Digital Commons Network^™

Rurality’S Impact On Alaska Native Elders’ Levels Of Physical Activity And Obesity, Jessie Doherty

Walden Dissertations and Doctoral Studies

While there have been studies on obesity levels and physical activity levels across many populations and age groups, few studies have focused on Alaska Native Elders. The purpose of this study was to examine rurality (urban vs. rural counties), physical activity, and obesity level while controlling for sex, self-reported loneliness, and self-reported stress. The theoretical foundation for this study was based on the socio-ecological model (SEM), and the research questions in this study explored how rurality impacted obesity levels and how rurality impacted physical activity levels in Alaska Native Elders. The methodology of this study was a quantitative cross-sectional design …

Effective Organizational Succession Planning Strategies For Retaining Knowledge From Retiring Employees, Rodriquez Tremayne Brown

Walden Dissertations and Doctoral Studies

A lack of succession planning to retain critical knowledge from retiring employees poses significant risks to organizational revenue and long-term survival. Organizational leaders are particularly concerned about succession planning because failure to capture employee knowledge threatens organizational performance and survival. Grounded in the 7-step model for succession planning theory, the purpose of this qualitative pragmatic inquiry project was to identify and explore effective succession planning strategies that some organizational leaders use to retain knowledge from retiring employees to avoid a negative impact on organizational revenue and survival. The participants included eight senior human resource managers from different organizations in the …

An Examination Of Successful Reentry And Recidivism For Drug-Involved Offenders In Rural Areas, Jacqueline Cottle

Walden Dissertations and Doctoral Studies

In rural communities, treatment and supportive resources are limited, putting ex-offenders (EXOs) at an increased risk for relapse or recidivism. The purpose of this qualitative study was to understand, through semistructured interviews, the experiences of EXOs who completed the court residential treatment center, intermediate sanction facility, or substance abuse felony punishment facility, and returned to a rural county in Texas, along with the perspectives of 11 community supervision officers who worked closely with the EXOs. This study was guided by Agnew’s general strain theory, which posits that drug-involved offenders achieve successful reentry in rural areas when positive supports are present, …

New Avenues In Childhood Vasculitis, Hulya Ercan Emreol, Cagri Yildirim-Toruner, Marija Jelusic, Marinka Twilt, Seza Ozen

Faculty, Staff and Students Publications

Childhood vasculitis encompasses a group of rare and heterogeneous diseases with systemic inflammation affecting various vessel sizes. This comprehensive review highlights recent advances in the pathogenesis, biomarkers, diagnosis, and treatment strategies for major pediatric vasculitides including IgA vasculitis, Kawasaki Disease, ANCA-associated vasculitis, Takayasu arteritis, and Polyarteritis Nodosa. Novel insights from genetic, immunologic, and imaging studies have paved the way for early diagnosis and individualized therapeutic approaches. Future directions emphasize the role of artificial intelligence, precision medicine, and international collaborative trials to optimize long-term outcomes and quality of life in affected children.

Practicing With Intent: How To Teach An Old Dogma New Tricks, Matthew C Phillips, Kusha Davar, Sarah Freling, Steven Y C Tong, Todd C Lee, Emily G Mcdonald, Travis B Nielsen, Noah Wald-Dickler, Alfredo J Mena Lora, Rachael A Lee, Fergus Hamilton, Daniel M Musher, Rodrigo P L Costa, Bassam Ghanem, Rachel Baden, Brad Spellberg

Faculty, Staff and Students Publications

Clinicians are constantly bombarded with an onslaught of newly published data, yet they must make clinical decisions despite a dearth of clinical data. Sometimes, they may fall back on clinical practices entrenched by experience, unaware that they are upheld by dogmatic tradition rather than robust evidence. Ideally, the totality of evidence must be assessed and utilized for clinical decision-making, irrespective of entrenched orthodoxy. Here, we explore the questions, how much evidence is needed to revise established clinical practices and, more fundamentally, can data alone truly catalyze such shifts.

A Supplement, Not A Substitute: Accuracy And Completeness Of Chatgpt Responses For Common Elbow Pathology, Benjamin Fiedler, Umar Ghilzai, Abdullah Ghali, Phillip Goldman, Pablo Coello, Michael B Gottschalk, Eric R Wagner, Adil Shahzad Ahmed

Faculty, Staff and Students Publications

Hypothesis: Large language models (LLMs) like ChatGPT have increasingly been used as online resources for patients with orthopedic conditions. Yet there is a paucity of information assessing the ability of LLMs to accurately and completely answer patient questions. The present study comparatively assessed both ChatGPT 3.5 and GPT-4 responses to frequently asked questions on common elbow pathologies, scoring for accuracy and completeness. It was hypothesized that ChatGPT 3.5 and GPT-4 would demonstrate high levels of accuracy for the specific query asked, but some responses would lack completeness, and GPT-4 would yield more accurate and complete responses than ChatGPT 3.5.

Methods: …

Strain-Specific Variability In Viral Kinetics, Cytokine Response, And Cellular Damage In Air-Liquid Cultures Of Human Nasal Organoids After Infection With Sars-Cov-2, Gina M Aloisio, Trevor J Mcbride, Letisha Aideyan, Emily M Schultz, Ashley M Murray, Anubama Rajan, Erin G Nicholson, David Henke, Laura Ferlic-Stark, Amal Kambal, Hannah L Johnson, Elina A Mosa, Fabio Stossi, Sarah E Blutt, Pedro A Piedra, Vasanthi Avadhanula

Faculty, Staff and Students Publications

SARS-CoV-2 variants have demonstrated distinct epidemiological patterns and clinical presentations throughout the COVID-19 pandemic. Understanding variant-specific differences at the respiratory epithelium is crucial for understanding their pathogenesis. Here, we utilized human nasal organoid air-liquid interface (HNO-ALI) cell cultures to compare the viral replication kinetics, innate immune response, and epithelial damage of six different strains of SARS-CoV-2 (B.1.2, WA, Alpha, Beta, Delta, and Omicron). All variants replicated efficiently in HNO-ALIs, but with distinct replication kinetic patterns. The Delta variant exhibited delayed replication kinetics, achieving a steady state at 6 days post-infection compared to 3 days for other variants. Cytokine analysis revealed …

Tillage Legacy, Grasses And Soil Texture Shape Soil Organic Carbon Recovery In Semi-Arid Woodland, Samantha Colunga, Alejandro Fierro-Cabo, Bradley O. Christoffersen, Engil Pereira

School of Earth, Environmental, & Marine Sciences Faculty Publications

Soil degradation from intensive tillage poses a critical barrier to carbon sequestration, particularly in semi-arid regions where low rainfall limits ecosystem recovery. As climate change expands arid zones globally, understanding the long-term potential for soil organic carbon (SOC) recovery in degraded lands becomes increasingly urgent. Here, we analyze reforested chronosequences (4–36 years post-abandonment) in formerly cultivated subtropical thornscrub woodlands to assess SOC dynamics across gradients of soil texture and degradation. We introduce a novel degradation index (DI), integrating SOC deficit and grass dominance, to evaluate how invasive grasses, commonly overlooked in restoration metrics, impede nitrogen (N2)-fixing tree establishment and, consequently, …

Fema Public Policy Impacts On Emergency Preparedness In Florida, Sara Sambolin

Walden Dissertations and Doctoral Studies

Older adults are at an increased risk of mortality during hazardous emergencies; therefore, it is crucial to comprehend how current emergency preparedness policies are related to preparedness perceptions of older adults. Findings in recent literature identified the underrepresentation of older adults in Emergency Preparedness studies across all areas and Counties of the state of Florida as a gap that needs to be addressed. The purpose of this quantitative correlational study was to examine the relationship between the 2023 FEMA policy on emergency preparedness and the self-reported degree of preparedness among Florida’s older adult residents in urban and rural areas across …

Student Life E-Newsletter October 6, 2025, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Re: Butte Priority Soils Operable Unit (Bpsou) Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 45 – Garfield, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Annual Alumni Mixer, Latin American Law Students Association (Lalsa)

Student Organizations

Monday, October 6, 2025

Mmu: 10/06/25-10/12/25, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

Saint of the Week

General Announcements

Investigating Factors Influencing Organic Chemistry Learners' Explanation Sophistication And Representational Competence, Caroline J. Crowder

USF Tampa Graduate Theses and Dissertations

The research presented in this dissertation has two themes: organic chemistry learners’ written explanations and representational competence. Chapters 3 and 4 explore how organic chemistry learners construct explanations of reaction mechanisms, specifically focusing on electrophile and nucleophile components. Chapter 5 investigates organic chemistry learners’ representational competence skills and the relationship between these skills and their performance in the course.

Understanding reaction mechanisms is critical for success in organic chemistry, yet learners often struggle to reason beyond explicit, surface-level features. Constructed-response prompts that ask learners to explain what is happening in a reaction mechanism and why it occurs can provide insight …

Apoe-Calypse Tau: Apoe-Tau Synergy In Alzheimer's Disease, Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D Ulrich, David M Holtzman, Maud Gratuze

2020-Current year OA Pubs

Alzheimer's disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. While much of the research has focused on Aβ, tau-mediated neurodegeneration is more closely associated with synaptic loss and cognitive decline in AD, emphasizing the need for a deeper understanding of tau pathology. In this context, the interaction between tau and APOE, particularly the main genetic risk factor for AD APOE ε4, remains underexplored. APOE encodes apolipoprotein E (apoE), a protein important in lipid metabolism. In addition to promoting Aβ deposition, emerging …

Investigation Of Lncrna Expression In Newly Diagnosed Multiple Myeloma Reveals A Linc01432-Celf2 Axis As An Inhibitor Of Apoptosis, Richa Mishra, Prasanth Thunuguntla, Dhanusha Duraiyan, Alani Perkin, Katelyn Bagwill, Savannah Gonzales, Catheryn Sizemore, Vanessa Brizuela, Jaiyana King, Stephen Daly, Yoon Jae Chang, Mahdote Abebe, Yash Rajana, Kelly Wichmann, Christ Enyan, Shruthi Rangineni, Mark Fiala, Julie Fortier, Reyka Jayasinghe, Mark Schroeder, Li Ding, Ravi Vij, John Dipersio, Jessica Silva-Fisher

2020-Current year OA Pubs

Multiple myeloma (MM) is an incurable malignancy of plasma cells, with over 35,000 new cases diagnosed annually in the United States. Despite an expanding arsenal of approved therapies, nearly all patients relapse, and mechanisms underlying disease progression remain poorly understood. In particular, the role of long non-coding RNAs (lncRNAs) in MM progression and treatment response is largely unexplored. To address this gap, we performed transcriptome sequencing of newly diagnosed MM (NDMM) patient samples and compared individuals with short progression-free survival (PFS; < 24 months) to those with prolonged PFS (>24 months) following standard first-line therapy. We identified 157 lncRNAs upregulated in patients with short PFS, and prioritized the …

Isothermal Sloshing In A Circular Tank (Ccp-Wsi Test Case 017 Dataset), Scott Brown, Stuart Colville, Yeaw Chu Lee, Deborah Greaves

Faculty of Science and Engineering Datasets

Physical modelling dataset used for CCP-WSI Blind Test Series 5. The description is available on the CCP-WSI catalogue under "Test Case ID 017": https://ccp-wsi.ac.uk/catalogue/test_cases/test_case_017

Atg Conjugation-Dependent/Independent Mechanisms Underlie Lysosomal Stress-Induced Tfeb Regulation, Shiori Akayama, Takayuki Shima, Tatsuya Kaminishi, Mengying Cui, Jlenia Monfregola, Kohei Nishino, Andrea Ballabio, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura

Duncan NRI Faculty and Staff Publications

TFEB, a master regulator of autophagy and lysosomal biogenesis, is activated by several cellular stresses including lysosomal damage, but its underlying mechanism is unclear. TFEB activation during lysosomal damage depends on the ATG conjugation system, which mediates lipidation of ATG8 proteins. Here, we newly identify ATG conjugation-independent TFEB regulation that precedes ATG conjugation-dependent regulation, designated Modes I and II, respectively. We reveal unique regulators of TFEB in each mode: APEX1 in Mode I and CCT7 and/or TRIP6 in Mode II. APEX1 interacts with TFEB independently of the ATG conjugation system, and is required for TFEB stability, while both CCT7 and …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Inflammation And Mutational Burden Differentially Associated With Nivolumab Or Ipilimumab Combination Efficacy In Colorectal Cancer, Ming Lei, Michael J Overman, Jin Yao, Thierry André, Sara Lonardi, Heinz-Josef Lenz, Massimo Aglietta, Fabio Gelsomino, Ray Mcdermott, Ka Yeung Mark Wong, Michael A Morse, Eric Van Cutsem, Alain Hendlisz, Dana B Cardin, Bart Neyns, Andrew Hill, Anuradha Krishnamurthy, Franklin Chen, Samith Kochuparambil, Robert R Jenq, Sandzhar Abdullaev, Beilei He, Ruslan Novosiadly, Scott Kopetz

Faculty, Staff and Student Publications

Nivolumab alone and in combination with ipilimumab demonstrated durable clinical benefit in patients with previously treated microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer in the phase 2 CheckMate 142 study. Here, we report exploratory biomarker analyses from CheckMate 142 evaluating associations between various tissue biomarkers and the efficacy of nivolumab monotherapy and nivolumab plus ipilimumab combination in these patients. Higher expression of inflammation-related gene expression signatures is associated with improved response per investigator assessment and survival benefit with nivolumab monotherapy. In contrast, higher tumor mutational burden, tumor indel burden, and degrees of microsatellite instability are associated with improved response per investigator …

Quantitative Proteomics Identifies Conserved Proteins And Altered Regulation Of Mucin-16 In Low Grade Serous Ovarian Cancers, Christopher M Tarney, Paulette Mhawech-Fauceglia, Jonathan D Ogata, Julie Oliver, Tamara Abulez, Philip A Branton, Saeid Movahedi-Lankarani, Brian L Hood, Kelly A Conrads, Kendal Rosalik, Kwong-Kwok Wong, David M Gershenson, Sanghoon Lee, Anil K Sood, Robert C Bast, Kathleen M Darcy, Neil T Phippen, G Larry Maxwell, Thomas P Conrads, Nicholas W Bateman

Faculty, Staff and Student Publications

BACKGROUND: Low-grade serous ovarian carcinoma (LGSOC) is a rare and largely chemoresistant subtype of epithelial ovarian cancer. Unlike treatment for high-grade serous ovarian cancer (HGSOC), management options for LGSOC patients are limited, in part, due to a lack of deep molecular characterization of this disease. To address this limitation, we aimed to define highly conserved proteome alterations in LGSOC by performing deep quantitative proteomic analysis of tumors collected from LGSOC and HGSOC patients or normal fallopian tube tissues and validating proteins within two independent proteomic datasets of LGSOC and HGSOC tumors.

METHODS: Formalin-fixed, paraffin-embedded LGSOC (n = 12), HGSOC (n …

Atg16l1 Controls Mammalian Vacuolar Proton Atpase, Thabata L A Duque, Masroor Paddar, Einar Trosdal, Ruheena Javed, Lee Allers, Michal H Mudd, Prithvi Akepati, Soumya R Mishra, Michelle Salemi, Brett Phinney, Shawn B Bratton, Thomas Wileman, Vojo Deretic

Faculty, Staff and Student Publications

The mechanisms governing mammalian proton pump V-ATPase function are of fundamental and medical interest. The assembly and disassembly of cytoplasmic V1 domain with the membrane-embedded V0 domain of V-ATPase is a key aspect of V-ATPase localization and function. Here, we show that the mammalian protein ATG16L1, primarily appreciated for its role in canonical autophagy and in noncanonical membrane atg8ylation processes, controls V-ATPase. ATG16L1 knockout elevated V-ATPase activity, increased V1 presence on endomembranes, and increased the number of acidified intracellular compartments. ATG16L1's ability to efficiently bind V-ATPase was required for its inhibitory role in endolysosomal acidification and for control of Mycobacterium …

Assessing A Community Health Worker-Facilitated, Digitally Delivered, Family-Centered Diabetes Management Program: Single-Arm Quasi-Experimental Study, Zenong Yin, Vanessa L Errisuriz, Heather Cuevas, Bertha E Flores, Laura Delfausse, Christina Galvan, Jing Wang, Chengdong Li, Renata Morfin, Shiyu Li, Maysa Sapargeldiyeva, Giliane Yza Muyna, Minyu Zhang, Vanessa Sweet, Deborah Parra-Medina

Faculty, Staff and Student Publications

Background: The high prevalence of type 2 diabetes (T2D) and associated complications disproportionately affect low-income Latino populations, who also experience disparities in diabetes self-management (DSM), including poor medication adherence, physical activity, diet, and glycemic control.

Objective: This study examined, through an academic-community partnership, the effectiveness of ¡Salud, Salud! (an evidence-based, family-centered diabetes self-management education and support [DSMES] program) on primary (glycemic control and quality of life) and secondary (social, psychological, and behavioral factors related to T2D management) outcomes among low-income Latino adults with T2D or prediabetes.

Methods: In total, 81 adults (mean age 48.90 years, SD 12.57; n=57, 70.4%, female; …

Squamous Non-Small Cell Lung Cancer: Current And Emerging Treatment Options, Paul K Paik, Jianjun Zhang, Howard Jack West, Jonathan W Riess

Faculty, Staff and Student Publications

Although the pharmacologic management of non-small cell lung cancer (NSCLC) has advanced substantially in the past 2 decades, disparities in the applicability to different histologic subtypes remain. Several treatment options are not suitable for squamous NSCLC, with use restricted to nonsquamous NSCLC (eg, bevacizumab and pemetrexed) because of safety concerns or comparative activity. Differences in mutational landscapes and a lack of matched targeted therapies specific to squamous NSCLC oncogenic aberrations present additional limitations. In the absence of suitable targeted therapies, immunotherapy with or without chemotherapy is the mainstay of squamous NSCLC treatment; however, survival-related outcomes remain poorer for patients with …

Westminster Apts. Llc V. Deetjen

All Decisions

In this nuisance/breach of lease holdover proceeding, the tenant moved to dismiss, arguing the landlord's petition was defective for failure to serve a 30-day termination notice under the federal CARES Act, as the property had a federally backed mortgage. The court denied the motion, holding that the CARES Act's 30-day notice requirement applies exclusively to non-payment proceedings, not to holdover proceedings based on nuisance or lease breach. The court found that subsections (b) and (c) of 15 U.S.C. § 9058 must be read in unison, and the notice provision (c) is implicitly limited by subsection (b)'s express reference to non-payment …

Lenox Twins Llc V. Watson

All Decisions

In this rent-stabilized nuisance holdover proceeding, the tenant moved for summary judgment to dismiss the petition, while the landlord cross-moved to amend the petition. The court found the landlord's predicate notice sufficiently detailed the alleged nuisance conduct. However, the tenant presented a sworn affirmation flatly denying the nuisance allegations, including throwing garbage from windows. The landlord failed to offer any rebuttal from an individual with personal knowledge or competent corroborating evidence. Consequently, the court granted the tenant's motion for summary judgment, dismissing the petition, and denied the landlord's cross-motion as moot.

Phytochemisty And Antioxidant Activity Of Ethanol, Ethyl Acetate, And N-Hexane Extracts Of Suruhan Leaves (Peperomia Pellucida), Ade Arsianti, Steven Gill, Diyah Kristanty

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Free radicals are natural byproducts of cellular metabolism, in which, their excessive accumulation can lead to oxidative stress, which plays a key role in the development of various chronic diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Antioxidants are compounds capable of scavenging free radicals and minimizing oxidative damage. Peperomia pellucida, commonly known as Suruhan leaves, is a tropical herb traditionally used in folk medicine that contain bioactive compounds correlated with a strong radical-scavenging activity, suggesting its potential as a natural antioxidant source. This study aims to conduct a phytochemical analysis and evaluate the antioxidant activity of ethanol, …

Retrospective, Single-Center Assessment Of A Pharmacist-Led Anti-Methicillin-Resistant Staphylococcus Aureus (Mrsa) Therapy Bundle To Enhance Antimicrobial Stewardship, Jeyma Fernandez, Alice Margulis Landayan, Jorge Murillo, Stephen Breazeale, Timothy Gauthier

All Publications

No abstract provided.

Follow Me Into Math: Near-Peer Influencers Take The Stage, Aaron T. Wilson, Sergey Grigorian, Mayra Ortiz Galarza, Xiaohui Wang

School of Mathematical & Statistical Sciences Faculty Publications

Young people like to be entertained, and to entertain others. What if students were to invest enough of their time and effort into learning topics from our mathematics courses to become experts in the eyes of their peers? In this study we positioned college students and high school students as mathematical performers on the stage in front of their nearpeers, for whom they became math influencers, developing and presenting MathShows. The paper shows readers how we positioned students on the stage, using a 7-step MathShow Design Process informed by a Neer-peer Mathematical Mentoring framework. Of import for educators, researchers and …

Understanding The Role Of Street Medicine In Harm Reduction: A Case Study Of Street Medicine St. Louis, Ari Gzesh, Jeremiah S Truel, Danielle R Adams, Luke Zabotka, Sara Malone, Nathanial S Nolan

2020-Current year OA Pubs

BACKGROUND: Homelessness results from, and exacerbates, various social determinants of health, including poverty, racism, and inadequate healthcare access, which are further compounded by physical and mental health challenges. The street medicine movement seeks to address these disparities by providing direct medical care and harm reduction services to unsheltered homeless in low-barrier settings. The development of trust is critical to providing this form of care. Few studies have sought to understand the factors influencing trust development in street medicine encounters.

METHODS: This case study of Street Medicine St. Louis aims to explore the factors that influence trust and how trust development …