreja, Xing Hua, Petra Lenz, Samuel Anyaso-Samuel, Rosemary Kamau, Beryl Ooro
Pathology, East Africa
Despite growing evidence on the impact of intra-tumoral heterogeneity (ITH) in breast cancer (BC), its biological drivers and clinically relevant mitigation strategies remain poorly characterized, particularly in low-resource settings where spatial profiling is rarely applied. To address this gap, we conducted a comprehensive, multiplatform spatial profiling study of BC in a Kenyan population. Using the NanoString GeoMx™ Digital Spatial Profiler, we quantified 44 protein markers across 707 spatially defined, PanCK-segmented Areas of Illumination (AOIs) from 31 tumors. All tumors exhibited measurable ITH, with one-third showing marked heterogeneity. Sixteen patients exhibited two or more intrinsic subtypes within their tumors, three of …
Mexico Consensus Economic Forecast Volume 29, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton
Mexico Consensus Economic Forecast Volume 29, Number 2, Thomas M. Fullerton Jr., Steven L. Fullerton
Border Region Modeling Project
No abstract provided.