Digital Commons Network^™

Molecular Inflammatory Expression Profiles Associated With The Frequency Of Pain In Individuals With Sickle Cell Disease, Lana Mucalo Katunaric, Shuang Jia, Ashima Singh, Mark F. Roethle, Julie A. Panepinto, David C. Brousseau, Martin J. Hessner, Amanda M. Brandow

Department of Pediatrics Faculty Papers

Pain is the most common complication of sickle cell disease (SCD). The underlying biology of SCD pain is not well understood, which is a barrier to novel, effective analgesic and preventive therapies. A wide variability in the phenotypic expression of pain exists among individuals with SCD, despite the inheritance of a similar defective hemoglobin gene. This interindividual pain variability further complicates the ability to understand the biology and effectively treat pain. We sought to discover a biological signature comprising differentially expressed genes unique to SCD that could differentiate between individuals with varied pain frequency. We conducted plasma-induced transcription analysis from …

Evidence-Based Intervention Proposal For Reducing Intimate Partner Violence Against Jamaican Women, Kimisha K. Campbell

Walden Dissertations and Doctoral Studies

Domestic violence (DV) is a significant public health concern that negatively impacts women’s health, yet gaps in trauma-informed screening and referral processes persist within nursing practice. In Jamaica, DV remains underreported, highlighting the need for enhanced provider competency in identifying and supporting survivors. The doctoral project was used to examine how implementing the trauma-informed care (TIC) model and the Identification and Referral to Improve Safety (IRIS) program could improve healthcare staff’s ability to recognize, assess, and support DV survivors. Guided by the TIC framework and the IRIS program, a mixed-methods approach was used, incorporating pre- and posttraining assessments, staff surveys, …

Educating Health Care Workers To Reduce Stigma And Create A Supportive Environment For Individuals With Substance Use Disorder, Rosette Nakiyemba Wakanabo

Walden Dissertations and Doctoral Studies

This doctoral project was a staff education project aimed at addressing a critical practice problem within nursing related to stigma faced by individuals with substance use disorder (SUD) in health care settings. The practice-focused question guiding the project addressed whether structured education and skill building could reduce stigma among health care workers toward patients with SUD. The purpose of this project was to enhance health care workers’ understanding of stigma and to equip them with practical tools and strategies to foster inclusive, empathetic, and effective care environments. The training was delivered in a workshop format that combined evidence-based strategies with …

South Carolina Alternative Route Teacher Pipeline Report For 2023–24, Svetlana Dmitrieva, Brian Cartiff, Angela Starrett

Reports

This report presents a detailed analysis of South Carolina’s alternative route teacher workforce for the 2023–24 academic year, with a focus on preparation and retention. As part of SC TEACHER’s ongoing commitment to providing statewide educator workforce profiles, this publication, along with SC TEACHER’s broader research, offers timely, actionable data to inform educators, policymakers, and other stakeholders.

The findings presented here are based on educator-level data provided by the South Carolina Department of Education (SCDE) for 2023–24, along with longitudinal data from the 2019–20 through 2022–23 academic years. The 2023–24 analyses reflect a sample of 5,079 educators affiliated with state-approved …

Computational And Mathematical Modeling Of Microbial Community And Host Responses To Microbiota-Directed Complementary Foods Administered To Children With Acute Malnutrition., Steven J. Hartman

Arts & Sciences Graduate Student Theses and Dissertations

Globally, millions of children suffer from undernutrition, with stunting affecting 150 million and wasting nearly 50 million under five years old. Current interventions have shown limited effectiveness in mitigating long-term consequences such as stunted growth, cognitive deficits, and immune dysfunction. Through this body of work, I investigated the efficacy of a microbiota- directed complementary food (MDCF-2) as a next generation therapeutic food to combat childhood stunting. Across two randomized controlled trials involving Bangladeshi children with either moderate acute malnutrition or post-severe acute malnutrition, MDCF-2 significantly outperformed standard ready-to-use supplementary foods (RUSF), leading to significantly improved ponderal and sustained linear growth …

Understanding And Evaluating Genomic Language Models, Aadit Kapoor

Master's Theses

Large Language Models (LLMs) have shown remarkable capabilities in interpreting complex patterns across various domains, yet their application to genomic data remains limited. We see great potential in leveraging LLMs for vital biological tasks, such as predicting transcription factor binding sites and identifying antibiotic-resistant genes. This emergent behavior positions LLMs as powerful tools for enhancing our understanding of intricate biological language. LLMs trained specifically on genomic data, such as DNA sequences, operate distinctly compared to those trained on natural language. This difference is evident not only in the architectural landscape of the models but also in the methodologies employed by …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp): Bres No. 100 – Capri Motel – Arctic Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2025-08-12 Governance Committee Report, Morehead State University. Faculty Senate., Governance Committee.

Faculty Senate Records

Governance Committee report submitted to the Faculty Senate on August 12, 2025.

Some Properties Of Neutrosophic Cubic Hypersoft Sets, Lubna Nayab, Muhammad Gulistan, Fawad Hussain

Neutrosophic Systems with Applications

This study addresses the limitations of NCS in managing uncertainties associated with multiple attributes and their further bifurcation. To address this challenge, we propose a generalization of the neutrosophic cubic soft set, introducing the concept of "neutrosophic cubic hyper soft set." Within this framework, we define internal and external neutrosophic cubic hypersoft sets, along with operations such as P-intersection, P-union, P-restricted union, P-extended intersection, P-OR operator, P-AND operator, R-intersection, R-union, R-restricted union, R-extended intersection, R-OR operator, R-AND operator, complement, and relative complement of neutrosophic cubic hyper soft sets. The study explores and presents relevant results, demonstrating the enhanced capability of …

Application Of Multi-Criteria Decision Analysis For Quantifying Responsibility In Ml-Based Intrusion Detection System, Mona Mohamed, Zekra Sakr

Neutrosophic Systems with Applications

With the swift growth in Internet of Things (IoT), certifying secure and trustworthy networks has turned to be a critical challenge, particularly as IoT devices are increasingly vulnerable to sophisticated cyberattacks. As a remedy, intelligent intrusion detection systems (IDS) evolved as promising solutions in recent years, but deciding on the appropriate model remains difficult because of competing performance and trustworthiness criteria. To this end, this paper explores a novel application of an ML-augmented decision-making framework to enhance security-related decision-making in IoT environments. The framework systematically evaluates and ranks ML-based IDS systems according to different evaluation criteria with distinct trade-offs, including …

20250812: Jean Howard Smith Kittle And Stephen Kittle Student Collection, 1947-1976, Student Collections

Guides to University Archives

These items include materials from two students who attended Marshall (Jean Howard Smith Kittle & Stephen Kittle). Items were received in 2025 from Susan Norris (daughter to Jean and sister to Stephen). Within this collection includes a Marshall College Schedule of Courses, Curriculum Elementary Education, a test on the social norms of 1947, Parthenon student newspapers, Parthenon newspapers from the plane crash era and beyond, and select yearbooks. This is not an exhaustive list. Please download the finding aid for a full list of contents.

Extracellular Vesicles For Clinical Diagnostics: From Bulk Measurements To Single-Vesicle Analysis, Hai Linh Tran, Wenshu Zheng, David A Issadore, Hyungsoon Im, Yoon-Kyoung Cho, Yuanqing Zhang, Dingbin Liu, Yang Liu, Bo Li, Fei Liu, David Tai Wai Wong, Jiashu Sun, Kun Qian, Mei He, Meihua Wan, Yong Zeng, Ke Cheng, Tony Jun Huang, Daniel T Chiu, Luke P Lee, Lei Zheng, Andrew K Godwin, Raghu Kalluri, Steven A Soper, Tony Y Hu

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) play a crucial role in intercellular communication, signaling pathways, and disease pathogenesis by transporting biomolecules such as DNA, RNA, proteins, and lipids derived from their cells of origin, and they have demonstrated substantial potential in clinical applications. Their clinical significance underscores the need for sensitive methods to fully harness their diagnostic potential. In this comprehensive review, we explore EV heterogeneity related to biogenesis, structure, content, origin, sample type, and function roles; the use of EVs as disease biomarkers; and the evolving landscape of EV measurement for clinical diagnostics, highlighting the progression from bulk measurement to single vesicle …

2025-08-12 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from August 12, 2025.

Assessing The Muc5b Promoter Variant In A Large Cohort Of Systemic Sclerosis-Associated Interstitial Lung Disease, Carlos Rosa-Baez, Carlos Rangel-Pelaez, Inmaculada Rodriguez-Martin, Martin Kerick, Alfredo Guillen-Del-Castillo, Carmen P Simeon-Aznar, José Luis Callejas, Alexandre E Voskuyl, Alexander Kreuter, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Nicolas Hunzelmann, Jeska K De Vries-Bouwstra, Ariane L Herrick, Yannick Allanore, Lorenzo Beretta, Maureen D Mayes, Christopher P Denton, Shervin Assassi, Javier Martin, Marialbert Acosta-Herrera

Faculty, Staff and Student Publications

Objective: The common gain-of-function variant rs35705950, located in the promoter of MUC5B gene, has been strongly associated with interstitial lung diseases (ILDs) of different aetiology, such as idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis-associated ILD (RA-ILD). In this study, we aimed to investigate the association of this variant and its nearby single nucleotide polymorphisms (SNPs) in the largest cohort of systemic sclerosis-associated ILD (SSc-ILD) to date.

Methods: Samples were collected from blood/saliva, followed by DNA extraction and genotyping using SNP arrays. Data for rs35705950 and additional 903 variants within 100 Kb were obtained using genomic imputation. Subsequently, we tested their …

A Closer Look At Parental Narratives: A Qualitative Analysis Of Parental Entries In Neonatal Research Diaries Of Preterm Infants Participating In The Report-Bpd Feasibility Study, Wisam Muhsen, Ana Guillot Lozano, Jos M. Latour

School of Nursing and Midwifery

Highlights: What are the main findings? Parental diary entries captured meaningful real-time observations of preterm infants’ health during the first 10 days of life in the NICU. These entries showed emotional depth and parental vigilance but lacked the clinical specificity to support prediction of BPD. What is the implication of the main finding? Parental observations, while insightful, do not appear to complement echocardiographic data in predicting early BPD development. Neonatal diaries may still hold value as a communication tool to enhance family-centred care and parent–staff collaboration in the NICU. Background/Objectives: Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting preterm …

445 Bleecker Bh Llc V. Fausto Alejandro Jara Castro

All Decisions

In this non-payment case, the court granted the tenant's motion for summary judgment, dismissing the proceeding. Although the building predated C of O requirements, the court found that the landlord had illegally altered the building by creating additional apartments without the required permits. This action constituted a violation of Multiple Dwelling Law §§ 301 and 302, which prohibits a landlord from collecting rent or maintaining a non-payment action for an illegally occupied dwelling. Based on judicial notice of DOB and ECB violations, the court determined the landlord was barred from pursuing the action, resulting in a substantial win for the …

Pride-Ftg Advances Academic Careers Of Underrepresented Early-Stage Investigators Performing Blood Disorders Research, Betty S Pace, Oluwatoyosi A Onwuemene, Athena Starlard-Davenport, Rhea-Beth Markowitz, Vahé Heboyan, Petar Datsov, Treva Rice

2020-Current year OA Pubs

Despite improvements in the diversity of the US biomedical research workforce, individuals from different racial/ethnic groups remain underrepresented. Even though mentoring is critical for career advancement, underrepresented faculty have limited opportunities. Therefore, we evaluated a multipronged mentoring approach for early-stage underrepresented faculty trained in the Programs to Increase Diversity Among Individuals Engaged in Health-Related Research-Functional and Translational Genomics of Blood Disorders (PRIDE-FTG). The selection process involved a rigorous review of applications, considering factors such as academic potential, research interests, and commitment to diversity in biomedical research. This yearlong training experience includes 2 summer institutes consisting of lectures, grant-writing workshops, and …

Jefferson Et Al. Reply, Osmat Jefferson, W. Nicholson Price Ii, S. Sean Tu, Saurabh Vishnubhakat, Arti K. Rai

Articles

Notwithstanding Amgen’s strenuous objections, the core premise of our article should be uncontroversial to most policy analysts: biosimilar firms that simply want to manufacture an originator biologic in the manner it was manufactured at the time of US Food and Drug Administration (FDA) approval should be able to enter the market expeditiously once valid manufacturing (and other valid patents) that legitimately cover the ‘at approval’ biologic have expired. Our core premise relies on the widely accepted values of patent validity and notice. Instead of expensive litigation discovery fights over such ‘at approval’ issues, of the sort Amgen itself has spearheaded …

Larkspur Cut Flower Production In Utah, Nick Volesky, Melanie Stock

All Current Publications

Larkspur is an annual crop that provides vertical structure, height, and balance to floral arrangements. Stems also dry well, making them ideal for dried floral designs and other products. Paired with low input costs compared to many other flowers, larkspur is a competitive local crop for small farms. Utah State University (USU) trialed three colors for each Cannes, Fancy, and QIS^TM series (C. ajacis) in 2023 and 2024. This fact sheet covers site preparation, direct sowing and plant density, nutrient management, irrigation, pests and disease, harvest and storage, and economics.

Charting New Territory: Ai Applications In Dental Caries Detection From Panoramic Imaging., Man Hung, Daniel Yevseyevich, Milan Khazana, Connor Schwartz, Martin S. Lipsky

Institute on Aging Publications

Dental caries remains a public health concern, and early detection prevents its progression and complications. Panoramic radiographs are essential diagnostic tools, yet the interpretation of panoramic X-rays varies among practitioners. Artificial intelligence (AI) presents a promising approach to enhance diagnostic accuracy in detecting dental caries. This scoping review examines the current literature on the use of AI programs to analyze panoramic radiographs for the diagnosis of dental caries. This scoping review searched PubMed, Scopus, Web of Science, and Dentistry and Oral Sciences Source, adhering to PRISMA guidelines. The review included peer-reviewed, original research published in English that investigated the use …

Re: Approval Letter With Comments For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Annual Operations And Maintenance (O&M) Butte Treatment Lagoons (Btl) System 2024 (Dated May 30, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Bclaf1 Restrains Stress Responses In Hematopoietic Stem Cells To Support Expansion And Repopulation, Stephanie J Crowley, Wei Yang, Lynn S White, Jun Wu, Yanan Li, Haley Schmidt, Kyunghee Choi, Jeffrey A Magee, Jeffrey J Bednarski

2020-Current year OA Pubs

Hematopoietic stem cells (HSCs) rapidly expand during fetal development and after stress. Here, we identify B-cell lymphoma-2-associated factor 1 (BCLAF1) as a regulator of HSC repopulation activity, with roles in the expansion of fetal HSCs and hematopoietic reconstitution after stem cell transplantation. Using mice with hematopoietic-specific and inducible deletion of Bclaf1, we find that BCLAF1 promotes fetal HSC development but is dispensable for the maintenance of adult HSCs at steady state. Loss of BCLAF1 in either fetal or adult HSCs significantly impairs their self-renewal and multilineage reconstitution activity after stem cell transplantation. Single-cell RNA sequencing of fetal hematopoietic progenitors reveals …

Sliding Track Structure - Eco System, Hp Inc

Defensive Publications Series

This concept focuses on enhancing the reusability of laptop peripheral modules to reduce electronic waste and promote environmental sustainability.

Feature bricks by particular slide + Snap-on mechanical for quick and seamless connection and expansion.

Each individual module functions independently and can be freely combined with other modules to create entirely new functional products. Unlike fixed, rigid assemblies, this flexible design enables users to mix and match components according to their needs, fostering customization, reusability.

Analysis Of User Interaction Events For Conversion Matching Across Products, Ozgur Yonter, Arun Mathew, Alistair Hughes, Zhusong Li

Defensive Publications Series

Granular user interaction data can be used to guide product development, customize products per user preferences, and other purposes that can provide user benefits. However, it is difficult to efficiently aggregate and compare user interaction data from multiple different products and across different data dimensions in a privacy-preserving manner. This disclosure describes privacy-compliant techniques that generate insights into user behavior by analyzing user journeys cross-contextually across diverse products (including interaction via different modalities and user interfaces). Per the techniques, a conversion matching service (CMS) is built that offers flexibility in defining join algorithms that can be used for attribution. User-permitted …

Compact Battery Design With Adjustable Weight Distribution For Wearable Devices, Shengyin Ding, Yuchu He

Defensive Publications Series

Smart glasses integrate a number of energy-consuming elements. Providing battery cells to power these components while also enabling adequate battery life can result in designs that are heavy and uncomfortable. An important factor related to comfort is the weight distribution and center of gravity of the device. This disclosure describes techniques to tune the center of gravity of smart glasses by adjusting the distribution of battery cells across the structure of the glasses. Battery cells are arranged in a stacked configuration, with each cell sized and shaped according to the space available at its location. The distribution of battery-stack layers …

Dynamic Drop Targets For Browser Tab Management, Theodore Nicholas Choc, Armina Foroughi-Shafiei

Defensive Publications Series

Browser tabs can be moved with relative ease from one window to another on the same device. However, moving tabs between devices is a multi-step operation that requires the navigation of multiple menus. Also, moving tabs from the tab management surface to other areas of the browser such as bookmarks, reading lists, or for sharing with other users, can be complicated, requiring multiple operations by the user. This disclosure describes techniques to streamline browser tab management by automatically surfacing dynamic drop targets during a tab drag-and-drop operation. The drop targets correspond to various contextually relevant locations or functional actions. Examples …

Open Void-Fab Stack: Holo-Atomic Micro-G Printing, Real-Time Di!Ractive Ai, And Nano-Plasma Patch-Healing, Xavier Pillet

Defensive Publications Series

This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). This work discloses enabling concepts for orbital fabrication and in-situ repair: holo-atomic micro-g printing, real-time diffractive AI control, and a nano-plasma Patch-Healer torch, plus 12+ hybrid …

Longevity Os: Open Compendium Of Aging Biomarkers And Open-Source Intervention Protocols, Xavier Pillet

Defensive Publications Series

This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). We disclose 77 enabling embodiments spanning assays/kits (telomeres, DNAm clocks, glycan-age, proteome, microbiome, metabolome, cfDNA-CHIP, mtDNA, 8-oxo-Gsn, NAD⁺), devices/sensors (AGE autofluorescence, VOP/PPG, continuous/interstitial NAD), …

Regenerative Planet: Open-Source Catalog Of Trl 3–9 Technologies For Climate Resilience And Biodiversity Restoration – 2025 Edition, Xavier Pillet

Defensive Publications Series

This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) covering thirty implementable innovations spanning devices, materials, processes, control algorithms, MRV stacks, and system integrations for climate resilience and biodiversity restoration. By public disclosure, it enters the state of the art under the applicable patent statutes : EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). …

Equalitarian Dao V1.0 — Technical Specification & Source Code, Xavier Pillet

Defensive Publications Series

This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). This work discloses 48 enabling proposals across L1/L2 consensus and PQC (Stake & People 50/50, tree-signatures), fiscal protocols (polynomial rebase with ZK proof-of-execution), DeFi …