Digital Commons Network^™

Presenting The Jacob Burns Center Award For Professional Courage To Elizabeth (Liz) Oyer, Jacob Burns Center For Ethics In The Practice Of Law, Elizabeth (Liz) Oyer

2025 Event Invitations

Liz Oyer served in the Department of Justice as United States Pardon Attorney from April 2022 to March 2025, overseeing the Office of the Pardon Attorney. In that role, she was responsible for reviewing applications from individuals across the country seeking pardons and commutations of sentence and preparing recommendations for the President concerning the exercise of his constitutional clemency power. The Pardon Attorney is a career-reserved position in the Senior Executive Service; it is not a political appointment.

Underwater Acoustic Integrated Sensing And Communication: A Spatio-Temporal Freshness For Intelligent Resource Prioritization, Ananya Hazarika, Mehdi Rahmati

Electrical and Computer Engineering Faculty Publications

Underwater acoustic communication faces significant challenges including limited bandwidth, high propagation delays, severe multipath fading, and stringent energy constraints. While integrated sensing and communication (ISAC) has shown promise in radio frequency systems, its adaptation to underwater environments remains challenging due to the unique acoustic channel characteristics and the inadequacy of traditional delay-based performance metrics that fail to capture the spatio-temporal value of information in dynamic underwater scenarios. This paper presents a comprehensive underwater ISAC framework centered on a novel Spatio-Temporal Information-Theoretic Freshness metric that fundamentally transforms resource allocation from delay minimization to value maximization. Unlike conventional approaches that treat all …

Punitiveness In The Modern Era: Gender Roles & Anti-Transgender Attitudes, Haley Brooke Trantham

Theses and Dissertations

Public opinion on punitiveness is an important topic of study because it can influence political elites’ decision making when developing legislation. This study focused on the role gender ideology and anti-transgender attitudes on punitiveness while controlling for religious and political conservatism. The 2020 American National Election Study (ANES) was used to examine the association between conservatism, traditional gender roles, and anti-transgender attitudes on their influence of punitiveness. Three ordinal logistic regressions were run for each type of punitiveness (i.e., death penalty support, crime spending, and felon disenfranchisement). Results indicated that religious conservatives had lesser odds for supporting the death penalty …

Whole Genome Sequence Analysis Of Low-Density Lipoprotein Cholesterol Across 246 K Individuals, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Eric Van Buren, Sara Haidermota, Darina Postupaka, Whitney Hornsby, Joshua C Bis, Jennifer A Brody, Brian E Cade, Ren-Hua Chung, Joanne E Curran, Scott M Damrauer, Lisa De Las Fuentes, Paul S De Vries, Ravindranath Duggirala, Barry I Freedman, Mariaelisa Graff, Xiuqing Guo, Bertha A Hidalgo, Lifang Hou, Ryan Irvin, Renae Judy, Rita R Kalyani, Tanika N Kelly, Iain R Konigsberg, Brian G Kral, Lydia Coulter Kwee, Daniel Levy, Changwei Li, Ani W Manichaikul, Lisa Warsinger Martin, May E Montasser, Alanna C Morrison, Take Naseri, Kari E North, Jeffrey R O'Connell, Nicholette D Palmer, Patricia A Peyser, Alex P Reiner, Svati H Shah, Roelof A J Smit, Jennifer A Smith, Kent D Taylor, Hemant Tiwari, Michael Y Tsai, Satupa'itea Viali, Zhe Wang, Yuxuan Wang, Wei Zhao, Donna K Arnett, John Blangero, Eric Boerwinkle, Donald W Bowden, Jenna C Carlson, Yii-Der Ida Chen, Patrick T Ellinor, Myriam Fornage, Jiang He, Nancy Heard-Costa, Robert C Kaplan, Sharon L R Kardia, Charles Kooperberg, William E Kraus, Leslie A Lange, Ruth J F Loos, Braxton D Mitchell, Bruce M Psaty, Daniel J Rader, Susan Redline, Stephen S Rich, Lisa R Yanek, Richard Gibbs, Stacey Gabriel, Karine A Viaud-Martinez, Susan K Dutcher, Soren Germer, Ryan Kim, Jerome I Rotter, Xihong Lin, Gina M Peloso, Pradeep Natarajan

The Brown Foundation: Institute of Molecular Medicine

Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larger sample sizes from diverse cohorts, thereby increasing the likelihood of discovering novel insights into complex traits. Furthermore, emerging methods in genome-wide rare variant association testing further improve power and interpretability.

Results: Here, we conduct the largest meta-analysis of whole genome sequencing for low-density lipoprotein cholesterol (LDL-C), a therapeutic target for coronary artery disease, analyzing data from 246 K participants and integrating 1.23B variants from the UK Biobank and the Trans-Omics …

Sleep Architecture And Dementia Risk In Adults: An Analysis Of 5 Cohorts From The Sleep And Dementia Consortium, Stephanie Yiallourou, Andree-Ann Baril, Crystal Wiedner, Jeffrey R Misialek, Christopher E Kline, Stephanie Harrison, Ethan Cannon, Qiong Yang, Rebecca Bernal, Alycia Bisson, Dibya Himali, Marina Cavuoto, Antoine Weihs, Alexa Beiser, Rebecca F Gottesman, Yue Leng, Oscar Lopez, Pamela L Lutsey, Shaun M Purcell, Susan Redline, Sudha Seshadri, Katie L Stone, Kristine Yaffe, Sonia Ancoli-Israel, Qian Xiao, Eleni Okeanis Vaou, Jayandra J Himali, Matthew P Pase

Faculty, Staff and Student Publications

Study objectives: Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium.

Methods: Percent of time spent in stages of sleep (N1, N2, N3, rapid eye movement sleep), wake after sleep onset, sleep maintenance efficiency, apnea-hypopnea index, and relative delta power were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox …

Fellin V. Martinez

All Decisions

In this licensee holdover proceeding, the tenant moved to dismiss the petition, arguing it was defective for failing to state why the premises were exempt from the New York Good Cause Eviction Law (GCEL) and for not disclosing the number of units owned by the landlord and their addresses, as required by Real Property Law (RPL) § 214 and RPAPL § 741. The court granted the tenant's motion, dismissing the proceeding without prejudice, finding the landlord failed to comply with RPL § 214 by not providing the required ownership information for a "small landlord" GCEL exemption claim.

Ed Rust '72 To Headline Inaugural Kinder Brothers Speaker Series, Chris Francis

News and Events (Discontinued Series)

No abstract provided.

Iwu Welcomes Largest Incoming Class In 15 Years, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Corrigendum To "Trustworthiness Criteria For Meta-Analyses Of Randomized Controlled Studies: Obgyn Journal Guidelines" [Ejogrb 305 (2025) 416-418], Vincenzo Berghella

Department of Obstetrics and Gynecology Faculty Papers

Participating members of the OBGYN Editors’ Integrity Group (OGEIG) All OGEIG members who participated in meetings discussing the manuscript ‘Trustworthiness criteria for meta-analyses of randomized controlled studies’ are listed here, with their affiliated journal/organization in parentheses: Jason Abbott (J Minim Invasive Gynecol), Ganesh Acharya (Acta Obstet Gynecol Scand), Amir Aviram (Am J Obstet Gynecol MFM), Kurt Barnhart (Fertil Steril), Vincenzo Berghella (Am J Obstet Gynecol MFM), Catherine S. Bradley (Am J Obstet Gynecol), Nancy Chescheir (COPE), Thomas D'Hooghe (Gynecol Obstet Invest), Michael Geary (Int J Gynecol Obstet), Janesh Gupta (Eur J Obstet Gynecol), Karl Oliver Kagan (Arch Gynecol Obstet), Anthony …

The Effects Of Tfeα And Promoter Sequence On Early Events In Archaeal Transcription Initiation, Madolyn Toli

Dissertations and Theses

Expression of genes is dependent on promoter sequences in DNA, which direct transcription by RNA polymerase. Transcription factors interact with promoters and RNAP and are often conserved and are essential for proper gene expression. In this thesis, a functional region of archaeal TFEα, homologous to eukaryotic TFIIEα, has been identified, and specific amino acids in these regions have been determined to have significant importance in TFEα's ability to promote transcription in early initiation. All three Domains of life encode a 16S rRNA promoter, which is responsible for production of the 16S portion of ribosome. Transcription with this promoter is not …

Association Between Conversational Multitasking And Clinician Work Behaviors At A Large Us Health Care System: Cohort Study, Linlin Xia, Daphne Lew, Laura Baratta, Elise Eiden, Sunny Lou, Thomas Kannampallil

2020-Current year OA Pubs

BACKGROUND: Clinical communication is central to the delivery of effective, timely, and safe patient care. The use of text-based tools for clinician-to-clinician communication-commonly referred to as secure messaging-has increased exponentially over the past decade. The use of secure messaging has a potential impact on clinician work behaviors, workload, and cognitive burden.

OBJECTIVE: The objective of this study is to investigate the relationship between conversational multitasking-engaging in multiple concurrent, text-based secure messaging conversations-and clinician workload and cognitive burden for inpatient care.

METHODS: This observational cohort study included attending physicians, trainee physicians, and advanced practice providers who worked in an inpatient setting …

Metabolic Rewiring Of Isoniazid Sensitivity In Mycobacterium Tuberculosis, Erin R Wang, Kevin Cho, Gregory A Harrison, Asya Smirnov, Samuel R Mckee, George S Ghabrial, Kelly N Flentie, Wandy Beatty, Thomas Hurtaux, Liza Loza, Tamara L Doering, Gary J Patti, Christina L Stallings, Et Al.

2020-Current year OA Pubs

Isoniazid (INH) inhibits mycolic acid synthesis in

Fatty Acid 2-Hydroxylase Facilitates Rotavirus Uncoating And Endosomal Escape, Enkai Li, Ruochen Zang, Takahiro Kawagishi, Wei Zhang, Kruthika Iyer, Gaopeng Hou, Qiru Zeng, Rita M Meganck, Susan R Ross, Xin Wang, Xiong Su, Siyuan Ding

2020-Current year OA Pubs

Despite the clinical significance of many nonenveloped viruses, the molecular mechanisms of their internalization and membrane penetration are not well understood. Rotaviruses (RVs) are nonenveloped double-stranded RNA viruses and the leading cause of severe dehydrating diarrhea in infants and young children. We identified fatty acid 2-hydroxylase (encoded by

Community Engagement Studios To Improve Racial Diversity And Health Equity In Parkinson's, Eunyoung Kang, Dominique Woodhouse, Kandace Davis, Jane Q Yap, Peter S Myers, Meghan C Campbell, Yvonne D Hughes, Joyce E Balls-Berry, Erin R Foster

2020-Current year OA Pubs

BACKGROUND: Black or African Americans (AA) with Parkinson's disease (PD) are underrepresented in both care and research and experience significant health disparities. The existing literature provides limited guidance on how to enhance the engagement of AA individuals in PD care and research, particularly from the perspectives of AA patients, care partners, and healthcare providers. This project aimed to (1) describe the use of Community Engagement (CE) Studios as a community-engaged research approach to inform culturally appropriate and inclusive research and (2) examine factors influencing AA engagement in PD-related activities.

METHODS: We conducted three CE Studios: one with AA with PD …

Stayin' Alive (Even Without Oxygen): Retinal Development In Austrofundulus Limnaeus, Carmen Zecilia Rodriguez

Dissertations and Theses

The vertebrate eye is one of the most metabolically active organs in the body and is particularly sensitive to environmental stressors such as oxygen deprivation. Understanding how eye development proceeds under such conditions can provide critical insights into mechanisms of cellular resilience, tissue organization, and developmental plasticity. The annual killifish Austrofundulus limnaeus represents a unique model for investigating these processes due to its remarkable tolerance to anoxia during embryogenesis. However, the wild-type form is heavily pigmented, limiting the effectiveness of traditional imaging techniques for studying eye development. This thesis characterizes eye development and anoxia resilience in both wild-type and melanin-deficient …

Impact Of Black Shale Weathering On Stream Water And Sediment Quality In Eastern Kentucky, Brett Hopt

Dissertations and Theses

Black shales contain high concentrations of trace elements in addition to their elevated organic carbon content. Once exposed at the surface, weathering processes release these elements into the environment, including many (e.g., As, Cu, Cd, Cr, U, Zn) that could pose threats to human and environmental health. Previous studies have focused on how these metals are incorporated into the soil column and their effects on crop nutrition. However, few studies have focused on the impact of natural weathering of black shales on local stream water chemistry and the transport and subsequent partitioning of these geogenic contaminants into stream environments.

This …

Integrative Techniques To Alleviate Abiotic Stress In Plants Using Plant Growth Promoting Bacteria And Fungi: Mechanisms, Interactions, And Applications, Muhammad Naseem, Amjad Iqbal, Muhammad Qadir, Anwar Hussain

All Works

No abstract provided.

Spartan Daily, September 9, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 7

Computationally Resolved Neuroprogenitor Cell Biomarkers Associate With Human Disorders, Gerarda Cappuccio, William T Choi, Fatih Semerci, Jill A Rosenfeld, Toni Claire Tacorda, Guantong Qi, Anthony W Zoghbi, Yi Zhong, Hu Chen, Pengfei Liu, Zhandong Liu, Mirjana Maletić-Savatić

Duncan NRI Faculty and Staff Publications

Adult hippocampal neurogenesis, the process of generating new neurons, relies on a rare population of neural stem and progenitor cells (NPCs) within the dentate gyrus complex microenvironment. Discovering the specific genes that define these cells is vital yet challenging due to overlapping expression patterns, limiting detection of rare cell populations using traditional approaches. By employing the computational digital sorting algorithm (DSA) that deconvolves complex gene expression data based on pattern recognition, we identified 129 genes enriched in murine NPCs. We validated these genes against published single-cell RNA sequencing (scRNA-seq) data and discovered that 25 human orthologs were known to cause …

Creativity And Nerd Culture Coram Deo, Brad D. Hickey

Faculty Work Comprehensive List

"... our play, whether serious or non-serious, should be a part of our greater efforts to consecrate our lives to God."

Posting about ­­­­­­­­human flourishing in the gaming world from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Creativity and Nerd Culture Coram Deo

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Questions Worth Asking: Un-Disciplining Archaeology, Reclaiming Pasts For Better Futures, Nathan P. Acebo, Wade Campbell, Edward González-Tennant, Alicia Odewale, Emily Van Alst, William A. White, Stephen A. Mrozowski, Lindsay M. Montgomery, Craig N. Cipolla, Anna S. Agbe-Davies

Anthropology Faculty Publications

This forum engages an emerging discourse around historical reckoning, truth, and reconciliation, asking how these frameworks inform American archaeology and its future. A growing number of archaeologists are now demanding systemic disciplinary transformations that directly address how white supremacy and settler colonialism enact Indigenous dispossession and erasure as well as anti-Blackness, gender discrimination, and ableism. This forum, featuring 10 archaeologists—including a mixture of junior- and senior-level scholars—is organized into thematic dialogues that highlight their different perspectives and experiences within North American cultural heritage management. First, the dialogue interrogates American archaeology’s embeddedness in ethnocentrism and racism. It then looks at different …

A Phase 2 Study Of Obinutuzumab Combined With Lenalidomide In Previously Untreated High Tumor Burden Follicular Lymphoma, Neha Akkad, Lei Feng, Jason R Westin, Fredrick B Hagemeister, Hun Ju Lee, Luis Fayad, Sairah Ahmed, Ranjit Nair, Maria Alma Rodriguez, Paolo Strati, Dai Chihara, Christopher R Flowers, Linda Claret, Karina Ibanez, Michael Wang, Nathan H Fowler, Jared Henderson, R Eric Davis, Sattva S Neelapu, Michael Green, Loretta J Nastoupil

Faculty, Staff and Student Publications

Follicular lymphoma (FL) has a clinical course that is often characterized by high response rates to first-line therapy, followed by multiple relapses over a prolonged natural history. Currently, there are multiple possible approaches to frontline therapy for untreated advanced-stage FL, but there is an ongoing debate around what is the preferred approach. Based on the benefits seen with combining lenalidomide, an immunomodulatory agent, with rituximab, an anti-CD20 antibody, we aimed to evaluate the safety and efficacy of lenalidomide in combination with obinuzutumab, an anti-CD20 antibody with enhanced antibody-dependent cellular cytotoxicity. The eligibility criteria included a diagnosis of FL, grade 1 …

Multidimensional Arbitration, Cary Deck, Paul Pecorino, Brian R. Powers

ESI Working Papers

Most analyses of arbitration consider disputes over a single dimensional issue; however, in many situations more than one issue can be in dispute. In a labor context, the parties may disagree on the hourly wage, number of paid holidays, and fringe benefits as well as other conditions of employment. In addition to conventional arbitration (CA), two variants of multidimensional final-offer arbitration (FOA) are employed in practice. Under one version of FOA, the arbitrator must pick the entire package submitted by one of the disputants. Under the other version of FOA, the arbitrator can select elements from each disputant’s final offer …

Fruquintinib In Less Pretreated Patients: Multivariate Profile-Matching Analysis Of Fresco-2 To Fresco, Arvind Dasari, Cathy Eng, Sara Lonardi, Rocio Garcia-Carbonero, Toshiki Masuishi, Chiara Cremolini, François Ghiringhelli, Joleen Hubbard, Tanios Bekaii-Saab, Jeremy Jones, Rui-Hua Xu, Lin Shen, Jianming Xu, Yuxian Bai, Yanhong Deng, Ying Yuan, Wei Wei, Jianchang Lin, Lucy Chen, Zhao Yang, William R Schelman, Shukui Qin, Jin Li

Faculty, Staff and Student Publications

Background: In the phase 3 FRESCO (NCT02314819) and FRESCO-2 (NCT04322539) studies, fruquintinib vs placebo, plus best supportive care, significantly improved overall survival (OS) in patients with metastatic colorectal cancer (mCRC). These studies were conducted in temporally and geographically diverse populations that received distinct prior therapies; FRESCO patients were less pretreated than FRESCO-2 patients. This analysis assessed the efficacy and safety of fruquintinib in a less pretreated global population than the FRESCO-2 intention-to-treat (ITT) population.

Methods: In FRESCO and FRESCO-2, patients were randomized 2:1 to receive oral fruquintinib 5 mg or matched placebo. Profile matching was undertaken …

Therapeutic Restoration Of Mitochondria-Endoplasmic Reticulum Cross Talk For Osteoarthritis, Mingzhuang Hou, Yifan Ma, Yaoge Deng, Yubin Wu, Yanrun Zhu, Yang Liu, Xiaoping Li, Lili Yu, Zirui He, Yifan Wang, Shiyan Dong, Xiaowei Xia, Jianfeng Yu, Chenqi Yu, Kang Kang, Yingjie Lu, Lili Sun, Betty Y S Kim, Yuan Yuan, Yijian Zhang, Wen Jiang, Xuesong Zhu

Faculty, Staff and Student Publications

Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondrocyte homeostasis and whether such processes can be explored as therapeutic targets for osteoarthritis remain unclear. Here, we show that impaired mitochondrial function and disrupted cartilage matrix metabolism due to loss of mitofusin-2 (MFN2) expression in chondrocytes leads to the development of osteoarthritis. Sirtuin-3 (SIRT3), a key regulator of mitochondrial function, plays a critical role in modulating MFN2 to restore mitochondrial dynamics, reduce …

19 W. 89th St. Llc V. Cornine

All Decisions

In this ejectment action, the court granted the landlord's motion for summary judgment, awarding $114,036.68 in use and occupancy and possession of the rent-stabilized apartment. The tenant's various defenses, including claims of a defective rent demand, issues with the landlord's corporate name, an invalid renewal lease, and breach of the warranty of habitability, were all rejected. The court found that the tenant owed rent arrears from February 2018. The tenant's cross-motion to amend the answer to add affirmative defenses and a counterclaim was denied as unmeritorious. The court emphasized that the landlord sought possession due to non-payment, not the tenant's …

Mcmanus Realty Servs., Llc V. Ilabaca

All Decisions

In a holdover proceeding alleging a tenant breached their lease by making unauthorized alterations, the court dismissed the case. The court found that the predicate notice to cure and notice of termination were defective as a matter of law because they failed to cite any specific lease provision that was allegedly breached. The court rejected the landlord's argument that such a provision "undoubtedly" existed, stating that the landlord-tenant relationship is created by a contract and the court cannot assume the existence of a term without the agreement itself.

Endothelin B Receptor Inhibition Rescues Aging-Dependent Neuronal Regenerative Decline, Rui Feng, Sarah F Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cedric G Geoffroy, Valeria Cavalli

2020-Current year OA Pubs

Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood. While excessive production of endothelin 1 (ET-1), a potent vasoconstrictor, is linked to many diseases that increase with age, the role of ET-1 and its receptors in axon regeneration is unknown. Using single-cell RNA sequencing, we show that satellite glial cells (SGCs), which completely envelop the sensory neuron soma residing in the dorsal root ganglia (DRG), express the endothelin B receptor (ETBR), while ET-1 is expressed by endothelial cells. Inhibition of ETBR ex vivo …

Exploring The Landscape Of Teacher Applications, Dan Goldhaber, Cyrus Grout, Constance A. Lindsay, Elton Mykerezi, Aaron Sojourner, Lauren Dachille

Upjohn Institute Working Papers

Despite widespread concern about teacher shortages, there is little evidence on when teaching positions are posted and how many people apply for them. Using detailed job-posting and application data on nearly 57,000 applicants from 19 traditional school districts and 24 charter organizations, we provide descriptive evidence on the timing of job postings, the supply of applicants, and the characteristics of applicants, emphasizing how each varies across organizations and between the district and charter sectors. We find that late hiring is less prevalent than prior single-district studies suggest—about 11% of openings are posted late—but varies widely across organizations. Applicant supply differs …