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Point Of Care Ultrasound (Pocus): No Hocus Among Anesthesiologists, Natalie A. Brin, Andrea Camila Marcano-Rodriguez, Muhamed Jaber, Grace Victoria Faberlle, Ryan Singh Sep 2025

Point Of Care Ultrasound (Pocus): No Hocus Among Anesthesiologists, Natalie A. Brin, Andrea Camila Marcano-Rodriguez, Muhamed Jaber, Grace Victoria Faberlle, Ryan Singh

OneUSF Undergraduate Research Conference

Andrea Camila Marcano-Rodriguez, Natalie Andrade Brin, Muhamed Muntaser Jaber, Grace Victoria Faberlle, Ryan Singh Faculty Mentor: Dr. Donna Lee Ettel-Gambino (Judy Genshaft Honors College) An anesthesiologist’s ability to recognize the intrinsic utility of Point of Care Ultrasound (POCUS) as a diagnostic tool may improve patient safety, decrease anesthesia time, and maximize patient outcomes.1 Evidence suggests that POCUS is a safe, inexpensive, non-invasive, portable, and easily accessible perioperative tool. The purpose of study was to identify the anesthesiologists’ systems and processes for clinical decision-making utilizing POCUS for patients during the perioperative phases of care. A MANOVA was conducted to identify differences …

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Economic Impact Of Nicotine Addiction: A Multi-Stakeholder Cost Analysis, Shikha Patel Sep 2025

Economic Impact Of Nicotine Addiction: A Multi-Stakeholder Cost Analysis, Shikha Patel

OneUSF Undergraduate Research Conference

Extensive research has examined the health consequences of nicotine addiction, but economic analyses incorporating multiple stakeholder perspectives remain scarce. This study quantifies the annual financial burden of nicotine addiction across users, employers, and insurers. A systematic analysis was conducted on direct and indirect costs, utilizing data from the Centres for Disease Control and Prevention (CDC), Bureau of Labor Statistics, and insurance industry reports (2022-2024). The financial impact was assessed for each stakeholder, including consumption expenses, productivity losses, healthcare utilization, and insurance claims. The estimated annual economic burden of nicotine addiction was ₹1,773.4 billion in India, while in the U.S., costs …

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Effects And Risks Of Pediatric Malnutrition On Neurodevelopmental Disorders And Cognitive Decline, Aminata A. Thiam, Ana M. Beatriz, Katie-Linn Poindexter, Mandy Jiang, Maxx Struhs, Valerie Vargas Ardila Sep 2025

Effects And Risks Of Pediatric Malnutrition On Neurodevelopmental Disorders And Cognitive Decline, Aminata A. Thiam, Ana M. Beatriz, Katie-Linn Poindexter, Mandy Jiang, Maxx Struhs, Valerie Vargas Ardila

OneUSF Undergraduate Research Conference

Malnutrition during early childhood is a significant risk factor for neurodevelopmental disorders (NDD) and cognitive decline (CD), with lasting effects into adulthood. Deficiencies in essential nutrients, such as vitamins, minerals, and fatty acids, hinder the proper development of the brain, leading to issues such as attention deficits, cognitive delays, and neurological disabilities. This project aims to examine the effects of pediatric malnutrition on neurodevelopmental outcomes and assess the metrics used to analyze cognitive outcomes in pediatric patients. Utilizing electronic databases such as PubMed and JAMA Network, a systematic literature review was conducted to evaluate the impact of CD and NDD …

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Government Expenditure On Education And Its Impact On Access To Higher Education In The U.S. And Germany, Miguel Barrero Garcia, Minh Anh Nguyen Sep 2025

Government Expenditure On Education And Its Impact On Access To Higher Education In The U.S. And Germany, Miguel Barrero Garcia, Minh Anh Nguyen

OneUSF Undergraduate Research Conference

On the surface level there seems to be a discrepancy between access to higher education in the U.S. and Germany, so we would like to explore its connection with government expenditure on education. How does government spending on education in Germany and the U.S. differ and how does it shape access to higher education? The research is being conducted by going over different studies on how each country’s government treats education and spends on it. Research will also be done on access to higher education in both countries and what other factors, aside from government expenditure on education, could affect …

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A Comparative Analysis Of Healthcare Systems: The United States And Germany, Catherine Ugwu, Belinda Solis Sep 2025

A Comparative Analysis Of Healthcare Systems: The United States And Germany, Catherine Ugwu, Belinda Solis

OneUSF Undergraduate Research Conference

Healthcare systems around the world can differ significantly in areas such as their structure and accessibility. This study compares key aspects of the German and American healthcare systems, focusing on an unbiased comparison of the two. Germany’s healthcare system, grounded in its Basic Law of “Grundgesetz”, ensures universal access to medical care using their main system of statutory health insurance (SHI) and private insurance. In contrast, the U.S. operates a fragmented healthcare system characterized by a mix of private and public insurance, leading to significant disparities in coverage and costs. By analyzing these differences, this study highlights the strengths and …

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Impact Of Background Music In Information Retention Techniques On Short-Term Memory In Engineering Students, Eduardo Barbosa Sanchez, Beatriz Primo E Silva, Ana Carolina Rezende Neves Sep 2025

Impact Of Background Music In Information Retention Techniques On Short-Term Memory In Engineering Students, Eduardo Barbosa Sanchez, Beatriz Primo E Silva, Ana Carolina Rezende Neves

OneUSF Undergraduate Research Conference

The relationship between background music and memory retention is a growing area of interest, particularly among students who frequently use music during study sessions. According to the Journal of Higher Education Theory and Practice, around 75% of students listen to music while studying. Based on a Harvard publication, understanding short-term memory is essential for study efficiency, as it is influenced by word exposure modes, auditory environments, and individual factors. This study investigates the impact of auditory environments on short-term memory retention in College of Engineering students aged 18–25. Using a within-subject factorial design combined with a Randomized Complete Block Design, …

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Machine Learning Insights Into Multilingual Children's English Reading Achievement: Evaluating The Predictive Power Of Kindergarten Factors On Elementary English Reading Achievement, Nam Nguyen Sep 2025

Machine Learning Insights Into Multilingual Children's English Reading Achievement: Evaluating The Predictive Power Of Kindergarten Factors On Elementary English Reading Achievement, Nam Nguyen

OneUSF Undergraduate Research Conference

Existing machine learning research that examines factors influencing student’s academic achievement largely focuses on monolingual rather than multilingual students. To address this gap, we employ machine learning to analyze the Early Childhood Longitudinal Study, Kindergarten Class of 2010-11 (ECLS-K:2011) data of 3,542 nationally representative multilingual children from 970 U.S. schools, who were followed from kindergarten (Fall 2010) to 5th grade (Spring 2016). Our study models and compares the predictive power of six key factors in kindergarten (early reading ability, cognitive and language skills, socio-emotional skills, child characteristics, home literacy environment, and school/classroom characteristics) on English reading achievement across primary years. …

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Assessing The Effectiveness And Implementation Of Artificial Intelligence In Detecting And Preventing International Financial Crimes: A Case Study Of The United Kingdom, Robert J. Dalton Sep 2025

Assessing The Effectiveness And Implementation Of Artificial Intelligence In Detecting And Preventing International Financial Crimes: A Case Study Of The United Kingdom, Robert J. Dalton

OneUSF Undergraduate Research Conference

Financial crime has been an issue that has plagued the world for as long as the concept of trade has existed. With the rise of the digital age and globalization, financial crime has continuously and significantly evolved, with increasingly complex and intricate methods of financial crime and fraud being committed each year. Government organizations and financial institutions are having to constantly overcome new barriers and challenges to monitor financial crimes due to their evolving nature. Artificial intelligence, a new technology that is being constantly researched and explored, has the potential to innovate current and new technologies within the financial intelligence …

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L-Ergothioneine Shows Benefits In Reducing Age-Related Hearing Loss: Improved Signal-In-Noise Detection In Mice, Evin Roji, Muhammad Hassam Amir Sep 2025

L-Ergothioneine Shows Benefits In Reducing Age-Related Hearing Loss: Improved Signal-In-Noise Detection In Mice, Evin Roji, Muhammad Hassam Amir

OneUSF Undergraduate Research Conference

The amino acid, L-ergothioneine (EGT), has gained attention as a potential therapeutic for age-related conditions due to its antioxidant and antiinflammatory properties. EGT is naturally found in various foods and shows promise in protecting against oxidative stress, inflammation, and neurodegeneration. Recent studies have highlighted its role in improving physiological functions in aging models, particularly in mitigating age-related declines in sensory and neurological systems. In this study, we aimed to investigate whether long-term oral administration of EGT via gavage could improve hearing function in aged mice. Hearing sensitivity and signal-in-noise detection were measured to determine the therapeutic potential of EGT for …

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Barry Jenkins' Moonlight: Reimagining The Coming-Of-Age Genre In Film, Jonathan R. Davis Sep 2025

Barry Jenkins' Moonlight: Reimagining The Coming-Of-Age Genre In Film, Jonathan R. Davis

OneUSF Undergraduate Research Conference

The coming-of-age genre in film was established during the 1950s, a postwar period defined by rebellious and confused teenagers. Within the film genre, the young protagonist experiences physical or emotional struggle throughout their expedition, resulting in organic identity discovery. One subdivision of the genre that emerged during the 1990s was black coming-of-age stories. However, it was not until Barry Jenkins’ 2016 film Moonlight that the genre was completely reimagined in a new light. Jenkins’ film does not follow the recurrent coming-of-age plotline that has been exemplified in previous films of the genre, which display youthful growth by the end. …

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Replication Fork Remodeling Curtails Dna Synthesis During Excessive Origin Firing, Thanh Le Sep 2025

Replication Fork Remodeling Curtails Dna Synthesis During Excessive Origin Firing, Thanh Le

OneUSF Undergraduate Research Conference

DNA replication is a faithful and accurate process during S-phase in each cell division. Errors in replication can potentially lead to cancer, highlighting the purpose of studying mechanisms of DNA replication. There are many challenges that cause DNA damage, making replication fork regulation essential to protect genome integrity. When cell misregulate during replication, it can result in re-replication, which replication origins are re-licensed and fired again. This leads to stress induced DNA breaks, activating cell cycle checkpoints and apoptosis, which cancer cells try to evade, making it a potential chemotherapy target. While re-replication is a source of genomic instability, re-replication …

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Parental Internalizing Symptoms And Parenting Behaviors: The Moderating Role Of Social Support, Anh Van Nguyen Sep 2025

Parental Internalizing Symptoms And Parenting Behaviors: The Moderating Role Of Social Support, Anh Van Nguyen

OneUSF Undergraduate Research Conference

“It takes a village to raise a child”. Social support is vital to parents in carrying out child-rearing duties, which is an additional source of stress for parents. Parents who exhibit higher levels of internalizing symptoms (e.g., depression, anxiety, stress) are more likely to engage in negative parenting behaviors. These behaviors can, in turn, negatively impact child development. Therefore, it is essential to investigate whether greater social support can buffer or attenuate the relationship between parental internalizing symptoms and negative parenting practices. Understanding this potential moderating effect is particularly important given the central role of parenting in shaping children’s developmental …

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Evolutionary Conservation And The Role Of Foxp2 In Human Speech And Language Development, Keira N. Ballard Sep 2025

Evolutionary Conservation And The Role Of Foxp2 In Human Speech And Language Development, Keira N. Ballard

OneUSF Undergraduate Research Conference

The study of genes offers a crucial understanding in the evolution of species and the many abilities an organism may have, including language. The FOXP2 gene encodes for the protein forkhead box P2, a transcription factor that is active in the development of speech and language during embryogenesis. Several single-nucleotide polymorphisms of this gene in humans have been linked to the speech and language disorder, childhood apraxia of speech, further supporting the gene’s role in human speech and language. The FOXP2 gene is highly conserved across vertebrates, even in species with limited vocalizations. This is particularly true among humans, chimpanzees, …

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Insights On Aapeptides As They Relate To Inhibiting The P300 Ch1 Domain, Tyler Lambert Sep 2025

Insights On Aapeptides As They Relate To Inhibiting The P300 Ch1 Domain, Tyler Lambert

OneUSF Undergraduate Research Conference

The HIF-1 pathway helps sustain cancerous tumors by preventing tumor cells from becoming necrotic. The histone acetyltransferase p300 protein is a vital coactivator used in the HIF-1 (hypoxia inducible factor) pathway by binding to subunit HIF-1a. Within our lab we aim to use novel AApeptides as a means of competitively inhibiting the p300 coactivator from binding to the HIF-1a subunit. In order to do this we are specifically studying the protein protein interactions of the CH1 (cysteine/histidine rich-1) domain of the p300 protein as it binds to the C-terminal transactivation domain of the HIF-1a subunit. The p300 CH1 domain is …

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Evaluating Impact Of Congenital Zika Virus Infection On Reproductive Health And Neonatal Outcomes In Latin America, Adrianna Soto, Maria Ivanova, Amanda Chinea, Daniela Davila, Ana Laura Alcantara Nascimento, Michelle Rodriguez, Valerie Vargas Ardila Sep 2025

Evaluating Impact Of Congenital Zika Virus Infection On Reproductive Health And Neonatal Outcomes In Latin America, Adrianna Soto, Maria Ivanova, Amanda Chinea, Daniela Davila, Ana Laura Alcantara Nascimento, Michelle Rodriguez, Valerie Vargas Ardila

OneUSF Undergraduate Research Conference

Congenital Zika virus syndrome (CZS) represents a severe and multifaceted outcome of Zika virus (ZIKV) infection during pregnancy, with far-reaching implications for both maternal and neonatal health. ZIVK, transmitted through the Aedes aegypti mosquito vector, has been linked to a range of birth defects, most notably microcephaly. CZS also increases the risk of other complications such as stillbirth, miscarriage, neonatal death, and a spectrum of congenital malformations. Between 2015 and 2016, over 2,000 confirmed cases of microcephaly linked to ZIVK were reported in Brazil, underscoring the epidemic as a public health crisis, particularly in Latin America, where environmental and socio-economic …

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The Role Of Estrogen In Lung Health, Aishwarya Aggarwal, Pooja Shree Mohann, Darshana Srivatsava, Jiya Patel Sep 2025

The Role Of Estrogen In Lung Health, Aishwarya Aggarwal, Pooja Shree Mohann, Darshana Srivatsava, Jiya Patel

OneUSF Undergraduate Research Conference

Estrogen, a key sex hormone, significantly influences lung health by modulating inflammation, immune responses, and disease progression. It impacts over 50% of women worldwide, yet the precise mechanisms underlying these effects remain misunderstood. This study evaluates how estrogen influences inflammation and disease progression in lung health, focusing on hormonal imbalances. A systematic review of PubMed and Scopus peer-reviewed literature (2000–2024) was performed. Thirty studies were selected considering their relevance for the role of estrogen in asthma, inflammation, lung cancer, and fibrosis. Studies that were included were experimental models to study estrogen receptors and hormonal effects on disease severity. Experiments also …

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Exploring Marine Microbial Products: Targeting Medical Bacteria In Little Bayou Bay, Shivam Anil Patel Sep 2025

Exploring Marine Microbial Products: Targeting Medical Bacteria In Little Bayou Bay, Shivam Anil Patel

OneUSF Undergraduate Research Conference

This study focuses on the identification and curation of microbial natural products, with a specific interest in their potential to target medical-related bacteria. The environment of the Little Bayou Bay was sandy with dirt near alley water that goes out to the Little Bayou Bay. The depth of sample was collected can have different pH level, and bacteria that live in the area. Understanding these reasons why microbial natural target medical-related bacteria can open numerous treatment options. The goal of the research lab is to isolate a bacterium from a sample from Little Bayou Bay. During the lab conduct multiple …

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Evaluating The Effect Of Competition On Adult Physical Activity Using Heart Rate Monitoring, Julia De Paula Silva Sep 2025

Evaluating The Effect Of Competition On Adult Physical Activity Using Heart Rate Monitoring, Julia De Paula Silva

OneUSF Undergraduate Research Conference

As of 2023 it has been reported that the United States is facing a physical inactivity crisis, with approximately 24.2% of adults meeting the recommended engagement levels of physical activity (PA). A lack of PA engagement is associated with an increased risk of obesity, type 2 diabetes, cardiovascular disease, and types of cancer (e.g., colon, breast). Therefore, the purpose of the proposed study is to develop a cost-effective behavioral intervention to promote PA among adults. This study will recruit dyads of existing friends between ages 18–65 who engage in low levels of PA (i.e., at least 45 min per week). …

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The Impact Of Genistein On Pai-1 Levels And Airway Inflammation In Asthma, Saahil Nayar, Peter Meriga, Mayuresh Behera, Joy Yang Sep 2025

The Impact Of Genistein On Pai-1 Levels And Airway Inflammation In Asthma, Saahil Nayar, Peter Meriga, Mayuresh Behera, Joy Yang

OneUSF Undergraduate Research Conference

Asthma is the fifth leading chronic disorder in the world, affecting hundreds of millions of people yearly. Asthma is a chronic inflammatory disease of the lung airways caused by airway narrowing and remodeling. Plasminogen Activator Inhibitor-1 (PAI-1) has been linked with increased risk of asthma. PAI-1’s production is stimulated by immune cells through the Extracellular signal-Regulated Kinase (ERK) pathway. It inhibits the activity of plasminogen inhibitors, leading to buildup of the extracellular matrix (ECM). ECM buildup leads to airway narrowing, which causes difficulty breathing. Genistein, found in soy, is an isoflavone that has antioxidant and anti-inflammatory properties. This literature review …

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Evaluating Extreme Weather And Climate Adaptation Concerns For Corn And Soybean Farmers, Dharsh Saravana Sep 2025

Evaluating Extreme Weather And Climate Adaptation Concerns For Corn And Soybean Farmers, Dharsh Saravana

OneUSF Undergraduate Research Conference

Corn and soybeans are the most economically valuable crops in Minnesota and represent significant land usage in the state with farmers reporting 14.5 million acres of corn and 7 million acres of soybeans planted in 2024. Continued warming and fluctuations between extreme weather events driven by climate change are expected to increase pest pressure, flood damage, and risk of heat stress for crops and farmworkers. Six climate-conscious commercial corn and soybean farmers located predominantly in southern Minnesota were interviewed to understand their perceived extreme weather and climate impacts, farm management responses to these conditions, and risk management concerns for their …

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The Role Of Body Shape And Size On Burst Swimming Performance In Marine Reef Fishes, Erica A. Molnar Sep 2025

The Role Of Body Shape And Size On Burst Swimming Performance In Marine Reef Fishes, Erica A. Molnar

OneUSF Undergraduate Research Conference

One of the most important behaviors many animals possess is the ability to flee or escape from predators. In fishes, burst swimming is one of the most common strategies during a predation event. With such strong evolutionary pressure, it is noteworthy that reef fishes from the same habitat exhibit such a wide range in body and fin morphology. For the first time, studies focused on fast-start acceleration have been documented in the field, which offers a more realistic and comprehensive look at natural prey escape response to stimuli. With this level of understanding and observation of more realistic escape responses, …

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Harnessing Molecular Docking For Drug Discovery In The Galectin-3 Protein, Attallah Mariam Dean Innis Sep 2025

Harnessing Molecular Docking For Drug Discovery In The Galectin-3 Protein, Attallah Mariam Dean Innis

OneUSF Undergraduate Research Conference

Molecular docking is a fundamental technique in drug discovery, used to predict how a ligand interacts with a target protein or enzyme. This research focuses on the Galectin-3 (G-3) protein, a key factor in excessive scar tissue formation, which is prevalent in pulmonary fibrosis patients. One of the greatest challenges in drug discovery is accurately calculating the binding energy between a potential drug candidate and its target. By constructing drug-protein complexes, binding affinities can be determined using Amber. The selection of the best drug binding affinity corrects the malfunction of the G-3 protein.

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Comparison Between Aunp And Tio2np Nanocarriers For The Treatment Of Chronic Obstructive Pulmonary Disease, Andrew Thomas, Vedant Patel, Rohit Borra, Joy Yang Sep 2025

Comparison Between Aunp And Tio2np Nanocarriers For The Treatment Of Chronic Obstructive Pulmonary Disease, Andrew Thomas, Vedant Patel, Rohit Borra, Joy Yang

OneUSF Undergraduate Research Conference

Chronic Obstructive Pulmonary Disease (COPD) is one of the most fatal diseases in the world, leading to lung tissue damage and persistent inflammation. Patients with COPD are typically treated with a bronchodilator and steroids to alleviate bronchoconstriction and inflammation; however, the steroids have limited effects. Inhaled nanomedicine utilizes small agents that facilitate pulmonary-targeted delivery, which improves the absorption and potency of the medication. Over a century ago, Paul Ehrlich proposed the 'magic bullet' theory—targeting diseases precisely while minimizing side effects. Recently, nanomedicine has emerged to support Ehrlich’s theory by fostering nanoparticle drug delivery systems, such as gold (AuNPs) and titanium …

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Future Critical Habitat For The Roseate Spoonbill In Florida: A Probabilistic Habitat Suitability Model Based On County Population Growth And Existing Spoonbill Sightings, Ria R. Reynolds Sep 2025

Future Critical Habitat For The Roseate Spoonbill In Florida: A Probabilistic Habitat Suitability Model Based On County Population Growth And Existing Spoonbill Sightings, Ria R. Reynolds

OneUSF Undergraduate Research Conference

Historically, studies surrounding future conservation practices for the roseate spoonbill (Platalea ajaja) have been scarce, instead focusing on ecosystem/community based spatial analyses. The roseate spoonbill has long acted as both a flagship species for conservation and ecotourism and an indicator species of wetland health. However, the lack of focus on this species in research only aids in the disjointed classification of their vulnerability levels – the IUCN Red List labeling them as a species of least concern while the Gulf Coast Vulnerability Assessment describes them as highly vulnerable with the lowest capacity to adapt. An individualized assessment of the roseate …

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The United States’ Secret Warfare Against Democracy, Ashtyn J. Smith Sep 2025

The United States’ Secret Warfare Against Democracy, Ashtyn J. Smith

OneUSF Undergraduate Research Conference

This study examines the methods used by the U.S government to orchestrate the overthrow of the democratically elected Guatemalan president Jacobo Árbenz in 1954, by focusing on declassified CIA and State Department documents. Through operation PBSUCCESS, the U.S employed a combination of psychological warfare, economic pressure, diplomatic isolation, and paramilitary operations to destabilize the Árbenz administration. CIA documents reveal the role of propaganda campaigns, assassination proposals, and the arming of opposition forces to create internal chaos. By using primary sources such as CIA memos, and the Foreign Relations of the United States (FRUS) archives, this research will outline the step-by-step …

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Srgap2c And The Human Mind: A Genetic Key To Cognitive Evolution, Alexis J. Zayas Sep 2025

Srgap2c And The Human Mind: A Genetic Key To Cognitive Evolution, Alexis J. Zayas

OneUSF Undergraduate Research Conference

The SLIT-ROBO Rho GTPase Activating Protein 2C (SRGAP2C) gene is a human-specific ortholog of murine SRGAP2 and paralog of SRGAP2A, playing a pivotal role in cortical development and neural plasticity. Unlike SRGAP2A, SRGAP2C arose through segmental duplications unique to the Homo lineage approximately 3.4, 2.1, and 1 million years ago. These duplication events coincide with the divergence of early Homo species from Australopithecus and the emergence of increased cognitive abilities and tool use. SRGAP2C functions as a dominant-negative regulator of SRGAP2A by inhibiting its activity. This results in delayed synaptic maturation and increased density of dendritic spines, key factors thought …

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Real-Time Decisions, Real-Time Results: The Power Of Point-Of-Care Ultrasound (Pocus), Muhamed M. Jaber, Natalie A. Brin, Andrea Marcano-Rodriguez, Ryan Singh, Grace Faberlle Sep 2025

Real-Time Decisions, Real-Time Results: The Power Of Point-Of-Care Ultrasound (Pocus), Muhamed M. Jaber, Natalie A. Brin, Andrea Marcano-Rodriguez, Ryan Singh, Grace Faberlle

OneUSF Undergraduate Research Conference

Point-of-care ultrasound (POCUS) serves as an invaluable tool in the assessment of anatomical variation, the guidance of invasive interventions and the diagnosis of critical conditions which may lead to changes in plan of care. Using POCUS, anesthesiologists may benefit from this fast diagnostic tool. This technology improves speed, success rate and gets patients to surgery faster. The purpose of this pilot program evaluation was to identify the anesthesiologist’s system and processes for clinical decision-making during the perioperative phases of care. A MANOVA was conducted to identify differences across groups. The independent variable was the type of POCUS scan performed [GU, …

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Cardiopulmonary Interactions In Heart Failure And Chronic Lung Disease, Krish Makhija, Rithvik Bhathivi, Riya Narwani, Stuti Dibbur Sep 2025

Cardiopulmonary Interactions In Heart Failure And Chronic Lung Disease, Krish Makhija, Rithvik Bhathivi, Riya Narwani, Stuti Dibbur

OneUSF Undergraduate Research Conference

Globally, cardiovascular diseases, which are directly related to cardiopulmonary interactions, affect over half a billion people and cause 20.5 million deaths in 2021. Cardiopulmonary interactions refer to the complex interactions between the heart and lungs, particularly in diseases where dysfunction in one organ significantly impacts the other. This research aims to discover treatments and prevention methods for Cardiopulmonary Interactions in Heart Failure and Chronic Lung Disease. The aim is to help find early detections of these diseases and educate the public on how to prevent these diseases. A systematic review analyzed 22 peer-reviewed studies out of 45 from 2010 to …

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Stem Cell And Regenerative Therapies For Primary Ciliary Dyskinesia: Restoring Ciliary Function With Ipscderived Airway Cells, Riya Hirani, Sriharshini Vasireddy, Dedeepya Kutha, Stuti Dibbur Sep 2025

Stem Cell And Regenerative Therapies For Primary Ciliary Dyskinesia: Restoring Ciliary Function With Ipscderived Airway Cells, Riya Hirani, Sriharshini Vasireddy, Dedeepya Kutha, Stuti Dibbur

OneUSF Undergraduate Research Conference

Primary Ciliary Dyskinesia (PCD) is a genetic disorder that impairs ciliary function, leading to respiratory and fertility issues. While genetic mutations and stem cell-derived airway cells have been explored, effective regenerative therapies are still lacking. This study examines the potential of iPSCs in restoring ciliary function and advancing PCD treatments. Furthermore, it aims to evaluate the effectiveness of iPSC-derived airway cells in replicating functional cilia for potential regenerative therapies in PCD. Additionally, it seeks to identify genetic targets that may enhance treatment strategies. This study reviews existing literature to examine the role of stem cell-derived airway cells on restoring ciliary …

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Gpcr-Mediated Mechanisms In Obesity: The Role Of Ghrelin And Glp-1 Receptors​, Ryan Singh, Tuana Cenberoglu, Jonathan Budlong, Jaclyn Alejandro, Andrea Weitoschova, Libin Ye Sep 2025

Gpcr-Mediated Mechanisms In Obesity: The Role Of Ghrelin And Glp-1 Receptors​, Ryan Singh, Tuana Cenberoglu, Jonathan Budlong, Jaclyn Alejandro, Andrea Weitoschova, Libin Ye

OneUSF Undergraduate Research Conference

G protein-coupled receptors (GPCRs) regulate metabolism and transmit appetite cues throughout the brain and digestive system. Binding to GPCRs, ghrelin, and GLP-1 are ligands that influence hunger, energy balance, and insulin secretion. Understanding the relationship between GPCRs and ligands such as ghrelin and GLP-1 offers critical insights into treating metabolic disorders such as obesity, a growing issue in America. Our methodology involved a literature review using USF, NIH, and JSTOR databases. Search terms like “GPCR obesity,” “GLP-1 obesity,” and related keywords identified articles from 2000 onward, yielding 59 studies on GLP-1 and ghrelin in obesity. GLP-1 receptor agonists (GLP-1RAs), initially …

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