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Caldwell Leqembi Home‑Safety & Support Engine (Clhse‑1.0) Unified Open‑Hardware Architecture Integrating Cudre‑1.0, Cng‑Loop V1.0, Cinhrs, Becds V2.0, Accs V4.0, And Caregiver/Clinic Integration Enhancements, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract

CLHSE‑1.0 is a unified, open‑hardware support architecture designed for patients receiving FDA‑approved LEQEMBI IQLIK (subcutaneous lecanemab‑irmb) for early Alzheimer’s disease. The system integrates five existing Caldwell inventions, each posted on the TDC site, and adds a caregiver micro‑dashboard, clinic integration packet, and minimal hardware starter kit to increase real‑world viability and testing potential.

CLHSE‑1.0 provides a non‑clinical safety and monitoring envelope around LEQEMBI IQLIK’s at‑home dosing model, addressing ARIA‑E/ARIA‑H symptom detection, injection‑reaction monitoring, neurologic changes, sleep‑linked deterioration, caregiver workflow, and functional decline tracking aligned with CDR‑SB domains.

CLHSE‑1.0 does not modify lecanemab, its dosing, its pharmacology, or its FDA‑approved …

Polymer Production From Biogenic Feedstocks, Natalie M. Durdle Miss

Defensive Publications Series

1. This document outlines a standardized, closed-loop biological framework for manufacturing high-tensile structural fibers capable of supporting high-altitude or orbital infrastructure. The pipeline eliminates the requirement for traditional heavy industrial refinery infrastructure by utilizing a re-engineered multi-organism bacterial substrate. Through co-cultured metabolic pathways, engineered microorganisms systematically convert base carbon inputs into volatile propane and ammonia gases. These gases are captured, reacted via ammoxidation, and carbonized to generate advanced carbon-fiber matrices suitable for aerospace tether deployments.

Pipeline For Llm Refinement With Expert Routing, Consensus, And Impact Attribution, Saloni Priya

Defensive Publications Series

Systems and methods can refine LLM outputs through a pipeline architecture that integrates human expert feedback. This pipeline may feature a dynamic routing engine to assign detected errors to qualified experts, an adaptive quality-weighted consensus engine to validate proposed corrections, and an impact attribution engine to measure the value of contributions. These components can operate in a feedback loop to identify, correct, and reintegrate validated knowledge. This process can be used to ground future LLM generations with curated information, potentially affecting the factual accuracy and reliability of model outputs in a scalable manner.

Reactive Mid-Session Expansion Of A Multi-Agent Large-Language-Model Team Under Bounded Admission And Guaranteed-Termination Phase Constraints, With Cross-Session Agent Reincarnation, Antonio Gallego Sáez, Juan Cazila

Defensive Publications Series

In the context of multi-agent artificial intelligence (AI) environments in which a supervisor large language model (LLM) agent participates in a bounded collaborative reasoning session alongside a pre-declared team of specialist LLM agents, a system is proposed herein that dynamically spawns agents on demand by allowing the supervisor LLM agent to emit structured spawn directives during selected phases of a session. The team of specialist LLM agents can thereby expand in response to domain gaps discovered during the session while remaining subject to bounded-admission and guaranteed-termination constraints.

Process For Preparation Of Ensifentrine, Anonymous

Defensive Publications Series

Based on known literature, a reaction scheme was designed for the preparation of Ensifentrine and the same was carried out in lab and commercial scale as well, to achieve consistently high yield and purity of the API.

Policy-Graph Audit Method For Algorithmic Collusion Detection In Multi-Agent Pricing Systems, Anonymous

Defensive Publications Series

A computer-implemented audit evaluates collusion risk in multi-agent reinforcement-learning pricing systems by analyzing the full counterfactual structure of trained policies rather than only observed price traces. Trained policies are frozen into deterministic greedy action mappings over a discrete joint market state space. A deterministic successor mapping is computed for each joint state to form a directed functional graph with one outgoing edge per state. The graph is decomposed into attractor cycles and basins of attraction that partition the state space. Each attractor is assigned an elevation score based on mean cycle price relative to reference Nash and joint-profit-maximizing price levels, …

Integrated System For Parallel Codebook Generation Via Discrete Flow Matching With Latent-Compressed Encoder States And Fused Gpu Kernel Execution, Anonymous

Defensive Publications Series

Systems and methods generate multi-codebook semantic identifiers for generative retrieval using parallel discrete flow matching, latent-compressed encoder conditioning, and fused GPU execution. A user context is encoded to an encoder representation E, which is compressed to a latent-compressed encoder state cKV = E * Wdown with dc << D. N candidate discrete states over K codebooks are initialized from noise and iteratively denoised for T steps, updating all K codebook positions in parallel according to per-codebook schedules sigma_k(t) = t^{alpha_k} with learnable alpha_k. Cross-attention conditioning is computed over cKV using absorbed projection operations. Flow updates and candidate scoring execute within a single fused GPU kernel launch that may be persistent, retaining cKV in on-chip cache across steps and selecting top-n outputs.

Power-Efficient Packet Aggregation For Wireless Radio During Low-Power Processor Data Offload Via Throughput-Mismatched Interface, Anonymous

Defensive Publications Series

A wireless radio buffers packets received from a low-power processor over a lower-throughput host interface while keeping radio-frequency (RF) hardware in a low-power state. Firmware on the wireless radio detects a first packet arrival and starts a single-shot aggregation timer. Subsequent packets received during the timer interval are accumulated in a local buffer without powering the RF hardware. When the timer expires, the firmware activates RF circuitry and transmits the accumulated packets as a high-throughput over-the-air burst. After the burst, the aggregation timer is not re-armed, allowing later packets to be transmitted without added aggregation delay. The timer duration may …

Vertebrate Diversity In Cave Systems Of Colombia: An Approach Based On Environmental Dna Metabarcoding Analysis, Rita Daniela Martinelli Marín, Carlos Andres Lasso, Francesco Sauro, Susana Josefina Caballero

International Journal of Speleology

There is currently limited knowledge of the biological communities inhabiting cave ecosystems in South America. This study examines the vertebrate community composition of 21 caves across diverse subterranean ecosystems in Colombia using environmental DNA (eDNA) analysis. Water was collected from water bodies inside caves and subterranean systems in six of the eight speleological regions of Colombia in eight departments. Water was filtered manually through a 0.8 m pore size filter and preserved with Longmire solution. A 170-base pair (bp) fragment of the 12s mitochondrial gene specific for vertebrate identification was amplified by PCR and sequenced by Illumina (metabarcoding). Data corresponding …

Origami Sake: Building A Sustainable Supply Chain For A New Beverage Startup, Akosua Sayer Koduah, Nick E. Johnston

ICHRIE Research Reports

Sustainability has become a strategic pillar in the hospitality and beverage industry, shaping supply chain decisions, consumer behavior, and market competitiveness. This study examines how Origami Sake, a startup brewery in Hot Springs, Arkansas, integrates sustainability into its supply chain from inception. Using qualitative analysis of company interviews, secondary data, and comparative literature, the study shows that Origami Sake embeds renewable energy, localized rice sourcing, and by-product reuse into its core operations. These practices reflect circular economy principles and strengthen regional identity, yet they also pose challenges related to packaging limitations, organic rice availability, data-tracking gaps, and the risks of …

Are Hotels Ready For Flooding? Improving Employee Preparedness, Ahmin Kwon, Marketa Kubickova, Swechchha Subedi

ICHRIE Research Reports

Focusing on the experiences of 500 current hotel employees in the United States, this report evaluates current levels of flood preparedness and the role of organizational support in shaping employee proactive response. Findings indicate that most employees have experience with flooding and rely on multiple information sources, yet trust in government response remains moderate. Clear disparities emerge across hotel segments, with significantly higher preparedness commitment and proactive behavior among employees in luxury hotels and those with longer tenure. Importantly, prior experience does not necessarily translate into effective preparedness. Although many respondents perceive existing information as sufficient, there is a continued …

Exploring Hotel Sustainability Through A Service Design Lens: An Espoused Theory Vs. Theory-In-Use Perspective, Cindy Yoonjoung Heo, Jaehyun Park, Sanqi Yang, Chen Ni, Lei Tang, Lei Yu, Julneth Rogenhofer, Geraldine Assen

ICHRIE Research Reports

Sustainability is now widely embedded in hotel strategies, but it is often assessed through what hotels communicate rather than what guests actually experience. This study examines that disconnect by drawing on Argyris and Schön’s distinction between espoused theory and theory-in-use, combined with a service design perspective. Using document analysis alongside in-situ observations at the front desk and in guest rooms, the study looks at how sustainability appears across service touchpoints and whether it is likely to be noticed and understood by guests. The findings suggest that many initiatives are operationally in place but remain largely out of sight during the …

Aviation Disruptions And Tourism Resilience: Policy Lessons From The Indigo 2025 Crisis For India’S Hospitality Tourism Sector, Ann Mary Varghese, Vijaya Zinnoury

ICHRIE Research Reports

The December 2025 IndiGo flight disruption crisis, characterized by widespread cancellations, delays, and capacity constraints, significantly impacted India’s tourism and hospitality sectors during peak travel periods. This research report examines the cascading effects of aviation instability on tourism demand, hotel occupancy, pricing dynamics, and regional economies. Drawing on secondary data from industry reports, news coverage, and policy analyses, the study identifies systemic vulnerabilities in India’s aviation–tourism nexus. Findings indicate that flight disruptions led to large-scale hotel cancellations, revenue losses, and demand volatility, particularly in destination-dependent regions in India such as Darjeeling, Rajasthan, and Uttarakhand. The report further evaluates industry responses, …

Tourism System Fragility: Evidence From The Middle East War, Ann Mary Varghese, Vijaya Zinnoury

ICHRIE Research Reports

The ongoing Middle East conflict (2026) has triggered one of the most significant global aviation disruptions since the COVID-19 pandemic, with widespread airspace closures, flight cancellations, rerouting, and fuel cost escalation affecting airlines worldwide. This research report examines how conflict-driven aviation instability has impacted tourism demand, hospitality performance, and destination economies.

Drawing on real-time global evidence, the study finds that the closure of critical air corridors across the Middle East, which handle approximately 15% of global air traffic, led to thousands of daily flight cancellations, mass rerouting, and substantial cost increases for airlines. These disruptions propagated across tourism systems, reducing …

Campus Food Recovery: Balancing Sustainability And Student Needs, Scott T. Taylor Jr., Wenhao Zhang, Robin B. Dipietro, Mary Stein, Junehee Kwon

ICHRIE Research Reports

The purpose of this study was to assess the impact of a food recovery program at a large university on food waste reduction and food insecurity mitigation. The primary goal of the food recovery program was two-fold: to help provide ready-to-eat meals for students facing food insecurity and to help the campus food service provider minimize post-production food waste. Thus, food was recovered from multiple dining outlets on a large university campus in the southeast United States. To ensure a valid comparison between 2022-2023 and 2023-2024 academic years, a 3-month period during the spring semesters in 2023 and 2024 was …

Robot Ready, Deploying Semi-Autonomous Food Delivery Robots, Betsy Bender Stringam, Somang Min, Jennifer Martinez

ICHRIE Research Reports

Semiautonomous food delivery robots are expanding rapidly across college campuses, healthcare facilities, office complexes, and other food delivery settings. The semiautonomous food delivery robot market grew to about $800 million in 2025 and is expected to exceed $3.24 billion by 2030.

This report draws on research studies conducted at a university contract foodservice beta deployment site, involving in-depth interviews with employees and managers who worked directly with semiautonomous food delivery robots during and after implementation, triangulated with field notes and observations by the research team. The report highlights key findings and develops an original practitioner framework around these findings, called …

Building Consumer Trust In Short-Term Rentals: A Literature Review On Factors Influencing Consumer Booking Motivations And Trust Formation, Alyssa N. Thornton, Kiyan Shafieizadeh

ICHRIE Research Reports

This study synthesizes existing research on consumer trust formation and booking motivations in short-term rental (STR) platforms through a systematic literature review. Drawing on 19 peer-reviewed studies published between 2015 and 2025, the review examines how trust-building cues and motivational factors jointly influence consumer booking decisions in peer-to-peer accommodation contexts. Using a thematic analysis approach, the findings reveal five dominant themes: visual and aesthetic cues, host attributes, reviews and reputation mechanisms, economic and functional motivations, and host–guest interaction. The results highlight the central role of visual presentation and social signals in reducing perceived risk and fostering trust, while economic and …

Pricing Hawaii: When Discounts, Fees, And Transparency Collide In Hotel Pricing, Kody Dominguez, Ingrid Lin

ICHRIE Research Reports

This report examines how hotel pricing structures in Hawaiʻi; specifically, Kamaʻāina discounts, visitor rates, and destination fees interact to shape perceptions of fairness, transparency, and booking behavior.

Using survey data from 192 respondents and a pricing audit of 57 properties in Oahu, Hawaii, the findings reveal a structural disconnect between pricing intent and guest experience. While Kamaʻāina discounts range from 20–30%, mandatory destination fees averaging $37.69 significantly erode realized savings, particularly at mid-tier price points. As a result, 62% of residents perceive hotel pricing as unfair, compared to 27% of visitors, and nearly 70% of respondents report abandoning bookings due …

Beyond The Aisle: The Essential Guide For Event Planners To Navigate Cultural Diversity In Weddings, Ellee N. Marsh, Mary Olle Dr.

ICHRIE Research Reports

This research aims to address an educational gap within the event planning community regarding cultural diversity across the wedding industry. As the wedding market within the United States continues to increasingly globalize, planners are encountering couples from a wide variety of cultural, ethnic, and religious backgrounds. Understanding and appreciating a wide range of these cultures creates an important baseline of someone else’s background in order to recognize where people are coming from and why they want certain traditions present. Recognizing this lack of cultural knowledge within the wedding planning community, I have developed a cultural wedding handbook that is designed …

Guests Attitude And Purchase Intention Towards Hotel Brand Extension, Daegeun Kim, Eun-Kyong (Cindy) Choi, Tanya Ruetzler, James Taylor

ICHRIE Research Reports

Brand extension is widely used among firms and hotels to launch new products using their parent brand name, making it important for practitioners to understand which factors influence consumers' attitude toward brand extension (ATT). This study investigated the role of consumer brand identity (CBI) in guests' attitude leading to purchase intention (PUR) for hotel vacation rentals. Findings suggest that CBI was a positive antecedent of perceived fit (PF) and tie (PT), which positively influenced ATT. Additionally, parent brand conviction and quality were identified as factors that positively influenced ATT and led to PUR. As the first study on hotel vacation …

Positioning Grand Junction As A Premier Golf Tourism Hub: A Swot Analysis, Tevfik Demirciftci, Eunkyeong Jung

ICHRIE Research Reports

This research report examines how experienced golf travelers perceive Grand Junction (GJ) as a golf tourism destination. Based on in-depth interviews, the study uses a SWOT-based approach to identify strengths, weaknesses, opportunities, and risks from the golfer’s perspective. Findings show that GJ is valued for its affordability, natural scenery, variety of courses, and extended playing season, but its potential is hindered by limited coordination among tourism stakeholders. The results suggest that stronger collaboration among golf courses and local businesses could enhance GJ’s appeal as an accessible and distinctive destination for golf tourism

Accreditation In Hospitality And Tourism Administration/Management: A History, Robert H. Bosselman

ICHRIE Research Reports

Accreditation in hospitality and tourism administration/managment education has a complex history. The current manuscript provides background on how accreditation was established in the field. The role played by International CHRIE and its members was reported as was the origin of the Accreditation Commission for Programs in Hospitality Administration. The manuscript provides suggestions for future direction of accreditation in hospitality and tourism administration/management education.

Prevalence Of Cerebrovascular Disease In Patients With Coronary Artery Disease After Pharmacological Stress Test, Eman Mahmoud Abdelfattah, Muhammad Salem Muhammad Hagrass, Khalid Ahmed Elkhashab, Sameh Emil, Hassan Mohamed Ebeid, Lamya Salih, Najah Makhbout Al-Amri, Mostafa Sayed, Haytham Soliman Ghareeb

Journal of the Saudi Heart Association

Objectives: Coronary artery disease (CAD) and cerebrovascular disease (CVD) share common atherosclerotic pathways. However, the clinical significance of headache absence during stress testing remains unexplored. We investigated whether the absence of headache during pharmacological stress testing reflects the presence of subtle cerebrovascular atherosclerosis detectable by transcranial Doppler ultrasonography (TCD).

Methods: This cross-sectional study enrolled 225 patients with CAD undergoing pharmacological stress testing with TCD and myocardial perfusion imaging (MPI) at centers in Egypt (Cardiology Department, Fayoum University). Patients were stratified by headache status during stress testing. Multivariate logistic regression and receiver-operating characteristic (ROC) analysis identified independent predictors of abnormal TCD …

A Process For The Preparation Of Xanomeline And Its Pharmaceutically Acceptable Salts, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Shaik Mahammad Rafee And Buvanagiri Ajay Kumar.

Defensive Publications Series

The present disclosure relates to a process for the preparation of pure Xanomeline of formula-1 and its pharmaceutically acceptable salts. The structure of the formula-1 is shown below:

Formula-1.

Health-Gated Deploy-Authority Reconciler, Gustavo Matthew Assuncao

Defensive Publications Series

This document discloses a post-deploy reconciler that keeps a single, high-blast-radius production workload converged to an authorized image without reverting legitimate, healthy, out-of-band deployments. A short-interval reconciliation job reads a mutable, agent-writable in-cluster authority record — carrying an authorized image, a deploy-in-progress flag, a holder identity and a reason — and compares it against the live workload's running image and the readiness of its serving pod. The reconciler's corrective action is gated on a conjunction predicate: it reverts the workload to the authorized image only when the running image differs from the authorized image AND the serving pod is not …

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Dual-Plane Inbound Email Delivery, Gustavo Matthew Assuncao

Defensive Publications Series

This publication discloses, enablingly and in dated public form, a mechanism for inbound email delivery that simultaneously serves a human mail client and an autonomous software agent from a single ingress event, without duplicating the message, forking the pipeline, or degrading store fidelity. One webhook endpoint accepts two payload shapes — raw MIME posted as base64 by a byte-preserving edge worker, or already-parsed legacy JSON — and discriminates between them at runtime by the presence of a non-empty raw carrier field. Threading headers (Message-ID, In-Reply-To, References, Cc) are extracted continuation-aware directly off the raw bytes so that RFC 5322 folded …

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Provenance-Tiered Database Serve-Override Cms Over Immutable Container Assets, Gustavo Matthew Assuncao

Defensive Publications Series

This document discloses, as enabling public prior art, a content-management mechanism that layers a database-backed content overlay on top of an immutable set of static assets baked into a container image. A single GET-only "serve-override" resolver, keyed on the tuple (slug, locale, audience), returns a published database row when one exists and otherwise falls through to the baked file. The image is the read-only floor; the running pod is never written at request time. Two structural properties are central. First, a reserved-slug set — authentication, session, and OAuth callback paths — is never overridable, so security-critical routes always execute baked, …

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Deterministic Stateless Digital-Twin Rendering Of A Live Ai-Agent Workforce With Ledger-Windowed Replay, Gustavo Matthew Assuncao

Defensive Publications Series

This document discloses, with enabling detail sufficient for a person of ordinary skill to build it, a method and system for rendering a live, game-like visualization of a workforce of autonomous software agents in which every visual property is a pure deterministic function of operational records and the renderer holds no game state. Avatar state resolves by an active-work-wins-over-the-clock precedence; deterministic hashing places desks and picks palette swatches with a bounded collision-walk over the true floor grid; an ambient night tint is computed from the share of off-shift ("dreaming") agents plus the server hour, never a viewer's clock; ledger events …

Spec-Less Differential Api/Rbac Conformance Scanner With Source-As-Oracle Auth Probing, Llm Test Synthesis, And Automatic Bug-To-Repair Handoff, Gustavo Matthew Assuncao

Defensive Publications Series

This publication discloses a computer-implemented method and system that scans a running HTTP/REST service for authentication and role-based access-control (RBAC) conformance defects without any machine-readable API specification. Conventional API security scanners (Schemathesis, RESTler, 42Crunch, StackHawk, and comparable tools) require an OpenAPI/Swagger document or a recorded traffic corpus to know both what endpoints exist and what each endpoint's correct behavior is. The disclosed mechanism removes that dependency by treating the service's router source code as the single source of truth: a lightweight parser enumerates route registrations, and — the central novelty — the auth-middleware tokens present on each route's own physical …

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Modality-Blind, Local-First Handwriting Evidence Ingestion With Server-Side Image Rejection And Absence-Never-Denies Gate Equity, Gustavo Matthew Assuncao

Defensive Publications Series

Adaptive-learning platforms increasingly want to admit analog work — a photographed page of handwritten work — as assessment evidence alongside typed and spoken answers. The obvious implementation is corrosive: it uploads a child's handwriting image to a server, applies a single blanket consent posture across every capture surface, and — most insidiously — lets the presence of a shiny new evidence channel become an implicit penalty for the learner who has no camera, no printer, or no wish to photograph their work. This disclosure describes a mechanism that structurally refuses all three failure modes. First, the client performs deterministic on-device …