Digital Commons Network^™

Exploring Transgender And Gender Expansive Youth's Experiences With Vicarious Minority Stress, Erin T. Pereida

Graduate Doctoral Dissertations

In the United States (U.S.), transgender and gender expansive (TGE) youth experience elevated rates of depressive symptoms, self-harm behaviors, and suicidality compared to cisgender peers. Mental health professionals and researchers often use the gender minority stress model to explain these elevated rates, positing that stressors related to minority identity experienced above and beyond normative daily stress contribute to adverse mental health outcomes. One emerging component of the model requiring further investigation is vicarious minority stress; stress experienced indirectly through witnessing or learning of gender minority stressors affecting other TGD individuals or the community more broadly. The present study explored this …

The Role Of Androgen Receptor And B2/Alu Sine Rna Interaction In Hippocampal Dendritic Development, Troy A. Richter

Graduate Doctoral Dissertations

Once dismissed as “junk”, transposable elements have recently gained recognition for their regulatory roles, especially in the brain. During development, circulating androgens promote proper morphological development of hippocampal neurons. We and others have shown that murine B2 SINE RNA is a regulator in the rodent hippocampus. It is unknown, however, if B2 is necessary for the proper development of hippocampal neurons. This dissertation investigates the role of murine B2 in the development of primary hippocampal neurons in combination with androgen treatment. We first examined the role of ALU SINE and androgen receptor in a prostate cancer cell model and found …

Resistance Training Load-Volume Effects On Maximal Strength, Isometric Force-Time Characteristics, And Force-Velocity Relationships, Chieh-Hsin Yu

Electronic Theses and Dissertations

The investigations concerned the effects of resistance training programs with different load–volume configurations on multiple strength characteristics, including maximal strength, isometric force–time properties, and force–velocity (F–v) relationships. Following a review of training interventions across these variables, two ecologically valid resistance training prescriptions were compared: high-load, low-volume (HLLV) and moderate-load, moderate-volume (MLMV). Fourteen recreationally trained participants were grouped into either HLLV (three sets of two repetitions at ≥ 80% 1RM) or MLMV (three sets of ten repetitions at 60–80% 1RM), incorporated into the main lifts of a 4-week program. Strength was assessed using back squat one-repetition maximum …

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …

Β-Aminopropionitrile-Induced Thoracic Aortopathy Is Refractory To Cilostazol And Sildenafil In Mice, Samuel C. Tyagi, Sohei Ito, Jacob C. Hubbuch, Michael K. Franklin, Deborah A. Howatt, Hong S. Lu, Alan Daugherty, Hisashi Sawada

Surgery Faculty Publications

Thoracic aortopathies are life-threatening diseases including aneurysm, dissection, and rupture. Cilostazol, a phosphodiesterase (PDE) 3 inhibitor, and sildenafil, a PDE5 inhibitor, have been used clinically for peripheral arterial disease and erectile dysfunction or pulmonary hypertension, respectively. Recent studies report their effects on abdominal aortic aneurysm formation. However, their impacts on thoracic aortopathy remain unknown. In this study, we investigated whether cilostazol and sildenafil affect thoracic aortopathy induced by β-aminopropionitrile (BAPN) administration in mice. Bulk RNA sequencing analysis revealed that BAPN administration upregulated Pde3a transcription in the ascending aorta and Pde5a in both ascending and descending regions before thoracic aortopathy formation. …

Artificial Intelligence And The Law: A Discussion And Selections From The Collection, Wolf Law Library, William & Mary Law School

Library Book Displays

On display in the Wolf Law Library August 2025 - January 2026.

Molecular And Clinical Insights Into Role Of Gper In Hepatocellular Carcinoma (Hcc), Hossain Ahmed

Theses and Dissertations

Metabolic dysfunction–associated steatotic liver disease (MASLD), encompassing stages from steatosis (MASLD) to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC), is the most prevalent chronic liver disease worldwide, yet molecular markers of progression remain limited. The G protein–coupled estrogen receptor (GPER), a non-genomic estrogen receptor with metabolic and anti-inflammatory roles, emerges as a candidate regulator in hepatic pathophysiology. In this Dissertation thesis, we have delineated for the first time clinicopathological assessment of liver biopsies across MASLD stages revealing a robust inverse correlation between GPER expression and disease severity. Higher GPER levels in early MASLD associated with favorable metabolic and biochemical profiles, …

Enigmatic Roles Of Complement Anaphylatoxin Signaling In Health And Disease, Anthony Shadid, Kathryn D Hok, Aleksey Y Domozhirov, Tingting Weng-Mills, Marie-Françoise Doursout, Nirmal K Banda, Marcos I Restrepo, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Complement anaphylatoxins C3a and C5a are potent immunomodulators whose impact extends well beyond their traditional roles in innate immunity. Acting through G protein-coupled receptors C3aR, C5aR1, and C5aR2, these peptides take part in coordinating immune cell recruitment, vascular tone, and tissue remodeling. Yet their functions are deeply context-dependent: while they play essential roles in microbial clearance and immune coordination, their overactivation contributes to immunopathology in a wide range of diseases. The anaphylatoxins play key roles in early pathogen containment but can also drive cytokine storm and tissue damage, as in coronavirus disease 2019 (COVID-19) and bacterial sepsis. In autoimmune conditions, …

From The Battlefield To The Archive: Tracing Testimony In Holocaust Memory, Tiana M. Taliep

War, Diplomacy, and Society (MA) Theses

This thesis portfolio examines the evolving role of testimony in shaping public memory of World War II and the Holocaust. As the last generation of eyewitnesses passes, societies increasingly rely on preserved, mediated forms of testimony to understand and remember traumatic pasts. Testimony, whether handwritten, oral, visual, or digital, is not a neutral historical record but an interpretive act shaped by cultural, political, and technological forces. This portfolio argues that testimony functions as evidence and expression: it transmits trauma across generations while simultaneously reflecting the changing frameworks through which war and genocide are remembered.

The portfolio explores testimony in personal, …

Investigating The Impact Of Instructor Presence In Lecture Videos On Learning Experiences: A Comparative Study, Keone K. Fuqua

Graduate Theses and Dissertations (2019 - present)

As online learning continues to grow, understanding how instructional design features influence student experience becomes increasingly important. One critical feature in video-based instruction in instructor presence - the degree to which the instructor is visually or vocally present in the lesson. The purpose of this study was to investigate how varying levels of instructor presence in asynchronous lector videos affect students' perceived relatedness, satisfaction, engagement, content retention, and cognitive effort.

A mixed methods experimental design was employed, with 93 undergraduate and graduate students from a public university randomly assigned to one of three video lesson conditions: Full Presence (instructor visible …

Connecting The Dots: Teacher Self-Efficacy, Student-Teacher Relationships, And Behavior Management In Early Childhood, Courtney Lewis

Graduate Theses and Dissertations (2019 - present)

This study was designed to explore the relationships between teacher self-efficacy, student-teacher relationships, and use of behavior management strategies in early childhood education. Previous research suggests that effective early childhood education improves a child’s academic and social outcomes. This study sought to explore factors contributing to teacher effectiveness in preschool teachers. The hypotheses were that (1) teacher self-efficacy will directly affect student teacher relationships, (2) that studentteacher relationships will directly affect teacher’s frequency, confidence, and success of their behavior management strategies, and (3) that student-teacher relationships will act as a mediating variable between teacher self-efficacy and the frequency, confidence, and …

Out-Of-Band Anomaly Detection For Real Time Operating Systems, Jeffrey K. Holifield

Graduate Theses and Dissertations (2019 - present)

Real Time Operating Systems (RTOS) are increasing present throughout the industrial, business, defense, and healthcare spaces. These lightweight and efficient operating systems are designed to run on embedded, resource constrained devices, often within cyber-physical systems (CPS). A defining characteristic ofRTOSs is that they are deterministic. Tasks are scheduled to run on fixed timelines within guaranteed execution windows. In Industry 4.0 applications for example, sensors must receive and process inputs within a fixed schedule to ensure products are properly manufactured. This requires guaranteed service at fixed time periods. To accomplish this, RTOSs must conform to worst case execution times (WCETs) as …

Yizhi Sun: Profile Of The Newest Chbc Faculty Member., Danna Jaimes-Fajardo, Jeremy J. Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

Presents the research profile of Yizhi Sun, Assistant Professor, Chemistry and Biochemistry department. It highlights his research interests, education, and impact of his research.

The Power Of Social Capital For First-Generation College Students, Inez M. Gonzalez Perezchica

Journal of College Access

First-generation college students (FGCS) face unique challenges in achieving career success, challenges which stem from limited access to social capital. Social capital refers to the value derived from access to social structures, which serve as resources that enable individuals to pursue and attain their interests (Coleman, 1988). Enhancing mentoring for FGCS requires an understanding of how social capital facilitates success and upward mobility. FGCS face information gaps that can hinder their ability to navigate college bureaucracy, advance their careers, and beyond. To address this information gap, FGCS can seek advisors and mentors, or institutional agents, who can provide critical insights …

Complete Issue, Claudia Martinez, Lorenzo M. Sianez Jr

Journal of College Access

No abstract provided.

Cultivating Connections: Toward A Framework For Equity In Social Capital Development In College And Career Pathways, Samantha L. Perez

Journal of College Access

The attention on college and career pathways over the last decade has revitalized interest in key activities like early career exploration, work-based learning, and labor market alignment of career and technical education. One essential element of this work, and perhaps among the most critical, has not received as much attention. Research shows that social capital—the relationships and networks an individual has and their ability to build, leverage, and mobilize them— is often how people get access to new information and educational and career opportunities; however, it is not something that most school systems have made an explicit priority for preparing …

Effects Of Emotional Intelligence In Enhancing Team Collaboration And Conflict Resolution In Agile Project Management, Shaikh Muhammad Sinan

Harrisburg University Dissertations and Theses

In this study, I explored the use of emotional intelligence (EI) in enhancing team collaboration and conflict resolution within agile project management environments. Though agile methodologies have gained more popularity, most projects still suffer from interpersonal conflicts and communication failures that detract from project performance. Though the literature is particular to the dynamics of agile project management, little is known about the emotional and interpersonal dynamics that influence team effectiveness. I examined how EI skills such as self-awareness, self-regulation, empathy, and social skills influence team dynamics and project success. Guided by Daniel Goleman's Emotional Intelligence Framework, in this qualitative study, …

Factors Influencing Healthcare Cybersecurity Effectiveness: An Empirical Investigation, Machuria Mallette Johnson

All Dissertations

The healthcare sector faces escalating cybersecurity risks due to its reliance on electronic health records, legacy systems, medical devices, and health information exchanges. These interconnected technologies expand attack surfaces and create vulnerabilities that threaten patient data, operational continuity, and public trust. These challenges cause many healthcare organizations to struggle to implement effective cybersecurity strategies.

The purpose of this study was to investigate the factors that influence healthcare cybersecurity effectiveness by integrating Institutional Theory, Dynamic Capabilities Theory, Top Management Support, and IT Infrastructure Quality. A survey was administered to healthcare IT, cybersecurity, and executive professionals across the United States. The final …

Effective Transformer Networks For Undersampled Magnetic Resonance Image Reconstruction, Tahsin Rahman

Open Access Theses & Dissertations

The proliferation of data-driven tools for solving problems in every possible domain, coupled with rapid advances in computing technology, has led to an arms race of AI development and application research in industry and academia. One field of research that stands to gain immeasurably from this revolution is medical imaging. It is a critical part of modern diagnostics, and advancements in this area can directly benefit the average person by making healthcare more accessible, accurate, and affordable. Breakthroughs in mainstream image processing and computer vision have long fueled development in medical imaging, and it is now common to see cutting …

Experimental Investigation Of Photovoltaic Soiling Losses And Aerosol Absorption And Scattering Related To Dust In The Chihuahuan Desert Region, German Rodriguez Ortiz

Open Access Theses & Dissertations

This dissertation explores the interaction between mineral dust and solar radiation in the Chihuahuan Desert, one of the dustiest areas in North America. I focused on two main aspects: (1) the characterization of atmospheric aerosol optical properties during dust events, and (2) the effects of dust deposition (soiling) on the performance of photovoltaic (PV) modules. I characterized the intrinsic optical properties of aerosols in El Paso, Texas during the peak of the 2021 dust season. Ground-level, high-resolution optical and meteorological data were collected at the Black and Brown Carbon (BC^2) study site, whereas particulate matter and additional meteorological parameters were …

A Multi-Modal Method For Synthetic Data Generation In Social Network Analysis, Hortencia Josefina Hernandez

Open Access Theses & Dissertations

Social network analysis (SNA) research is often rife with data collection pitfalls, frequently leading to incomplete and missing data. With the growing use of SNA-based research, researchers must address the challenge of missing data and synthetic data generation in these settings. Missing data occurs due to longitudinal non-response or lack of response to sensitive or difficult-to-answer questions. Synthetic data generation in SNA settings addresses the lack of representation that is often present in large-scale SNA studies. This dissertation investigates synthetic data generation methods to address these challenges and develops a novel algorithm that leverages information from multi-modal data, e.g., databases …

Improving Glycemic Control Mechanisms By Electrical Muscle Stimulation, Jehu Narh Apaflo

Open Access Theses & Dissertations

Introduction: Neuromuscular electrical stimulation (NMES) has emerged as a promising intervention for improving metabolic health in sedentary individuals with overweight or obesity. Its capacity to induce muscle contraction without voluntary movement presents a viable alternative to traditional exercise, especially in mobility-limited populations. NMES may serve as a non-invasive alternative to traditional exercise, especially in high-risk populations who face elevated type 2 diabetes incidence linked to hyperglycemia, obesity, and inactivity. This study investigated the impact of NMES on glycemic control and metabolic health in a sedentary, predominantly Hispanic, overweight or obese population. Methods: This study examined the acute and long-term effects …

Digital Twin For Real-Time Monitoring And Control Of Conveyor Systems Using Flexsim, Ai And Plc Integration, Jose Francisco Arvizu Astorga

Open Access Theses & Dissertations

Modern manufacturing is making significant advancements by innovating and automating most processes. However, a major challenge remains: systems are constantly evolving and becoming more complex to analyze. Fortunately, a powerful tool can help, Digital Twin (DT) technology. This technology enables the analysis and optimization of processes like never before. A Digital Twin is a real-time virtual model of a physical system that continuously up dates with live data. One of its greatest features is the ability to create infinite scenarios, allowing hundreds of configurations to be tested virtually, risk-free, and without making any real-world changes that could disrupt ongoing operations. …

Thermal Inkjet Bioprinting Of Human Fibroblasts Into Stem Cell Environment Leads To Stem-Like Gene And Protein Expression And Changes In Hippo Pathway Effectors Yap/Taz, Patricia Ablanedo Morales

Open Access Theses & Dissertations

Thermal inkjet bioprinting (TIB) has emerged as a powerful tool with many potential applications, such as organ regeneration, drug testing, and cell differentiation, among others. Despite the forces and stress that cells are subjected to during the printing process, there is little research that investigates in detail the combined effects of the TIB process and the surrounding environment on cells. Furthermore, a cell's biological environment greatly influences its behavior. Therefore, understanding the effects of bioprinting on cells in a particular environment at a genetic level can provide clues regarding changes in cell characteristics. Bioprinting could potentially be used as a …

Learning English On The Border: Identities, Investment, And Imagined Futures In El Paso, Texas, Jennifer Lyn Mansour

Open Access Theses & Dissertations

This qualitative study explores how adult English language learners living along the U.S.-Mexico border in El Paso, Texas experience language learning, identity formation, and social positioning within a bilingual community. Drawing on Norton's (1995, 2013) theoretical frameworks of identity, investment, and imagined communities, the research investigates three central questions: (1) How does the relationship between English learners and the social world of a bilingual community on the U.S.-Mexico border impact their ideas about their possibilities for the future? (2) How does the use of English construct worlds that are different from those constructed in their first languages, and do learners …

Study On Self-Interaction Errors In Molecular Properties And Magnetic Behaviour Of 2d Materials Under External Stimuli Using Density Functional Theory, Prakash Mishra

Open Access Theses & Dissertations

Density Functional Theory (DFT) has established itself as a practical and versatile method for efficiently studying the properties of materials of solids and molecules. Despite being exact in principle, in practice, DFT calculations rely on an approximation for the exchange-correlation energy functional of the electron density. This results in an erroneous interaction of the electron with itself, known as the self-interaction error (SIE). It arises from the fact that the exchange self-interaction does not exactly cancel out the Coulomb self-interaction. Due to this error, the approximate one-electron potential decays exponentially in the asymptotic region rather than exhibiting the correct ?1 …

Application Of Distributed Fiber Optic Sensing (Dfos) For Monitoring Asphalt Pavement Strains Under Accelerated Loading Conditions, Sebastian Morales

Open Access Theses & Dissertations

This thesis presents a study on the application of Distributed Fiber Optic Sensing (DFOS) technology for detecting pavement's strain response with high spatial resolution. Using a Rayleigh-based optical frequency domain reflectometry (OFDR) system, DFOS sensors were calibrated and embedded in full-scale asphalt slabs subjected to accelerated loading using a Model Mobile Load Simulator 3 (MMLS3). Calibration of the DFOS sensors was conducted using a three-point bending flexural test with known load conditions and reference strain gauges to validate theoretical and numerical models. The results demonstrate DFOS's capability to detect pavement response under static and dynamic loading, as well as changes …

The Alchemy Of Respect In The First-Year Composition Classroom, Raphael Ivan Reyes Juarez

Open Access Theses & Dissertations

In this research, I wanted to understand how respect in the First-Year Composition classroom was understood, applied, and negotiated by undergraduate students. Also, I proposed a concept called the alchemy of respect, which describes the transformations, addition of value to students' ideas, and the refinement of their abilities in the classroom. The study relied on three theoretical approaches: virtue ethics by John Duffy, community literacy by Linda Flower, and rhetoric of respect by Tiffany Rousculp. I found important concepts in their work, such as the analysis of morals in the decisions people make, the construction of communities across differences, and …

High-Frequency Seismic Noise In Desert Environments, Alexis Hernandez

Open Access Theses & Dissertations

This study investigates the generation and modulation of ambient seismic noise in arid environments, with a focus on aeolian processes such as saltation, wind shear, and precipitation events. Using a dense array of three-component seismic nodes co-located with meteorological sensors and a novel particle transport instrument (SANTRI), high-frequency seismic signatures were examined within the Jornada Experimental Range in southern New Mexico. Time-frequency analysis reveals that wind-driven saltation events produce measurable seismic energy enhancements, particularly within the 100-300 Hz band, with clear spectral distinctions between wind-only forcing and particle-laden transport. Additionally, rainfall events were identified by elevated seismic amplitudes in the …

Characterization Of Glyt1 Expression And Glycinergic Circuits, Laura Patricia Montes

Open Access Theses & Dissertations

Glycine is one of the main inhibitory neurotransmitters in the central nervous system. Glycine is regulated by the glycine transporters 1 and 2 (GlyT1 and GlyT2, respectively) in the synaptic cleft. Both transporters participate in glycinergic inhibitory neurotransmission. Moreover, GlyT1 also participates in glutamatergic excitatory neurotransmission. GlyT2 is devoted to caudal regions of the brain and is used as a marker for glycinergic neurons. In contrast, GlyT1 is expressed across the brain in the rostrocaudal axis and is highly associated with GlyT1-positive glial cells. Data from our laboratory has identified GlyT1-positive neurons in the rodent brain. Therefore, we hypothesize that …