Digital Commons Network^™

Comparison Of Antimicrobial Agents Ozonated Olive Oil And Chlorhexidine Gluconate - An In Vitro Study, Amelia David

Loma Linda University Electronic Theses, Dissertations & Projects

Aim: This study was aimed to compare the antibacterial effect of a commercially available OzOO with CHX 0.12% oral rinse solution against periodontal pathogens F. alocis, Aa, S. mitis, and S. mutans using a disk diffusion method.

Materials and Methods:

The antimicrobial agents OzOO and 0.12% CHX were impregnated onto sterile discs and placed onto bacterial cultures of F.alocis, Aa, S.mutans, and S.mitis to evaluate their antimicrobial activity by the disk diffusion susceptibility method. The bacterial growth inhibition zone surrounding each disc was measured in millimeters of diameter with calipers to assess the antimicrobial activity of each agent. …

Complications Associated With Mandibular Fixed Complete Arch Prostheses Based On Implant Distribution, Shivani Karre

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The objective of this study is to compare incidence and type of complications associated with mandibular implant supported fixed complete arch prostheses based on implant distribution. Material and Methods: Patient Selection: The retrospective study included data collected from axiUm CE Version 6.05.01.2007 from year July 2007 to July 2018 for all patients treated with mandibular implant supported fixed complete arch prostheses (MISFCPs) at Loma Linda University School of Dentistry (LLUSD). One hundred and twenty seven patient’s charts were reviewed to document implant distribution and incidences of complications associated with each implant distribution groups on MISFCPs. Complications like screw …

Accuracy Of Intraoral Scanners With Different Total Occlusal Convergence Angles: An In-Vitro Study, Brittany M. Pang

Loma Linda University Electronic Theses, Dissertations & Projects

Digital intraoral imaging has become more utilized in contemporary dental practice. This is performed using an intraoral scanner and it can be used as an alternative to making conventional impressions when indicated. This technology has many advantages, such as decreasing the number of appointments by eliminating traditional techniques, along with a reduction of laboratory time and improved patient comfort. The accuracy of intraoral scanners is currently being assessed in various aspects. To our knowledge, no study has yet addressed the accuracy of intraoral scanners in regards to total occlusal convergence (TOC) of complete coverage of anterior and posterior preparations in …

Novel Pharmacological Therapy In Type 2 Diabetes Mellitus With Established Cardiovascular Disease: Current Evidence, Leonardo Pozo, Fatimah Bello, Andres Suarez, Francisco E. Ochoa-Martinez, Yamely Mendez, Chelsea H. Chang, Salim Surani

School of Medicine Publications

Cardiovascular diseases (CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus (T2DM) suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration (FDA) established new expectations for the evaluation of new …

Minocycline Inhibits Pdgf-Bb-Induced Human Aortic Smooth Muscle Cell Proliferation And Migration By Reversing Mir-221- And -222-Mediated Reck Suppression, Yusuke Higashi, Srinivas Mummidi, Sergiy Sukhanov, Tadashi Yoshida, Makoto Noda, Patrice Delafontaine, Bysani Chandrasekar

School of Medicine Publications

Minocycline, a tetracycline antibiotic, is known to exert vasculoprotective effects independent of its anti-bacterial properties; however the underlying molecular mechanisms are not completely understood. Reversion Inducing Cysteine Rich Protein with Kazal Motifs (RECK) is a cell surface expressed, membrane anchored protein, and its overexpression inhibits cancer cell migration. We hypothesized that minocycline inhibits platelet-derived growth factor (PDGF)-induced human aortic smooth muscle cell (SMC) proliferation and migration via RECK upregulation. Our data show that the BB homodimer of recombinant PDGF (PDGF-BB) induced SMC migration and proliferation, effects significantly blunted by pre-treatment with minocycline. Further investigations revealed that PDGF-BB induced PI3K-dependent AKT …

Impact Of A Formal Patient Safety And Quality Improvement Curriculum: A Prospective, Controlled Trial, Nausheen Jamal, Sarah N. Bowe, Michael J. Brenner, Karthik Balakrishnan, John P. Bent

School of Medicine Publications

Objective

To assess the impact of implementing a dedicated Patient Safety and Quality Improvement (PSQI) curriculum for otolaryngology residents.

Methods

Residents in two otolaryngology residency programs were recruited to participate in the study. Residents at institution A (intervention group) participated in a formal, newly developed, year-long PSQI curriculum. Residents at institution B (control group) participated in traditional, morbidity, and mortality conference-based PSQI education, with no formal curriculum in place. Curriculum participants completed anonymous surveys to assess learner satisfaction. Validated instruments were administered to assess for changes in resident confidence in the ability to develop PSQI projects, their attitudes toward patient …

Minocycline Inhibits Pdgf-Bb-Induced Human Aortic Smooth Muscle Cell Proliferation And Migration By Reversing Mir-221- And -222-Mediated Reck Suppression, Yusuke Higashi, Srinivas Mummidi, Sergiy Sukhanov, Tadashi Yoshida, Makoto Noda, Patrice Delafontaine, Bysani Chandrasekar

School of Medicine Publications

Minocycline, a tetracycline antibiotic, is known to exert vasculoprotective effects independent of its anti-bacterial properties; however the underlying molecular mechanisms are not completely understood. Reversion Inducing Cysteine Rich Protein with Kazal Motifs (RECK) is a cell surface expressed, membrane anchored protein, and its overexpression inhibits cancer cell migration. We hypothesized that minocycline inhibits platelet-derived growth factor (PDGF)-induced human aortic smooth muscle cell (SMC) proliferation and migration via RECK upregulation. Our data show that the BB homodimer of recombinant PDGF (PDGF-BB) induced SMC migration and proliferation, effects significantly blunted by pre-treatment with minocycline. Further investigations revealed that PDGF-BB induced PI3K-dependent AKT …

Use Of Gabapentin In The Treatment Of Substance Use And Psychiatric Disorders: A Systematic Review, Saeed Ahmed, Ramya Bachu, Vijaya P. Kotapati, Mahwish Adnan, Rizwan A. Ahmed, Umer Farooq, Hina Saeed, Ali M. Khan, Aarij Zubair, Iqra Qamar, Gulshan Begum

School of Medicine Publications

Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. However, there is growing evidence that GBP may be effective and clinically beneficial in both psychiatric disorders and substance use disorders. This review aimed to perform a systematic analysis of peer-reviewed published literature on the efficacy of GBP in the treatment of psychiatric disorders and substance use disorders.

Methods: This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …

Film Review: The Impure: An Abolitionist Documentary Film Of The 19th Century Traffic In Jewish Women, Caroline Norma

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.

Female Genital Mutilation In The United States: Estimating The Number Of Girls At Risk, Phyllis Chesler

Dignity: A Journal of Analysis of Exploitation and Violence

Female genital mutilation (FGM) destroys the capacity of women to experience sexual pleasure. It causes serious medical complications such as bleeding, painful urination, cysts, dangerous and recurrent bladder and urinary tract infections, the growth of scar tissue that make marital intercourse a nightmare and that turns childbirth into an experience of danger and torture. Due to immigration, FGM now poses a potential health crisis in the West, both in Europe and in the United States. To estimate how many girls who live in the West are at risk, one can measure the prevalence of FGM in the non-Western countries where …

Becoming Legible: The Racial Making Of The Negro Mascogo/Black Seminole People In The Coahuila–Texas Borderland, Rocío Gil Martínez De Escobar

Dissertations, Theses, and Capstone Projects

This historical ethnography analyzes the making of the Negro Mascogo/Black Seminole people as part of the production of the Coahuila-Texas borderland. In the quest to become legible to improve their living conditions and maintain a sense of dignity, Negros Mascogos/Black Seminoles use history and racialization as tools of negotiation between themselves and the two nation-states where they live: Mexico and the United States. I analyze the Negro Mascogo/Black Seminole people as a case of racialization that illustrates the ongoing mechanisms of settler colonialism (dispossession, exploitation, and elimination via genocide or assimilation), as they play out in specific socio-historical contexts.

The …

Essays On Paid Family Leave In The United States, Beila R. Leboeuf

Dissertations, Theses, and Capstone Projects

Chapter 1: The first chapter is a literature survey that reviews the empirical research conducted on paid family leave in the United States. This chapter summarizes the documented benefits of paid family leave on women's labor force participation, leave usage, and children's health. Also, evidence that suggests potentially harmful effects of paid family leave is discussed. Possible directions for future research are explored, and the chapter concludes by considering the implementation of a national paid family leave program in the United States.

Chapter 2: The second chapter replicates and extends the results of Rossin-Slater et al. (2013). The purpose of …

A Credible Fear: The Politics Of Gang Violence In The Northern Triangle, Jane E. Dowd

Dissertations, Theses, and Capstone Projects

This thesis will create an argument for how the victims of gang violence from the Northern Triangle nations of El Salvador, Guatemala, and Honduras qualify for asylum in the United States based on a well-founded fear of persecution. An analysis of the legal framework of the asylum system in the United States, profiles of the two largest gangs in the Northern Triangle the Mara Salvatrucha and Barrio 18, a profile of the asylum seekers arriving at the United States border, the criminal activity that the gangs engage in, and the way that this activity is political in nature will form …

Efficient Private Information Retrieval, Konstantinos Nikolopoulos

Dissertations, Theses, and Capstone Projects

A vast amount of today's Internet users' on line activities consists of queries to various types of databases. From traditional search engines to modern cloud based services, a person's everyday queries over a period of time on various data sources, will leave a trail visible to the query processor, which can reveal significant and possibly sensitive information about her. Private Information Retrieval (PIR) algorithms can be leveraged for providing perfect privacy to users' queries, though at a restrictive computational cost. In this work, we consider today's highly distributed computing environments, as well as certain secure-hardware devices, for optimizing existing PIR …

New Perspectives About Financial Intermediation: Disruption By Senior Managers And Financial Technologies, Yu Shan

Dissertations, Theses, and Capstone Projects

This dissertation consists of three chapters that span managerial styles, financial technologies, and social interactions.

Chapter 1 Banks increase credit risk-taking in syndicated bank loans when their systemic risk increases; however, the interrelationship across risks depends on bank managerial styles. Using a connectedness sampling method to differentiate patterns of business policy styles and systemic risk-taking among managers, I find that credit risk-taking is more sensitive to the bank's systemic risk if the manager exhibits a preference for systemic risk. Asset-innovating managers (exhibiting a preference for non-traditional forms of income and assets) take higher credit risk in their loan portfolios, but …

Everyday Violence: Catcalling And Lgbtq-Directed Aggression In The Public Sphere, Simone A. Kolysh

Dissertations, Theses, and Capstone Projects

My dissertation aims to expose how women and Lesbian, Gay, Bisexual, Transgender and Queer (LGBTQ) people are barred from full participation in the public sphere and public life because of catcalling and LGBTQ-directed aggression on the streets of New York City. The harmful, cumulative, and long-lasting effects of these interactions make it difficult for marginalized people to belong and benefit from a supposedly inclusive and democratic society. Focusing on the public sphere of New York City, this dissertation is a qualitative study of catcalling and LGBTQ-directed aggression. I analyze interviews with catcallers and sixty-seven recipients of everyday violence as well …

'We Are Abolitionizing The West': The Union Army And The Implementation Of Federal Emancipation Policy, 1861–1865, Scott Ackerman

Dissertations, Theses, and Capstone Projects

This project provides a new history of the implementation of federal emancipation policy by the Union armies during the Civil War. It examines five geographic regions occupied by the Union army—the Mississippi River Valley, Tennessee, Alabama, Louisiana and the Gulf Coast, and Kentucky—focusing on the activities of officials whom I term the “middle managers” of federal emancipation policy. Though often overlooked by historians, officers such as Union army Adjutant General Lorenzo Thomas, Commissioner for the United States Colored Troops George Stearns, and Major William Sidell were specifically designated by the Lincoln administration to superintend the implementation of emancipation policy in …

Clothing The Black Body In Slavery: What They Wore And How It Was Made, Wanett I. Clyde

Dissertations, Theses, and Capstone Projects

After suffering the traumas of capture, enslavement and the ship's journey from their homeland, newly arrived Black people, along with struggling to understand and cope with their reduced circumstances, were often pulled in multiple directions with regard to their appearance. Stripped of garments that represented their native culture and forbidden to practice their personal grooming habits, slaves were now reliant on their owners for care. Once a slave was purchased, it was in the best interest of the master and mistress to protect their investment by providing them with the essentials. Chief among those necessities were clothing.

This thesis will …

The Counseling Advantages Of Rechargeable Hearing Aid Batteries, Belinda M. Sun

Dissertations, Theses, and Capstone Projects

Rec­­hargeable battery hearing aids offer the user many benefits over disposable battery hearing aids. They are easier and more convenient to handle, are environmentally friendly, and offer peace of mind as the charge is not expected to run out during the day. Another potential benefit of rechargeable battery hearing aids is that because rechargeable battery hearing aids are simpler to manage than disposable hearing aid batteries, the time taken to counsel and teach patients about battery handling and maintenance with rechargeable batteries is expected to be less than the time needed for orientation with disposable batteries. The purpose of this …

Presenciar El Pasado: Witnessing The Spanish And Argentine Dictatorships Through Film And Television, Kristina L. Jacobs

Dissertations, Theses, and Capstone Projects

This dissertation explores the ways in which recent (1999–2017) films and television series ask today’s spectators to witness the 20^th-century Spanish and Argentine dictatorships by analyzing these texts on both a narrative and technical level. I examine torture in the Argentine films Garage Olimpo (Marco Bechis, 1999), Crónica de una fuga (Andrés Caetano, 2006), and, from Spain, La voz dormida (Benito Zambrano, 2011). I also investigate the theme of disappearance as seen in two Spain-Argentina joint ventures, Pasaje de vida (Diego Corsini, 2015) and Los pasos perdidos (Manane Rodríguez, 2001), both of which portray how parental absence affects …

Migritude: Migrant Structures Of Feeling In A Minor Literature Of Globalization, Ashna Ali

Dissertations, Theses, and Capstone Projects

Migritude: Structures of Feeling in a Minor Literature of Globalization examines contemporary postcolonial narratives of migration written by women of color writing in English and in Italian under the rubric of “migritude.” Migritude literature describes the work of a disparate yet distinct group of contemporary authors whose work describes the condition of being a migrant under globalization with a critical feminist and anti-imperialist politics and poetics. It is a global justice movement that sees literature as a form of cultural activism. Migritude literatures traces the connections between contemporary globalization and colonial processes of the past and sheds light on how …

“How To Lose The Hounds”: Tracing The Relevance Of Marronage For Contemporary Anti-Police Struggles, Celeste Winston

Dissertations, Theses, and Capstone Projects

This dissertation analyzes the interconnected practices of flight from slavery and flight from policing. Focusing on Black communities within Montgomery County, Maryland, I provide evidence for how local legacies of enslavement and flight from slavery have empowered later generations of residents, including people still living there today, to practice safety and security on their own terms, beyond policing. I draw on archival and ethnographic research in seven Black communities in Montgomery County to document historical and ongoing local Black life practices and organizing against and outside of policing. I center these communities’ past and present placemaking and collective strategies of …

An Investigation Of Alkylboron Transmetallation In Palladium-Catalyzed Suzuki Reactions, Benjamin Murray

Dissertations, Theses, and Capstone Projects

Through the past 40 years, carbon-carbon cross-coupling reactions have greatly enhanced the ability of chemists to synthesize C(sp²)-C(sp²) bonds and more recently C(sp²)-C(sp³) bonds. In particular, the Suzuki reaction has proven to be invaluable with its high yields, good functional group tolerance, and low toxicity of reagents. One of the component steps of the catalytic cycle of this reaction is transmetallation, in which the nucleophilic species transfers its organic component to the metal center (generally palladium). The mechanism of transfer from primary alkylboron nucleophiles was studied in the 1990's via use of …

A Pretargeted Spect Imaging Strategy Employing Technetium-99m Based On Bioorthogonal Diels-Alder Click Chemistry, Justin H. Walsh

Dissertations, Theses, and Capstone Projects

A series of related N₃S ^99mTc-peptide complexes were synthesized and tested for use in pretargeting SPECT imaging that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the ^99mTc-peptide complexes for maximum tumor targeting with the in vivo “click” and minimum non-target uptake. The ^99mTc–tetrazine constructs were prepared by reaction of ^99mTc-peptide complexes (^99mTc-FKC, ^99mTc-FKCR, ^99mTc-DKC, and ^99mTc-SKC) with Tz-NHS or Tz-PEG₅-NHS to form ^99mTc FK(Tz)C, ^99mTc-FK(PEG₅-Tz)CR, ^99mTc-DK(PEG₅-Tz)C, …

Mechanical Kingdoms: Sound Technologies And The Avant-Garde, 1928–1933, Lauren Rosati

Dissertations, Theses, and Capstone Projects

Against accepted histories of the historical avant-garde, which have elevated artistic production in traditional media while suppressing sonic practices, this dissertation argues that artist-engineers working across Europe and the United States independently, if simultaneously, turned their attention to emerging sound technologies as new media for creative experimentation by the early 1930s. This spectrum of activity demonstrates the significance of sound in avant-garde practice, and indicates a wide-ranging artistic engagement with technological devices intended for mass audiences. While the common understanding of the relation between art and technology in this period amounts to one of mere enthusiasm for the novel formal …

Between Politics And Morality: Hans Kelsen's Contributions To The Changing Notion Of International Criminal Responsibility, Jason Kropsky

Dissertations, Theses, and Capstone Projects

The pure theory of law analyzes the legal normative basis of jurisprudence. According to its author, Hans Kelsen (1881-1973), the study of law as a science can only arise once “alien elements” associated with sociology, politics, ethics and psychology are extracted from strict legal cognition. But what happens when the international sphere of law that possesses the special quality of holding state officials accountable for core international crimes requires intrusion by extra-legal sources? Does Kelsen’s structural edifice collapse? Or is it reconstituted? In examining how international criminal responsibility, a test case for Kelsen’s positive law claims derives its legitimacy, this …

The Subject Of Jouissance: The Late Lacan And Gender And Queer Theories, Frederic C. Baitinger

Dissertations, Theses, and Capstone Projects

The Subject of Jouissance argues that Lacan’s approach to psychoanalysis, far from being heteronormative, offers a notion of identity that deconstructs gender as a social norm, and opens onto a non-normative theory of the subject (of jouissance) that still remains to be fully explored by feminist, gender, and queer scholars. Drawing mostly on the later Lacan, The Subject of Jouissance shows that by locating the identity of the subject in the singularity of its bodily mode of enjoyment (that Lacan calls “jouissance”), and not in the Imaginary illusions of the ego, nor in the Symbolic social structures, Lacan fosters thinking …

Getting At The Surface: A Promoter And Coding Sequence Characterization Of An Odorant Receptor, Irena G. Parvanova

Dissertations, Theses, and Capstone Projects

Odorant receptors (ORs) are expressed by mature olfactory sensory neurons (OSNs), in a monogenic and monoallelic fashion (singular gene choice). It has been repeatedly published that the singular expression of ORs is a consequence of epigenetic regulation. The model invokes the depositing of epigenetic marks (off marks) that reflect transcriptional inactivity on all OR genes in immature neurons followed by the activation of one OR allele in maturing neurons. OR expression has been exclusively studied via transgenic animal models, due to the lack of cell line system that can undergo singular gene choice. Here, we used chromatin immunoprecipitation-quantitative polymerase chain …

Childhood Neglect And Risk Of Revictimization By An Intimate Partner: A Prospective Investigation Of Mediational Pathways, Rebecca M. Spizzirri

Dissertations, Theses, and Capstone Projects

Childhood maltreatment increases risk of revictimization in adulthood, although knowledge is limited. Very few studies focus on children with histories of neglect or include males. In addition, while some studies have begun to examine potential pathways from childhood victimization to adult revictimization, there is heavy reliance on data from cross-sectional or short-term longitudinal studies. This dissertation examines data from a large prospective cohort design study to examine potential mediators between childhood neglect and revictimization by an intimate partner in adulthood. Children with official records of neglect experienced before age 12 and non-maltreated children matched on the basis of age, sex, …

American Democratic Deficit In Assisted Reproductive Technology Innovation, Myrisha S. Lewis

Faculty Publications

In many areas of innovation, the United States is a leader, but this characterization does not apply to the United States' position in assisted reproductive technology innovation and clinical use. This article uses a political science concept, the idea of the "democratic deficit" to examine the lack of American public discourse on innovations in ART. In doing so, the article focuses on America's missing public consultation in health care innovation. This missing discourse is significant, as political and ethical considerations may impact regulatory decisions. Thus, to the extent that these considerations are influencing the decisions of federal agency employees, namely …