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Focus Group

DePaul Magazine

The DePaul Student Photo Agency gives a crew of student photographers the opportunity to develop a professional portfolio while documenting the DePaul community. See photos taken during the 2024-25 academic year, from ribbon cuttings for new program facilities to music performances.

Class Notes

DePaul Magazine

From promotions to performances, see the latest accomplishments by DePaul alumni across class years and generations. Plus, read alumni spotlight profiles of Steve Schmidt (CSH MS ’13), director of machine learning at Nike, and Sarah Brachle Wagner (LAS ’96), CEO of Chicagoland Habitat for Humanity.

Towards Scalable Schema Mapping Using Large Language Models, Christopher Buss, Mahdis Safari, Arash Termehchy, David Maier, Stefan Lee

Computer Science Faculty Publications and Presentations

The growing need to integrate information from many diverse sources poses significant scalability challenges for data integration systems. These systems often rely on manually written schema mappings, which are complex and costly to maintain. While recent advances suggest that large language models (LLMs) can assist in automating schema mapping, key challenges remain. We motivate future research in schema mapping generation by highlighting key challenges, presenting a competitive bidirectional schema matching pipeline, and exploring the limitations of current methods for generating more complex mappings.

Mechanism Of Unconventional Il-33 Release In Airway Disease, Omar Osorio

Arts & Sciences Graduate Student Theses and Dissertations

The alarmin cytokine IL-33 is a strong inducer of type two inflammation and has been implicated in various chronic lung diseases. Although much work has been done to understand the inflammatory effects of extracellular IL-33, there is still a knowledge gap in understanding how this cytokine is secreted by airway epithelial cells in steady-state conditions. In the work laid out in this document, a COPD-disease associated isoform of IL-33, that has exons 3 and 4 (IL-3334) spliced out and is tonically secreted at baseline conditions. This IL-33 isoform is secreted from airway epithelial cells alongside, or as part of, extracellular …

Revisiting The Effect Of Udenafil On Exercise Performance In Patients With Fontan Circulation: Results Of A Post Hoc Analysis Of The Fuel Trial, David J Goldberg, William B Orr, Et Al.

2020-Current year OA Pubs

BACKGROUND: In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo

METHODS: Participants were divided into subgroups by baseline predicted peak Vo

RESULTS: Of the 379 participants with paired exercise data, 302 (80%) had a baseline peak Vo

CONCLUSIONS: In this post hoc subgroup analysis, after exclusion of patients with Fontan circulation with near-normal baseline peak Vo

REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT0274115.

Corticotropin-Releasing Hormone Modulates Nrem Sleep Consolidation Through The Thalamic Reticular Nucleus, Loredana Cumpana, Olivia Zanoletti, Dinesh Kankanamge, Bryan Copits, Carmen Sandi, Simone Astori

2020-Current year OA Pubs

Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, remained unexplored. Combining polysomnographic and photometric recordings in mice, we show that CRH release in TRN during non-rapid-eye movement sleep (NREMS) oscillates with a ~50-s periodicity, anti-correlating with sleep spindle dynamics. Optogenetic manipulations of CRH release in TRN modulated NREMS fragmentation through microarousals with corresponding changes in sigma and delta power. In ex-vivo …

Computer-Automated Systems And Methods For Using Language Models To Generate Text Based On Reading Errors, Scott Sosso, Siyu Chen, Ciara Figliuolo, Jack Mostow, Marlies Goes

AFIT Patents

A computer-implemented system and method generate personalized text based on statistics derived from input received from a user representing the user's attempts to decode graphemes into phonemes. Such statistics may be measured and recorded at the grapheme-phoneme level, and may include substitutions, insertions, deletions, and correct utterances of phonemes by the user when reading text. A language model may be trained based on characteristics of the user, such as the user's age and/or reading grade level, and the personalized text may be generated after such training of the language model. Generating the personalized text may include generating a text creation …

2025 August 19 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Exploring Neuropsychiatric Manifestations Of Vitamin B Complex Deficiencies, Anamaria Han, Leandro Almeida, Nikhilesh Anand, Ihsan Salloum, Salim Kanaan, Bharathi Gadad, João Paulo Lima Daher

School of Medicine Publications

B complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy production. Thiamine is involved in the Krebs cycle, riboflavin in the electron transport chain, and niacin plays a key role in both glycolysis and the Krebs cycle. These metabolic processes are vital for sustaining the integrity of the nervous system, as the energy produced is critical for the functioning of nerve cells. Deficiencies in these vitamins can lead to significant neurological and psychiatric conditions, including …

Therapeutic Targeting Of Syndecan-1 Axis Overcomes Acquired Resistance To Kras-Targeted Therapy In Gastrointestinal Cancers, Madelaine S Theardy, Mitsunobu Takeda, Alexey Sorokin, Shuaitong Chen, Zecheng Yang, Preeti Kanikarla, Phuoc Nguyen, Yongkun Wei, Jun Yao, Liang Yan, Yanqing Jin, Yiming Cai, Masakatsu Paku, Ziheng Chen, Kara Z Li, Francesca Citron, Hideo Tomihara, Sisi Gao, Angela K Deem, Jun Zhao, Huamin Wang, Samir Hanash, Ronald A Depinho, Anirban Maitra, Giulio F Draetta, Haoqiang Ying, Scott Kopetz, Wantong Yao

Faculty, Staff and Student Publications

The therapeutic benefit of recently developed mutant KRAS (KRAS∗) inhibitors remains limited by the rapid onset of resistance. Here, we aim to delineate mechanisms underlying acquired resistance and identify actionable targets for overcoming this clinical challenge. Previously, we identified syndecan-1 (SDC1) as a key effector for pancreatic cancer progression whose surface expression is driven by KRAS∗. By leveraging both pancreatic and colorectal cancer models, we show that surface SDC1 expression initially diminishes upon KRAS∗ inhibition but recovers in tumor cells that bypass KRAS∗ dependency. Mechanistically, we reveal that YAP1 activation drives the recovery of SDC1 surface localization to enhance macropinocytosis-mediated …

Optimizing Motion Management And Baseline Shifts In Magnetic Resonance-Guided Spine Stereotactic Body Radiation Therapy, Yao Ding, Travis C Salzillo, Debra N Yeboa, Martin C Tom, Zhiheng Wang, Ergys Subashi, Todd Swanson, Thomas Beckham, Chenyang Wang, Amol J Ghia, Tina Briere, Jihong Wang, Fabienne Lathuilière, Sneha Cloake, Eun Young Han

Faculty, Staff and Student Publications

BACKGROUND: Stereotactic body radiation therapy (SBRT) has proven effective in controlling spinal lesions with minimal toxicity, primarily due to its ability to limit spinal cord dose. Recent advances in MR-linac (MRL) technology offer superior spinal cord visualization and real-time gating, which can facilitate dose escalation in spinal tumor treatment while maintaining safety.

PURPOSE: This study aimed to optimize motion management for spine SBRT on an MRL by analyzing patient-specific motion dynamics and evaluating the most effective registration structures. We hypothesized that baseline shifts (BLS) would improve delivery efficiency while maintaining spinal cord dose constraints. The goal was to establish displacement …

Trpc4 Regulates Limbic Behavior And Neuronal Development By Stabilizing Dendrite Branches Through Actomyosin-Driven Integrin Activation, Jaepyo Jeon, Travis I Moore, Insuk So, Marc Freichel, Veit Flockerzi, Michael X Zhu

Faculty, Staff and Student Publications

Transient Receptor Potential Canonical 4 (TRPC4) channels have been implicated in multiple neurological functions, including anxiety and sociability. TRPC4 variants were also found in patients with autism. However, the contributions of TRPC4 to neurodevelopment remain undefined. Here, we show that neurobehavioral deficits appear early in young TRPC4 knockout (Trpc4^−/−) mice immediately after weaning, manifesting as alterations in multiple, limbic-related behaviors, such as nesting, marble burying, burrowing, self-grooming, and social interactions. Hippocampal neurons of Trpc4−/− mice exhibit reduced dendritic arborization both in vivo and in vitro. Mechanistically, we found that TRPC4 expression in dendrites surged at the …

A Brief History Of Circadian Time In The Heart, Martin E Young, Vanya Khanna, Mallory Metcalfe, Niruththaan Rameshkumar, Sarah Harington, Janan Shoja Doost, Tami A Martino

Faculty, Staff and Student Publications

This review tracks the discovery of circadian biology in cardiovascular science, starting with early clinical observations of daily changes in heart rate, blood pressure, and cardiovascular events. These patterns suggested that time of day matters, but it was not until the past two decades that the mechanisms and knowledge translation of these rhythms were uncovered. We describe the heart's intrinsic circadian properties and importantly how this leads to regulation of cardiac gene and protein expression, neuroendocrine and vascular rhythms, metabolism, cellular electrophysiology, and cell signaling pathways. Next, we explore emerging themes, including the impact of circadian timing on ischemic injury, …

Causes Of Symptoms And Symptom Persistence In Long Covid And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Anthony L Komaroff, Robert Dantzer

Faculty, Staff and Student Publications

Debilitating symptoms for many years can follow acute COVID-19 ("long COVID"), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and various post-acute infection syndromes (PAISs). Together, long COVID and ME/CFS affect 60-400 million individuals, globally. Many similar underlying biological abnormalities have been identified in both conditions including autoantibodies against neural targets, endothelial dysfunction, acquired mitochondrial dysfunction, and a pro-inflammatory gut microbiome. Each of these abnormalities may directly cause some of the symptoms. In addition, the symptoms also may be caused by ancient, evolutionarily conserved symptomatic and metabolic responses to vital threats-sickness behavior and torpor-responses mediated by specific, recently discovered neural circuits. These neural …

An Educational Intervention Focused On Identifying Adverse Childhood Experiences, Laconia Bacon

Walden Dissertations and Doctoral Studies

Adverse childhood experiences (ACEs) refer to traumatic childhood experiences that individuals may have been exposed to during their youth, such as child maltreatment, domestic violence, or interparental violence. Research has demonstrated that experiencing ACEs in childhood may result in physical and mental illnesses that led to dangerous lifestyle patterns in adulthood. In the local organization, several patients with ACEs presented in the emergency department (ED). The nurses, unaware of ACEs, were unable to detect and respond to the consequences of ACEs. Thus, the purpose of this Doctor of Nursing Practice (DNP) project was to determine whether an educational intervention focused …

Strategies For Volunteer Firefighter Recruitment And Retention, Teddy Gene Abbey

Walden Dissertations and Doctoral Studies

Volunteer fire departments (VFDs) provide essential services in rural areas that cannot afford full-time staff, and they are negatively impacted by declining recruitment and retention. VFD administrators who lack strategies to recruit and retain volunteer firefighters risk reduced emergency services and increased costs for hiring paid firefighters. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative pragmatic inquiry project was to identify and explore strategies some VFD administrators use to recruit and retain members and maintain necessary emergency services. Participants were six administrators from VFDs in Oklahoma and Arkansas with community populations of 1,500 citizens or fewer residents who …

Women Veterans' Use Of Gender-Specific, Online, Social Support Systems For Social Identity After Military Service, Katie M. Baillio

Walden Dissertations and Doctoral Studies

The number of women veterans serving in the military is growing. This qualitative study explored women veterans' perspectives and experiences with gender-specific online social support services, and how that contributes to their social identity after military service. A generic qualitative design was used, and data were collected through semistructured interviews for 10 women veterans who had transitioned out of the military within the last 5 years. Five themes emerged: (a) big picture: connecting with other women veterans was helpful; (b) veteran forums were used for federal or state benefits, but women used gender-specific forums for questions specific to women's issues; …

The Perceived Impact Of Officer-Involved Domestic Violence On Law Enforcement Administrators, Victoria Smith

Walden Dissertations and Doctoral Studies

The frequency of officer-involved domestic violence (OIDV) is a serious problem in the law enforcement profession. This qualitative phenomenological study aimed to determine what measures and specific domestic violence policies are working well and what is working poorly in Florida. This study is critical because it can aid upcoming law enforcement administrators (LEAs) and current LEAs in improving the policies and measures they use in their agency to combat OIDV among their officers and recruits. Jacques’s organizational culture theory (OCT) provided a framework for this study. I used purposeful snowball sampling methods to recruit participants for this study. Six law …

Effects Of Social Influences On Adult Male Politicians Who Engage In Sexually-Exploitative Behaviors, Rodshana M. Ulery

Walden Dissertations and Doctoral Studies

Sexually-exploitative behaviors by adult male politicians is a significant societal concern that reflects deeper issues involving power misuse, gender inequality, and institutional failure. This qualitative research involved examining societal factors that were linked with this type of misconduct. Guided by the status characteristics theory, the study involved examining how status-related traits such as political power, public image, and institutional affiliation shaped social dynamics and fostered environments that enabled these behaviors. Using NVIVO, thematic content analysis was applied to 24 adult male politician cases. Five key themes emerged: early life and family influences, position and power, opportunity expectations, cultural and institutional …

Educating Nurses On The Agency Of Healthcare Research And Quality Pressure Ulcer Prevention Program To Reduce The Rate Of Pressure Ulcers, Marie France Destaul

Walden Dissertations and Doctoral Studies

A staff development project was conducted to address the practice problem encountered in a healthcare setting. The identified gap in practice was related to a lack of knowledge of pressure ulcer injury prevention among inpatient staff. Leadership deemed it essential to address this practice problem in nursing care because the prevalence of pressure ulcer injuries in hospitalized patients was high. The following practice-focused question guided the project: For staff in an inpatient setting, will education on the Agency of Healthcare Research and Quality (AHRQ) Pressure Ulcer Prevention Program increase knowledge toward the goal of decreasing the incidence of pressure ulcers? …

A Qualitative Study On The Experiences Of Burnout Among Mental Health Practitioners Rendering Clinical Care During Covid-19, Mykiyaa Marvella Walker-Sanchez

Walden Dissertations and Doctoral Studies

Prior to the COVID-19 pandemic, between 21% and 67% of mental health practitioners in the United States experienced signs of burnout. The pandemic exacerbated these challenges, with an increased demand for mental health services. By 2022, 45% of practitioners reported burnout, and the APA’s 2023 Practitioner Pulse Survey noted that psychologists were working at the limits of their capacity, with high levels of burnout. While research on COVID-19 and burnout has expanded for physicians and nurses, less focus has been placed on mental health practitioners' experiences. The purpose of this generic qualitative study aimed to understand how mental health practitioners …

Enhancing Co-Occurring Disorder Screening In Outpatient Substance Abuse Patients, Christianah Farinloye

Walden Dissertations and Doctoral Studies

Co-occurring disorders (CODs) are often underdiagnosed in outpatient behavioral health settings due to fragmented care and lack of standardized, interprofessional screening. Mental health professionals lack unified screening guidelines for CODs, limiting early detection and coordinated care, especially in high-risk populations. This project aims to develop an evidence-based clinical practice guideline (CPG) to promote interprofessional consensus and improve COD screening and management. Guided by the Johns Hopkins EBP Model and the AGREE II instrument to ensure rigor. Twelve expert reviewers (5 PMHNPs, 4 LCPCs, and 3 psychiatrists) assessed a CPG developed from nine critically appraised studies sourced from EBSCO, CINAHL, and …

Canada’S Indigenous Social Workers’ Medicinal Plant Knowledge: A Land-Based Way Of Knowing For Indigenous Practice, Iris Kim Plain Eagle

Walden Dissertations and Doctoral Studies

Canada’s Indigenous people of Treaty 7 region have experienced intergenerational trauma resulting from colonization perpetrated by the Canadian government. While the use of medicinal plants, are employed by Indigenous social workers, their integration into mainstream human services organizations remains limited. The gaps in Indigenous social work practice hinders client culturally competent care and the acknowledgement of Indigneous knowledge systems in colonial systems. This generic qualitative study explored the experiences of participants who integrate medicinal plant healing and ancestral knowledge into practice. Informed by indigenous wholistic theory, the study aimed to understand how Indigenous social workers navigate the challenges and opportunities …

Extraction-Free Rt-Rpa Assay For Detection Of Hpv16, Hpv18, And Hpv45 Mrna Expression, Megan M Chang, Cannon J Hansen, Jane Richards Montealegre, Michael E Scheurer, Philip E Castle, Ming Guo, Mila P Salcedo, Kathleen Schmeler, Rebecca Richards-Kortum

Faculty, Staff and Students Publications

Messenger RNA (mRNA) from high-risk genotypes of human papillomavirus (hrHPV) is a more specific biomarker for cervical cancer risk than hrHPV DNA due to its ability to differentiate clinically significant infections from transient ones. Detecting mRNA from exfoliated cervical cells, however, is a complex, expensive, and equipment-intensive process, making it infeasible in resource-limited settings. Here we describe a sensitive, specific, and minimally instrumented method to detect HPV16, HPV18, and HPV45 mRNA in exfoliated cervical cells. First, reverse transcription recombinase polymerase amplification (RT-RPA) exo assays were designed to amplify and detect HPV16, HPV18, and HPV45 E7 mRNA ≥100 copies per reaction …

Evaluation Of Fano Resonance In Silver Nanotriangles And Complementary Triangular Apertures For Enhanced Refractive Index Sensing, Nabila Islam

Dissertations and Theses

This thesis presents a detailed investigation of plasmonic sensors based on silver (Ag) nanotriangles, focusing on the interaction of plasmonic mode with waveguide modes to achieve Fano resonance for enhanced refractive index sensitivity. For this purpose, Ag nanotriangles were chemically synthesized and were on indium tin oxide (ITO)-coated glass. The samples were illuminated with laser light of various wavelengths and polarization to excite surface plasmon in the nanotriangle. Observation and characterization of their plasmonic behavior was done experimentally using Photoemission Electron Microscopy (PEEM). Numerical simulations using the Finite Element Method (FEM) were performed that agreed with these experimental results and …

Changes In Self-Reported Excessive Daytime Sleepiness Are Associated With 5-Year All-Cause Mortality Risk Among Veterans, Drew A Helmer, Amir Sharafkhaneh, Javad Razjouyan

Faculty, Staff and Students Publications

Excessive daytime sleepiness (EDS) is linked to adverse clinical outcomes. This study evaluated changes in a validated tool to assess EDS, the Epworth Sleepiness Scale (ESS) and mortality risk. This retrospective cohort study included Veterans receiving sleep-related services in the Department of Veterans Affairs (VA) from October 4, 1999 to August 18, 2018, with two qualifying ESS measures. ESS values were extracted from patient notes using a validated natural language processing (NLP) pipeline (96% accuracy). ESS scores were categorised as Normal (0-10) or Abnormal (11-24). Patients were grouped based on ESS changes: Normal-Normal, Normal-Abnormal, Abnormal-Abnormal and Abnormal-Normal. Cox proportional hazards …

Proteogenomic Characterization Unveils Biomarkers Associated With Chemoresistance In Muscle-Invasive Bladder Cancer, Alexander B Saltzman, Meenakshi Anurag, Jonathan T Lei, Antrix Jain, Mei Leng, Beom-Jun Kim, Lacey E Dobrolecki, Stefanie F Faucher, Sara Savage, Chenwei Wang, Zhiao Shi, Hugo Villanueva, Karoline Kremers, Kyle D Drinnon, Patricia D Castro, Michael M Ittmann, Mehak Mehboob Khatani, Sung Han Kim, Matthew J Ellis, Bing Zhang, Anna Malovannaya, Seth P Lerner

Faculty, Staff and Students Publications

To explore potential chemoresistance mechanisms and identify therapeutic opportunities in muscle-invasive bladder cancer (MIBC), we conduct comprehensive proteogenomic characterization of 46 pre- and 14 post-treatment MIBC tumors incorporating genomics, transcriptomics, proteomics, and phosphoproteomics. Multi-omics clustering not only recapitulated established molecular subtypes but also revealed subtypes associated with chemotherapy sensitivity. Protein isoform level analysis identifies protein abundance of a short isoform of ATAD1 and RAF family proteins as biomarkers of chemosensitivity. Integration of proteomic and phosphoproteomic data reveals Wnt signaling via GSK3B-S9 phosphorylation and the JAK/STAT pathway as potential targets to overcome chemoresistance. Correlations between PD-L1 and TROP-2/NECTIN-4 indicate an additive …

Strategies To Recommend Compliance For Cna Staffing Ratios In New Jersey Nursing Homes, Mira Gaba

Walden Dissertations and Doctoral Studies

Skilled nursing facilities (SNFs) in New Jersey, which provide both short-term rehabilitation and long-term residential care, are faced with mounting pressure due to mandated staffing ratios for certified nursing assistants (CNAs). The purpose and review question for this integrative review centered on best practices and strategies for nursing home leaders to meet the new Centers for Medicare & Medicaid Services and New Jersey standards for CNA staffing ratios in nursing homes. This review used the systems theory to look at SNFs as connected networks where staffing, leadership, finances, and care delivery all work together. An examination of the literature published …

Strategies To Improve Psychiatrist Understaffing In Psychiatric Hospitals In Rural And Underserved Communities: Addressing Administrative Challenges, Carla Aramouni

Walden Dissertations and Doctoral Studies

Psychiatric hospitals across the United States face a worsening shortage of psychiatrists, particularly in rural and underserved communities, which limits timely mental health care, increases wait times, and places unsustainable strain on the psychiatric workforce. The purpose of this integrative review was to identify administrative strategies that can mitigate psychiatrist understaffing and support sustainable care delivery in psychiatric hospitals. An integrative review methodology was used to explore both empirical and nonempirical literature, resulting in 92 articles, including 32 peer-reviewed sources and several supporting studies selected through a systematic search, screening, and critical appraisal. Thematic analysis of the evidence revealed five …

Ethical Considerations Of Deep Brain Stimulation For Treatment Refractory Schizophrenia: Surveying Stakeholders, Stephanie Lehto, Patrick Hosokawa, Paul S Appelbaum, Akira Sawa, Jocelyn Lippman-Bell, William S Anderson, Wayne Goodman, Sameer A Sheth, Daniel Kramer, John A Thompson, Elyn R Saks, Rachel A Davis

Faculty, Staff and Students Publications

Introduction: Ethical concerns have been raised by both current and historically controversial neurosurgical interventions for treatment-refractory schizophrenia and schizoaffective disorder (TR-SZ). Considering advances in next-generation deep brain stimulation (DBS), initial success in treating a few cases of TR-SZ, and how challenging trial enrollment is, transparency and disseminating knowledge about DBS is important, as is input from involved groups. Here information was presented about DBS as an experimental treatment option for TR-SZ to stakeholders to gauge enthusiasm after consideration of potential risks and benefits.

Methods: Stakeholders were presented with information about DBS (total n = 629). Opinions about whether DBS should …