Digital Commons Network^™

Risk Of Late-Onset Depression In Long-Term Survivors Of Breast, Prostate, And Colorectal Cancer, Melissa Taylor, Sarah Westvold, Jessica Long, Terry Hyslop, Andrea Silber, Rebecca Forman, Faiza Yasin, Tendai Kwaramba, Shi-Yi Wang, Michael Leapman, Michael Cecchini, Ira Leeds, Lisa Spees, Stephanie Wheeler, Cary Gross, Kevin Oeffinger, Michaela Dinan

Kimmel Cancer Center Faculty Papers

IMPORTANCE: The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression.

OBJECTIVE: To identify risk factors associated with late-onset depression in long-term (5-year) survivors of breast, prostate, or colorectal cancer.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used 2022 linkage of Surveillance, Epidemiology, and End Results (SEER) and Medicare data to identify 5-year survivors of breast, prostate, or colorectal cancer 66 years or older who were enrolled in fee-for-service Medicare and had no previous depression diagnosis. Long-term …

November 3, 2025

The Gavel Gazette

No abstract provided.

Social Media Sponsorship: Metrics And Strategies For Finding The Right Content Creator-Sponsor Matches, Shahryar Doosti, Stephanie Lee, Young Tan

Business Faculty Articles and Research

Social media video sponsorship, where sponsors partner with content creators to promote their brands, has become increasingly popular. Leveraging rich data on sponsored and nonsponsored videos on Facebook, we introduce two metrics, Content Similarity and Audience Closeness, to help sponsors find effective creator-sponsor matches. Content Similarity captures the thematic alignment between a creator’s content and a sponsor’s brand, whereas Audience Closeness measures how closely aligned a creator’s and sponsor’s audiences are within a social media network. We find that both metrics significantly increase video viewership, but their effects vary over time. Audience Closeness generates more immediate, short-term engagement, whereas …

Enhancing Evidence-Based Practice In Embase (Evidence-Based Practice Council Monthly Meeting), Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

No abstract provided.

Ai Mediation — Ethically Questionable?, Steven Nappi

Cardozo Journal of Conflict Resolution (CJCR) Blog

Artificial Intelligence (“AI”) is an imperative aspect of modern society. However, in the legal field, AI must be used with the utmost discretion. Earlier this year, an attorney from Utah used ChatGPT to create a brief which produced a case that does not exist. In response, the Utah Court of Appeals sanctioned the attorney. Nevertheless, at the 2025 ABA TECHSHOW, a legal tech startup launched an artificial intelligence mediator.

Evidently, an attorney cannot ethically use AI to write a brief defending their client in litigation. Yet, the underlying question remains: why should AI be replacing human mediators?

The print edition …

Día De Los Muertos | Memorial Event &Altar, School Of Architecture And Planning, Latin American & Iberian Institute

LAII Events

Monday, November 03, 2025 | 12:00 pm

George Pearl Hall

About:

Join the School of Architecture and Planning and the LAII for a Día de los Muertos memorial event where 'Pan de Muerto' and 'Champurrado' will be served.

Come add photographs of your loved ones to the Día de los Muertos altar! Photographs will remain on the altar until Friday, November 7.

Notes:

This event is free and open to the public.

Developing Middle School Students’ Systems Thinking In Earth Science Through Dynamic Simulations: The Case Of The Rock Cycle, Nicole Panorkou, Amanda Provost, Gabriella Migliore

Department of Mathematics Faculty Scholarship and Creative Works

In this paper, we discuss the development of students’ systems thinking about the rock cycle as they interact with an instructional module that includes three interactive simulations and accompanying questioning. We present the reasoning of six students from a whole-class design experiment in a sixth-grade classroom to describe how students’ systems thinking may be constructed and reorganized through activity with our design. Our findings highlight a framework of students’ systems thinking about the rock cycle that builds and expands prior work to specific sub-components. We also discuss an emerging framework for supporting students’ systems thinking through careful design of simulation …

Hiding In Plain Sight, Evan Seeling

Theses

This thesis considers how perceptual, emotional, and behavioral patterns—often inherited, unnoticed, or obscured—can be revealed through the optical phenomena of glass. It connects visual experience with themes of grief, memory, and identity, using glass to explore the boundary between what is seen and what is felt. Through material investigations in refraction, reflection, and spatial arrangement, the studio research examines how glass can both obscure and reveal, echoing the instability of perception itself. These investigations, paired with a focus on viewer interaction, suggest that patterns hiding in plain sight become visible through intentional acts of perception and reflection.

Effects Of Yttrium And Barium Trace Impurities On The Dielectric Properties Of  Srtio3 (111) Single Crystals At Cryogenic Temperatures, Hung Trinh, Alan Devoe, Fatih Dogan

Materials Science and Engineering Faculty Research & Creative Works

Commercially available single crystals of (111) SrTiO₃ were found to contain impurities of varying amounts that strongly affected their dielectric performance at cryogenic temperatures. Three crystals with total impurities of 111, 126, and 625 ppm, primarily of barium and yttrium, were analyzed. Relative permittivity (εr) and loss tangent were investigated with high resolution as a function of temperature (4 K to 100 K), DC voltage (0 V/cm to 800 V/cm), and frequency (100 Hz to 1 MHz). An impurity level as low as ≈500 ppm barium resulted in an increase of the maximum permittivity (εm) to approximately 50,000 at …

Validation Of A Risk Score For Cancer-Associated Thrombosis Using Nationwide Ehr Data, Ang Li, Omid Jafari, Barbara D Lam, Jun Y Jiang, Rock Bum Kim, Shengling Ma, Emily Zhou, Joyce W Tiong, Elizabeth C Chiang, Justine Ryu, Christopher I Amos, Jennifer La, Nathanael R Fillmore

Faculty, Staff and Student Publications

Importance: Venous thromboembolism (VTE) is associated with increased mortality and morbidity in patients with cancer. Existing risk prediction models are typically validated within individual sites, a fragmented approach that limits clinical adoption.

Objective: To validate the electronic health record cancer-associated thrombosis (EHR-CAT) score compared with the benchmark Khorana score in a contemporary cohort of patients with cancer across the nation, before and after treatment, excluding those at high risk of bleeding.

Design, setting, and participants: This prognostic study included patients in a nationwide longitudinal EHR database from January 2018 to December 2023 with follow-up continuing to April 2025. Patients with …

East 93rd St Associates Lp V. Walters

All Decisions

In this nonpayment proceeding, the tenant moved for summary judgment seeking to bar the landlord from collecting rent under MDL § 302-a due to a rent-impairing violation and asserting a harassment counterclaim. The court denied summary judgment on the MDL § 302-a claim, ruling that the tenant failed to conclusively prove that HPD mailed the notice of violation to the landlord, a material element of the defense. The harassment claim, based on the landlord's repeated failure to make repairs, was also denied as an issue of fact existed regarding the tenant's alleged refusal to provide access. The case was adjourned …

Ksu Faculty Brass Quintet

Bailey School of Music Concert Programs

KSU Faculty Brass Quintet

Alcohol And Metabolic Stress Synergize To Dysregulate Mitochondrial Health And Lipid Metabolism; Evidence From A Hepatocyte Spheroid Model, Eden M. Gallegos, Kaitlin Couvillion, Drake Darden, Keishla Rodriguez-Graciani, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

Metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease frequently co-occur, manifesting as MetALD. Understanding the hepatocyte-specific effects of alcohol and metabolic stressors is critical to uncovering mechanisms of synergistic injury. This study evaluated the individual and combined effects of ethanol, sugars, and saturated/monounsaturated fats on hepatocyte lipid metabolism, oxidative stress, and mitochondrial function using a 3D human HepaRG spheroid model. HepaRG spheroids were treated with ethanol (50 mm), sugar (glucose and fructose), and fatty acids alone or in combination for 10 d. The combination of ethanol (E) and metabolic (sugar and fat, SF) stressors (ESF) synergistically increased triglyceride content …

Human Kallikrein 2: A Novel Lineage-Specific Surface Target In Prostate Cancer, Fei Shen, Ryan Smith, Theresa Mcdevitt, Krista Menard, Shaozhou Tian, Gerald Chu, Ruchi Chaudhary, Jennifer Mccann, Halley Oyer, Sherry C. Wang, Steven Max, Peter Francis, William K. Kelly, Charles G. Drake

Kimmel Cancer Center Faculty Papers

PURPOSE: Targeted therapies for metastatic prostate cancer are limited, highlighting the need for novel drug targets and mechanisms of action (MoA). Human kallikrein 2 (KLK2) is a prostate-specific antigen expressed across the prostate cancer disease continuum. However, it was not recognized as a therapeutic target for prostate cancer in the past due to limited evidence of its cell surface expression. In this study, we systematically characterized KLK2 expression in prostate cancer, confirmed its cell surface expression, and demonstrated the preclinical efficacy of three KLK2-targeting therapeutics with distinct MoA.

EXPERIMENTAL DESIGN: The KLK2 expression profile in different stages of prostate cancer …

Genomic Profiling Of Intraocular Leiomyomas Reveals Recurrent Copy Number Alterations, Vivian Tang, Yubai Chou, Cuyan Demirkesen, Michele M. Bloomer, Joseph B. Crawford, Ahmet M. Sarici, Carol L. Shields, Ralph C. Eagle Jr., Codrin E. Iacob, Walter P. Devine, Tatyana Milman, Melike Pekmezci

Wills Eye Hospital Papers

PURPOSE: Leiomyomas are benign smooth muscle tumors that commonly present in the uterus, soft tissue, skin, and gastrointestinal tract but in rare cases can also arise within the eye. Notably, intraocular leiomyomas often show slightly different histopathologic and immunohistochemical features, referred to as mesectodermal morphology, given their presumed neural crest origin. Genetic and cytogenetic alterations of intraocular leiomyomas, as well as their association with various clinical and histopathologic features, have not been previously studied.

METHODS: We identified eight patients diagnosed with intraocular leiomyoma and performed targeted next-generation sequencing, whole transcriptome RNA sequencing, and chromosomal copy number analysis on those with …

National Alliance Of Sickle Cell Centers Consensus Recommendations On Sickle Cell Disease Health Maintenance: A Consensus Statement, Seethal A. Jacob, Melissa Frei-Jones, Sana Saif-Ur-Rehman, Monica L. Hulbert, Andrew R. W. O'Brien, Crawford Strunk, Anthony Villella, Ravi Talati, Amma Owusu-Ansah, Francis Coyne, Patrick T. Mcgann, Parul Rai, Robin Miller, Angeli Rampersad, Vishwas Sakhalkar, Neha Bhasin, Deepa Manwani, Sophie Lanzkron, Julie Kanter

Cardeza Foundation for Hematologic Research

IMPORTANCE: The most common inherited blood disorder in the world, sickle cell disease (SCD) is a known global health concern. While survival of children into adulthood has improved significantly over the last few decades in high-resource countries, substantial gaps in care standards and limited practice harmonization persist.

OBJECTIVE: To provide up-to-date recommendations for preventive care and treatment of all people living with SCD and its related comorbidities.

EVIDENCE REVIEW: As part of the National Alliance of Sickle Cell Centers (NASCC), 41 pediatric and adult sickle cell disease experts developed consensus standards and recommendations based on available evidence and expert consensus …

Developing Optogenetic Approaches To Study Ca2+ Signaling Processes, Tatsuki Nonomura, Xiaoxuan Liu, Megan Chiu, Zhi Tan, Tien-Hung Lan, Yubin Zhou

Faculty, Staff and Students Publications

Calcium ions (Ca2+) are essential second messengers intimately implicated in a variety of biological processes, ranging from short-term events such as muscle contraction to long-term effects like gene expression. Dysregulated Ca2+ signaling can disrupt cellular function and contribute to the development of various human diseases, including developmental, neurological, immunoinflammatory, metabolic, and cardiovascular disorders. To study the mechanisms and biological consequences of Ca2+ signaling, optogenetic approaches have proven invaluable, as they offer exceptional spatiotemporal resolution compared to traditional methods. Recent progress in non-opsin-based optogenetics, particularly those engineered from Ca2+ release–activated Ca2+ (CRAC) channels, has substantially advanced our understanding of Ca2+ signaling …

Orphan Nuclear Receptor 4a1 (Nr4a1) And Nr4a2 Are Endogenous Regulators Of Cd71 And Their Ligands Induce Ferroptosis In Breast Cancer, Arafat Rahman Oany, Srijana Upadhyay, Wai Ning Tiffany Tsui, Amanuel Hailemariam, Sarah Latka, John D Landua, Sandra D Scherer, Alana L Welm, Hugo Villanueva, Michael T Lewis, Stephen Safe

Faculty, Staff and Students Publications

Ferroptosis is an iron-dependent cell death pathway that involves multiple genes, including the transferrin receptor (TFRC/CD71), glutathione peroxidase 4 (GPX4) and cystine-glutamate antiporter (SLC7A11). This study is based on the hypothesis that orphan nuclear receptor 4A1 (NR4A1) and NR4A2 maintain low levels of ferroptosis in triple negative breast cancer (TNBC) cells and bis-indole derived (CDIM) compounds act as NR4A1/2 ligands that induce ferroptosis by enhancing CD71 expression. 1,1-Bis(3'-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) analogs were investigated for their cytotoxicity and effects on NR4A1 and NR4A2 regulated genes and induction of ferroptosis. Several assays also determined enhanced lipoperoxidation, reactive oxygen species and malondialdehyde formation in …

Burden Of Central Nervous System Cancer In The United States, 1990-2021, Hyun Jin Han, Yun Seo Kim, Seoyeon Park, Jae Il Shin, Min Seo Kim, Ju Hyung Moon, Yong Bae Kim, Hazim S Ababneh, Ahmed Abu-Zaid, Demelash Areda, Santhosh Arul, Ahmed Y Azzam, Mainak Bardhan, Mohammad Amin Bayat Tork, Babak Behnam, Gokce Belge Bilgin, Prarthna V Bhardwaj, Soumitra S Bhuyan, Nima Broomand Lomer, Meng Xuan Chen, Suma Sri Chennapragada, Xiaochen Dai, Frances E Dean, Sindhura Deekonda, Xueting Ding, Ojas Prakashbhai Doshi, Abdel Rahman E'Mar, Muhammed Elhadi, Jawad Fares, Patrick Fazeli, James L Fisher, Maryam Fotouhi, Ali Gholamrezanezhad, Fidelia Ida, Chidozie Declan Iwu, Mohamed Jalloh, Chinmay T Jani, Rizwan Kalani, Samuel Berchi Kankam, Foad Kazemi, Ariz Keshwani, Atulya Aman Khosla, Stephen S Lim, Riffat Mehboob, Tomislav Mestrovic, Ali H Mokdad, Christopher J L Murray, Gurudatta Naik, Zuhair S Natto, Dang Nguyen, Fred Nugen, Atakan Orscelik, Romil R Parikh, Louise Penberthy, Richard G Pestell, Disha Prabhu, Jagadeesh Puvvula, Shakthi Kumaran Ramasamy, Cameron John Sabet, Austin E Schumacher, Yigit Can Senol, Sunder Sham, Samendra P Sherchan, Gizeaddis Lamesgin Simegn, Jasvinder A Singh, Ranjan Solanki, Bahadar S Srichawla, Jabeen Taiba, Manoj Tanwar, Mike Tuffour Amirikah, Anjul Verma, Ismaeel Yunusa, David X Zheng, Dong Keon Yon, Keun Young Park

Faculty, Staff and Students Publications

Importance: Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States.

Objective: To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and Sociodemographic Index (SDI).

Design, setting, and participants: This cross-sectional study involved a repeated analysis of Global Burden of Disease Study (GBD) 2021 data in 2024. Using data from 183 sources, CNS cancer metrics in the US were estimated across states and years. US CNS cancer metrics across all sexes …

A Multiomics Recovery Factor Predicts Long Covid In The Impacc Study, Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Caitlin Syphurs, Tianyi Chu, Naresh Doni Jayavelu, David B Corry, Farrah Kheradmand, Lindsey R Baden, Rafick-Pierre Sekaly, Grace A Mccomsey, Elias K Haddad, Charles B Cairns, Nadine Rouphael, Ana Fernandez-Sesma, Viviana Simon, Jordan P Metcalf, Nelson I Agudelo Higuita, Catherine L Hough, William B Messer, Mark M Davis, Kari C Nadeau, Bali Pulendran, Monica Kraft, Chris Bime, Elaine F Reed, Joanna Schaenman, David J Erle, Carolyn S Calfee, Mark A Atkinson, Scott C Brakenridge, Esther Melamed, Albert C Shaw, David A Hafler, Alison D Augustine, Patrice M Becker, Al Ozonoff, Steven E Bosinger, Walter Eckalbar, Holden T Maecker, Seunghee Kim-Schulze, Hanno Steen, Florian Krammer, Kerstin Westendorf, Bjoern Peters, Slim Fourati, Matthew C Altman, Ofer Levy, Kinga K Smolen, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Leying Guan, Lauren Ir Ehrlich

Faculty, Staff and Students Publications

Background: Following SARS-CoV-2 infection, approximately 10%–35% of patients with COVID-19 experience long COVID (LC), in which debilitating symptoms persist for at least 3 months. Elucidating the biologic underpinnings of LC could identify therapeutic opportunities.

Methods: We utilized machine learning methods on biologic analytes provided over 12 months after hospital discharge from more than 500 patients with COVID-19 in the IMPACC cohort to identify a multiomics “recovery factor,” trained on patient-reported physical function survey scores. Immune profiling data included PBMC transcriptomics, serum O-link and plasma proteomics, plasma metabolomics, and blood mass cytometry by time of flight (CyTOF) protein levels. Recovery factor …

Abdominal Ultrasound Image Dataset For Organ Classification And Disease Detection, Sifat Zina Karim

Research Data

This is a dataset of Ultrasound (US) images of abdominal organs. US imaging is widely accessible and a very common diagnostic tool, as it is non-invasive and does not involve radiation risk. This dataset was curated solely for research in deep learning, with potential applications in supervised, semi-supervised, and unsupervised learning to support disease detection in resource-constrained settings.

The dataset comprises 5,468 unique images of different abdominal organs, namely: Abdominal Aorta (0), Gallbladder (1), Hepatic Vein (2), Kidneys (3), Liver (4), Ovaries (5), Pancreas (6), Portal Vein (7), Spleen (8), and the Urinary System (9), which includes the Urinary Bladder, …

Expanding Ode Examples: Introducing Gene Regulation Dynamics Through Hill Functions, Maila Hallare, Jane M. Santamore

CODEE Journal

Gene regulation is a fundamental biological process that controls gene expression. It can explain phenomena such as cell differentiation, circadian rhythms, disease progression, and metabolic control, among many others. Despite their importance in mathematical biology, gene regulation models are rarely featured in traditional ODE textbooks, which focus mainly on examples from engineering, physics, chemistry, and population biology. This article introduces gene regulation dynamics as a valuable addition to ODE curricula, presenting the models from a mathematical perspective and building on properties of the Hill function. These models deepen the understanding of biology-inspired ODE applications, provide accessible research opportunities for students, …

Ndls Communicator: Week Of 11.03.25, Notre Dame Law School

NDLS Communicator

The Latest News

• ND Law Professor Jimmy Gurulé discusses Exoneration Justice Clinic's work in an interview with renowned journalist Carmen Aristegui
• The Global Human Rights Clinic participated in a series of high-level engagements during International Law Week at the United Nations Headquarters in New York.

Faculty Briefs

• Mary Ellen O'Connell
• Daniel Slate
• Emily Bremer
• Christine Venter
• Nicole Garnett and Maria Paz Madrid
• Derek Muller

Events

• Faculty Colloquium
• Veterans Law Presentation
• Politics and the DOJ
• The Meaning of Natural
• Justice Amy Coney Barrett Moot Court Tournament Semi-Finals
• Provost Open Office Hours
• Rice-Hasson Distinguished Lecture Series

Around the Watercooler

• Staff Spot Awards

Systematic Review Of Elementary Cybersecurity Education: Curriculum, Pedagogy, And Barriers, Na Liu, Siyu Long, Florence Martin

Journal of Cybersecurity Education, Research and Practice

Abstract -As children increasingly engage with digital platforms, the need for effective cybersecurity education has become urgent. This systematic review synthesizes 81 studies published between 2017 and 2024 to examine global curricula research focus and topics, pedagogical approaches and assessment methods, and key challenges in elementary cybersecurity education. The findings reveal six major thematic categories: student awareness, parental mediation, teacher engagement, curriculum design, community and policy support, and pedagogical innovation. Among instructional strategies, game-based learning and narrative storytelling emerge as the most frequently explored. Despite this growth, major gaps remain in curriculum consistency, teacher preparation, assessment rigor, and stakeholder coordination. …

The Experience Of Administrative Burdens In Snap And Medicaid: New Evidence From A Nationally Representative Survey Of Low-Wage Workers, Stephen Roll, Mathieu Despard, Yung Chun

Center for Social Development Research

When functioning correctly, the U.S. social safety net ensures that everyone can reach a basic standard of living, regardless of economic circumstances, and provides financial support to help families who have fallen on hard times due to job losses or other adverse life events. However, the programs often have complex rules around eligibility, documentation requirements, and compliance. Those features and negative experiences with program staff impose psychological costs—collectively referred to as administrative burdens—that can make enrolling and staying in the programs difficult for many families. Drawing upon data from the Workforce Economic Inclusion and Mobility Survey of a nationally …

Student Life E-Newsletter November 3, 2025, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

A Temperature-Sensitive Crispr-Cas12a System For Sterile Insect Technique, Christina Nguyen, Ahmed Idowu Omotayo, Sara Sanz Juste, Xuechun Feng, Víctor López Del Amo

Faculty, Staff and Student Publications

The sterile insect technique (SIT) reduces population numbers by releasing sterile males that produce non-viable progeny. Specifically, CRISPR/Cas9-based precision-guided SIT (pgSIT) generates sterile males through genetic crosses of two transgenic lines: a Cas9 strain and a guide RNA (gRNA) strain targeting male sterility and female viability or infertility. However, pgSIT requires separate maintenance of the two lines and sorting to obtain sterile males, creating possible challenges for scaling. To overcome this, we propose using Cas12a nuclease, which is inoperative at lower temperatures but active at higher temperatures. Here, we develop a Cas12a-based pgSIT system involving a single strain containing both …

Chinese Women’S Rising Refusal Of The Family : The Problems, The Resistance, The Post-Family And Post-Capitalist Work Imaginaries, Peier Chen

Lingnan Theses (MPhil & PhD)

A new generation of Chinese women is questioning the family by examining internal contradictions in parent-child relationships, particularly in how intimacy and care are enacted, while also challenging the legitimacy of the family institution that underpins gendered divisions of labor and hierarchies. Some of them are revealing the problems within the family and refusing patriarchal marriage and family as their daily act of resistance. Their resistance extends beyond the family, into their workplaces, where gender division and hierarchies are also at work. This emerging phenomenon presses us to theorize today’s family problems, especially concerning those related to women’s gendered oppression, …

Mmu: 11/03/25-11/09/25, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

Saint of the Week

General Announcements

A Glance At Spark: Multiple Perspectives Of An Innovative Mentorship Program, Sungmin Park, Thomas Peterson

National Youth Advocacy & Resilience Journal

Youths from high-risk settings are often labeled based on their behavior, which leads to cycles of negative stigmatization and punitive interventions. Traditional behavioristic approaches used in schools, courts, and therapy have shown limited success in fostering long-term positive change. The SPARK mentoring program offers an innovative approach by following the principles from Martin Buber's “I and Thou” philosophy to view the youths with a humanistic and spiritual model. The SPARK program is a 10-week peer-mentorship program that connects youth on probation with college students who aspire to be educators. The SPARK program aims to ignite the spirit of hope, healing, …