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Articles 126361 - 126390 of 5156547
Full-Text Articles in Entire DC Network
In Memoriam, Hadi Sidomulyo (1951-2024), Wayan Jarrah Sastrawan
In Memoriam, Hadi Sidomulyo (1951-2024), Wayan Jarrah Sastrawan
Wacana, Journal of the Humanities of Indonesia
No abstract provided.
Understanding Tobacco Use Among Bangladeshi Men: A Socio-Demographic Analysis Of Risk Factors, Md. Rashedus Salekin Sabbir, Helal Uddin, Md Shazid Hossain Shohan
Understanding Tobacco Use Among Bangladeshi Men: A Socio-Demographic Analysis Of Risk Factors, Md. Rashedus Salekin Sabbir, Helal Uddin, Md Shazid Hossain Shohan
Indonesian Journal of Public Health Nutrition (IJPHN)
Tobacco consumption remains a major public health concern in Bangladesh, where adult males represent the most affected group. Despite existing bans on public smoking, cultural norms, media influence, and limited awareness continue to sustain high prevalence. The objective of this study was to examine the socio-demographic determinants of tobacco use among Bangladeshi men, focusing on regional variation, education, media exposure, and family influence. A cross-sectional survey was conducted among 275 adult males in Dhaka Division using a structured questionnaire. Data was analyzed through descriptive statistics, chi-square tests, and binary logistic regression to identify significant predictors of tobacco consumption. Findings reveal …
The Relationship Between Anemia, Chronic Energy Deficiency, Knowledge, And Other Factors And Anc Attendance Among Pregnant Women In Bogor City And Regency 2025, Winfried Ichtussend Hartnajaya Chrisna, Ratu Ayu Dewi Sartika, Nurul Dina Rahmawati, Daden Setiawan
The Relationship Between Anemia, Chronic Energy Deficiency, Knowledge, And Other Factors And Anc Attendance Among Pregnant Women In Bogor City And Regency 2025, Winfried Ichtussend Hartnajaya Chrisna, Ratu Ayu Dewi Sartika, Nurul Dina Rahmawati, Daden Setiawan
Indonesian Journal of Public Health Nutrition (IJPHN)
Antenatal Care (ANC) is a comprehensive health service to optimize pregnancy outcomes. In 2023 in Bogor City, the ANC K6 coverage rate has reached the target (98.63%), but this is not the case with the coverage in Bogor Regency (62.25%). ANC visits that do not reach the standard can be influenced by predisposing factors, supporting factors, and health needs factors. The inequality that occurs can hinder efforts to reduce maternal mortality. This study aims to determine the relationship between knowledge and other factors with ANC visits in Bogor City and Regency in 2025. This study is quantitative with a cross-sectional …
Determinants Of Abdominal Obesity In Adults (19 – 44 Years Old) In Riau Islands Province (Analysis Of Ski 2023 Data), Hanifah Mulia Rachman, Triyanti Triyanti, Ratu Ayu Dewi Sartika, Kusharisupeni Djokosujono
Determinants Of Abdominal Obesity In Adults (19 – 44 Years Old) In Riau Islands Province (Analysis Of Ski 2023 Data), Hanifah Mulia Rachman, Triyanti Triyanti, Ratu Ayu Dewi Sartika, Kusharisupeni Djokosujono
Indonesian Journal of Public Health Nutrition (IJPHN)
Abdominal obesity is a condition characterized by excessive fat accumulation in the abdominal region, which can increases the risk of type 2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. In 2023, Riau Islands Province recorded the highest prevalence of abdominal obesity in the island of Sumatra, at 42.5%. This study aimed to analyze the determinants of abdominal obesity among adults aged 19–44 years in Riau Islands Province based on gender, using secondary data from the 2023 Indonesia Health Survey (SKI). A total of 3,466 respondents were analyzed using chi-square tests and multiple logistic regression. The results showed that the prevalence …
Proportion Of Chronic Energy Deficiency In Relation To Macronutrient Intake And Other Determinants Among Pregnant Women In Selected Community Health Center Service Areas In Bogor 2025, Fathimah Afliansa, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Suparno Suparno
Proportion Of Chronic Energy Deficiency In Relation To Macronutrient Intake And Other Determinants Among Pregnant Women In Selected Community Health Center Service Areas In Bogor 2025, Fathimah Afliansa, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Suparno Suparno
Indonesian Journal of Public Health Nutrition (IJPHN)
The prevalence of chronic energy deficiency (CED) among pregnant women in Indonesia remains relatively high, ranging from 11.6% to 57.6%. This study aimed to examine the differences in the proportion of CED based on macronutrient intake and related factors. The study used a quantitative cross-sectional design with secondary data involving 124 pregnant women in selected areas served by community health centers in Bogor City and Regency. Data were analyzed using the chi-square test. CED prevalence was 11.3% in the overall areas, with 10.9% in Bogor City and 11.7% in Bogor Regency. Significant differences in the CED proportion were found based …
Perceived Benefits And Side Effect Of High-Fiber, High-Protein Meal Replacements In Weight Loss Programs, Esti Nurwanti, Harry Fl Muhammad, Naufal M. Nurdin
Perceived Benefits And Side Effect Of High-Fiber, High-Protein Meal Replacements In Weight Loss Programs, Esti Nurwanti, Harry Fl Muhammad, Naufal M. Nurdin
Indonesian Journal of Public Health Nutrition (IJPHN)
Obesity is a major risk factor for chronic diseases and early mortality. Although dietary counseling is essential in managing obesity, maintaining a calorie deficit and preventing weight regain remain difficult. Functional foods like high-protein, high-fiber meal replacements may enhance adherence and support weight loss. This randomized controlled trial evaluated the subjective outcomes of a weight loss program incorporating a protein- and fiber-enriched meal replacement among 73 overweight women aged 20–30 years. Participants were randomized to an intervention group (n=38), receiving dietary counseling plus one daily meal replacement, or a control group (n=35), receiving counseling alone. Both groups followed an 8-week …
Analysis Of Macronutrient Content, Antioxidant Activity, And Organoleptic Quality Of Snack From Jackfruit Seed Flour (Artocarpus Heterophyllus) And Pigeon Pea Flour (Cajanus Cajanus) As A Snack For Patients With Type 2 Diabetes Mellitus, Maya Siwi Tri Nugroho Heni, Tesa Rafkhani
Analysis Of Macronutrient Content, Antioxidant Activity, And Organoleptic Quality Of Snack From Jackfruit Seed Flour (Artocarpus Heterophyllus) And Pigeon Pea Flour (Cajanus Cajanus) As A Snack For Patients With Type 2 Diabetes Mellitus, Maya Siwi Tri Nugroho Heni, Tesa Rafkhani
Indonesian Journal of Public Health Nutrition (IJPHN)
Type 2 diabetes mellitus characterized by chronic hyperglycemia and oxidative stress. Snack bars with functional ingredients such as legumes may help regulate blood glucose levels. Jackfruit seeds and pigeon peas are sources of protein, complex carbohydrates, and bioactive compounds. This study aimed to analyze macronutrient content, antioxidant activity, and organoleptic quality of jackfruit seeds and pigeon pea flour snack bars. This study used a completely randomized design (CRD) one factor with two replications. The proportions of jackfruit seeds and pigeon pea flour are: F1 (30%:70%), F2 (40%:60%), F3 (50%:50%). Macronutrient content was analyzed using proximate analysis, antioxidant activity using the …
Reframing Nutrition Policy For Under-Five Children In Thailand: Beyond The First 1,000 Toward 2,500 Days, Saipin Chotivichien, Waraporn Jitaree, Wareethip Phuengpan, Saiyed M. Hyder
Reframing Nutrition Policy For Under-Five Children In Thailand: Beyond The First 1,000 Toward 2,500 Days, Saipin Chotivichien, Waraporn Jitaree, Wareethip Phuengpan, Saiyed M. Hyder
Indonesian Journal of Public Health Nutrition (IJPHN)
Malnutrition continues to threaten child health globally, with Thailand mirroring this trend: in 2022, 12.4% of children under five were stunted, 7.2% wasted, and 10.9% obese. While the country’s First 1,000 Days initiative—targeting pregnancy to age two—yielded early success in reducing undernutrition, emerging gaps among 3–5-year-olds prompted a policy shift toward a broader 2,500-day framework. This approach, launched in 2022, extends care from preconception through age five and integrates multisectoral action involving five key ministries. Anchored in the “Power of Three Pillars”—policy, partnerships, and resources—the initiative strengthens local governance, enhances service delivery, and fosters family and community engagement through sub-district …
Mandating Fluoride: A Constitutional Exercise Of Police Power, Anita Jahangiri
Mandating Fluoride: A Constitutional Exercise Of Police Power, Anita Jahangiri
Seattle University Law Review
This Note addresses the ongoing debate over fluoridation: the regulation of fluoride levels in public water systems. Extensive research indicates fluoridation, when regulated at the recommended concentration, is both safe and highly effective in preventing dental caries. Better known as cavities, dental caries is a preventable yet widespread health issue that disproportionately affects low-income populations. Reducing dental health disparities among economic classes is a pressing public health issue. Fluoridation is not merely a policy option, but a critical, proven tool to address such disparities and uphold the collective welfare of Washingtonians. This Note focuses on fluoridation as a public health …
Neurodiversity In The Courtroom: Expanding Jury Service Accessibility Beyond Physical Disability, Samantha L. Mabe
Neurodiversity In The Courtroom: Expanding Jury Service Accessibility Beyond Physical Disability, Samantha L. Mabe
Seattle University Law Review
The Americans with Disabilities Act has required equal access to jury service for decades; however, efforts to accommodate jurors with disabilities have been slow to develop beyond some minor accommodations for physical disabilities. While neurodivergent people frequently struggle to navigate a world catered toward neurotypical people, jury service remains inaccessible for many neurodivergent people who need accommodations to attend trial and engage in jury deliberations. If courts and advocates do not consider how to develop accommodations to secure the service of neurodivergent jurors, they will miss out on the unique skillsets that neurodivergent people can bring to resolving disputes.
Disabled …
Sga 57 Senate 2025-10-31 Agenda, Niu Student Government Association Senate
Sga 57 Senate 2025-10-31 Agenda, Niu Student Government Association Senate
Student Government Association Archives
No abstract provided.
Sga 57 Senate 2025-10-31 Minutes, Niu Student Government Association Senate
Sga 57 Senate 2025-10-31 Minutes, Niu Student Government Association Senate
Student Government Association Archives
No abstract provided.
The Non-Coding Rna Journal Club: Highlights On Recent Papers-14, El Cheima Mhamedi, Florent Hubé, Suresh K. Alahari, Francisco J. Enguita, Barbara Pardini, Mark W. Feinberg, Laura Poliseno, Beshoy Armanios, Jing Jin, Xiao-Bo Zhong, Nikolaos Sideris, Salih Bayraktar, Leandro Castellano, Gaetano Santulli, Stanislovas S. Jankauskas, Will S. Plewa, Simon J. Conn, Ling Yang, Patrick K. Shiu, Abhishek Kaushik, Alexander Serganov, Gentile, Giuseppe Viglietto, Nicola Amodio, Tijana Mitić, Andrea Caporali
The Non-Coding Rna Journal Club: Highlights On Recent Papers-14, El Cheima Mhamedi, Florent Hubé, Suresh K. Alahari, Francisco J. Enguita, Barbara Pardini, Mark W. Feinberg, Laura Poliseno, Beshoy Armanios, Jing Jin, Xiao-Bo Zhong, Nikolaos Sideris, Salih Bayraktar, Leandro Castellano, Gaetano Santulli, Stanislovas S. Jankauskas, Will S. Plewa, Simon J. Conn, Ling Yang, Patrick K. Shiu, Abhishek Kaushik, Alexander Serganov, Gentile, Giuseppe Viglietto, Nicola Amodio, Tijana Mitić, Andrea Caporali
School of Graduate Studies Faculty Publications
The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...].
Urinary Vitamin D Binding Protein And Kidney Injury Molecule-1 Are Potent Predictors Of Acute Kidney Injury After Left Ventricular Assist Device Implantation, Shiyi Li, Iván Murrieta-Álvarez, Katherine V Nordick, Zachary Gray, Camila Hochman-Mendez, Alexis E Shafii, Kenneth K Liao, Carl P Walther, Nandan K Mondal
Urinary Vitamin D Binding Protein And Kidney Injury Molecule-1 Are Potent Predictors Of Acute Kidney Injury After Left Ventricular Assist Device Implantation, Shiyi Li, Iván Murrieta-Álvarez, Katherine V Nordick, Zachary Gray, Camila Hochman-Mendez, Alexis E Shafii, Kenneth K Liao, Carl P Walther, Nandan K Mondal
Faculty, Staff and Students Publications
Background/Objectives: Acute kidney injury (AKI) is a frequent and serious complication following left ventricular assist device (LVAD) implantation. This study aimed to predict AKI within 90 days post-LVAD by evaluating urinary levels of vitamin D binding protein (VDBP) and kidney injury molecule-1 (KIM-1).
Methods: We prospectively enrolled 29 advanced heart failure patients undergoing LVAD implantation and categorized them into four groups based on pre-LVAD kidney function and hemodynamic stability. Early-morning urine samples were collected 24 h before and 1 week after surgery. Urinary VDBP and KIM-1 levels, normalized to creatinine, were measured.
Results: Thirteen patients developed AKI …
Progressive Oxygenation Of The North Atlantic Subpolar Gyre, Jannes Koelling, Andrea J. Fassbender, Alison R. Gray, Gregory C. Johnson, Jonathan D. Sharp, Dustin Carroll
Progressive Oxygenation Of The North Atlantic Subpolar Gyre, Jannes Koelling, Andrea J. Fassbender, Alison R. Gray, Gregory C. Johnson, Jonathan D. Sharp, Dustin Carroll
Faculty Research, Scholarly, and Creative Activity
The subpolar North Atlantic (SPNA) is one of the few regions where the deep ocean is in direct contact with the atmosphere, making it a key location for interior ocean ventilation through gas exchange. We use a novel observation-based data product to analyze large-scale patterns of the air-sea flux of oxygen, finding a mean annual flux of 48.1 (Formula presented.) 14.6 Tmol (Formula presented.) from the atmosphere into the ocean integrated over the SPNA ((Formula presented.) N– (Formula presented.) N). An analysis of a fully-closed oxygen budget from the data-assimilative ECCO-Darwin ocean biogeochemistry model suggests that the net uptake is …
Women With Persistent Atrial Fibrillation Need More Than Pulmonary Vein Isolation: Personalised Extra-Pulmonary Vein Ablation Strategy Vs. Pulmonary Vein Isolation Alone In The Tailored-Af Trial, Isabel Deisenhofer, Daniel H Cooper, Et Al.
Women With Persistent Atrial Fibrillation Need More Than Pulmonary Vein Isolation: Personalised Extra-Pulmonary Vein Ablation Strategy Vs. Pulmonary Vein Isolation Alone In The Tailored-Af Trial, Isabel Deisenhofer, Daniel H Cooper, Et Al.
2020-Current year OA Pubs
AIMS: There is still conflicting evidence if women with persistent atrial fibrillation (AF) profit from a pulmonary vein isolation (PVI) plus strategy. We evaluated the efficacy of a spatio-temporal dispersion-targeted ablation strategy in women from the TAILORED-AF trial.
METHODS AND RESULTS: In TAILORED-AF, 370 patients were randomised to either a personalised, artificial intelligence (AI)-guided tailored ablation or to PVI-only. AF substrate mapping data and 12-month ablation outcomes were compared between women and men. Overall, 21% patients were female (70.4 ± 6.9 vs. 64.5 ± 8.5 years for men, P < 0.001). While spatio-temporal dispersion extent was similar between groups, left atrial low-voltage surface area (< 0.2 mV) was significantly larger in women (P < 0.01). In women, the single-procedure freedom from AF (76% vs. 50%, log-rank P < 0.001) and any atrial arrhythmia (56% vs. 38%, log-rank P < 0.05) were significantly superior to PVI alone with a tailored procedure. In the PVI-only group, the single-procedure freedom from AF (50% vs. 70%, log-rank P < 0.001) and any atrial arrhythmia (38% vs. 61%, log-rank P < 0.001) were significantly lower in women. After a tailored ablation, no significant differences were observed between women and men regarding freedom from AF (76% vs. 91%, log-rank P = 0.07) or any atrial arrhythmia (56% vs. 62%, log-rank P = 0.69) free survival.
CONCLUSION: Compared to men, PVI-only in women with persistent AF leads …
Model-Based Assessment Of Ocean Monitoring Temporal And Spatial Resolution Requirements For Acoustic Operations, William K. Stevens, Martin Siderius
Model-Based Assessment Of Ocean Monitoring Temporal And Spatial Resolution Requirements For Acoustic Operations, William K. Stevens, Martin Siderius
Electrical and Computer Engineering Faculty Publications and Presentations
Understanding present and future ocean conditions is essential for the effective planning and execution of a wide range of naval and commercial acoustic operations. The four-dimensional structure of temperature and salinity}from the ocean surface to the seabed}is a critical factor influencing acoustic transmission properties. Modern numerical ocean modeling systems consist of three primary components: ocean observations, a numerical forecasting model, and a data assimilation system. Of the tens of millions of global ocean observations assimilated daily, the majority derive from satellite-based surface measurements. In stark contrast, subsurface water column measurements number only in the thousands per day. This disparity highlights …
Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia Patients Have Dismal Outcomes Irrespective Of Allogeneic Hematopoietic Stem Cell Transplant: A Single-Center Experience, Gabriela Llaurador, Matthew Willis, Michele S Redell, M Monica Gramatges, Andrea N Marcogliese, Swati Naik, Robert Krance, Erin Doherty, Alexandra M Stevens
Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia Patients Have Dismal Outcomes Irrespective Of Allogeneic Hematopoietic Stem Cell Transplant: A Single-Center Experience, Gabriela Llaurador, Matthew Willis, Michele S Redell, M Monica Gramatges, Andrea N Marcogliese, Swati Naik, Robert Krance, Erin Doherty, Alexandra M Stevens
Faculty, Staff and Students Publications
Background: Pediatric non-Down Syndrome Acute Megakaryoblastic Leukemia (non-DS-AMKL) is a rare subtype of Acute Myeloid Leukemia (AML) arising from primitive megakaryocytes and is associated with poor outcomes. Given its high incidence of relapse, this subpopulation of children is frequently referred for allogeneic hematopoietic stem cell transplant (allo-HSCT) in first complete remission (CR1).
Objectives: The objective of this study was to describe the clinical outcomes of non-DS-AMKL pediatric patients in a large, single-institution cohort.
Methods: A retrospective review of the medical records of thirty-six patients diagnosed with non-DS-AMKL treated at Texas Children's Hospital from 2000 to 2022 was conducted.
Results: Twenty-nine …
The Role Of Pik3ca In Advanced And Metastatic Colorectal Cancer And The Therapeutic Potential And Efficacy Of Pik3ca Inhibitors, Humza Mallick, Marcus Yoakam, Samir Dalia
The Role Of Pik3ca In Advanced And Metastatic Colorectal Cancer And The Therapeutic Potential And Efficacy Of Pik3ca Inhibitors, Humza Mallick, Marcus Yoakam, Samir Dalia
Student Publications
Colorectal cancer (CRC) is one of the most prevalent malignancies globally and is the leading cause of cancer mortality worldwide. Advanced and metastatic CRC is associated with poor prognosis due to high rates of metastases and resistance to standard therapies. With the advent of next-generation sequencing, there has been increased interest in molecularly targeted treatments. One such molecular target is the PIK3CA gene, a key component of the phosphatidylinositol 3-kinase (PI3K) pathway, which has been linked to promoting tumor survival and proliferation in cancer cell populations. PIK3CA mutations are detected in approximately 10–20% of CRC cases. The presence of these …
Establishing A Framework Of Best Management Practices For Sustainable Water Quality: Integration Of Technology And Remote Sensing, Mason L. Marcantel
Establishing A Framework Of Best Management Practices For Sustainable Water Quality: Integration Of Technology And Remote Sensing, Mason L. Marcantel
LSU Master's Theses
Water quality security is a complex management issue that is constantly challenged by factors of seasonal variability in climate change, urban population growth, and agricultural intensification. These factors warrant the need for innovative technological adaptations to management practices that integrate remote monitoring, predictive modeling, and sustainable resource utilization. This study establishes a framework for sustainable water quality practices through the integration of remote sensing technology for urban wastewater treatment and agricultural irrigation systems. This dual-site research study explores seasonal water quality dynamics and technological interventions to create a more proactive approach to water quality security.
In the first study, water …
Understanding Michigan’S Reconnect Program Applicants, Alexander W. Bartik, Brad J. Hershbein, Brian Jacob, Kevin M. Stange, Bryan A. Stuart, Zhonghan Xie
Understanding Michigan’S Reconnect Program Applicants, Alexander W. Bartik, Brad J. Hershbein, Brian Jacob, Kevin M. Stange, Bryan A. Stuart, Zhonghan Xie
Reports
No abstract provided.
Resolving Slc6a1 Variable Expressivity With Deep Clinical Phenotyping And Drosophila Models, Kristy L Jay, Nikhita Gogate, Paige I Hall, Kimberly M Ezell, Jonathan C Andrews, Sharayu V Jangam, Hongling Pan, Kelvin Pham, Ryan German, Vanessa Gomez, Emily Jellinek-Russo, Eric A Storch, Brain Gene Registry Consortium, Undiagnosed Diseases Network, Shinya Yamamoto, Oguz Kanca, Hugo J Bellen, Herman A Dierick, Joy D Cogan, John A Phillips, Rizwan Hamid, Thomas Cassini, Lynette Rives, Sumit Pruthi, Hua-Chang Chen, Jennifer E Posey, Michael F Wangler
Resolving Slc6a1 Variable Expressivity With Deep Clinical Phenotyping And Drosophila Models, Kristy L Jay, Nikhita Gogate, Paige I Hall, Kimberly M Ezell, Jonathan C Andrews, Sharayu V Jangam, Hongling Pan, Kelvin Pham, Ryan German, Vanessa Gomez, Emily Jellinek-Russo, Eric A Storch, Brain Gene Registry Consortium, Undiagnosed Diseases Network, Shinya Yamamoto, Oguz Kanca, Hugo J Bellen, Herman A Dierick, Joy D Cogan, John A Phillips, Rizwan Hamid, Thomas Cassini, Lynette Rives, Sumit Pruthi, Hua-Chang Chen, Jennifer E Posey, Michael F Wangler
Faculty, Staff and Students Publications
Variants in SLC6A1 result in a rare neurodevelopmental disorder characterized by a variable clinical presentation of symptoms including developmental delay, epilepsy, motor dysfunction, and autism spectrum disorder. SLC6A1 haploinsufficiency has been confirmed as the predominant pathway of SLC6A1-related neurodevelopmental disorder (SLC6A1-NDD); however, the molecular mechanism underlying the variable clinical presentation remains unclear. Here, through work of the Undiagnosed Diseases Network, we identify an individual with an inherited p.A334S variant of uncertain significance. To resolve this variant and better understand the variable expressivity associated with SLC6A1, we assess the phenotypes of the proband in comparison with a cohort of 13 individuals …
Re: 3rd Quarter 2025 – Interim Site-Wide Surface Water Monitoring Data Report Silver Bow Creek Butte Area Npl Site, Butte Priority Soils Operable Unit Consent Decree-Civil Action No. Cv 89-039-Bu-She, Josh Bryson
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Exploration Psychology: Preparing Explorers More Effectively For Expeditions., Jon Rhodes
Exploration Psychology: Preparing Explorers More Effectively For Expeditions., Jon Rhodes
School of Psychology
Exploration environments expose individuals and teams to prolonged uncertainty, physical risk, and cognitive strain. Despite advances in expedition technology and logistics, psychological preparation for extreme environments remains comparatively underdeveloped. This presentation introduces the concept of exploration psychology as an applied framework for preparing individuals and teams to function effectively in high-risk and unpredictable expedition contexts. Drawing on research from performance psychology, stress physiology, and cognitive science, the talk outlines how psychological mechanisms underlying fear, attention, and decision-making influence behaviour in extreme environments. Fear responses involve rapid amygdala activation followed by potential top-down regulation through prefrontal cognitive appraisal, shaping behavioural responses …
Runx2 Cooperates With Srebp1 To Rewire Cancer Metabolism And Promote Aggressiveness, Emanuele Vitale, Mila Gugnoni, Veronica Manicardi, Silvia Muccioli, Federica Torricelli, Benedetta Donati, Simonetta Piana, Gloria Manzotti, Elisa Salviato, Francesca Reggiani, Cristian Ascione, Rebecca Vezzani, Moira Ragazzi, Mattia Forcato, Oriana Romano, Silvio Bicciato, Aaron Goldman, Marco Tigano, Alessia Ciarrocchi
Runx2 Cooperates With Srebp1 To Rewire Cancer Metabolism And Promote Aggressiveness, Emanuele Vitale, Mila Gugnoni, Veronica Manicardi, Silvia Muccioli, Federica Torricelli, Benedetta Donati, Simonetta Piana, Gloria Manzotti, Elisa Salviato, Francesca Reggiani, Cristian Ascione, Rebecca Vezzani, Moira Ragazzi, Mattia Forcato, Oriana Romano, Silvio Bicciato, Aaron Goldman, Marco Tigano, Alessia Ciarrocchi
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Embryonic Transcription Factors (TFs) are often reactivated in cancer, driving developmental gene programs that support phenotypic plasticity. Metabolic adaptation fuels this plasticity by supplying energy and molecular building blocks for growth. RUNX2, the master regulator of bone morphogenesis, is ectopically expressed in epithelial cancer, promoting metastasis through trans-differentiation processes like Epithelial-to-Mesenchymal Transition (EMT) and osteomimicry. By combining omics data with functional validation, we demonstrated that RUNX2 drives cancer cell metabolic rewiring by repressing mitochondrial respiration while promoting anabolic processes. We showed that RUNX2 upregulates key genes of lipid biosynthesis by regulating and cooperating with SREBP1. In vivo expression analysis in …
How Augmin Establishes The Angle Of The Microtubule Branch Site, Sophie M Travis, Jodi Kraus, Collin T Mcmanus, Kiana Golden, Rui Zhang, Sabine Petry
How Augmin Establishes The Angle Of The Microtubule Branch Site, Sophie M Travis, Jodi Kraus, Collin T Mcmanus, Kiana Golden, Rui Zhang, Sabine Petry
2020-Current year OA Pubs
How microtubules (MTs) are generated in the proper orientation is essential to understanding how the cytoskeleton organizes a cell and MT-dependent events such as cell division. In the spindle, most MTs are generated through the branching MT nucleation pathway. In this pathway, new MTs are nucleated from the side of existing MTs and oriented at a shallow angle by the branching factor augmin, ensuring that both MTs have the same polarity. Yet, how augmin binds MTs and sets the branch angle has remained unclear. Here, we report the cryo-electron microscopy structure of an augmin subcomplex on the MT. This structure …
"Breaking Barriers: First-Gen Experiences", Julian Melendez Miranda
"Breaking Barriers: First-Gen Experiences", Julian Melendez Miranda
First-Gen Voices: Creative and Critical Narratives on the First-Generation College Experience
Journey to college as a first-generation student, navigating challenges and self-doubt.
First Gen Voices, Jesus Arias
First Gen Voices, Jesus Arias
First-Gen Voices: Creative and Critical Narratives on the First-Generation College Experience
Looking back at my first semester, I’ve made some truly fond memories. Starting off with an amazing group of people in the program and going on our retreat helped me find a community I could rely on. This community has remained by my side, even during challenging times, and for that, I’ll always be grateful. Whether it was tackling escape rooms or being part of First Year Seminar, the first-gen community has shown itself to be incredibly strong and tightly connected.
The First Generation, Alberto Martinez
The First Generation, Alberto Martinez
First-Gen Voices: Creative and Critical Narratives on the First-Generation College Experience
My poem basically describes how I feel as a first-generation student is. Many of us including myself, felt as if we were alone, not knowing if we have someone by our side, but through our experience, we do share a common ground. First to go is a place where we all can share that and is a place where we do not have to be alone but have the support of those around us who can relate to how we feel.
Roots, Aolanni Jimenez-Gonzalez
Roots, Aolanni Jimenez-Gonzalez
First-Gen Voices: Creative and Critical Narratives on the First-Generation College Experience
This poem closely focuses on my experience and acceptance of my first-generation identity. Language is a symbol of my heritage from my family and how I carry hope and resilience as I navigate my everyday life. I want to depict my journey through language and how it serves as a powerful source to communicate with my loved ones and others. While appreciating the roots and strength of my family and striving to live out my dreams and be the first of many to come.