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Just In Time: The Definitive Reconstruction Of Biblical Chronology From Adam To The Apostolic Age, James Allen Moseley Nov 2025

Just In Time: The Definitive Reconstruction Of Biblical Chronology From Adam To The Apostolic Age, James Allen Moseley

Doctoral Dissertations and Projects

By embedding a relational database of chronology within Scripture, the inspired authors handed down a framework so precise that it surpasses archaeology, carbon dating, and every other ancient record as the most reliable means of reconstructing history—shedding light on the why and how of biblical events by specifying their when.

This study defends that thesis, demonstrating that the Bible presents a continuous timeline from Adam to Christ—a mathematically coherent whole often overlooked or misunderstood by modern scholarship. Many modern chronologists assign speculative dates to Abraham, Moses, or David without grounding them in the Genesis genealogies. Few construct a defensible framework …


Exploring Professors’ Lived Experiences Of Interacting With Artificial Intelligence In The Classroom: A Phenomenological Study, Joshua A. Baltzell Nov 2025

Exploring Professors’ Lived Experiences Of Interacting With Artificial Intelligence In The Classroom: A Phenomenological Study, Joshua A. Baltzell

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to explore the lived experiences of higher education professors’ interactions with AI in their teaching practices. This study was guided by Ajzen’s theory of planned behavior, which provided a contextual understanding of the concepts that influence higher education professors’ perceptions of AI in their classrooms. A qualitative hermeneutical phenomenological design was employed, utilizing a combination of criterion and snowball sampling. There were 13 participants recruited from higher education institutions from around the United States. Semi-structured individual interviews, a letter-writing exercise, and a qualitative survey were used to collect data from participants. Thematic …


Promoting Leadership To Enhance Safety In Aircraft Maintenance: A Phenomenological Study Of Aviation Technical Operations, Komi Tete Nov 2025

Promoting Leadership To Enhance Safety In Aircraft Maintenance: A Phenomenological Study Of Aviation Technical Operations, Komi Tete

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore how leadership styles affect the safety practices and overall performance of aircraft maintenance technicians (AMTs) in aviation Technical Operations (TechOps) environments. The study built on previous research indicating that safe and efficient aircraft operations depend on numerous technical and social processes. It focused on the comprehensive lived experiences of AMTs as they related to leadership influence on safety. The transformational leadership theory and safety culture theory guided the study, aligning with the inquiry by explaining how leaders could influence the behavior, motivation, and safety practices of AMTs. Ensuring the safety …


Factors Shaping Policy For Cybersecurity Resilience In Critical Infrastructure (Ci) Organizations: Proposing An Adaptive Cyber Resilience Policy Model (Acrpm), Raymond Pythias Friedman Nov 2025

Factors Shaping Policy For Cybersecurity Resilience In Critical Infrastructure (Ci) Organizations: Proposing An Adaptive Cyber Resilience Policy Model (Acrpm), Raymond Pythias Friedman

Doctoral Dissertations and Projects

This study examines the factors that influence cybersecurity resilience in private critical infrastructure (CI) organizations, with a focus on governance structures, internal controls, employee attitudes, and cybersecurity capabilities. Although the empirical focus is on private-sector entities, the findings bear significant implications for public policy, given the societal reliance on CI sectors such as energy, telecommunications, and water. Employing a convergent mixed-methods design, the study synthesizes quantitative survey data from cybersecurity professionals with qualitative case studies of CI organizations.

The analysis reveals that internal controls and employee attitudes are the most salient predictors of organizational resilience. Governance exerts an indirect influence …


Understanding The Influence Of Declining Nursing Motivation On Hospital Performance: A Qualitative Mixed Method Case Study, Kisena J. Leverette Nov 2025

Understanding The Influence Of Declining Nursing Motivation On Hospital Performance: A Qualitative Mixed Method Case Study, Kisena J. Leverette

Doctoral Dissertations and Projects

This qualitative single-case study examined how a decline in nursing motivation affects nurse retention and organizational performance in a large urban hospital in Cincinnati, Ohio. The data were collected through in-depth interviews with nurse managers and anonymous surveys administered to registered nurses, resulting in a total of 20 participants. There were three emergent themes discovered from the findings from the interview transcripts and survey responses. Supportive leadership, intrinsic and extrinsic factors, safe staffing and workplace management were the primary emergent themes for this research. This research revealed that open communication, fair compensation, and proactive support from leadership are imperative. Additionally, …


Educational Technology Instruction In Teacher Preparation Programs: A Hermeneutical Phenomenological Study, Madison R. Russell Nov 2025

Educational Technology Instruction In Teacher Preparation Programs: A Hermeneutical Phenomenological Study, Madison R. Russell

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the technological experiences of pre-service educators enrolled in teacher preparation programs in the Southern United States. The theory guiding this study was Mishra and Koehler’s Technological Pedagogical Content Knowledge (TPACK), as it informs the three main categories and four subcategories of knowledge required to use technology effectively in educational settings. The central research question asked what the experiences are of pre-service educators with educational technology instruction and integration while enrolled in teacher preparation programs. To address this research question, individual interviews, focus group sessions, and journal prompts were used for data …


The Study Of The Inevitability Of Adopting Effective Project Management Strategies In Cutting Project Costs And Time Overruns, Fatima Okei Nov 2025

The Study Of The Inevitability Of Adopting Effective Project Management Strategies In Cutting Project Costs And Time Overruns, Fatima Okei

Doctoral Dissertations and Projects

The inevitability of adopting effective project management strategies in cutting project costs and time overruns is the focus of this qualitative single-case study, which investigated the persistent challenges of costs and time overruns in government road maintenance projects in Nigeria. Based on constructivist paradigm and employing a flexible, case study design, data were collected through interviews with 15 experienced professionals and surveys from 10 stakeholders involved in road maintenance in Nigeria. Thematic analysis of the data revealed five major themes: leadership actions, stakeholder behavior, organizational culture, project management strategies, and external constraints. Findings underscored the critical role of transformational leadership, …


Black Men’S Experiences Of Intergenerational Trauma And Identity Development: A Phenomenological Study, Richard N. Tabb Nov 2025

Black Men’S Experiences Of Intergenerational Trauma And Identity Development: A Phenomenological Study, Richard N. Tabb

Doctoral Dissertations and Projects

This qualitative phenomenological study explored how Black men exposed to intergenerational trauma describe their experiences of identity development. Grounded in Vivian Rakoff’s Intergenerational Trauma Theory and William Cross’s Nigrescence Theory, the study employed a transcendental phenomenological design to examine how trauma is transmitted across generations and its implications for Black male identity. This research addresses a critical gap in the mental health field, particularly regarding the historical roots of trauma and their impact on contemporary counseling practices. Findings revealed that the enduring legacy of historical trauma rooted in slavery, systemic racism, and ongoing forms of oppression continues to profoundly shape …


The Positive Influence Of Minority Male Educators: A Phenomenological Study On Their Role And Necessity In Education, Mark V. Sanders Nov 2025

The Positive Influence Of Minority Male Educators: A Phenomenological Study On Their Role And Necessity In Education, Mark V. Sanders

Doctoral Dissertations and Projects

This phenomenological study examined the perceptions and experiences of minority male students in their educational journeys, focusing on the influence of teacher familiarity and cultural awareness. Teacher familiarity referred to shared cultural backgrounds, lived experiences, and relational accessibility that fostered meaningful connections between students and educators. Cultural awareness was examined in relation to minority male educators, who comprised less than 3% of the national educator workforce. Guided by Tinto’s Student Retention Theory, the study explored how academic and social integration influenced student retention and success. The central research question was: What were the experiences of minority male college students regarding …


Training Timothy: An Analysis Of Discipleship And Leadership Development In Multicultural Churches, Philip Thomas Nov 2025

Training Timothy: An Analysis Of Discipleship And Leadership Development In Multicultural Churches, Philip Thomas

Doctoral Dissertations and Projects

As America’s social and cultural landscape continues to diversify, churches face the challenge of fostering contextually relevant, biblically grounded communities characterized by unity in Christ. Church leaders play a crucial role in this process by articulating a shared mission that transcends humanistic cultural differences and working towards a unifying biblical culture, based on a common understanding and vocabulary. The purpose of this qualitative phenomenological study was to examine how church leaders were selected, developed, and mobilized in Protestant multicultural churches in America to create a unifying biblical culture through biblical discipleship in a multicultural context. For this study, discipleship was …


Mental Well-Being, Belonging, And Chronic Absenteeism: A Correlational Study, Crystal D. Woodall Nov 2025

Mental Well-Being, Belonging, And Chronic Absenteeism: A Correlational Study, Crystal D. Woodall

Doctoral Dissertations and Projects

Chronic absenteeism (CA) is an overwhelming issue facing schools in the United States. A lack of a student’s sense of belonging or signs of emotional symptoms are often red flags that can forecast future absenteeism problems with students. CA has been found to have a positive correlation with a student’s sense of belonging and emotional symptoms. Some CA interventions are geared toward increasing a student’s sense of belonging at school and or improvements in overall mental well-being. The purpose of this predictive correlational study was to examine the relationship between students’ self-reported levels of peer relationship problems and emotional symptoms, …


Leveraging Digital Technology To Enhance Spiritual Growth And Inclusivity Among New Members In Church Communities, Kimberley Renay Strother Nov 2025

Leveraging Digital Technology To Enhance Spiritual Growth And Inclusivity Among New Members In Church Communities, Kimberley Renay Strother

Doctoral Dissertations and Projects

Despite swift technological advancements, the implementation of digital technologies inside the church poses considerable problems as well as transformative prospects. The project examines the impact of biblical digital technology in ministry on enhancing spiritual growth, engagement, and inclusivity among women, youth, and senior congregants. It also examines how digital platforms can facilitate a holistic and inclusive ministry that incorporates multiple generations and genders, ensuring the complete engagement of all church members. This praxis initiative was conducted at Third Baptist Church (TBC) in Springfield, Massachusetts, utilizing a mixed-methods approach, incorporating pre- and post-surveys, digital literacy training sessions, observational notes, and website …


Target Consumers For Bottled Tart Cherry Juice, Kynda R. Curtis, Makaylie Langford, Karin E. Allen, Ruby Ward Nov 2025

Target Consumers For Bottled Tart Cherry Juice, Kynda R. Curtis, Makaylie Langford, Karin E. Allen, Ruby Ward

All Current Publications

A study was conducted by Utah State University (USU) in the fall of 2024 to determine western U.S. consumer preferences and willingness to pay for regionally sourced processed food products. Researchers examined consumer preferences, purchasing habits, and pricing for three processed food products, one of which was bottled tart cherry juice (32-ounce bottle). This fact sheet describes the target market (consumer group) for bottled tart cherry juice. Target consumers were identified as those who consume tart cherry juice at least several times weekly.


Comparing Machine Learning, Deep Learning, And Reinforcement Learning Performance In Culex Pipiens Predictive Modeling, Wei Yin, Sanad H. Ragab, Michael G. Tyshenko, Teresa Patricia Feria-Arroyo, Tamer Oraby Nov 2025

Comparing Machine Learning, Deep Learning, And Reinforcement Learning Performance In Culex Pipiens Predictive Modeling, Wei Yin, Sanad H. Ragab, Michael G. Tyshenko, Teresa Patricia Feria-Arroyo, Tamer Oraby

School of Mathematical & Statistical Sciences Faculty Publications

Several machine learning (ML) and deep learning (DL) methods have been used to predict the presence of species in classification problems. Another set of methods, called reinforcement learning (RL), has been used in training agents to perform various tasks, but not in predicting species distribution. Culex pipiens (Diptera: Culicidae), commonly known as the common house mosquito, is a globally distributed species prevalent in temperate and subtropical regions. They serve as a primary vector for West Nile Virus (WNV), a mosquito-borne pathogen that affects humans and other animals. The study objective is to compare the performance of logistic regression, random forest …


Why Christians Should Read And Write Science Fiction An Examination Of The Benefits Of Using Science Fiction To Spread The Gospel, Matthew Ryan Tompkins Nov 2025

Why Christians Should Read And Write Science Fiction An Examination Of The Benefits Of Using Science Fiction To Spread The Gospel, Matthew Ryan Tompkins

Masters Theses

Science fiction is a form of literature that faces many objections from the church that many people may not be aware. Many Christians assume that science fiction is about worlds and technologies that challenge the nature of God’s creation. This assumption is largely because these opposing Christians have neither read or written science fiction. What this Christian opposition doesn’t realize is that whether it be movies, books or television, science fiction continues to grow in popularity as a genre in mainstream media. This growth has created a unique evangelical opportunity to use science fiction to preach to unbelievers. If Christians …


Cold Forged: A Theological Reckoning In Narrative Silence, Craig Steven Wright Nov 2025

Cold Forged: A Theological Reckoning In Narrative Silence, Craig Steven Wright

Masters Theses

This thesis examines the construction of testimonial fiction as an act of moral resistance and theological witness, developed through a creative manuscript (Cold Forged) that embodies a cruciform narrative structure modelled on Isaiah 53 and the Book of Job. The project interrogates institutional betrayal, memory as liturgy, and the intersection of silence and suffering, situating itself within a literary genealogy that includes Flannery O’Connor, Fyodor Dostoevsky, Cormac McCarthy, and C.S. Lewis. The critical paper will explore the aesthetics of theological realism in trauma narrative, and the artist statement will defend the cruciform architecture of narrative silence as an ethical form.


With Love From The Front: Exploring Authenticity In Historical Fiction, Sarah E. Ray Nov 2025

With Love From The Front: Exploring Authenticity In Historical Fiction, Sarah E. Ray

Masters Theses

This MFA thesis is comprised of an artist statement, a scholarly essay on authenticity in WWII historical fiction, and a novel set during World War II. The artist statement outlines personal experiences, faith perspective, and writing aesthetics that shape the approach to historical storytelling, examining how a history-oriented upbringing and Christ-centered worldview inform a writing philosophy centered on crafting emotion through authentic character development and vivid sensory details. The scholarly component argues that authentic WWII fiction requires both meticulous historical accuracy and genuine emotional truth. Drawing on primary sources including interviews with former WWII Army members, wartime diaries, and period …


Chamber Music Recital: November 13, 2025, Illinois State University School Of Music Nov 2025

Chamber Music Recital: November 13, 2025, Illinois State University School Of Music

School of Music Programs

This is the fifty-first program of the 2025-2026 season.

Kemp Recital Hall

November 13, 2025

Thursday Evening

7:30 p.m.


Final Annual Operations And Maintenance (O&M) Report: Butte Treatment Lagoon (Btl) System – 2024, Pioneer Technical Services, Inc. Nov 2025

Final Annual Operations And Maintenance (O&M) Report: Butte Treatment Lagoon (Btl) System – 2024, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Holguin V. City Of Henderson, 141 Nev. Adv. Op. 53 (November 13, 2025), Francesca Manz Nov 2025

Holguin V. City Of Henderson, 141 Nev. Adv. Op. 53 (November 13, 2025), Francesca Manz

Nevada Supreme Court Summaries

Nevada Supreme Court holds that NRS 617.455 requires claimants to satisfy both the statutory exposure requirement and the conclusive presumption of work-relatedness to establish a compensable lung-disease claim.


State, Dep’T Of Corr. V. Dist. Ct., 141 Nev., Adv. Op. 54 (Nov. 13, 2025), Rocco Marino Nov 2025

State, Dep’T Of Corr. V. Dist. Ct., 141 Nev., Adv. Op. 54 (Nov. 13, 2025), Rocco Marino

Nevada Supreme Court Summaries

The exhaustion requirements of NRS 41.0322 and NRS 209.243 do not apply to the estates of deceased inmates.


Trypanosoma Cruzi Infection-Induced Changes In Cardiac Microvascular Endothelial Cell Morphology And Function, Lyndsey N. Gisclair, Douglas A. Johnston Nov 2025

Trypanosoma Cruzi Infection-Induced Changes In Cardiac Microvascular Endothelial Cell Morphology And Function, Lyndsey N. Gisclair, Douglas A. Johnston

School of Graduate Studies Faculty Publications

Introduction. Six to seven million individuals are infected with Trypanosoma cruzi, the causative agent of Chagas disease. With 12,000 deaths annually, chronic Chagas disease remains a significant global health challenge due to persistent vector transmission, increasing non-vector transmission and limited therapeutic options. Chronic Chagas cardiomyopathy is a leading cause of morbidity and mortality, yet the underlying mechanisms remain poorly understood.Gap Statement. Since its initial description more than 100 years ago, research efforts into the cardiomyopathy found in chronic Chagas disease have primarily focused on the contributions of immune cells, cardiomyocytes and cardiac fibroblasts, leaving a significant gap in understanding the …


Design, Optimization, And Development Of Ripk1 Degraders With Improved Pharmacokinetic And Pharmacodynamic Properties, Dong Lu, Xin Yu, Hanfeng Lin, Ran Cheng, Bin Yang, Min Zhang, Jingjing Chen, Feng Li, Xiaoli Qi, Jin Wang Nov 2025

Design, Optimization, And Development Of Ripk1 Degraders With Improved Pharmacokinetic And Pharmacodynamic Properties, Dong Lu, Xin Yu, Hanfeng Lin, Ran Cheng, Bin Yang, Min Zhang, Jingjing Chen, Feng Li, Xiaoli Qi, Jin Wang

Faculty, Staff and Students Publications

Pharmacological degradation of receptor-interacting protein kinase 1 (RIPK1) offers a compelling therapeutic strategy to overcome its scaffolding role in tumor resistance and to enhance the efficacy of immune checkpoint blockade (ICB) therapies. In this study, we report the discovery of a novel RIPK1 degrader, LD5097(24b), developed through systematic optimization of its precursor compound, LD4172—specifically refining the linker, RIPK1 warhead exit vector, and VHL ligand components. LD5097(24b) exhibits potent and selective RIPK1 degradation, triggering rapid and efficient downregulation of RIPK1 and significantly enhancing TNFα-mediated apoptosis in Jurkat cells. Compared to LD4172, LD5097(24b) demonstrates markedly improved metabolic stability and pharmacokinetic properties. In …


Collaborative Co-Design For Local Blue Food System Transformation:: The Practicalities And Challenges Of The Uk's (Foodsequal) 'Plymouth Fish Finger' Pilot Study, Louise Hunt, Clare Pettinger, Roussa Tsikritzi, Carol Wagstaff Nov 2025

Collaborative Co-Design For Local Blue Food System Transformation:: The Practicalities And Challenges Of The Uk's (Foodsequal) 'Plymouth Fish Finger' Pilot Study, Louise Hunt, Clare Pettinger, Roussa Tsikritzi, Carol Wagstaff

School of Health Professions

Purpose: UK food system transformation is urgently needed but blue foods (fish) have been only minimally part of this discourse. Informed by community action research in a UK southwest coastal city, fish was identified as a food commodity for food system innovation, leading to local collaborative ‘co-design’ of an iconic British food. The ‘Plymouth Fish Finger’ pilot assessed the practicalities and challenges of this social innovation and its provision into the school meal system. Design: Exploratory creative mixed methods mapped the journey of the Fish Finger as a social innovation. Methods drew on ‘co-production’ approaches, involving Community Food Researchers (CFR), …


Targeting Tomm40 And Tomm22 To Rescue Statin-Impaired Mitochondrial Function, Dynamics, And Mitophagy In Skeletal Myotubes, Neil V Yang, Sean Rogers, Rachel Guerra, Justin Y Chao, David J Pagliarini, Elizabeth Theusch, Ronald M Krauss Nov 2025

Targeting Tomm40 And Tomm22 To Rescue Statin-Impaired Mitochondrial Function, Dynamics, And Mitophagy In Skeletal Myotubes, Neil V Yang, Sean Rogers, Rachel Guerra, Justin Y Chao, David J Pagliarini, Elizabeth Theusch, Ronald M Krauss

2020-Current year OA Pubs

Statins are the drugs most commonly used for lowering plasma low-density lipoprotein (LDL) cholesterol levels and reducing cardiovascular disease risk. Although generally well-tolerated, statins can induce myopathy, a major cause of non-adherence to treatment. Impaired mitochondrial function has been implicated in the development of statin-induced myopathy, but the underlying mechanism remains unclear. We have shown that simvastatin downregulates the transcription of


U.S. West Consumer Preferences For Specialty Labeled Processed Foods, Kynda R. Curtis, Makaylie Langford, Karin E. Allen, Ruby Ward Nov 2025

U.S. West Consumer Preferences For Specialty Labeled Processed Foods, Kynda R. Curtis, Makaylie Langford, Karin E. Allen, Ruby Ward

All Current Publications

In the United States, consumer demand for specialty processed foods is increasingly centered on natural, organic, and local offerings that represent health and ethical values. This fact sheet provides an overview of a Utah State University study showing respondent preferences for specialty labeled processed foods. Specifically, consumer knowledge and familiarity with various specialty production and labeling programs, including organic, local, grass-fed, and non-GMO, were examined, along with specialty food consumption habits and attitudes. Finally, consumer pricing preferences for each of the three processed products examined are discussed. The information included in this fact sheet can be used by producers, food …


U.S. West Consumer Processed Food Preferences And Consumption Habits, Makaylie Langford, Kynda R. Curtis, Karin E. Allen, Ruby Ward Nov 2025

U.S. West Consumer Processed Food Preferences And Consumption Habits, Makaylie Langford, Kynda R. Curtis, Karin E. Allen, Ruby Ward

All Current Publications

This fact sheet provides an overview of study results, including respondent demographics, common lifestyle and food behaviors, product characteristics, labeling preferences, and processed food purchasing and consumption habits. Producers, food manufacturers, and processors can use the information included in this fact sheet to inform their decision-making related to product development, pricing, placement, and promotion. Additional fact sheets in this series examine consumer preferences and willingness to pay for specialty labeled foods, as well as the impact of providing labeling information. Three fact sheets discuss target markets or consumer groups for each of the processed products examined.


Culture-Independent Meta-Pangenomics Enabled By Long-Read Metagenomics Reveals Associations With Pediatric Undernutrition, Jeremiah J Minich, Nicholas Allsing, M Omar Din, Michael J Tisza, Kenneth Maleta, Daniel Mcdonald, Nolan Hartwick, Allen Mamerto, Caitriona Brennan, Lauren Hansen, Justin Shaffer, Emily R Murray, Tiffany Duong, Rob Knight, Kevin Stephenson, Mark J Manary, Todd P Michael Nov 2025

Culture-Independent Meta-Pangenomics Enabled By Long-Read Metagenomics Reveals Associations With Pediatric Undernutrition, Jeremiah J Minich, Nicholas Allsing, M Omar Din, Michael J Tisza, Kenneth Maleta, Daniel Mcdonald, Nolan Hartwick, Allen Mamerto, Caitriona Brennan, Lauren Hansen, Justin Shaffer, Emily R Murray, Tiffany Duong, Rob Knight, Kevin Stephenson, Mark J Manary, Todd P Michael

Faculty, Staff and Students Publications

The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enable pangenome and microbial genome-wide association study (GWAS) analyses to identify microbial genetic associations with child linear growth. LR methods produced 44-64× more cMAGs per gigabase pair (Gbp) than short-read methods, with PacBio (PB) yielding the most accurate and cost-effective assemblies. In a Malawian longitudinal pediatric cohort, we generated 986 cMAGs (839 circular) from 47 samples and applied this database to an expanded set of 210 samples. Machine learning identified species …


Lair1 Prevents Excess Inflammatory Tissue Damage In Staphylococcus Aureus Skin Infection And Cutaneous T-Cell Lymphoma, Hannah K. Dorando, Evan C. Mutic, Kelly L. Tomaszewski, Yulia Korshunova, Ling Tian, Mellisa K. Stefanov, Chaz C. Quinn, Deborah J. Veis, Juliane Bubeck Wardenburg, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton Nov 2025

Lair1 Prevents Excess Inflammatory Tissue Damage In Staphylococcus Aureus Skin Infection And Cutaneous T-Cell Lymphoma, Hannah K. Dorando, Evan C. Mutic, Kelly L. Tomaszewski, Yulia Korshunova, Ling Tian, Mellisa K. Stefanov, Chaz C. Quinn, Deborah J. Veis, Juliane Bubeck Wardenburg, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton

2020-Current year OA Pubs

Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to S. aureus skin infections and sepsis, but the underlying mechanisms remain unclear. We have previously identified high levels of LAIR2, a decoy protein for the inhibitory receptor LAIR1, in advanced CTCL. Mice lack a LAIR2 homolog, so we used Lair1 knock-out (KO) mice to model LAIR2 overexpression. In a model of S. aureus skin infection, Lair1 KO mice had significantly larger abscesses and areas of dermonecrosis compared to WT despite similar bacterial burdens. Lair1 KO exhibited a pattern of increased inflammatory responses in infection and sterile …


Culture-Independent Meta-Pangenomics Enabled By Long-Read Metagenomics Reveals Associations With Pediatric Undernutrition, Jeremiah J Minich, Nicholas Allsing, M Omar Din, Michael J Tisza, Kenneth Maleta, Daniel Mcdonald, Nolan Hartwick, Allen Mamerto, Caitriona Brennan, Lauren Hansen, Justin Shaffer, Emily R Murray, Tiffany Duong, Rob Knight, Kevin Stephenson, Mark J Manary, Todd P Michael Nov 2025

Culture-Independent Meta-Pangenomics Enabled By Long-Read Metagenomics Reveals Associations With Pediatric Undernutrition, Jeremiah J Minich, Nicholas Allsing, M Omar Din, Michael J Tisza, Kenneth Maleta, Daniel Mcdonald, Nolan Hartwick, Allen Mamerto, Caitriona Brennan, Lauren Hansen, Justin Shaffer, Emily R Murray, Tiffany Duong, Rob Knight, Kevin Stephenson, Mark J Manary, Todd P Michael

Faculty, Staff and Students Publications

The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enable pangenome and microbial genome-wide association study (GWAS) analyses to identify microbial genetic associations with child linear growth. LR methods produced 44-64× more cMAGs per gigabase pair (Gbp) than short-read methods, with PacBio (PB) yielding the most accurate and cost-effective assemblies. In a Malawian longitudinal pediatric cohort, we generated 986 cMAGs (839 circular) from 47 samples and applied this database to an expanded set of 210 samples. Machine learning identified species …