Digital Commons Network^™

Cordmilk: Umbilical Cord Milking Versus Early Cord Clamping On Short-And Long-Term Outcomes In Neonates Who Are Non-Vigorous At Birth-Study Protocol Of A Multi-Center, Cluster-Randomized, Crossover-Controlled Trial, S. Yogeshkumar, Sunil S. Vernekar, Sangappa M. Dhaded, Kiran Talekar, Benjamin E Leiby, Rebecca Hartman, Yvonne Vaucher, Nitin Chouthai, Meenakshi Girish, Manish Jain, Shuchi Jain, Seema Parvekar, Vinita Jain, Alka Patankar, Milind Suryawanshi, Manish Tiwari, Manjushri Waikar, Nidhi Nashine, Deepali Ambike, Mahesh Asalkar, Rajesh Kulkarni, Sandhya Haribhaktha, Hemraj Narkhede, Sudha Chaudhari, Milind Kamble, Deepti Shrirame, Balchandra Falke, Seema Mehta, Asha Verma, Sunil Gothwal, Shivaprasad S. Goudar, Richard Derman, Anup Katheria, Zubair H. Aghai

Department of Radiology Faculty Papers

BACKGROUND: Facilitating placental transfusion-the transfer of blood from the placenta to the newborn-via delayed cord clamping (DCC) or umbilical cord milking (UCM) at birth has been shown to improve iron stores in healthy term infants and may positively impact long-term neurodevelopmental outcomes. Infants who are non-vigorous at birth and at risk of developing hypoxic-ischemic encephalopathy (HIE) are particularly likely to benefit from placental transfusion. This process may offer neuroprotection by enhancing cardiopulmonary transition, supporting cardiac preload, improving systemic and cerebral perfusion, delivering stem cells and neurotrophic factors, and preventing iron deficiency. While DCC is not currently recommended for non-vigorous term …

Radiation Hardness Study Of Finfet And Gate-All-Around Fet Sram, Albert Lu

Master's Theses

Radiation, such as alpha particles or neutrons, is hard to control and can come from sources such as trace impurities or cosmic rays from space. These can then strike a semiconductor device, such as a Static Random Access Memory (SRAM) cell, and cause the SRAM to have its bit flipped. This bit flip is often just a temporary effect and is thus called a single event upset (SEU). Although it is temporary, a bit flip can cause severe consequences, such as affecting program functionality by causing incorrect data to be used. This is made worse in critical environments that need …

Conflicting Bases For Judging Action And Actors: The Role Of Individual Differences, Brittney Louramore

Electronic Theses and Dissertations

This study examined how political orientation, locus of control, and action identification predict moral reasoning across six dilemmas contrasting consistency and compensation. Participants (N ≈ 245) completed measures of ideological beliefs, perceived control, and action construal. Reliability analyses indicated modest internal consistency for Action Identification (α = .53) and low reliability for Locus of Control (α = .32). The six moral scenarios showed very low reliability (α = .11), indicating they captured diverse judgment domains. Binary logistic regressions revealed that political orientation, particularly its social dimension—was the strongest and most context-dependent predictor of moral choice. Economic …

Autostent: A Semi-Automated Approach To Designing Customized 3d-Printed Oral Radiation Stents For Patients With Head And Neck Cancer, Anshuman Agrawal, Rance B Tino, Mohamed Zaid, Millicent Roach, Lianchun Xiao, Mark S Chambers, Anna Lee, Eugene J Koay

Faculty, Staff and Student Publications

Background: Oral stents may reduce toxicities during radiation therapy for head and neck cancer (HNC). Customized 3D-printed oral stents offer faster production and achieve comparable patient-reported outcomes to conventionally fabricated stents. However, their design process remains time-consuming, lacks standardization, and relies heavily on skilled technicians. We hypothesized that semi-automating the design process for 3D-printed, mouth-opening, tongue-depressing (MOTD) stents could standardize the design workflow and decrease design time.

Methods: Using oral stent design principles established over decades by oral oncologists, we created a customized computer program (Autostent) using MATLAB to semi-automate the design process of MOTD stents. We subsequently compared Autostent …

Multiomic Analysis Reveals A Key Bcat1 Role In Mtor Activation By B Cell Receptor And Tlr9, Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Rahaman A Ahmed, Weixing Li, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicholas A Smith, Meng Li, Merrin Man Long Leong, Michael Lutchenkov, Jin Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael R Green, John M Asara, Adonia E Papathanassiu, Duane R Wesemann, Steven P Gygi, Vamsi K Mootha, Benjamin E Gewurz

Faculty, Staff and Student Publications

B lymphocytes play major adaptive immune roles, producing antibodies and driving T cell responses. However, how immunometabolism networks support B cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood. To gain insights, we systematically investigated acute primary human B cell transcriptional, translational, and metabolomic responses to B cell receptor (BCR), TLR9, CD40-ligand (CD40L), IL-4, or combinations thereof. T cell-independent BCR/TLR9 costimulation, which drives malignant and autoimmune B cell states, highly induced transaminase branched chain amino acid transaminase 1 (BCAT1), which localized to lysosomal membranes to support branched chain amino acid synthesis and mTORC1 activation. BCAT1 inhibition …

Machine Learning Model For Detecting Masked Hypertension In Young Adults, Brendyn Miller, Samuel Coeyman, Annemarie Wentzel, Carina M.C. Mels, William J. Richardson

Chemical Engineering Faculty Publications and Presentations

Introduction Cardiovascular disease (CVD) remains the leading global cause of mortality, with hypertension (HT) being a significant contributor, responsible for 56% of CVD-related deaths. Masked hypertension (MHT), a condition where patients exhibit normotensive blood pressure (BP) in clinical settings but elevated BP in out-of-clinic measurements, poses an elevated risk for cardiovascular complications and often goes undiagnosed. Current diagnostic methods, such as ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM), have limitations in feasibility and accessibility. Methods This study aimed to address these challenges by leveraging machine learning (ML) models to predict MHT based on clinical data from a single …

Marie Nelson Bennett, Myrna J. Layton

Faculty Publications

Marie Nelson Bennett (June 15, 1926 – November 18, 2018) was an American composer.

Cultural Innovation Can Increase And Maintain Biodiversity: A Case Study From Medieval Europe, Adam Spitzig, Manfred Rösch, Jessie Woodbridge, Martin Bauch, Piotr Guzowski, Peter Erhart, Ralph Fyfe, Elena Marinova, Adam Izdebski

School of Geography, Earth and Environmental Sciences

Numerous research efforts have used paleoecological data to reconstruct past biodiversity in Europe. In these projects, researchers have identified increases in biodiversity over the Holocene and hinted at a positive correlation with human population. These are important findings but are not easily translated into effective biodiversity conservation and restoration policy. We argue that, in order to better inform policymaking, studies of past biodiversity dynamics should include analyses of contemporaneous cultural phenomena in order to identify and describe specific anthropogenic drivers of past biodiversity changes. We present an example here, a case study from the Lake Constance region (southwestern Germany), one …

Re: Comment Letter For Diggings East 95 % Remedial Design Package Submittal (Dated August 29, 2025), The Silver Bow Creek Conservation Area (Sbcca) – 95 Percent Programmatic Technical Specifications Submittal (Dated August 19, 2025), The Draft Final Sbcca Construction Quality Assurance Plan (Dated August 20, 2025) And The Butte Priority Soils Sbcca Operations And Maintenance (O&M) Plan (Dated August 14, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Faculty Advisory Committee Minutes Of The Academic Senate 2025-11-17, University Of Dayton. Faculty Affairs Committee

All Committee Minutes

Approved minutes of a meeting of the Faculty Affairs Committee of the Academic Senate of the University of Dayton.

Academic Policies Committee Minutes Of The Academic Senate 2025-11-17, University Of Dayton. Academic Senate. Academic Policies Committee

All Committee Minutes

Approved minutes of a meeting of the Academic Policies Committee of the Academic Senate of the University of Dayton

Edwin F. Parry, Myrna J. Layton

Faculty Publications

Edwin Francis Parry (June 11, 1860 – September 16, 1935) was a Utah typesetter, printer and writer who also loved music. He sang, played the organ and piano, wrote song lyrics and composed many songs and hymns.

Irene (Christopherson) Tempest, Myrna J. Layton

Faculty Publications

Irene Ellen Nelson Christopherson Tempest (January 19, 1904 – February 9, 1988) was a Utah pianist, organist and composer.

Marie Manwaring Anderson, Myrna J. Layton

Faculty Publications

Teresa Marie Manwaring Anderson (July 8, 1913 – February 23, 2002) was an Idaho composer, pianist, music teacher and choral director.

Maurine Dewsnup, Myrna J. Layton

Faculty Publications

Grace Maurine Dewsnup (February 8, 1909 – February 1, 1998) was a Utah piano soloist, dance accompanist, composer, music theorist and teacher.

Water-Based Logic: The Water Heritage Of Greater Nanning And Its Role In Urban Authenticity, Tiansheng Li

Journal of Environmental Science and Sustainable Development

Water heritage plays a pivotal role in establishing Greater Nanning as a central city in the upper Pearl River basin of southern China. However, this heritage has largely been overlooked due to an urban narrative dominated by land-centrism. This article explores methods to create a comprehensive understanding of the water heritage of Greater Nanning and discusses how it can be integrated into the concept of urban authenticity. It argues that both tangible and intangible water heritages are essential elements to safeguard urban authenticity and promote sustainable cultural development. This study adopts an explanatory sequential mixed-methods design, combining quantitative analysis with …

Estrogen And Obesity Synergistically Suppress Protein S Via Hif1Α, Enhancing Thrombosis Potential, Mohammad A. Mohammad, Narender Kumar, Sonali Ghosh, Ashley L. Paysse, Claudia Leonardi, Vijaya Pilli, Ma Lorena Duhaylungsod, Eric Lazartigues, Diana Polania-Villanueva, Sadaf Nouman, Logan A. Barrios, Rima Chattopadhyay, Rafika Yasmin, Alaina Guilbeau, Manoj Kumar, Tina H. Nguyen, Jovanny Zabaleta, Li Li, Luis Del Valle M.D., Mallory T. Barbier, Samarpan Majumder, Laurent O. Mosnier, Samarpan Majumder

School of Graduate Studies Faculty Publications

Venous thromboembolism (VTE) is a leading cause of morbidity and mortality, with risk heightened in premenopausal women with obesity or use estrogen-based oral contraceptives. When both risk factors are present, the thrombosis risk increases substantially. Protein S (PS), an essential anticoagulant cofactor, is downregulated by both estrogen and obesity, but the molecular basis for this suppression remains poorly defined. We investigated the effect of estrogen and obesity on PS expression using plasma samples from 157 women stratified by BMI and contraceptive use, alongside 40 mice categorized as lean or obese with or without estrogen pellet treatment. The levels of PS …

Describing The Determinants Of Fluid Prescribing And Fluid Balance Optimization In The Pediatric Intensive Care Unit: A Qualitative Study At A Community Hospital, Salvador Roland Maffei, Graciela Sanabria, Matthew Pesek, Ayse Akcan-Arikan, Satid Thammasitboon, Patrick G Lyons

Faculty, Staff and Students Publications

Background: Critically ill children tend to receive fluid volumes exceeding physiologic requirements despite evidence demonstrating harm with increasing net positive fluid balance. However, interventions aimed at optimizing fluid balance have yet to demonstrate significant clinical benefit, likely because there are multiple drivers of this complex problem. In this study, we used qualitative inquiry to describe the current practice at a community pediatric intensive care unit and discover potential barriers and facilitators to clinical practice change.

Methods: We designed a semi-structured interview guide informed by the consolidated framework in implementation research (CFIR) and conducted interviews with attending physicians, dietitians, nurses, nurse …

Family Caregivers' Perspectives On Challenges And Support Needs In Hospital-Based Palliative Care For Persons Living With Dementia, Jung Kwak, Anita Chary, Sarah Stayer, Kwaku Duah Oppong, Sumin Yoon, Snehal Patel, Elizabeth A Kvale

Faculty, Staff and Students Publications

Palliative care needs of hospitalized persons living with dementia (PLWD) and their family caregivers remain poorly understood. This mixed-methods study explored caregivers' perspectives on challenges and support needs when hospitalized PLWD received specialist palliative care consultations. Thirty-two caregivers were recruited from two hospitals; 18 completed interviews and surveys, and 14 completed surveys only. Participants were racially and ethnically diverse (19% Black or African American, 34% Latino or Hispanic). Most identified as women (65%) and adult children (56%). Commonly reported challenges included managing health issues (59%), emotional distress (56%), and decision-making (47%). Thematic analysis of interviews revealed three themes: the value …

Comparing Diagnostic Tools For Heart Failure With Preserved Ejection Fraction Across Community And Clinical Cohorts, Luca Monzo, Olivier Huttin, Biykem Bozkurt, Kévin Duarte, Cecilia Linde, Lars H Lund, Camilla Hage, Erwan Donal, Martin Magnusson, Peter Nilsson, Margret Leosdottir, Erwan Bozec, Guillaume Baudry, Faiez Zannad, Nicolas Girerd

Faculty, Staff and Students Publications

Background: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging, particularly in older adults. While the Heart Failure Association (HFA)-PEFF and H2FPEF Scores offer structured diagnostic approaches, their clinical utility is still debated. This study aims to compare the diagnostic accuracy of HFpEF Scores versus inclusion criteria used in sodium-glucose cotransporter-2 inhibitors (SGLT2i) trials, age-adjusted N-terminal pro B-type natriuretic peptide (NT-proBNP) thresholds and the universal definition of heart failure (HF).

Methods: Diagnostic tools were assessed using sex-weighted and age-weighted propensity score adjustment in individuals aged 60-80 years from two established HFpEF cohorts (MEtabolic Road to DIAstolic Heart Failure (MEDIA), …

Strategies To Improve Healthcare Team Communication Structure And Quality In Resource-Variable Childhood Cancer Hospitals (Teamtalk): A Study Protocol, Asya Agulnik, Dylan E Graetz, Bobbi J Carothers, Jocelyn Rivera, Erin Abu-Rish Blakeney, Samantha Hayes, Veronica L Chaitan, Leopoldo Cabassa, Charles W Goss, Douglas A Luke, Sara Malone

2020-Current year OA Pubs

BACKGROUND: Healthcare team communication is essential to high-quality childhood cancer care, especially during high-acuity events such as clinical deterioration and in resource-variable settings, where supportive interventions to resolve deterioration are less available. Communication quality has traditionally been understudied in these settings, and there is a notable lack of communication interventions that are appropriate and feasible in settings across resource levels. We propose addressing this challenge in this study protocol, which will co-develop and pilot a multi-level intervention to improve communication and outcomes for children receiving cancer treatment.

METHODS/DESIGN: This study leverages systems and implementation science methodologies to evaluate and improve …

Disinhibited Behavior Associated With Rapid Clinical Response To Deep Brain Stimulation For Obsessive-Compulsive Disorder: Illustrative Cases, Sarah S Soubra, Tommy B Liu, Zain U Naqvi, Thomas Hamre, Danika L Paulo, Kalman A Katlowitz, Nisha Giridharan, Katie Van Arsdel, Jonathan H Bentley, Kasra A Mansourian, Davin Devara, Eric A Storch, Sarah R Heilbronner, Sameer A Sheth, Wayne Goodman, Nicole R Provenza

Faculty, Staff and Students Publications

Background: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) can alleviate symptoms of obsessive-compulsive disorder (OCD) refractory to conventional therapies. Overstimulation, however, can elicit pathological behaviors marked by disinhibition and recklessness.

Observations: Two patients with OCD underwent DBS of the VC/VS region and met responder status within 1 month of stimulation onset, as evidenced by a ≥ 35% reduction in their Yale-Brown Obsessive Compulsive Scale score. Notably, both patients exhibited signs of disinhibited behavior soon after DBS activation, including gambling, sleep disruption, and interpersonal relationship volatility. Through careful management, responder status persisted stably beyond the transient period of …

High-Sensitivity Plasma Proteomics Reveals Disease-Specific Signatures And Predictive Biomarkers Of Alzheimer's Disease Phenotypes In A Large Mixed-Dementia Cohort, Katherine Gong, Jigyasha Timsina, Muhammad Ali, Yike Chen, Menghan Liu, Ciyang Wang, Cyril Pottier, Geoffrey K Feld, Gyujin Heo, Tammie L S Benzinger, Cyrus A Raji, Beau Ances, Brian A Gordon, Julie K Wisch, Suzanne E Schindler, John C Morris, David M Holtzman, Laura Ibanez, Carlos Cruchaga

2020-Current year OA Pubs

Novel plasma assays enabled accurate blood-based biomarkers for neurodegenerative diseases with minimally invasive options for clinical use. Large-scale studies encompassing multiple neurodegenerative diseases using novel multiplex platforms are essential to uncover disease-specific biomarkers and pathways. We generated and analyzed plasma biomarker data using the NULISAseq™ CNS Panel from 3,232 participants with Alzheimer disease (AD), Dementia with Lewy bodies (DLB), Frontotemporal dementia (FTD), Parkinson disease (PD) and cognitively unimpaired individuals, from the Charles F. and Joanne Knight Alzheimer Disease Research Center. We identified proteins associated with disease status and AD-related phenotypes (Clinical Dementia Rating®, CSF Aβ42/Aβ40, Amyloid-PET, and Tau-PET). These proteins …

Dietary Sources Of Sodium Intake In Nigerian Adults: A Population-Based Cross-Sectional Study, Clementina E Okoro, Erica L Jamro, Guhan Iyer, Mark D Huffman, Et Al.

2020-Current year OA Pubs

Nigeria seeks to address the growing burden of hypertension and related diseases by reducing excessive dietary sodium through national dietary policymaking. This study aims to describe the levels and sources of dietary sodium intake among Nigerian adults to inform these policies. From June 2023 to July 2023, adults aged 18 to 69 years old were recruited from the Federal Capital Territory, Kano, and Ogun states to participate in a population-based, cross-sectional demographic health survey. Data were also collected to assess levels and dietary sources of sodium through four 24-h dietary recalls by trained study personnel. The primary analyses included the …

A Comprehensive Review Of Influence Of Critical Parameters On Wettability Of Rock-Hydrogen-Brine Systems: Implications For Underground Hydrogen Storage, Nurudeen Yekeen, Berihun Mamo Negash, Muhammad Ali, Ahmed Al-Yaseri, Surajudeen Sikiru

Research outputs 2022 to 2026

The rock wettability is one of the most critical parameters that influences rock storage potential, trapping, and H2 withdrawal rate during Underground hydrogen storage (UHS). However, the existing review articles on wettability of H2-brine-rock systems do not provide detailed information on complexities introduced by reservoir wettability influencing parameters, such as high pressure, temperature, salinity conditions, micro-biotic effects, cushion gases, and organic acids relevant to subsurface environments. Therefore, a comprehensive review of existing research on various parameters influencing rock wettability during UHS and residual trapping of H2 was conducted in this study. Literature that provides insight into molecular-level interaction through machine …

The “I’M Too Much, Yet Never Enough” Paradox: A Critical Approach To Discourses Of Afro-Latinidad Among Second-Generation-Immigrant Women In South Florida, Eleni Victoria Webster

Electronic Theses and Dissertations

This study critically examines discourse and the ways it shapes identities and community belonging for self-identifying Afro-Latina, second-generation-immigrant women in South Florida. This qualitative research uses an intercultural communication framework to analyze interviews and collected poems. Informed by grounded theory and a Black feminist critical approach rooted in the intersectionality theory, the data is analyzed through comparative thematic and metaphorical rhetorical analyses. When discussing the discourses related to the development of ethno-racial identities for Afro-Latinas, certain communicative patterns of self-discovering, self-defining, and self-envisioning emerged. With regard to community belonging, three metaphorical discourses arose: not-enoughness, in-betweenness, and un-humanness. The internalization of …

Application Of Freezetb, A Targeted Nanopore Sequencing Assay, For Identification Of Drug Resistance And Lineages Among Pulmonary Tuberculosis Cases In Alaska, Bryce Inman, Jeremy Butler, Soren George-Nichol, Ganna Kovalenko, Theresa Savidge, Yvette Vergnetti, Catherine Pongratz, Elizabeth Bee, Andrew R Dinardo, Alexander Kay, Anna Mandalakas, Eric Bortz, Tara E Ness

Faculty, Staff and Students Publications

Alaska has the highest incidence of tuberculosis (TB) in the United States, with 8% mortality while undergoing TB treatment. With a quarter of TB cases lacking sputum culture to enable drug resistance testing, FreezeTB aimed to develop tools tailored to meet the challenges in Alaska while being translatable to other settings. We designed a rapid and cost-effective laboratory workflow and software to identify drug-resistant mutations in Mycobacterium tuberculosis using targeted next-generation sequencing (tNGS). FreezeTB, a Fast, Reliable, Economical Evaluation tool to Zap Endemic Tuberculosis, amplifies 22 gene loci associated with resistance to 16 anti-tuberculosis drugs. M. tuberculosis isolates from Alaska …

Developing A Genetic Return Of Results Service Core, Jennifer A Mckenzie, Erin Mcroy, Kevin M Bowling, Jorge Luis Granadillo De Luque, Jessica Mozersky, Erin Linnenbringer, Dustin Baldridge, Jonathan W Heusel, Julie A Neidich, Amanda F Cashen, Laura J Bierut, Sarah M Hartz, Christina A Gurnett

2020-Current year OA Pubs

Research participants should be informed of genetic test results that could impact their health, particularly when they have expressed interest in receiving such information. Furthermore, the return of genetic test results is essential to improve trust, transparency, and health equity. However, investigators often encounter barriers in returning genetic test results to research participants. We examined genomic research at a large, research-intensive medical school and found less than 6% of protocols included plans to return results to participants. This study describes our development of protocols for returning primary and secondary genetic test results and implementation of a Genomic Return of Results …

Ptbp1 Variants Displaying Altered Nucleocytoplasmic Distribution Are Responsible For A Neurodevelopmental Disorder With Skeletal Dysplasia, Aymeric Masson, Catherine Gooch, Et Al.

2020-Current year OA Pubs

Polypyrimidine tract-binding protein 1 (PTBP1) is a heterogeneous nuclear ribonucleoprotein primarily known for its alternative splicing activity. It shuttles between the nucleus and cytoplasm via partially overlapping N-terminal nuclear localization (NLS) and export (NES) signals. Despite its fundamental role in cell growth and differentiation, its involvement in human disease remains poorly understood. We identified 27 individuals from 25 families harboring de novo or inherited pathogenic variants - predominantly start-loss (89%) and, to a lesser extent, missense (11%) - affecting NES/NLS motifs. Affected individuals presented with a syndromic neurodevelopmental disorder and variable skeletal dysplasia with disproportionate short stature with short limbs. …

Evaluating Semantic Representations In Multimodal Word Grounding, Saima Shaukat, Amir Aly, Thomas Wennekers, Angelo Cangelosi

School of Engineering, Computing and Mathematics

Word grounding tasks aim to associate individual words withcorresponding elements in visual scenes, enabling machines to link language with perception for effective human–machine interaction. However,existing grounding models struggle to generalize to synonyms or unseenlexical variants, limiting their performance in open-domain scenarios. Inthis paper, we present a Bayesian multimodal grounding model that incorporates word embeddings as priors within a probabilistic generativeprocess to improve robustness under lexical variation. We compare theeffects of static FastText and contextual BERT embeddings on grounding accuracy by conditioning word–visual associations on their semanticrepresentations. Experiments use CLEVR-generated 3D scenes pairedwith structured compositional descriptions to test the grounding of …