Digital Commons Network^™

Death Penalty For Drug Offenders In Southeast Asia: Weakening Of Resistance To Change?, Wing Cheong Chan

Research Collection Yong Pung How School Of Law

Although the global movement towards abolition of the death penalty has been supported by an increasing number of countries in the world, the number of persons executed for drug offences actually increased in the last few years. Known executions for drug offences now account for more than 40 per cent of all global executions. Most such executions take place in Asia. Of the 34 countries in the world that still retain the death penalty for drug offenders, all nine of those identified as “high application states” (China, Indonesia, Iran, Kuwait, Malaysia, North Korea, Saudi Arabia, Singapore and Vietnam) are found …

Banking On Incumbents: How Do Fintech Start-Ups Benefit From Collaborations, Theodor Florian Cojoianu, Pia Helbing, Vladimir Pazitka, Dariusz Wojcik, Beiyun Xiao

Research Collection College of Integrative Studies

We investigate whether collaborations with established incumbents bolster innovation and access to capital for FinTech start-ups. Collaborations increase patent applications and raise both short-and long-term citations. Collaborations with finance incumbents stimulate finance and technology citations and boost both short-and long-horizon venture capital fundraising. These effects persist after addressing endogeneity and conducting additional robustness tests. Theoretically, our findings test the resource based theory in the FinTech ecosystem and enrich the open innovation literature by showing that, despite power asymmetries, FinTech start-ups can sustain innovative momentum and capture innovation gains via collaborations with incumbents. Collaborations function as credible signals that confer capital …

Bridging The Great Wall: China’S Evolving Cross-Border Data Flow Policies And Implications For Global Data Governance, Sheng Zhang, Henry S. Gao

Research Collection Yong Pung How School Of Law

Despite the rapid expansion of the digital economy, the global regulatory framework for data flows remains fragmented, with countries adopting divergent approaches shaped by their own regulatory priorities. As a key player in the Internet economy, China’s approach to cross-border data flows (CBDF) not only defines its domestic digital landscape but also influences emerging global norms. This paper takes a comprehensive view of the evolution of China’s CBDF regime, examining its development through both domestic and international lenses. Domestically, China’s regulation of CBDF has evolved from a security-first approach to one that seeks to balance security with economic development. This …

The Effect Of Tert Promoter Mutation On Predicting Meningioma Outcomes: A Multi-Institutional Cohort Analysis, Karenna J Groff, Ruchit V Patel, Yang Feng, Hia S Ghosh, Miguel A Millares Chavez, Joseph O'Brien, William C Chen, Vijay Nitturi, Akshay V Save, Mark W Youngblood, Craig M Horbinski, James P Chandler, Felix Ehret, Chloe Gui, Justin Z Wang, Kristen Park, Sonia Ajmera, Marc Rosenblum, Abigail K Suwala, Catena Kresbach, Christopher W Mount, Ulrich Schüller, Sandro Santagata, Felix Sahm, Tejus A Bale, Christina Jackson, Timothy E Richardson, Chunyu Cai, Farshad Nassiri, Gelareh Zadeh, David Kaul, David Capper, Stephen T Magill, John G Golfinos, Chandra Sen, Akash J Patel, David R Raleigh, Jennifer Moliterno, Donato Pacione, Matija Snuderl, Wenya Linda Bi

Duncan NRI Faculty and Staff Publications

Background: Molecular aberrations have been incorporated into tumour classification guidelines of meningioma. TERT-promoter (TERTp) mutation is associated with worse prognosis and is designated a WHO grade 3 biomarker. However, it remains unclear whether TERTp mutation is context-dependent, with other co-occurring genetic alterations potentially driving its association with prognosis. We sought to characterise the role of TERTp mutation in meningioma and guide TERTp sequencing.

Methods: We identified 1492 patients of all ages who had previously received surgery for meningioma across 14 medical centres in the USA, Canada, and Germany. Patients were eligible if they had post-surgical clinical or radiographical assessment of …

Plasma Lipidome Dysregulation In Frontotemporal Dementia Reveals Shared, Genotype-Specific, And Severity-Linked Alterations., Yohannes A Ambaw, Peter A Ljubenkov, Shubham Singh, Abdi Hamed, Sebastian Boland, Adam L Boxer, Tobias C Walther, Robert V Farese

Duncan NRI Faculty and Staff Publications

Introduction: Biomarkers are essential for monitoring the progression of frontotemporal dementia (FTD). Although dysregulated brain lipid metabolism, particularly sphingolipids enriched in the nervous system, is a key feature of neurodegeneration, plasma lipids remain underexplored as biomarkers compared to imaging and serum proteins.

Methods: We examined plasma lipidomes using liquid chromatography-tandem mass spectrometry (LC-MS/MS) from individuals carrying pathogenic variants linked to autosomal dominant FTD (GRN, C9orf72, MAPT) and non-carriers.

Results: FTD subjects exhibited increased plasma levels of gangliosides (GM3(d18:1_16:0), GM3(d18:1_24:1)), ceramide Cer(d18:1_23:0), and select polyunsaturated triacylglycerols. In contrast, phosphatidylethanolamine (PE(18:0_24:0) and sphingomyelin (SM(38:0) were reduced. Subtype-specific changes included elevated glucosylsphingosine (GlcSph(d18:1) …

Optimizing Initial Screening For Colorectal Cancer Detection With Adherence Behavior, Sarah Yini Gao, Yan He, Ruijie Zhang, Zhichao Zheng, Shao Wei Lam Lam, Emile Tan

Research Collection Lee Kong Chian School Of Business

Background: Two-stage screening programs are widely adopted for early colorectal cancer (CRC) detection, where individuals receiving positive outcomes in the first-stage (initial) test are recommended to undergo a second-stage test (colonoscopy) for further diagnosis. Methods: We study the initial test design—the selection of cutoffs for reporting test outcomes—to balance the trade-off between screening effectiveness (i.e., CRC and polyp detection) and efficiency (i.e., colonoscopy costs), incorporating the fact that not all individuals follow up with a colonoscopy after receiving positive outcomes. We integrate the Bayesian persuasion framework with information avoidance to model this problem and apply it to Singapore's CRC screening …

Temporal Patterns Of New Product Introductions And Ipo Value: The Importance Of Recency, Dispersion, And Asymmetry, Suyun Mah, Rebecca J. Slotegraaf, Girish Mallapragada

Research Collection Lee Kong Chian School Of Business

A firm’s innovation activity is often judged by the number and type of new products it launches, but when these products are introduced may be equally important, especially before going public. This research investigates how the temporal pattern of new product introductions (NPIs) influences a firm’s initial public offering (IPO) value. The analysis uses data from 298 firms that went public between 2006 and 2023, and focuses on three patterns of timing: recency (how recently the latest product was launched before the IPO), dispersion (the degree to which NPIs before the IPO are spread out over time), and asymmetry (how …

Why Stressed Candidates Make Better Cross-Cultural Hires, Shilpa Madan

Research Collection Lee Kong Chian School Of Business

When interviewing job candidates, you may look for evidence that they stay calm under pressure and interpret signs of stress as red flags. However, our recent research shows that for cross-cultural positions, those red flags might actually indicate your best potential hires. Candidates who exhibit signs of stress may be better suited to navigate the complexities of cross-cultural roles, suggesting a need to reassess traditional interview evaluations.

Optimal Abort Policy For Mission-Critical Systems Under Imperfect Condition Monitoring, Qiuzhuang Sun, Jiawen Hu, Zhi-Sheng Ye

Research Collection College of Integrative Studies

Although most on-demand mission-critical systems are engineered to be reliable to support critical tasks, occasional failures may still occur during missions. To increase system survivability, a common practice is to abort the mission before an imminent failure. We consider optimal mission abort for a system whose deterioration follows a general three-state (normal, defective, failed) semi-Markov chain. The failure is assumed self-revealed, whereas the healthy and defective states have to be inferred from imperfect condition-monitoring data. Because of the non-Markovian process dynamics, optimal mission abort for this partially observable system is an intractable stopping problem. For a tractable solution, we introduce …

Tetrigidae Of Ethiopia: First Species Delimitation Via Dna Barcoding And Description Of Three New Species †, Tarekegn Fite, Hendrik Devriese, Dustin Kulanek, Josip Skejo, Niko Kasalo, Manaye Misganaw, Tadele Tefera, Jandouwe Villinger, Martin Husemann

All Peer-Reviewed Publications

Tetrigidae is a caeliferan family of Orthoptera constituting a diverse and relatively ancient lineage of small Orthopterans, which has its greatest diversity in tropical and subtropical areas. However, to date, few studies have been conducted on the identification and description of Tetrigidae species in Ethiopia, and even fewer molecular data are available. Hence, we performed the first species delimitation study via DNA barcoding of species belonging to the genera Paratettix, Leptacrydium, Dasyleurotettix, and Morphopoides from Ethiopia. We provide 35 new sequences of the COI gene belonging to six species of these genera. We show that Ethiopian Tetrigidae can be successfully …

Volatile Pyrethroid Spatial Repellents For Preventing Mosquito Bites: A Systematic Review And Meta-Analysis, Ingrid Chen, Sarah L. Miller, Daniel Msellemu, Aidi G. Lugenge, Johnson Kyeba Swai, Nicole Achee, Marta Andrés, Christopher S. Bibbs, Theeraphap Chareonviriyaphap, J. Derek Charlwood, Greg Devine, Noel Elman, Ulrike Fillinger, Carmen Flores-Mendoza, Seth Gibson, Nicodem Govella, Steven Gowelo, Sebastian Horstmann, Hitoshi Kawada, Daniel Kline, Aaron Lloyd, Neil F. Lobo, Marta F. Maia, Arnold Mmbando, Mara Moreno-Gómez, Amy C. Morrison, Winifrida Mponzi, Emmanuel P. Mwanga, Margaret Njoroge

All Peer-Reviewed Publications

Background: Volatile pyrethroid spatial repellents (VPSRs) can prevent mosquito-borne diseases including malaria and dengue fever, but the use of varied evaluation methods has resulted in a lack of clarity regarding their protective efficacy (PE) against contact with mosquitoes. This systematic review and meta-analysis consolidates the entomological evidence base on the PE of VPSRs against Anopheles, Aedes, and Culex mosquitoes and different test methods used. Methods: We identified studies completed between January 2000 and September 2023 by searching through databases, conference abstracts, and personal correspondences. Included studies were semi-field or field studies that measured the PE of VPSRs using human landing …

Maize Yield Stability Under Organic And Conventional Farming Systems In Sub-Humid Agro-Ecozones Of Central Kenya, Milka Kiboi, David Bautze, Felix Matheri, Amritbir Riar, Andreas Fliessbach

All Peer-Reviewed Publications

Maize (Zea mays L.) is the main staple crop and is important to the food security and livelihoods of people globally. We evaluated the effects of organic and conventional farming systems on maize grain yield and temporal yield stability under different external input levels in a long-term experiment (2007–2022) at two sites in Kenya. We implemented four farming systems: organic high (Org-High), conventional high (Conv-High), organic low (Org-Low), and conventional low (Conv-Low) in a randomized complete block design. Growth indicators for maize, height, stem diameter, and grain yield were higher in high input systems, but grain yield stability was not. …

Spatial Distribution Of Microsporidia Mb Along Clinal Gradient And The Impact Of Its Infection On Pyrethroid Resistance In Anopheles Gambiae S.L. Mosquitoes From Nigeria And Niger Republic, Lamine M. Moustapha, Muhammad M. Mukhtar, Abdoul Nasser H. Sanda, Shuaibu Adamu, Yusuf Y. Aliyu, Hadizat K. Einoi, Maryam U. Maigari, Peter C. Okeke, David E. Nwele, Abiodun Obembe, Udoka C. Nwangwu, Jeremy K. Herren, Sulaiman S. Ibrahim

All Peer-Reviewed Publications

Microsporidia MB (MB), a promising biological control agent, suppresses Plasmodium falciparum transmission in Anopheles mosquitoes. This study examined the spatial distribution of MB infection in natural populations of An. gambiae s.l. mosquitoes collected in Nigeria and Niger Republic, and its association with insecticide susceptibility in the mosquitoes. Microsporidia MB has wide geographic distribution across Nigeria and Niger Republic. The overall prevalence of MB in F0 mosquitoes was 12.25% (95% CI: 7.76–16.75%); 25 mosquitoes out of 204 were positive. Geographic variation was observed, with a higher prevalence (5/15 mosquitoes) in Ebonyi State (33.33%, CI: 9.48–57.19%, Fisher’s exact test, p = 0.008). …

Assessing The Impact Of Tungiasis On Children's Quality Of Life In Kenya, Lynne Elson, Berrick Otieno, Abneel K. Matharu, Naomi Riithi, Esther Jebor Chongwo, Francis Mutebi, Hermann Feldmeier, Jürgen Krücken, Ulrike Fillinger, Amina Abubakar

All Peer-Reviewed Publications

Tungiasis is a neglected tropical skin disease caused by the sand flea, Tunga penetrans which penetrates the skin causing considerable pain and itching. In this cross-sectional study we aimed to assess its impact on the quality of life of school children in Kenya. School pupils (198) aged 8-14 years with tungiasis were randomly selected and interviewed using a tungiasis-specific quality of life instrument (TLQI). The caregivers of each infected pupil and 199 randomly selected caregivers of uninfected pupils were interviewed using the proxy KIDscreen52 to assess their child's general health-related quality of life (HR-QoL). Generalized linear models were used to …

2025 Resident Scholar Reflection: Teresa Saxton, Teresa Saxton

Marian Fellowships and Other Sponsored Research in the Marian Library

When using archives in the classroom, students are asked to engage with an object from another time and place and confront the humanity of those that made and used it. The pedagogical gift of archives is that they inspire curiosity to know more but also ask us to grapple with what we cannot know.

Predicting Clinical Success Of Ct-Based Functional Drained Liver Volume Assessment In Malignant Biliary Obstruction, Ethan Y Lin, Bruno C Odisio, Koustav Pal, Iwan Paolucci, Ryan P Kempen, Nicolas Cardenas, Paige Reed, Ketan Y Shah, Ahmed Awad, Rahul A Sheth, David Fuentes, Alda Tam

Faculty, Staff and Student Publications

Purpose

To compare the predictive accuracy of subjective versus objective assessment of three-dimensional functional drained liver volume (fDLV) for clinical success after percutaneous transhepatic biliary drainage (PTBD).

Materials and Methods

This retrospective study included patients with malignant biliary obstruction and hyperbilirubinemia who underwent de novo PTBD between January 2016 and February 2017. Clinical success was defined as achieving total bilirubin level less than 1.8 mg/dL (30.8 μmol/L) within 30 days after PTBD. Seven interventional radiologists independently categorized subjective fDLV into four groups: less than 30%, 30%–50%, 51%–75%, and greater than 75% of the total liver volume. Objective fDLV was calculated …

Designing An Electronic Patient-Reported Outcomes Information Infrastructure Supported By The Re-Aim Implementation Framework, Amy C Moreno, Angela Peek, Toshiko S Stein, Kevin R Shook, Sara M Ali, Laia Humbert-Vidan, Aileen Chen, Miriam Lango, Anna Lee, Michael Spiotto, William H Morrison, Adam S Garden, Jack Phan, Steven J Frank, Katherine Hutcheson, David I Rosenthal, Clifton D Fuller, G Brandon Gunn

Faculty, Staff and Student Publications

Objective: Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life and survival. However, the implementation of electronic PROs (ePROs) remains a challenge from technical and evaluation perspectives. Our objective was to construct a robust electronic health record (EHR)-integrated ePRO information infrastructure founded on RE-AIM (reach-effectiveness-adoption-implementation-maintenance) principles.

Materials and methods: We used Epic Systems as our EHR platform to build the MD Anderson Symptom Index Head and Neck Module (MDASI-HN) for release to all patients undergoing evaluation and/or treatment in our HN Radiation Oncology clinics. RE-AIM metrics were established …

Using Extension-Based Mrna Display To Design Antibody-Like Proteinogenic Peptides For Human Pd-L1, Justin N Ong, Brian J Grindel, Scott A Rankin, Sarah H Naylon, Anupallavi Srinivasamani, Guillaume J Trusz, Xiaowen Liang, Md Nasir Uddin, Lauren Fuller, Michael Curran, Stephane P Roche, Terry T Takahashi, Richard W Roberts, Steven W Millward

Faculty, Staff and Student Publications

Many peptide drugs rely on nonproteinogenic amino acids and chemical modifications for improved activity and proteolytic stability. However, these features also make drug production expensive and challenging to scale. Here, we engineered small, linear, proteinogenic peptides that bind human programmed death-ligand 1 (hPD-L1) with high affinity and stability using mRNA display affinity maturation. The resulting peptides, SPAM2 and SPAM3, have antibody-like affinities for hPD-L1 (dissociation constants between ~250 and 300 pM) and are selective for hPD-L1. Both SPAM2 and SPAM3 compete with hPD-L1 ligands known to interact with the programmed cell death protein 1 site and are stable in human …

Mechanisms Underlying Treatment-Resistant Depression: Exploring Sex-Based Biological Differences, Francisco E R Da Silva, Atakan Yucel, Antonio P M Menezes, Ana C Ruiz, Marcela C Carbajal Tamez, Tatiana Barichello, Giselli Scaini, Joao Quevedo

Faculty, Staff and Student Publications

Treatment-resistant depression (TRD) represents a severe and complex subtype of major depressive disorder (MDD), affecting approximately 30% of patients who fail to respond adequately to multiple standard antidepressant therapies. While the pathophysiology of TRD remains incompletely understood, emerging evidence suggests that sex-based biological differences might influence its onset, progression, and treatment response. Women are disproportionately affected by depression and are more likely to experience residual symptoms and treatment resistance, potentially due to hormonal fluctuations, immune system differences, and variations in brain circuitry and neuroplasticity. This narrative explores the current literature on the mechanisms underlying TRD, with a particular emphasis on …

Risk Of Second Primary Lung Cancer Among Cancer Survivors Stratified By The Site Of First Primary Cancer And The Lung Cancer Screening Eligibility Status, Sara Nofal, Edwin J Ostrin, Jianjun Zhang, Jia Wu, Paul Scheet, Mara B Antonoff, John V Heymach, Iakovos Toumazis

Faculty, Staff and Student Publications

Personal history of cancer is an independent risk factor for developing lung cancer. However, it is not considered in the current US lung cancer screening (LCS) guidelines. In this study, we assessed the risk of developing lung cancer among cancer survivors across 24 different sites of first primary cancer stratified by their LCS eligibility status. Using data from the Patient History Database at the University of Texas MD Anderson Cancer Center, we calculated and compared the cumulative incidence of second primary lung cancer, the overall and the LCS eligibility status-specific, stratified by the site of first primary cancer among cancer …

Preference-Based Deep Reinforcement Learning For Historical Route Estimation, Boshen Pan, Yaoxin Wu, Zhiguang Cao, Yaqing Hou, Guangyu Zou, Qiang Zhang

Research Collection School Of Computing and Information Systems

Recent Deep Reinforcement Learning (DRL) techniques have advanced solutions to Vehicle Routing Problems (VRPs). However, many of these methods focus exclusively on optimizing distance-oriented objectives (i.e., minimizing route length), often overlooking the implicit drivers' preferences for routes. These preferences, which are crucial in practice, are challenging to model using traditional DRL approaches. To address this gap, we propose a preference-based DRL method characterized by its reward design and optimization objective, which is specialized to learn historical route preferences. Our experiments demonstrate that the method aligns generated solutions more closely with human preferences. Moreover, it exhibits strong generalization performance across a …

Behavioral Bias And Manager Success In Major League Baseball, Daniel Pastor, Jason R. Reed, Arjun Sondhi

Department of Agricultural Economics Faculty Publications

Using results from 26 Major League Baseball seasons, we investigate the connection between behavior bias, managerial success, and tenure. We ask whether managers that have overachieved, relative to prior seasons, have a greater chance of remaining in that role, and if so, what was the subsequent effect on team performance. Our results indicate that MLB owners and team general managers are susceptible to behavioral biases. Team managers that overachieve in a season, relative to recent, historical team performance, endure longer tenures with their team, however, overachieving managers have statistically similar career win percentages to managers who underachieved. This result suggests …

Understanding Glufosinate Resistance In Palmer Amaranth And Examination Of Additives For Improved Weed Control, Pamela Carvalho-Moore

Graduate Theses and Dissertations

The aim of this dissertation was to: 1) provide an in-depth review about the potential use of natural and synthetic glutathione S-transferase (GST) inhibitors to enhance herbicidal activity or induce crop safety; 2) determine if the addition of metabolic inhibitors to glufosinate is an effective approach to enhance weed control; 3) investigate the mechanism conferring resistance to glufosinate in a highly-resistant Palmer amaranth accession; 4) characterize the genomic rearrangement involved in glutamine synthetase 2 amplification in a Palmer amaranth accession resistant to both glufosinate and glyphosate; 5) quantify the distribution of glufosinate resistance among Palmer amaranth accessions within a 15-km …

A Mobility Data-Driven Approach To Analyzing And Modeling Park Accessibility Inequities And Use In U.S. Cities, Michaelmary Chukwu

Graduate Theses and Dissertations

Urban Park accessibility inequities have been a longstanding issue globally and the United States in particular. Despite the benefits that urban parks provide, use and access is not equitably distributed among the population, often favoring historically privileged populations over others (disadvantaged). Fortunately, improvements have been made in recent years to promote balanced park distribution in some cities; however, evidence still shows that most cities are behind. Interestingly, the rise in human mobility data has facilitated the study of human behavior and use of activity spaces. This thesis advances the existing studies on park accessibility and emerging human mobility to study …

Media’S New-Age Opinion Leaders: Audience Perceptions Of Smi Credibility And Opinion Leadership Role, Alyssa Claire Riley

Graduate Theses and Dissertations

With worldwide technological and communication advancements in the last few decades, everyday citizens can capture, create, and share news through social media platforms. Nowadays, prominent social media influencers (SMIs) influence where and from whom online audiences consume their news and information. This study aims to explore how different SMI attributes – such as attractiveness, expertise, and trustworthiness – and their social media tactics create or add to audience perceptions of SMIs as credible online opinion leaders. Applying Two-Step Flow theory and Source Credibility theory, the study used data from a survey of 115 participants to understand how audiences perceived the …

Exploring The Relationship Between Grit, Burnout, And Academic Success Among First-Year Osteopathic Medical Students During Fundamentals Of Anatomic Science I Course, Heather Guzik

Graduate Theses and Dissertations

Burnout is a significant issue among healthcare professionals. Burnout refers to the mental, emotional, and physical exhaustion that can develop throughout one’s career or studies. It can affect professionalism and patient care (National Academies of Sciences, Engineering, and Medicine: National Academy of Medicine, 2019). Studies have shown that burnout begins early in an individual's medical education and can increase throughout their training (Voltmer et al., 2021). It has been suggested that students with a high level of Grit may exhibit some resistance to burnout (Jumat et al., 2020; Lee et al., 2022). This noncognitive trait measures a person’s ability to …

Sound Decisions: The Impact Of Music Genre In Fashion Advertising On Consumer Perceptions And Purchase Intention, Cassandra Thomas

Graduate Theses and Dissertations

This study examines how music genre, brand type, and the perceived congruency between the two influences consumer perceptions of fashion advertising. Guided by Congruity Theory and Attitude Theory, this study employed a 3x3 experimental design in which 252 participants viewed one of nine advertisement conditions varying by music genre (pop, hip-hop, electronic) and brand type (activewear, fast fashion, luxury). A series of one-way ANOVAs, bivariate correlations, and regression analyses were conducted to interpret the effects of music genre, brand type, and perceived congruency on attitudes toward 1) the advertisement and brand, 2) credibility of the advertisement and brand, and 3) …

Unbound Bilirubin And Risk Of Severe Neurodevelopmental Impairment In Extremely Low Birthweight Newborns, Cody C Arnold, Ivana Maric, Ronald J Wong, Jon E Tyson, David K Stevenson

Faculty, Staff and Student Publications

Background: Unbound bilirubin (UB) was measured on day 5 ± 1 in 1101 ELBW newborns in the Aggressive vs Conservative Phototherapy randomized controlled trial. We accessed this dataset to quantify the UB-mediated risk of severe neurodevelopmental impairment (sNDI) in extremely low birthweight (ELBW) newborns.

Methods: UB levels were standardized within laboratories as z-score percentiles. A dichotomous UB exposure variable was based on sharply increased risk of sNDI at the 85th percentile (UBz>85th). Targeted maximum likelihood estimation with ensemble machine learning (TMLE + ML) and logistic regression (LR) were used to estimate sNDI risk attributable to UBz>85th.

Results: UB …

Utility Of Whole-Slide Imaging For Rapid Evaluation Of Thyroid Fna: A Multireader Prospective Study, Mohammed S Ahmed, Dianna Klippel-Almaraz, Sara E Amin, Gloria H Sura, Uma Rani Kundu, Wendong Yu, Jogn M Stewart, Qiong Gan, Savitri Krishnamurthy

Faculty, Staff and Student Publications

Background: Rapid on-site evaluation (ROSE) of thyroid fine-needle aspiration biopsy (FNAB) improves diagnostic adequacy and facilitates ancillary molecular testing. In this prospective, multireader study, the authors evaluated the feasibility of using whole-slide images (WSIs) for ROSE to determine specimen adequacy and preliminary categorization (according to The Bethesda System for Reporting Thyroid Cytopathology [Bethesda]) of image-guided thyroid FNABs compared with conventional light-microscopic (LM) examination of the same specimens in a referral cancer center.

Methods: The authors evaluated 98 ultrasound-guided thyroid FNAB cases. Smears were stained with Papanicolaou and Diff-Quik and were scanned at ×20 magnification using a Leica Aperio CS2 scanner. …

Examining The Impact Of Area Deprivation On Endovascular Stroke Therapy Access, Joseph N Samaha, Ngoc Mai Le, Emmanuel C Ebirim, Rania Abdelkhaleq, Sergio A Salazar Marioni, Muhammad Bilal Tariq, Ananya Iyyangar, Anjan Nagesh, Hussain Azeem, Arash Niktabe, Sunil A Sheth

Faculty, Staff and Student Publications

Background: Equitable access to health care is heavily affected by socioeconomic factors. However, the effects of such disparities in accessing life-saving treatments remain incompletely characterized. Here we explore the impact of disparities on access to endovascular treatments for large vessel occlusion acute ischemic stroke.

Methods: From our prospectively maintained multihospital registry, we identified patients with large vessel occlusion acute ischemic stroke from January 2019-June 2020. Patient addresses and zip codes were matched to census-tract level area deprivation index (ADI) scores that were obtained from Neighborhood Atlas. ADI is a validated neighborhood-level measure that uses variables such as income, education, and …