Digital Commons Network^™

Late Morbidity And Mortality In Survivors Of Childhood Ependymoma: A Report From The Childhood Cancer Survivor Study (Ccss), Katharine R Lange, Peter De Blank, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Joseph Neglia, Paul C Nathan, Rebecca Howell, Kirsten K Ness, Lucie M Turcotte, Wendy Leisenring, Gregory T Armstrong, Tara Brinkman, Daniel C Bowers, Mehmet Fatih Okcu

Faculty, Staff and Student Publications

Background/objectives: Treatment of childhood ependymoma evolved from 1970 to 1999 by reducing radiation volumes and incorporating chemotherapy. The impact of these changes on long-term health outcomes remains unknown. In this report, we evaluated temporal changes in all-cause and cause-specific late mortality, chronic health conditions (CHCs), and subsequent neoplasms (SNs) in the Childhood Cancer Survivor Study (CCSS) cohort of adult survivors of pediatric ependymoma, diagnosed between 1970 and 1999.

Methods: A total of 404 five-year survivors of ependymoma (47.5% female, 80.7% non-Hispanic White, median 6 (range 0-20) years at diagnosis, 22 (5-49) years from diagnosis) diagnosed between 1970 and 1999 and …

In Vitro And In Vivo Evaluation Of Autochthonous Probiotics And Their Effects On The Mucosal Health Of Nile Tilapia (Oreochromis Niloticus), Sherilyn T. Abarra, Sahya Maulu, Sheu G. Odu-Onikosi, Taofik A. Momoh, Benjamin Eynon, Matthew Emery, Mark Rawling, Daniel L. Merrifield

School of Biological and Marine Sciences

The host microbiome is a promising source of probiotics for aquaculture species including Nile tilapia. In this study, the probiotic potential of autochthonous bacterial isolates from Nile tilapia and carp mid-intestines were screened in vitro. Two isolates (C61 and T70), closely related to Bacillus subtilis, exhibited antagonistic activity against multiple pathogen species and demonstrated multiple digestive enzyme activities. Their antagonistic activity in Aeromonas hydrophila assays remained even under simulated intestinal juice (SIJ) exposure. Subsequently, C61 (PT1) and T70 (PT2) were added to experimental diets at log 7 CFU/g of diet, and fed to Nile tilapia (5.32 ± 0.12 g) for …

Advancements In Understanding Spasticity: A Neuromusculoskeletal Modeling Perspective, Mohammad S Shourijeh, Argyrios Stampas, Shuo-Hsiu Chang, Radha Korupolu, Gerard E Francisco

Faculty, Staff and Student Publications

Spasticity, a complex consequence of upper motor neuron lesions, poses challenges for clinical assessment due to its neural and mechanical origins. Traditional scales like the Modified Ashworth and Tardieu Scales provide subjective, context-limited insights, often missing spasticity's dynamic nature. Neuromusculoskeletal (NMS) modeling offers objective, quantitative insights by integrating patient-specific muscle-tendon properties, reflex dynamics, and multi-joint biomechanics. This scoping review examines advancements in spasticity modeling, comparing mechanical, neurological, and integrated approaches, and their applications in conditions like cerebral palsy and stroke. We highlight barriers to clinical translation, including computational demands and regulatory challenges, and propose future directions, such as real-time simulation …

Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

Pexidartinib (PEX, TURALIO®), a tyrosine kinase inhibitor, is approved for treating tenosynovial giant cell tumor in adults. However, its potential to cause fatal liver injury has prompted the U.S. FDA to issue a black box warning, and the mechanisms underlying its hepatotoxicity remain largely unknown. As biotransformation may contribute to PEX-induced hepatotoxicity, understanding its metabolism is essential. Our previous research indicated that PEX forms reactive metabolites in human and mouse liver microsomes and in human hepatocytes. We investigated PEX metabolism and liver distribution in mice with a focus on metabolite characterization. Our data shows that PEX is mainly excreted into …

Image-Based Meta- And Mega-Analysis (Ibmma): A Unified Framework For Large-Scale, Multi-Site, Neuroimaging Data Analysis, Ahmed Hussain, Courtney Russell, Benjamin Suarez-Jimenez, Elena Pozzi, Hadis Jameei, Lianne Schmaal, Ilya M Veer, Lea Waller, Neda Jahanshad, Sophia I Thomopoulos, Lauren E Salminen, Miranda Olff, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam Van Zuiden, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Yuval Neria, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Jennifer S Stevens, Kerry Ressler, Tanja Jovanovic, Sanne J H Van Rooij, Negar Fani, Sven C Mueller, Anna R Hudson, Judith K Daniels, Anika Sierk, Antje Manthey, Henrik Walter, Nic J A Van Der Wee, Steven J A Van Der Werff, Robert R J M Vermeiren, Christian Schmahl, Julia I Herzog, Ivan Rektor, Pavel Říha, Milissa L Kaufman, Lauren A M Lebois, Justin T Baker, Isabelle M Rosso, Elizabeth A Olson, Anthony King, Israel Liberzon, Michael Angstadt, Nicholas D Davenport, Seth G Disner, Scott R Sponheim, Thomas Straube, David Hofmann, Guangming Lu, Rongfeng Qi, Xin Wang, Austin Kunch, Hong Xie, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven E Bruce, Josh Cisler, Marisa Ross, Ryan J Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine Larson, Terri A Deroon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jeremy Elman, Matthew Panizzon, Carol E Franz, Michael J Lyons, William S Kremen, Brandee Feola, Jennifer U Blackford, Bunmi O Olatunji, Geoffrey May, Steven M Nelson, Evan M Gordon, Chadi G Abdallah, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W J Neufeld, Paul M Thompson, Delin Sun

Faculty, Staff and Students Publications

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully …

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

2020-Current year OA Pubs

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

Short- And Mid-Term Outcomes Of The Extravascular Implantable Cardioverter-Defibrillator In Pediatric And Adolescent Patients: A Single-Center Experience., Nikola Dragisic, Emily R. Backes, Lindsey Malloy-Walton, Edo Bedzra, William Gibson, Philip M. Chang

Manuscripts, Articles, Book Chapters and Other Papers

Experience with the Aurora extravascular (EV) implantable cardioverter-defibrillator (ICD) (Medtronic, Minneapolis, MN, USA) remains limited among pediatric centers in contrast to its broader implantation in adults. We evaluated our single-center experience with the EV ICD as part of our standard ICD options for treatment of malignant ventricular arrhythmias in pediatric subjects. Following approval for EV ICD implantation at our center, five consecutive adolescent patients underwent implantation over a 7-month period. Patient characteristics, qualification for EV ICD placement, nuances in EV ICD implantation in each patient, and post-implant follow-up were reviewed. A total of six out of eight consecutive ICD candidates …

Evaluation Of The Impact Of Coriander Sativum Extract On The Modulation Of Inflammatory And Oxidative Enzymes In Ptz Induced Epilepsy In A Rat Model, Rusul Ali Kadhim, Zahraa Saleem Manji

Maaen Journal for Medical Sciences

Background

Recurrent and spontaneous seizures are a symptom of the epilepsy. It affects up to 65 million individuals globally, with lower-income nations accounting for 80% of cases. Since medicinal plants have special therapeutic qualities, they are frequently used to manage and cure epilepsy and convulsions. Because they have fewer side effects and stronger therapeutic results, medicinal plants are becoming more and more popular worldwide as a result of increased research and clinical use. The pharmaceutical industry is now concentrating heavily on the creation of novel plant-based antiepileptic/anticonvulsant drugs

Aims of the study:

Study the role of coriander sativum extraction in …

Torts And Pesticide Drift: Amending Right-To-Farm Acts In The Wake Of Widespread Dicamba Drift By Nicholas Brown** And Matt Roessing*

Journal of Legal Studies in Business

When crops die in a field prior to harvest, a farmer loses a portion of his salary for that year. When the cause of the crop loss is natural, farmers can usually seek compensation through crop insurance and government commodity support programs. When the crops were lost as a result of pesticide drift, these forms of compensation are not usually available to farmers.1 In order to make up for their losses, farmers can seek damages through judicial redress. For many decades, various state and federal laws have combined to complicate and at times prevent farmers adversely affected by pesticide drift …

Cover Page & Table Of Contents - Volume 23

Journal of Legal Studies in Business

JLSB vol. 23 Title Page & Table of Contents

Latine Doctoral Student Experiences In U.S. Counselor Education And Supervision Programs, Nayara Aparecida Da Costa Silva Beall, Lizbeth Duran Oden, Isabel C. Farrell, Mariaimeé Gonzalez, Stephanie Thorson-Olesen

Journal of Counselor Preparation and Supervision

This study explored the experiences of Latine doctoral students in Counselor Education and Supervision programs in the United States. The consensual qualitative research yielded five domains: cultural values, representation, racialized experiences, support, and social justice. The findings are discussed with direct applications for programs and recommendations for future research.

Evaluating Competencies In Counseling Students: Comparing Adjunct And Core Faculty Ratings, Mark D. Newmeyer, Kaitlyn C. Stafford, Peter J. Buckingham, Karen E. Fischer, Meredith D. Mcdaniel, Rhys P. Wilson

Journal of Counselor Preparation and Supervision

This study examines the differences in how adjunct and core faculty evaluate counseling students using a brief version of the Counselor Competencies Scale-Revised (CCS-R). Data from 647 evaluations of 433 students were analyzed. The results show that adjunct faculty, particularly those with master's degrees, tend to rate students significantly higher on professional counseling dispositions than core faculty, raising concerns about the consistency of gatekeeping in counselor training programs. These findings suggest a need for the standardization of counseling disposition evaluation practices to maintain high training standards. Implications for student-to-faculty ratio requirements are discussed.

Counselor Education: Digital Delivery With Confidence, Nicole Marie Arcuri-Sanders, Alisha Davis

Journal of Counselor Preparation and Supervision

Counselor education programs are required to demonstrate a clear framework, effective implementation, and overall program effectiveness. The pandemic’s surge in online instruction influenced CACREP’s (2024) digital delivery (DD) standards, addressing ethical and legal implications alongside student outcomes. Guidance from digital health initiatives, telemental health ethics and legal practices can be invaluable in clarifying DD protocols for counselor education programs. Understanding the parallels between DD and digital health regulations (e.g., HIPAA, ACA [2014], and NBCC [2023] ethical codes) provides a solid foundation for protecting both students and programs. Integrating technology and modeling digital health practices can enhance counselor education, benefiting both …

Training School Counselors In Anti-Racist Practices, Yenitza Z. Guzman, Tj Schoonover, Christy Tran

Journal of Counselor Preparation and Supervision

This study examines the lived experiences of school counselors-in-training and their development as anti-racist school counselors. Using a qualitative phenomenological approach, we conducted in-depth interviews with 17 school counselors-in-training with a focus on their development and training as anti-racist practitioners. The findings of the study included four themes: (a) education, (b) experiential learning, (c) suggestions for improvement, and (d) cultural competency. This article indicates implications for school counselor educators and school counselors-in-training.

A Holographic Approach: Counseling Skill Development At The Doctoral Level, Kelly Coker, Kristi Cannon, Robyn T. Simmons, Anjuli Corzine

Journal of Counselor Preparation and Supervision

This study examines the perceptions and attitudes of a six-person focus group of counselor educators about teaching advanced counseling skills in CACREP accredited Counselor Education and Supervision doctoral programs. Results of the framework analysis indicate that while counseling skills are valued at the doctoral level, there is a need for individualized and collaborative construction of both assessments for and activities within doctoral internships in counseling. A Holographic Model of Doctoral Skills Training is introduced, providing a comprehensive framework for enhancing doctoral-level counseling skills training in counselor education and supervision programs.

Practicing With Avatars: Exploring Mixed Reality Simulation To Develop Msjccs, Amy L. Cook, Lillian Day, Kristin M. Murphy, Taylor Healy, Julia Kausel, Lindsay M. Fallon, Christopher B. Denning

Journal of Counselor Preparation and Supervision

This study used qualitative content analysis (QCA) to explore perceptions of engaging in Mixed Reality Simulation (MRS) with avatars on the development of Multicultural and Social Justice Counseling Competencies (MSJCCs) for school counselors in training. Results suggested that MRS contributed to improving participants’ confidence in MSJCCs, and they would have valued additional practice with MRS to address implicit bias with clients. Results indicate the need for additional MRS research to advance the development of MSJCCs in school counselor training.

Mental Health Concerns Counselors Should Be Aware Of When Working With Women Experiencing Infertility, Corrina Harris, Kellie Forziat-Pytel

Journal of Counselor Preparation and Supervision

Women experiencing infertility (WEI) are a unique group that rarely receives acknowledgment in the literature as such. These women encounter physical, emotional, and financial burdens throughout their infertility journey. Counseling research is limited on information addressing the experiences of WEI. This article highlights this unique group by providing an overview of the infertility journey for women. Counselors will learn the common mental health concerns to be aware of when working with WEI and examine a case example of infertility with a counselor’s approach. In addition, the article will identify the research gaps related to this population. Implications are made for …

Life Balance For Counselors-In-Training: An Interpretative Phenomenological Investigation, Corey Olver

Journal of Counselor Preparation and Supervision

Life balance is an important yet understudied construct for counselors-in-training (CITs). Pursuing a graduate degree in counseling involves an investment of time and resources that may increase stress and adversely affect CIT wellbeing. This study explores the experience of ten CITs as they navigated life balance during their education. Analysis revealed that life balance was challenging as CITs managed their educational, personal, and work demands. Key findings reveal that satisfaction with life balance is related to alignment between real and ideal activity engagement, that students made important sacrifices to maintain balance, and their educational experience contributed to life balance perception. …

Incorporating Tax Law Into Legal And Regulatory Environment Of Business Courses

Journal of Legal Studies in Business

No abstract provided.

Too Much, Too Little, Or Just Right? Beyond The Perception (Or Reality) Of Law School Rigor In Teaching Undergraduate Copyright Law

Journal of Legal Studies in Business

No abstract provided.

In Vivo Pharmacokinetic Evaluation Of A Gastro-Retentive Triple Drug Delivery System Utilizing Natural Polymers For Enhanced Helicobacter Pylori Eradication, Edukulla Satheesh Kumar, Hindustan Abdul Ahad, Thirumalesh Naik Sugali Banoth

Bulletin of Faculty of Pharmacy Cairo University

This study evaluates the in vivo pharmacokinetics of triple-drug gastro-retentive formulation (metronidazole- Plantago ovata seed mucilage/ clarithromycin- Abelmoschus esculentus fruit mucilage/enteric-coated pantoprazole) for Helicobacter pylori eradication, with a focus on pharmacokinetic parameters (e.g., relative bioavailability vs. conventional doses) as the true contribution. In a cross over study using six rabbits, plasma concentrations of metronidazole, clarithromycin, and pantoprazole sodium were measured via High Performance Liquid Chromatography technique, and pharmacokinetic parameters were determined. A single dose of the optimized formulation (C-8) produced optimal drug levels, with a mean Cmax of 24.36 ± 0.84 μg/mL and tmax at 6 hours. The other pharmacokinetic …

Global Seafarer Shortage In The Age Of Automation “A Cross National Analysis Of Maritime Workforce Gaps, Met System Performance, And Digital Readiness”, Zouheir Abd Elfattah Badawy

Blue Economy

The maritime transport sector is confronting an intensifying shortage of qualified seafarers, particularly licensed officers, which poses substantial threats to global logistics and shipping sustainability. This study conducts a comparative analysis of four key seafarer supplying nations the Philippines, India, China, and the United Kingdom to identify root causes of this workforce crisis in the context of technological change and automation. Utilizing a mixedmethods design, the study integrates statistical workforce data from BIMCO, ICS, and national maritime bodies with survey responses from 428 cadets and junior officers enrolled in accredited MET institutions. The findings reveal that although India and the …

Global Citizenship Education In Ghana: An Evaluation Of The Junior High School Social Studies Curriculum, Benjamin Takyi, Anthony Bordoh Dr., Isaac Eshun Prof., Frederick Owusu

Journal of Educational Research and Practice

The aim of global citizenship education (GCE) is to equip individuals with the knowledge, skills, and values necessary to address global challenges. Despite its significance, GCE is often insufficiently integrated into curricula, particularly in the Global South. The purpose of the study was to examine the alignment of the junior high school standards-based social studies curriculum with GCE principles. Using a qualitative case study design and content analysis, the study explores cognitive, socio-emotional, and behavioral aspects of global citizenship embedded in the curriculum. The findings indicate a strong alignment between social studies learning outcomes and GCE principles, with content incorporating …

Tensions And Transformations: Equity, Diversity, And Inclusion In A Diverse Urban School Division, Lesley Eblie Trudel, Kishi Anderson Leachman, Wayne Davies

Journal of Educational Research and Practice

This study examines how equity, diversity, and inclusion (EDI) are understood and implemented within a large, diverse, urban school division in Canada. Using a mixed-methods approach and grounded in theoretical perspectives, including critical race theory, intersectionality, the ecology of inclusive education, and collective efficacy theory, we gathered insights from surveys and focus groups with educators, administrators, clinicians, educational assistants, caregivers, and students. Findings suggest that, while support for EDI is broad, the implementation is inconsistent and shaped by systemic barriers, resource constraints, and unclear leadership. We highlight the need for shared language, coordinated supports, and ongoing professional learning and instructional …

Clara White Mission, Inc. Mortgage Liquidation Campaign Leaflet

Eartha M. M. White Textual Material

Document: Leaflet soliciting donations for the Mortgage Liquidation campaign for the Clara White Mission. Eartha Mary Magdalene White Diamond (75th) Birthday Benefit Tribute Tickets 40 cents. Undated.

Postcard From Clara White Mission Soliciting Donations For The "Second Annual Fresh Air Encampment"

Eartha M. M. White Textual Material

Correspondence: Postcard soliciting donations for Fresh Air Encampment at Manhattan Beach, Jacksonville, Florida, sponsored by the Clara White Mission. Undated.

Sos Emergency Cash And Pledge Card For Donations, The Clara White Mission

Eartha M. M. White Textual Material

Document: Solicitation for donation to the Elevator Fund, Clara White Mission, Jacksonville, Florida. Undated.

Clara White Mission Solicitation Coin Folder

Eartha M. M. White Textual Material

Folder: "Please Help Clara White Mission Pay for Building This Home" coin gleaner. Undated.

Dr. Robert W. Bagnall Appearance At Pythian Auditorium Announcement

Eartha M. M. White Textual Material

Leaflet: Announcement of the appearance of Dr. Robert. W. Bagnall, Branch Director of the NAACP at the Pythian Auditorium, Jacksonville, Florida, February 8th. Handwritten notes on verso. Undated.

Postcard From Victor And Beulah To S. A. Austin

Eartha M. M. White Textual Material

Correspondence: Postcard wishing Mr. and Mrs. S. A. Austin, Strand Theatre, Jacksonville, Florida, Happy Easter, and Happy New Year from Victor and Beulah. Undated.