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Direct Numerical Simulation Of Unstably Stratified Turbulent Flow Over Riblets, Max Eltzroth Sep 2025

Direct Numerical Simulation Of Unstably Stratified Turbulent Flow Over Riblets, Max Eltzroth

Dissertations and Theses

Riblets are micro-groove elements which can reduce the skin friction drag coefficient for wall-, channel-, and pipe-flows. It is unclear how robust these drag-reduction capabilities are when external forces are acting on the fluid and affecting turbulent structures. Here, buoyancy forces are introduced by varying the wall Richardson number (Riτ = 0, 18, 60) to create unstable stratification. Direct numerical simulations (DNS) are performed on streamwise-aligned riblets of triangular and bladed geometries in a horizontal half-channel pressure-driven turbulent flow (Reτ = 395). The Fukagata-Iwamoto-Kasagi (FIK) identity is used to decompose how changes in stresses contribute to changes …


Generative Techniques In "The Third Man," For Fretless Electric Guitar And Electronics, Adam James Wilson Sep 2025

Generative Techniques In "The Third Man," For Fretless Electric Guitar And Electronics, Adam James Wilson

Publications and Research

“The Third Man” is the latest in a series of pieces, spanning fifteen years of iteration, for solo fretless guitar and “automatic improvisation” software. Prior works in the series have been performed throughout the United States, many of them at the New York City Electroacoustic Improvisation Summit between 2016 and 2024. The author serves as the principal performer/composer and programmer of this and prior works, which has enabled the progressive refinement of generative techniques to support very personal compositional aesthetics and performance practices. Setting aside the stylistic idiosyncrasies they serve, details of the relatively simple generative techniques used in “The …


The Politicization Of Security Issues In Political Leadership: A Study On The “Asing Dan Aseng” Narrative In Indonesian Elections, Suharjimantoro Suharjimantoro, Ratu Zahirah Lutfie Sep 2025

The Politicization Of Security Issues In Political Leadership: A Study On The “Asing Dan Aseng” Narrative In Indonesian Elections, Suharjimantoro Suharjimantoro, Ratu Zahirah Lutfie

Jurnal Wacana Politik

This study investigates the politicization of security issues in Indonesian electoral politics through the construction and mobilization of the “Asing dan Aseng” narrative—a rhetorical strategy that depicts foreign influence and ethnic Chinese communities as existential threats to national sovereignty. The research aims to understand how political actors strategically use this narrative to mobilize voter support and legitimize their leadership. Using the theoretical lens of securitization and the politics of fear, the study applies a qualitative method based on critical discourse analysis of purposively selected campaign speeches, media coverage, and propaganda materials from the 2014 and 2019 presidential elections and the …


E-Government Utilization And The Political Logic Of Network Governance In Indonesia’S Local Administration, Dewi Anggraini, Faturachman Alputra Sudirman, Nur Atnan, Muhammad Najib Husain Sep 2025

E-Government Utilization And The Political Logic Of Network Governance In Indonesia’S Local Administration, Dewi Anggraini, Faturachman Alputra Sudirman, Nur Atnan, Muhammad Najib Husain

Jurnal Wacana Politik

This article investigates the utilization of E-Government applications within the framework of network governance in Indonesia’s local administration. Drawing on both qualitative and quantitative methods, this study captures public perceptions of electronic information-based government services and explores the political and institutional dynamics underlying their implementation. Data were collected through questionnaires, document analysis, interviews, and focus group discussions (FGDs) with purposively selected informants, including leaders and staff from local government institutions. The findings demonstrate that e-government platforms enhance service efficiency, transparency, and public satisfaction. Moreover, these applications promote openness in financial management and intra-organizational communication, contributing to greater trust and comfort …


Mental Health Services For Older Hispanics/Latinos: Incorporating Culture And Context Into Clinical Approaches To Care, Denise Longoria, Romeo Escobar, John M. Gonzalez, Luis R. Torres-Hostos Sep 2025

Mental Health Services For Older Hispanics/Latinos: Incorporating Culture And Context Into Clinical Approaches To Care, Denise Longoria, Romeo Escobar, John M. Gonzalez, Luis R. Torres-Hostos

School of Social Work Faculty Publications

This article discusses older Latinos and their use of mental health services. A brief history of utilization and the contributing factors, including access to services, barriers, and acceptability of mental health services, are included. Sekhon et al.’s theoretical framework of acceptability is discussed in the context of Latino clients. The authors adapt the framework and apply the elements to work with older Latinos and their families. Common stereotypes and faulty assumptions about older Latinos are examined as the Latino population grows and changes in levels of education, language, family structure, roles, religion, and alternative practices continue. Core values for working …


Health Systems Responsiveness In Low And Middle-Income Countries (L&Mics): Revisiting Its Scope, Meesha Iqbal, Robert Morgan, Cici Bauer, Cecilia Ganduglia Cazaban, Sameen Siddiqi Sep 2025

Health Systems Responsiveness In Low And Middle-Income Countries (L&Mics): Revisiting Its Scope, Meesha Iqbal, Robert Morgan, Cici Bauer, Cecilia Ganduglia Cazaban, Sameen Siddiqi

Faculty, Staff and Student Publications

Introduction: Health systems responsiveness (HSR) addresses the legitimate non-health expectations of the population and plays a vital role in strengthening health systems and enhancing population health. Identifying specific constructs or domains within HSR is particularly important in the context of low and middle-income countries (L&MICs) to facilitate targeted improvement. Following a comprehensive systematic review of the literature, we developed a conceptual framework for HSR. This study was designed to validate our proposed framework through a Delphi process.

Methods: Global HSR experts were contacted via email to participate in the study, and a copy of the proposed framework (12 domains, 53 …


Details Matter: Getting People Involved, Cheryl A. Burkhart-Kriesel Sep 2025

Details Matter: Getting People Involved, Cheryl A. Burkhart-Kriesel

Cornhusker Economics

Sometimes getting people into the habit of community participation can be a bit challenging, but two aspects can help make this a little easier. The first is to make sure that there are no organizational barriers in participating, and the second is to realize that community participation happens on several levels and that each level has certain expectations. When these expectations are clearly stated, people are more easily motivated to get involved and stay involved.

Setting up engagement from the beginning requires thought and attention to detail. It can be insignificant things, like choosing a date or picking a location, …


Longitudinal Associations Of Epigenetic Aging With Cognitive Aging In Hispanic/Latino Adults From The Hispanic Community Health Study/Study Of Latinos, Myriam Fornage, Wassim Tarraf, Rui Xia, Adriana Ordonez, Tamar Sofer, Freddie Márquez, Bharat Thyagarajan, Gregory A Talavera, Linda C Gallo, Charles Decarli, Hector M González Sep 2025

Longitudinal Associations Of Epigenetic Aging With Cognitive Aging In Hispanic/Latino Adults From The Hispanic Community Health Study/Study Of Latinos, Myriam Fornage, Wassim Tarraf, Rui Xia, Adriana Ordonez, Tamar Sofer, Freddie Márquez, Bharat Thyagarajan, Gregory A Talavera, Linda C Gallo, Charles Decarli, Hector M González

The Brown Foundation: Institute of Molecular Medicine

Due to the paucity of longitudinal DNA methylation data (DNAm), especially among Hispanic/Latino adults, the association between changes in epigenetic clocks over time and cognitive aging phenotypes has not been investigated. This longitudinal study included 2671 Hispanic/Latino adults (57 years; 66% women) with blood DNAm data and neurocognitive function assessed at two visits ~7 years apart. We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit …


The "Secret Of Seven Stones": Short-Term Efficacy Of An Online Intergenerational Sexual Health Education Game For Early Adolescents And Their Parents, Ross Shegog, Christine Markham, Melissa Peskin, Robert C Addy, Sara Dube, Diane Santa Maria, Susan Tortolero Emery, Johnny M Wilkerson, Elizabeth Baumler, Laura Armistead, Pooja Chaudhary, Hsing-Yi Song, Angela Spencer, Jeffery Mclaughlin Sep 2025

The "Secret Of Seven Stones": Short-Term Efficacy Of An Online Intergenerational Sexual Health Education Game For Early Adolescents And Their Parents, Ross Shegog, Christine Markham, Melissa Peskin, Robert C Addy, Sara Dube, Diane Santa Maria, Susan Tortolero Emery, Johnny M Wilkerson, Elizabeth Baumler, Laura Armistead, Pooja Chaudhary, Hsing-Yi Song, Angela Spencer, Jeffery Mclaughlin

Faculty, Staff and Student Publications

Objectives: Intergenerational games offer a potential channel to impact parent-youth sexual health communication. The "Secret of Seven Stones" (SSS) is an 18-level online adventure game and parent website designed to engage parents and youth (11-14 years) in conversations about healthy dating relationships and sexual behavior and to provide sexual health skills training to youth. Study hypotheses were that SSS exposure would increase sexual health parent-child communication, increase youth intentions to delay sexual debut, and reduce youth exposure to situations that promote sexual activity.

Materials and Methods: SSS was evaluated in the homes of parent-youth dyads randomly assigned to intervention ( …


Neurobehavioral Symptom Profiles For The Behavioral Assessment Screening Tool In Chronic Traumatic Brain Injury, Shannon B Juengst, Brittany Wright, Annalyn Demello, Leia Vos, Fedora Biney, Luis Leon Novelo, Michael Williams Sep 2025

Neurobehavioral Symptom Profiles For The Behavioral Assessment Screening Tool In Chronic Traumatic Brain Injury, Shannon B Juengst, Brittany Wright, Annalyn Demello, Leia Vos, Fedora Biney, Luis Leon Novelo, Michael Williams

Faculty, Staff and Student Publications

Objective: To identify neurobehavioral symptom profiles among persons with chronic traumatic brain injury (TBI) using the Behavioral Assessment Screening Tool (BAST) and to consider participant characteristics that differ between profile groups.

Setting: Community.

Participants: Participants (n = 615) were English-speaking adults (≥18) and had a self-reported history of at least one TBI of any severity.

Design: Secondary analysis of cross-sectional data.

Main measures: The BAST measures neurobehavioral symptoms in the domains of Negative Affect, Fatigue, Executive Dysfunction, Impulsivity, and Substance Misuse.

Results: Using latent profile analysis (LPA), we identified 3 different neurobehavioral profiles. Overall symptom frequency and differences in the …


Bearing Witness: Témoignage As A Tool For Child Advocacy During Armed Conflict., Anik Patel, Amber Alayyan, Heather A. Haq, Parminder S. Suchdev, Naji Hattar, Jeffrey Goldhagen, David J. Schonfeld, Tanya Haj-Hassan, Lia Harris, Seema Jilani, Ayesha Kadir, Paul H. Wise, Lisa Umphrey Sep 2025

Bearing Witness: Témoignage As A Tool For Child Advocacy During Armed Conflict., Anik Patel, Amber Alayyan, Heather A. Haq, Parminder S. Suchdev, Naji Hattar, Jeffrey Goldhagen, David J. Schonfeld, Tanya Haj-Hassan, Lia Harris, Seema Jilani, Ayesha Kadir, Paul H. Wise, Lisa Umphrey

Manuscripts, Articles, Book Chapters and Other Papers

Children affected by armed conflict suffer devastating physical, emotional, and social harm. War uproots families, forcing many to flee as refugees or internally displaced persons, while others remain trapped in dangerous environments. In these crises, children face disproportionate risks-violence, exploitation, disrupted education, and collapsed healthcare systems. Their unique vulnerabilities require urgent, targeted action to protect their health, rights, and development. Beyond immediate care, the humanitarian principle of témoignage-bearing witness-is essential. Rooted in humanitarian ethics, témoignage means speaking out about injustice, amplifying the voices of those affected, and driving systemic change. It challenges traditional notions of neutrality and calls on humanitarian …


“Ni Hao” At The Southern Border: Crafting The U.S. Policy Response To The Post-Pandemic Cohort Of Chinese Migrants, Wei Luo Sep 2025

“Ni Hao” At The Southern Border: Crafting The U.S. Policy Response To The Post-Pandemic Cohort Of Chinese Migrants, Wei Luo

The Scholar: St. Mary's Law Review on Race and Social Justice

Undocumented migrants feature prominently in modern American politics. One group of migrants, however, has drawn relatively little attention—those from the People’s Republic of China. Leading up to the 2024 election, Chinese migrants were the fastest growing group of migrants entering from the U.S.-Mexico border. This Article proposes that U.S. policymakers take a three-prong approach to responding to Chinese migrants who have entered the country in recent years or who may enter in the future. First, use asylum law as an instrument of U.S. foreign policy and grant asylum to Chinese migrants in numbers appropriate to advance America’s national interest in …


The Unamerican Dream: Breaking The Barriers Of Standardized Testing For Ell Students In A Post-Affirmative Action Era, Laura Rua Sep 2025

The Unamerican Dream: Breaking The Barriers Of Standardized Testing For Ell Students In A Post-Affirmative Action Era, Laura Rua

The Scholar: St. Mary's Law Review on Race and Social Justice

This comment examines the impact of standardized testing on English Language Learners (ELL) in K–12 education. It explores the complexities and challenges these students face, including language barriers and cultural differences, which can significantly influence their test performance and educational outcomes. By analyzing existing research and legal frameworks, this comment assesses shortcomings of bilingual education in Texas and its under-preparation for ELL students to take standardized testing and whether current testing practices adequately accommodate the needs of ELL students.Ultimately, this comment proposes policy recommendations aimed at promoting fair and equitable assessment practices in bilingual education for K–12 ELL students.


Peremptory Norms And The Right To Self-Determination: The Case Of Puerto Rico, Carlos Chevere-Lugo, Sigrid Vendrell-Polanco Sep 2025

Peremptory Norms And The Right To Self-Determination: The Case Of Puerto Rico, Carlos Chevere-Lugo, Sigrid Vendrell-Polanco

The Scholar: St. Mary's Law Review on Race and Social Justice

No abstract provided.


Your Turn Texas: A Failed Bill For Conviction Integrity Units And Funding, Jasmine Silva Sep 2025

Your Turn Texas: A Failed Bill For Conviction Integrity Units And Funding, Jasmine Silva

The Scholar: St. Mary's Law Review on Race and Social Justice

This comment reviews the history and consequences of wrongful convictions, explores the proposed Conviction Integrity Act of 2021, and scrutinizes Texas's role in exonerations. The root of wrongful convictions depends on various factors. However, the slow overturn of wrongful convictions largely depends on the lack of funding conviction integrity units and innocence organizations receive. The devastating truth is that there are many known wrongfully incarcerated persons sitting in prison because of the amount of funds necessary to reinvestigate a possible exoneration. This comment walks through the Conviction Integrity Act of 2021, a bill proposed by Senator Klobuchar and Senator Cornyn, …


Developing Workflows For Passive Acoustic Detection Of Bedload Transport, Quinn Morgan Sep 2025

Developing Workflows For Passive Acoustic Detection Of Bedload Transport, Quinn Morgan

Dissertations and Theses

Bedload transport is defined as the amount of sediment, including gravel and rocks, traveling down stream. Monitoring bedload transport is important for river safety, hydrological studies and conservation efforts. Existing methods of directly measuring bedload transport (or bedload flux) involve lowering a collection device into a river and measuring the sediment collected; which can be expensive and time consuming. Hydroacoustic sensors, such as hydrophones, have had success tracking bedload flux remotely. This works by measuring the relatively high frequency of sediment impacts to map onto total bedload transported. No perfected method for detection of sediment generated noise (SGN) currently exists. …


Dental Educators’ Stress And Wellbeing In The Workplace- An International Perspective, Shannu Bhatia, Ruby Long, Sviatlana Anishchuk, Daniel Farnell, Morag Powell, Michael Bhotelo Sep 2025

Dental Educators’ Stress And Wellbeing In The Workplace- An International Perspective, Shannu Bhatia, Ruby Long, Sviatlana Anishchuk, Daniel Farnell, Morag Powell, Michael Bhotelo

Peninsula Dental School

Introduction: Supporting wellbeing of staff involved in dental education is vital to ensure the safe effective delivery of the curriculum and training of the dental workforce. There are only a limited number of studies on the stress and wellbeing of staff involved in dental education and the barriers they face in engaging with any wellbeing services provided. To plan strategies for the promotion of staff wellbeing, it is important to identify these and the barriers faced by staff. The aim of this study is to determine the stress and wellbeing of the staff involved in dental education and identify any …


Barriers Beyond Bars: Examining Experiences Of Students With Criminal Records, Anakin Rivera Ramirez Sep 2025

Barriers Beyond Bars: Examining Experiences Of Students With Criminal Records, Anakin Rivera Ramirez

Dissertations and Theses

As educational opportunities, particularly prison education programs, continue to expand for incarcerated individuals, this study, which included two participants, one formerly incarcerated and one who pleaded guilty to avoid incarceration, suggests that those who plead guilty to avoid prison may enter college without the structured reintegration resources available to their incarcerated peers. While substantial research has explored the school-to-prison pipeline phenomenon in K-12 settings, fewer studies have examined its impact on students with criminal records navigating higher education. Grounded in Critical Race Theory (CRT) in education, this study seeks to understand the experiences of carceral system-impacted students of color in …


Spartan Daily, September 10, 2025, San Jose State University, School Of Journalism And Mass Communications Sep 2025

Spartan Daily, September 10, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 8


Motion For Order Modifying 5th Amended Plan Sep 2025

Motion For Order Modifying 5th Amended Plan

Catholic Dioceses in Bankruptcy

No abstract provided.


Uc Minutes 2025-09-10, Northern Illinois University Sep 2025

Uc Minutes 2025-09-10, Northern Illinois University

University Council Archives

No abstract provided.


The George-Anne Daily, Georgia Southern University Sep 2025

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.


High Beta Power In The Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study, Nicole R Provenza, Sameer V Rajesh, Gabriel Reyes, Kalman A Katlowitz, Lokesha S Pugalenthi, Raphael A Bechtold, Nabeel Diab, Sandesh Reddy, Anthony K Allam, Ajay D Gandhi, Katherine E Kabotyanski, Kasra A Mansourian, Jonathan H Bentley, Jordan R Altman, Saurabh Hinduja, Nisha Giridharan, Garrett P Banks, Mohammed Hasen, Ben Shofty, Sarah R Heilbronner, Jeffrey F Cohn, David A Borton, Eric A Storch, Jeffrey A Herron, Benjamin Y Hayden, Mary L Phillips, Wayne K Goodman, Sameer A Sheth Sep 2025

High Beta Power In The Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study, Nicole R Provenza, Sameer V Rajesh, Gabriel Reyes, Kalman A Katlowitz, Lokesha S Pugalenthi, Raphael A Bechtold, Nabeel Diab, Sandesh Reddy, Anthony K Allam, Ajay D Gandhi, Katherine E Kabotyanski, Kasra A Mansourian, Jonathan H Bentley, Jordan R Altman, Saurabh Hinduja, Nisha Giridharan, Garrett P Banks, Mohammed Hasen, Ben Shofty, Sarah R Heilbronner, Jeffrey F Cohn, David A Borton, Eric A Storch, Jeffrey A Herron, Benjamin Y Hayden, Mary L Phillips, Wayne K Goodman, Sameer A Sheth

Faculty, Staff and Students Publications

Deep brain stimulation (DBS) of the ventral capsule and ventral striatum (VC/VS) is an effective therapy for treatment-resistant obsessive–compulsive disorder (trOCD). DBS initiation often produces acute improvements in mood and energy. These acute behavioral changes, which we refer to as “approach behaviors,” include increased social engagement and talkativeness. We investigated the relationship between stimulation amplitude, spectral power in the ventrolateral prefrontal cortex (vlPFC), and speech rate in one male patient with trOCD implanted with bilateral VC/VS DBS leads and subdural electrodes adjacent to the orbitofrontal cortex and vlPFC. Several times over the first 24 weeks of therapy, we conducted experiments …


At Stake In Each Other’S Company: A Systems View Of Compassion Fatigue In Mental Health Work, Susan S. Standen Sep 2025

At Stake In Each Other’S Company: A Systems View Of Compassion Fatigue In Mental Health Work, Susan S. Standen

Journal of Conscious Evolution

Traditional research on the phenomenon of compassion fatigue (CF) in mental health work tends to include recommendations for workers to build skills in psychological detachment and self-care. This puts the burden of coping with vicarious trauma on the individual caregiver, not on the systems they operate within. Alternatively, a transformative systemic perspective suggests that Western cultural assumptions about care-giving and individual resilience need to be reassessed. By broadening the exploration of CF and comparing it with human reactions to overwhelming crises across fields and disciplines, new questions can be asked, and new solutions can be proposed. This essay details how …


Wellington V. Lucien Sep 2025

Wellington V. Lucien

All Decisions

A landlord's motion to amend a petition to correct a misdescription of the premises was denied, leading to the dismissal of the holdover case. The court found that the misdescription, a violation of RPAPL § 741(3), was a fatal jurisdictional defect that could not be corrected, even though the parties had previously stipulated to a final judgment of possession. The tenant's cross-motion for harassment was also denied without prejudice, with the court advising the tenant to seek relief in a separate HP action, as the prior two-attorney stipulation of settlement had not addressed the harassment claims. The ruling highlights that …


Matter Of 145 Driggs, Llc V. New York State Div. Of Hous. & Community Renewal Sep 2025

Matter Of 145 Driggs, Llc V. New York State Div. Of Hous. & Community Renewal

All Decisions

The Appellate Division affirmed a lower court's judgment that upheld a DHCR determination in favor of a tenant in a rent overcharge proceeding. The court found that DHCR acted rationally in granting the tenant's complaint despite having previously denied a similar complaint from a prior tenant. The court held that the landlord's argument for deregulation was properly rejected and that the rent overcharge complaint was valid. The landlord's petition was denied, and the proceeding was dismissed.


Meier V. 451 W. Owners Ltd. Sep 2025

Meier V. 451 W. Owners Ltd.

All Decisions

In an HP proceeding, a landlord was held in civil contempt for failing to correct violations, leading to a $240,560 money judgment for civil penalties. The landlord moved to vacate the judgment and HPD's restraining notice. The court denied the motion to vacate the judgment, affirming its validity and rejecting arguments for its modification. However, the court did vacate the restraining notice, finding it **defective** for non-compliance with the notice requirements of **CPLR 5222**, but did so without prejudice. The ruling allows HPD to re-serve a proper notice to enforce the a valid judgment.


11114 101 Ave Corp. V. Ramlogan Sep 2025

11114 101 Ave Corp. V. Ramlogan

All Decisions

In this commercial holdover proceeding, the court denied the tenants' motion to reargue, affirming its prior decision that a summary proceeding can be brought against tenants at sufferance. The tenants argued that Article 7 of the RPAPL does not include tenants at sufferance as a class for which a summary proceeding is authorized, compelling the landlord to file an ejectment action in Supreme Court. The court rejected this, citing numerous precedents and reasoning that the language "recover possession" in RPL § 228 provides sufficient statutory basis for a summary proceeding in Housing Court.


Structure Of The T9ss Porkn Ring Complex Reveals Conformational Plasticity Based On The Repurposed Fge Fold, Xiangan Liu, John D Perpich, Liqiang Song, Christian Cambillau, Thierry Doan, Lei Zheng, Richard J Lamont, Eric Cascales, Bo Hu Sep 2025

Structure Of The T9ss Porkn Ring Complex Reveals Conformational Plasticity Based On The Repurposed Fge Fold, Xiangan Liu, John D Perpich, Liqiang Song, Christian Cambillau, Thierry Doan, Lei Zheng, Richard J Lamont, Eric Cascales, Bo Hu

Faculty, Staff and Student Publications

The type IX secretion system (T9SS) is a protein secretion machinery unique to the Bacteroidetes-Chlorobi-Fibrobacteres superphylum, which plays crucial roles in bacterial pathogenesis and gliding motility. It is composed of >15 proteins, including the proton-motive force-dependent PorLM motor, the PorKN ring anchored to the outer membrane, and the Sov translocon. Here, we present the cryo-electron microscopy (EM) structure of the PorKN ring complex from Porphyromonas gingivalis at 3.2 Å resolution. Our structural analysis reveals that PorK contains a repurposed formylglycine-generating enzyme-like fold, which serves as a structural hub for complex assembly rather than enzymatic activity. The complex exhibits a 33-fold …


Retinoid-X-Receptor As A Mediator Of Poststroke Recovery By Reversing Age-Associated Phenotypes Of Microglia/Hematogenous Macrophages, Shun-Ming Ting, Xiurong Zhao, Guanghua Sun, Mercedes Ricote, Jaroslaw Aronowski Sep 2025

Retinoid-X-Receptor As A Mediator Of Poststroke Recovery By Reversing Age-Associated Phenotypes Of Microglia/Hematogenous Macrophages, Shun-Ming Ting, Xiurong Zhao, Guanghua Sun, Mercedes Ricote, Jaroslaw Aronowski

Faculty, Staff and Student Publications

After stroke, microglia and hematogenous macrophages, together referred to as MΦ, clear dead cells and cellular debris in the infarcted brain through phagocytosis as an essential part of the recovery process. However, the phagocytic capability of MΦ declines with age. Furthermore, aged MΦ become overactivated in response to stroke, enhancing secondary brain injury. In this study, we demonstrated that by reversing the age-related dysfunctions in MΦ through activating the retinoid X receptor (RXR), the recovery after stroke in the aged brain could be improved. Using RNA-sequencing, we compared the transcriptomes between MΦ isolated from the brains of young and aged …