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Articles 155971 - 156000 of 5150686
Full-Text Articles in Entire DC Network
Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Unreclaimed Sites Ur-22 Site Evaluation Summary Report (Dated April 2, 2025), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Table Of Contents, The Editors
Key Technologies And Approaches For Water Resource Conservation And Utilization In Arid To Semi-Arid Open-Pit Coal Mining Areas In The Northern Sand Prevention Belt Of China, Fang Jie, Xu Zhimin, Cheng Wei, Lu Zihan, Zhao Yongqiang, Zhu Yuhao, Chen Tianci
Key Technologies And Approaches For Water Resource Conservation And Utilization In Arid To Semi-Arid Open-Pit Coal Mining Areas In The Northern Sand Prevention Belt Of China, Fang Jie, Xu Zhimin, Cheng Wei, Lu Zihan, Zhao Yongqiang, Zhu Yuhao, Chen Tianci
Coal Geology & Exploration
Background The northern sand prevention belt (NSPB) of China is primarily distributed in arid and semi-arid regions such as Xinjiang, Inner Mongolia, Ningxia, and Gansu. This belt exhibits scarce rainfall and intense evaporation, which lead to a shortage of water resources and vulnerable ecosystems. In recent years, the large-scale development of open-pit coal mines has caused increasingly violent mining disturbance in this belt, as well as increasingly prominent issues such as a decline in regional groundwater levels and ecological contradictions. To address technical challenges in balancing coal exploitation and water resource conservation in this belt, there is an urgent need …
Trace Element Migration In Groundwater In Sandstone Aquifers In The Jurassic Coalfields: A Case Study Of The Guojiahe Coal Mine, Shi Longqing, Qu Xingyue, Cheng Hao
Trace Element Migration In Groundwater In Sandstone Aquifers In The Jurassic Coalfields: A Case Study Of The Guojiahe Coal Mine, Shi Longqing, Qu Xingyue, Cheng Hao
Coal Geology & Exploration
Background The Ordos Basin, a vital energy hub in China, contains considerable coal reserves. However, the environmental issues arising from coal mining warrant attention, especially given the fragile ecosystems of the Jurassic coalfields. Methods This study investigated the Guojiahe Coal Mine in Shaanxi Province. Based on measured concentrations of 31 trace elements dissolved in sandstone aquifers across varying geological ages, this study conducted a comparative analysis of the evolutionary characteristics of these trace elements between unmined reducing and post-mining oxidizing conditions using numerical simulations. Accordingly, it revealed the impacts of coal seam mining on trace element migration in groundwater in …
Seismic Anisotropy Of Sandstone Aquifers In Coal Seam Roofs, Yu Hang, Chen Tongjun
Seismic Anisotropy Of Sandstone Aquifers In Coal Seam Roofs, Yu Hang, Chen Tongjun
Coal Geology & Exploration
Objective The identification and assessment of sandstone aquifers in coal seam roofs play a vital role in the safe mining of mines. Investigating the rock physics and amplitude variation with incidence and azimuth (AVAz) responses of these sandstone aquifers is critical to the prevention and control of water hazards in mines. Methods By integrating rock physical models Voigt-Reuss-Hill (VRH), differential equivalent medium (DEM), Hudson, and Wood, as well as Gassmann’s anisotropic fluid substitution theory, this study proposed a rock physics modeling method for fractured sandstones of the horizontal transversely isotropic (HTI) media type (hereafter referred to as HTI sandstones). Using …
Research On Monitoring And Early Warning Systems For Mine Water: Progress And Prospects, Yin Shangxian, Ding Yingying, Lian Huiqing, Dong Donglin, Du Tong, Yin Huichao, Zhao Peng, Zhang Yi’An, Wang Xiong
Research On Monitoring And Early Warning Systems For Mine Water: Progress And Prospects, Yin Shangxian, Ding Yingying, Lian Huiqing, Dong Donglin, Du Tong, Yin Huichao, Zhao Peng, Zhang Yi’An, Wang Xiong
Coal Geology & Exploration
Background Water disasters in mines are occasional accidents occurring due to the influence or triggered by mining-induced intense changes in geological bodies. The complexity, heterogeneity, and dynamics of geological bodies, coupled with the random and instantaneous nature of mining influence, lead to the uncertainty, instability, occasionality, and transience of water disasters in mines. Given that mine water monitoring and early warning serve as a prerequisite for advanced disaster prevention and control, their research and system construction hold great theoretical significance and practical value. Progress and Prospects Fighting against water disasters in mines is conducted throughout the development and utilization of …
Experiments On The Diffusion Patterns Of Coal Gangue-Based Grout In Goaves Under Varying Rock Particle Sizes And Grout Mass Fractions, Zeng Yifan, Yuan Zilong, Li Hao, Wu Qiang, Zhao Gangyi, Zhou Anqi, Gao Xiang, Zhang Shuai, Bai Yanfei, Liang Jin, Yang Huxiong, Sheng Xinli, Yang Donghui, Zhao Yixia
Experiments On The Diffusion Patterns Of Coal Gangue-Based Grout In Goaves Under Varying Rock Particle Sizes And Grout Mass Fractions, Zeng Yifan, Yuan Zilong, Li Hao, Wu Qiang, Zhao Gangyi, Zhou Anqi, Gao Xiang, Zhang Shuai, Bai Yanfei, Liang Jin, Yang Huxiong, Sheng Xinli, Yang Donghui, Zhao Yixia
Coal Geology & Exploration
Objective Investigating grout diffusion patterns and predicting the grouting range hold great significance for coal gangue grouting and filling engineering in goaves. Specifically, they are significant for designing grouting hole and row spacing, guiding grouting construction, determining the grouting filling degree, and further ensuring grouting effects. Methods Using crushed rocks as the medium to be grouted and coal gangue-based grout as the grouting materials, this study conducted grouting experiments under different particle sizes of crushed rocks and varying mass fractions of grout. Accordingly, it investigated the flow patterns of gangue-based grout in goaves. Results and Discussion Under a mass fraction …
Differential Roof Water Hazards And Comprehensive Utilization Of Mine Water In The Dongsheng Coalfield, Huang Haiyu, Ding Xiang, Liu Xi, Fan Jiangwei, Ji Zhuochen, Li Zhaoyang
Differential Roof Water Hazards And Comprehensive Utilization Of Mine Water In The Dongsheng Coalfield, Huang Haiyu, Ding Xiang, Liu Xi, Fan Jiangwei, Ji Zhuochen, Li Zhaoyang
Coal Geology & Exploration
Objective The Dongsheng coalfield exhibits various types of mine water hazards, complex water filling mechanisms, and high water inflow with high total dissolved solids (TDS) content in mining areas. These characteristics pose challenges to the comprehensive utilization of mine water, severely restricting the safe, green, and efficient coal mining in the coalfield. Methods This study aims to reveal the roof water filling characteristics of the Dongsheng coalfield and enhance the comprehensive utilization of mine water. Using methods including statistical analysis of drilling data, analytic hierarchy process, and hydrochemical tests, this study analyzed the strata, spatial distribution of aquifers, and the …
Mechanisms Behind Grouting Pressure Jumping In Low-Permeability Limestones And Techniques For Grouting Pressure Control, Fan Zhenli, Cao Lutong, Cui Yong, Zhang Zhiwei, Zhang Fengda
Mechanisms Behind Grouting Pressure Jumping In Low-Permeability Limestones And Techniques For Grouting Pressure Control, Fan Zhenli, Cao Lutong, Cui Yong, Zhang Zhiwei, Zhang Fengda
Coal Geology & Exploration
Background The exploitation of the Carboniferous-Permian coalfields in China is gradually transitioning toward coal seams in lower formations. In this context, issues including the confined water hazards in the floor and karst water preservation become increasingly pronounced. During the advanced surface treatment of karst water hazards in coal seam floors, the unclear patterns of matching between grout selection and grouting pressure control lead to empirical parameter selection, thereby yielding poor performance of grouting reinforcement. Methods This study aims to deal with the phenomena of rapid pressure rise with a limited grout volume in the low-permeability argillaceous limestones within the top …
Suitability Evaluation For Deep Geological Storage Of Mine Water In The Ordos Basin, Gulbostan Tursun, Sui Wanghua, Aibibai Mamat, Yang Weifeng, Chen Ge, Gao Liang
Suitability Evaluation For Deep Geological Storage Of Mine Water In The Ordos Basin, Gulbostan Tursun, Sui Wanghua, Aibibai Mamat, Yang Weifeng, Chen Ge, Gao Liang
Coal Geology & Exploration
Objective Given the issues of large mine water drainage in coal mines in China, as well as the corresponding high treatment cost and low utilization rate, thoroughly investigating efficient, environmentally friendly, economically feasible mine water treatment technologies is the key to the green transformation and the implementation of the sustainable development strategy in the coal industry. Deep geological storage of mine water represents an emerging technology for mine water treatment, enjoying the advantages of low cost and zero emissions. A key step in the application of this technology is to select suitable target reservoirs. Although relevant studies have proposed some …
Advances In Key Technologies For The Management, Restoration, Development, And Utilization Of Coal Mining Subsidence Areas, Meng Zhuanghan, Wang Yutao, Tian Yanzhe
Advances In Key Technologies For The Management, Restoration, Development, And Utilization Of Coal Mining Subsidence Areas, Meng Zhuanghan, Wang Yutao, Tian Yanzhe
Coal Geology & Exploration
Background Coal mining subsidence areas, formed by the exploitation of coal resources, have emerged as severe challenges to the construction of ecological civilization and the sustainable development of the social economy in China. Their management, restoration, development, and utilization play a significant role in ecological security, food security, and energy transformation. Methods This study aims to address the unresolved and emerging issues in the management of coal mining subsidence areas. Based on the core concepts of management, restoration, development, and utilization, this study developed a dual-level zoning basis system combining theories and reality. Accordingly, coal mining subsidence areas in China …
Enhancing Feature Selection In Network Intrusion Detection Systems Using A Novel Hybrid Binary Swarm Algorithms, Maher Khalaf Hussein, Asmaa Alqassab, Lubna Thanoon Alkahla
Enhancing Feature Selection In Network Intrusion Detection Systems Using A Novel Hybrid Binary Swarm Algorithms, Maher Khalaf Hussein, Asmaa Alqassab, Lubna Thanoon Alkahla
Baghdad Science Journal
An intrusion detection system (IDS) is a system that monitors network traffic for any mistrustful activity and issues alerts when it is detected. The selection of feature stage is important in effective intrusion detection systems, as it determines the features that are most influential in detecting normal traffic and malicious traffic. In this study, new proposed hybrid method for selecting features in intrusion detection systems based on the hybrid binary Salp Swarm algorithm (SSA) and the binary Pigeon Inspired Optimizer (PIO), inspired by the collective behavior of animals. The proposed method removes unnecessary features and increases the number of features …
Performance Of Cnn And Lstm Model On Covid-19 News Headline Data Classification, Dian Kurniasari, Luthfia Nur Azizah, Purnomo Husnul Khotimah, Warsono
Performance Of Cnn And Lstm Model On Covid-19 News Headline Data Classification, Dian Kurniasari, Luthfia Nur Azizah, Purnomo Husnul Khotimah, Warsono
Baghdad Science Journal
During the COVID-19 pandemic, mass media, especially online news portals, have been essential in disseminating health information and governmental policies, serving as the primary reference for the general public. Unfortunately, not all news articles are relevant to COVID-19 case monitoring. Some sources provide information that is less useful for tracking the pandemic's progression. Thus, it is crucial to develop a methodology that allows news articles to effectively aid stakeholders in monitoring COVID-19 developments. This study proposes using Deep Learning (DL) models to classify news headlines for this purpose. The aim is to identify suitable and reliable DL models for classifying …
Genetic Control Of Sweetness And Acidity In Blackberry, Carly Godwin, T. Mason Chizk, Carmen John, Lacy Nelson, Renee Threlfall, John R. Clark, Margaret L. Worthington
Genetic Control Of Sweetness And Acidity In Blackberry, Carly Godwin, T. Mason Chizk, Carmen John, Lacy Nelson, Renee Threlfall, John R. Clark, Margaret L. Worthington
Horticulture Faculty Publications and Presentations
Introduction The global blackberry (Rubus subgenus Rubus) industry has experienced rapid growth during the past 20 years. Even so, many industry stakeholders report complaints from consumers and grocers stating that blackberries are often too tart or not sweet enough for their palate. Studies have shown that most consumers prefer sweet blackberries with relatively low acidity, but little research has been conducted to understand the genetic control of these traits in Rubus.Methods The objective of this study was to identify quantitative trait loci (QTL) related to sweetness and acidity in autotetraploid blackberry using a genome-wide association study (GWAS). A panel consisting …
Adhd In Youth With Major Depressive Disorder In The Texas Youth Depression And Suicide Research Network (Tx-Ydsrn): Clinical Correlates And Moderators, Blake M Upshaw, Samuel D Spencer, Caitlin M Pinciotti, Vadym Zhyrov, Abu Minhajuddin, Ace A Castillo, Allyssa Abacan, Holli Slater, Rachel A Walker, Joseph C Blader, Sarah L Martin, Jeffrey D Shahidullah, Jair C Soares, Robert Andrew Harper, Madelyn Guerra, Lynnel C Goodman, Wayne K Goodman, Sarah M Wakefield, Madhukar H Trivedi, Eric A Storch
Adhd In Youth With Major Depressive Disorder In The Texas Youth Depression And Suicide Research Network (Tx-Ydsrn): Clinical Correlates And Moderators, Blake M Upshaw, Samuel D Spencer, Caitlin M Pinciotti, Vadym Zhyrov, Abu Minhajuddin, Ace A Castillo, Allyssa Abacan, Holli Slater, Rachel A Walker, Joseph C Blader, Sarah L Martin, Jeffrey D Shahidullah, Jair C Soares, Robert Andrew Harper, Madelyn Guerra, Lynnel C Goodman, Wayne K Goodman, Sarah M Wakefield, Madhukar H Trivedi, Eric A Storch
Faculty, Staff and Student Publications
Objective: Depression is a major public health concern with a 19% lifetime prevalence in youth, often precipitating other concerns, including suicidal behavior, poor school performance, and worsened peer relationships. ADHD is also common among youth and frequently presents alongside major depressive disorder (MDD), with this comorbidity associated with increased impairment. More research is needed to elucidate the clinical characteristics of this comorbidity (MDD + ADHD), especially as it relates to youth with MDD and no ADHD (MDD - ADHD). The present study examined the clinical correlates of MDD + ADHD in youth and the presence of an ADHD diagnosis as …
Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2022 Unreclaimed Sites Sampling: Ur-06 Site Evaluation Summary Report (Dated April 1, 2025), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Re: Comment Letter For Bpsou Uncontrolled Surface Flow Areas Drainage C 30% Design Rawp (Dated June 23, 2025), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2025 Residential Metals Abatement Program (Rmap) Valley Sand & Gravel (Builders Firstsource) Borrow Submittal #1 (Dated June 27, 2025), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Pre-Service Teachers’ Perceptions Of Creativity In Education, Merve Topak-Jamsran
Pre-Service Teachers’ Perceptions Of Creativity In Education, Merve Topak-Jamsran
Theses and Dissertations
This study examined the relationship between pre-service teachers’ self-reported creativity and their appreciation for students’ creative characteristics. The researcher replicated Kettler et al.'s (2018) "Teacher Perceptions of Creativity in the Classroom" study of in-service teachers. Specifically, the relationship among pre-service teachers’ creative self-efficacy, self-reported personal creativity, perceived importance of promoting creativity, and their preference for student characteristics in the classroom was investigated. Data were gathered using a web-based questionnaire e-mailed to pre-service teachers in educational preparation programs in a southern U.S. state. The study sample were 92 pre-service teachers who had completed at least one practicum or who were currently …
Microalgal Biorefineries In Sustainable Biofuel Production And Other High-Value Products, Swapnamoy Dutta, Sampriti Kataki, Ishita Banerjee, Cheryl Bernice Pohrmen, Krishna Kumar Jaiswal, Amit K. Jaiswal
Microalgal Biorefineries In Sustainable Biofuel Production And Other High-Value Products, Swapnamoy Dutta, Sampriti Kataki, Ishita Banerjee, Cheryl Bernice Pohrmen, Krishna Kumar Jaiswal, Amit K. Jaiswal
Research Outputs: 2025-Present
Microalgae has been emerging as a promising solution against the backdrop of the global need for sustainable, eco-friendly alternatives. This review article analyses the use of photosynthetic microalgae as an important resource for sustainable biofuel and high value bioproduct production, emphasizing the potential of self-sustaining microalgae biorefineries. A closed-loop, integrated multi-product producing microalgal biorefinery approach could significantly reduce the indicated negative environmental and energy impact from standalone microalgal biofuel generation. The economic feasibility of these biorefineries is linked to their recovery rate, improved by integrating various unit operations as well as multiple product dimensions under optimal conditions, enhancing resource recovery, …
Speed Endurance Training Using Artificial Intelligence Techniques (Polar H10) And Its Effect On Selected Components Of Physical Fitness And Tactical Behavior, Akram Hussein Jabir Al-Janabi, Mustafa Jasim
Speed Endurance Training Using Artificial Intelligence Techniques (Polar H10) And Its Effect On Selected Components Of Physical Fitness And Tactical Behavior, Akram Hussein Jabir Al-Janabi, Mustafa Jasim
Modern Sport
The regulation of training loads, particularly for speed endurance, is crucial for optimizing physical fitness in football players. This is achieved by balancing external load components such as intensity, volume, and rest with internal load, as measured by heart rate. Such regulation has a precise impact on the level of specific physical fitness. This study focuses on the regulation of speed endurance training during the specialized preparation period, using artificial intelligence to assess its effects on selected physical fitness components and tactical behaviour in football players. The study utilizes Polar H10 sensors, which function effectively under various environmental conditions and …
Twist And Snout: Head And Body Morphologies Determine Feeding Kinematics In Substrate-Biting Fishes, Tal Perevolotsky, Jacob M. Brotman-Krass, Yarden Ratner, Yael Avigad, Adam P. Summers, Cassandra M. Donatelli, Roi Holzman
Twist And Snout: Head And Body Morphologies Determine Feeding Kinematics In Substrate-Biting Fishes, Tal Perevolotsky, Jacob M. Brotman-Krass, Yarden Ratner, Yael Avigad, Adam P. Summers, Cassandra M. Donatelli, Roi Holzman
Engineering Faculty Articles and Research
Synopsis
Across teleosts, feeding by biting substrate-attached prey has evolved multiple times and is associated with convergent morphologies that include a deep body and an elongated, tapered head. However, the functional role of these morphologies in substrate-biting fish is not established. Here, we tested the hypothesis that these morphologies function as control surfaces that affect feeding kinematics during biting. To test this hypothesis, we used simplified physical models of substrate-biting reef fish and examined the role of head, body, and fin morphology in determining feeding kinematics that facilitate the removal of substrate-attached prey. Models simulated the swift lateral movement of …
Relationship Of A Business Simulation Course To Act Applied Math Outcomes, Brenda Lorraine Savage
Relationship Of A Business Simulation Course To Act Applied Math Outcomes, Brenda Lorraine Savage
Walden Dissertations and Doctoral Studies
Little evidence links the use of business simulations to advances in the higher order thinking skills that high school students need to prepare for careers in finance. The problem for this study was that students in three southern high schools had limited success on the ACT Applied Math Assessment, and there was a need to explore the relationship of a newly implemented stock market trading simulation course to student success on the assessment. Kolb’s experiential learning theory, which was aligned to the simulation activities, guided the study. The purpose of this quantitative predictive study was to determine whether participation in …
Attitudes Toward Seeking Mental Health Services Among Young African American Same-Sex-Oriented Men, Anthony Earl Fox
Attitudes Toward Seeking Mental Health Services Among Young African American Same-Sex-Oriented Men, Anthony Earl Fox
Walden Dissertations and Doctoral Studies
In 2018 suicide was the second leading cause of death for young people between the ages of 15 and 24 (CDC, 2018). Suicide and other factors like HIV, depression, and oppression may serve as barriers to seeking counseling among African American same-sex-oriented men ages 18-26. Due to a previous gap in the literature regarding barriers to seeking counseling, this study may support counselors in finding ways to address the disparity in counseling utilization among this population. Grounded in queer and social identity theories, the purpose of this quantitative study was to examine if adverse childhood experiences, current civic unrest, HIV, …
Towards Scalable Taxi Demand Prediction, Yifei Shen
Towards Scalable Taxi Demand Prediction, Yifei Shen
Lingnan Theses (MPhil & PhD)
Accurate taxi demand prediction is essential for optimizing urban mobility systems across varying spatial-temporal resolutions and data conditions. Scalable taxi demand prediction refers to the capability of forecasting models to adapt to different granularities of spatial and temporal data while maintaining prediction accuracy, a critical requirement for practical urban applications ranging from fleet management to transportation planning. However, two fundamental challenges impede this scalability: data sparsity and multi-resolution forecasting requirements. Data sparsity, particularly pronounced in high-resolution predictions where numerous regions exhibit minimal activity, significantly compromises model performance. Concurrently, different urban applications necessitate predictions at varying temporal and spatial granularities, requiring …
Inhibition Of The Caveolin-1 Pathway Promotes Apoptosis And Overcomes Pan-Tyrosine Kinase Inhibitor Resistance In Hepatocellular Carcinoma, Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips, Andrew D. Redfern, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey Mccaughan, Peter Leedman
Inhibition Of The Caveolin-1 Pathway Promotes Apoptosis And Overcomes Pan-Tyrosine Kinase Inhibitor Resistance In Hepatocellular Carcinoma, Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips, Andrew D. Redfern, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey Mccaughan, Peter Leedman
Research outputs 2022 to 2026
Resistance to multi-tyrosine kinase inhibitors (TKI) is a major clinical concern in advanced hepatocellular carcinoma (HCC). Herein, we aimed to uncover the mechanisms underlying pan-TKI resistance and to identify potential therapeutic targets. We used multiple TKI-resistant HCC cell lines to identify caveolin-1 (CAV1) as a key driver of therapeutic resistance. CAV1 downregulation induced apoptosis, inhibited metastasis and restored TKI sensitivity in both inherent and acquired TKI-resistant HCC cells. Mechanistically, in acquired TKI-resistant cells aberrant CAV1/STAT3/P70S6K signalling is required for their survival, motility, and invasiveness. CAV1 inhibition reduced expression of dormancy regulators E-cadherin, RAC1 and p21, enhanced cancer stemness markers, and …
The Impact Of Teaching Multiple Responses On Resurgence Of Target Behavior And Persistence Of Alternative Responding., Brittany H. Loder-Lafferty, Amanda N. Zangrillo, Alexandra M. Cicero, Cynthia P. Livingston, Jessica P. Tran, Mark Connelly
The Impact Of Teaching Multiple Responses On Resurgence Of Target Behavior And Persistence Of Alternative Responding., Brittany H. Loder-Lafferty, Amanda N. Zangrillo, Alexandra M. Cicero, Cynthia P. Livingston, Jessica P. Tran, Mark Connelly
Manuscripts, Articles, Book Chapters and Other Papers
This study evaluated the effects of teaching multiple alternative responses on the resurgence of a target response and the persistence of an alternative response in an applied setting. Using a between-participants design, we examined how teaching multiple alternative responses impacted resurgence and persistence upon exposure to extinction. Additionally, we investigated the role of preference in response allocation and shifts in participant preference following extinction. Results indicated resurgence across both conditions, with no consistent difference in severity between single and multiple alternative response conditions. However, within-session analyses revealed greater persistence of the alternative response for participants taught multiple alternative responses, suggesting …
U-Rich Elements Drive Pervasive Cryptic Splicing In 3' Utr Massively Parallel Reporter Assays, Khoa Dao, Courtney F Jungers, Sergej Djuranovic, Anthony M Mustoe
U-Rich Elements Drive Pervasive Cryptic Splicing In 3' Utr Massively Parallel Reporter Assays, Khoa Dao, Courtney F Jungers, Sergej Djuranovic, Anthony M Mustoe
2020-Current year OA Pubs
Untranslated RNA sequences play essential roles in orchestrating gene expression. However, the sequence codes and mechanisms underpinning post-transcriptional regulation remain incompletely understood. Here, we revisit the finding from a prior massively parallel reporter assay (MPRA) that AU-rich elements in 3' untranslated regions (3' UTRs) can drive upregulation or downregulation of mRNA expression depending on 3' UTR context. We unexpectedly discover that this variable regulation arises from widespread cryptic splicing, predominately from an unannotated splice donor in the coding sequence of GFP to diverse acceptor sites in reporter 3' UTRs. Splicing is activated by U-rich sequences, which function as potent position-dependent …
Phase 1b/2 Study Evaluating Safety, Efficacy And Immune Effects Of Tlr9 Agonist Cavrotolimod With Anti-Pd-1 Antibodies Among Patients With Advanced Solid Tumors, Mohammed M Milhem, George Ansstas, Et Al.
Phase 1b/2 Study Evaluating Safety, Efficacy And Immune Effects Of Tlr9 Agonist Cavrotolimod With Anti-Pd-1 Antibodies Among Patients With Advanced Solid Tumors, Mohammed M Milhem, George Ansstas, Et Al.
2020-Current year OA Pubs
BACKGROUND: There is an unmet need for novel immunotherapies to overcome immune evasion in patients with advanced skin cancers resistant to programmed death (PD)-1 / PD-ligand 1 (PD-L1) blockade. Cavrotolimod is a novel spherical nucleic acid configuration of a toll-like receptor 9 agonist oligonucleotide, designed to trigger innate and adaptive immune responses to tumors.
PATIENTS AND METHODS: The safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of intratumoral cavrotolimod, first dosed alone and then in combination with anti-PD-1 antibodies (pembrolizumab or cemiplimab), were assessed in a combined Phase 1b/2 dose escalation/dose expansion study in patients with advanced skin cancers, including melanoma, Merkel …
Replication Of Sensor-Based Categorization Of Upper-Limb Performance In Daily Life In People Post Stroke And Generalizability To Other Populations, Chelsea E Macpherson, Marghuretta D Bland, Christine Gordon, Allison E Miller, Caitlin Newman, Carey L Holleran, Christopher J Dy, Lindsay Peterson, Keith R Lohse, Catherine E Lang
Replication Of Sensor-Based Categorization Of Upper-Limb Performance In Daily Life In People Post Stroke And Generalizability To Other Populations, Chelsea E Macpherson, Marghuretta D Bland, Christine Gordon, Allison E Miller, Caitlin Newman, Carey L Holleran, Christopher J Dy, Lindsay Peterson, Keith R Lohse, Catherine E Lang
2020-Current year OA Pubs
BACKGROUND: Wearable movement sensors can measure upper limb (UL) activity, but single variables may not capture the full picture. This study aimed to replicate prior work identifying five multivariate categories of UL activity performance in people with stroke and controls and expand those findings to other UL conditions.
METHODS: Demographic, self-report, and wearable sensor-based UL activity performance variables were collected from 324 participants (stroke
RESULTS: Two PCs explained 70-90% variance: PC1 (overall UL activity performance) and PC2 (preferred-limb use). A five-variable, five-cluster model was optimal across samples. In comparison to clusters, two PCs and individual accelerometry variables showed higher convergent …