Digital Commons Network^™

Patterns Of Teaching And Professional Development Practices In Brazilian-Finnish Transnational Education, Terhi Skaniakos, Tahani Z. Aldahdouh, Johanna Annala, Pauliina Alenius, Vesna Holubek, Leonardo Drummond Vilaça, Vesa Korhonen

Journal of Comparative & International Higher Education

This study investigates teachers’ professional practices during the delivery of a transnational professional development programme by one Finnish university for a cluster of Brazilian private universities. The objective is to identify local instructors’ patterns of teaching (teachers’ personal-professional qualities), which are conceptualised as approaches to teaching and self-efficacy beliefs, as well as participation in professional development practices (professional cultures and professional development activities). An online questionnaire was sent to the teaching staff of five universities and 201 responses were received and analysed. The most important explanatory aspect was self-efficacy beliefs, which formed the basis for categorising teachers into meaningful clusters. …

Culturally Aware Mindfulness Training For Army Leaders: A Scalable Solution To Strengthen Mental Readiness, Katherine Dutler (Skowronski)

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This doctoral paper examines cost-effective, easily distributed mindfulness practices as a force-multiplier for psychological readiness in the U.S. Army. Daily mindfulness reduces symptom burden, raises distress tolerance, and sharpens performance—all without added equipment, appointments, or cost. However, stigma, long waitlists, and civilian-centric messaging still deter soldiers from adapting mindfulness practices. Rather than replacing clinicians, the program functions as preventive maintenance and a bridge while soldiers await care, thereby easing load on an overtaxed system. By embedding mental fitness alongside physical PT, the Army can advance its mandate to “deploy, fight, and win” with forces that are both mentally and physically …

Guide For Selecting Experimental Models To Study Dietary Fat Absorption, Andromeda M. Nauli, Ann Phan, Karen Mai, Kathleen Tran, Surya M. Nauli

Pharmacy Faculty Articles and Research

Dietary fat absorption is a complex, multi-step process involving digestion, enterocyte uptake, intracellular trafficking, re-esterification, and transport via lipoproteins into circulation. Because dietary fat absorption plays a central role in lipid homeostasis, metabolic syndrome, and fat malabsorption disorders, its study has a broad biomedical significance. However, experimental investigation of this process is technically challenging due to the short lifespan of enterocytes, the dual lymphatic and portal transport routes, and the need to trace the metabolic fate of absorbed lipids. This review summarizes and critically evaluates the major experimental systems used to study dietary fat absorption, highlighting their respective strengths, limitations, …

Mark Leclaire, Mark Leclaire, Juna Keehn

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Jack West, Jack West, Stephanie Mladinich

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Valorization Of Rice Bran For Functional Bioplastic Fabrication Using Plasma-Activated Water, Saydul Md Safwa, Muhammad Nazrul Islam, Keisha B. Walters, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

While plasma has been used for decades for the surface modification of packaging films, in this study, rice bran (RB) and rice bran protein (RBP) films were developed using plasma-activated water (PAW), and the chemical composition, surface structure modifications, surface properties, and thermal properties of these films were characterized. Fourier-transform infrared spectroscopy (FTIR) of the bran and protein films showed that the reactive species in PAW improved hydrogen bonding, as evidenced by the increase in the O-H stretching band at 3300 cm-1 and reduced peak intensity at 2940-2925 cm-1 (C-H stretching), suggesting oxidation of the aliphatic side chains. For the …

A Cluster-Randomized Controlled Trial Assessing The Effectiveness Of A Multifaceted Versus A Discrete Implementation Strategy On Fidelity To An Occupational Guideline For The Prevention Of Mental Health Problems At The Workplace: A Dual Perspective From Swedish Schools, Andreas Rödlund, Anna Toropova, Rebecca Lengnick-Hall, Byron J Powell, Liselotte Schäfer Elinder, Christina Björklund, Lydia Kwak

2020-Current year OA Pubs

BACKGROUND: Although the management of psychosocial risks in the work environment represents an evidence-based approach to the prevention of mental health problems, its implementation is limited, including in schools, and knowledge on how to support better implementation is scarce. This study compares the effectiveness of a multifaceted vs. a discrete implementation strategy on fidelity to an occupational guideline for the prevention of mental health problems. Dual perspectives were used to assess fidelity, an important aspect of the measurement agenda.

METHODS:  A cluster-randomized controlled trial was conducted among 55 schools in Sweden. A multifaceted strategy (educational meeting, implementation teams, ongoing training, …

Preliminary Investigation Of Cislunar Disposal Reachability Via Electric Propulsion For Selected L2 Lagrange Point Orbit Families, Ryan M. Sargent, Robert A. Bettinger, Carl R. Hartsfield

Faculty Publications

This paper investigates the disposal of end-of-life spacecraft from selected orbit families in the Earth-Moon system, specifically the L₂ Lyapunov and Halo families. Rather than focusing on impulsive burns with chemical propulsion systems, this paper examines disposal using continuous thrust generated by Hall thrusters, a form of electric propulsion. Leveraging the Circular Restricted Three Body Problem (CR3BP) as the dynamical framework, various levels of ΔV are evaluated in single-maximum burn and multiple-burn concepts of operation to evaluate the potential for spacecraft minimizing their transit of cislunar space and reaching the Earth’s gravitational sphere of influence in order to enter …

Mpox Insights: From Structure To Human Cell Interaction, Md. S. Zaman, Robert C. Sizemore, Draven Rodriguez, Emilio Lopez, S. M. Golam Alam, Suleyman Tufa, Juan C Lopez Alvarenga, Nuraly S. Akimbekov, Mohammed S. Razzaque

School of Medicine Publications

Mpox, a zoonotic viral disease, has emerged as a global concern due to outbreaks in both endemic and non-endemic regions in 2022. Rodents, including African squirrels and Gambian pouched rats, are suspected key reservoirs, with human infections occurring through direct contact with infected animals or bushmeat consumption. Previously confined to rural Africa, mpox has spread via international travel and the exotic pet trade. Human-to-human transmission occurs mainly via respiratory droplets and direct contact with bodily fluids or lesions. The virus has a double-stranded DNA genome within a lipid envelope. Despite lower mutation rates in DNA viruses, mpox has developed mutations, …

Exploring The Interplay Between Hypertension And Osteoporosis: A Narrative Review, Yolanda V. Gutierrez, Ronald Shaju, Alyssa A. Sepulveda, Seval Coban

School of Medicine Publications

Hypertension and osteoporosis are highly prevalent chronic conditions that have significant implications for global health, especially in aging populations. While these conditions have traditionally been viewed as separate, emerging research suggests a strong pathophysiological link between the two. Understanding these shared mechanisms may help improve screening and guide integrated management strategies. This narrative review was conducted between January 2024 and July 2025 using PubMed, ScienceDirect, and Google Scholar. The search strategy used the Boolean string: (“hypertension” OR “high blood pressure”) AND (“osteoporosis” OR “bone loss”), supplemented with pharmacologic terms (“ACE inhibitors,” “angiotensin receptor blockers,” “thiazide diuretics,” “beta-blockers”, “SERMS”, “Bisphosphonates”, “Denosumab”, …

Intramural Competition, Trial Competition Team

Student Organizations

Friday, November 21, 2025

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Kevin T Nead, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …

Integrative Profiling Strategies To Guide Personalized Therapy In Mantle Cell Lymphoma: A Pilot Study, Yang Liu, Holly A Hill, Yijing Li, Joseph Mcintosh, Vivian Jiang, Yixin Yao, Jared Zhang, Lawrence Qu, Jun Yao, Preetesh Jain, Ken Chen, Michael Wang

Faculty, Staff and Student Publications

Mantle cell lymphoma (MCL) responds to frontline therapy but is susceptible to relapse. While Bruton's tyrosine kinase inhibitors (BTKi) achieve high response rates, most patients eventually experience disease progression. Predicting responses to subsequent treatments remains challenging due to the lack of an established platform. Heterogeneity in gene alterations and cellular pathways contribute to resistance, complicating treatment approaches. Here, we present a multi-modal profiling platform, targeting key pathways rather than focusing on singular DNA-associated lesions. We identified dysregulated signaling pathways by performing gene expression profiling on 20 MCL samples using a custom MCL MATCH gene set and analyzed the data with …

Exploring The Perceived Management Priorities Between Physiotherapy And Osteopathy For Chronic Low Back Pain, Mollie Ford, Alec Rickard

School of Health Professions

Purpose:Physiotherapists and osteopaths are integral to the management of chronic low back pain (CLBP), yet patient confusion often arises due to overlap in their roles and techniques. Whilst existing literature has examined the approaches of each profession separately, limited research explores the perceived roles and management priorities. Thus, the aim of this study was to explore the perceived roles and management priorities of physiotherapists and osteopaths in addressing CLBP.Methods:A qualitative phenomenological design was used. Individual online semi-structured interviews were conducted with five UK-based healthcare professionals; two physiotherapists and three osteopaths. Participants were recruited through volunteer sampling and data was collected …

Impact Of Peek Implant Surface Design On Postoperative Complications In Cranioplasty: A Retrospective Review, Carmen A Zavala, Laura Zima, Subhiksha Srinivasan, Sanjay V Neerukonda, Mark J Dannenbaum

Faculty, Staff and Student Publications

Background: The aim of this study was to evaluate and compare complication rates and clinical outcomes associated with smooth and perforated polyetheretherketone (PEEK) implants used in cranioplasty.

Methods: A retrospective analysis of 94 patients who underwent cranioplasty with either smooth (n = 45) or perforated (n = 49) PEEK implants over a five-year period was conducted. Patient demographics, comorbidities, reasons for initial craniectomy, time interval between craniectomy and cranioplasty, postoperative complications, hospital stays, and rates of revision surgeries were analyzed. Multivariate logistic regression was used to control for confounding factors.

Results: No statistically significant differences were observed in demographic characteristics, …

Diras3-Derived Cyclic Peptides Disrupt Kras-Raf Interaction And Kras Nanoclustering, Suppressing Kras-Driven Pancreatic And Ovarian Tumors, Margie N Sutton, Jing Wang, Amarachi O Osuji, Nefeli Batistatou, Hailing Yang, Weiqun Mao, Zhi Tan, Geneviève M C Gasmi-Seabrook, Junchen Liu, John F Hancock, Christopher B Marshall, Joshua A Kritzer, Mitsuhiko Ikura, Robert C Bast, Steven W Millward, Zhen Lu

Faculty, Staff and Students Publications

Mutations in KRAS drive 88% of pancreatic ductal adenocarcinomas (PDAC) and up to 40% of low-grade serous ovarian cancers (LGSOC), making KRAS a long-standing therapeutic target. We previously showed that DIRAS3 binds RAS, forming heterodimers that disrupt RAS clustering and downstream MAPK signaling. Building on this, we developed conformationally constrained DIRAS3-derived peptides using two cyclization strategies and characterized them by NMR and biolayer interferometry. These cyclic peptides attenuate the interaction between KRAS and the BRAF RAS-binding domain, penetrate cells efficiently, and inhibit KRAS nanoclustering on the inner leaflet of the plasma membrane. Functionally, they reduce cell viability and suppress PDAC …

Norms For Scaling Up Small And Sick Newborn Care: An Overview Of Reviews, Natalie A. Strobel, Georgia Whisson, Derek Swe, Amy Budrikis, Karen M. Edmond

Research outputs 2022 to 2026

Background: The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) currently have no benchmarks or 'norms' for scaling up small and sick newborn (SSN) service delivery in health facilities in low- and middle-income countries (LMICs). Our objective was to understand which systematic reviews had addressed the following norms in the last five years: number of SSN beds per live births in a district or similar administrative unit (admission beds); space requirements for SSN units, including mother-infant dyads (space); health workforce ratios in SSN units (workforce); and travel time to health facilities with SSN units (travel time). Methods: …

The Role Of Educators In Cultivating Self-Efficacy Among School-Leaver Enabling Students: Perspectives And Practices, Ana Larsen, Trixie James, Amy Robinson, Angela Jones, Matilda Coleman, George Lambrinidis, Rachel Daniel

Research outputs 2022 to 2026

In Australia, government-funded Enabling programs provide equitable pathways to higher education for students from diverse backgrounds, including increasing numbers of recent school-leavers. This collaborative autoethnographic study explores six Enabling educators’ lived experiences across five universities to understand how they perceive and cultivate self-efficacy among school-leaver students. Thematic analysis revealed three overarching areas: educators’ perceptions of students’ readiness for higher education, strategies used to develop self-efficacy, and barriers that constrain this work. Findings highlight the complexity of fostering self-efficacy in younger cohorts, who often display both overconfidence and low academic self-belief. Educators identified the importance of pedagogies of care, growth mindset, …

Barriers And Facilitators To Engaging With Academia: A Black Dental Student Perspective – Pilot Study., Amitha Ranauta, Favour Onwudiwe, Tanaka Anthony Jeremy Kadiyo, Obioma Mofiyinfoluwa Ukoha, Rachel Adebukola Anuoluwa Ogunleye, Vivienne Banke Onamusi, Nicole Meerah Elango, Oluwasola Helen Asaolu, Antonia Oluwatosin Oluwakemi Ajayi, Modupe Toluwanimi Osunkoya, Kaamilah Shitta-Bey, Amy Maame Aba Amanfu, Cathy Coelho, Alasdair Robertson, Julie Monk, Nikos Donos, Sally Hanks

Peninsula Dental School

Introduction This pilot study investigates barriers and facilitators to Black dental students' engagement with academic careers in dentistry, focusing on underrepresentation in academia despite efforts to diversify the workforce. Methods and results Through qualitative analysis of focus group discussions with Black dental students from two UK dental schools, several key themes emerged. Participants highlighted the importance of active patronage in addressing underrepresentation, advocating for proactive support systems beyond mere mentoring. They also emphasised the significance of various forms of capital – economic, cultural, and social – in shaping career trajectories and success in academia. Intersectionality, encompassing experiences of sexism, racism, …

Streamlining Sepsis Care And Enhancing Antibiotic Administration Efficiency Through Emergency Department Staff Nurse Education, Dafina Jamillah Skinner

Walden Dissertations and Doctoral Studies

Sepsis is a life-threatening medical emergency that requires rapid identification and treatment. Delays in administering antibiotics are directly associated with increased mortality, longer hospital stays, and higher complication rates. Without intervention, patients faced preventable harm, and the organization risked continued non-compliance with federal quality measures. This Doctor of Nursing Practice (DNP) project implemented a structured educational program for emergency department (ED) nurses to improve knowledge of evidence-based sepsis protocols. The practice-focused question asked: For nurses in the ED, will an educational intervention on sepsis recognition and antibiotic stewardship improve knowledge of timely antibiotic administration and blood culture acquisition? Twenty ED …

Effects Of Mental Health Clinician Characteristics And Education On Willingness To Treat Child Problematic Sexual Behavior, Debra Elise Hutchison

Walden Dissertations and Doctoral Studies

Children aged 12 and under who exhibit problematic sexual behavior (PSB) often face barriers to care due to clinicians’ limited willingness and effectiveness in treating this population. However, little is known about the factors that influence clinicians’ willingness to provide treatment. Grounded in Bowen’s family systems theory and Bandura’s self-efficacy theory, this study examined how differentiation of self (DoS), sexual intervention self-efficacy (SISE), sexual comfort, and sexual education/training affect clinicians’ willingness to treat child PSB. A quantitative, non-experimental survey design with a convenience sample of 63 clinicians with experience working with children used a multiple linear regression analysis that revealed …

Improving The Efficiency Of Interhospital Transfers Through Best Practices Of Care, Victoria Frink

Walden Dissertations and Doctoral Studies

The variability within interhospital transfers represents challenges for hospitals to maintain a standardized level of care for patients. This integrative review explored evidence-based healthcare interhospital transfer practices to improve outcomes and efficiency of care for patients. Under the framework of the Donabedian model of health quality, the study examined 28 empirical and nonempirical articles published from 2021–2025 for best practices to provide improvement measures towards care for transfer patients and increase support for healthcare personnel. These articles were analyzed for quality using the Johns Hopkins evidence-based practice model. Through analysis, seven themes were identified: improving interhospital communication, improving time-based care, …

Development Of Evidence-Based Clinical Practice Guidelines For Monitoring Diabetic Patients Using Smartphone Technology, Ganiyat Funmilayo Efuntoye

Walden Dissertations and Doctoral Studies

In this doctoral project, I developed and validated an evidence-based clinical practice guideline for implementing smartphone technology to monitor diabetic patients in primary care settings with an 80% threshold. The project addressed a critical gap in standardized guidance for diabetes technology integration, which has resulted in inconsistent adoption and suboptimal patient outcomes. A systematic literature review of four major databases yielded 12 high-quality studies representing all evidence levels (I–V) according to the Johns Hopkins evidence-based practice model. Evidence synthesis revealed strong and compelling evidence with consistent results supporting smartphone technology implementation, including HbA1c improvements of 0.4%–0.8%, sustained patient engagement rates …

Nursing Faculty Demographics, Attitude, Knowledge, And Integration Of Complementary And Alternative Medicine In Nursing Curriculum, Patricia L. Balistreri

Walden Dissertations and Doctoral Studies

Nurses have demonstrated positive attitudes toward complementary and alternative medicine (CAM); however, additional education is limited in nursing programs to prepare them to discuss and educate patients about these practices. Nursing faculty play a significant role in educating, mentoring, and influencing students’ knowledge levels and attitudes toward CAM. The purpose of this quantitative, non-experimental, cross-sectional study, guided by the CAM healthcare model, was to examine relationships among nursing faculty demographics, CAM knowledge, attitudes, and curriculum integration. The Knowledge, Attitudes, and Use of CAM survey was administered to 111 nursing faculty across multiple programs. Data were analyzed using multiple linear regression …

Differential Substance Use Screening Approaches Among Medical Providers Based On Pregnancy Status, Ericka L. Suarez-Vella

Walden Dissertations and Doctoral Studies

Exploring medical providers’ role in relation to pregnant individuals who use substances is critical. Understanding how screening practices and provider biases influence addiction treatment referrals based on pregnancy status can help address several key issues, including potential disparities resulting from provider bias. It can ensure fair referral practices, promote equitable access to treatment, and ensure timely intervention resulting in better health outcomes. It can influence changes to policy and procedure among healthcare and judicial establishments, ultimately improving the relationship between providers and patients. The purpose of this study was to explore how medical providers’ screening practices of substance use in …

The Experience Of Black Mothers Preparing Their Black Sons For Race-Related Risks, Yamilka Torres

Walden Dissertations and Doctoral Studies

Despite progress in addressing racism in the United States, its effects remain deeply entrenched, particularly for Black families. Research on Black parenting shows that parents adapt their strategies to protect children from criminalization, discussing violence, providing safety within the home, and limiting exposure to unsafe environments while also managing their own stress. Yet limited attention has been given to how Black mothers prepare their sons for race-related risks within the modern sociopolitical climate shaped by the #BlackLivesMatter movement. The purpose of this basic qualitative research study was to explore how Black mothers prepare their Black sons for race-related risks. Carter’s …

Reproducibility In Modeling Of Knee Joint Mechanics, Maryam Nazem

Electronic Theses and Dissertations

Computational modeling of knee joint biomechanics can provide valuable insights into joint function, injury mechanisms, and patient outcomes, and can support surgical planning and informed clinical decision-making. However, achieving consistent and repeatable results, or reproducibility, is a significant challenge that affects the credibility of these models. This thesis addresses reproducibility through two studies related to the KneeHub Project, which is a multi-institutional collaboration designed to investigate reproducibility in finite-element modeling of the knee.

The first study involved model benchmarking, where predicted results of the calibrated models were compared with the experimental data to evaluate model reproducibility. While all models replicated …

Antiadhesive Glycoconjugate Metal Complexes Targeting Pathogens Pseudomonas Aeruginosa And Candida Albicans, Karolina Wojtczak, Emilie Gillon, Diana Bura, Karen Richmond, Megan Joyce, Emma Caraher, Keela Kessie, Trinidad Velasco-Torrijos, Cristina Trujillo, Anne Imberty, Kevin Kavanagh, Gordon Cooke, Joseph P. Byrne

Research Outputs: 2025-Present

Glycoconjugates are known to interact with carbohydrate-binding proteins involved in adhesion by pathogens, and offer opportunities to design antimicrobial agents. Metal complexes with Eu(iii), Ni(ii) and Zn(ii) were prepared from glycoconjugate ligand 1Gal, which binds to P. aeruginosa's lectin LecA (K_d 9.6 ± 0.7 μM). In vitro anti-adhesive activity of these compounds was evaluated for both P. aeruginosa and C. albicans. Choice of metal ion played a crucial role in modulating anti-adhesive activity, with Eu(iii) complexes most effective: [Eu·(1Gal)(H₂O)₆](CF₃SO₃)₃ inhibits 60% biofilm formation by P. aeruginosa and [Eu·(1Gal)₃](CF …

Deletion Of Fibro-Adipogenic Progenitors-Specific Follistatin Impairs Muscle Function And Accelerates Skeletal Muscle Atrophy In Obese Mice, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki Miwa, Takumi Era, Martin M Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe

Faculty, Staff and Students Publications

Background: Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury. The mechanism by which fibro-adipogenic progenitors (FAPs)-specific follistatin influences muscle homeostasis in obese mice remains unknown. Therefore, we investigated the physiological role of follistatin in PDGFRα-positive FAPs in the regulation of muscle homeostasis and exercise in obese mice.

Methods: A PDGFRα-specific follistatin knockout (follistatin KO) mouse model was generated using PDGFRα-GFP-CreERT2 (PDGFRα-GCE) and follistatinflox/flox mice. These mice were fed a 60% high-fat diet (HFD) for 20 weeks, followed …

Multi-Parametric Profiling Of Il-7-Augmented Gd2cart Products In A Phase 1 Clinical Trial, Lukas Ehlen, Stephan Schlickeiser, Samira Picht, Lena Peter, Marco Mai, Candise L Tat, Jacqueline Keye, Desiree Kunkel, Frank Lin, Cliona M Rooney, Bilal Omer, Michael Schmueck-Henneresse

Faculty, Staff and Students Publications

CAR T cell (CART) therapy holds promise for cancer treatment, but heterogeneity among products limits clinical effectiveness, making systematic profiling essential to identify predictors of success. Recently, a phase 1 clinical trial investigated whether a constitutively active IL-7 receptor (C7R) could safely improve the function and persistence of GD2-directed CARTs (GD2.CARTs) in pediatric patients with high-grade CNS tumors. We analyzed infusion products from trial participants using a custom-designed 33-color full spectrum flow cytometry (FSFC) panel combined with an image-based tumor killing assay to characterize CART products and evaluate the impact of C7R on GD2.CART performance. Patient-specific variations in T cell …