Digital Commons Network^™

Computer-Aided Reading Of Chest Radiographs For Paediatric Tuberculosis: Current Status And Future Directions, Mackenzie Dupont, Robert Castro, Sandra V Kik, Megan Palmer, James A Seddon, Devan Jaganath

Faculty, Staff and Students Publications

Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently the only adjunctive tool for clinical assessment in the evaluation of paediatric tuberculosis in primary care settings, and children would benefit from CAD models that can detect their unique clinical and radiographic features. To advance CAD for childhood tuberculosis, large, diverse paediatric CXR datasets linked to standardised tuberculosis classifications are required. These datasets would be used to train and validate paediatric-specific models for tuberculosis screening, diagnosis, and severity stratification. Previous studies …

Influenza-Associated Acute Necrotizing Encephalopathy In Us Children, Andrew Silverman, Rachel Walsh, Jonathan D Santoro, Katherine Thomas, Elizabeth Ballinger, Kristen S Fisher, Ajay X Thomas, Brian Appavu, Michael C Kruer, Derek Neilson, Jasmine Knoll, April N Sharp, Hannah E Edelman, Scott Otallah, Alexandra Morgan, Aniela Grzezulkowska, John Nguyen, Lekha M Rao, Shaina M Hecht, Laura Catalano, Hunter Daigle, Catherine Kronfol, Jessica Wharton, David Adams, Adam Z Kalawi, Michael Kung, Janetta L Arellano, Lauren Smith, Devorah Segal, Kristina Feja, Eileen Broomall, Anuj Jayakar, Sandra R Arnold, Hanna Retallack, Craig A Press, Grace Gombolay, Madeleine H Mclaughlin, Varun Kannan, Kavita Thakkar, Tasmia Rezwan, Erin Hulfish, Dalia Eid, Jennifer Meylor, Diane Peng, Ryan Hurtado, Taylor Nickerson, Iris Mandell, Abigail U Carbonell, Mallory Kerner-Rossi, Divya Jayaraman, Mallory Davis, Rosemary Olivero, Neel Shah, Christina M Osborne, Bo Zhang, Christopher Cortina, Adrienne G Randolph, Suchitra Rao, Thomas Larocca, Keith P Van Haren, Molly Wilson-Murphy

Faculty, Staff and Students Publications

Importance: Acute necrotizing encephalopathy (ANE) is a rare, but severe, neurologic condition for which epidemiologic and management data remain limited. During the 2024-2025 US influenza season, clinicians at large pediatric centers anecdotally reported an increased number of children with influenza-associated ANE, prompting this national investigation.

Objective: To understand the clinical presentation, interventions, and outcomes among US children diagnosed with influenza-associated ANE.

Design, setting, and participants: This study was a multicenter case series of children diagnosed with ANE with longitudinal follow-up. A call for cases was issued via academic societies, public health agencies, and by directly contacting pediatric specialists at 76 …

Multiplex Imaging Mass Cytometry Reveals Prognostic Immunosuppressive Subpopulations And Macrophage-Driven Metastasis In Osteosarcoma, Benjamin B Gyau, Junyan Wang, Weiguo Wu, Brooks Scull, Angela M Major, Weidong Jin, Justin M M Cates, John Hicks, Tsz-Kwong Man

Faculty, Staff and Students Publications

Osteosarcoma is a type of bone cancer that mostly affects kids and teens. The biggest danger is when the cancer spreads to the lungs, and current treatments do not work well for those cases. Immunotherapy, which helps the body’s immune system fight cancer, has worked for other cancers but is limited for osteosarcoma because we do not fully understand the environment around the tumor. Our research looked at various cells around the tumor to study why patients have worse outcomes. We found that certain cells, called M2 macrophages (M2) and myeloid-derived suppressor cells (MDSC), which weaken the immune system, are …

High-Speed Voltage Imaging Of Action Potentials In Molecular Layer Interneurons Reveals Sensory-Driven Synchrony That Augments Movement, Spencer T Brown, Meghana R Holla, Michelle A Land, Shuyuan Yang, Alex J Mcdonald, François St-Pierre, Indira M Raman

Faculty, Staff and Students Publications

Testing whether the synchrony of action potential firing is a cerebellar coding mechanism requires simultaneous recording, with high temporal fidelity, from populations of identified neurons. Here, we used targeted one-photon voltage imaging at 2–4 kHz to record action potentials from groups of ~10–300 molecular layer interneurons (MLIs) expressing a positively tuned, genetically encoded voltage indicator, FORCE1f or pAce. In awake resting mice, crus I MLIs fired brief (~1-ms) spikes at 20–60 spikes/s. Sensory stimuli of air puffs to the whiskers evoked short-latency (< 10 ms) increases in spiking probability. In most trials, >50% of MLIs fired synchronously with 4-ms temporal precision. The magnitude of puff-evoked whisks correlated tightly with …

Cathartocytosis: Jettisoning Of Cellular Material During Reprogramming Of Differentiated Cells, Jeffrey W Brown, Xiaobo Lin, Gabriel Anthony Nicolazzi, Xuemei Liu, Thanh Nguyen, Megan D Radyk, Joseph Burclaff, Jason C Mills

Faculty, Staff and Students Publications

Injury causes differentiated cells to undergo massive reprogramming to become proliferative and repair tissue via paligenosis. Gastric chief cells use paligenosis to reprogram into progenitor-like spasmolytic-polypeptide-expressing metaplasia (SPEM) cells. Stage 1 of paligenosis is the downscaling of mature cell architecture via a process involving lysosomes. Here, we notice that sulfated glycoproteins are not only digested during paligenosis but also excreted into the gland. Various genetic and pharmacological approaches show that endoplasmic reticulum membranes and secretory granule cargo are also excreted and that the process proceeds in parallel with but is mechanistically independent of autophagy. Three-dimensional light and electron microscopy demonstrated …

Quantum Pseudorandom Primitives Beyond Pseudorandom States, Chuhan Lu

Dissertations and Theses

Quantum pseudorandomness is an emerging research area. Ji, Liu, and Song defined pseudorandom states (PRSs) and pseudorandom unitaries (PRUs) as quantum analogs of pseudorandom generators and pseudorandom functions. A unitary oracle separation result between one-way functions and PRSs/PRUs, established by Kretschmer, suggests that certain quantum primitives may remain secure even if classical cryptography is compromised. This insight has spurred extensive work on quantum pseudorandomness and its applications in quantum cryptography.

Many constructions of PRSs have been established under standard assumptions, yet building a secure PRU was a long-standing open problem. This dissertation aims to narrow the gap between PRSs and …

The Problem Of Market Power In Postwar America: Antitrust Law, Regulatory Discourse, And Changing Ideas Of Market Power, Laura Phillips-Sawyer

Scholarly Works

US antitrust law prohibits anticompetitive restraints of trade, including collusion among firms and single-firm monopolization. The law serves as a democratic check against concentrations of private economic power. However, in the post-World War II era, the law has changed largely through case law, rather than through statutory interventions. Thus, understanding the role that antitrust law has played in reconciling capitalism and democracy requires us to ask what has influenced changes to antitrust law. This chapter traces antitrust law’s postwar development across three key periods: 1940–1970s, mid-1970s to 2010s, and 2010s to present. It argues that each era’s approach to the …

Artificial Intelligence In Ocular Transcriptomics: Applications Of Unsupervised And Supervised Learning, Catherine Lalman, Yimin Yang, Janice L. Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Transcriptomic profiling is a powerful tool for dissecting the cellular and molecular complexity of ocular tissues, providing insights into retinal development, corneal disease, macular degeneration, and glaucoma. With the expansion of microarray, bulk RNA sequencing (RNA-seq), and single-cell RNA-seq technologies, artificial intelligence (AI) has emerged as a key strategy for analyzing high-dimensional gene expression data. This review synthesizes AI-enabled transcriptomic studies in ophthalmology from 2019 to 2025, highlighting how supervised and unsupervised machine learning (ML) methods have advanced biomarker discovery, cell type classification, and eye development and ocular disease modeling. Here, we discuss unsupervised techniques, such as principal component analysis …

Re: Approval Letter For Bpsou Blacktail Creek Riparian Actions Draft Field Work Plan: Wetlands Delineation And Functional Assessment (Received August 8, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: 2025 Spring Migration Seasonal Report For Berkeley Pit Waterfowl Protection Plan, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Strategies To Implement Employee Cybersecurity Awareness Programs, Felix Ngwese

Walden Dissertations and Doctoral Studies

Lack of cybersecurity awareness among employees and end-users poses significant risks to organizations. This issue is critical because inadequate cybersecurity awareness increases organizational vulnerabilities, leading to financial losses and compromised data security. Grounded in the routine activity theory, the purpose of this qualitative multiple case study was to explore strategies that IT security managers had implemented to enhance employee cybersecurity awareness. The participants were six IT security managers in Cameroon, West Africa, with strategies to implement employee cybersecurity awareness. Data were collected using semistructure interviews and a review of documents. Through thematic analysis, three themes were identified: (a) cybersecurity awareness …

Leadership In Action: Enhancing Staff Development For Organizational Success, Reinaldo Rivera Hernández

Walden Dissertations and Doctoral Studies

Nonprofit organizations face distinctive challenges that require specialized leadership and effective staff development strategies, particularly in community-focused organizations in Lancaster, Pennsylvania. Leadership deficiencies can diminish employee commitment, restrict professional growth, and weaken organizational capacity, ultimately limiting mission fulfillment. The purpose of this qualitative study was to explore leadership and staff development deficiencies within a nonprofit organization in Lancaster County and identify strategies for improvement. Guided by Kurt Lewin’s change management model, the study examined barriers and supports for professional growth, the influence of leadership on organizational culture and retention, and practices promoting equity and succession planning. Semi-structured interviews were conducted …

New Window To The Universe: Researcher To Study Gravitational Waves, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Sifting through the noise of space is no easy task, even for astrophysicists. But a new grant from the National Science Foundation promises to help a University of Mississippi researcher decode the sounds of the universe.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Understanding The Relationship Between The Crystal Structure Elastic-Plastic Properties Of Discrete-Molecule Organic-Inorganic Halide Perovskites, Jacob L. Hempel, Michael D. Wells, Sean Parkin, Yang Tse Cheng, Aron J. Huckaba

Chemistry Faculty Publications

Discrete-molecule hybrid perovskites with different organic and inorganic molecules can provide a wide array of tunable optoelectronic and piezoelectronic properties. In this study, we report the elastic modulus and hardness, obtained from instrumented indentation measurements, of three new and three known discrete-molecule single crystal halide metalates, with an aim towards understanding the relationship between their microstructure and mechanical properties. We find a correlation in the mechanical properties and the density of the crystal structure, as well as with the number of hydrogen bonding sites available on the organic cation. These two observations suggest that denser crystal structures with more hydrogen …

Segmental Atrophy Of The Liver: Review Of A Rare Pseudotumor, Ayesha Younus, Yu Liu, Ellen E. Connor, Zeng-Ying Wu, Hwajeong Lee, Zhi-Yan Fu

School of Medicine Faculty Publications

Segmental atrophy (SA) of the liver is a rare, often underrecognized, benign condition that presents as a mass lesion, mimicking a neoplasm, which poses a significant diagnostic challenge. Given its rarity, only a limited number of case reports and series have been published, resulting in sparse literature on the entity. This review aims to summarize the clinicopathologic and diagnostic features of SA and thus improve its recognition.

Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2016, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Using 2016 weather data, we ran PySAM power production simulations for utility-scale PV sites in the U.S. Eastern Interconnection queue. Site IDs, capacities, and locations (counties) were extracted from Lawrence Berkeley National Laboratory's Queued Up: 2024 Edition dataset. No panel mount information was provided, so all sites were assumed to be the centers of the installation counties. See queued_site_metadata.csv file for individual site metadata

Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2018, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Using 2018 weather data, we ran PySAM power production simulations for utility-scale PV sites in the U.S. Eastern Interconnection queue. Site IDs, capacities, and locations (counties) were extracted from Lawrence Berkeley National Laboratory's Queued Up: 2024 Edition dataset. No panel mount information was provided, so all sites were assumed to be the centers of the installation counties. See queued_site_metadata.csv file for individual site metadata

Hourly Simulated Power Production Data With Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2013, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2013. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2013_PV_existing_site_metadata.csv file for individual site metadata.

Hourly Simulated Power Production Data With Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2014, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2014. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2014_PV_existing_site_metadata.csv file for individual site metadata.

Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2015, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2015. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2015_PV_existing_site_metadata.csv file for individual site metadata.

Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2016, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2016. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2016_PV_existing_site_metadata.csv file for individual site metadata.

Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2019, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2019. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2019_PV_existing_site_metadata.csv file for individual site metadata.

Student Life E-Newsletter August 26, 2025, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Ifit3 Activation Significantly Contributes To Hiv-1-Associated Neurodegenerative Disorder-Mediated Neuroinflammation, Ranjit Kumar Das, Nirakar Sahoo, Deepa Roy, Chun Xu, Jose Galarza, Maria Camila Mejia Garza, Hansapani Rodrigo, Asim K. Duttaroy, Upal Roy

Health & Biomedical Sciences Faculty Publications

Introduction: The advent of effective combination antiretroviral therapy (cART) has significantly improved HIV-1 treatment, saving millions of lives. However, HAND remains a concern, particularly among aging individuals with HIV-1. The mechanisms underlying HAND are not well understood.

Methods: This study investigated the role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and its upstream regulator, signal transducer, and activator of transcription 1 (STAT1), in HAND pathology. Using the SH-SY5Y neuroblastoma cell line and HIV-infected humanized mice, we examined the effects of the cART drugs, HIV Tat protein, and HIV-1 virus on STAT1 and IFIT3 expression.

Results: The results showed that …

Partner Collective Impact Survey Final Evaluation Report, Courtney A. Fitzgerald, Theresa H. Cruz, Havana Maisano

Reports & Documents

The Healthy Here coalition, based in Bernalillo and Santa Fe Counties, brings together over 30 organizations working across four key areas: healthy eating, active living, family healthy weight, and vaccinations. In summer 2025, the coalition conducted a PARTNER Collective Impact Survey to evaluate its network structure, contributions, and effectiveness. The survey, completed by 29 organizations (87.9% response rate), provided insights into how member organizations collaborate, the resources they contribute, and how trust and value are perceived across the network.

Findings show that coalition members most frequently contributed community connections, content expertise, and information sharing, with Presbyterian Community Health and the …

Investigation Of Co-Current And Counter-Current Multiphase Flow In Upstream Drilling And Production Applications, Hazem Fleifel

LSU Doctoral Dissertations

In the domain of upstream Petroleum Engineering, the dynamics of co-current and counter-current multiphase flows present huge challenges, significantly impacting the efficiency of associated processes. This study investigates two specific applications concerning these flow behaviors, involving both laboratory experiments and transient computer simulations. This work investigates two distinct well control and production enhancement processes, involving multiphase flow dynamics: the bullheading kill procedure and liquid-assisted gas lift (LAGL).

The first topic (Topic 1) explores the bullheading process, a type of well control methods, by challenging the traditional understanding that gas removal efficiency increases monotonically with injection pump flow rate. Through 1D …

Choice Of Animal Models To Investigate Cell Migration And Invasion In Glioblastoma., Piyanka Hettiarachchi, Taeju Park

Manuscripts, Articles, Book Chapters and Other Papers

Glioblastoma is an aggressive and prevalent form of brain cancer characterized by rapid tumor cell migration and invasion into surrounding healthy tissues, making it resistant to conventional treatments. Despite advances in therapeutic approaches, patient prognosis remains poor, with a median survival of approximately 15 months. Tumor cell infiltration along perivascular spaces and white matter tracts is a major driver of recurrence, underscoring the need for experimental models that accurately capture these invasive behaviors. Animal models remain indispensable for this purpose, offering insights that cannot be fully replicated in vitro. This review focuses on applying animal models to elucidate the mechanisms …

Facpaac Minutes 08/26/2025, Faculty And P&A Affairs Committee

Faculty and P&A Affairs Committee

No abstract provided.

First Permanent Molar Root Canal Configurations In A South African Sample: A Descriptive Micro-Computed Tomographic Report, Casper Jonker, Guy Lambourn, Peet Van Der Vyver, Theye Charlotte, Federico Foschi, Ericka Noelle L’Abbé, Anna Catherina Oettlé

Peninsula Dental School

The aim of this paper was to describe root canal configurations using micro-CT in South African first molars. A segmentation process was followed on micro-focus X-ray computed tomography (micro-CT) scans of 101 maxillary and 86 mandibular first molars. Main and accessory root canal anatomy were considered to describe root canal configurations of South African first molars. Intra- and inter-observer reliability was determined using the unweighted Cohen’s Kappa test. Intra- and inter-rater agreement was 93% for maxillary configurations; 92.9% and 86.2% respectively for mandibular configurations. The most common main canal configurations were: 3MXFM MB1DB1P1 (n = 33/93, 35.5%) and 2MDFM M1-2D1 …