Digital Commons Network^™

Preventing Nurse Burnout And Improving Retention Rates, Abigail Rannow, Kayla Bernius, Camellia Le, Stephanie Cardenas Parra, Cesar Lopez

2024

No abstract provided.

No More Line Mix-Ups: The Label Solution, Alexis Spain, Holly Mckeethan, Lindsey Garvey, Molly Andersen, Natalie Romei, Catherine Fritz, Abigail Munoz, Kc Chamberlain

2024

No abstract provided.

Improving Ambulation And Safety Related To Complex Medical Equipment In Inpatient Settings, Kellie Chin, Allie Fox, Destiny Gaines, Luke Hernandez, Natalie Kauppila, Taylor Potraza

2024

No abstract provided.

From Bed To Better: An Interdisciplinary Approach To Establish Early Mobility & Routine Among Pediatric Hematology Oncology Patients, Emerson Emerson, Kayla Boxer, Kennedi Mcclain, Kylie Hollander, Mckenna Landon, Shannon Wheeler

2024

No abstract provided.

Cancer Therapeutic Compositions And Methods Targeting Dnaseil3, Michael J. Gough, Marka R Crittenden, Tiffany Blair

Technology Transfer - Patents

No abstract provided.

Physiological Role And Mechanisms Of Action For A Long Noncoding Haplotype Region., Hong Xue, Manoj K Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A Vanden Avond, Niharika Bala, Abdel A Alli, Allen W Cowley, Qiongzi Qiu, Andrew S Greene, Sridhar Rao, Caitlin C O'Meara, Aron M Geurts, Mingyu Liang

Faculty Research 2025

Direct targeting of noncoding genomic regions harboring common sequence variants associated with human traits through in vivo animal model studies and precise genome editing in human cells is essential for closing the critical gap between genetic discoveries and physiological understanding. However, such investigation has been impractical for many of these variants as they are in haplotypes containing multiple single-nucleotide polymorphisms (SNPs) spanning thousands of base pairs and have small effect sizes. We developed an integrated approach to address this challenge, combining an efficient two-step technique to precisely edit large haplotypes in human induced pluripotent stem cells and orthologous region deletion …

Immunosuppressive Tumor Microenvironment Of Osteosarcoma., Aaron M Taylor, Jianting Sheng, Patrick Ks Ng, Jeffrey M. Harder, Parveen Kumar, Ju Young Ahn, Yuliang Cao, Alissa M Dzis, Nathaniel L. Jillette, Andrew Goodspeed, Avery Bodlak, Qian Wu, Michael S Isakoff, Joshy George, Jessica D S Grassmann, Diane Luo, William F Flynn, Elise T Courtois, Paul Robson, Masanori Hayashi, Alini Trujillo Paolillo, Antonio Sergio Petrilli, Silvia Regina Caminada De Toledo, Fabiola Sara Balarezo, Adam D Lindsay, Bang Hoang, Stephen T C Wong, Ching C Lau

Faculty Research 2025

Background/Objectives: Osteosarcoma is the most common malignant bone tumor in children, characterized by a high degree of genomic instability, resulting in copy number alterations and genomic rearrangements without disease-defining recurrent mutations. Clinical trials based on molecular characterization have failed to find new effective therapies or improve outcomes over the last 40 years. Methods: To better understand the immune microenvironment of osteosarcoma, we performed single-cell RNA sequencing on six tumor biopsy samples, combined with a previously published cohort of six samples. Additional osteosarcoma samples were profiled using spatial transcriptomics for the validation of discovered subtypes and to add spatial context. Results: …

Diversity, Equity, And Inclusion Under Siege Worldwide: Moving Beyond Limiting Notions Of Gender And Sexuality In Education Organizations And Leadership, Margaret Grogan

Education Faculty Books and Book Chapters

As 2025 gets underway in the United States, educators across this country, like in many others, are bracing for unprecedented opposition to their diversity, equity, and inclusion (DEI) programs and policies. Newly elected President Trump is rapidly dismantling many federal agencies, cutting off aid to foreign entities, and causing major apprehension across the globe. His stated agenda to eradicate progressivism echoes many other international ultraconservative and far-right movements, who applaud his authoritarian regime. To mount the best possible resistance to these disturbing developments, and, indeed, to expand and strengthen DEI work, this chapter argues for collective action across all the …

The Brief (Edition #39, June 2025), William & Mary Law School

The Brief

No abstract provided.

Molecular Landscape Of Sex- And Modality-Specific Exercise Adaptation In Human Skeletal Muscle Through Large-Scale Multi-Omics Integration, Macsue Jacques, Shanie Landen, Adam P. Sharples, Andrew Garnham, Ralf Schittenhelm, Joel Steele, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, James Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekström, Olof Asplund, Séverine Lamon, Sarah E. Alexander, Cassandra Smith, Carlie Bauer, Mary N. Woessner, Itamar Levinger, Andrew E. Teschendorff, Linn Gillberg, Ida Blom, Jørn Wulff Helge, Nicholas Harvey, Larisa M. Haupt

Research outputs 2022 to 2026

We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcription factors functioning as activators, synergizing with DNA methylation to regulate gene expression. Minimal sex differences were observed, while modality-specific analysis highlighted distinct pathways for aerobic and resistance exercise, contrasting with muscle disuse patterns. Finally, we created a webtool, OMAx, featuring our individual omics and integration analysis. These findings provide …

7 Questions With Dr. Bear Jiang, University Of Dayton

Blog: The Dayton Engineer

We sat down with Dr. Bear Jiang, post-doc to tenure track fellow in the Department of Civil and Environmental Engineering and Engineering Mechanics, to learn more about his career and research.

Safety And Efficacy Of Repurposed Smallpox Vaccines Against Mpox: A Critical Review Of Acam2000, Jynneos, And Lc16, Mohd Wahid, Raju K. Mandal, Mohammed Sikander, Mohammad Rashid Khan, Shafiul Haque, Nachiket Nagda, Faraz Ahmad, Alfonso J. Rodriguez-Morales

School of Medicine Publications

Since 2022, outbreaks of monkeypox (Mpox), which is caused by the monkeypox virus (MPXV), have been documented in more than 116 nations, making it a serious danger to world health. Despite being self-limiting in most cases, Mpox can lead to severe illness and even death, especially among high-risk populations like the LGBTQI + community. Hence, there is an urgent need for effective prevention and treatment strategies, with vaccination playing a crucial role. This paper explores the safety and efficacy of three key vaccines; ACAM2000, JYNNEOS, and LC16 that are repurposed from smallpox vaccines to combat Mpox. ACAM2000, a replication-competent vaccinia …

Pyrene-Based Hole Transport Materials For Efficient Perovskite Solar Cells, Madiha Irfan, Aamer Saeed, Sania Tahir, Muhammad Rehman Yaqoob, Sohaib Ahmed Zia, Muhammad Usama, Junaid Mukhtar, Usama Farrukh, Sara Rehman

Turkish Journal of Chemistry

In the past few years, perovskite solar cells (PSCs) have gained a lot of attention and become a well-known topic in solar studies due to their lower manufacturing costs and improved efficiencies. Previously utilized hole transport materials (HTMs), such as poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] and 2,2ʹ,7,7ʹ-tetrakis(N,N-di-p-methoxyphenylamine)-9,9ʹ-spirobifluorene, are challenging due to their high price, complicated synthesis, limited carrier mobility, and poor device stability. Developing HTMs for PSCs that are inexpensive and high-performance has gained much interest. Currently, many HTMs of organic molecules are used to improve photovoltaic qualities and reduce synthesis costs. Effectively using HTMs is essential for producing the best photovoltaic efficiency in …

Determination Of Mitoxantrone In Environmental Waters: A Spectrophotometric Method With Preconcentration By Salt Saturated Pipette-Tip Micro Solid Phase Extraction Using Molecularly Imprinted Polymer, Sayyed Hossein Hashemi, Massoud Kaykhaii, Ahmad Jamali Keikha, Mina Esmailiun

Turkish Journal of Chemistry

In this research, a fast and simple spectrophotometric method is presented for mitoxantrone determination in various aqueous samples. It utilizes preconcentration by salt saturated pipette-tip micro solid phase extraction with a selective molecularly imprinted polymer adsorbent packed in a micropipette tip. Prior to sample loading, they were saturated with a mixture of NaCl, Mg (NO3)2.6H2O and KNO3 salts, enhancing extraction efficiency by 27.5% compared to salt-free conditions. Key microextraction parameters (amount of molecularly imprinted polymer, sample pH, eluent type/volume, and adsorption/desorption cycles) were optimized using response surface methodology and one-variable-at-a-time methods. The method achieves a low detection limit (0.2 μg …

Enhanced And Proficient Chitosan Membranes Embedded With Polyaniline-Tio2 Core-Shell Nanocomposites For Fuel-Cell Hydrogen Storage, Mallikarjunagouda Patil, Sridhar N. Mathad, Arun Y. Patil, Abdulaziz Abdulah Al-Kheraif, Sachin Naik, Sajith Vellapally

Turkish Journal of Chemistry

This study investigates the preparation and properties of aniline polymerized in situ onto a nanosized TiO2 surface to form core-shell nanoparticles at ambient temperatures. The in situ polymerization of aniline to polyaniline (PANI), in conjunction with the utilization of an anionic surfactant, was employed in this investigation. The prepared PANI-TiO2 core-shell nanoparticles were integrated with chitosan at a gravimetric ratio and cast as core-shell nanocomposite membranes. The nanocomposites were subjected to structural analysis using Fourier transform infrared spectroscopy and X-ray diffraction patterns. The surface morphologies of the PANI and its nanocomposites were analyzed using scanning electron microscopy. Direct current conductivity …

Removal Of Ddt, Ddd, And Dde From Washing Extracts Of Contaminated Soil Using Polyaniline/Bagasse Composite Material, Hop Quang Nguyen, Bach Xuan Nguyen, Thien Quang Tran, Anh Van Nguyen

Turkish Journal of Chemistry

Polyaniline (PANi) was hybridized with a bagasse (BG) substrate to treat Dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), and dichlorodiphenyldichloroethane compounds, which are persistent organic pollutants (POPs) causing environmental contamination. The PANi/bagasse (PA/BG) composite was synthesized using ammonium persulfate and sulfuric acid, achieving efficiencies ranging from 82.63% to 86.92% with different ratios of PANi monomer to BG. Infrared spectroscopy (IR) and scanning electron microscopy (SEM) were used to characterize the synthesized materials. The adsorption capacities of DDT, DDD, and DDE compounds were investigated under various conditions, including adsorbent type, adsorption time, adsorbent dosage, and adsorbate concentration. Both Langmuir and Freundlich isotherm models were …

1,3,4-Thiadiazole Derivatives As Pi3ks Inhibitor: Design, In Silico Studies, Synthesis, Characterization, And Antimicrobial Evaluation, Dharmvir Singh, Pankaj Kumar, Anoop Kumar, Vivek V. Bhosale, Kalicharan Sharma, Deepak Kumar, Ramchander Khatri, Tanuj Hooda, Amit Lather

Turkish Journal of Chemistry

Since PI3Ks are targeted by a variety of bacterial pathogens, they represent a promising target for host-directed immune therapy and may be beneficial in managing persistent bacterial infections. In the present study, computational studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives for phosphoinositide-3-kinases (PI3Ks) inhibitors were carried out using dock scores, Glide scores, and the MMGBSA dG method, with comparison to standard drugs (ofloxacin and fluconazole). A series of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives (D1-D17) were synthesized and evaluated for their in vitro antimicrobial activity against both gram-positive and gram-negative bacterial strains, as well as fungal strains, using the tube dilution method. The synthesized compounds were characterized …

Highly Sensitive And Selective Detection Of Klk4 In Human Serum With A Low-Cost Electrochemical Biosensor, Eli̇f Burcu Aydin

Turkish Journal of Chemistry

An ultrasensitive impedimetric immunosensor was fabricated using a poly(glycidyl methacrylate) (PGMA) polymer-covered indium tin oxide (ITO) platform for the quantification of kallikrein 4 (KLK4), an important prostate cancer biomarker. PGMA had suitable biocompatibility and nontoxicity for loading of antiKLK4 antibodies on the ITO substrate surface. Anti-KLK4 biomolecules were directly attached to the PGMA-covered electrode surface via epoxy groups of the PGMA polymer. The preparation method for the PGMA matrix-modified electrode was simple and inexpensive. The proposed biosensor immobilization layers coated on the ITO electrode were characterized with electrochemical techniques. The experimental parameters that affect biosensor response were optimized, and the …

Emmanuel Folly V. City Of Philadelphia

2025 Decisions

USDC for the Eastern District of Pennsylvania

Gerrett Conover V. United States Bureau Of Prisons

2025 Decisions

USDC for the Middle District of Pennsylvania

Margo Weems V. City Of Philadelphia

2025 Decisions

USDC for the Eastern District of Pennsylvania

Accounting For Stillbirths In Maternal Health Metrics: A Cross-Country Analysis Research In Context, Ursula Gazeley, Hallie Eilerts-Spinelli, Joshua Wilde, Hannah Blencowe, Li Liu, Wendy Graham, Veronique Filippi

Publications, Reports and Presentations

Background: Live birth is only one of four potential pregnancy outcomes, alongside stillbirth, miscarriage, and induced abortion. While morbidity and mortality associated with all pregnancy outcomes are included in the numerator of many maternal metrics, often only live births are included in the denominator. This inconsistency makes interpreting trends challenging and may exacerbate the deprioritisation of monitoring other pregnancy outcomes. We assess the effect of using (1) total births (live births and stillbirths) or (2) total pregnancies (total births plus miscarriages/induced abortions) as the denominator on estimates of maternal and pregnancy-related mortality ratios (MMR and PRMR). Methods: Using data from …

Quality Improvement Project Impact Of Weekly Mentorship On Compassion Fatigue In Critical Care Nurses, Susan Livengood

Doctor of Nursing Practice Projects

Compassion fatigue is defined as the physical and mental exhaustion and emotional withdrawal experienced by those who care for sick or traumatized people over an extended period. Without proactive intervention, compassion fatigue will continue to affect healthcare workers, leading to dissatisfaction in the workplace. Mentorship is an intervention that has been identified for improving the incidence of compassion fatigue. This quality improvement project implemented and evaluated a mentorship program for critical care nurses in a 227-bed acute care facility that has a 36-bed intensive care unit. The project evaluated the impact of weekly mentoring sessions on compassion fatigue in critical …

High Field Performance Of Si-Doped N-Aln Layers Grown Using Pulsed Mocvd, Abdullah Al Mamun Mazumder, Tariq Jamil, Mafruda Rahman, Muhammad Ali, Grigory Simin, Asif Khan

Faculty Publications

We report on the study of high-field performance of Si-doped n-AlN layers that were grown using a pulsed metalorganic chemical vapor deposition (PMOCVD) process. In the past we showed this pulsed doping approach to lead to doping efficiency superior to that in the conventional MOCVD process. Here using them as the drift layer for a quasi-vertical conduction Schottky barrier, we show their ability to withstand high reverse bias voltages and sustain an electrical field as high as 9.9 MV cm−1. Our study thus demonstrates the viability of the PMOCVD growth and doping approach to yield n-AlN layers suitable …

Population Genomic Investigation Of The Oregon Slender Salamander (Batrachoseps Wrighti) Reveals Suburban Populations Are Remnants, Not Recent Introductions, Clare Yang, Laura Guderyahn, Charlotte Corkran, Steven Wagner, Lauren M. Chan

Environmental Science and Management Faculty Publications and Presentations

In the face of urbanization and anthropogenic change, some native species persist while others are lost. Understanding native populations, particularly in marginal habitat, can lend insights into the effects of habitat change. The Oregon Slender Salamander (Batrachoseps wrighti) is endemic to the late-successional forests of the Cascade Range in Oregon and has declined due to land use change. In 2007, several populations of the Oregon Slender Salamander were found within highly human-modified localities in the Portland Metropolitan Region. We investigate whether these, and other newly discovered suburban populations, represent remnant populations that persisted in the face of habitat …

Leadership Development Through Coaching: A Study Of Fire Department Company Officers’ Influence On Emerging Leaders, Steven T. Denzien

Ed.D. Capstone Reports

This capstone was created to inspire junior fire department members to progress their personal leadership knowledge and style to share with the department and all their life touches. This culminated into the creation of a training program for company officers centering on equipping them with the knowledge, skills, and abilities to express leadership through the practical example of coaching.

The ADDIE (Analysis, Design, Develop, Implement, and Evaluate) model was utilized to create a dynamic method of practical education that promotes the see one, do one, teach one premise to share the principals of leadership in daily life through practice. This …

Perception Of Florida Political Actions By Higher Education, Matt Vanover Vanover

Electronic Theses and Dissertations Archive

This qualitative dissertation examines the impact of recent political actions in Florida on higher education, specifically exploring how these developments have influenced tenured, public university professors' teaching practices, student interactions, and research agendas. Guided by the theoretical framework of social constructionism and employing narrative inquiry as the methodological approach, the study captures the lived experiences of six tenured faculty members at public universities across the state. The findings indicate that Florida’s political actions of Governor Ron DeSantis and a Republican-led legislature may have led to changes in the academic landscape. Professors report self-censorship in the classroom, limited discussions of controversial …

Amateur Athletes' Psychological Experiences Of Participation-Altering And Participation-Ending Injuries, Andrew Milowsky

Electronic Theses and Dissertations Archive

Injury is a common occurrence among athletes, and research indicates that when athletes experience an injury, they frequently experience negative psychological consequences. Most of the literature related to the psychological impact of injury centers around higher-level (i.e., professional, college, and elite) athletes, with limited literature for amateur athletes who also experience injury. More specifically, there is also sparse scholarship examining the psychological impact of moderate and severe injuries for amateur athletes that experience them. Considering the gaps in the literature, the current study examined the psychological impact of participation-altering and participation-ending injuries in amateur athletes (N = 177), while also …

Jet Fuel Melts Steel Democracies: The Relationships Among Dark Personality, Belief In Conspiracy Theories, And Political Violence, Gabriel Alfaro

Electronic Theses and Dissertations Archive

Conspiracy theories are defined generally as the belief that a ‘shadowy group’ or collective is intentionally acting against one’s in-group. The last decade has seen significant sociopolitical and socioeconomic shifts, with rising antidemocratic sentiment in democracies and the COVID-19 pandemic contributing to new research on conspiracy theories. Recent studies have consistently found that dark personality traits are positively associated with belief in conspiracy theories. Other studies have also documented the potential links between conspiracy theories and antidemocratic beliefs, actions, and subsequent political violence. The present study builds on previous work examining specific conspiracy theories by exploring the relationship of dark …

June 24, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.