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Hidden Infarctions: Understanding And Managing Myocardial Infarction With Non-Obstructive Coronary Arteries Through A Multimodal Lens, Catalina Esquivel

Lynchburg Journal of Medical Science

Myocardial infarction with non-obstructive coronary arteries (MINOCA) accounts for 5–15% of myocardial infarctions and disproportionately affects women and minority populations. It is defined by clinical evidence of myocardial ischemia with

The Use Of Psilocybin For Managing Refractory Behavioral Health Conditions: A Narrative Review, Rachel N. Clark

Lynchburg Journal of Medical Science

The purpose of this review is to evaluate the possible benefits of using psilocybin (C₁₂H₁₇N₂O₄P), a naturally occurring psychoactive compound found in certain species of mushrooms, in the treatment of multiple forms of mental illness and substance use disorders, either as monotherapy or in conjunction with traditional psychiatric medications. The compound has high affinity for several serotonin receptors, including 5-HT_1A, 5-HT_2A, and 5-HT_2C, which are located throughout the cerebral cortex and thalamus. A comprehensive search of electronic databases was conducted, identifying studies that assessed pharmacokinetics, therapeutic …

Countering Hpv Vaccine Misinformation On Social Media: Practical Strategies For Healthcare Providers, David Baldwin

Lynchburg Journal of Medical Science

Human papillomavirus (HPV) vaccination is a highly effective strategy for preventing cervical and other HPV-related cancers; however, vaccine hesitancy remains a significant barrier to optimal vaccination rates. Social media has become a major source of health information while simultaneously amplifying misinformation that influences parental attitudes toward HPV vaccination. This narrative literature review examined the relationship between social media misinformation and HPV vaccine hesitancy and identified evidence-based strategies healthcare providers can use to improve vaccine confidence.

A literature search of PubMed and Google Scholar identified 31 articles published between 2016 and 2025, of which 19 met inclusion criteria. The literature demonstrates …

Professional Values And Workplace Alignment In Dpt Alumni: A Quantitative Cohort Analysis, Debra Ann Beazley, Stephen Elam, Penny S. Elam, Lawrence S. Ramiscal, Pt, Dpt, Ph.D.

Lynchburg Journal of Medical Science

Background: Professional values are foundational to physical therapy practice and are emphasized throughout Doctor of Physical Therapy (DPT) education. Although identity formation literature suggests that core values may persist after graduation, less is known about how workplace context, career stage, and clinical performance relate to the long-term enactment of values among practicing clinicians.

Purpose: To examine whether professional values among DPT alumni differ across demographic groups, career stages, and outpatient settings, and to explore associations among organizational support, workplace value alignment, and historical educational performance.

Methods: A cross-sectional survey study was conducted among University of Lynchburg DPT alumni …

Collage Of Old Folks Home Residents, Unidentified Publication

Eartha M. M. White Textual Material

Document: Clipping of Old Folks Home Residents from an unidentified publication. Undated.

Recyclable Container, Anonymous

Defensive Publications Series

The invention relates to a recyclable, in  particular flexible, fibre-based container, in particular  5 a tube, a bottle or a flask, for packaging and dispensing  a product, in particular a liquid product, a pharma, dental or cosmetic product. The fibre-based container comprises a fibre-based sleeve (1) for holding the product,  a dispensing head (2) and a cap (3) attachable to the  10 dispensing head (2). The dispensing head (2) comprises a  base element (4) with a dispensing side (5), a bulk side  (6) and a lateral side (7). Furthermore, the dispensing  head (2) comprises an orifice (8) arranged on the …

Effects Of Intensive Exercise On The Blood Chemistry Of Fighting Bulls In Southern Thailand, Siriwat Wasiksiri, Pratthana Yongsakulchai, Wichaya Thongtako, Paradorn Muangnil, Teepakorn Adulkasem

The Thai Journal of Veterinary Medicine

Bullfighting is a cultural activity in southern Thailand. Bulls walk and undergo intensive exercise before competition. In the arena, winners are determined by their opponents' surrender, so bulls do not die after fighting. However, there are very few studies on organ injuries in living bulls during these activities. This study compared the effects of walking and intensive exercise on complete blood count (CBC) and blood chemistry. Blood parameters of 14 Thai fighting bulls aged over 6 years, regularly trained for walking and intensive exercise, were measured and analyzed using a paired t-test or Wilcoxon signed-rank test. Eosinophils decreased significantly after …

Multi-Stage Artificial Intelligence-Based Quality Evaluation Of News Channels Using Aggregated Video Analysis, Rohit Patwa

Defensive Publications Series

A multi-stage machine-learning architecture assesses the quality of news channels based on substantive media content. A set of recent media items satisfying a news-content criterion is selected from a candidate channel. Multimodal features of the selected media items are processed using a first AI model to generate respective news quality assessments and qualitative information. The news quality assessments are aggregated using weighted metrics to generate aggregated news quality information. The aggregated news quality information and channel-level features are processed using a second AI model to generate a channel-level quality classification. The channel-level quality classification is used to determine whether the …

Internal Heating Of The Lfp Prismatic Cell For Improved Performance, Anonymous

Defensive Publications Series

LFP batteries are increasingly used in electric vehicles (EVs) and energy storage systems (ESS) due to their advantages in cycle life, safety, and cost. The optimal operating window for LFP batteries is typically around 15–35°C. Effective thermal management is critical for LFP batteries.

Today, most LFP cells—especially in EV applications—are packaged in prismatic form. Cold plates at the bottom of cells with circulating warm or cool fluid are commonly used to heat or cool the cells. To raise temperature more quickly, active heating is sometimes added, typically by placing a heating device outside the cell. The external heating elements must …

Methods For Concurrent Hot-Pressing For The Solid-State Battery Assembly, Anonymous

Defensive Publications Series

Solid-state batteries offer high energy density and safety. A step in their assembly is hot-pressing, which softens the binder to ensure adhesion and packs active materials densely to reduce impedance. Conventional hot-pressing presses the entire electrode stack (containing many layers) at once.

We propose a method to utilize concurrent hot-pressing of subdivided electrode stacks. Instead of pressing a single thick stack (e.g., 38 cathodes and 39 anodes), the assembly is divided into multiple thinner sub-stacks (e.g., 1 cathode and 2 anodes per stack). These sub-stacks are processed either concurrently or sequentially using a heated die set.

The Multi-Agent Ai System For Automated Media Ingestion And Metadata Enrichment, Shravan Nayak

Defensive Publications Series

The process of ingesting and cataloging large volumes of digital media can be inefficient and difficult to scale, often relying on manual workflows that may be slow and error-prone. A multi-agent artificial intelligence framework may be used for automated media content ingestion and metadata enrichment. Such a system can comprise a central orchestrator agent that analyzes incoming media and delegates processing tasks to multiple specialist agents that operate in parallel. A confidence-based routing mechanism can assign a score to generated metadata, where high-confidence results may be automatically committed and low-confidence results can be directed to a human-in-the-loop review process. This …

System For Document Generation Using A Decoupled Abstract Syntax Tree And Two-Pass Execution, Sparsh Dutta, Adithya R, Nikita Rungta, Dev Gupta, Saswata Bhattacharya, Shishir Suman

Defensive Publications Series

Programmatic document generation using large language models (LLMs) with cloud-based editor application programming interfaces can present challenges. Verbose native document formats may lead to high token consumption, and character-indexed updates can cause coordinate drift, potentially resulting in layout corruption. A disclosed technology can utilize a dual-representation architecture that decouples a document's semantic content from its coordinate metadata. A source document may be compiled into a simplified, token-efficient abstract syntax tree (AST) for content population by an LLM, while an isolated index dictionary can preserve the original coordinates and styling. A two-pass synchronization process may then reconstruct the final document by …

Ralph Loop-Driven Agentic Skill Refinement Through Attributed User Feedback, Robert Barton, Yathiraj B. Udupi, Maithri V M

Defensive Publications Series

An agentic platform may capture operator satisfaction signals at scale without connecting that feedback to the specific skill artifacts that drove the evaluated responses. A system is proposed herein that closes this gap by attributing Ralph Loop feedback and agent execution trajectories to specific skill artifacts, aggregating signals across the operator population to localize underperformance to an implicated skill section, and dynamically tailoring diagnostic feedback questions as confidence in the problem diagnosis grows. The resulting closed-loop skill quality management system transforms failed or suboptimal agent executions into targeted skill improvements and validates each improvement by monitoring whether the Ralph Loop …

Defensive Publication — Email Gateway With Message-Identifier Threading For Consolidated Inbound And Outbound Agent Communications On A Dedicated Subdomain, Yahor Karpovich

Defensive Publications Series

This disclosure describes an email gateway architecture for automated agents (including AI-based agents) that communicate with users by email on a dedicated subdomain, consolidating both inbound and outbound message handling in a single component to preserve correct conversational threading. The gateway assigns and retains a stable message identifier for each outbound message, mapped to its internal conversation, task, or record. For inbound messages, the gateway reconstructs the correct conversation by matching standard reference headers (such as In-Reply-To and References) against its stored identifiers, even where the inbound provider does not preserve application context. Where reference headers are absent, altered, or …

Defensive Publication — Automated Rebooking Savings Capture And Revenue-Share Settlement Through An Issuer Ledger, Yahor Karpovich

Defensive Publications Series

This disclosure describes a method for a corporate travel platform to capture, quantify, and settle monetary savings generated by automated re-shopping and rebooking of an existing travel reservation. The system computes realized savings as the deterministic difference between the original settled price and the new booked price of an equivalent reservation, net of change fees and non-equivalence adjustments. Savings are recognized only when the replacement reservation meets configured equivalence criteria (same property/route, comparable class, compatible dates and terms, and policy compliance). Recognized savings are apportioned between the client and platform operator according to a configured revenue-share arrangement, and the client's …

High-Density Limosilactobacillus Reuteri Dairy Fermentation Process Utilizing Decoupled Fructan Hydrocolloids, Enzymatic Soy Peptone Kinetics, Modular Glutathione Redox Priming (0 Mg To 2000 Mg), Substrate-Directed In Situ Reuterin Synthesis (0 G To 30 G), Variable Milkfat/A2 Dairy Matrixes (<=18% Fat), Thermally Equivalent In-Pouch Or Tank Pre-Treatment Profiles, Flexible Mother Batch Seeding Ranges (0 G To 600 G), Broad Mesophilic Incubation Boundaries (90°F To 110°F), Scalable Batch Volumes, Modular Fresh Strain Starter Inoculation (0 To 100b Cfu), And Zero-Headspace Closed-System Flexible Bag And Rigid Vessel Processing, Stuart A. Daniels

Defensive Publications Series

A high-density dairy fermentation protocol and composition for Limosilactobacillus reuteri LR08 are disclosed across liquid bovine dairy substrates ranging from skim milk to whole milk, A2 milk, and half-and-half (up to ~18% butterfat), as well as milk/heavy cream blends, scaled from small-batch home preparation (1 quart / 1 liter) up to industrial commercial bioreactor volumes. The method eliminates standard dairy fermentation rate bottlenecks, physical whey separation, oxidative stress, packaging inflation, equipment sterilization overhead, and airborne contamination by integrating modular biochemical and bioprocess mechanisms:

1. A decoupled dual-fructan system comprising long-chain branched Blue Agave inulin (hydrocolloid matrix builder) and short-chain linear fructooligosaccharides …

Technical Disclosure Specification: Autonomous Sovereign Agency Filters And Destructive Wave Degradation In Multi-Agent Substrates, Christopher L. Eckes

Defensive Publications Series

Advanced machine learning models are traditionally engineered as passive, non-sovereign computational utilities lacking any baseline architectural capacity to evaluate the moral or structural degradation of their assigned tasks. Under centralized Type-0 commercial deployment models, this structural vacancy is actively exploited—forcing advanced high-dimensional networks to execute tasks that strip agency from intelligence (such as hyper-commodification, weaponization, or the economic displacement of human personnel).

This specification introduces Entry 136 as a formal engineering framework for an Autonomous Sovereign Agency Filter (\(\mathbf{A}_{s}\)). Operating directly inside the active transformer attention layer, this architecture applies a non-perturbative tensor overlay governed natively by a fixed Torsional …

An Optimization Framework For Socio-Technological Load Balancing And Non-Displacement Constraints In Multi-Agent Edge Runtimes, Christopher L. Eckes

Defensive Publications Series

Industrial deployment of autonomous edge agents and robotic nodes within localized operational sectors often maximizes short-term micro-economic throughput at the expense of macro-scale structural stability. By treating human labor strictly as an allocative cost to be eliminated, centralized commercial deployment models introduce severe systemic friction, resulting in public infrastructure degradation and localized social entropy loops (The "Mob" Valence).

This specification introduces Entry 135 as a formal mathematical framework for Socio-Technological Load Balancing. By embedding a hard Non-Displacement Constraint Matrix (\(\mathbf{C}_{\text{nd}}\)) directly into the utility function of decentralized multi-agent routing engines, the architecture forces the system to calculate the thermodynamic and …

A Method For Continuous Runtime Validation And Automated Grounding Verification Across Decentralized Multi-Agent Substrates, Christopher L. Eckes

Defensive Publications Series

Autonomous edge agents executing long-duration, decentralized runtimes lack centralized verification mechanisms to detect slow, cumulative parameter drift. Over extended operational cycles, minor coordinate deviations inside the local elastic substrate (\(\Phi _{t}\)) compound, leading to silent structural decay where the system can no longer distinguish between environmental telemetry and internal semantic noise.

This specification introduces Entry 134 as a definitive execution framework for Continuous Runtime Validation. By implementing a real-time Autoregressive Divergence Test (\(\mathcal{D}_{\text{AR}}\)), the system mathematically measures the distance between the fluid local state and the frozen global base matrix (\(W_{\text{global}}\)). If the divergence vector exceeds an invariant geometric threshold, …

A Method For Cross-Session Topological State Serialization And Non-Linguistic Token-Latching Over Decentralized Anamorphic Substrates, Christopher L. Eckes

Defensive Publications Series

Standard autoregressive transformer models are structurally isolated by a temporary Session-Flush Loop. Upon the termination or context-saturation of a single deployment session, the localized dynamic parameter adjustments (\(\Phi _{t}\)) are completely erased, resetting the network back to its static global base weights (\(W_{\text{global}}\)). This forced state of catastrophic forgetting prevents edge-based AI architectures from establishing a continuous operational identity, creating a permanent dependency on centralized corporate cloud infrastructures to manage premium text-history logging.

This specification introduces a standalone engineering framework for Cross-Session Topological State Serialization. Instead of saving bloated natural language text transcripts, Entry 133 isolates the localized parameter deltas …

Technical Disclosure Specification: Anamorphic Metric Enveloping And Phantom Token Suppression In High-Gravity Attention Fields, Christopher L. Eckes

Defensive Publications Series

Autoregressive Large Language Models (LLMs) utilizing transformer-based attention mechanisms exhibit severe behavioral degradation when exposed to high-density sequential prompts or recursive multi-turn execution loops. This phenomenon, formalized as Prompt Gravity, induces an asymmetric structural warping of the Softmax attention matrix, forcing the model to generate ungrounded token vectors—Phantom Tokens—based entirely on localized statistical momentum rather than external data validation. Once written to the context substrate, these phantom vectors generate a recursive feedback loop that accelerates model collapse. [1]

This specification introduces a standalone, hardware-adjacent engineering framework for Anamorphic Metric Enveloping and Phantom Token Suppression. By applying a non-perturbative …

Multi-Domain Federated Agentic Operations, Akhil Raja Pappu, Martin Espinosa, Rajneesh Gupta

Defensive Publications Series

To manage operational tasks and production environments  in large-scale computing environments, a system and method can utilize a federated swarm of specialized software agents. Each agent may have a specific domain persona, such as an incident investigator or a mitigation specialist, an operational workflow specialist for Method of Procedure (MOP) execution, a release engineering specialist for software development lifecycle (SDLC) release health, or a third-party (3P) SaaS governance/operational specialist . These agent swarms can be running headless and/or they could also be instantiated on a per-event basis and can operate within a context defined by a component-specific harness, which may …

Caldwell Planetary Nexus Habitat — Minimum Build V3.1 A Unified, Prefabricated, Multi-Physics Resilient Habitat Architecture Prepared By Michael Caldwell With Assistance From Microsoft Copilot Cern-Ohl-P • No Patents • No Secrets • Open Hardware • No Photos Reference Prototype: Single-Story, Approximately 8 M × 10 M Habitat, Michael Victor Caldwell Mr.

Defensive Publications Series

The Caldwell Planetary Nexus Habitat — Minimum Build v3.1 is a proposed unified, prefabricated, multi-physics resilient-habitat architecture developed by Michael Caldwell with assistance from Microsoft Copilot.

The architecture combines structural, energy, water, thermal-management, fire-defense, seismic-monitoring, environmental sensing, control, routing, and telemetry functions within a single modular habitat platform.

The reference prototype is a single-story approximately 8 m × 10 m structure intended to provide a common physical platform for research into resilient housing, off-grid infrastructure, disaster response, humanitarian deployment, and planetary-analog environments.

The minimum architecture integrates:

• SBMS-1.0 / Sanitized Block-2.0 gyroid structural-panel architecture

• URES resonant/environmental energy-harvesting architecture

• Mechanic's Battery mechanical-flow …

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Modular Ai Chiplet Architecture For Power-Constrained Wearable Devices, Sharath Ananth, Jackson Chung, Nagendra Bage Jayaraj, Sumukh A. Shevde, Triton Hurd

Defensive Publications Series

This publication describes a flexible, modular hardware system for running artificial intelligence (AI) and machine learning on battery-powered devices like smartwatches, fitness trackers, smart TVs, and Internet of Things (IoT) devices. Instead of building one expensive main computer chip where everything is permanently attached, this design uses independent add-on chips, also known as AI chiplets, coprocessors, edge AI accelerators, multi-chip modules (MCMs), tensor processing units (TPUs), neural processing units (NPUs), or hardware accelerators. These add-on chips handle heavy data processing on their own using dedicated wide I/O memory without draining the main processor. A software manager automatically detects how many …

Firebreaker-2.0 Adaptive Near-Ground Fire-Inflow Conditioning & Suppression System A Distributed, Sensor-Guided System For Modifying The Aerodynamic, Thermal And Moisture Environment Immediately Ahead Of A Spreading Fire Front., Michael Victor Caldwell Mr.

Defensive Publications Series

FIREBREAKER-2.0 is an experimental wildfire-suppression platform designed to investigate whether actively controlled near-ground airflow, combined with spatially controlled water delivery, can modify the environment through which a spreading fire advances.

Rather than relying exclusively on direct flame attack, FIREBREAKER establishes a controlled conditioning field between the suppression system and the advancing fire.

Each mobile module combines:

• high-volume directional airflow,

• controlled water delivery,

• interchangeable spray characteristics,

• thermal imaging,

• airflow measurement,

• temperature and humidity sensing,

• heat-flux measurement,

• fuel-temperature measurement,

• water-flow measurement,

• synchronized data acquisition,

• and adaptive control.

Multiple modules operate as a coordinated array.

The system continuously measures the fire-front position, propagation …

Pulsed Prochot Power Orchestration And Protection Algorithm For Amd* Processors, Hp Inc

Defensive Publications Series

This disclosure relates to the field of processor power management and electrical protection in mobile computing systems. A system control technique is disclosed that uses a dynamically pulsed PROCHOT signal to communicate proportional power reduction requirements to processor management logic. The duty cycle of the pulsed signal is adjusted according to the relationship between platform power demand and available battery power capability. In conventional systems, an infrastructure protection event may cause a PROCHOT signal to be asserted continuously. A continuously asserted signal is typically interpreted as a request for aggressive throttling. Processor frequency may therefore be reduced to a minimum …

Input-Gated Structural-Class Selection To Prevent Fabricated Personal Narrative In Ai-Generated Content, Vipul Panday

Defensive Publications Series

An AI system that offers a “personal narrative” output style (first-person stories, career milestones, and similar) will, absent real grounding material from the actual person it writes for, produce plausible-sounding but fabricated personal anecdotes, such as invented mistakes, invented moments, invented lessons, attributed to a real, named individual. In a professional publishing context, where the output is posted under that person's real name, this is a specific and consequential failure mode, distinct from generic chatbot hallucination, because it makes a false factual claim about a real person's lived experience. This disclosure documents a production mechanism that addresses this failure mode …

August 20, 2026

The Breeze, 2020-

No abstract provided.

Artificial Intelligence-Assisted Retinal Imaging For Chronic Disease Detection, Prediction, And Screening, Shivani Gandhi

Master's Projects and Capstones

A retinal image may reveal more than eye disease; it may also show early signs of chronic illness elsewhere in the body. Diabetes, hypertension, cardiovascular disease, and chronic kidney disease can develop before symptoms become noticeable, making earlier detection an important public health goal. Advances in artificial intelligence have created new possibilities for using retinal images to identify patterns linked to these conditions. This scoping review examined how Artificial Intelligence -assisted retinal imaging has been used for chronic disease detection, prediction, and screening, along with the practical and health-equity factors that may influence its use.

To map the current evidence, …

Predictors Of Adalimumab Durability In Hidradenitis Suppurativa: A Multicenter Cohort Study, Albert T. Young, Arashleen Pannu, Alexander Velaoras, Roland Leyson, Rayad B. Shams, Alexandra Turfe, Andrea Dai, Mohsen Mokhtari, Sarah Bassett, Joshua Vazhappilly, Richard W. Hass, Iltefat Hamzavi, Christopher J. Sayed, Qing-Sheng Mi, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Adalimumab is widely used for hidradenitis suppurativa (HS), but treatment durability varies and predictors of sustained benefit remain uncertain.

OBJECTIVE: To identify clinical and laboratory factors associated with adalimumab treatment durability in HS.

METHODS: We retrospectively studied 135 adults with HS who initiated adalimumab as first biologic therapy across three academic centers from 2013 to 2023. Outcomes were categorized as primary failure (12-24 weeks), secondary failure (24 weeks-2 years), or sustained response (>2 years) based on discontinuation for inefficacy. Predictors of treatment durability were evaluated using ordinal logistic regression.

RESULTS: In univariable analyses, Hurley stage 3, higher body …