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Doxycycline-Associated Intracranial Hypertension In The Treatment Of H. Pylori Infection: A Case Report, Kashif Ali, Diana Othon Martinez, Roberto Manllo Karim

Research Colloquium

Doxycycline is a commonly used antibiotic, but rarely, it can induce pseudotumor cerebri (PTC), a condition marked by increased intracranial pressure without a mass lesion. We report a case of a 35-year-old woman with diabetes and stage 4 chronic kidney disease who developed headache and blurry vision two weeks after completing doxycycline for H. pylori. Imaging was unremarkable, but lumbar puncture showed elevated opening pressure (40 cm H₂O) with normal CSF, confirming PTC. The patient improved with acetazolamide and was asymptomatic on follow-up. This case underscores the need for clinicians to consider doxycycline-induced PTC in patients presenting with visual …

Development Of Metal-Organic Framework-Based Formulation For Cancer Therapeutics, Kaitlyn D. Ybanez, Rahul Tiwari, Joel De Los Santos, Tarun Minocha, Bianca Jimenez, Subhash Chauhan, Murali Yallapu

Research Colloquium

Background: Novel hydrogel-based drug delivery systems integrating 𝛾-cyclodextrin metal-organic frameworks (𝛾-CD-MOFs) have recently been developed to overcome the hydrophobicity and poor bioavailability of certain chemotherapeutic drugs. Thermosensitive Pluronic F-127 hydrogels can deliver 𝛾-CD-MOFs to target sites, promoting sustained and regulated drug release, especially for mucosal adhesion scenarios as warranted in cervical cancer. This study presents the development of a formulation that encapsulates curcumin, a model anticancer agent, into a Pluronic F-127 Hydrogel + 𝛾-CD-MOFs to enhance dispersion and enable sitespecific gelation at physiological temperatures (37°C).

Methods: Curcumin-loaded 𝛾-CD-MOFs were synthesized by dissolving 𝛾-CD (1.0 mmol, 1.30 g) and KOH …

Hiv-Related Neuropathic Pain And Ad Comorbidity: Effect Of Pinene, Jose Rios, Mohammed Alnoud, Emmanuel Franco, Justin Mills, Joshua Nwose, Maria Sophia Malbas, Hiram Garcia, Khalid Benamar

Research Colloquium

Background: Chronic pain, especially neuropathic, is the most severe form of chronic pain. People with neuropathic pain often have hyperalgesia, allodynia, and ongoing pain. 53% of American adults living with Human immunodeficiency virus (HIV) are over the age of 50, due mainly to the successful treatment regimens helping HIV-positive adults survive for decades with HIV and reach age-related neurodegenerative diseases such as Alzheimer’s disease (AD). As the population ages, the number of individuals who experience AD and HIV-related neuropathic pain will also increase. Therefore, the comorbidity of these two clinically unmet needs will become an increasingly pressing challenge and …

Role Of Vitamin D In Periodontal Integrity And Cognitive Function Among Older Adults: A Nhanes 2011 Study, John Nicholas Cauba, Noah Al-Hassan, Taha Al-Hassan, Krishi Korrapati, Maria Quiniones, Seratna Guadarrama, Juan Lopez-Alvarenga

Research Colloquium

Background: Periodontal disease, characterized by inflammation and damage to connective tissue due to biofilm accumulation and an inflammatory response, affects 20–50% of the global population. While some studies suggest a link between periodontal disease and cognitive decline, the role of vitamin D in this relationship remains underexplored. Given vitamin D’s involvement in immune modulation, bone remodeling, and possibly cognition, we hypothesize that higher serum 25(OH)D3 levels are associated with reduced periodontal damage and better cognitive performance in older adults.

Methods: We analyzed data from 905 participants (50% female), aged ≥60 years, in the NHANES 2011– 2012 cycle with complete periodontal …

Investigating Environmental And Socioeconomic Contributors To Adult Obesity In The Rio Grande Valley, John Nicholas Cauba, Jihoo Woo, Russell Wiggins, Shizue Mito

Research Colloquium

Background: The Rio Grande Valley (RGV), comprising the four southernmost Texas counties—Hidalgo, Cameron, Starr, and Willacy—is a predominantly Hispanic region along the United States– Mexico border. Recent epidemiological studies indicate that the prevalence of obesity in the RGV substantially exceeds both state and national averages, with profound implications for the region’s overall health burden. For instance, large-scale health surveys estimate that between 45% and 50% of Mexican–American adults in the RGV are classified as obese. Genetic predisposition is estimated to account for approximately 50% of the variance in body mass index (BMI), and environmental and lifestyle factors such as diet, …

Interpreting The Supreme Court: Finding Meaning In The Justices' Personal Experiences, Amy Howe

Florida Law Review

At his 2004 confirmation hearing, Chief Justice John G. Roberts Jr. famously compared the role of a Supreme Court Justice to that of a baseball umpire and promised “to remember that it’s my job to call balls and strikes.” Roberts likely intended this to mean that he would serve as a neutral arbiter of the law, who simply applies the existing rules to reach the correct outcome. But in judging, as in baseball, that is not as easy as it sounds, especially when one of the primary criteria on which the Court relies to choose its cases is whether the …

Agenda (Pdf), Lsu Health Sciences Center - New Orleans

Usher Syndrome in Louisiana

Agenda, promotional flyer and resources list for the Usher Syndrome in Louisiana 5th Symposium held September 19, 2025.

Comprehensive Review Of In Vitro Gut-Brain Axis Models In Parkinson’S Disease Research, John Nicholas Cauba, Jihoo Woo, Russell Wiggins, Shizue Mito

Research Colloquium

Background: The pathophysiology of Parkinson's Disease (PD) can be attributed to a gradually progressive dopaminergic neuron (DN) degeneration and aggregation of abnormal α-synuclein in the basal ganglia. While the classic paradigm of PD focuses on the role of neurotransmitter imbalance and motor impairments, there has been increasing scientific interest in the link between the intricate connection between gut dysbiosis with synucleinopathies and PD. This review explores the relevance of the Braak hypothesis, short-chain fatty acids (SCFAs) in neuronal viability, and gastrointestinal barrier dysfunction through the lens of in vitro modeling.

Methods: A collection of prospective literature was conducted …

Playful Learning Journeys: Exploring The Perceptions And Knowledge Of Lecturers/Tutors And Student Teachers, Frank Twum, Samuel Kweku Hayford, Dandy Dampson, Johnnie Kojo Hayford

Journal of Educational Research and Practice

This paper investigated the perceptions and knowledge of play-based learning (PBL) by lecturers/tutors and student teachers. Ninety lecturers/tutors (68 males, 22 females) and 363 student teachers (191 males, 172 females) participated in the study. While both lecturers/tutors and student teachers favored PBL, they had some concerns. Lecturers/tutors acknowledged the benefits of PBL, including its enhancement of memory, conceptual development, and motor skills in children. However, nearly two-thirds found it time-consuming. Student teachers were of the view PBL promoted positive student experiences. However, more than half felt PBL offered limited opportunities for their own learning during lessons. Both groups demonstrated knowledge …

Teacher Perceptions Of The Mental Health And Socio-Emotional Challenges Of English Language Learners, Nilufer Guler, Dincer Guler, Kyle Bush

Journal of Educational Research and Practice

A fast-growing percentage of students in K–12 classrooms are English language learner (ELL) students, and a large number of these students are experiencing a vast array of academic and non-academic challenges at school. Many ELL challenges involve inadequate socio-emotional learning (SEL) skill development, as well as mental health obstacles, and many schools are not equipped with the resources needed to address and resolve these challenges for ELLs.

In this study, we focus on teacher observations of the SEL and mental health challenges that K–12 students face. In the initial survey, 120 teachers participated regarding ELLs and these challenges. Following the …

Semax For Parkinson’S Neuroprotection: A Qualitative Review Of Preclinical Evidence, Jefferson Tait, Mohammad Yaman Karkoutly, David Rakay, Edurado Aquino

Research Colloquium

Background: The use of peptides as an alternative treatment for neurological disease is an emerging practice that has had tremendous success. Semax, a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH 4–10), is well known and used clinically in Russia and Eastern Europe for ischemic stroke therapy. Moreover, Semax has also been reported to modulate monoaminergic systems. Because Parkinson’s disease (PD) involves the loss of dopaminergic neurons, Semax’s neuromodulatory properties make it a potential candidate for the treatment of Parkinson's. Here, we hope to evaluate whether Semax could be an alternative therapy for PD by reviewing evidence on its effects on …

Wernicke’S Encephalopathy With Classic Triad And Normal Mri In A Young Woman Following Rapid-Sequence Bariatric And Biliary Surgery, Hugo Zamarron, Nina Mourao, Roberto A. Cruz Saldana

Research Colloquium

Background: Wernicke’s encephalopathy is a life-threatening neurological disorder caused by thiamine deficiency, most commonly associated with alcoholism. However, postoperative nutritional deficiencies in young patients undergoing bariatric procedures are increasingly recognized. This case is unique due to the rapid succession of bariatric and cholecystectomy surgeries, development of classic Wernicke’s symptoms with a normal MRI, and diagnostic delay due to overlapping differential diagnoses including intracranial hypotension and myelopathy.

Case Presentation: A 22-year-old woman with class III obesity underwent sleeve gastrectomy in July 2022, followed by significant weight loss and persistent intractable vomiting. Due to suspected gallbladder disease, she underwent a cholecystectomy in …

Corticobasal Syndrome With Mixed Pathology In The Absence Of Grn Mutation: A Clinico-Pathological Case Of Ftld-Tdp With Coexisting Alzheimer’S And Lewy Body Pathology, Hugo Zamarron, David Irwin, Jeffery Phillips, Edward Lee, Matthew Tisdall, Corey Mcmillan

Research Colloquium

Background: Corticobasal syndrome (CBS) is a neurodegenerative disorder characterized by often asymmetric fronto-pariteal and extra-pyramidal features that is traditionally associated with tauopathy, but pathological findings are heterogenous, including other forms of frontotemporal lobar degeneration (FTLD) and mixed pathologies of aging. We present clinical, radiographic, and histopathologic features of asymmetry in a unique patient with CBS and underlying FTLD with TDP-43 pathology (FTLD-TDP), co-occurring with other age-related pathologies.

Case Presentation: A 76-year-old man presented with progressive cognitive and motor dysfunction including asymmetric parkinsonism, left-sided dystonia and rigidity, apraxia, visuospatial impairment, and a subtle social disorder including apathy and social withdrawal. The …

Bilateral Small Vessel Strokes In A Young Male With Coccidioidal Meningitis And Suspected Cns Vasculitis, Hugo Zamarron, Ahsan Ali

Research Colloquium

Background: Cerebral small vessel strokes in young, otherwise healthy adults without traditional vascular risk factors are rare and warrant further investigation. Central nervous system (CNS) vasculitis is an uncommon etiology that may be triggered by infections, including fungal pathogens. This case is notable for a suspected primary CNS vasculitis manifesting as bilateral deep infarcts in the setting of Coccidioidal meningitis. It highlights the importance of considering fungal infections and vasculitis in the differential diagnosis of stroke in younger patients.

Case Presentation: A 32-year-old previously healthy male presented with fever, headache, and was diagnosed with aseptic meningitis. He was later readmitted …

Aspiration Pneumonitis Mimicking Pneumonia: Diagnostic Reassessment And Antibiotic Stewardship In A Case Of Cerebral Palsy-Associated Dysphagia, Hernan Guanajuato, Jose Campo Maldonado

Research Colloquium

Background: Aspiration pneumonitis, an acute chemical lung injury following the inhalation of gastric contents, is frequently misdiagnosed as bacterial pneumonia. Misclassification often leads to unnecessary antibiotic use. Early recognition and accurate diagnosis are critical to avoid overtreatment and associated risks.

Case Presentation: A 21-year-old male with a history of cerebral palsy with quadriplegia, epilepsy, oropharyngeal dysphagia (status post PEG tube), and bedbound status presented to the ED following a witnessed aspiration event. During oral pleasure feeding, he choked, became transiently cyanotic, and had a brief coughing episode after vomiting. Family also reported a one-week history of intermittent cough, subjective …

Comparative Evaluation Of Indirect Sinus Lift Using Cmc Technique Versus Direct Sinus Lift Via Lateral Window Technique In Subantral Type Iv, Dhurgham Hasan Hassan Alkaabi, Sabah Abdulrsul Hamoodi Alheeti, Faaiz Yaqub Al-Hamadani

Maaen Journal for Medical Sciences

Background: Maxillary sinus augmentation is a common implant placement procedure when residual bone height (RBH) in the posterior maxilla is limited, especially in subantral type IV cases. A less invasive alternative to the traditional lateral window procedure is the crestal approach using the CMC (Crestal approach with membrane Control) technology. Objective: To evaluate the differences between the CMC technique and the conventional lateral window approach in terms of clinical performance, bone density results, surgical time, and complication rates for sinus lifting in subantral type IV cases. Methods: Twenty patients with posterior maxillary edentulism and RBH < 5 mm were divided into two groups at random: Group A (n = 10) received direct sinus lift using the lateral window approach, and Group B (n = 10) received indirect sinus lift using the CMC technique. Four sites (crestal, apical, buccal, and palatal) in Hounsfield Units (HU) were evaluated for bone density using CBCT scans both before and four months after surgery. A “visual analog scale” was used to quantify patient discomfort, postoperative problems, and surgery time. Results: Both methods proved highly …

Total Synthesis Of The Marine Cytotoxic Mansouramycin And Derivatives, Aditya Dantu, Gabriella L. Madrigal, Neel Gondi, David Osazee, Ahmad Amro, Whard Alsabbagh, Shizue Mito

Research Colloquium

Purpose: Isoquinolinequinones are a group of organic compounds which are composed of an isoquinoline fused to a quinone ring. This class of molecules is known to exhibit a wide variety of biological activities, including cytotoxic and antitumor properties. Among the many families of isoquinolinequinones are the Caulibugulones and Mansouramycins, which exhibit anticancer properties and are thus desirable subjects for cancer-related research. They are obtained by isolation from marine bryozoan Caulibugula intermis and marine Streptomyces sp respectively, however these compounds are difficult to extract. Thus, organic synthesis is being explored as a method of obtaining them; this project focuses on the …

Characterization And Purification Of Muc13 Monoclonal Antibodies: Techniques And Applications, Shabnam Malik, Daniel Zubieta, Mohammed Sikander, Sheema Khan, Murali Yallapu, Meena Jaggi, Subhash Chauhan

Research Colloquium

Background: MUC13 is a transmembrane glycoprotein that is critically involved in the progression of various cancers, including liver, pancreatic, colon, and ovarian cancers. Despite the recognition of its presence and significance in these malignancies, the development of specific antibodies targeting MUC13 remains limited. This study aims to produce a monoclonal antibody against MUC13 and evaluate its effectiveness in assessing differential expression related to cancer progression.

Methodology: We utilized hybridoma technology to generate specific monoclonal antibodies targeting MUC13. Mouse splenocytes were immunized with recombinant MUC13 protein and subsequently fused with myeloma cells to create hybridomas. Positive clones were selected through ELISA …

Investigating Cucurbitacin D'S Efficacy In Ameliorating Benzo[A]Pyrene-Induced Hepatic Injury, Mohammed Sikander, Shabnam Malik, Daniel Zubieta, Anyssa Rodriguez, Fathi T. Halaweish, Murali Yallapu, Meena Jaggi, Subhash Chauhan

Research Colloquium

Hepatocellular carcinoma (HCC) is increasingly linked to various co-morbidity factors, notably smoking, which introduces benzo[a]pyrene—a potent carcinogen known for its role in liver damage. Cucurbitacin, a triterpene with diverse biological activities, exhibits antioxidant, antiinflammatory, and anti-cancer properties, yet its hepatoprotective effects remain inadequately explored. In this study, we investigated the hepatoprotective activity of cucurbitacin D, a novel analog, against benzo[a]pyrene-induced liver injury in human HepG2 cells. To evaluate its protective effects, we conducted proliferation, clonogenicity, migration, invasion assays, alongside Western blotting and qPCR analyses. The DCFDA assay was employed to measure intracellular reactive oxygen species (ROS) levels in liver cells. …

Investigating Soil Co2 Flux Among Varying Soil Types During Inundation Conditions, Jennifer Volk, Arya Patel

The Pegasus Review: UCF Undergraduate Research Journal

Land use change has contributed to the increase of carbon dioxide (CO₂) release, exacerbating global greenhouse gas (GHG) emissions. CO₂ is also naturally produced in the soil via microbial respiration which breaks down soil organic matter (SOM). Several studies have investigated factors affecting CO₂ flux from soils, but few have compared CO₂ flux from a range of soil types under controlled conditions with varying water levels. This study subjected intact soil cores from six different soil types to varied periods of inundation and dry events using the same water and timing. During each event, CO …

Disruption Of Β-Catenin Signaling As A Strategy To Suppress Emt In Cervical Cancer, Mohammed Sikander, Shabnam Malik, Sonam Kumari, John Apraku, Theresa M. Biju, Fathi T. Halaweish, Murali Yallapu, Meena Jaggi, Subhash Chauhan

Research Colloquium

Cervical cancer (CxC) is a leading cause of mortality and morbidity among women worldwide. Current chemotherapeutic agents for CxC have shown systemic toxicity in CxC patients. Ormeloxifene (ORM) is a non-toxic and non-steroidal drug with well-defined pharmacokinetic and pharmacodynamic properties in humans. In this study, we introduce a new analogue of ormeloxifene, Bromo-ormeloxifene (Br-ORM), which demonstrates enhanced therapeutic efficacy against CxC in both in vitro and in vivo models. We investigated Br-ORM's effects on CxC cell growth through colony formation and MTS assays, alongside molecular docking studies with βcatenin using AutoDock4. Furthermore, we analyzed the influence of Br-ORM on the …

An Unusual Case Of Spontaneous Bacterial Peritonitis Due To Weissella Cibaria In A Patient With Decompensated Cirrhosis, Janetly Reinoso, Felipe Diaz Jr, Jose E. Campo Maldonado

Research Colloquium

Background: Spontaneous bacterial peritonitis (SBP) is a serious infection commonly encountered in patients with decompensated cirrhosis and ascites, usually involving gram-negative organisms. Weissella cibaria is a gram-positive, catalase-negative, facultative anaerobe not typically associated with intra-abdominal infections. This case report highlights an unusual instance of SBP caused by W. cibaria in a cirrhotic patient, emphasizing the clinical importance of identifying atypical organisms and discussing implications for antimicrobial stewardship in vulnerable populations.

Case Presentation: A 65-year-old woman with decompensated nonalcoholic steatohepatitis (NASH) cirrhosis status post-transjugular intrahepatic portosystemic shunt (TIPS) placement and recurrent ascites requiring weekly paracentesis presented with altered mental status following …

From Imaging To Impact: A Multi-Disciplinary T32 Program Framework And Initial Insights For Training In Image-Guided Cancer Therapy, Kari J. Brewer Savannah, Stephen Y. Lai, Clifton D. Fuller, Kristy K. Brock

Advances in Cancer Education and Quality Improvement

As multi-disciplinary image-guided assessment and therapies become increasingly important for precision oncology, the need for comprehensive training opportunities that effectively prepare the next generation of clinician-scientists and scientists is evident. We present an innovative, evidence-based research training framework that integrates the following critical features: 1) intentional and personalized mentoring and career development, 2) immersive research in image-guided cancer therapy, 3) strategic mentored clinical exposure, 4) structured didactic learning and professional development opportunities, and 5) mentored grant writing. Designed to foster scientific rigor, translational thinking, and multi-disciplinary collaboration, the Image-Guided Cancer Therapy T32 Training Program (IGCT-T32) aims to prepare postdoctoral fellows …

Imam Muhammad Bin Abdullah Al-Nufayli (D. 234 Ah) And His Statements On The Narrators, Both In Terms Of Criticism And Validation (A Comparative Critical Study), Farhan Bin Khalaf Bin Farhan Al Anazi

UB Journal for Humanities

Research topic: Imam Muhammad bin Abdullah Al-Nufayli and His Statements on the Narrators, Both In Terms of Criticism and Validation (A Comparative Critical Study). It aims to: introduce him, clarify his position among the leading scholars of hadith criticism, collect his statements on narrators and compare them with those of the other leading scholars, and explain his approach in terms of strictness, leniency, and moderation. The researcher followed an inductive, analytical, and critical approach. The research included the concept of criticism and validation (jarḥ wa ta’dīl), a biography of Imam Muhammad bin Abdullah Al-Nufayli, and a comparison of his statements …

The Role Of Metaphorical Imagery And Textual Gaps In Constructing National Meanings In The Poem “A Nation That Does Not Fade” By Issa Jaraba: An Analytical Study, Mohsena Abdullah Habib Al-Harthi

UB Journal for Humanities

This study aims to examine the poem “A Homeland That Never Fades” by the poet Issa Jarraba through the analysis of two key rhetorical mechanisms: metaphorical imagery and textual ellipsis, represented by the use of the ellipsis mark. The analysis seeks to answer the central question: How does Issa Jarraba employ metaphorical imagery and textual ellipsis in his poem “A Homeland That Never Fades” to construct national meanings and deepen their emotional impact? The study focuses on analyzing the manifestations of metaphorical imagery, while also addressing textual ellipsis as a rhetorical device that offers the reader space for reflection and …

Default Bogon Routes Blocking In Bgp, N/A

Defensive Publications Series

The technology described in this publication relates to a mechanism to reduce internet outages caused by the accidental propagation of bogon routes. The approach enhances Border Gateway Protocol (BGP) implementations to block bogon IPv4 and IPv6 routes by default on external BGP sessions with public Autonomous System Numbers (ASNs). Resource Public Key Infrastructure (RPKI) does not prevent bogon routes and current mitigation relies on operator-managed routing policies. The technology described herein introduces a standardized blocking mechanism built directly into BGP. Internet Service Providers (ISPs) retain flexibility through a configurable override mechanism, referred to as a “bogon knob,” within their BGP …

Antiplatelet Effects Of Angelica Dahurica Root Extract Without Gastric Lesion Formation In Rats, Pitiphat Srisom, Kasem Rattanapinyopituk, Uthai Sotanaphun, Rataya Luechapudiporn

The Thai Journal of Pharmaceutical Sciences

Background: Platelet aggregation plays a crucial role in hemostasis; however, excessive platelet activation can lead to thrombus formation, contributing to cardiovascular diseases. While aspirin (acetylsalicylic acid [ASA]) is commonly used as an antiplatelet agent, its longterm use is associated with gastrointestinal side effects. Angelica dahurica (AD), a traditional herbal remedy, has shown in vitro antiplatelet activity and cyclooxygenase enzyme inhibition. However, its in vivo effects on platelet aggregation and gastric safety remain unclear.

Objectives: This study aimed to investigate whether Angelica dahurica root extract (ADE) could inhibit platelet aggregation and prevent aspirin-induced gastric lesions.

Materials and Methods: AD was extracted …

Bone-Sparing Effects Of Pueraria Mirifica Extract On Bone Loss In Androgen-Deficient Cynomolgus Macaques (Macaca Fascicularis), Thaweechai Saetae, Taratorn Kemthong, Sukanya Jaroenporn, Suchinda Malaivijitnond

The Thai Journal of Pharmaceutical Sciences

Background: Synthetic estrogens provide remarkable benefits for bone health in men; however, they also present several drawbacks after long-term use. Pueraria mirifica, a phytoestrogen-rich herb, has garnered attention due to its positive effects and minimal adverse side effects on bone in females. Most research on bone health has been conducted on rodents; however, bone architecture and remodeling in rodents differ from those in humans, making it challenging to apply the results to clinical trials.
Objectives: Thus, this study assessed the bonesparing effects of P. mirifica extract (PME) in androgen-deficient male cynomolgus macaques.

Materials and Methods: Adult male macaques were divided …

Quality By Design Approach To Method Development And Validation For Quantitative Estimation Of Dapagliflozin And Linagliptin In Pharmaceutical Tablet Dosage Forms, Prechha Shrestha, Ashwinee Kumar Shrestha, Rajan Shrestha, Barsha Thapa

The Thai Journal of Pharmaceutical Sciences

Objectives: The present study utilizes a quality by design approach to develop a simple, robust, and stability-indicating high-performance liquid chromatography method for quantifying dapagliflozin (DAPA) and linagliptin (LINA) in a fixed-dose combination and validate it according to the ICH-Q2 (R1) guidelines.

Materials and Methods: The effect of critical method parameters (CMPs), namely percentage of acetonitrile (ACN), pH of the buffer, and flow rate, on critical quality attributes (CQAs) such as retention time, area, tailing factor, and theoretical plates was studied using Box–Behnken design (BBD). Response optimizer was utilized to optimize the experimental conditions. The mobile phase (MP) consisted of ACN …

Cytotoxic And Anti-Inflammatory Activities Of Extracts Of Pra-Sa-Ka-Phrao Remedy And Its Plant Components, Theeraphong Ninlaor, Arunporn Itharat, Srisopa Ruangnoo, Pakakrong Thongdeeying, Sunita Makchuchit, Pranporn Kuropakornpong, Settakul Boonyasakseree, Chadchom Choockong, Ninnart Intharit, Neal M. Davies

The Thai Journal of Pharmaceutical Sciences

Background: Pra-Sa-Ka-Phrao (PSKP) is a traditional Thai remedy recognized in the National List of Essential Herbal Medicines of Thailand. It is traditionally used for treating flatulence and colic pain. It consists of eight components derived from plants with Ocimum tenuiflorum leaves as a main ingredient. However, there are no reports regarding the biological activities and chemical composition of PSKP.

Objectives: This study aimed to investigate cytotoxic activities, using cell lines related to the gastrointestinal (GI) system, and anti-inflammatory activities, along with chemical composition, of the PSKP complete formula (PSKPC) and a modified incomplete formula (PSKPIC).

Materials and Methods: Two extraction …