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Articles 156061 - 156090 of 5149642
Full-Text Articles in Entire DC Network
Shock Induced Droplet Aerobreakup For Newtonian And Non-Newtonian Fluids, James Leung
Shock Induced Droplet Aerobreakup For Newtonian And Non-Newtonian Fluids, James Leung
LSU Doctoral Dissertations
This research investigates shock-induced aerodynamic breakup (aerobreakup) of fluids with different stress-strain behaviors. The central hypothesis is that shear stress from highspeed gas flow manifests differently depending on a fluid’s strain response, influencing droplet breakup morphology, fragment size distribution, and drag-induced acceleration. To test this, experiments and simulations were performed on μm–mm sized droplets of Newtonian (water) and shear-thinning fluids (nanofluids or xanthan gum). Two experimental setups were used: an open-ended shock tube and a closed conventional shock tube. In the openended setup, a normal shock impacts a stationary droplet held by an acoustic levitator. Droplet breakup and gas dynamics …
Committee's Reply To Parishes' Objection To Derivative Standing
Committee's Reply To Parishes' Objection To Derivative Standing
Catholic Dioceses in Bankruptcy
No abstract provided.
Unearthing Evidence For St. Augustine’S Racial Blackness And Paralleling Augustine’S Christian Mystical Religion To Traditional African Religion’S Mysticism, Dillon Cook
Say Something Theological: The Student Journal of Theological Studies
This article undertakes two projects rendering significant ramifications for philosophy/theology, if my assertions are correct. First, the philosopher/theologian known as St. Augustine of Hippo is most saliently recognized as a “white man”; if not a white man, “a European”; if not European, “a man of Rome”; or “Mediterranean”; etc. Outside the intellectual sphere, this is how he is often depicted in art, Penguin Classic books, and so on. Yet ironically, images of Augustine rarely circulate, if at all, as a Black-African-Indigenous person. Was Augustine nonwhite? Evidence is rendered that this is indubitably the case. Could Augustine have been modernly categorized …
Voices Of Protest: Women Who Sing The Blues, Deborah Kaufman Giordano
Voices Of Protest: Women Who Sing The Blues, Deborah Kaufman Giordano
Say Something Theological: The Student Journal of Theological Studies
This paper explores the biblical and historical continuity of women’s voices “singing the blues” in social protest across different contexts. The blues as a musical genre spans a myriad of themes, including social protest. Black female blues songs such as Bessie Smith’s “Poor Man’s Blues” and Billie Holiday’s “Strange Fruit” were the blues songs of lament and social protest, protesting economic injustice and the brutality of lynching respectively. This paper explores how two biblical women — Hannah in “Hannah’s Song” (1 Samuel 2:1-10) and Mary in the Magnificat (Luke 1:46-55) — sang the blues of social protest. These biblical women, …
Augustine’S Ethics And Authentic Happiness, Ignatius C. Williams
Augustine’S Ethics And Authentic Happiness, Ignatius C. Williams
Say Something Theological: The Student Journal of Theological Studies
Finding happiness is a fundamental human goal, despite the fact that it varies between cultures, philosophical systems, and religious beliefs. But how mankind pursues happiness as the greatest good and how it is reached in that process are considered because not all endeavors ultimately lead to true or authentic happiness. In light of this, Augustine’s notion of ethics and authentic happiness are examined, along with some essential principles for living an ethical life that is congruent with true happiness. Three topics are explored. First, I examined Augustine’s theory of happiness as well as moral requirements centered on grace, love, and …
Discord From Within: Challenges Facing Catholicism In The United States And The Road Ahead, Amber Montgomery
Discord From Within: Challenges Facing Catholicism In The United States And The Road Ahead, Amber Montgomery
Say Something Theological: The Student Journal of Theological Studies
As membership in the Catholic Church continues to decline in the United States, there are less parishioners or those interested in religious life. Two contributing reasons for this include the Church’s stance on the use of contraception and the role of women within ministry. Explored here is a brief survey of these issues based on Scripture, papal documents, feminist theology, and the perspective of clergy and lay persons. These two topics are of particular interest as the United States grapples with women’s rights over their bodies and wrestle with women’s place within the Church. While the Church has taken an …
Reaching The Young And Hopeless: Rooting For Redemption At A Residential Treatment Center, Christian P. Newton
Reaching The Young And Hopeless: Rooting For Redemption At A Residential Treatment Center, Christian P. Newton
Say Something Theological: The Student Journal of Theological Studies
This article reflects on my experiences as an educator at a Residential Treatment Center, observing the spiritual battles being fought by some residents as they attempt to rectify their lives after their involvement in sexual abuse. It will review literature that has been successful in my classroom with helping young people change their mind concerning their irredeemableness and that can also improve how evangelical attempts across Christian dominations pastor to those who feel scorned by God. Due to the mentality of some residents who have deeply struggled with the concepts of forgiveness and regret, literature is offered as starting point …
Investigating The Relationships Among Suspended Sediment Concentration, And Marsh Edge Erosion In Barataria Bay, La, Lily Vowels
Investigating The Relationships Among Suspended Sediment Concentration, And Marsh Edge Erosion In Barataria Bay, La, Lily Vowels
LSU Master's Theses
Barataria Bay, Louisiana, USA exhibits a unique microtidal, wind-driven hydrodynamic climate where extensive levee infrastructure throughout Louisiana has starved Barataria Bay and similar interdistributary bays of the historic levels of terrigenous sediment import. This has contributed to extreme coastal wetland loss in Louisiana. This project seeks to understand how hydrodynamic and meteorological conditions are linked to sediments’ fate after erosion from the marsh edge. Specifically, this project seeks to differentiate the roles of wave resuspension and marsh edge erosion (MEE) in sediment dynamics in Barataria Bay. An acoustic wave and current profiler (AWAC) was used to capture hydrodynamic conditions, and …
From Devices To The Cloud: Digital Forensics In The Changing Social Media Landscape, Joseph Brown
From Devices To The Cloud: Digital Forensics In The Changing Social Media Landscape, Joseph Brown
LSU Master's Theses
This thesis presents a comprehensive digital forensic analysis of emerging and alternative social media platforms, including Truth Social, Threads, Bluesky, Nextdoor, and Neighbors. These platforms, which range from politically aligned alt-tech networks to hyperlocal neighborhood apps, present unique forensic challenges and security vulnerabilities. Across all case studies, established forensic techniques were applied using a hybrid methodology combining mobile device analysis, network traffic monitoring, and API interrogation. Findings include the discovery of plaintext credentials, session tokens, and other sensitive artifacts, particularly in platforms with weaker security postures such as Truth Social, Bluesky, Nextdoor, and Neighbors. Threads, by contrast, demonstrated greater resilience …
Effects Of Oxygen Manipulation On Myofibroblast Phenotypic Transformation In Patients With Radiation-Induced Fibrosis, Eric Mastrolonardo, Sarah Sussman, Bo Yun, Victor Jegede, Dev Amin, Joel Rosenbloom, Andrew P. South, Voichita Bar-Ad, Peter J Wermuth, Adam J. Luginbuhl
Effects Of Oxygen Manipulation On Myofibroblast Phenotypic Transformation In Patients With Radiation-Induced Fibrosis, Eric Mastrolonardo, Sarah Sussman, Bo Yun, Victor Jegede, Dev Amin, Joel Rosenbloom, Andrew P. South, Voichita Bar-Ad, Peter J Wermuth, Adam J. Luginbuhl
Department of Otolaryngology - Head and Neck Surgery Faculty Papers
We tested if hyperoxic conditions can reduce the proportion of active myofibroblasts, which are assumed to be a major driver of head and neck radiation-induced fibrosis, as measured by expression levels of pro-fibrotic genes. Radiated, non-cancerous soft tissue from the head and neck and skin/soft tissue from non-radiated flap donor site were collected from each patient. Myofibroblast density was quantified using immunofluorescence staining with α-SMA and DAPI and visualisation under confocal microscopy and compared between baseline non-radiated and radiated tissue from the same patient. From each tissue specimen, fibroblast cell lines were cultured and exposed to either normoxic, hypoxic, or …
Analog Chip May Be Key To Unlocking Ai Power, Jordan Karnbach
Analog Chip May Be Key To Unlocking Ai Power, Jordan Karnbach
University of Mississippi News
OXFORD, Miss. – Most computers use digital systems that separate memory, where data is stored, and processing, where it is used. This setup wastes energy because the computer must constantly move data back and forth, but a University of Mississippi professor is working to develop a more efficient alternative.
$1m+ Grant Supports Kessler Scholars Program For First-Generation College Students, University Of Dayton
$1m+ Grant Supports Kessler Scholars Program For First-Generation College Students, University Of Dayton
News Releases
The University of Dayton will receive $1.1 million from Bloomberg Philanthropies and the Judy and Fred Wilpon Family Foundation for the Kessler Scholars program for students in the UD Sinclair Academy who are the first in their families to pursue a four-year degree.
Influence Of Zinc Oxide Nanoparticles On The Efficiency Of Oxytetracycline Removal From Wastewater Using Continuous Catalytic Ozonation, Sarmad Al-Anssari, Hassanain A. Hassan, Maha K. Mohsin, Ahmed A. Mohammed
Influence Of Zinc Oxide Nanoparticles On The Efficiency Of Oxytetracycline Removal From Wastewater Using Continuous Catalytic Ozonation, Sarmad Al-Anssari, Hassanain A. Hassan, Maha K. Mohsin, Ahmed A. Mohammed
Research outputs 2022 to 2026
Antibiotics must be fully eliminated before they are released into the environment. In most cases, conventional wastewater treatment systems are not built to handle polar microcontaminants such as antibiotics. Oxytetracycline (OTC) is one of these antibiotics, an environmental hazard contaminant in aqueous solutions. Therefore, an advanced treatment method is needed for wastewater contaminated with antibiotics. In this study, we employed zinc oxide nanoparticles (ZnO), and the catalytic ozonation procedure was employed to increase the ozonation efficiency. A continuous experiment was carried out to compare the effectiveness of catalytic and single ozonation in degrading OTC in a continuous reactor. The flow …
Public Support For Puma Reintroduction In The Eastern United States, L. Mark Elbroch, Jazmin J. Murphy, Shelby C. Carlson, John A. Vucetich, Richard E.W. Berl, Lexi Galiardi, Shelby Perry, Tom Butler, Neil Carter, Joseph W. Hinton, Axel Moehrenschlager, Emily Carrollo, Rana Bayrakcismith, Jeremy T. Bruskotter
Public Support For Puma Reintroduction In The Eastern United States, L. Mark Elbroch, Jazmin J. Murphy, Shelby C. Carlson, John A. Vucetich, Richard E.W. Berl, Lexi Galiardi, Shelby Perry, Tom Butler, Neil Carter, Joseph W. Hinton, Axel Moehrenschlager, Emily Carrollo, Rana Bayrakcismith, Jeremy T. Bruskotter
Michigan Tech Publications
Pumas (Puma concolor) are among the species identified as having the potential to enhance ecosystem function. Previous research highlights sufficient ecological habitat to support pumas in the eastern United States; however, their reintroduction requires social and institutional support as well. To this end, we conducted research to assess attitudes about puma reintroduction among key constituencies like hunters, rural residents, and young people. We sampled 2756 respondents across seven states (Massachusetts, Maine, New Hampshire, New York, Pennsylvania, Vermont, and West Virginia). Ratios of strong support (for puma reintroduction) to strong opposition across states ranged from 4:1 to 13:1, and support outweighed …
Uncharted Territory: The First Case Of Cardiac Myxoma In A Patient With Nf2, Muhammad Sabri, Zinya Talukder, Naila Ijaz, Joseph Neri
Uncharted Territory: The First Case Of Cardiac Myxoma In A Patient With Nf2, Muhammad Sabri, Zinya Talukder, Naila Ijaz, Joseph Neri
Rothman Institute Papers
BACKGROUND: Cardiac myxoma is a benign tumor, typically originating in the left atrium, and is often linked to Carney complex. In our literature review, there are no case reports of cardiac myxoma in patients with neurofibromatosis type 2 (NF2).
CASE SUMMARY: A 60-year-old man presented with dizziness and was found to have meningioma and vestibular schwannoma, consistent with NF2. Cardiac myxoma was incidentally diagnosed through echocardiography and confirmed by cardiac magnetic resonance imaging and tissue pathology. The mass was surgically resected. The patient was offered genetic testing; however, he decided to not undergo further testing.
DISCUSSION: NF2 is an inherited …
Ai Regulation: Competition, Arbitrage & Regulatory Capture, Filippo Lancieri, Laura Edelson, Stefan Bechtold
Ai Regulation: Competition, Arbitrage & Regulatory Capture, Filippo Lancieri, Laura Edelson, Stefan Bechtold
Georgetown Law Faculty Publications and Other Works
The commercial launch of ChatGPT in November 2022 and the fast development of large language models have catapulted the regulation of artificial intelligence to the forefront of policy debates. A vast body of scholarship, white papers, and other policy analyses followed, outlining ideal regulatory regimes for AI. The European Union and other jurisdictions have moved forward by regulating AI and LLMs. One overlooked area is the political economy of these regulatory initiatives—or how countries and companies can behave strategically and use different regulatory levers to protect their interests in the international competition on how to regulate AI.
This Article helps …
One-Year Clinical Outcomes In Patients With Acute Coronary Syndrome Treated With Clopidogrel Versus Prasugrel Versus Ticagrelor: Results Of The Polish Registry Of Acute Coronary Syndromes (Pl-Acs), Julia M. Umińska, Michał Skrzypek, Małgorzata Ostrowska, Piotr Adamski, Aldona Kubica, Piotr Niezgoda, Robert Gajda, Marek Gierlotka, Bartosz Hudzik, Wiktor Kuliczkowski, Diana A. Gorog, Paul A. Gurbel, Jolanta Siller-Matula, Łukasz Szarpak, Michael Savage, Grzegorz Skonieczny, Udaya Tantry, Przemysław Trzeciak, Eliano P. Navarese, Jacek Kubica, Mariusz Gąsior
One-Year Clinical Outcomes In Patients With Acute Coronary Syndrome Treated With Clopidogrel Versus Prasugrel Versus Ticagrelor: Results Of The Polish Registry Of Acute Coronary Syndromes (Pl-Acs), Julia M. Umińska, Michał Skrzypek, Małgorzata Ostrowska, Piotr Adamski, Aldona Kubica, Piotr Niezgoda, Robert Gajda, Marek Gierlotka, Bartosz Hudzik, Wiktor Kuliczkowski, Diana A. Gorog, Paul A. Gurbel, Jolanta Siller-Matula, Łukasz Szarpak, Michael Savage, Grzegorz Skonieczny, Udaya Tantry, Przemysław Trzeciak, Eliano P. Navarese, Jacek Kubica, Mariusz Gąsior
Division of Cardiology Faculty Papers
BACKGROUND: Efficient dual antiplatelet therapy is crucial in reducing adverse cardiovascular events in patients with acute coronary syndrome (ACS). Comparative effectiveness between clopidogrel, prasugrel, and ticagrelor remains unclear in real-world settings.
AIMS: The objective was to evaluate one-year clinical outcomes in ACS patients treated with clopidogrel, prasugrel, or ticagrelor using data from the Polish Registry of Acute Coronary Syndromes (PL-ACS).
MATERIAL AND METHODS: This retrospective cohort study analyzed 381 278 ACS patients from the PL-ACS registry from 2009 to 2022, who were treated with clopidogrel, prasugrel, or ticagrelor during hospitalization with a 12-month consistent regimen. The primary outcome was one-year …
Por La Independencia De Las Escuelas De Negocios, James A. F. Stoner
Por La Independencia De Las Escuelas De Negocios, James A. F. Stoner
Journal of Management for Global Sustainability
No abstract provided.
Comparing The Mechanical Properties Of Conventional, Milled, And 3d-Printed Occlusal Splint Materials: An In Vitro Study, Sadeem Alzaghran
Comparing The Mechanical Properties Of Conventional, Milled, And 3d-Printed Occlusal Splint Materials: An In Vitro Study, Sadeem Alzaghran
Master's Theses (2009 -)
Aim: Evidence on the mechanical properties of digitally manufactured occlusal splint materials remains scarce. The aim of this study was to evaluate and compare the mechanical properties of CAD/CAM fabricated occlusal splint materials versus conventionally heat-cured acrylic resin materials. Materials and Methods: A total of 100 specimens were manufactured for the present study. One CAD-CAM milled (ProArt CAD Splint), one heat-polymerized (SR IVOcap Clear), and three 3D-Printed (KeySplint Hard, NightGuard Firm2 and RoDIN Splint 2.0) resin materials were evaluated. Flexural strength, flexural modulus and surface hardness were measured. The three-point flexure test was used for the determination of flexural strength …
Illness Severity And Marital Communication In Young Couples: The Moderating Role Of Marital Satisfaction, Jaime Lea Dick
Illness Severity And Marital Communication In Young Couples: The Moderating Role Of Marital Satisfaction, Jaime Lea Dick
Theses and Dissertations
The emergence of a chronic physical illness is unexpected in emerging adulthood and is accompanied by stress. Additionally, married partners of individuals with physical illnesses are likewise affected by the new diagnosis. Marriage outcomes of couples facing chronic illnesses together vary, being sometimes positive and sometimes negative. The current study examined the relationship between the emergence of chronic physical illness in emerging adults and marital communication of both the patient and partner, with marital satisfaction as a moderator. Gender differences are also addressed. From the Couple Relationships and Transition Experiences (CREATE) study, a nationally representative dataset of newly married emerging …
Multiple Stressors Effects On The Physiological Performance Of Mytilus Trossulus, M. Christina Vasquez, Alana J. Borer, Claribel Y. Alcantar, Osiris Guinea Zepeda, Camya A. Brazil, Colin Carr, Emma Guerrini Romano, Alexander J. Provenzano, Min Jeon Roh
Multiple Stressors Effects On The Physiological Performance Of Mytilus Trossulus, M. Christina Vasquez, Alana J. Borer, Claribel Y. Alcantar, Osiris Guinea Zepeda, Camya A. Brazil, Colin Carr, Emma Guerrini Romano, Alexander J. Provenzano, Min Jeon Roh
Biology Faculty Works
Mytilus galloprovincialis and M. trossulus co-occur and hybridize along set biogeographical ranges of temperature and salinity along the Pacific coast, USA. However, the role of physiological traits in mussel distribution remains poorly understood. We investigated metabolic rate, antioxidant activity (superoxide dismutase, catalase), oxidative damage (malondialdehyde content, MDA), and clearance rate of M. trossulus under multiple stressors: 7 days of hyposalinity (20, 28, 34 ppt), followed by an acute heat shock (17, 20, 25 ◦C). We found a significant effect of temperature on metabolic rate, an interaction effect on antioxidant activity, and MDA, and independent temperature and salinity effects on clearance …
Microrna Signatures In Dental Pulp Stem Cells Following Nicotine Exposure, David Vang, Leyla T. Hardin, Nabil Abid, Der Thor, Nan Xiao
Microrna Signatures In Dental Pulp Stem Cells Following Nicotine Exposure, David Vang, Leyla T. Hardin, Nabil Abid, Der Thor, Nan Xiao
Pacific Faculty Work
Background and Objectives: Nicotine is the most well-studied toxic substance in cigarette smoke and e-cigarette vape. However, smoke and vape are composed of other components that have a negative impact on health. The objective of this study is to investigate whether nicotine has a distinctive impact on molecular mechanisms in stem cells. Methods: The cellular impact of nicotine on the regenerative capacity of human dental pulp stem cells (DPSCs) and the microRNA (miRNA) profile was examined. Bioinformatic analysis was performed to identify miRNA-regulated cellular pathways associated with nicotine exposure. These pathways were then compared to those induced by cigarette smoke …
Teaching In Authentic Ways: Exhibit Work And Student Curators In Special Collections, Rebecca Fitzsimmons
Teaching In Authentic Ways: Exhibit Work And Student Curators In Special Collections, Rebecca Fitzsimmons
Faculty and Staff Publications – Milner Library
Engaging students in exhibit work offers them a chance to learn new skills and grow as scholars while producing a tangible and public-facing project outcome from their coursework. From learning to communicate complex ideas to making research connections between rare and primary sources, exhibit curation relies on building research skills, sharpening writing and communication techniques, and developing critical thinking skills. Pushing and refining ideas is an essential part of the iterative process of research, and exhibit curation invites students to learn this practice in a real-world, project-based way. More specifically, it requires students to read, review, compare, and analyze more …
Dynamic Sparsification In Secure Gradient Aggregation For Federated Learning, Bikash Samanta
Dynamic Sparsification In Secure Gradient Aggregation For Federated Learning, Bikash Samanta
Master’s Dissertations
Secure aggregation is a critical component of privacy-preserving federated learning. However, existing fixed-sparsity approaches often incur unnecessary communication overhead. We present DynamicSecAgg, a novel framework that introduces dynamic sparsity while preserving coordinate-level privacy. Our method achieves significant improvements in communication efficiency while maintaining — and in some cases improving — model accuracy across both IID and non-IID user distributions. The framework maintains information-theoretic privacy guarantees via adaptive gradient thresholding and polynomial-based aggregation, proving particularly effective under heterogeneous data settings. These results establish dynamic sparsity as a key optimization for efficient and privacy-preserving federated learning.
Cloud-Assisted Multi-Channel Data Broadcasting, Debabrata Maji
Cloud-Assisted Multi-Channel Data Broadcasting, Debabrata Maji
Master’s Dissertations
The convergence of Internet of Things (IoT) and cloud computing has transformed technology, impacting commerce, industrial production, data management, etc. Multi- Channel Broadcast Encryption (MCBE), first introduced by Phan et al. (ASIACCS 2013), is a cryptographic encryption primitive used for both IoT and Cloud that permits a sender to e!ciently and securely encrypt several messages for di”erent groups of receivers. After thoroughly exploring the existing literature, we observe that none achieves the robust provable security within the standard model. This paper addresses this gap, aiming to achieve adaptive INDistinguishable under full-IDentity Chosen-Ciphertext Attack (IND-ID-CCA) security by constructing an e!cient identity-based …
Adolescents' Use Of Music For Pain Management., Rebecca J. Lepping, Lora L. Black, Kymberly A. Kline, Deanna Hanson-Abromeit, Andrea L. Chadwick, Dustin Wallace, William R. Black
Adolescents' Use Of Music For Pain Management., Rebecca J. Lepping, Lora L. Black, Kymberly A. Kline, Deanna Hanson-Abromeit, Andrea L. Chadwick, Dustin Wallace, William R. Black
Manuscripts, Articles, Book Chapters and Other Papers
To investigate the experiences of adolescents with chronic pain who participated in an intensive interdisciplinary pain treatment program, this secondary study analyzes the themes that emerged regarding the spontaneous utilization of music in coping strategies for chronic pain. During research interviews focused on coping skills and treatment engagement, participants spontaneously reported using music as an effective coping strategy for managing pain. A deductive thematic analysis revealed key themes related to their usage, including using music as a distractor, motivator and in other ways as coping strategies. Since participants indicated that music is essential to their experiences of coping with pain, …
Infectious Scleritis: A Comprehensive Narrative Review Of Epidemiology, Clinical Characteristics, And Management Strategies, Hamidreza Ghanbari, Masoud Rahimi, Ali Momeni, Kiana Hassanpour, Nikoo Bayan, Karen E. Lee, Alex Hansen, Ali R. Djalilian, Christopher J. Rapuano, Mohammad Soleimani
Infectious Scleritis: A Comprehensive Narrative Review Of Epidemiology, Clinical Characteristics, And Management Strategies, Hamidreza Ghanbari, Masoud Rahimi, Ali Momeni, Kiana Hassanpour, Nikoo Bayan, Karen E. Lee, Alex Hansen, Ali R. Djalilian, Christopher J. Rapuano, Mohammad Soleimani
Wills Eye Hospital Papers
This study aims to provide an update on infectious scleritis (IS). A comprehensive search was conducted using Google Scholar, Scopus, and PubMed. IS is a rare but critical condition that presents significant diagnostic challenges and often leads to poor visual outcomes. It accounts for approximately 5%-10% of scleritis cases and warrants significant attention due to its delayed diagnosis. Ocular surgery is the primary contributor to IS, accounting for a substantial proportion of cases ranging from 58% to 83%, followed by trauma contributing to approximately 10% of cases. IS can be caused by various microorganisms, including bacteria (86%-87%), fungi (11%-13%), viruses, …
Closing The Gap In A Global Space Weather Monitoring System, Rebecca Irelan
Closing The Gap In A Global Space Weather Monitoring System, Rebecca Irelan
UNH Today Archive
No abstract provided.
Constitutive Il-7 Signaling Promotes Car-Nk Cell Survival In The Solid Tumor Microenvironment But Impairs Tumor Control, Matthew Dysthe, Ishwar Navin, Dayenne Van Leeuwen, Josue Pineda, Corrine Baumgartner, Cliona M Rooney, Robin Parihar
Constitutive Il-7 Signaling Promotes Car-Nk Cell Survival In The Solid Tumor Microenvironment But Impairs Tumor Control, Matthew Dysthe, Ishwar Navin, Dayenne Van Leeuwen, Josue Pineda, Corrine Baumgartner, Cliona M Rooney, Robin Parihar
Faculty, Staff and Students Publications
Background: Adoptive transfer of chimeric antigen receptor (CAR)-expressing natural killer (NK) cells has demonstrated success against hematological malignancies. Efficacy against solid tumors has been limited by poor NK cell survival and function in the suppressive tumor microenvironment (TME). To enhance efficacy against solid tumors, stimulatory cytokines have been incorporated into CAR-NK cell therapeutic approaches. However, current cytokine strategies have limitations, including systemic toxicities, exogenous dependencies, and unwanted TME bystander effects. Here, we aimed to overcome these limitations by modifying CAR-NK cells to express a constitutively active interleukin (IL)-7 receptor, termed C7R, capable of providing intrinsic CAR-NK cell activation that does …
Understanding The Health And Social Determinants Of Health Needs Of Resettled Afghan Refugees In Houston, Texas, Karissa Chesky, Angelica Garcia, Aaron Pathak, Imran Humza Hanif, Srijana Shrestha, Sophia Banu