Digital Commons Network^™

Multicenter Span Trial Of Fasudil In Ischemic Stroke, Takahiko Imai, Andreia Lopes De Morais, Xuyan Jin, Tao Qin, Jessica Lamb, Karisma A Nagarkatti, Mu-Hsun Chen, Ligia S B Boisserand, Rakesh B Patel, Mariia Kumskova, Anjali Chauhan, Krishnan M Dhandapani, Mohammad B Khan, Pradip K Kamat, Yanrong Shi, Suyi Cao, Basavaraju G Sanganahalli, Joseph B Mandeville, Patrick D Lyden, David C Hess, Enrique C Leira, Anil K Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Raymond C Koehler, Lauren H Sansing, Márcio A Diniz, Cenk Ayata

Children’s Nutrition Research Center Staff Publications

Background: The SPAN (Stroke Preclinical Assessment Network) is a confirmatory multicenter trial network to test cerebroprotective interventions in experimental acute stroke. In a first-of-its-kind trial, SPAN tested 6 interventions in a rodent model of transient focal ischemic stroke. Here, we report the efficacy of fasudil, an isoform-nonselective rho-associated kinase inhibitor, on primary and secondary outcomes in the SPAN trial.

Methods: Fasudil was administered at 10 mg/kg intraperitoneally every 12 hours for 6 doses starting 5 minutes before reperfusion in a 60-minute endovascular filament middle cerebral artery occlusion model. The active treatment arm (n=345) was compared with the pooled intraperitoneal and …

Family-Level Factors That Influence Physical Activity Among Hispanic Adolescents At Risk For Type 2 Diabetes, Sandra Mihail, Ayleen A Hernandez, Erica G Soltero

Children’s Nutrition Research Center Staff Publications

Objective: Family-based health promotion and disease prevention strategies are recommended as best practice; however, there is limited knowledge regarding the family-level factors that influence modifiable behavior risk factors like physical activity (PA) among Latinx adolescents. This study addressed this knowledge gap by using qualitative methods to identify perceptions of family-level factors that influence PA among Hispanic youth.

Methods: We conducted semistructured, open-ended interviews with 20 Latinx adolescents (14-16 years) with obesity (body mass index ≥95th percentile) to identify their perceptions of how family influences PA. Content analysis was used to identify emergent themes, which were then compared across demographic factors, …

Behind The Trend: An Examination Of Primate Content On Tiktok, Kelsie K. Strong, Lilith A. Frakes, Jessica A. Mayhew, Chelsea J. Thompson, Caroline P. Ratliff

Anthropology Faculty Publications and Presentations

Social media platforms today are teeming with images of wildlife as pets, and studies have emerged investigating the role social media plays on the public's perception of primates and their desirability as pets. This study explores the presentation of nonhuman primates and video engagement, defined as user interactions through likes, comments, shares, and views, on the social media platform TikTok. We examined 1378 videos from 173 different TikTok content creators sharing primate videos. Most content depicted primates within a household (43.1%), indicating they are often shown in the context of being pets. This is cause for concern because the portrayal …

Formation Of Inclusive Competence Of Future Special Education Teachers, Gulbanu Ashimkhanova, Akbota Autaeva, Anar Rakhmetova, Gulmira Tussupbekova, Kanat Sadykov

Higher Learning Research Communications

Objectives: This study aims to explore the phenomenon of inclusive competence as an integral trait of today’s educators.

Methods: The scientific research involved surveying students from pedagogical universities as well as using methods of analysis and synthesis, generalization, systematization, comparison, and classification.

Results: The concept of inclusive competence is understood as the degree of skills and knowledge required to fulfil pedagogical responsibilities within an inclusive educational environment. Key elements of inclusive competence, such as cognitive, motivational, reflexive, and operational components, have been identified and have the following functions:

• · Cognitive elements enable teachers to develop a comprehensive understanding of pedagogical …

Indigenous Gut Health, Tasha Vivier Morin

Indigenous Health Student Publications

Indigenous gut health is a critical but often overlooked determinant of overall well-being. Gut health encompasses digestion, nutrient absorption, immune function, and the balance of the microbiome. Indigenous communities face unique challenges related to geography, food access, and the legacy of colonization, all of which affect dietary diversity and microbiome health. Drawing from the Health Belief Model, this project proposes a culturally responsive, education-based intervention to increase awareness of fiber-rich diets and their role in preventing chronic disease. The intervention aims to address upstream factors such as food access and health literacy, particularly among Indigenous families. Traditional diets once supported …

Digital Media In Teaching & Learning Reading Comprehension: The View Of The Efl Pre-Service Teachers In An Indonesian Higher Education, Mistang Mistang, Ruslin Ruslin, Zul Aini Rengur, Hijrah Syam, Siti Wirana

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The rapid advancement of digital technology has transformed the dynamics of reading comprehension instruction, particularly in the context of English as a Foreign Language (EFL) learning. This study aims to explore the perspectives of EFL pre-service teachers regarding the teaching and learning of reading comprehension in digital-based learning environments. Additionally, the research seeks to understand the challenges these preservice teachers face in teaching reading skills and to investigate the effectiveness of current digital media in enhancing EFL pre-service teachers’ reading comprehension abilities. Employing a mixed-methods approach, quantitative data were collected through online questionnaires distributed to 26 respondents, while qualitative data …

A Tale Of Two Toxicants: Investigating The Interaction Between Hexavalent Chromium And Perfluorooctane Sulfonic Acid., Morgan Elizabeth Delnicki

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] and per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of major public health concern. Despite commonly being found together in contaminated drinking water, no studies have considered the concomitant health effects of Cr(VI) and PFAS, specifically perfluorooctane sulfonic acid (PFOS). In vitro studies using CHO cells assessed the cytotoxicity and genotoxicity of Cr(VI) and PFAS both individually and in combination. Intracellular and extracellular Cr levels were measured with Atomic Absorption Spectrometry. PFOS was found to exacerbate Cr(VI) induced cytotoxicity and genotoxicity. Additionally, a novel in vivo model of studying the hepatotoxicity of Cr(VI) was established. Adult Hartley …

Exploring Hexavalent Chromium Exposure And Lipid Accumulation In Liver Disease., Gabrielle Celine Griffin

Electronic Theses and Dissertations

The prevalence of MASLD has doubled over the past 20 years and continues to rise. Hexavalent chromium [Cr(VI)], a top chemical hazard in U.S. drinking water, is emerging as potential risk factor for liver disease. To study the impact of Cr(VI) and high-fat diet on MASLD, we developed an in vivo model using Sprague-Dawley rats exposed to Cr(VI) in drinking water (0, 0.05, or 0.1 mg/L) and fed normal or high-fat diet for 90 days. High-fat diet significantly increased body mass, plasma lipoproteins, cholesterol, liver injury, and hepatic triglycerides, which were exacerbated by Cr(VI) exposure. Cr(VI) alone increased hepatic chromium …

Analysis Of An Ethanol Sensitive Bmp-Nkx2.3-Fgf Signaling Pathway In Pouch Morphogenesis., Hieu Dai Le Vo

Electronic Theses and Dissertations

Craniofacial malformations lie at the heart of Fetal Alcohol Spectrum Disorders (FASD). While there is growing evidence for a genetic component to FASD, little is known of the cellular mechanisms underlying these ethanol-sensitive loci in facial development. Bone Morphogenetic Protein (Bmp) signaling pathway dependent pouch formation is a key mechanism in facial development. We have previously shown that multiple Bmp mutants are sensitized to ethanol-induced facial defects. However, ethanol does not directly impact Bmp signaling. This suggests that downstream effectors, like nkx2.3 and Fibroblast Growth Factor (Fgf) signaling, may mediate the impact of ethanol on Bmp mutants. Here, I …

Understanding The Potential Impact Of Ostracism On Lgbtq Health Disparities, Ellen D.B. Riggle

Political Science Faculty Publications

Research finds harmful impacts of ostracism on the health and well-being of the ostracized individual (as well as the ostracizer and members of the community). While often conceptualized as social (interpersonal), ostracism may originate at multiple levels of the socio-ecological system, including forms of political and institutional ostracism. The ostracism of LGBTQ people originates in cultural stigma and is reproduced and reinforced at all levels, from discriminatory laws and institutional policies (e.g., workplace, educational), to the actions of community or family members, to interactions with strangers. Ostracism, acute and chronic, creates increased risk for psychological and physical harm to LGBTQ …

Human Salivary Gland Stem/Progenitor Cells For Tissue Engineering, Sars-Cov-2 Susceptibility, And Neurointegration, Caitlynn Barrows

Dissertations and Theses (Open Access)

Salivary glands and the saliva they secrete are important for digestion, chewing, and maintaining oral health. Reduced saliva production leads to a decreased quality of life for patients experiencing hyposalivation as a result of disease or injury, thus a large effort has been dedicated to developing materials and medium to recapitulate the structure of the gland for regenerative medicine. In doing so, we have come closer to developing a more complex model to study disease. These models, however, do not yet fully recapitulate the gland. In this dissertation, we describe a new cell source that can be used to develop …

Integrating Bulk And Single-Cell Transcriptomics To Investigate Intratumor Heterogeneity, Shuai Guo

Dissertations and Theses (Open Access)

Cancers are heterogeneous mixtures of tumor and surrounding cells, where each component comprises multiple distinct sub-types and/or states. Understanding the cell-type-specific contributions is critical for advancing cancer biology, yet high-throughput expression profiles from tumor tissues only represent combined signals from all diverse cellular sources. Bulk deconvolution with single-cell/nucleus (sc/sn) RNA-seq data has emerged as a powerful approach to dissect both cellular composition and cell-type-specific expression patterns, yet the technological discrepancy across sequencing platforms limits accuracy.

To systematically evaluate the impact of platform discrepancies on bulk deconvolution, we first generated a benchmark dataset of 24 healthy retinas with paired bulk and …

Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression During Immunotherapy, Er-Yen Yen

Dissertations and Theses (Open Access)

Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral heterogeneity in influencing immune interactions. Using orthotopic clonal replica tumors, we tracked clonal dynamics in response to anti-PD1 therapy and found that while treatment had limited impact on overall tumor volume, it induced profound shifts in clonal composition. Spatial lineage analysis of treatment-naïve tumors revealed that clones with distinct immunotherapy sensitivities occupy unique tumor microenvironments, a pattern that remained stable …

Chronic Cluster Headache Is A Rare Disease: Implications For Diagnosis, Treatment And Public Health, Hsiangkuo Yuan, Jan Hoffmann, Elena Ruiz De La Torre, Michael J. Marmura, Mario F. P. Peres

Department of Jefferson Headache Center Papers and Presentations

Cluster headache (CH) is a rare and painful primary headache disorder characterized by severe unilateral pain and cranial autonomic symptoms. This perspective examines the epidemiological evidence supporting the classification of chronic cluster headache (CCH) as a rare disease, noting a prevalence of CH of approximately 124 per 100,000 individuals, with only 3.5-13.7% manifesting CCH. This prevalence meets criteria established by both the US Food and Drug Administration and European Medicines Agency for rare disease designation. The rarity of CCH creates substantial clinical and research challenges, including prolonged diagnostic delays, limited research funding and a dearth of approved treatments. The economic …

Halmos College Graduate Academic Calendar 2025-2026, Halmos College Of Arts And Sciences (Hcas)

HCAS Academic Calendars

No abstract provided.

College Students And Wearable Health Technology: A Study On Digital Health Literacy, Gavin Wright

Undergraduate Honors Thesis Collection

The market for wearable devices has seen significant growth in the last decade and is only expected to increase as the world enters a new age of health literacy known as digital health literacy. Digital health literacy, or eHealth literacy, is defined as “the ability to seek, find, understand, and appraise health information from electronic sources and apply the knowledge gained to addressing or solving a health problem.” The issue with this new age is that most consumers have access, but lack the ability to apply the knowledge that they must improve their health. The goal of this study is …

Onair: Applications Of The Nasa On-Board Artificial Intelligence Research Platform, Evana Gizzi, Conner Firth, Caleb Adams, James Berck, P. Timothy Chase Jr., Christian Cassamajor-Paul, Rachael Chertok, Lily Cloug, Jonathan Davis, Melissa De La Cruz, Matthew Dosberg, Alan Gibson, Jonathan Hammer, Ibrahim Haroon, Michael A. Johnson, Brian Kempa, James Marshall, Patrick Maynard, Brett Mckinney, Leyton Mckinney, Michael Monaghan, Robin Onsay, Hayley Owens, Sam Pedrotty, Daniel Rogers, Mahmooda Sultana, Jivko Sinapov, Bethany Theiling, Aaron Woodard, Caroline Zouloumian

Computer Science: Student Work

Infusing artificial intelligence algorithms into production aerospace systems can
be challenging due to costs, timelines, and a risk-averse industry. We introduce
the Onboard Artificial Intelligence Research (OnAIR) platform, an open-source
software pipeline and cognitive architecture tool that enables full life cycle AI
research for on-board intelligent systems. We begin with a description and user
walk-through of the OnAIR tool. Next, we describe four use cases of OnAIR for
both research and deployed onboard applications, detailing their use of OnAIR
and the benefits it provided to the development and function of each respective scenario. Lastly, we describe two upcoming planned deployments …

Spectacle And The Archipelagic Void: Mark Justiniani, Simulacra, And The Poetics Of Repetition, Luisa L. Gomez

Literary and Cultural Studies Program Faculty Publications

This paper examines the tension between spectacle and meaning in the immersive installations of Filipino artist Mark Justiniani, whose mirror-and-light works produce illusions of infinite regress. While Jean Baudrillard warns against the flattening of meaning in the era of simulacra, I argue that Justiniani repurposes the tools of spectacle to resist simulation. His “void of spectacles” stages not emptiness but layered depth, offering a spatial metaphor for archipelagic thinking—fragmented, entangled, and relational. I read Justiniani’s recursive visual structures alongside the poetics of repetition in the Filipino language, where reduplicated forms such as alaala (memory), guniguni (phantasm), bulong-bulong (rumor), or halakhak …

A Game Of Chicken: Exploring Religiosity, Gambling, And Acts Of Worship In Ren Galeno's Graphic Novel Sa Wala (Nothing To Lose), Elisha Camille Catimpo

Literary and Cultural Studies Program Faculty Publications

There are few more devout than a gambler. By his nature, he believes in something bigger than himself—be it faith, chance, luck, fortune, or some other greater power. The Philippine tradition of cockfighting, or sabong, is known for its established position in Philippine culture and the superstitious nature of the sabungero. In his 1977 book In Defense of Cockfighting, Nid Anima even goes as far as to claim that the Philippines is the cockfight Mecca of the world. In spite of the contradictory implications, there is a deep religiosity at work here, which makes the sabong unique in the Southeast …

Loyal By Nature: How Uncertainty Avoidance Shapes Dispositional Brand Loyalty, Khondoker Sayeed Hossain

Theses and Dissertations

Loyal consumers are prized assets for brands, as even minor improvements in customer retention can lead to significant increases in company profits. Most research has examined brand loyalty as a brand-specific concept and explored what brands can do to develop loyal consumers, overlooking the role of individual-level psychological and cultural factors.

This dissertation aims to address this gap by examining brand loyalty as a personality disposition and investigating its relationship with cultural values. Drawing on the extensive body of research linking culture to consumer judgments and decisions, the central hypothesis proposes that cultural values, particularly uncertainty avoidance, systematically influence individuals' …

Acute Exposure Of American Oyster (Crassostrea Virginica) To Selected Antidepressant Drug: Histological, Biochemical, And Immunohistochemical Assessments, Md. Faisal Amin

Theses and Dissertations

The rapid increase in pharmaceutical use has brought significant health benefits to humans. Studies have shown that many pharmaceuticals, such as antidepressants, are often detected in surface waters, groundwater, and even drinking water. These pharmaceuticals in aquatic environments threaten marine life seriously. Marine bivalves are vital source of seafood for people worldwide. In this study, we examined the effects of short-term exposure to fluoxetine, an antidepressant used to treat depression, at low (0.5 μg/L) and high (5 μg/L) doses over a one-week period on American oysters (Crassostrea virginica) under controlled laboratory conditions. Histological analysis revealed atrophy in the gills and …

Economic Contribution Of The Agricultural Sector To The Arkansas Economy In 2023, Frank Seo

AAES Research Reports and Research Bulletins

This report is the eighteenth in a series that examines agriculture’s economic contribution to the Arkansas economy. The total economic contribution of agriculture (direct, indirect, and induced effects) on value added, employment, and labor income was estimated with the Impact Analysis for Planning System (IMPLAN) for the most recent year available, 2023.

The Dream Of Cloth Fish, Rhea Hu, Special Collections, Fleet Library

12th Baker & Whitehill Student Artists' Book Contest 2026

Entry for the 12th Baker & Whitehill Student Artists' Book Contest. Opening reception and award ceremony Wednesday, February 25, 2026 at 6:30pm, Fleet Library, 1st Floor Main Reading Room. Juror: Gabrielle Reed.

Falling, Cindy Li, Special Collections, Fleet Library

12th Baker & Whitehill Student Artists' Book Contest 2026

Entry for the 12th Baker & Whitehill Student Artists' Book Contest. Opening reception and award ceremony Wednesday, February 25, 2026 at 6:30pm, Fleet Library, 1st Floor Main Reading Room. Juror: Gabrielle Reed.

Co-Editors' Corner, Raven L. Jones, Tanya Upthegrove Gregory, Alexandra M. Sánchez

Language Arts Journal of Michigan

Welcome to our “Co-Editors Corner,” a space where we take a moment to celebrate our personal and professional accomplishments and victories. This section is a reminder that although we shoulder so much, we’re committed to uplifting one another and ourselves. Whether we’re sharing photos of our harvests, attending conferences, freestyling, or spending time with our loved ones – we’re excited to continue to chase joy.

Green Synthesis And Characterization Of Fe-Ti Mixed Nanoparticles For Enhanced Lead Removal From Aqueous Solutions, Shamika Piumal Wishvajith Raja Hewage

All Theses

Heavy metal contamination in water resources presents a significant environmental and public health challenge, with lead a particular concern due to its toxicity and persistence. This study reports the green synthesis of Fe-Ti mixed oxide nanoparticles (NPs) using dextrose as a green source and investigates their effectiveness in lead removal from aqueous solutions. The synthesized NPs were characterized using XRD, FTIR, XPS, SEM-EDS, and BET analysis, revealing an amorphous structure with a high surface area (292.89 m² g¹) and mesoporous characteristics. XPS analysis confirmed the presence of mixed Fe³⁺/Fe²⁺ valence states in a Ti⁴⁺-rich framework, creating diverse binding sites for …

The Effect Of The Markle Mill Dam Removal On The Habitat And Riverine Food Web Of Otter Creek, Jenna Blanton

All-Inclusive List of Electronic Theses and Dissertations

Across the United States, dam removals are increasing in frequency. Despite this, the effects of dam removal on freshwater food webs are under-studied. Most existing studies investigate the impacts on fish assemblages, and very few investigate the impact on diatom, crayfish, and turtle communities. Furthermore, low-head dams are more abundant than large hydropower dams, yet the impacts of their removal are less studied than their larger counterparts. I used a Before After Control Impact (BACI) study design to survey populations of benthic diatoms, riffle-dwelling crayfish, and aquatic turtles. Species richness, species evenness, and Shannon Diversity Index values were used to …

Performance Of The Two Sample Likelihood Ratio Test Under A Nested Dirichlet: A Simulation Study, Edwina Agyeman

Electronic Theses and Dissertations

Compositional data analysis (CoDA) addresses multivariate data constrained to a constant sum, such as proportions or percentages. Originating from early warnings regarding misinterpretation by Pearson (1897), the field was formalized by John Aitchison in 1986, whose foundational work remains highly influential. Over time, new modeling techniques and visualization tools have advanced the field, as noted by Greenacre et al. More recently, Turner et al. proposed an approach based on the Nested Dirichlet Distribution (NDD), which accommodates more flexible dependence structures than the standard Dirichlet model. This thesis builds on the methodology of Turner et al. Chapter 1 introduces the nature …

Evaluating Alpha Spending Functions Applied To Observational Time-To-Event Analysis, Moses Torgbenu

Electronic Theses and Dissertations

This thesis explores the theoretical foundation of the alpha spending approach and extends its application beyond the conventional setting of randomized controlled trials (RCTs) to observational studies with time to event analyses. In these less structured environments, key design parameters such as the total number of events are often unknown, posing challenges for the standard implementation of sequential analysis methods.

Through simulation studies, this research delivers several important contributions. First, it presents a modified approach that uses calendar time to define the timing of interim analyses while relying on event-based information to estimate the correlation among test statistics. This adjustment …

Simultaneous Application Of Multiple Process Control Rules, Tran B. Ngo

Electronic Theses and Dissertations

Statistical Process Control (SPC) charts are tools used in quality control to monitor and analyze the stability of a process over time. This study evaluates the effectiveness of eight individual Western Electric rules, also known as WECO rules, and the various combinations of these rules with Shewhart rule (or WECO rule 1) to SPC charts. As more rules are added to a process control scheme with Rule 1, there is a trade-off: a higher false out-of-control signal rate but an increase in sensitivity, that is the ability of a specified process control scheme to capture a true out-of-control signal. This …