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Moralists Or Moral Hypocrites? Leveraging Moral Psychology And Social Identity Theory To Increase Support For Reparations Amongst White Americans, Andre Oliver Sep 2025

Moralists Or Moral Hypocrites? Leveraging Moral Psychology And Social Identity Theory To Increase Support For Reparations Amongst White Americans, Andre Oliver

Dissertations, Theses, and Capstone Projects

The economic gains America made from the enslavement of Africans have long been considered its original sin; indeed, most people living today would agree that such an enterprise was morally depraved. Yet, due to moral opposition, many White Americans reject reparative policies (i.e., reparations) that are developed to remedy the damages done to African Americans by slavery and the subsequent continued discrimination. The present research attempts to address two broad hypotheses across four empirical research studies. The first hypothesis tests whether White Americans' rejection of reparative policies related to slavery and Black discrimination is inherently a moral objection to taboo …


Receptions Of Mental Health Emergency Services In New York City, Daniel R. Samost Sep 2025

Receptions Of Mental Health Emergency Services In New York City, Daniel R. Samost

Dissertations, Theses, and Capstone Projects

Mental health emergency response has become a highly scrutinized topic following the Black Lives Matter movement and several notable incidents of mental health emergency service users being killed by police responders. Qualitative interviews were conducted with mental health emergency service users to better understand the experience of using mental health emergency services, garner critical feedback of the service, and explore recommendations to improve future response. A total of 23 participants conducted interviews and detailed 40 incidents of mental health emergency service utilization. These interviews were then coded and analyzed. There were a few major findings from the data. Just over …


Potential Role Of A Ruthenium-Based Compound Ru-Im In The Treatment Of Triple Negative Breast Cancer, Rachele Rameau Sep 2025

Potential Role Of A Ruthenium-Based Compound Ru-Im In The Treatment Of Triple Negative Breast Cancer, Rachele Rameau

Dissertations, Theses, and Capstone Projects

Triple negative breast cancer (TNBC) is an aggressive and heterogeneous molecular subtype of breast cancer that has limited available treatments. The organometallic cationic ruthenium derivative Ru-IM was found to be highly water soluble, was differentially toxic for breast cancer cells and tumors, and was involved in the pI3K/AKT/mTOR pathway. However, a full understanding of genetic and epigenetic factors that can be part of regulatory mechanisms of Ru-IM is yet to be determined. Epigenetic assays including DNA methylation, histone acetylation and histone deacetylation were performed with the half inhibitory concentration (IC50) values of Ru-IM. Bisulfite sequencing of untreated and treated MDA-MB-231 …


Interoceptive Forecasting And Recall: The Role Of Anxiety Sensitivity And Disgust Sensitivity, David Lloyd Yap Sep 2025

Interoceptive Forecasting And Recall: The Role Of Anxiety Sensitivity And Disgust Sensitivity, David Lloyd Yap

Dissertations, Theses, and Capstone Projects

Predicting and remembering emotional states (affective forecasting and recall) are adaptive processes that allow individuals to engage with the future and past to guide behavior, yet these processes are prone to bias. Although affective forecasting and recall biases are common across healthy populations, more pessimistically biased affective forecasts and recall have been linked to greater anxiety and depression symptom levels and to emotional disorders. A crucially understudied aspect of affective forecasting and recall is the perception of the somatic (interoceptive) symptoms that accompany emotions. This study investigated forecasting and recall accuracy of somatic symptom levels (i.e., interoceptive forecasting and recall). …


Collaborative Memory And Metamemory: The Impact Of Normative And Informational Motivations On Conformity, Karen Rodriguez Sep 2025

Collaborative Memory And Metamemory: The Impact Of Normative And Informational Motivations On Conformity, Karen Rodriguez

Dissertations, Theses, and Capstone Projects

Collaborative memory studies have typically explored the cognitive mechanisms that underlie differences between collaborative and individual memory performance. Despite the social nature of collaboration, few studies have examined the impact of social motivations on collaborative memory. When retrieving information with groups, people may not only be motivated by a desire to be accurate (i.e., informational motivations), but may also be guided by social norms (i.e., normative motivations), such as prioritizing agreeability or alignment with group members (Cialdini & Goldstein, 2004). Similarly, retrieving information with others may also prompt individuals to reflect more on their own memory processes. However, few studies …


Enjoyment In The Classroom: Reciprocal Student-Teacher Dynamics In Israeli Math Education, Yonaton Gutterman Sep 2025

Enjoyment In The Classroom: Reciprocal Student-Teacher Dynamics In Israeli Math Education, Yonaton Gutterman

Dissertations, Theses, and Capstone Projects

Enjoyment is increasingly recognised as a keystone emotion in contemporary models of academic motivation and learning (Pekrun, 2006; Ryan & Deci, 2020). Grounded in Control-Value, Expectancy-Value, and Self-Determination theories, the present study tracked reciprocal affective processes in Israeli mathematics classrooms across ten lessons. Seven teachers and their 257 students (112 fourth-graders; 145 eighth-graders) completed parallel post-lesson questionnaires assessing feedback use, enjoyment, and perceived difficulty. Multilevel ordinal mixed-effects models, latent-growth curve models, and Bayesian random-intercept cross-lagged panel models were estimated to disentangle within-person fluctuations from between-person differences (Hamaker et al., 2015). Confirmatory-factor analyses supported scalar invariance of the key scales over …


The Weight Of Complicity: A Network Analysis Of Ecocide In Palestine, Marilyn Moy Sep 2025

The Weight Of Complicity: A Network Analysis Of Ecocide In Palestine, Marilyn Moy

Dissertations, Theses, and Capstone Projects

This paper combines multi-criteria decision analysis (MCDA) with a network graph visualization to examine corporate and institutional involvement in ecocide in Palestine from 1917 to the present. Using a weighted sum model based on UN human rights principles and UNEP guidelines, actors are evaluated across three criteria: directness, scale, and duration of harm. A dataset of 50+ entities, including Caterpillar, Elbit Systems, and the Jewish National Fund, reveals a dense network of responsibility, with major enablers in the construction, tech, and military sectors. Findings highlight the severe impacts of the 2023–present assault on Gaza and demonstrate that ecocide is a …


Imagined Empires: Roman And Chinese Constructions Of One Another In Antiquity, Elizabeth S. Tsang Sep 2025

Imagined Empires: Roman And Chinese Constructions Of One Another In Antiquity, Elizabeth S. Tsang

Dissertations, Theses, and Capstone Projects

This thesis examines how the Roman and Han Chinese empires conceptualized one another during the first centuries CE, despite never establishing sustained direct contact. It argues that mutual perceptions were shaped less by firsthand experience than by mediated reports, commodities, and the political interests of intermediaries. The study proceeds in four parts. The first explores how Roman authors employed the ethnonym Seres to frame China as a land of wonder, wealth, and alterity. The second analyzes the Chinese designation Da Qin, showing how it projected Han imperial ideals outward by casting Rome as a mirror-image polity. The third turns to …


Reduce, Replace, Reframe: How Civil Society Organizations Build Resilience In The Face Of Financial And Political Pressures, Merrill Sovner Sep 2025

Reduce, Replace, Reframe: How Civil Society Organizations Build Resilience In The Face Of Financial And Political Pressures, Merrill Sovner

Dissertations, Theses, and Capstone Projects

In order for civil society organizations (CSOs) to perform essential functions to support democracy and prevent democratic erosion, they must operate sustainably, maintaining resources and legitimacy to carry out their missions. CSOs experience financial and political pressures when resources and legitimacy are withdrawn. CSOs facing both pressures may reduce their activities, replace lost funding, or reframe their work to engage new audiences. How CSOs respond in the face of financial and political pressures has implications for their role in hindering democratic erosion. Yet civil society organizations weather these pressures in ways that are not straightforward; the most targeted organizations may …


Dónde Están: Searching For Desaparecidos Of The Argentine Dirty War, Paula Fleischer Sep 2025

Dónde Están: Searching For Desaparecidos Of The Argentine Dirty War, Paula Fleischer

Dissertations, Theses, and Capstone Projects

This project is a data physicalization textile representing the 30,000 'desaparecidos' from the Argentine Dirty War of late 1970s. The large quilt visualizes the official count of 9,000 missing persons in the shape of a headscarf worn by their mothers and grandmothers, while the overall dimensions of the quilt acknowledges 30,000 missing persons. The quilt and accompanying missing persons posters encourage the viewer to interact with the data, however the observed reluctance to engage influenced the direction of this discussion about the hegemonic disinclination to get involved when authority figures 'disappear' fellow residents of our communities.


Low-Resource Ecoacoustic Audio Classification, Enis Berk Coban Sep 2025

Low-Resource Ecoacoustic Audio Classification, Enis Berk Coban

Dissertations, Theses, and Capstone Projects

Ecoacoustic monitoring via machine learning enables scalable analysis but is often constrained by labeled data scarcity, particularly in remote regions like the Arctic. This thesis confronts low-resource ecoacoustic audio classification by developing and evaluating complementary machine learning methodologies. We introduce EDANSA, the first publicly available, expert- labeled Arctic dataset of its kind, curated via novel active learning, alongside a baseline CNN. We systematically evaluate transfer learning, showing general audio embeddings effectively bootstrap classifiers for challenging Arctic sounds, significantly outperforming direct label mapping. Optimizing label utility, we investigate standard data augmentation and introduce novel audio data valuation via Shapley values, revealing …


Giving Voice To The Frames Of War: A Digital Humanities Framework For Evaluating War Crimes Databases, Leila Markosian Sep 2025

Giving Voice To The Frames Of War: A Digital Humanities Framework For Evaluating War Crimes Databases, Leila Markosian

Dissertations, Theses, and Capstone Projects

Developments in digital technologies have complicated existing debates around the ethics of cataloging war crimes and human rights violations. Digital humanities methods of evaluating digital scholarship can help to construct a framework for evaluating war crimes databases, a process which requires a fine-tuned critical analysis aimed towards understanding the purpose of compiling the database, the platform or media template through which the database is presented, and the communicative potentials of the database. The following paper presents a survey of the existing literature on war crime databases and the politics of memory; a model of how war crimes database analyses may …


Scripted For Surveillance: Parole Revocation Hearings And The Performance Of Procedure In New York, Kelsey G. Greeff Sep 2025

Scripted For Surveillance: Parole Revocation Hearings And The Performance Of Procedure In New York, Kelsey G. Greeff

Dissertations, Theses, and Capstone Projects

This thesis examines parole revocation hearings in New York as complex performances that extend carceral control beyond prison walls. Drawing on a composite vignette from the Bronx parole court, it analyzes the interplay between procedural reform, constitutional due process, and neoliberal governance. Using a dramaturgical framework informed by Michel Foucault’s discourse analysis and Judith Butler’s theory of performativity, the study identifies four interrelated processes: the judge as director, who orchestrates hearings according to institutional priorities; normalization, where repetition embeds structural inequality as routine; type-marking, the classification of parolees into predefined roles through accumulated records and cues; and the extension of …


Medication Adherence Among Partnered, Sexual Minority Men Living With Hiv: What’S Love, Interdependence And Comorbidities Got To Do With It?, Kendell M. Doyle Sep 2025

Medication Adherence Among Partnered, Sexual Minority Men Living With Hiv: What’S Love, Interdependence And Comorbidities Got To Do With It?, Kendell M. Doyle

Dissertations, Theses, and Capstone Projects

Sexual minority men (SMM) report higher incidence and prevalence rates of HIV infection relative to their heterosexual counterparts. The burden of HIV infection has garnered research attention focused on HIV risk reduction and HIV disease management (such as medication adherence). More recently, attention has been paid to the association of comorbid chronic health conditions and ART adherence among people living with HIV (PLWH) more broadly. Yet, limited attention has been paid to the association of comorbidities among SMM living with HIV specifically, despite the high rates of HIV among this population and various other risk factors that put SMM at …


The Density Distribution Of The Material Around Betelgeuse, Iman Behbehani Sep 2025

The Density Distribution Of The Material Around Betelgeuse, Iman Behbehani

Dissertations, Theses, and Capstone Projects

Betelgeuse is a red supergiant star visible in the constellation Orion. Its windy and highly convective surface results in a complicated mass loss pattern difficult to understand and replicate in simulations. The ejected mass can form a shell around the star we consider the circumstellar material (CSM). In this study, we use ALMA interferometric observations to find the structure of Betelgeuse's CSM, and connect to the mass loss mechanisms that could form it. We measure a bipolar circumstellar structure with a position angle of 42.3$\pm 7.0^\circ$. We observe asymmetries in the form of hot spots in the north east of …


Ai-Powered Multi-Omics Integration For Predictive Modeling Of Genotype-Environment-Phenotype Relationships, You Wu Sep 2025

Ai-Powered Multi-Omics Integration For Predictive Modeling Of Genotype-Environment-Phenotype Relationships, You Wu

Dissertations, Theses, and Capstone Projects

This dissertation presents a series of machine learning frameworks for modeling genotype–environment–phenotype relationships through integrative predictive modeling of multi-omics data. The work addresses three major axes of biological complexity: modeling biological information transmission cross-levels from genes to proteins to phenotypes, predicting molecular features cross-scale from cells to tissues to organisms, and translating phenotypes cross-species from model systems to humans. Each proposed method also tackles key machine learning (ML) challenges in the biomedical domain, including data scarcity, domain shift, out-of-distribution (OOD) generalization, and hierarchical modeling. Specifically, this dissertation introduces five novel deep learning algorithms: MultiDCP predicts drug-induced transcriptomic and viability responses …


Novel Machine Learning Methods For Quasar Variability And Strong Gravitational Lensing, Joshua Fagin Sep 2025

Novel Machine Learning Methods For Quasar Variability And Strong Gravitational Lensing, Joshua Fagin

Dissertations, Theses, and Capstone Projects

Machine learning methods are well suited to handle the unprecedented data volume expected from upcoming wide-field surveys. The European Space Agency's Euclid telescope was launched in July 2023 and is expected to observe billions of galaxies at high resolution, including tens of thousands of strongly lensed galaxies. The Rubin Observatory Legacy Survey of Space and Time (LSST) will monitor tens of millions of quasars throughout its ten-year lifetime, thousands of which will be strongly lensed. This flood of data will enable measuring lens galaxy mass distributions and substructure, as well as probing quasar accretion disk structure and black hole properties …


In A Dark Wood Amid The Storm: Literary Representations Of Midlife In The Social And Political Turbulence Of A Kindred Era, Robert Mccreanor Sep 2025

In A Dark Wood Amid The Storm: Literary Representations Of Midlife In The Social And Political Turbulence Of A Kindred Era, Robert Mccreanor

Dissertations, Theses, and Capstone Projects

The apparent parallels between the social and political crises of the 19-teens’s to 1930’s and those of today is a source of popular fascination and commentary. Some have argued that much of our current anxieties about impending global doom harken back to the widespread doomsaying of exactly a century ago in relation to World War I, the 1918 Spanish Influenza and the rising authoritarianism of the 1930’s. Exploration of the midlife experience amid 21st century political and social crises has been prolific and can also be seen to echo literary representations of this particular life stage from the seemingly …


Transitional Justice And Counter-Productivity: A Case Study Of Serbia And Croatia, Michael F. Curry Sep 2025

Transitional Justice And Counter-Productivity: A Case Study Of Serbia And Croatia, Michael F. Curry

Dissertations, Theses, and Capstone Projects

In the post-Cold War era, transitional justice emerged as a method to reconcile societies that had suffered large-scale human rights abuses through autocratic oppression and/or intra-state conflicts. During this time, the concept of what transitional justice meant and what problems it could resolve expanded exponentially. However, the empirical results of such initiatives have been mixed. Many states subject to transitional justice initiatives have failed to liberalize or develop domestic governance capacities. Why do transitional justice initiatives fail even under the most favorable conditions?

The most common answer to this question is that these initiatives are often ineffective, hindered by a …


Speaking From The Underground: Notes On Lois Elaine Griffith & The Nuyorican Poets Cafe Aesthetic, Joseph Anthony Cáceres Sep 2025

Speaking From The Underground: Notes On Lois Elaine Griffith & The Nuyorican Poets Cafe Aesthetic, Joseph Anthony Cáceres

Dissertations, Theses, and Capstone Projects

Speaking from the Underground explores the work of Lois Elaine Griffith, an Afro-Caribbean diasporic visual and literary artist of Barbadian descent and one of the last surviving founders of the Nuyorican Poets Cafe, a Puerto Rican cultural institution grounded in Afro-Caribbean traditions located in Manhattan’s Lower East Side. In the common, cultural parlance, the Cafe has become synonymous with spoken word and slam poetry. Since 1973 it has been the place where artists of mostly African, Caribbean, Latinx descent gather to craft works centered around lived experiences to shape a language to counter a conventional understanding of history and a …


Exploring The Role Of Ecological Traits In Shaping Spatial Patterns Of Genetic Diversity, Rilquer Mascarenhas Da Silva Sep 2025

Exploring The Role Of Ecological Traits In Shaping Spatial Patterns Of Genetic Diversity, Rilquer Mascarenhas Da Silva

Dissertations, Theses, and Capstone Projects

The field of comparative phylogeography aims at uncovering common underlying causes for shared patterns of diversity and diversification at the population level. However, it is now widely accepted that intraspecific genetic diversity patterns can differ considerably across co-occurring taxa due to ecological processes acting at the population level (and influencing individual movement and abundance). To model the processes underlying lineage diversification and demographic shifts in response to environmental changes, phylogeographers and population geneticists are now faced with the challenge of incorporating measurements of species ecological traits into their molecular studies. This dissertation aimed at investigating how different types of ecological …


“Justice, Justice Pursue”: Coworker Reactions To Religious Workplace Accommodations, Joshua A. Nagel Sep 2025

“Justice, Justice Pursue”: Coworker Reactions To Religious Workplace Accommodations, Joshua A. Nagel

Dissertations, Theses, and Capstone Projects

This study examines coworker reactions to religious accommodations in the workplace, a growing necessity as religious diversity increases, and recent legislation strengthens protections for religious observances. Religious accommodations can provoke perceptions of differential treatment, impacting coworker morale, cooperation, and organizational cohesion. While extensive research exists on disability accommodations, religious accommodations differ fundamentally as they often relate to moral beliefs and are viewed variably in terms of necessity and controllability. Drawing on organizational justice theories, this dissertation applies and modifies Colella’s (2001) and Colella et al.’s (2004) models for coworker perceptions of distributive and procedural fairness of disability accommodations to the …


Characterization Of The Attentional Profile In Women And Girls With A Fragile X Premutation Allele, Shira Russell-Giller Sep 2025

Characterization Of The Attentional Profile In Women And Girls With A Fragile X Premutation Allele, Shira Russell-Giller

Dissertations, Theses, and Capstone Projects

The fragile X premutation (PM), characterized by 55 to 200 CGG repeats in the FMR1 gene, is associated with diverse clinical outcomes, including cognitive and neuropsychiatric changes. Despite most individuals with a PM presenting without overt clinical symptoms, adults face increased risks for conditions associated with a PM, including higher rates of attention and executive difficulties. This dissertation investigates the developmental trajectory of attention and executive functioning changes in females with a PM using a series of prospective studies employing the Attention Network Test (ANT). Study 1 re-analyzed prior data on sustained attention in women with a PM, revealing significant …


The Spaces Between: A Phenomenological Exploration Of Classical Music Performance Practice, Fifi Zhang Sep 2025

The Spaces Between: A Phenomenological Exploration Of Classical Music Performance Practice, Fifi Zhang

Dissertations, Theses, and Capstone Projects

In his theory of duration, the philosopher Henri Bergson (1859-1941) asserts that the present moment is “both a perception of the immediate past and a determination of the immediate future…a joint system of sensations and movements.” In an ideal musical performance, this sensori-motor apparatus guides every one of the performer’s decisions on stage, resulting in an aural experience that is spontaneous, visceral, and deeply personal. In practice, much of today’s classical music performance culture, which relies heavily on visual notation and prioritizes fidelity to the composer’s intent, is antithetical to fundamental artistic values such as creativity, individual self-expression, and direct …


Retinal Precursor Cell Enriched Multiomic And Pseudo-Time Analysis Of Developing And Reprogrammed Photoreceptors, Brendon M. Patierno Sep 2025

Retinal Precursor Cell Enriched Multiomic And Pseudo-Time Analysis Of Developing And Reprogrammed Photoreceptors, Brendon M. Patierno

Dissertations, Theses, and Capstone Projects

The vertebrate retina is a complex tissue made up of seven major cell subtypes which during development must differentiate and localize into a highly organized structure. These neuronal cells do not regenerate if damaged or diseased, and the progressive deterioration of cone photoreceptor cells is the leading cause of age related blindness. Currently there are no cures for this disease, but one promising therapeutic avenue is cell transplantation research. If we can further elucidate the gene regulatory networks that define cone cell development, this knowledge could be applied to the generation of healthy cone cells in clinically relevant models.

The …


An Interpolating Regime For The Extreme Values Of A Random Zeta Model, Christine K. Chang Sep 2025

An Interpolating Regime For The Extreme Values Of A Random Zeta Model, Christine K. Chang

Dissertations, Theses, and Capstone Projects

We study the large values of a random model of the Riemann zeta function over short intervals. The extreme value statistics depend on the interval size: the log-correlated regime governs intervals of order one while the i.i.d. regime emerges over longer intervals. The main focus is to describe the transition between these two well-understood regimes as the interval varies in length. This thesis shows that there is an intermediate regime where the behavior of the zeta model’s maxima cannot be entirely captured by either extreme— i.i.d. or fully log-correlated. This suggests that the Riemann zeta function exhibits correlations around its …


Alerted And Anxious? The Effects Of Mobile Crime Alerts On Perceptions Of Personal And Public Safety, Amanda C. Benjamin Sep 2025

Alerted And Anxious? The Effects Of Mobile Crime Alerts On Perceptions Of Personal And Public Safety, Amanda C. Benjamin

Dissertations, Theses, and Capstone Projects

Mobile crime alert platforms promise to enhance personal and public safety by delivering frequent notifications about nearby dangers—claims that, until now, have not been experimentally tested. For-profit applications like Citizen deliver real-time, geo-targeted push notifications about nearby crime incidents to over 9 million users, often operating outside the bounds of institutional oversight. Although marketed as tools to enhance awareness and protection, these platforms may simultaneously empower users through information while also potentially amplifying anxiety, heightening threat perceptions, and eroding trust in community. Despite their increasing prominence and integration into public safety communications, the psychological and behavioral impacts of mobile crime …


Nonlinear Diffusion, Hydrodynamic Cascades And Jamming In Kinetically Constrained Systems: Insights From Lattice Gas Models, Abhishek Raj Sep 2025

Nonlinear Diffusion, Hydrodynamic Cascades And Jamming In Kinetically Constrained Systems: Insights From Lattice Gas Models, Abhishek Raj

Dissertations, Theses, and Capstone Projects

This dissertation investigates non-linear diffusion processes and emergent dynamical phenomena in kinetically constrained lattice gases. Two central models are considered: a one-dimensional lattice gas exhibiting a diffusion cascade triggered by hydrodynamic nonlinearities and a triangular ladder exclusion model that undergoes a jamming transition. The former demonstrates stretched exponential decay consistent with non-perturbative long-time tails, while the latter illustrates how classical-quantum mappings yield insight into glassy dynamics and mobility constraints. Through a combination of numerical simulations, analytical perturbation theory, and mean-field approximations, the work uncovers mechanisms underlying anomalous transport, jamming transitions, and the breakdown of perturbative hydrodynamics.


The Question Of Money: State, Protest, And Informal Currencies In The Wake Of Greece’S Economic Crisis, Helen Panagiotopoulos Sep 2025

The Question Of Money: State, Protest, And Informal Currencies In The Wake Of Greece’S Economic Crisis, Helen Panagiotopoulos

Dissertations, Theses, and Capstone Projects

Monetary unions are designed to foster political, social, and economic integration among member states by enabling the free movement of people, goods, services, and capital. Yet when a member nation faces economic crisis, citizens may respond by creating monetary systems of their own. This research asks whether such practices are simply demonstrations of human resiliency and adaptability, or whether they also challenge the very idea of a shared market and currency that do not align with national identity. Greece offers a crucial case for this inquiry. Following the 2008 debt crisis, austerity measures led to economic depression, mass unemployment, and …


The Sonic Hedgehog Effector Smoothened Modulates Cholinergic Interneuron Activity, Physiology, And Striatum-Dependent Behaviors, Santiago Uribe-Cano Sep 2025

The Sonic Hedgehog Effector Smoothened Modulates Cholinergic Interneuron Activity, Physiology, And Striatum-Dependent Behaviors, Santiago Uribe-Cano

Dissertations, Theses, and Capstone Projects

The striatum is a central node in action selection and associative learning, integrating cortical, thalamic, and neuromodulatory input. Among its principal modulators, dopamine (DA) and acetylcholine (ACh) are known for their temporally coordinated yet mechanistically distinct influences on striatal output. However, the upstream signals that regulate their dynamic interplay, particularly within cholinergic interneurons (CINs)—the primary source of striatal ACh—remain incompletely characterized. This dissertation investigates the role of Smoothened (Smo), a G protein-coupled receptor (GPCR) effector of Sonic Hedgehog (Shh) signaling, in modulating ACh signaling dynamics in the striatum.

Building on evidence that midbrain DA neurons co-release Shh and that CINs …