Digital Commons Network^™

Re: Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 26 – Cripple Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Statistical Analysis Of Multi-Endpoint Phenotypic Screening Increases Sensitivity Of Planarian Neurotoxicity Testing, Danielle Ireland, L. J. Word, Eva-Maria S. Collins

Biology Faculty Works

There is an urgent need for high-throughput screening (HTS) models to replace, refine, and/or reduce (“3Rs”) vertebrate toxicity testing. Replacing in vivo animal studies is challenging for neurotoxicity and developmental neurotoxicity (DNT), where the functional relevancy of adverse outcomes needs to be assessed on the whole organism. We previously screened the NTP 87-compound library (NTP87), consisting of known and suspected developmental neurotoxicants, and showed that planarian HTS can identify known (developmental) neurotoxicants. Because analysis methods can impact screening results, and our original analysis used the lowest-observed-effect-level (LOEL) only, we hypothesized that the use of state-of-the-art statistical analysis would increase the …

Dclk1 Isoform (Dclk1-S) As A Critical Player In Promoting Inflammation, Tissue Remodeling, And Emt In Mouse Models Of Colitis., Kafayat Yusuf, Badal C. Roy, William L. Hauser, Mazin Al-Kasspooles, Sierra Sanchez, Thomas M. Attard, Dong Pei, Venkatesh Sampath, Shrikant Anant, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIMS: The Doublecortin-like kinase-1 (DCLK1) plays a chemosensory role in the gut. It's role in the context of inflammatory diseases including inflammatory bowel disease (IBD), has not been thoroughly investigated. This study explored the role of the DCLK1 isoform (DCLK1-S) in promoting infectious/chemical colitis by utilizing high-throughput imaging mass cytometry (IMC).

METHODS: Transgenic mice were either infected with Citrobacter rodentium (CR) or received DSS and tissues/cells were processed via standard techniques. IMC workflow was adapted by Fluidigm (renamed Standard BioTools). Raw data was fed to Multiplexed Cell Dataset (MCD) Viewer for image generation and analyzed via histoCAT. Promoters …

Biogenic Synthesis And Characterization Of Metal Oxides Nanostructures Using Plant-Mediated Extracts Via Green Microwave-Assisted Method, Sahar Ismael Imran

Baghdad Science Journal

Two simple innovative green methods have been developed to synthesize precise phase of cobalt oxide nanostructures Co₃O₄; the first method included using cobalt hydroxide carbonate (extra pure) Co₂CO₃(OH)₂ with aqueous plants extract of syzygium aromaticum (clove) bud extract (SABE) once; then again with pomegranate peel extract (PPE) both samples were submitted to microwave irradiation for 5 minutes followed by discrete calcination at 500 ^oC and then 850 ^oC an interested shapes of doted semi-cubic of Co₃O₄-NPs was successfully obtained in both cases; the samples …

Dragon Guitars And Sexy Zombies: Tracing The Meta-Motion Of The Naga Motif In Northeast Thailand, Aaron Michael Stanley

Dartmouth College Master’s Theses

Abstract

This thesis traces the evolving symbolism of the Naga motif (a mythic water serpent) in Northeast Thailand through a framework I call meta-motion, which maps symbolic persistence of this cultural signifier and boundary marker across four cultural horizons—animist (Z), Hindu–Khmer (B), Buddhist (A), and modern/global (C). Like electrons in quantum super position, symbolic motifs circulate as overlapping “waves” of potential meaning and are concretized into cultural “particles” only when recruited for specific ritual, commercial, or political purposes. I add a bookend extension to Chang’s Hindu-Buddhist (B/A) typology with the addition of Horizons Z and C in order to make …

Association Of Glucagon-Like Peptide-1 Receptor Agonists With Cancer Risk In Older Adults With Type 2 Diabetes, Ying Lu, Hao Dai, Huilin Tang, William T Donahoo, Thomas J George, Ramon C Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D Licht, John M Allen, Kelvin P Lee, Jingchuan Guo, Jiang Bian

Faculty, Staff and Student Publications

Objective: The real-world evidence on the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and cancer risk remains limited and mixed.

Methods: In 2013-2020 national Medicare claims data, we included cancer-naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP-1 RA, sodium-glucose cotransporter 2 inhibitor (SGLT2i), or dipeptidyl peptidase 4 inhibitor (DPP4i) and conducted 1:1 propensity score matching for confounding adjustment. Cox proportional hazards models were used to estimate hazard ratios (HR) of nine obesity-associated cancers (thyroid, pancreatic, bladder, colorectal, lung, kidney, breast, endometrial, and prostate cancer).

Results: In the matched GLP-1RA versus SGLT2i cohort (n = 21,362 …

Implementation Of Patient-Centered Approaches To Enhance Engagement And Satisfaction In Psychiatric Care Within A Family Mental Health Service, Nnenna Attah

Walden Dissertations and Doctoral Studies

Summary I conducted this evaluation of a quality improvement initiative at a family mental health service center aimed to enhance patient engagement and satisfaction in psychiatric care through patient-centered approaches. The practice problem addressed in this project was the lack of patient engagement and satisfaction. This issue is critical to address within the context of nursing practice because patient-centered care is fundamental to improving clinical outcomes, patient satisfaction, and overall quality of care. The practice-focused question was: How can patient-centered approaches enhance patient engagement and satisfaction in psychiatric care? In the project, I focused on evaluating the impact of patient-centered …

Tort Liability For Failure To Age Gate: A Promising Regulatory Response To Digital Public Health Hazards, Matthew B. Lawrence, Brett Frischmann, Avi Sholkoff

Faculty Publications

Tort liability for failure to “age gate” is a promising legal response to the public health hazards of AI, social media, sports gambling, and other digital spaces. Tort liability for failure to “age gate” hinges liability for harms to minors on an app’s failure to take reasonable steps to prevent minors from gaining access or otherwise to apply appropriate governance rules, such as privacy-protective default settings or ensuring genuine parental consent. While no one legal response is a panacea, tort liability for failure to age gate carries several distinctive advantages that make it a particularly promising option at this stage …

2025-08-21 Faculty Senate Meeting Minutes (First Meeting Of The Adams Administration), Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from August 21, 2025. The first meeting of Dr. Adams' administration.

2025-08-21 Faculty Senate Meeting Minutes (Last Meeting Of The Lennex Administration), Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from August 21, 2025. The last meeting of Dr. Lennex's administration.

2025-08-21 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from August 21, 2025.

2025-08-21 Faculty Senate Scoop Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate Scoop newsletter from August 21, 2025.

Leveraging Sequences Missing From The Human Genome To Diagnose Cancer, Ilias Georgakopoulos-Soares, Christopher A Maher, Et Al.

2020-Current year OA Pubs

BACKGROUND: Cancer diagnosis using cell-free DNA (cfDNA) has the potential to improve treatment and survival but has several technical limitations.

METHODS: In this study, we developed a prediction model based on neomers, DNA sequences 13-17 nucleotides in length that are predominantly absent from the genomes of healthy individuals and are created by tumor-associated mutations.

RESULTS: We show that neomer-based classifiers can accurately detect cancer, including early stages, and distinguish subtypes and features. Analysis of 2577 cancer genomes from 21 cancer types shows that neomers can distinguish tumor types with higher accuracy than state-of-the-art methods. Generation and analysis of 465 cfDNA …

Triage Of Road Injury Casualties - The Role Of Bystanders: A Scoping Review, George Stephen Russam, Jake Gluyas-Harris, Nicholas Aveyard, Tim Nutbeam

Peninsula Medical School

Background: Bystanders have the potential to be a critical component of the Road Injury Chain of Survival, particularly in the early phases of injury recognition, scene assessment, and emergency service activation. Their potential role in trauma triage remains underexplored. This scoping review aims to examine the existing evidence of the use of bystanders in triage—both laypersons and non-clinical professionals—during the prehospital phase of road injury and other trauma scenarios. Methods: A systematic search was undertaken across MEDLINE, CINAHL, and the Psychology & Behavioural Sciences Collection using the EBSCO Host platform, with supplementary hand searches via Google Scholar and reference screening. …

Humanizing Cities As An Approach For Solving Cities' Problems To Be More Livable, Kareem Mahrous Ali

Mansoura Engineering Journal

Most people around the world want to move from the countryside to the cities or from one city to another that provides them with all their human needs for a better life. The dream may come true for them or turn into a nightmare for reasons related to general problems facing most cities in the world, such as the high cost of living and the absence of social justice, these problems cause an increase in poor families, or the issue of refugees and the inability of some cities to welcome them, the energy crisis, and the challenges of climate change …

Large-Scale Flood Detection And Mapping In The Yangtze River Basin (2016–2021) Using Convolutional Neural Networks With Sentinel-1 Sar Images, Xuan Wu, Zhijie Zhang, Wanchang Zhang, Bangsheng An, Zhenghao Li, Rui Li, Qunli Chen

Environment and Society Faculty Publications

Synthetic Aperture Radar (SAR) technology offers unparalleled advantages by delivering high-quality images under all-weather conditions, enabling effective flood monitoring. This capability provides massive remote sensing data for flood mapping, while recent rapid advances in deep learning (DL) offer methodologies for large-scale flood mapping. However, the full potential of deep learning in large-scale flood monitoring utilizing remote sensing data remains largely untapped, necessitating further exploration of both data and methodologies. This paper presents an innovative approach that harnesses convolutional neural networks (CNNs) with Sentinel-1 SAR images for large-scale inundation detection and dynamic flood monitoring in the Yangtze River Basin (YRB). An …

Full-Stack Quantum Computing, Benjamin C A Morrison

Physics & Astronomy ETDs

Quantum computing is a promising tool for solving computational problems in several areas, including the simulation of physical and chemical systems. The design of practical quantum computing systems for these applications is a daunting task, requiring collaborative work by interdisciplinary teams considering different abstractions of the same systems. This dissertation presents work on the development of those abstractions, and on components that bridge multiple layers of abstraction. I first provide an introduction to quantum circuit model computation, error correction with stabilizer codes, and physics simulation algorithms. In joint work with the QSCOUT software team, I then describe the development of …

Circzfr/Ythdf3 Axis Drives Lymph Node Metastasis In Cervical Cancer Via Fasn Translation, Mingyi Zhou, Yan Gao, Yong Zhang, Lian He, Bo Gao, Yue Zhang, Francois X Claret, George A Calin, Danbo Wang

Faculty, Staff and Student Publications

Background: Lymph node metastasis is a key driver of poor outcomes in cervical cancer. However, the molecular mechanisms of circular RNAs (circRNAs) driving cervical cancer lymph node metastasis remain unclear.

Methods: We identified circZFR, fatty acid synthase (FASN) and YTH N6-methyladenosine RNA binding protein F3 (YTHDF3) protein expression in the cervical cancer patients with long and short disease-free survival (DFS). Functional experiments were performed to investigate the function of circZFR, FASN and YTHDF3 on cell migration and invasion. MeRIP-qPCR, RNA pulldown, RNA Immunoprecipitation (RIP), and Co-Immunoprecipitation (Co-IP) assays were executed to investigate the mechanism of circZFR regulating FASN protein expression. …

Phase 1/2 Trial Of Encorafenib, Cetuximab, And Nivolumab In Microsatellite Stable Brafv600e Metastatic Colorectal Cancer, Van K Morris, Christine M Parseghian, Vahid Bahrambeigi, Nourhan Abdelfattah, Lianchun Xiao, Anjali Agrawal, Kangyu Lin, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Ryan W Huey, Bryan K Kee, Michael J Overman, Jason A Willis, Phat H Le, Michelle Escano, Yunyu C Baig, Kelsey Pan, David Menter, Alda L Tam, Wai C Foo, Li Shen, Hey Min Lee, Thomas D Gallup, Cori Margain, Dave Gallup, Kimal I Rajapakshe, Paola A Guerrero, Jing Wang, Ryan B Corcoran, Anirban Maitra, Kyuson Yun, Scott Kopetz

Faculty, Staff and Student Publications

The BRAF inhibitor encorafenib and anti-epidermal growth factor receptor (EGFR) antibody cetuximab modestly improve survival for patients with microsatellite stable (MSS) BRAFV600E metastatic colorectal cancer (mCRC), characterized by higher immune activation than MSS BRAFwild-type colorectal cancer (CRC). In this phase 1/2 study (NCT04017650) of 26 participants with MSS BRAFV600E mCRC who received encorafenib, cetuximab, and anti-PD-1 antibody nivolumab, we report an overall response rate of 50% (95% confidence interval [CI] 29-71) and median progression-free survival of 7.4 months (95% CI, 5.6-9.6). Transcriptomic profiling of pretreatment biopsies and extracellular vesicle RNA (evRNA) isolated from plasma show enrichment of non-canonical …

Human Interpretable Grammar Encodes Multicellular Systems Biology Models To Democratize Virtual Cell Laboratories, Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Ian C Mclean, Yoseph W Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, John Metzcar, Jacob T Mitchell, Andrew Raddatz, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, David G Denardo, Andrew J Ewald, Daniele M Gilkes, Luciane T Kagohara, Ashley L Kiemen, Elizabeth D Thompson, Denis Wirtz, Laura D Wood, Pei-Hsun Wu, Neeha Zaidi, Lei Zheng, Jacquelyn W Zimmerman, Jude M Phillip, Elizabeth M Jaffee, Joe W Gray, Lisa M Coussens, Young Hwan Chang, Laura M Heiser, Genevieve L Stein-O'Brien, Elana J Fertig, Paul Macklin

Faculty, Staff and Student Publications

Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual framework-a cell behavior hypothesis grammar-that uses natural language statements (cell rules) to create mathematical models. This enables systematic integration of biological knowledge and multi-omics data to generate in silico models, enabling virtual "thought experiments" that test and expand our understanding of multicellular systems and generate new testable hypotheses. This paper motivates and describes the grammar, offers a reference implementation, and demonstrates its use in developing both de novo mechanistic models and those informed …

Β-Catenin Functions As A Molecular Adapter For Disordered Cbaf Interactions, Yuen San Chan, Qinyu Gao, Sarah A Robinson, Wenzhi Wang, Ruzena Filandrova, Lisa-Maria Weinhold, Mario Loeza Cabrera, Miao Zhang, Chandra Shekar R Ambati, Antonio M Lerario, Nagireddy Putluri, Katja Kiseljak-Vassiliades, Margaret E Wierman, Mouhammed Amir Habra, Gary D Hammer, Vaclav Veverka, Katerina Cermakova, H Courtney Hodges

Faculty, Staff and Students Publications

BAF (SWI/SNF) chromatin remodelers engage binding partners to generate site-specific DNA accessibility. However, the basis for interaction between BAF and divergent binding partners has remained unclear. Here, we tested the hypothesis that scaffold proteins augment BAF's binding repertoire by examining β-catenin (CTNNB1) and steroidogenic factor 1 (SF-1, NR5A1), a transcription factor central to steroid production in human cells. BAF inhibition rapidly opposed SF-1/β-catenin enhancer occupancy, impairing SF-1 target activation and SF-1/β-catenin autoregulation. These effects arise due to β-catenin's role as a molecular adapter between SF-1 and an intrinsically disordered region (IDR) of the canonical BAF (cBAF) subunit ARID1A. In contrast …

Does Patient Age Influence Procedural Management Of Kidney Trauma?, Nizar Hakam, Behzad Abbasi, Umar Ghaffar, Kevin D Li, Hiren Patel, Charles P Jones, Joseph Cuschieri, Benjamin N Breyer

2020-Current year OA Pubs

OBJECTIVES: We aimed to examine the association between patient age and procedural intervention, especially nephrectomy, in patients with renal trauma in the National Trauma Data Bank (NTDB).

MATERIALS AND METHODS: We queried the 2013-2020 NTDB for adult renal trauma patients with an American Association for the Surgery of Trauma (AAST) grade. Patients without AAST grade or with no sign of life were excluded. We constructed a multinomial logistic regression model to demonstrate the association between age and procedural interventions (renal angioembolization, renorrhaphy and nephrectomy). Models were adjusted for patient, hospital, and clinical factors.

RESULTS: Our cohort was comprised of 49,884 …

Evaluating Snapshotnir For Tissue Oxygenation Measurement Across Skin Types After Mastectomy, Saif Badran, Sara Saffari, William R Moritz, Gary B Skolnick, Amanda M Westman, Mitchell A Pet, Justin M Sacks

2020-Current year OA Pubs

Accurate monitoring of mastectomy skin flap (MSF) perfusion is critical, especially in patients with darker skin pigmentation at higher risk of misdiagnosed tissue ischemia. Near-infrared spectroscopy (NIRS) devices, such as SnapshotNIR, offer real-time tissue oxygen saturation measurements (StO

Reducing Residential Landscape Water Use In Utah: Technologies And Strategies, Maya Cottam, Kendall Becker, Katlyn Stemmler, Shital Poudyal, Wesley Crump, Lewis Kogan, Scott Hotaling

All Current Publications

Water conservation is a critical issue in Utah, and several actions are already underway to help lower residential landscape water use. Strategies include smart irrigation controllers, efficient sprinkler bodies and nozzles, drip irrigation systems, soil amendments that increase water-holding capacity, and drought-tolerant grass cultivars for lawns. While additional conservation efforts will be necessary to reach sustainable water management, statewide adoption of current programs can help reduce water use and loss.

Investigation Of A Stable And Saturated Reference Electrode Using Metal Chlorides And Oxides In Eutectic Licl-Kcl Molten Salts, Carlos Mejia, Devin Rappleye

Faculty Publications

Stable and reproducible reference electrodes (REs) are essential for electrochemical systems operating in high-temperature molten salts, where consistent control of potential is required. This study uses three different solutes to investigate the development and evaluation of REs in eutectic LiCl-KCl at 773 K. The solutes tested were NiCl₂, AgCl, and NiO, each prepared at multiple concentrations to assess stability, reproducibility, and saturation. Electrochemical stability was measured over three days using chronopotentiometry (CP), followed by open circuit potential (OCP), with cyclic voltammetry (CV) also integrated to monitor changes in electrochemical behavior over time. The CP-OCP approach established a Li …

Re: Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp): Bres No. 91 – Robert Emmett Dumps, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Does Bubble Nucleation Occur Heterogeneously In Magmas Feeding Explosive Rhyolite Eruptions? Insights From The Rock Magnetic Properties Of Pumice, Kelly N. Mccartney, Julia E. Hammer, Thomas Shea, Stefanie Brachfeld, Thomas Giacheetti, Bruce F. Houghton

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Nanometer-scale titanomagnetite crystals have been detected in nominally aphyric rhyolite pumice, but whether they are numerous enough to impact bubble nucleation in explosive silicic volcanism was unresolved. This study examines sub-micron crystals using rock magnetic techniques, Rhyolite-MELTS modeling, and physical characterization. We analyzed pumice from four eruptions spanning wide ranges in intensity, storage depth, and bubble number density (1016 to 1013 m−3 liquid): 1060 CE Glass Mountain, 1912 CE Novarupta, 232 CE Taupo, and 0.45 Ma Pudahuel. Calculations assuming monospecific assemblages of 10 and 1,000 nm cubic particles yield titanomagnetite number densities of 1021 to 1013 m−3 dense rock equivalent, …

Music Manuscript From The Cdss Collection, Osgood, Bessie

Music and Dance

A music manuscript with the notation for the songs "Menuet de la Reine" and "Menuet Dauphin," both by François Marcel, on the front. "Menuet Dauphin" continues for one measure on the back. Sources are listed on the manuscript. Part of the collection of songs and dances from the 17th and 18th centuries gathered by Bessie Osgood; "Menuet de la Reine" is in D major and 6/4 time; "Menuet Dauphin" is in G major and 6/4 time.

Music Manuscript From The Cdss Collection, Osgood, Bessie

Music and Dance

A music manuscript folio with the notation for the songs "Mrs. Hamilton of Bangour's Minuet" and "The [Ladies] Farewell" on the front. The inner pages contain notation for the songs; "Handel's Quick March", "Tekeli", "Tink a Tink", "Turkish March", "[Federal] March", "The Recueille", "Handel's Clarinet", "Clementina", "Baltimore" and "White Cockade". The back page contains notation for the songs "Mrs. Nicolson's Minuet" and "The Muses Retreat" . Sources are listed on the manuscript. Part of the collection of songs and dances from the 17th and 18th centuries gathered by Bessie Osgood; "Mrs. Hamilton of Bangour's Minuet" is in E-flat major and …

Music Manuscript From The Cdss Collection, Osgood, Bessie

Music and Dance

A music manuscript with the notation for the songs "Minuetto" and "Youth the Season Made for Joys" on the front. The back page has notation for the songs "Air and Variations—Felton" and a "Minuetto" by Antonio Sacchini. Sources are listed on the manuscript. Part of the collection of songs and dances from the 17th and 18th centuries gathered by Bessie Osgood; Minuetto" is in B-flat major and 3/4 time; "Youth the Season made for Joys" is in C major and 4/4 time; "Air and Variations—Felton" is in C major and 3/4 time; "Minuetto" is in A major and 3/4 time.