Digital Commons Network^™

Solid Dispersion Of 4-[(2r,3s,4s,5r)-3-(3,4-Difluoro-2-Methoxyphenyl) -4,5-Dimethyl-5-(Trifluoromethyl)Oxolane-2-Amido]Pyridine-2-Carboxamide, Msn Laboratories Private Limited, R&D Center, Srinivasan Thirumalai Rajan; Sagyam Rajeshwar Reddy; Rajashekar Kommera; Venkata Subbaiah Batchanaboina; Savarala Triveni

Defensive Publications Series

The present invention relates to a solid dispersion of 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-amido]pyridine-2-carboxamide

Anonymous Purchase Commitment With Optional Public Account Binding: Verifiable First-Hand Purchase Claims On A Public Ledger, Takuya Ogura

Defensive Publications Series

A method for letting readers, and AI agents acting for readers, distinguish real first-hand purchase accounts from fabricated ones without revealing buyer identity. Each paid purchase is recorded on a blockchain as a commitment computed as plain SHA-256(nonce || buyerId), so the buyer can open and verify their own record with a single hash on any machine, without the chain's SDK or the seller's cooperation; the identity was measured on chain to match an externally computed digest byte for byte. Separately, a buyer who chooses to speak publicly can attach a plaintext account handle to one purchase as a second, …

A Graph-Based Infrastructure Change Modeling System With Dependency-Aware Risk Propagation For Pre-Deployment Failure Prediction, Utkarsh Bhardwaj, Shivank Awasthi

Defensive Publications Series

Modern Continuous Integration and Continuous Deployment (CI/CD) systems rely predominantly on static analysis and deterministic rules, rendering them incapable of forecasting emergent risks arising from complex infrastructure interactions. This reactive approach frequently fails to prevent production incidents caused by non-obvious dependencies between code, configuration, and infrastructure. This paper proposes a novel Artificial Intelligence for IT Operations (AIOps) system that models cloud infrastructure as a topological dependency graph. We introduce the concept of a "Delta Graph" ($\Delta G$), which explicitly represents the structural and attribute changes between a currently deployed state ($t_0$) and a proposed state ($t_1$). By utilizing a Graph …

An Improved Process For The Preparation Of An Orexin Receptor Antagonist, Lee Pharma Limited

Defensive Publications Series

The present disclosure relates to (S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl) (5-methoxy-2-(2H-1,2,3-triazol-2-yl) phenyl) methanone hydrochloride, is represented by following structural formula (1).

The present disclosure relates to a process for the preparation of an intermediate of compound of formula (1), the intermediate is represented by following structural formula (2).

The present disclosure relates to a process for the preparation of an intermediate of compound of formula (1), the intermediate is represented by following structural formula (5).

The present disclosure relates to a process for the preparation of an intermediate of compound of formula (1), the intermediate is represented by following structural formula (6).

A Scientometric And Comparative Study Of Igg4-Related Disease Research By Rheumatologists And Stomatologists, Kailiu Wu

Articles in Press

No abstract provided.

Co-Infection With Herpes Simplex Virus Type 1 And Aggregatibacter Actinomycetemcomitans Disrupts Oral Epithelial Barrier Integrity And Enhances Viral Amplification Via P38 Mitogen-Activated Protein Kinase Activation - An In Vitro Study, Shan-Ling Hung

Articles in Press

No abstract provided.

Disney And Critical Global Citizenship: Border Politics And Linguistic Decolonization In The Lion Guard, Gordana Lazić

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

In this essay, I analyze the Disney television series The Lion Guard as a site of public pedagogy and argue that the show fosters a form of critical global citizenship among young viewers. It does this, I further maintain, in two primary ways: the progressive treatment of and careful attention to immigration and border politics, and disruption of the hegemony of the English language. Through age-appropriate plot development and dialogue, The Lion Guard actively participates in public pedagogy urging future policy and decision-makers to develop critical global consciousness.

Humanity, Ai, And The Pedagogy Of Vince Gilligan’S Pluribus, J. Scarlett Kingsley

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This review discusses the tv show Pluribus as a contemporary television narrative that functions as an allegory for artificial intelligence and its implications for human meaning-making. Centering on Carol Sturka, one of thirteen individuals immune to a alien global virus that merges humanity into a cooperative “Hive Mind”, the series explores tensions between autonomy and collective well-being in a “peaceful apocalypse.” The analysis argues that the Hive Mind reflects key concerns surrounding AI, including the production of knowledge without understanding, personalization without discernment, and efficiency that bypasses the struggle through which meaning is formed. Drawing on John Searle’s distinction between …

Ephemeral Secrets Runtime For Kubernetes Workloads, Ananya Verma, Raouf Khan

Defensive Publications Series

Ephemeral Secrets Runtime For Kubernetes Workloads

ABSTRACT

The present disclosure relates to a system for ephemeral secrets runtime in Kubernetes workloads which includes an ephemeral secrets runtime system configured to receive a request from a Kubernetes workload for accessing a protected downstream resource, collect Kubernetes-workload identity attributes and runtime trust signals associated with the Kubernetes workload, generate a unified trust context by aggregating the collected identity attributes and runtime trust signals, evaluate the unified trust context against authorization policies to determine credential issuance parameters, generate a short-lived credential based on the credential issuance parameters, cryptographically bind the short-lived credential to …

A Multi-Stage Low-Voltage Electromagnetic Compatibility (Emc) Filter Topology For Powertrain Inverters

Defensive Publications Series

A multi-stage low-voltage (LV) electromagnetic compatibility (EMC) filter topology independently suppresses common-mode (CM) and differential-mode (DM) high-frequency noise in automotive e-powertrain inverters. The circuit implements structural staging combined with damping resistors to enable frequency-specific noise attenuation. By partitioning the filter into three distinct DM stages and two distinct CM stages, the architecture allows precise, independent tuning across low, middle, and high-frequency spectrums without causing negative resonance or affecting adjacent bands.

Method And System For Subscription-Based Tokenization With Dynamic Payment Instrument Switching, Alok Roy

Defensive Publications Series

The present disclosure provides a payment network system configured to generate a subscription token representing a subscription-level payment identity for a recurring payment relationship between a customer and a merchant. A mapping engine stores a mapping that associates the subscription token with a merchant identifier, a customer mobile identifier, and a payment card credential. The subscription token is returned to the merchant system and stored as a recurring payment identifier. During a recurring payment transaction, a transaction resolution engine receives a transaction request including the subscription token and resolves the subscription token to an active payment card credential based on …

Advanced Control Method For Magnetic Bearings In High-Speed Shaft Systems

Defensive Publications Series

Active magnetic bearing (AMB) systems applied in high-speed turbomachinery and compressors are subject to severe internal and external dynamic forces that induce structural resonances and vibrations. Standard state-feedback approaches rely heavily on high plant model fidelity and require extensive calibration time, while remaining vulnerable to model-mismatch state disturbances caused by in-controller parameter uncertainties. This proposed solution discloses an advanced control method that integrates an Input Disturbance Observer (IDO) methodology with an Iterated Linear-Quadratic (ILQ) state-feedback controller. The framework dynamically estimates and counteracts external loads and model-mismatch discrepancies directly within the magnetic bearing force domain. This design eliminates the need for …

Profile Detection For Seat Adjustment, Anonymous

Defensive Publications Series

This invention fixes a memory seat issue that occurs when a key fob (or Phone As Key) is shared among users. Normally, the seat auto-adjusts to a saved position linked to the key fob, but if a different-sized person uses it, the seat still moves incorrectly, causing discomfort. The invention detects this occupant mismatch by using the driver facing camera and prevents unwanted repositioning.

Marine Recombinant L-Asparaginase-Moo3 Nanocomposite As An Ecofriendly Antifouling Paint Formula, Manal G. Mahmoud, Amany S. El Sharkawy, Laila A. Mohamed, Amany A. Elkashef, Mohamed Amer

Blue Economy

Marine biofouling poses significant economic and environmental challenges by increasing fuel consumption, accelerating material degradation, and facilitating the spread of invasive species. Environmentally benign antifouling technologies are therefore urgently needed following restrictions on conventional biocidal coatings. In this study, recombinant L-asparaginase derived from the marine bacterium Pseudomonas otitidis EGY-NIOF-A1 was immobilized onto molybdenum trioxide nanoparticles (MoO₃NPs) and evaluated as a novel eco-friendly antifouling coating additive.

The recombinant enzyme exhibited an activity of 19.9 U mL^-1 and a specific activity of 2.03 U mg^-1. Antimicrobial assays demonstrated inhibitory activity against selected pathogenic microorganisms, while hemolysis assays …

Cmsi Translations #36: The First Joint Underwater Patrol: Starting With The China-Russia "Joint Sea-2025" Exercise, Guan Hai

CMSI Translations

In August of this year (2025), deep within the waters of the Northwestern Pacific, an underwater patrol was reshaping the strategic landscape of the Asia-Pacific. The Russian submarine Volkhov and the Chinese Navy’s submarine Changcheng 210 came together in a joint formation for the first time, traversing the Sea of Japan and the East China Sea to complete a joint underwater patrol spanning more than 2,000 nautical miles.

The joint underwater patrol conducted by Chinese and Russian submarine formations represents a new form of joint maritime patrol for the two navies, following their joint surface ship patrols. This move not …

What If God Is Safer Than You Think?, Anna Bennett

The Main Thing Devotional

“O Lord, You have searched me and known me… You go before me and follow me. You place Your hand of blessing on my head,” Psalm 139:1,5, NLT.

Prioritising Safe Care For Noncommunicable Diseases: A Call To Action On World Patient Safety Day 2026, Subhash Kaushik

Indian Journal of Research in Homoeopathy

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Raman Spectroscopy Characterisation Of 5c Potency Of Homoeopathic Drugs Nux Vomica, Thuja Occidentalis And Nitricum Acidum, Alfonso Tramontana, Giuseppe Acri, Lucia Denaro, Massimo Mattozzi, Maria Antonietta D'Avanzo, Barbara Testagrossa

Indian Journal of Research in Homoeopathy

Background: The physicochemical characterisation of homoeopathic medicines remains a challenge. Raman spectroscopy is a promising tool for identifying structural modifications in the solvent matrix and specific vibrational ``fingerprints'' induced by the potentisation process. Objective: This study aimed to characterise three remedies (Nux vomica, Thuja occidentalis, and Nitricum acidum - 5C potencies) using Raman spectroscopy to identify specific vibrational markers and evaluate the technique's ability to differentiate between different preparations within a complex matrix. Materials and methods: The drugs were analysed as crushed granules (solid state) and after dissolution in betamethasone disodium phosphate (liquid state). Raman spectroscopy was …

Immunomodulatory Activity Of Bryonia Alba 6c And 30c In Sheep Red Blood Cell-Immunised Mice: Insights From Humoral And Delayed-Type Hypersensitivity Responses, Abanti Goswami, Narasimha Kumar Gv, Vara Prasad Saka, Suneel Prajapati, Bibaswan Biswas, Pankaj Gupta

Indian Journal of Research in Homoeopathy

Background: Malnutrition and infectious diseases compromise immune responses, increasing vulnerability to infections. The introduction of plant-derived immunomodulators, such as Bryonia alba (Bry. alba), is attracting attention due to their lower side effects compared with chemical drugs. In Homoeopathy, Bry. alba has long been utilised to treat a wide range of illnesses, including viral infections, and is recognised for its immunomodulatory properties. Objectives: To evaluate the immunomodulatory effects of Bry. alba 6C and 30C potencies on humoral and delayed-type hypersensitivity (DTH) in sheep red blood cell (SRBC)-immunised BALB/c mice. Materials and methods: Fifty BALB/c mice were divided into five …

A Retrospective Descriptive Profile Of Cancer Patients Seeking Homoeopathic Care In A Semi-Rural South African Setting, Radmila Razlog

Indian Journal of Research in Homoeopathy

Background: Patient profiling renders valuable information about the population's healthcare-seeking behaviours, critical for effective patient management. Khula Natural Health Centre (KNHC) in South Africa provides healthcare to rural communities, within the scope of Homoeopathy. Objective: The study aimed to create a preliminary cancer patient profile of KNHC from April 2017 to August 2024. Method: This retrospective study adopted a descriptive, exploratory design. Anonymised patient data was extracted from the KNHC database. Data that met the inclusion criteria were descriptively analysed to summarise and describe the dataset. Results: Forty-six participants' data, presenting a range of cancers, consulted at KNHC for homoeopathic …

Common Symptoms In Homoeopathy. Are They Really Useless? Results From An Empirical Assessment Of Best Cases Data From A Bayesian Perspective: An Observational Study, José Enrique Eizayaga, Lex L. Rutten

Indian Journal of Research in Homoeopathy

Background: In seeking the homoeopathic medicine that best fits their case, homoeopaths traditionally yield greater value to the most peculiar symptoms, while dismissing those they believe to be common, according to the number of medicines found in repertories' rubrics. Objectives: To assess the validity of the following homoeopathic usual practice notions: common symptoms are useless and prescription should rely on peculiar ones. Methods: Empirical data from the Best Chronic Homeopathic Cases (BCHC) and the COVID-19 cases collection databases were analysed by using a Bayesian approach. Symptoms' prevalence and likelihood ratio (LR) were calculated. Results from three very common symptoms in …

Actinic Lichen Planus Treated With An Individualised Homoeopathic Approach: A Case Report, Aloke Kumar Ghosh, Shilpa Mandal, Ritika Bose, Sumanta Kamila

Indian Journal of Research in Homoeopathy

Introduction: Lichen planus (LP) is an idiopathic chronic inflammatory disorder of the skin and mucous membranes. Actinic lichen planus is a rare photosensitive variant that affects sun-exposed areas and may significantly impair quality of life due to its disfiguring nature. Conventional management primarily involves topical or systemic corticosteroids, which are associated with adverse effects and frequent relapses. Scientific literature on homoeopathic management of actinic LP remains limited. Case summary: A 61-year-old woman presented with pruritic, purple-black plaques over the forehead and was clinically diagnosed with actinic LP persisting for the last five months. Causticum in LM potency was prescribed after …

Treatment Of Exfoliative Dermatitis Using Homoeopathic Dilution Graphites In Lm Potency: A Case Report, K. C. Muraleedharan, Kanishka Gandhi

Indian Journal of Research in Homoeopathy

Introduction: Exfoliative dermatitis is a severe form of skin irritability that causes significant erythema and/or scaling. Most of the time, it is a secondary process, and numerous factors could contribute to the development of this widespread skin condition. Psoriasis is the most prevalent reason for exfoliative dermatitis among all dermatologic disorders. Case Summary: A 49-year-old male presented with skin exfoliation with itching, burning and pain on the whole body for 2 weeks associated with serous discharge from lesions at the back and axillae secondary to psoriasis. A single homoeopathic medication Graphites in LM potencies over two months was prescribed that …

Conventional Medicine, Industry, And Homoeopathy: Between Scientific Paradigms, Economic Interests, And Structural Prejudices, Jozelio F. De Carvalho

Indian Journal of Research in Homoeopathy

This article discusses the key epistemological, economic, and structural factors that contribute to the marginalisation of Homoeopathy within contemporary biomedical science. This integrates information from scientific literature, policy discussions, and historical sources addressing evidence hierarchies, trial design, funding patterns, and institutional determinants of scientific legitimacy in medicine. Examples from systematic reviews, randomised controlled trials, pragmatic studies, and N-of-1 research frameworks are considered to contextualise how methodological models may favour or disadvantage specific therapeutic paradigms. Homoeopathy remains a contested field not only due to conflicting results in clinical studies, but also because classical randomised trial designs may fail to adequately capture …

Homoeopathic Management Of Primary Venous Leg Ulcer With Apis Mellifica: A Case Report, Tejashri V. Thakare, Alfisha T. Shaikh

Indian Journal of Research in Homoeopathy

Introduction: Venous leg ulcers are common chronic lower-limb ulcers, primarily resulting from chronic venous insufficiency, venous hypertension, and impaired venous return. They are associated with oedema, pain, skin changes, restricted mobility, delayed healing, and significant morbidity. Despite conventional approaches such as compression therapy, wound dressings, antibiotics, and surgical interventions, healing may be prolonged, and recurrence is common. Case Summary: A 76-year-old male presented with a three-month history of a non-healing ulcer of the left lower limb, accompanied by oedema, pain, swelling, and difficulty in walking. Based on individualisation of symptoms, Apis mellifica 30C was prescribed. Significant symptomatic relief was observed …

Research Highlights, Gandham Kumuda, Monika Chandyoke

Indian Journal of Research in Homoeopathy

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Encouraging Innovation Through Intellectual Property Rights In Homoeopathy, Parth Aphale, Shashank Dokania, Himanshu Shekhar

Indian Journal of Research in Homoeopathy

NA

Indian Standard For Safe Handling Of Biotherapeutic Products Used In Homoeopathy: Guidelines, Kumar Vivekanand, Indra Gaurav Saxena, Divya Taneja, Shailendra K. Saxena, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Biotherapeutic products used in Homoeopathy are derived from biological sources of human, animal, microbial and other origins and include pathological and non-pathological preparations such as nosodes and sarcodes. Owing to the biological nature of these materials, their safe handling, preparation, storage, testing and documentation require systematic controls to protect personnel, the public and the environment. The Indian Standard `IS 19901:2026, Safe Handling of Biotherapeutic Products Used in Homoeopathy — Guidelines', provides a comprehensive framework for risk assessment, biosafety classification, containment, determination of first safe dilution (FSD), safety and efficacy evaluation, quality assurance, formulation, dispensing and documentation. The standard also establishes …

Evidence-Based Interventions For Suicide Prevention, Deepthi Gilla

Indian Journal of Research in Homoeopathy

NA

Vaccinosis And Its Cure By Thuja With Remarks On Homoeoprophylaxis By Dr J. Compton Burnett, Rahul Yadav, J. P. Tripathi

Indian Journal of Research in Homoeopathy

NA