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Discontinuation Of Hydroxychloroquine Due To Suspected Retinal Toxicity In Systemic Lupus Erythematosus And The Role Of Multimodal Imaging, Burak İnce, Mehmet Bedi̇i̇ Oğurel, Zafer Cebeci̇, Yavuz Burak Tor, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Bahar Artim Esen

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effect of hydroxychloroquine (HCQ) on disease activity and damage in patients with systemic lupus erythematosus (SLE) in whom HCQ had previously been discontinued due to retinal toxicity, and to examine and reevaluate toxicity findings through a detailed ophthalmological examination.

Materials and methods: Patients with SLE who had been on HCQ for at least 3 years after achieving lupus low disease activity state (LLDAS) following remission induction, and were followed up for at least 3 years after HCQ discontinuation due to retinal toxicity diagnosed by visual field testing, were analysed. Disease activity, the number and severity of …

Evaluation Of Metabolic Uptake In Gynecological Organs Using Fdg-Pet In Women Diagnosed With Non-Gynecological Malignancies, Funda Atalay, Uğurcan Zorlu, Koray Aslan, Fatma Batak, Tuba Zengi̇n Aksel, Güli̇n Uçmak

Turkish Journal of Medical Sciences

Background/aim: Gynecological malignancies, including those affecting the uterus, cervix, vagina, vulva, and adnexa, pose significant physical and psychosocial burdens. Early detection and effective management of these malignancies are critical for improving outcomes. This study aims to evaluate metabolic uptake patterns in gynecological organs using fluorodeoxyglucose positron emission tomography (FDG-PET) and to analyze their malignancy potential in women with nongynecological cancers.

Materials and methods: A retrospective analysis was conducted on 221 women with nongynecological malignancies who exhibited pathological FDG uptake in gynecological organs on FDG-PET/CT imaging. Lesions were evaluated based on the standardized uptake value maximum (SUVmax), morphological characteristics on contrast-enhanced …

Diagnostic Accuracy And Potential Triage Utility Of The Shetty Test In Foot And Ankle Trauma: A Cross-Sectional Study, Burcu Doğan, Seval Komut, Erdal Komut, Nezi̇h Kavak, Osmancan Güneş, Anilcan Tahsi̇n Karahan

Turkish Journal of Medical Sciences

Background/aim: Foot and ankle trauma represents a common reason for emergency department visits. While the majority of cases involve soft tissue injuries, radiographic imaging is frequently overutilized due to concerns about missed fractures, leading to increased costs and emergency department crowding. The Shetty test, a recently introduced clinical decision rule, may serve as a simpler alternative to established tools such as the Ottawa ankle rules. This study aimed to assess the diagnostic accuracy of the Shetty test and its potential role as a supportive tool within existing triage systems for patients presenting with foot and ankle trauma.

Materials and methods: …

Ultrasonographic And Elastographic Evaluation Of Plantar Fascia And Achilles Tendon Alterations In Type 2 Diabetes Mellitus, Rifat Bozkuş, İhsani̇ye Süer Doğan, Berna Turhan, Sümeyya Duran Kaymak, Mustafa Hulusi̇ Kurt, Rasi̇me Peli̇n Kavak

Turkish Journal of Medical Sciences

Background/aim: The primary aim of this study is to compare the thickness and stiffness of the PF and AT between healthy volunteers and patients with type 2 diabetes mellitus (T2DM). A secondary objective is to explore the correlations between the thickness and stiffness of the PF and AT with diabetes duration (in months) and hemoglobin A1c (HbA1c) levels in T2DM patients without peripheral neuropathy or foot ulcers, with peripheral neuropathy or with foot ulcers.Material and Methods: A total of 289 participants, including 117 healthy volunteers (Group A) and 172 T2DM patients (59.5%), matched for age, sex, and body mass index, …

Detection And Quantification Of Microplastics In Cerumen, Bengi̇ Arslan, Yüce İslamoğlu, Ali̇ Sami̇ Berçi̇n, Selen Akbulut, Mehmet Meli̇koğlu

Turkish Journal of Medical Sciences

Background/aim: Microplastics (MPs) are a growing concern due to their pervasive environmental presence and potential environmental and human exposure impacts. Given evidence of systemic MP presence in human tissues and fluids, and the ear canal's environmental exposure, this novel study aimed to identify these particles in human cerumen. Cerumen was collected from the proximal ear canal to minimize potential airborne contamination.

Materials and methods: Cerumen samples were prospectively collected from 12 adult patients (23 patient-derived specimens) and 3 control water samples, following ethical approval and consent. Samples were extracted using sterile instruments, stored in glass, diluted, and filtered through 0.22 …

Addition Of Antimicrobials To Oral Sprays Containing Non-Steroidal Anti-Inflammatory Drugs Does Not Reduce The Severity Of Postoperative Sore Throat: A Prospective, Randomized, Placebo-Controlled Trial, Peli̇n Yildiz, Mobi̇n Hemmati̇, Leyla Kutlucan, Tankut Uzun, Togay Müderri̇s

Turkish Journal of Medical Sciences

Background/aim: Postoperative sore throat (POST) is a common complication following general anesthesia that significantly affects patient satisfaction, prolongs recovery, and increases treatment costs. This study aimed to evaluate whether the addition of antimicrobial agents to NSAID-based oral sprays could enhance the preventive efficacy against POST.

Materials and methods: In this prospective, randomized, placebo-controlled trial, 105 patients (ASA I–II; age 18–65 years) scheduled for elective ear surgery under general orotracheal anesthesia were enrolled. Patients were randomly allocated into three groups: a placebo group; a flurbiprofen oral spray group; and a group receiving an oral spray containing benzydamine hydrochloride, chlorhexidine digluconate, and …

Are Paraplegic Wheelchair Users Vulnerable To Overuse Syndromes?, Kutay Tezel, Esra Ülgen Kiratlioğlu, Hüseyi̇n Kayadi̇bi̇, İlkay Karabay, Mi̇tat Cebeci̇, Eda Gürçay

Turkish Journal of Medical Sciences

Background and Aims: The purposes of this study are to determine the frequency of upper extremity overuse syndromes in patients with spinal cord injury (SCI) using manual wheelchairs, to evaluate them clinically and sonographically, and to reveal possible factors that predispose to overuse syndromes.

Materials and methods: A total of 38 traumatic SCI patients who were over 18 years of age and manual wheelchair users were enrolled in this cross-sectional study. The patients were evaluated with clinical and sonographic findings of the wrist, elbow and shoulder joints. Functional capacity, physical ability and symptoms of upper extremity, and quality of …

Treadmill-Based Submaximal Vo₂ Estimation In Patients With Coronary Artery Disease: Can A Model Derived From Healthy Individuals Be Valid?, Levent Karataş, Esra Sena Orbak Yeni̇dünya, Nesri̇n Demi̇rsoy

Turkish Journal of Medical Sciences

Background/aim: Existing treadmill-based VO₂ prediction models may not accurately estimate submaximal VO₂ in patients with coronary artery disease (CAD), as they are often derived from healthy populations. This study aimed to develop and validate a submaximal VO₂ prediction model derived from healthy individuals and tested for generalizability in CAD patients by incorporating clinically relevant parameters.

Materials and methods: A retrospective analysis was conducted with 101 participants (54 healthy, 47 CAD patients) undergoing cardiopulmonary exercise testing using the modified Bruce protocol. To better represent the submaximal VO₂ reached during exercise, the average VO₂ in the last minute of each stage was …

Prognostic Role Of Systemic Immune-Inflammation Index And Pan-Immune-Inflammation Value In Acute Methanol Poisoning, Hati̇ce Şahi̇n, Gülay Ulusal Okyay, Fatma Ayerden Ebi̇nç, Fevzi̇ Coşkun Sökmen, Emre Yaşar, Gülşen Akçay, Mehmet Deni̇z Ayli

Turkish Journal of Medical Sciences

Background/aim: Acute methanol poisoning (MP) poses a significant public health challenge, with inflammation increasingly recognized as a key factor in its pathophysiology. Identifying accessible and reliable prognostic biomarkers could help enhance clinical outcomes. This study aimed to assess the prognostic value of the Systemic Immune-Inflammation Index (SII) and the Pan-Immune-Inflammation Value (PIV), measured upon emergency department admission, in predicting in-hospital mortality in patients with acute MP.Material and methods: This retrospective study included patients diagnosed with acute MP at two tertiary care centers in Ankara, Türkiye [University of Health Sciences Dışkapı Yıldırım Beyazıt Education and Research Hospital (January 1, 2015–October 1, …

Mirna-Target Gene Network Analysis In Siblings With Cystic Fibrosis And Phenotypic Variability, Ayberk Mustafaoğlu, Senem Noyan, Yeli̇z Z. Akkaya Ulum, Bala Gür Dedeoğlu, Nagehan Emi̇rali̇oğlu, Uğur Özçeli̇k, Ebru Yalçin, Deni̇z Doğru, Nural Ki̇per, Di̇dem Dayangaç Erden

Turkish Journal of Medical Sciences

Background/aim: Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF is characterized by respiratory tract infections, pancreatic insufficiency, meconium ileus, intestinal obstruction, and male infertility. A genotype to phenotype correlation is difficult to establish because of the heterogeneity of disease severity. Even patients with the same CFTR mutation can have varying clinical severities. In recent years, studies have explored the role of microRNA (miRNA) expression in the regulation of respiratory diseases. However, no research has been conducted to date on miRNAs in siblings with the same CFTR mutation. …

Metabolic And Genotypic Characterization Of Meropenem Susceptible And Resistant Serratia Marcescens Isolates, Şeyma Ni̇gi̇z, Gülşen Hazirolan, Gülşen Altinkanat Gelmez, Ceren Özkul Koçak, Engi̇n Koçak, Sevi̇lay Erdoğan Kablan, Emi̇rhan Nemutlu, Aycan Gündoğdu, Fatma Bayrakdar, Ufuk Hasdemi̇r, Deni̇z Gür

Turkish Journal of Medical Sciences

Background/aim: Serratia marcescens which is a nosocomial pathogen, is naturally resistant to a wide spectrum of antibiotics, which makes the management of infections difficult. The aim of this study was to determine the in vitro susceptibilities of S. marcescens to ceftriaxone, ceftazidime, meropenem, amikacin, gentamicin, ciprofloxacin, and to compare the metabolic profiles of meropenemresistant isolates under basal conditions and after exposure to sublethal concentrations of meropenem.

Materials and methods: A total of 84 S. marcescens isolates were included from various samples. Genes for meropenem resistance were determined by polymerase chain reaction (PCR). Genetic similarities among isolates of S. marcescens were …

Letter To The Editor Regarding “Kılıçarslan A, Kurt Çevik G, Doğan M, Aksoy Altınboğa A, Ceran F, Et Al. Does Cd47 Expression Have Prognostic Significance In Classical Hodgkin Lymphoma? Turkish Journal Of Medical Sciences: 2025; 55 (1): 22”, Burcu Baba, Ayşegül Akbay

Turkish Journal of Medical Sciences

No abstract provided.

Erratum To " The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model " [ Turkish Journal Of Medical Sciences 49 6 1789 1799], İnayet Güntürk, Cevat Yazici, Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Yay

Turkish Journal of Medical Sciences

Due to an inadvertent error during the labeling of images in the figure included in the article, the authors have provided a revised version of the figure. In this updated version, the image corresponding to the NAC-250 group has been replaced with a new photograph, and all labels have been corrected accordingly.

This correction does not affect the conceptual content, results, statistical analysis, or conclusions of the article.The authors apologize for any confusion this may have caused.

The original article can be accessed at: https://doi.org/10.3906/sag-1903-225

Erratum To " Vitamin D Deficiency And Surgical Cellulose Mimicking Parathyroid Adenomaafter Initial Parathyroidectomy " [ Turkish Journal Of Medical Sciences 55 3 696 701], Mustafa Şahi̇n, Volkan Genç, Koray Ceyhan, Demet Çorapçioğlu

Turkish Journal of Medical Sciences

We have identified that the article type of our publication entitled “Vitamin D deficiency and surgical cellulose mimicking parathyroid adenomaafter initial parathyroidectomy" was mistakenly entered incorrectly during the submission process. This error occurred due to an oversight at the time of submission.The correct article type should be Case Report instead of the previously indicated type. This correction does not affect the scientific content, results, or conclusions of the article.We apologize for any inconvenience this may have caused to our readers and the indexing services.

The original article can be accessed at: https://doi.org/10.55730/1300-0144.6017

The Impact Of The Doctor-Patient Relationship In Bipoc Women Suffering From Benign Gynecological Conditions, Gabriela Baez

Seton Hall University Dissertations and Theses (ETDs)

This study sought to gain a better understanding of the impact of the doctor-patient relationship on BIPOC women with benign gynecological conditions. The current study explored how wellbeing is impacted in BIPOC cis-gender women with benign gynecological conditions by measuring the quality of the relationship. General racism experience was also explored as a moderator on the impact of doctor-patient relationship on wellbeing. A total of 169 participant responses were included in this study. Hierarchical regression analysis demonstrated that there was a significant relationship between gynecological conditions and wellbeing. In addition, there was a significant negative relationship between racism experience and …

Does The Literature Empirically Support The Use Of Behavior Analysis In The Treatment Of Sports Related Concussions: A Systemic Review, Kayla Mckoy

Seton Hall University Dissertations and Theses (ETDs)

Although the literature supports the use of applied behavior analytic (ABA) interventions in the treatment of traumatic and acquired brain injuries, the question remains as to whether or not ABA procedures are an effective treatment option specifically for TBI associated with sports related concussion (SRC). The purpose of the present study was to review the literature available on the use of ABA with individuals diagnosed with sport related TBI to determine if there is enough research to empirically support the use of behavior analysis in the treatment of sport related concussions. The PRISMA method for systematic reviews was used to …

Exploring The Experiences Of Women Of Color High School Principals - An Investigation Into The Factors That Influence Their Longevity, Carmen Morales

Seton Hall University Dissertations and Theses (ETDs)

The underrepresentation of women of color in high school principal positions remains a persistent issue in educational leadership. This qualitative multi-case study explores the lived experiences of veteran women of color high school principals in northern New Jersey, investigating the factors that contribute to their longevity in the role. Through semi-structured interviews, document analysis, and observations, this study examines the intersectionality of race and gender in leadership, the barriers these women have encountered, and the strategies they have employed to sustain their leadership over time.

The findings highlight key themes, including the influence of mentorship and professional networks, the role …

Sexual Intervention Self-Efficacy In Clinical And Counseling Psychology Doctoral Trainees: Examining Education, Family Sexual Communication, And Sex Positivity, Sara Aigen

Seton Hall University Dissertations and Theses (ETDs)

Sexual wellbeing is a critical yet often overlooked aspect of psychological health. Despite its significance, many psychologists report discomfort and low self-efficacy in addressing clients’ sexual concerns. The current study examined factors associated with sexual intervention self-efficacy among doctoral trainees in clinical and counseling psychology. Specifically, it investigated whether family communication about sex and didactic education in sexuality predicted sexual intervention self-efficacy and whether sex positivity moderated these relationships. A cross-sectional survey design was employed with 166 doctoral students enrolled in APA-accredited programs across the United States. Participants completed a demographic questionnaire and measures assessing family sexual communication, sex positivity, …

A Systematic Review To Assess The Use Of Peer Mediated Interventions For Children With Autism When Autistic Children Serve As Peer Instructors And Models, Corinne Boyce-Swem

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in social communication, social interactions and restricted, repetitive and stereotyped patterns of behavior, interest or activities. These deficits hinder autistic children’s social and communicative skills. Peer-mediated interventions (PMIs) have been found effective in the development of communication, play and social skills in individuals with ASD. In PMIs typically developing children are trained to be peer models of socially acceptable behavior for children with ASD. This however may contrast with literature indicating that the most effective peer models are individuals who share similarities with the learner. The current study was …

Teacher Perceptions Of Instructional Coaching Impacts On Instructional Practice And Student Learning, Alpaslan Ozdogan

Seton Hall University Dissertations and Theses (ETDs)

This exploratory study investigates the role of instructional coaching in elementary education through the lens of teacher perceptions, with a focus on its influence on professional development, instructional methodology, educator well-being, and student academic achievement. The research pivots around four key questions examining the perceived impact of instructional coaches on:

1. Teachers' professional growth within elementary educational settings.
2. The evolution of instructional strategies and classroom practices.
3. The emotional and mental well-being of educators.
4. The academic performance and learning outcomes of students.

A narrative research approach was adopted, collecting and analyzing data through elementary teacher surveys, in-depth interviews with both teachers and …

The Association Of Adult Medicaid Beneficiaries’ Characteristics And Their Experience During The Covid-19 Pandemic, Frank R. Tortorella

Dissertations and Theses (Open Access)

Background: The COVID-19 pandemic disrupted the United States’ safety net program, Medicaid, for low-income individuals affecting access to care, increasing enrollment, and requiring new approaches to care delivery. The literature shows that beneficiaries’ personal characteristics influence their healthcare experience. This study investigated the association between Medicaid beneficiary characteristics and experience with their Medicaid health plan, examined if COVID-19 negatively impacted experience, and tested if COVID-19 moderated the relationship between beneficiary characteristics and experience.

Methods: The research sample was 76,976 adult Medicaid beneficiaries who voluntarily completed the annual Consumer Assessment of Healthcare Providers and Systems (CAHPS) health plan surveys in 2018 …

Futurist, Fang Wang, Katey Price, David L. Groves

Visions in Leisure and Business

No abstract provided.

The Fermat Quartic X4 + Y4 = 2m In Quadratic Number Fields, Jayanth Athipatla

Mathematics Faculty Publications

In this paper, we generalise to the family of Fermat quartics X4+Y4=2m,m∈Z, a result of Aigner [‘Über die Möglichkeit von x4+y4=z4 in quadratischen Körpern’, Jahresber. Deutsch. Math.-Ver. 43 (1934), 226–228], which proves that there is only one quadratic field, namely Q(−7−−−√), that contains solutions to the Fermat quartic X4+Y4=1. The m≡0(mod4) case is due to Aigner. The m≡2(mod4) case follows from a result of Emory [‘The Diophantine equation X4+Y4=D2Z4 in quadratic fields’, Integers 12 (2012), Article no. A65, 8 pages]. This paper focuses on the two cases m≡1,3(mod4), classifying for m≡1(mod4) the infinitely many quadratic number fields that contain solutions, …

Exploring Different Metal-Oxide Cathode Materials For Structural Lithium-Ion Batteries Using Dip-Coating, David Petrushenko, Thomas Burns, Paul Ziehl, Ralph E. White, Paul T. Coman

Faculty Publications

In this study, a selection of active materials were coated onto commercially available intermediate modulus carbon fibers to form and analyze the performance of novel composite cathodes for structural power composites. Various slurries containing polyvinylidene fluoride (PVDF), active material powders, 1-methyl-2-pyrrolidone (NMP) and carbon black (CB) were used to coat carbon fiber tows by immersion. Four active materials—lithium cobalt oxide (LCO), lithium iron phosphate (LFP), lithium nickel manganese cobalt oxide (NMC), and lithium nickel cobalt aluminum oxide (NCA)—were individually tested to assess their electrochemical reversibility. The cells were prepared with a polymer separator and liquid electrolytes and assembled in 2025-coin …

Transcriptomic And Epigenomic Profiling Of Immune Cells Responses To Simian Immunodeficiency Virus Infection In The Brain, Xiaoke Xu

Theses & Dissertations

Human immunodeficiency virus type 1 (HIV-1) is an enveloped retrovirus that significantly impairs the human immune system. A common complication of HIV-1 infection is HIV-associated neurocognitive disorder (HAND), which, prior to the introduction of antiretroviral therapy (ART), led to considerable morbidity and mortality due to untreated neuropsychiatric manifestations. Although ART has substantially reduced the incidence of HIV-associated dementia (HAD), approximately 50% of people living with HIV (PLWH) continue to experience milder forms of HAND. The CNS is seeded by HIV during the acute phase of infection. Once in the brain, HIV targets and activates resident immune cells, primarily microglia and …

A Replication And Extension Of The Enhanced Choice Model For Children Who Exhibit Challenging Behavior, Jessica Tran

Theses & Dissertations

Rajaraman et al. (2022) first introduced the Enhanced Choice Model (ECM) as an intervention that incorporates assent within the treatment framework. Shortly after, Staubitz et al. (2022) and Rajaraman et al. (2024) added to the literature available specifically regarding the ECM. Despite the initial successes of the ECM, it has only been applied to nine individuals. Of these, only two needed some form of modification to the treatment model. The criteria for these modifications was not specified within previous literature. Therefore, the purpose of the current study was twofold. First, we extended previous research by evaluating systematic modifications to the …

Revisiting Android Permission Evolution Through Temporal Analysis: A Data-Driven Study Of Behaviors And Implications, Ali Al Kinoon

Graduate Thesis and Dissertation post-2024

Malicious applications continue to pose significant privacy and security risks within the Android ecosystem, often exploiting user permissions and obscuring data collection practices behind opaque privacy policies. To address these challenges, this dissertation presents a comprehensive framework for enhancing Android app security through dataset construction, permission behavior analysis, and privacy policy classification. The framework systematically investigates key issues such as dataset fidelity, permission misuse, model performance, and the alignment between declared and actual data practices. Through a combination of empirical analysis and machine learning techniques, this work advances the development of more transparent and secure mobile applications. The first part …

Analyzing The Global Changes In The Seasonal Cycle Of Sea Level, Storm Surge, And Ocean Waves, Amanda Barroso

Graduate Thesis and Dissertation post-2024

Changes in the seasonal cycle of extreme sea level components can modulate the flooding risk along coastlines. This dissertation evaluates the changes in and potential co-occurrence of the seasonal cycles of mean sea level, storm surge, and ocean waves. Seasonal cycles characterize the generally expected climate conditions throughout the year with distinct high and low patterns. These regular and predictable cycles have shown non-stationarity in some locations across the globe. This means the timing of the expected peak may shift to occur earlier or later. Shifts in the timing of the maximum sea level impact coastlines with increased risk of …

Numerical Evaluation Of A Novel Transpiration Cooling Scheme For Use In Dynamic Control Of Atmospheric Entry System, Caroline J. Anderson

Graduate Thesis and Dissertation post-2024

Future space exploration missions require sustainable, efficient thermal protection systems for atmospheric entry, instead of disposable ablative shields. Transpiration cooling has interest as a long studied method but never used for missions to date, prompting further study to address concerns of flow transition downstream. In consideration of additional need for aerodynamic maneuvering for greater landing accuracy, a novel asymmetric scheme of transpiration cooling is presented as a method of using onboard coolant to meet entry trajectory maneuvering requirements. This numerical study creates a coupled model of vehicle-scale flow domain and material-scale thermal response to converge on accurate vehicle surface values.

Design And Development Of A Laser Diagnostic System For Ammonia And Nox Measurements In A Toroidal Jet Stirred Reactor At Atmospheric Pressure, Marzuqa Ahmed

Graduate Thesis and Dissertation post-2024

The need for more sustainable fuel alternatives in the modern aircraft industry is growing. SAF is the current sustainable fuel in use, but still produces harmful carbon emissions. A promising alternative to SAF is ammonia, which produces zero carbon emissions. By decomposing ammonia (NH₃) into its constituents of N₂ and H₂ using a chemical catalyst, a hydrogen-ammonia fuel mix is created. H₂/NH₃ mixtures still have the desired characteristic of burning without carbon emissions, but are less reactive than pure hydrogen. Additionally, ammonia is a widely used compound, so infrastructure already exists for production, …