Digital Commons Network^™

Targeting Wnt-Driven Metabolic Adaptations In Cancer: Integrating Glycolysis, Glutaminolysis, Ido1-Mediated Immune Evasion, And Therapeutic Delivery Strategies, Eric Flores-Hernández, Grace Binder, Kuo-Ching Mei, Nydia Tejeda-Muñoz

Pharmacy Faculty Scholarship

The Wnt pathway is an evolutionarily conserved signaling cascade that regulates a wide range of fundamental cellular processes, including proliferation, differentiation, polarity, migration, metabolism, and survival. Due to its central regulatory roles, Wnt signaling is critically involved in the pathophysiology of numerous human diseases. Aberrant activation or insufficient inhibition of this pathway has been causally linked to cancer, degenerative disorders, metabolic syndromes, and developmental abnormalities. Wnt signaling drives cancer progression by reprogramming metabolism and promoting immune evasion. Wnt-driven tumors exhibit enhanced aerobic glycolysis (the Warburg effect), glutaminolysis, and macropinocytosis, which support rapid proliferation and help maintain redox homeostasis under nutrient-limited …

Maya Binyam, Raymond Carver Reading Series, February 12, 2025, Maya Binyam

Raymond Carver Reading Series

A video recording of Maya Binyam reading on February 12, 2025, as part of the Syracuse University Creative Writing Program's Raymond Carver Reading Series.

Hari Kunzru, Raymond Carver Reading Series, March 19, 2025, Hari Kunzro

Raymond Carver Reading Series

A video recording of Hari Kunzro reading on February 26, 2025, as part of the Syracuse University Creative Writing Program's Raymond Carver Reading Series.

Hayan Charara, Raymond Carver Reading Series, April 2, 2025, Hayan Charara

Raymond Carver Reading Series

A video recording of Hayan Charara reading on April 2, 2025, as part of the Syracuse University Creative Writing Program's Raymond Carver Reading Series.

Claire Messud, Raymond Carver Reading Series, April 23, 2025, Claire Messud

Raymond Carver Reading Series

A video recording of Claire Messud reading on April 2, 2025, as part of the Syracuse University Creative Writing Program's Raymond Carver Reading Series.

Natalie Shapero, Raymond Carver Reading Series, January 29, 2024, Natalie Shapero

Raymond Carver Reading Series

A video recording of Natalie Shapero reading on January 29, 2025, as part of the Syracuse University Creative Writing Program's Raymond Carver Reading Series.

“Can You Hear Me?” Teacher Stories About State-Mandated Standardized Testing, Michele I. Shelton

Educational Studies Dissertations

This study strives to understand teacher perceptions as a meaningful examination of state-mandated standardized testing's impacts on students and its outcomes by asking:

How do teachers experience the impact of state-mandated standardized tests on the students as evidenced in their stories?

What are the benefits and disadvantages to the use of state-mandated standardized tests?

To what extent has state-mandated standardized tests created inequalities in the educational system?

This study utilized a Narrative Research approach with [descriptive] interpretive qualitative research. Questionnaires and interviews were analyzed using the Thematic Inductive Analysis approach. The theoretical framework was adopted from Robinson & Robinson: centering …

Widowhood, Health, And Depression: Intergenerational Relationships, Social Support, And Psychological Well-Being Among Korean Older Adults, Yooumi Lee

Dissertations - ALL

This dissertation focuses on Korean older adults and their experiences with widowhood and health issues in later life. Specifically, it examines the associations between stressful life events, such as recent widowhood and poor health, and depressive symptoms. It then further explores if intergenerational relationships and social support mediate the distressing consequences of these stressful life events. Using longitudinal data from 2006 to 2020 Korean Longitudinal Study of Aging, this study estimates residualized change Ordinary Least Squares (OLS) regression models predicting depression at Tw as a function of depression at Tw-1 and other covariates among individuals who are 60 or older …

Exploring The Mediating Role Of Autonomous Motivation Between Basic Psychological Needs And Burnout Among Counselors-In-Training, Meredith Si Snieckus

Dissertations - ALL

Burnout is a pressing concern among counselors-in-training (CITs), threatening not only their well-being but also the quality of services they provide. Guided by Self-Determination Theory (SDT; Deci & Ryan, 2000; Ryan & Deci, 2017), this study investigated the relationships among basic psychological needs satisfaction (BPNS), autonomous motivation (AM), and burnout in a national sample of CITs enrolled in Council for Accreditation of Counseling and Related Educational Programs (CACREP) accredited counseling programs. Specifically, it examined whether AM mediates the relationship between BPNS and the three dimensions of burnout, emotional exhaustion (EE), depersonalization (DP), and diminished personal accomplishment (DPA), as conceptualized by …

Government Policies Influencing The Retainment Of Civil Engineers In Guyana's Public Sector, Gracelyn George

Walden Dissertations and Doctoral Studies

The low retention of civil engineers in Guyana’s public sector has impeded the execution of needed infrastructure projects in the country. The literature reviewed highlighted that there continued to be questions regarding why people leave engineering jobs. Moreover, there was a limited understanding of what societal attributes influenced the problem, while there continued to be a growing demand for civil engineers. The literature specific to government policies influencing the retention of civil engineers in the public sector was lacking, presenting an opportunity to expand the application of the policy feedback theory, which provided a lens for examining retention measures in …

Staff Education Project To Train Charge Nurses On The Use Of The Tsam Framework To Improve Leadership Competencies, Natoya Gaye Langley

Walden Dissertations and Doctoral Studies

The purpose of this doctoral project was to improve charge nurse leadership competencies through education on the tiered skills acquisition model (TSAM), addressing challenges of high turnover, limited orientation, and compromised care quality in an inpatient psychiatric facility. The background reveals a two-year financial loss of over $1.8 million tied to staff attrition, highlighting the urgent need for a structured training framework. TSAM, a progressive, competency-based model, offers a pathway for deliberate skill acquisition, leadership growth, and enhanced role clarity. A staff education program was implemented with ten charge nurses, incorporating a pretest, PowerPoint training, scenario-based roleplays, and a posttest. …

Strategies To Mitigate Contractor Safety Noncompliance In The Construction Industry, Sallieann Wilson

Walden Dissertations and Doctoral Studies

Some contract managers lack clear communication channels with their contract stakeholders on construction safety noncompliance, which is a well-known industry challenge. Stakeholders, contractors, and workers of construction companies need to communicate more effectively with contract managers to ensure job-related injuries are minimized. Grounded in contingency theory, the purpose of this qualitative pragmatic inquiry research study was to explore the strategies contract managers use to mitigate contractor safety noncompliance with awarded contracts. Ten contract managers with more than 5 years of experience in contract or construction management participated in semistructured interviews guided by an interview protocol. Data were analyzed thematically, revealing …

Jenn-Ching Luo V. Owen J Roberts School District

2025 Decisions

USDC for the Eastern District of Pennsylvania

William Webb, Jr. V. Ruth Minner

2025 Decisions

USDC for the District of Delaware

Stephen Pender V. Commissioner Social Security

2025 Decisions

USDC for the District of New Jersey

Profit Point Tax Technologies Inc V. Dpad Group Llp

2025 Decisions

USDC for the Western District of Pennsylvania

Jenn-Ching Luo V. Owen J Roberts School District

2025 Decisions

USDC for the Eastern District of Pennsylvania

The Residual Impact Of Slavery On How Enslaved Black Females Defined And Made Meaning Of Sexual Violence: A Content Analysis, Suzanne R. Bates

Dissertations

Thompson-Miller & Picca (2016) and Feimster (2023) argued that enslaved African American women, and even free African Americans after the Civil War were victims of non-consensual sexual activity and rape. The NISVS report revealed that before the age of 18 years old, 35.5% of African American women experienced contact sexual violence, 29.5% experienced non-contact unwanted sexual encounters, and 20.7% experienced rape (Basile et al., 2022). Researchers of slave scholarship have made the case for the importance of including discourse on slavery and enslaved Black females’ experiences when discussing present day sexual violence among Black women in the US today (Balfour, …

The American Politics Of Firearms - The Case Between Illinois And Missouri, Michael J. Thompson

Dissertations

The issue of gun control is a hot topic in the field of American politics. It is a huge issue in the field of political science and in American public policy. In 2023, there were 18,874 firearm deaths in the United States, excluding suicides. The highest was in 2021 with the firearm related deaths at 21,068. One side argues that firearms can cause serious harm and death while the other side argues they can also reduce the rates of gun violence. There are different opinions on how to resolve the issue of mass shootings across the country. According to prior …

Exploring The Dynamics Of Online Engagement: A Social Exchange Theory Approach To The Baking Industry’S Use Of Social Media, Abagail Sweeney

Theses - ALL

This study investigates how organizations in the baking industry use social media to engage with consumers. Social Exchange Theory was applied to understand the dynamics in online interactions. A content analysis of the social media accounts for Insomnia Cookies, Lady M and Cake Bar was done for the months of January 2024 through March 2024. The platforms analyzed were Facebook, Instagram, X, TikTok and YouTube. Engagement was measured through likes, comments, shares and sentiment analysis. Post type was also observed to see what the users engaged with the most. The findings revealed that the number of active platforms did not …

Multiaxial Expansion Of 4d-Printed Shape Memory Polymer Scaffolds Via Programming Via Printing (Pvp), Verona Hendricks

Theses - ALL

Shape memory polymers (SMPs) offer unique opportunities for engineering responsive medical devices that can adapt to changing anatomical environments. However, most SMP-based systems are limited to uniaxial deformation which restricts their ability to conform to complex geometries found in soft tissue applications. Moreover, 3D approaches to print and program SMPs have demonstrated printed parts that can contract, but printed parts that can expand after printing has not been demonstrated to date. This work presents the design, fabrication, and evaluation of a 4D-printed SMP scaffold capable of controlled expansion along all three orthogonal axes (x, y, and z). Utilizing a method …

Roles Of Sex And Education Level With Alcohol Use Milestone Attainment And Progression, Elisabeth P. Cabot

Theses - ALL

Emerging adults report the highest rates of alcohol use, with drinking patterns varying by sex and education level. Few studies have explored how these factors relate to the attainment and progression of alcohol use milestones. The current study addresses this gap by examining the associations between sex, education level and alcohol use milestone progression and attainment in emerging adults. Secondary data analyses were conducted using National Epidemiological Survey on Alcohol and Related Conditions-III (NESARC-III) data (N = 36,309, Mage = 45.63 [SD = 17.53], female = 56%, 53% White, 21% Black, 19% Hispanic and 2% Multiracial). Ordinal regressions indicated males …

Supervised Dimensionality Reduction Techniques For Undersampled Applications, Joshua Kortje

Theses - ALL

Supervised dimensionality reduction (SDR) is a critical field in machine learning. The ability to compress data with high dimensionality can lead to better data visualization, pattern recognition, and classification performance. In order to develop SDR algorithms with the widest possible applicability, it is imperative to formulate approaches based on simple, generalizable models. The general Gaussian assumption provides a model that allows for closed-form expressions of information-theoretical criteria which can lead to analytical SDR solutions. Since Gaussian populations are completely defined by their first and second moments, solutions for this model can also lead to simple projection schemes with interpretable results …

Vanuatu And The International Court Of Justice: A Food Studies Approach To Climate Governance And Power, Amy Katherine Bentley

Theses - ALL

Vanuatu is a leader among small island developing states (SIDS) working to influence global climate change governance, using international diplomacy as its best defense against the climate crisis. In 2023, Vanuatu spearheaded a successful campaign for the United Nations General Assembly to request an advisory opinion (AO) from the International Court of Justice (ICJ) clarifying nations’ legal obligations related to climate change. This study uses a food studies approach to explore Vanuatu’s success in its climate governance campaign, focusing on the relationships between food sovereignty, climate justice, and power. To investigate this subject, I used an interdisciplinary literature review and …

Detection Of Bacterial Genomic Dna Fragments Using The Mxene Crispr-Cas9 Field-Effect Transistor, Jiaoli Li, Ali Taheri, Weijia Liu, Ying Zhuo, Pengfei Ma, Chenglin Wu

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Clustered regularly interspaced short palindromic repeats (CRISPR)-based field-effect transistor (FET) sensors provide a promising platform for highly specific and amplification-free nucleic acid detection. However, their direct application in identifying target sequences within intact genomic DNA remains underexplored. We developed a CRISPR-Cas9 FET sensor for detecting DNA sequences by immobilizing Cas9 onto a graphene-MXene sensing interface via (3-aminopropyl)triethoxysilane (APTES) functionalization. The sensor targeted Stx1, a 440 bp laboratory-amplified fragment associated with Shiga toxin production in pathogenic E. coli. Gel electrophoresis confirmed the precise cleavage of Stx1, while the nontarget sequence Stx2 remained undetected. FET measurements further validated the sensor's specificity, showing …

Editor’S Note, Thana Khawcharoenporn

Asian Medical Journal and Alternative Medicine

No abstract provided.

The End Of The Beginning Of Human Pluripotent Stem Cell Therapy, Pakpoom Kheolamai

Asian Medical Journal and Alternative Medicine

No abstract provided.

Clinicopathological Features Of Basal Cell Carcinoma Of The Skin At Thammasat University Hospital, Treepob Tassanawarawat, Worapop Suthiwartnarueput

Asian Medical Journal and Alternative Medicine

Background: Basal cell carcinoma (BCC) is one of the most common skin cancers that may result in local invasion and poor cosmetic appearance if left untreated or inadequately excised with tumor remaining in the surgical margin. BCC incidence rates are increasing but the number of studies from Thailand is limited.

Objective: To study the clinical and histopathological features of BCC in Thailand and classify lesions as Low- or high-risk and determine factors associated with infiltrated surgical margins.

Materials and Methods: This is a retrospective descriptive study that was conducted at Thammasat University Hospital, Thailand between January 2017 to September 2023. …

Bronchodilator Responsiveness And Clinical Outcomes In Patients With Chronic Obstructive Pulmonary Disease, Kritti Tirakitpanich, Narongkorn Saiphoklang

Asian Medical Journal and Alternative Medicine

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized as expiratory airflow limitation in individuals with significant smoking history. Bronchodilator responsiveness (BDR) might be shown in some COPD patients and might be associated with clinical outcomes.

Objectives: To determine the BDR prevalence and the correlation between BDR and clinical outcomes in COPD patients.

Methods: A cross-sectional study was conducted on stable COPD patients at Thammasat University Hospital between March 2019 and January 2022. Demographics, respiratory symptoms and functional capacity assessed by modified Medical Research Council, COPD Assessment Test, 6-minute walking distance, clinical outcomes (exacerbation, hospitalization, rescue medication use), and pulmonary functions …

Comparison Of Post-Thyroidectomy Scar Outcomes Using Polydioxanone Vs Polyglactin 910 Sutures In The Subdermal Layer, Thitima Meunsan, Navamon Plasen

Asian Medical Journal and Alternative Medicine

Introduction: Incidences of thyroid tumors are increasing followed by the rising of thyroidectomy and incidence of surgical scar. Precise subdermal approximation with an absorbable suture material that provides prolonged support to the wound has been found to reduce scar formation.

Objectives: To compare post-thyroidectomy scar outcomes between Polydioxanone (PDS) and Polyglactin 910 (Vicryl) in subdermal sutures.

Methods: A total of 32 participants undergoing thyroidectomy were divided into 2 groups with 16 patients in each group at Thammasat University Hospital from February 10th to November 30th, 2019. In Group1, Polydioxanone 4-0 was used for subdermal layer suture, whereas, in Group2, Polyglactin …