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The Cohort Space As Experienced By Latina Doctoral Students, Tiana Bierwert

Graduate Doctoral Dissertations

This phenomenological study explores how Latina Doctoral Students experience cohort spaces within graduate programs, focusing on the gendered and racialized challenges embedded in these environments. Utilizing pláticas as a culturally grounded method and guided by a Latina Feminist Phenomenological framework, this research examines how cohort models—which are often designed to foster support and collaboration—can instead exacerbate marginalization for students at the intersections of race and gender. Drawing on the conceptual frameworks of White Space and Counterspace, the study interrogates how cohort environments can operate as sites of exclusion and surveillance, where dominant norms are reproduced and where Latina Doctoral Students …

Factors Associated With Discrimination-Related Distress Among Sexual And Gender Minority Individuals: A Predictive Analysis, Emylia Terry

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sexual and gender minority (SGM) individuals face disparate rates of mental health outcomes, such as psychological distress, which contributes to suicidality. This may be attributable to minority stress, which posits that health inequities impacting this community are driven by increased exposure to stigma- and discrimination-related stressors. The negative physical and psychological health impacts of psychological distress and discrimination are well-documented in the literature. Structural stigma – in the form of harmful anti-LGBTQIA+ laws and policies – is associated with increased suicidality. However, little is known about factors associated with perceived discrimination occurrences and discrimination-related distress. First, a systematic review was …

Hot Spring Associated Infectious Diseases In The Great Basin And Southwest, Matthew Bentz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Like all bodies of freshwater, natural hot springs can harbor pathogenic microorganisms that carry the threat of infectious disease. The unique chemistry, increased temperature, and popularity for bathing may alter the risk profile of hot springs compared to other natural bodies of water. Despite this risk, the role of hot springs as a reservoir for infectious diseases remains understudied, particularly within the context of regional public health. Nevada and the Great Basin/Southwest have increasingly promoted hot springs for the purposes of tourism, and they share a strong link to the cultural heritage of the region. The unknown risk profile and …

The Speech-To-Song Illusion Across Development And The Effects Of High-Level Expectations, Rodica R. Constantine

UNLV Theses, Dissertations, Professional Papers, and Capstones

The typical listener can readily categorize auditory stimuli as either speech or song even though these structures share many acoustic similarities. These musical and linguistic categories may nevertheless take time to develop as children acquire language- and music-specific knowledge. In the Speech-to-Song (STS) illusion, multiple repetitions of a natural spoken utterance can give rise to a perceptual switch wherein the stimulus begins to sound song-like to the listener. While the STS illusion has been well-researched in adult listeners, it had yet to be investigated in children. In our study, we examined whether children experience the STS illusion by presenting participants …

Understanding Ore Deposit Scale Controls On Au Enrichment In Carlin-Type Au Mineralization: A High-Resolution Study Of The Rita K Deposit, Conner T. Callaway

UNLV Theses, Dissertations, Professional Papers, and Capstones

Controls on the distribution of gold (Au) within the Rita K Carlin-type deposit are poorly understood. The primary Au-bearing carbonate unit Wispy, is a bioturbated muddy limestone with debris flow clasts that range in size but are typically >5 cm occurring in the lower sections. The orebody is described as a syncline-anticline pair that hosts high-grade Au ore in the fold hinges. The spatial relationship between Au mineralization and fold hinges suggests that shortening due to folding is an important mechanism producing Au-enriched zones. However, the exact mechanism of Au enrichment and deposit-scale controls on Au distribution and fluid evolution …

Empowering Science With The World's First High Accuracy And High Throughput Functional Assay, Christopher Giacoletto

UNLV Theses, Dissertations, Professional Papers, and Capstones

Understanding the functional consequences of genetic mutations remains a central challenge in modern biology, with far-reaching implications for human health and disease. While early systematic methods like alanine scanning and phage display provided foundational insights into protein structure and function, the emergence of high-throughput approaches—such as Multiplexed Assays of Variant Effect (MAVEs)—and predictive tools powered by artificial intelligence have vastly expanded our ability to profile mutational landscapes. However, these methods are often constrained by trade-offs between accuracy, scalability, and biological relevance.This dissertation presents the development and application of the GigaAssay, the world’s first high-throughput functional assay capable of delivering both …

Integrated Uav Platform For Multi-Spectral, Thermal, And Eos Imaging In Wildfire Monitoring And Modeling, Md Shariful Islam

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis presents the design and development of a modular unmanned aerial vehicle (UAV) system based on a quadcopter platform for flexible and efficient wildfire-related multimodal image acquisition. Addressing key limitations in ecological UAV monitoring such as sensor inflexibility, time-consuming reconfiguration, and imprecise image georeferencing, the system introduces a versatile payload integration framework supporting three distinct imaging sensors: MicaSense Altum-PT, FLIR Vue Pro R, and Sony Alpha 6000.All onboard components, including the flight controller, autopilot software, GNSS module, motors and ESCs, were selected to optimize stability and payload performance. A gimbal-free, downward-facing mount simplifies field deployment, while custom integration enables …

Functional Biopolymers Applied To Sustainable Technologies In The Environment And Healthcare, Fengjie He

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biodegradable polymeric materials (biopolymers) are naturally derived materials known for their excellent biocompatibility, biodegradability, sustainability, and versatile chemical functionality. They have attracted increasing attention in various applications as alternative to synthetic materials ranging from food packaging to tissue engineering. Meanwhile, with intrinsic advantages, biopolymers have also emerged as promising materials in addressing contemporary challenges in both biomedical and environmental fields. Motivated by the significant potential of biopolymers and the growing need for sustainable materials, my research focuses on the design and engineering of biodegradable polymers with novel modification methods and application directions. In this work, two representative biopolymers are selected: …

The Dual Impact Of Moral Injury: Links To Ptsd Symptoms And Disinhibited Externalizing In U.S. Combat Veterans, Bianca S. Islas

UNLV Theses, Dissertations, Professional Papers, and Capstones

Moral injury is an experience of psychological distress that occurs when a person’s morals are violated by themselves or others, including institutions and organizations. Such violations of morality can be impairing and have high rates of comorbidity with internalizing disorders (posttraumatic stress, depression, anxiety, suicidality), which may indicate that moral injury is a transdiagnostic construct. This study had four aims, which were accomplished using from a nationally representative, probability-based sample of 1,353 US military veterans. In the first aim, we created structural models of moral injury using the Moral Injury Events Scale (for which a bifactor structure with a specific …

Investigating Information Extraction And Language Models In Medical Domain Text Processing, Pouyan Nahed

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation demonstrates that carefully adapted language-model pipelines can transform unstructured clinical-trial and pharmacological prose into reliable, low-latency structured data. Four interconnected studies support this claim.Tri-AL platform. An open-source dashboard ingests all 440 k+ ClinicalTrials.gov records—including every historical revision—into a normalized schema and parses the 20 GB XML archive over 10x faster than a BeautifulSoup baseline, while exposing hooks for demographic analytics and supporting integration of user-defined modules. Clinical trial summarization. An encoder–decoder model is trained on 57k description–summary pairs to condense clinical trials into a few sentences. ROUGE evaluation shows a 20% improvement over the baseline, while graph-based evaluation …

Identifying Appropriate Clinical Cutoffs For Traumatic Dissociation In Maltreated Youth, Amanda L. Mraz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth who experience traumatic dissociation are at an increased risk for various severe psychopathological outcomes. Much is still unknown about the risk factors for traumatic dissociation in maltreated youth. The present study aimed to identify dissociation (e.g., dissociative amnesia, absorption and imaginative involvement, passive influence, and depersonalization and derealization) risk factors, via parametric statistical methods, in association with the appropriate clinical cutoff for the total and subscale scores from the Adolescent Dissociative Experiences Scale (A-DES). Investigatory variables included demographic (e.g., age, race, and gender), cognitive (e.g., resiliency and posttraumatic cognitions), and psychological (e.g., posttraumatic stress disorder, anxiety, and depression …

Pylro: A Python Calculator For Analyzing Long-Range Structural Order, Kevin Parrish

UNLV Theses, Dissertations, Professional Papers, and Capstones

We present PyLRO, an open-source Python calculator designed to detect, quantify, and display long-range order in periodic structures. The program’s design methodology, workflow, and approach to order quantification are thoroughly described and demonstrated using a simple toy model. Great care is considered in the detailing of the calculation logic, as is standard in the development of computational methods. Additionally, we apply PyLRO to a series of metastable AlPO4 structural intermediates from a prior high-pressure study, demonstrating how to compute and visualize structural order in all directions on a Miller sphere. We further highlight the program’s capabilities through a high-throughput analysis …

Tractors On The Mall: Unraveling The New Deal, Political Shifts, And The 1980s Farm Crisis, Tracy M. Neblina

UNLV Theses, Dissertations, Professional Papers, and Capstones

In the 1980s, Midwestern farmers faced an economic crisis that rivaled the Great Depression. Agricultural policy in the 1970s and 1980s led to a boom and bust for many of the nation’s farmers, causing the decline in rural communities in the middle of the country. During this period, more efficient agricultural production, shifting federal policy, high inflation, and devalued farmland led farmers in the Midwest to face incredible economic hardships, loss of land, changes in their communities, and challenges to their sense of purpose and identity. The Farm Crisis of the 1980s furnishes an extraordinary opportunity to investigate a confluence …

Nevada Hpv Vaccine Completion Time And Adherence Among 9-14-Year-Olds From 2017-2023, Emily Sandoval

UNLV Theses, Dissertations, Professional Papers, and Capstones

The HPV (Human Papillomavirus) is one of the most common sexually transmitted infections, in the United States. Since its development in 1991, the HPV vaccine has been proven to be highly effective against the infection (Centers for Disease Control and Prevention [CDC], 2024). In order for an individual to receive optimal protection, the CDC has given guidelines dependent on age. It is important to understand changes in HPV vaccine completion for future public health immunization campaigns and objectives. To analyze how HPV completion and adherence has changed from 2017-2023 among the 9-14-year-old population, a retrospective cohort study was conducted utilizing …

Development Of An Access Charge Framework For High-Speed Rail Incorporating Rail Replacement Costs And Dynamic Train Characteristics, Nitesh Kumar Yadav

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis develops a framework to determine track access charges for shared high-speed rail corridors, with a focus on rail replacement cost driven by train-induced loads. The method explicitly accounts for both static loads, resulting from axle weights, and dynamic loads that arise from train speed and track geometry, particularly curvature. Train characteristics such as axle load, operating speed, frequency of service, and number of wheels are integrated with track parameters, including curve radius, to calculate the total vertical load. These loads are used to estimate the cumulative tonnage threshold for rail replacement and the resulting service life of the …

Bio-Inspired Electroactive Polymer (Eap) Sensors For Surface And Canal Flow Sensing In Dynamic Environments, Nazanin Minaian

UNLV Theses, Dissertations, Professional Papers, and Capstones

Nature can often create some of the most efficient and elegant solutions to complex problems, and engineering stands to benefit greatly from these time-tested designs. One of the more sophisticated examples of this is the lateral line system in fish: a distributed network of superficial and canal neuromasts that enables aquatic species to detect fluid disturbances with remarkable precision. This dissertation leverages that biological framework to explore the potential of electroactive polymers (EAPs), aiming not just to replicate structure, but to emulate function.Two classes of EAPs form the basis of this work: electroactive plasticized polymer gels (EPPGs) and ionic polymer-metal …

Outcomes Of Patients With Newly Diagnosed Acute Myeloid Leukemia With Flt3-Tyrosine Kinase Domain Mutations: Prognostic Implications Of Npm1 Co-Mutation, Sankalp Arora, Wei-Ying Jen, Musa Yilmaz, Indraneel Deshmukh, Jayastu Senapati, Sanam Loghavi, Ghayas C Issa, Nicholas J Short, Tapan M Kadia, Courtney D Dinardo, Gautam Borthakur, Joseph Jabbour, Naveen Pemmaraju, Michael Andreeff, Koichi Takahashi, Kapil Bhalla, Uday Popat, Elizabeth J Shpall, Betul Oran, Hussein A Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Faculty, Staff and Student Publications

Background: The prognostic impact of Fms-like tyrosine kinase 3 (FLT3)-tyrosine kinase domain (TKD) mutation in patients with acute myeloid leukemia (AML) is not well defined. The authors described outcomes of one of the largest cohorts of patients with FLT3-TKD mutated (FLT3-TKDmut) AML to date.

Methods: This retrospective study included patients with newly diagnosed AML who received frontline treatment at The University of Texas MD Anderson Cancer Center from January 2012 to March 2024 divided into two cohorts: FLT3-TKDmut AML and nucleophosmin-mutated (NPM1mut)/FLT3-TKD wild-type (FLT3-TKDwt) AML. Patients with FLT3 internal tandem duplication mutations were excluded.

Results: In total, 2922 patients were …

Lipidomic And Proteomic Insights From Extracellular Vesicles In The Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes, Chioma M Okeoma, Wasifa Naushad, Bryson C Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira

Faculty, Staff and Student Publications

Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to reactive astrogliosis and chronic neuroinflammation, potentially mediated by the release of extracellular particles (EPs), such as extracellular condensates (ECs) and extracellular vesicles (EVs). These particles, which reflect the physiological, pathophysiological, and metabolic states of their cells of origin, might carry molecular signatures indicative of SUD. In particular, our study investigated neuroinflammatory signatures in SUD patients by isolating EVs from the dorsolateral prefrontal cortex (dlPFC) Brodmann's area 9 (BA9) from postmortem subjects. We isolated BA9-derived …

Evaluation Of The Antimicrobial Management Of Intracranial Suppurative Infections In A Single Pediatric Institution., Cameron E. Bizal, Alaina N. Burns, Rana El Feghaly, Brian R. Lee, Ann L. Wirtz

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To describe the antimicrobial management of and examine the etiology of intracranial suppurative infections (ISIs) at a single pediatric institution.

DESIGN: Retrospective review.

PATIENTS: We included children hospitalized at a 367-bed freestanding pediatric institution for treatment of an ISI (epidural or subdural empyema, brain abscess) between January 1, 2015, and September 30, 2023. ISIs were identified using international classification of diseases 9/10 discharge diagnosis codes.

METHODS: We collected data regarding patient characteristics, infection etiology and complications, antimicrobial choice and route (empiric, definitive, and outpatient), microbiology results, treatment duration, and treatment-related outcomes from the electronic health record.

RESULTS: A total …

Beyond Single Metrics: A Holistic Benchmarking Framework For Low-Power Embedded Systems, Hassan Adam

UNLV Theses, Dissertations, Professional Papers, and Capstones

Modern embedded systems encounter a notable challenge in evaluation. While devices may meet traditional benchmarks, they often underperform in real-world applications due to neglected interactions at the system level. Current benchmarking suites, such as MLPerf Tiny and EEMBC ULPMark, evaluate specific metrics including computational throughput, energy efficiency, and memory usage. However, they do not consider the complex interdependencies that affect real-world performance. This thesis presents a benchmarking framework that concurrently evaluates multiple performance dimensions under realistic workloads, revealing system behaviors that are often hidden in conventional benchmarks.Through the comprehensive evaluation of three representative algorithms: Fast Fourier Transform, quantized neural network …

Effects Of Body Armor On Respiratory Muscle Fatigue And Muscle Blood Flow During Progressive Treadmill Marching, Kathryn Bell

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Torso-borne loads such as body armor are essential for modern military operations but impose mechanical and metabolic strain. These physiological stressors can trigger the inspiratory metaboreflex, which redirects blood flow from locomotor to respiratory muscles, further reducing muscle oxygen and endurance. While aerobic fitness has been shown to alleviate these effects, the interaction between sex, aerobic capacity, and oxygenation under load is not well understood. This study examined the physiological effects of torso-borne load carriage on respiratory muscle fatigue, skeletal muscle oxygenation, and exercise performance to volitional exhaustion and the degree to which sex and aerobic capacity influence these …

Assessing The Impact Of Cdbg And Home Block Grants On Housing Affordability In The Las Vegas–Henderson–Paradise Metropolitan Statistical Area, David Hasan

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation aimed to analyze the impacts of aggregated federal funding from the CDBG and HOME block grants on temporal changes in the Housing Affordability Index (HAI Change). The temporal change in Housing Affordability between 2011–2015 and 2016–2020 was constructed as the dependent variable to measure the direct and indirect impacts of CDBG/HOME funding. Therefore, this dissertation seeks to identify the impacts of aggregated funding on changes in housing affordability and to explore spatial spillover effects through spatial dependencies that may influence housing affordability change as a dependent variable. The geographical area of this study is the Las Vegas–Henderson–Paradise MSA, …

Mechanisms Of Gold Enrichment In Seafloor Massive Sulfide Deposits: A Study On The Higashi-Aogashima Hydrothermal Field, Claudia Martinez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The study of Seafloor Massive Sulfides (SMS) deposit formation is vital for assessing both the economic potential and environmental risks posed by future marine mining projects. Metal-rich SMS deposits form in hydrothermal vent systems within tectonically active regions, such as back-arc basins, where faults enhance crustal permeability, enabling fluid migration driven by magmatic heat sources at depth in the crust. Currently our understanding of SMS formation processes is based on bulk-rock geochemical and isotopic data, lacking the necessary spatial and temporal resolution to understand ore forming processes. As a result, critical gaps remain in understanding the exact mechanisms responsible for …

Exploring The Processing Of Objects, Settings, And Global Properties In Natural Auditory Scenes, Margaret A. Mcmullin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Our auditory system has a remarkable ability to make sense of complex environments, allowing us to identify what we are hearing and where sounds come from. This process of auditory scene analysis is essential for situational awareness, decision-making, and effective communication in daily life. While much is known about how listeners segregate and identify individual sound sources (e.g., voices), less is understood about how global properties of a scene (e.g., openness, naturalness) contribute to perception. This dissertation examined how object- and setting-level information in natural auditory scenes are processed, and whether they rely on distinct or overlapping mechanisms. In Experiment …

The Dropbot: Design And Development Of A Custom Drone For Precision Water Drop Penetration Time (Wdpt) Testing, Mugundan Prakash

UNLV Theses, Dissertations, Professional Papers, and Capstones

Assessing the hydrophobic characteristics of soil is vital for understanding soil wettability or soil-water interactions, particularly in post-wildfire environments where water repellency can significantly impact ecosystem recovery, water infiltration, and erosion control. One key metric in soil wettability studies is the Water Drop Penetration Time (WDPT) test, which evaluates the hydrophobicity of soil and guides land treatment strategies. This thesis presents the design and development of DropBot, a custom-built drone platform engineered for the precise delivery and analysis of water droplets in WDPT tests.The DropBot, a custom drone, integrates a lightweight, 3D-printed frame with a self-leveling platform, enabling consistent droplet …

Randomised, Placebo-Controlled Trial Of Oral Hymecromone In Adults With Pulmonary Hypertension, Kathryn Czepiel, Nadine Nagy, Tamera Panjalingam, Anissa Kalinowski, Adam R Frymoyer, Harry Karmouty-Quintana, Bo Gu, Haley Hedlin, Gernot Kaber, Sylvie Dobrota Lai, Joelle I Rosser, Paul L Bollyky, Vinicio De Jesus Perez, Roham T Zamanian

Faculty, Staff and Student Publications

Background: Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and mortality. The extracellular matrix component hyaluronan (HA) is linked to vascular remodelling and interstitial fibrosis in PH. We hypothesised that inhibition of HA synthesis with hymecromone could serve as a reverse-remodelling therapy in PH.

Methods: We performed a proof-of-concept phase IIa randomised, double-blind, placebo-controlled study in adults with pulmonary arterial hypertension and PH associated with interstitial lung disease (PH-ILD). Patients were randomised to a 5:3 ratio and stratified by PH group to receive oral hymecromone or placebo two times per day over 24 weeks. The primary …

Mathematical Modeling And Association Analysis Decipher The Impact Of The Gut Microbiome On Cancer Immunotherapy, Andreas G Hadjigeorgiou, Constantinos Harkos, Aditya K Mishra, Golnaz Morad, Sarah B Johnson, Nadim J Ajami, Jennifer A Wargo, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

Faculty, Staff and Student Publications

The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunotherapy is needed to identify strategies to optimize outcomes. To this end, we developed a mathematical model to obtain insights into the effect of the microbiome on the immune system and immunotherapy response. This model was based on (i) gut microbiome data derived from preclinical studies, (ii) mathematical modeling of the antitumor immune response, (iii) association analysis of microbiome profiles with model-predicted immune profiles, and (iv) statistical models that correlate model parameters with …

Clinical, Tumor, And Product Features Associated With Outcomes After Axicabtagene Ciloleucel Therapy In Follicular Lymphoma, Soumya Poddar, Jiali Yan, Gayatri Tiwari, Darawan Rinchai, Justin Budka, Wangshu Zhang, Weixin Peng, Shruti Salunkhe, Madison Davis, Qinghua Song, Sara Beygi, Harry Miao, Mike Mattie, Rhine S Shen, Caron A Jacobson, Davide Bedognetti, Simone Filosto, Sattva S Neelapu

Faculty, Staff and Student Publications

Background: Axicabtagene ciloleucel (axi-cel), anti-CD19 chimeric antigen receptor (CAR) T cell therapy, demonstrated remarkable efficacy with manageable toxicity in relapsed/refractory indolent B cell lymphomas in the ZUMA-5 trial.

Methods:Here, we report associations of product attributes, serum biomarkers, clinical features, and tumor characteristics with outcome in 124 patients with follicular lymphoma (FL).

Results: In univariate and multivariate analyses, pretreatment inflammatory markers, including TNF-α and IL-12p40, as well as total metabolic tumor volume (TMTV), associated with disease progression. Conversely, T-naive–like product phenotype associated with improved outcome, particularly in patients with high TMTV. These covariates improved risk stratification when combined with the …

Contemporary Outcomes Of Octa-Nonagenarians With Newly Diagnosed Acute Myeloid Leukemia, Jayastu Senapati, Hagop M Kantarjian, Tapan M Kadia, Jeannot Kekedjian, Gautam Borthakur, Naval Daver, Courtney D Dinardo, Elias Jabbour, Prithviraj Bose, Nicholas J Short, Musa Yilmaz, Nitin Jain, Naveen Pemmaraju, Hussein A Abbas, Ghayas C Issa, Abhishek Maiti, Guillermo Montalban Bravo, Indraneel Deshmukh, Elizabeth Shpall, Partow Kebriaei, Uday Popat, Sanam Loghavi, Beenu Thakral, Guilin Tang, Fadi G Haddad, Yesid Alvarado, Guillermo Garcia Manero, Farhad Ravandi

Faculty, Staff and Student Publications

Background: Octa-nonagenarians with acute myeloid leukemia (AML) represent a high-risk group due to frequently poor performance status, adverse genomics (e.g., TP53 mutations, complex karyotype), a high incidence of secondary AML, and inability to undergo an allogeneic stem cell transplantation. Evaluating their outcomes with modern treatment approaches is important.

Methods: This retrospective study analyzed outcomes of patients ≥80 years old with newly diagnosed AML treated at our center from 2013-2023.

Results: A total of 289 patients (median age, 83 years; range, 80-95 years) were included. Venetoclax containing low-intensity therapy was administered to 107 patients (37.0%). AML subtypes included de novo (123, …

Morphological And Transcriptional Responses Of Mammalian Cells To Glucose Stress, Cassandra Burke

UNLV Theses, Dissertations, Professional Papers, and Capstones

Organismal cells encounter varying conditions, including daily and potentially seasonal fluctuations in available glucose. While some species tightly regulate circulating glucose levels, others tolerate extreme fluctuations, such as frugivorous bats experiencing post-prandial hyperglycemia and hibernating mammals maintaining stable glucose through torpor and hibernation. To investigate how these species-specific strategies influence cellular responses to glucose perturbation, primary dermal fibroblasts from nine mammals – humans, rats, Egyptian fruit bats, brown bear, 13-lined ground squirrel, little brown bat, gelada, honey badger, and Bactrian camel – were exposed to hypoglycemic (2.5mM), baseline (8mM), or hyperglycemic (30mM) treatment. Cell morphology was evaluated using Cell Painting, …