Digital Commons Network^™

The Molecular Mechanisms Underlying The Cancer Killing Effect Of Interleukin-24, Leah Eshanie Persaud

Dissertations, Theses, and Capstone Projects

Interleukin-24 (IL-24) is an immunomodulatory cytokine that also displays specific anti-tumor effects across many cancer cell types. The tumor suppressor activities of IL-24 include inhibition of angiogenesis, metastasis, toxic autophagy, cancer-specific apoptosis, and sensitization to traditional cancer treatments like chemotherapy and radiation. Overexpression of IL-24 can selectively induce apoptosis in various cancer cells while having no adverse effects on normal cells. Due to this favorable killing effect, IL-24 is currently in phase II clinical trials. There is accumulating evidence that IL-24’s anti-cancer activity is primarily through the endoplasmic reticulum (ER) stress pathway but other pathways leading to cell death are …

Preparation Of Enantioenriched Alkyltin Species And Their Application In Stereospecific Transformations, Glenn O. Ralph

Dissertations, Theses, and Capstone Projects

Organometallic reagents containing the tin-carbon bond are used extensively in modern synthetic chemistry for the formation of new bonds to carbon. Over recent decades, transition metal catalyzed cross coupling reactions between two C(sp²) centers have been widely developed. However, the introduction of a C(sp³) center complicates the catalytic cycle, and opens unproductive chemical pathways which lead to isomerization, elimination, and racemization. Our lab has developed a modified-Stille reaction to combat the deleterious effects of β-hydride elimination. Our protocol enables unactivated 2° alkyl organotin nucleophiles to undergo efficient cross coupling reactions with C(sp²) electrophiles, avoiding …

Essays In Health Economics, Chiao-Han Lin

Dissertations, Theses, and Capstone Projects

This dissertation consists of three essays that examine health care and behavioral issues among young adults in the United States.

Chapter 1 Health Care Issues in the United States

This chapter provides an overview of health care issues in the United States. There are three major problems: high cost of health care, gaps in access, and inadequate health levels. The cost and growth of health care at a rapid rate may due to the complex nature of the U.S. health care system and consumer-driven technology improvement. As health care costs soar, many individuals have been priced out of the health …

Desde El Margen: Teatro Alterno Y Comunidades Hispanas De Nueva York, 1997–2017, Pablo D. García Gámez

Dissertations, Theses, and Capstone Projects

Esta disertación analiza ocho textos de los autores Tere Martínez, Jorge Merced, Marco Antonio Rodríguez, Eva Cristina Vásquez y cuatro performances en la calle. La misma explora las relaciones entre los cuatro dramaturgos y las comunidades hispanas de Nueva York. Indaga en el proceso de cómo la memoria de estas comunidades se refleja en un repertorio teatral. Por otro lado, revisa la organización del performance cultural en las comunidades.

La hipótesis de esta investigación es que en el teatro hispano alterno hay obras que son reflejo y reflexión sobre los grupos periféricos y que el performance es una herramienta social. …

Captives Of A New Alcatraz: The New York City Department Of Correction From 1954 To 1990, Jarrod Shanahan

Dissertations, Theses, and Capstone Projects

This dissertation examines the New York City Department of Correction (DOC) from 1954 to 1990—a period that began with an audacious program, led by progressive penologist and DOC Commissioner Anna M. Kross, to replace “custodial” prisoner warehousing with a rehabilitative model directed by civilian experts. As part of this plan the political legitimacy, executive strength, and most importantly, the institutional capacity of DOC were expanded, while the department’s plant facilities were increasingly concentrated on Rikers Island. The previously remote penal island was connected by bridge to mainland Queens amid plans for dazzling new jails and a university-affiliated research institute, to …

Queer Pregnancy In Shakespeare's Plays, Alicia Page Andrzejewski

Dissertations, Theses, and Capstone Projects

Bringing together queer and feminist theory, this dissertation examines Shakespeare’s representations of pregnancy divorced from their promised duration and promised end, revealing that the pregnant body is not wholly symbolic of futurity, chastity, or even heterosexual desire. In queer readings of Shakespeare’s plays and in the methodological debates that inform them, the pregnant body has been conspicuously absent, despite being often subsumed into definitions of heteronormativity and procreative reproduction. In feminist work on Shakespeare’s pregnant characters, scholars largely conflate pregnancy with maternity instead of considering the ways in which these women might engage in non-heterosexual forms of intimacy and eroticism. …

Topological Insulating States In Photonics And Acoustics, Xiang Ni

Dissertations, Theses, and Capstone Projects

Recent surge of interest in topological insulators, insulating in their interior but conducting at the surfaces or interfaces of different domains, has led to the discovery of a variety of new topological states, and their topological invariants are characterized by numerous approaches in the category of topological band theory. The common features shared by topological insulators include, the topological phase transition occurs if the bulk bandgap is formed due to the symmetries reduction, the topological invariants exist characterizing the global properties of the material and inherently robust to disorder and continuous perturbations irrespective of the local details. Most importantly, these …

Empirical Analysis Of China’S Exchange Rate And Macroeconomic Policy, Jia Ji

Dissertations, Theses, and Capstone Projects

This dissertation examines the effects of exchange rate and macroeconomic policy in China. It consists of three chapters. Chapter 1 explores the dynamics of monetary transmission mechanism. As China’s domestic financial markets deepen and develop further toward a market-based system, the country’s monetary policy transmission should continue to improve in the sense that the policy instrument’s influence on economic conditions increases in magnitude and stabilized across time. Using a short-term key interest rate as a standard monetary policy tool and time-varying parameter techniques, this study empirically demonstrates that China’s monetary policy framework is in the midst of transitioning to a …

Training As Restructuring: Cases From Entry-Level Healthcare And Manufacturing Workforce Training In Eastern Connecticut, Shelley Buchbinder

Dissertations, Theses, and Capstone Projects

Since the 1980s, capital mobility and state restructuring have increased precarity in older industrial regions, such as eastern Connecticut (CT). These changes reconfigured labor markets, changing the work available, including the types, conditions, and skills required. Greater responsibility devolved onto poor and working-class people to navigate a labor market with insufficient living-wage work with 42.4% of jobs pay under $15/hour (Tung, Lathrop, & Sonn, 2015). Entry-level healthcare and manufacturing are two avenues for sub-baccalaureate, living-wage employment. Employment and Training (E&T) prepares people for entry-level jobs; it is a politically popular response to restructurings (Lafer, 2002; Laney et al., 2013). How …

A Novel Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Synapse Development, Hao Wu

Dissertations, Theses, and Capstone Projects

Cytoskeleton based active transport with motor proteins is essential for mRNA localization and local protein translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased screen for interaction between mRNA binding proteins (RBP) and motor proteins, we identified protein interacting with APP tail 1 (PAT1) as a potential direct adapter between the β-actin mRNA Zipcode-binding protein 1 (ZBP1) and Kinesin-1 motor complex.

Mouse PAT1 is similar to the Kinesin Light Chain (KLC) in amino acid sequence and binds directly to KLC. High-resolution images from structured illumination microscopy (SIM) indicates that synaptic stimulation …

A Purely Defeasible Argumentation Framework, Zimi Li

Dissertations, Theses, and Capstone Projects

Argumentation theory is concerned with the way that intelligent agents discuss whether some statement holds. It is a claim-based theory that is widely used in many areas, such as law, linguistics and computer science. In the past few years, formal argumentation frameworks have been heavily studied and applications have been proposed in fields such as natural language processing, the semantic web and multi-agent systems. Studying argumentation provides results which help in developing tools and applications in these areas. Argumentation is interesting as a logic-based approach to deal with inconsistent information. Arguments are constructed using a process like logical inference, with …

Adorno And The Language Of The Intellectual In Exile, Ana Baert

Dissertations, Theses, and Capstone Projects

Adorno’s experience as an exile influenced his two works Dialectic of Enlightenment: Philosophical Fragments (1944) and Minima Moralia: Reflections from a Damaged Life (1951). These works embody the adversity Adorno wrestled with in his personal life and voice a quasi-indignant resignation to the notion of displacement as a natural yet mutilated human condition. I will analyze Dialectic of Enlightenment through the subjective, experiential lens of Minima Moralia thereby revealing the personal allusions to Adorno himself in his analysis of Odysseus as the prototypical bourgeois.

This thesis explores a biographical approach of the man who was known for his viscero-critical voice. …

Racial Becoming: How Agentic (Self-Initiated) Encounter Events Inform Racial Identity Refinement, Devin A. Heyward

Dissertations, Theses, and Capstone Projects

Racial identity literature has typically focused on identity formation through a series of stages. It also has centered how the experience of negative encounter events informs racial identity formation. With the advent of new genealogical and genomic technology, it is imperative to expand the focus of identity literatures to include encounter events, which participants elect to experience (i.e. self-initiated or agentic encounter events). By using this frame, identity processes become fluid and informed by individual life experiences. In the context of this study, direct to consumer genetic ancestry tests (DTC-GAT) are operationalized as a self-initiated encounter event. Participants were …

Divided Loyalties: Family And Consent To Marriage In Late Middle English Literature, 1300–1500, Jennifer R. Alberghini

Dissertations, Theses, and Capstone Projects

Studies of marriage and family can help us learn how medieval women lived. This dissertation focuses on “consent theory,” which explains the medieval definition of marriage. According to the Church, a marriage was made valid by the couple’s consent, not outside pressures. This theory, as we might expect, conflicted with practice: children—daughters especially—were expected to be obedient to their parents and marry approved partners.

Medieval England’s legal system came down on both sides of the issue. Rape accusations were made by parents who disapproved of their daughter’s choices, and court cases evaluated the validity of a marriage made without parental …

Embodied Nostalgia: Early Twentieth Century Social Dance And U.S. Musical Theatre, Phoebe Rumsey

Dissertations, Theses, and Capstone Projects

In this dissertation, I claim the collective emotional connections and historical explorations characteristic of musical theatre constitute a nostalgic impulse dramaturgically inherent in the form. In my intervention in the link between nostalgia and musical theatre, I look to an area underrepresented in musical theatre scholarship: social dance. Through case studies that focus specifically on how social dance in musical theatre brings forth the dancer on stage as a site of embodied history, cultural memory, and nostalgia, I ask what social dance is doing in musical theatre and how the dancing body functions as a catalyst for nostalgic thinking for …

Who Needs Blame?: Answerability Without Expressed Blame, Sarah Gokhale

Dissertations, Theses, and Capstone Projects

This dissertation argues that we can hold other agents morally responsible without expressing blame and, more strongly, that doing so is preferable. I first argue that blame is fundamentally retributive, and that blame’s retributive foundation is incipiently present even in civilized guises. As such, even though some forms of expressed blame are quite civilized, expressed blame always involves a risk of emotional damage, entrenchment, and escalation. To make things worse, I argue that anger is an exacerbating feature of blame’s retributive foundation. I then argue that, generally speaking, cases of public blame involve higher stakes than cases of private judgments …

Mindfulness In Medicine: Modified Mindfulness-Based Stress Reduction (Mbsr) Program Among Future Doctors, Virtue Sankoh

Dissertations, Theses, and Capstone Projects

Medical trainees are at particular risk for stress-related illness, including mental health problems such as suicidal ideation, substance abuse, and mood disorders. A vast literature on mindfulness-based stress reduction (MBSR), consisting of mindfulness education and structured meditative practices, has consistently demonstrated that MBSR and related mindfulness-based interventions improve mental and physical health, as well as one’s overall sense of well-being. Moreover, theorists and researchers have begun to suggest further that mindfulness plays a particular role in social cognition, or social-emotional learning. Medical schools have long been interested in ways to improve the “soft skills” related to interpersonal connectedness that are …

Presidential Power: Assessing The Unitary Executive As The Strongest Determinant Of Presidential Success, Maxwell J. Fuerderer

Dissertations, Theses, and Capstone Projects

The Unitary Executive Theory, which implies that the president should have plenary authority over executive branch functions, and is the sole arbiter of executive power, can be attributed to increasing the powers of the presidency and overall making a president more successful in his policy endeavors. I have concentrated my research to contextualize different variables for presidential success, including prior experience, bureaucratic loyalty, historical context, and, most importantly, the unitary executive. I apply these determinants to two case studies to determine which are most effective. Using the examples of Andrew Jackson and Jimmy Carter, I show how their contrasting uses …

What Is The Relationship Among Team Psychological Safety, Nursing Agency, And Rapid Response System Activation?, Grace Mingsum Ng

Dissertations, Theses, and Capstone Projects

When patients show signs of clinical deterioration, nurses should activate the rapid response system (RRS) to summon specialized help to the bedside. Failure or delay to activate the RRS is associated with increased length of stay and increased mortality. Currently, nurses only activate the RRS 21-57% of the time. Nurses’ fear of criticism for making the wrong call has been identified as a reason or avoiding or delaying activation. Currently, only limited individual level factors affecting nurse RRS activation has been identified, but team-level barriers or facilitators or nurse RRS activation has not been systematically studied. A cross-sectional study was …

Broadway Bodies: Casting, Stigma, And Difference In Broadway Musicals Since "A Chorus Line" (1975), Ryan Donovan

Dissertations, Theses, and Capstone Projects

This dissertation explores how embodied identities facing social stigmatization are represented in Broadway musicals and provides histories of casting specific kinds of embodied difference. Broadway Bodies: Casting, Stigma, and Difference in Broadway Musicals since “A Chorus Line” considers the politics of representation and makes clear that casting is always a political act, situated within a power structure favoring certain bodies. Previous scholarship on casting largely centers on race and ethnicity as the central issues; this research reframes the study of casting to focus on bodies, inclusive of race and ethnicity but especially relative to ability, gender, sexuality, and size. Though …

Cosmopolitan Democracy: Re-Evaluation Of Globalization And World Economic System, Muhammad Dalhatu

Dissertations, Theses, and Capstone Projects

This thesis examines cosmopolitan democracy theory as a method of addressing the problems of globalization. I begin by introducing the concept of “cosmopolitan democracy.” I then proceed to discuss contemporary political climate and its relation to critiques of globalization. Finally, I conclude by examining the elaborations of cosmopolitan democracy by various theorists as a way of addressing these problems. Chapter 1 introduces the work of David Held who introduced the concept in his book, Cosmopolitan Democracy and the Global Order: Reflections on the 20^th Anniversary of Kant’s “Perpetual Peace.” Cosmopolitan democracy refers to global governance through democratic theory. Held …

Losing Louisiana: Race, Techno-Science, And The Disappearing Geographies Of The Lower Mississippi River Delta, Monica Patrice Barra

Dissertations, Theses, and Capstone Projects

Based on eighteen months of ethnographic and historical research in southeast coastal Louisiana (USA), this dissertation explores the racial histories, engineering and scientific practices, and geophysical processes that have shaped land loss and coastal restoration in the lower Mississippi River Delta. Rather than treating land loss simply as a natural process or matter of environmental restoration, this ethnography examines its cultural, material, and political dimensions, especially for communities of color that have already experienced long histories of loss — of property, livelihood, and political rights. A focus on the geophysical transformations of the river - dictating land growth, sinking, and …

The Crusader And The Dictator: An Exploration Of Ideology And Neurodivergence In Contemporary Technology Practice, David J. Williams

Dissertations, Theses, and Capstone Projects

A common theme in public discourse is the recognition that technology in general, and digital technology specifically, has an enormous impact on the everyday lives of people from all walks of modern life, in almost every corner of the globe. This thesis interrogates the connection between neurodivergence—the presence of neurological variations considered outside the cognitive norm— and individualistic ideology within the information technology industries. Through the biographies, substantial record of activities, public statements, and writings surrounding two influential figures in the contemporary practice of computer science, Richard Stallman and Linus Torvalds, it conducts an investigation into this convergence and its …

African-American Christian Female Missionaries In Nyasaland, Congo, And Liberia: Perpetuation And Resistance At The Intersections Of Blackness, Gender, Disability, And Christianity, Karen Yvette Dace

Doctoral Dissertations

Events are taking place in the United States today regarding blackness, gender, disability, and Christianity, and the perceived place of those with black and brown bodies. Current efforts have focused on blackness and gender, blackness and disability, gender and disability, and disability and Christianity; but there has not been concerted efforts focusing on the historical intersections of blackness, gender, disability, and Christianity and how these intersections help in understanding the contemporary black social movement and the climate in which we now live.

The purpose of this qualitative study sought to understand the narratives of Christian mission agencies and how African-American …

Tyrrhenian Central Italy: Holocene Population And Landscape Ecology, Simon Stoddart, J Woodbridge, Alessio Palmisano, Anna Maria Mercuri, Scott Andrew Mensing, Daniele Colombaroli, Laura Sadori, Donatella Magri, Rita F Di, Marco Giardini, Lippi M Mariotti, Carlo Montanari, Cristina Bellini, Assunta Florenzano, Paola Torri, Andrew Bevan, Stephen Shennan, Ralph Fyfe, C. Neil Roberts

School of Geography, Earth and Environmental Sciences

No abstract provided.

Humans Take Control Of Fire-Driven Diversity Changes In Mediterranean Iberia’S Vegetation During The Mid–Late Holocene, Simon E. Connor, Boris Vannière, Daniele Colombaroli, R. Scott Anderson, José S. Carrión, Ana Ejarque, Romera G Gil, Penélope González-Sampériz, Dana Hoefer, César Morales-Molino, Jordi Revelles, Heike Schneider, Der Knaap Wo Van, Leeuwen Jfn Van, Jessie Woodbridge

School of Geography, Earth and Environmental Sciences

No abstract provided.

Sediment Microbial Assemblage Structure Is Modified By Marine Polychaete Gut Passage, Harriet Dale, Martin Solan, Phyllis Lam, Michael Cunliffe

School of Biological and Marine Sciences

No abstract provided.

Sensitive Individuals Are More Creative, D Bridges, He Schendan

School of Psychology

Individual differences in cognition, affect, and personality have been explored extensively as factors in creativity, but pinpointing the exact factors has remained elusive. This review proposes that a major gap has been lack of research on the relation between creativity and temperament, which captures the biologically-based core of personality, especially studies on sensitive temperament. Sensitivity has been associated with creativity anecdotally and in early work but rarely investigated recently, particularly using recent more precise definitions of sensitivity and state-of-the-art sensitivity and creativity assessments, nor has the relationship between creativity and cognitive processes that should reflect sensitive neural processing been investigated. …

Finding And Using Tests And Instruments For Research, Randy L. Miller

Faculty Publications and Presentations

This handout talks about finding and using tests, measurements and other instruments for research. It discusses Mental Measurements Yearbook which offers commercially available instruments. It also shows ways to find “free” instruments that are reliable and valid as well as the articles describing the development and validation of these measures. A webinar based on this handout is available at https://watch.liberty.edu/media/t/1_23mxx0kj

Writing Workshops’ Impact On Third-Grade Students’ Writing Achievements And English Teachers’ Perceptions About Using Writing Workshops To Teach Writing In An Elementary Public School, Safeya Othman Abdulla Bin Mahri Alkatheeri

Theses

The present study examines the impact of writing workshops on third-grade students’ writing achievements and English teachers’ perceptions about the use of writing workshops to teach writing in an elementary public school in Al Ain, UAE. This study also addresses the challenges that English teachers encounter when implementing writing workshops in writing classes. A mixed-method design was employed to answer the three main research questions of the study. Initially, the quantitative data were collected through the pre-post writing test which was administered to third-grade students (N=83). Subsequently, the qualitative data in the form of the semi-structured interviews were collected from …