Digital Commons Network^™

Llm-Driven Semantic Explanations For Soil Moisture Prediction Models, Bamory Ahmed Toru Koné, Khouloud Boukadi, Rima Grati, Emna Ben Abdallah, Massimo Mecella

All Works

Efficient soil moisture prediction is crucial for sustainable agricultural practices, especially in the face of climate change and increasing water scarcity. However, the adoption of machine learning (ML) models in this context is frequently limited by their lack of interpretability, particularly among non-expert users such as farmers. This study proposes a novel approach to soil moisture prediction that combines high predictive performance with enhanced explainability. We propose a framework that leverages large language models (LLMs) to generate textual explanations based on a proposed irrigation and soil moisture ontology, thus making the model's predictions more understandable to farmers. The ontology formalizes …

Atheist Values And The Religious Other: Negotiating Morality In Indonesia, Malaysia, And The Philippines, Timo Duile, Prince Kennex R. Aldama

Antropologi Indonesia

As being religious is often seen in religious societies as a precondition for having values, atheists often face prejudice as they are seen as people without values. However, as they conceptualize and construct their values with and against the religious other, they are part of society as an arena in which what counts as values is constantly negotiated. Drawing on David Graeber’s concept of society as an arena for the realization of value production, this article sheds light on the values of atheists in religious plural societies in Southeast Asia, namely Indonesia, Malaysia, and the Philippines. It analyzes how atheism …

Advancing Environmental Sustainability In The Uae: The Interplay Of Women’S Empowerment, Financial Development, And Natural Resource Management, Suzanna Elmassah, Eslam A. Hassanein

All Works

This study addresses a critical gap in the literature by exploring the intricate relationships between women’s empowerment, financial development, and natural resource management within the context of environmental sustainability in the United Arab Emirates (UAE). Utilizing the Women, Business, and Law Index to quantify women’s socioeconomic empowerment alongside the ecological footprint as a metric for environmental sustainability, this study employs an autoregressive distributed lag (ARDL) model to analyze data from 1990 to 2021. The findings reveal that women’s empowerment exerts a significant positive effect on environmental sustainability in both the short and long term. While financial development and natural resource …

Genomic And Functional Characterisation Of Endophytic Bacterium Bacillus Cereus Strain E1 Alleviating Salt Stress And Enhancing Tomato Physiology And Spectral Indices, Balamurugan Sadaiappan, Tanveer Alam Khan, Qurban Ali, Sulamita Santos Correa, Mahideen Afridi, Soumaya Tounsi Hammami, Munawwar Ali Khan, Sunil Mundra

All Works

Mangroves in arid environments represent unique ecological niches that support a diverse range of microorganisms. Endophytic bacteria residing within host plants play a crucial role in promoting plant growth by enhancing pathogen resistance and alleviating environmental stress. Identifying novel stress-tolerant strains, specific to arid environments, is essential for expanding the repertoire of plant growth-promoting bacteria (PGPB). In this study, we investigated the saline tolerance of the endophytic bacterium strain E1, previously isolated from the root of Avicenna marina (grey mangrove). Whole-genome sequence (WGS), phylogenetics and average nucleotide identity (ANI) analysis were performed. The strain exhibited high salinity tolerance, growing in …

A Critical Policy Analysis Of Dual Language Education Policies On The Equity And Opportunity Of Participation And Access For Multilingual Learners, Justin A. Andersen

All Graduate Theses and Dissertations, Fall 2023 to Present

Dual Language Immersion programs help students become fluent in two languages while achieving academic success. Originally designed to support students who speak languages other than English at home, these programs have grown rapidly across Utah and the U.S. However, they increasingly serve white, English-speaking families seeking enrichment opportunities, while multilingual students who could benefit most remain underrepresented.

This study examined recruitment and admissions policies in two Utah school districts’ dual language programs. By comparing policy documents, analyzing enrollment data, and interviewing district staff, school leaders, and parents, the research revealed significant implementation differences despite identical statewide program requirements.

One district …

Breaking The Silence With Routine Genitourinary Syndrome Of Menopause Screening: A Quality Improvement Project, Ashley R. Noel

Electronic Theses and Dissertations

Affecting upwards of 87% of women in post menopause, genitourinary syndrome of menopause is greatly under-diagnosed, and consequently, under-treated. Genitourinary syndrome of menopause refers to health conditions impacted by hypoestrogenic state experienced in menopause. Common symptoms of GSM include vaginal dryness, irritation, clitoral or labial atrophy, dyspareunia, decreased libido, anorgasmia, dysuria, recurrent UTI, urinary incontinence (Kaufman et al., 2025). Despite the burdensome consequences of GSM, women are unlikely to vocalize their symptoms and seek treatment. Additionally, societal beliefs of shame surrounding sexual health impede patients and clinicians from addressing GSM specifically (Mili et al., 2021). As a result, the North …

Improving Intimate Partner Violence Screening In Telehealth Mental Health Settings, Marina Oliynyk

Electronic Theses and Dissertations

Intimate partner violence (IPV) is a pervasive yet frequently underrecognized public health concern, particularly within telehealth psychiatric care, where nonverbal cues may be absent. This quality improvement (QI) project aimed to improve the identification and response to IPV by implementing a standardized, evidence-based screening protocol in a private telepsychiatry practice. Guided by the Plan-Do-Study-Act (PDSA) framework, the validated E-HITS screening tool was introduced, along with structured trauma-informed care training, to six psychiatric-mental health nurse practitioners (PMHNPs). Six PMHNPs completed pre/post-confidence surveys (5-point Likert) and tracked screening activity across 100 telehealth encounters (98 of 100 visit were eligible). Over a three-month …

Enhanced Photovoltaic Performance Of Silicon Solar Cells Via Plasma-Deposited Antireflective Titanium Dioxide Coatings, Saad Tuama, Omar Abdulrazzaq, Noor Nasir, Alaa Saloom, Muatez Mohammed

Journal of Applied Sciences and Nanotechnology

A cost-effective DC glow discharge plasma system was used to deposit a 75 nm titanium dioxide (TiO2) antireflective coating on 5 cm2 crystalline silicon solar cells (initial efficiency 10.13%). The plasma-deposited TiO2 film was nanocrystalline: X-ray diffraction revealed mixed anatase/rutile phases with an average crystallite size of ≈17.6 nm and an optical band gap Eg ≈ 3.5 eV. Atomic force microscopy (AFM) showed a granular surface with average roughness Ra ≈50.7 nm (Rq ≈ 67.7 nm) and grain size ≈ 13.1 nm. Optical reflectance measurements indicated a significant reduction in surface reflectance across the visible spectrum after coating, consistent with …

Electrochemical Aspect Of Protection Reinforced Steel Bar By Copper Coating Via Modified Rolling Technique, Sana Hameed, Rana Anaee, Ahmed Al-Ghaban, Hussain Yousif

Journal of Applied Sciences and Nanotechnology

This study investigates the corrosion resistance of copper-coated reinforcing steel bars embedded in concrete and exposed to a simulated marine environment for (28, 56, and 90 days) at temperatures of (298, 308, and 318 Kelvin). A novel thermal spray technique was integrated into the hot rolling process to deposit copper powder onto heated steel bars. The coated bars were characterized using X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive spectroscopy (SEM/EDS), and atomic force microscopy (AFM), revealing a dense, uniform microstructure with reduced surface roughness (63.99 nm) and increased particle density (〖30.2 ×10〗^6 particles/mm²) compared to the uncoated steel bar. …

An Attack-Centric Approach To Security, Privacy, And Legal Challenges In Virtual Healthcare, Suvineetha Herath

Masters Theses & Doctoral Dissertations

As the U.S. healthcare sector continues to evolve, the adoption of virtual care delivery systems has expanded rapidly. This digital transformation has intensified concerns regarding the security and privacy of Protected Health Information (PHI). To address these challenges, this study employed a sequential, exploratory mixed-methods approach to examine the evolving threat landscape and to develop an attack-centric threat model for virtual healthcare environments. In the first phase, a qualitative analysis of regulatory enforcement and legal effectiveness was conducted to examine compliance gaps, privacy risks, and legal consequences within virtual healthcare systems. Building on the qualitative findings, the second phase quantitatively …

Applying Ni-Wc As A Composite Coating Combines Both Protective And Repair Functions By Thermal Spray For Hptb Applications, Alaa Dahesh, Ahmed Hassan, Hussain Yousif

Journal of Applied Sciences and Nanotechnology

This work presents a solution to repair the deteriorating High-Pressure Turbine Blades (HPTB) instead of costly replacement by implementing a two-coating layer system for protection and repair. The first layer is a Bonding Coating (BC) that is made from a nickel-based alloy (NiCrBSi); the second layer is a Top Coating (TC), which is composed of a nickel-based composite material that contains tungsten carbide (WC) particles. Both layers were applied to a nickel-based substrate using a flame thermal spraying (FTHS) technique, with the spray parameters chosen based on the Taguchi method. The results were analyzed using optical microscopy, scanning electron microscopy …

Sztuczna Inteligencja W Systemach Informatycznych Zarządzania W Środowisku Procesowym, Małgorzata Oleś-Filiks

Monografie/Monographs

Współczesne systemy informacyjne zarządzania wraz z procesami biznesowymi odgrywają kluczową rolę w funkcjonowaniu organizacji, wspierając zarówno codzienne operacje, jak i podejmowanie strategicznych decyzji. Monografia przybliża problematykę integracji sztucznej inteligencji z wybranymi typami systemów informatycznych zarządzania ze szczególnym uwzględnieniem Business Process Management jako środowiska sprzyjającego implementacji sztucznej inteligencji jako narzędzia wspomagającego sterowanie, analizę i optymalizację procesów biznesowych. Szeroko prezentuje m.in. typy systemów informacyjnych zarządzania, w których wdrożenie AI przynosi największe korzyści, ze szczególnym uwzględnieniem Business Process Management jako środowiska, w którym sztuczna inteligencja może być skutecznie osadzona jako komponent sterujący i analityczny.

Artificial Intelligence in IT Management Systems in a Process …

Heartmath: A Stress Reduction Program For Healthcare Providers In An Addiction Treatment Setting, Dihana C. Ruiz

Electronic Theses and Dissertations

Work-related stress significantly impacts the well-being of healthcare providers, specifically nurses and nurse practitioners, in addiction treatment facilities. This Quality Improvement (QI) project implemented the HeartMath Quick Coherence Technique to reduce stress and enhance resilience among staff, thereby improving the well-being of healthcare providers and the quality of care. The project utilized a pre- and post-intervention design with five participants, two registered nurses, and three nurse practitioners. Participants received training on HeartMath techniques, the EmWave Pro sensor, and the InnerBalance smartphone application. Over a six-week period, participants practiced Quick Coherence meditation for five minutes, twice daily, to achieve heart rate …

Safety In Stability: A Cdc-Guided Evaluation Of Hospital Fall Prevention Practices, Matthew C. Dougherty

Electronic Theses and Dissertations

Hospital falls remain a persistent and preventable cause of patient harm, emphasizing the need for continuous evaluation of fall prevention practices. This project assessed the effectiveness of AdventHealth Orlando’s fall prevention policy using the Centers for Disease Control and Prevention (CDC) Program Evaluation Framework. A mixed-methods design incorporated quantitative analysis of 12 months of fall data and qualitative feedback from frontline staff surveys and discussions. Results demonstrated a decrease in total falls from 549 in the previous year to 528 in the current year, indicating early progress despite the incomplete reporting period. Unit-level analysis showed a mean improvement of 16.9% …

Enhancing Provider Knowledge And Implementation Of Medication For Opioid Use Disorder (Moud) To Improve Treatment Outcomes: A Quality Improvement Project., Motunrayo Abigael Ibraheem

Electronic Theses and Dissertations

This quality improvement project sought to enhance healthcare providers' knowledge and attitudes toward Medication for Opioid Use Disorder (MOUD) at Galt Ocean Rehab Center to improve treatment outcomes for patients with opioid use disorder. Despite evidence supporting the efficacy of MOUD, significant knowledge gaps and stigmatizing attitudes among providers create barriers to optimal care. Sixteen healthcare providers participated in a comprehensive educational intervention grounded in Jean Watson's Theory of Transpersonal Caring and the Institute for Healthcare Improvement's Model for Improvement. The intervention consisted of a 4-hour workshop, six weekly reinforcement sessions, and the implementation of standardized buprenorphine management protocols. Pre- …

Enhancing Td Screening With The Aims Scale: A Quality Improvement Project, Dionne Smith

Electronic Theses and Dissertations

Tardive dyskinesia (TD) is a persistent, often irreversible movement disorder associated with long-term use of dopamine receptor–blocking agents. Early identification is critical to prevent progression and minimize functional impairment; however, routine TD screening remains inconsistent in many clinical settings despite the availability of the Abnormal Involuntary Movement Scale (AIMS), the evidence-based gold-standard tool. This quality improvement project aimed to enhance TD screening in an outpatient psychiatric setting through an educational intervention designed to improve provider knowledge of risk factors, diagnostic criteria, and screening guidelines. Data were collected retrospectively and prospectively from patient encounters, with 33 pre-intervention and 35 post-interventions. AIMS …

Assembling Life From Death: Examining The Archaeological Fauna Of Jupiter Inlet Lighthouse’S Past To Preserve Biodiversity For The Future, Victoria Sherwood

Electronic Theses and Dissertations

This project utilizes an assemblage of faunal remains from a precontact midden at the Jupiter Inlet Lighthouse archaeological site in northern Palm Beach County, Florida. The assemblage was identified and analyzed through the lenses of resource use and paleoenvironmental changes. The Indigenous groups in the area heavily utilized estuarine resources such as fish and marine turtles. The archaeological assemblage was compared to a modern survey of species present at the site. The species identified in the precontact collection are present in the surrounding area today. The archaeological assemblage matching up with modern species speaks to the success of Loxahatchee River …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

High-Risk Medications In Pediatric Dentistry: Patterns, Outcomes, And Clinical Implications, Yilei Liu, Kawtar Zouaidi, Colin C Hubbard, Muhammad F Walji, Matthew R Cooke, Donald B Rindal, Kristin N Ray, Elsbeth Kalenderian, Katie J Suda

Faculty, Staff and Student Publications

Background: High-risk medications such as opioids and benzodiazepines are frequently prescribed in pediatric dental care, yet their prescribing patterns and associated adverse outcomes remain poorly understood. The aim of this study was to determine the extent of such prescribing to pediatric patients and factors associated with adverse outcomes.

Methods: MarketScan data for patients younger than 18 years with a dental visit from 2014 through 2019 were analyzed. High-risk medications included benzodiazepines, barbiturates, and opioids. Composite outcomes included hospitalization, emergency department visit, or urgent care visit within 7 days after the dental visit. Opioid-attributable outcomes included opioid-related overdose within 7 days …

Alk5 Inhibitor Impact On Bleomycin-Induced Systemic Sclerosis Mouse Model Via Multifunctional Optical Coherence Tomography, Pavel V Nikitin, Harshdeep S Chawla, Jessica Gutierrez, Geethangili Madamanchi, Manmohan Singh, Salavat R Aglyamov, Minghua Wu, Jerry Alonso, Matthew Fronheiser, Juliana Coculo, Shuyan Du, Shervin Assassi, Kirill V Larin

Faculty, Staff and Student Publications

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis, vascular dysfunction, and immune dysregulation, leading to significant morbidity and mortality. Noninvasive imaging techniques are critical for monitoring disease progression and evaluating therapeutic interventions. This study investigates the technical feasibility of multifunctional optical coherence tomography (OCT)-based methods for longitudinal assessment of skin thickness, stiffness, and microvasculature in a murine SSc model as a translational, noninvasive, and quantitative method to study disease progression and treatment response. Our findings demonstrate significant structural, biomechanical, and vascular changes in the skin's stiffness, indicative of fibrosis, a hallmark of SSc. The application of SB …

Fam13a Polymorphism Is Associated With A Usual Interstitial Pneumonia Pattern In Patients With Systemic Sclerosis-Associated Interstitial Lung Disease, Elana J Bernstein, Francesco Boin, Brett Elicker, Yiming Luo, Yawen Ren, Meng Zhang, John Varga, Shervin Assassi

Faculty, Staff and Student Publications

Objectives: The MUC5B promoter single nucleotide polymorphism (SNP) rs35705950 has been associated with idiopathic pulmonary fibrosis (IPF) and RA-related interstitial lung disease (ILD), but not with SSc-ILD. We hypothesized that the MUC5B promoter polymorphism or other IPF susceptibility loci are associated with an increased risk for the uncommon SSc-usual interstitial pneumonia (UIP) endophenotype, rather than SSc-ILD in general.

Methods: We performed a cross-sectional study of SSc-ILD patients from four US Scleroderma Programs to investigate the frequency of MUC5B rs35705950 and 12 additional IPF susceptibility loci. SSc-ILD patients were stratified by high resolution chest CT (HRCT) imaging findings into UIP and …

Nocturnal Oxygen Therapy For Central Sleep Apnea In Patients With Heart Failure: A Multisite, Double-Blind, Sham-Controlled Randomized Clinical Trial (Loft-Hf), Susan Redline, Dongdong Li, Shahrokh Javaheri, Sanjay R Patel, Sairam Parthasarathy, James C Fang, Lee K Brown, Mark Dunlap, M Safwan Badr, Neomi Shah, Luqi Chi, Ruckshanda Majid, Mihaela Teodorescu, Garrick Stewart, Eileen Hsich, Tamar Polonsky, Justin Vader, Maryl R Johnson, Dennis Auckley, Henry Klar Yaggi, Andrew Kao, Ali Azarbarzin, Raichel Alex, Michael Rueschman, Lisa Wolfe, Daniel J Gottlieb, Scott A Sands, Phyllis C Zee, Reena Mehra, Babak Mokhlesi, Rami Khayat, Eldrin F Lewis, William T Abraham, Rui Wang

Faculty, Staff and Student Publications

Rationale: There are insufficient data to inform the management of central sleep apnea (CSA) in patients with heart failure with reduced ejection fraction (HFrEF). Nocturnal oxygen therapy (NOT) has been postulated to benefit CSA patients with HFrEF but has not been rigorously studied. Objectives: To compare NOT with sham NOT (control) in heart failure (HF) patients receiving guideline-based HF therapy on the composite outcome of first occurrence of either mortality due to any cause, a lifesaving cardiovascular intervention, or an unplanned hospitalization for worsening HF, together with other secondary outcomes.

Methods: A multisite, double-blind, sham-controlled randomized clinical trial was conducted …

Combining Pirfenidone With Mycophenolate Mofetil For Systemic Sclerosis-Related Interstitial Lung Disease (Scleroderma Lung Study Iii): An Investigator-Initiated, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial, Dinesh Khanna, Cathie Spino, Donald P Tashkin, Elana J Bernstein, Jonathan Goldin, Eric C Kleerup, Airi Harui, Grace Ibrahim, Grace Hyun J Kim, Suiyuan Huang, Richard Mclain, Yi-Hsuan Tu, Vivek Nagaraja, Richard M Silver, Virginia D Steen, S Samuel Weigt, Joyce S Lee, Aryeh Fischer, Mary Beth Scholand, Jessica K Gordon, Paul F Dellaripa, Ivan O Rosas, Gary M Hunninghake, Marcin A Trojanowski, Robert W Simms, Jane E Dematte, Vivien M Hsu, Robyn T Domsic, Ganesh Raghu, Maureen D Mayes, Ryan D Boente, Michael D Roth

Faculty, Staff and Student Publications

Objective: Mycophenolate mofetil (MMF) can stabilize or improve lung function in systemic sclerosis-related interstitial lung disease (SSc-ILD). We hypothesized that combining MMF with pirfenidone (PFD) would produce a significantly more rapid and/or greater improvement in lung function.

Methods: A randomized (1:1), double-blind, placebo (PLA)-controlled phase 2 trial was conducted in SSc-ILD in which patients received PFD or PLA (801 mg three times daily) along with MMF (1,500 mg twice daily) for 18 months. The primary outcome was change in percent predicted forced vital capacity (FVC-%). Linear mixed-effects models assessed treatment differences in a modified intention-to-treat population.

Results: Only fifty-one of …

Revisiting Soluble Guanylate Cyclase Pharmacology: Additive Potential Of Stimulators And Activators, Alexandra Petraina, Mahmoud H Elbatreek, Christopher T Neullens, Theodora Saridaki, Vu Thao-Vi Dao, Rebecca D Szepanowski, Emil Martin, Wolfgang Sippl, Ana I Casas, Harald H H W Schmidt

Faculty, Staff and Student Publications

Nitric oxide (NO) is a key gasotransmitter that binds to soluble guanylate cyclase (sGC), thereby stimulating cGMP production. Under disease conditions, reactive oxygen species disrupt this signaling by either: (1) scavenging NO, or (2) promoting heme-free, NO-insensitive apo-sGC due to impaired heme incorporation or oxidative damage. To counteract these conditions, two pharmacological approaches have emerged: sGC stimulators, which allosterically enhance sGC sensitivity to low NO levels; and sGC activators, which directly activate apo-sGC (heme-free sGC) by binding to its empty heme pocket, inducing a conformation that mimics NO-bound sGC. Thus, sGC stimulators are thought to target only sGC. Instead, we …

A Urine-Based Point-Of-Care Test For Factor Xa Inhibitors In Acute Stroke Management, Prasen R Marella, Jacob A Sambursky, Kriti Bhayana, Asha P Jacob, Varsha Muddasani, Murli Mishra, Alexandra L Czap, James C Grotta

Faculty, Staff and Student Publications

Background: For stroke patients with history of possible Direct Acting Oral Anticoagulant use, clinicians must make treatment decisions without knowledge of whether the patient is therapeutically anticoagulated. A urine-based point-of-care test might help guide these emergency decisions.

Methods: We prospectively enrolled patients with suspected recent factor-Xa-inhibitor (Xai) use being evaluated for acute stroke therapy in an urban teaching hospital. We obtained the urine test and plasma anti-Xa level in parallel with usual clinical management; the treating clinician did not use test results for decision-making but recorded treatment they would have given had they known the urine test was accurate. The …

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells For Parkinson's Disease: A Randomized Trial., Mya C Schiess, Jessika Suescun, Juan D Martinez-Lemus, Charles Green, Tia S Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B Satani, Jerome G Saltarrelli, Christopher Adams, Marie-Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M Rodarte, Sean I Savitz, Timothy M Ellmore

Faculty, Staff and Student Publications

Background: Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo-hMSCs) may reduce neuroinflammation and improve motor symptoms.

Objectives: To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo-hMSCs in improving motor symptoms in patients with PD (PwP).

Methods: In this phase 2, randomized, placebo-controlled trial (November 2020-July 2023), mild-to-moderate PwP received either three allo-hMSC infusions, one placebo followed by two allo-hMSC infusions, or three placebo infusions at 18-week intervals. Follow-up lasted 88 weeks. The primary outcome was a >70% posterior probability (PP) of a difference in the proportion of participants …

Prospective Trial Of Cerebrospinal Fluid Filtration After Aneurysmal Subarachnoid Hemorrhage Via Lumbar Catheter Extension (Pillar-Xt), Spiros L Blackburn, Marc A Babi, Andrew W Grande, Omar A Choudhri, Erik F Hauck, Christopher P Kellner, Michael C Giordano, Shivanand P Lad, Aaron R Mccabe

Faculty, Staff and Student Publications

Background: There is a growing consensus that blood in the cerebrospinal fluid (CSF) is deleterious to outcomes in patients with aneurysmal subarachnoid hemorrhage. The extracorporeal filtration of subarachnoid hemorrhage via spinal catheter extension study evaluated the safety, tolerability, and filtration curve of blood and its lysis products from hemorrhagic CSF using the Neurapheresis CSF Management System.

Methods: After aneurysm repair, a dual-lumen intrathecal catheter was inserted into the study participant's spinal canal. CSF was extracorporeally filtered for up to 72 h, removing blood products from the lumbar cistern, and reintroducing filtered CSF to the thoracic subarachnoid space. Neurological examinations were …

Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy B Grossman, Zhen Zhao

Faculty, Staff and Student Publications

Background: Preeclampsia (PE) is a complex disorder with significant maternal and fetal risks. The soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio shows promise as a diagnostic tool, but its adoption in the U.S. remains limited due to the lack of accessible testing platforms, U.S.-based studies, and evidence-based implementation guidelines.

Patients/materials and methods: We conducted a cohort study to evaluate the sFlt-1/PlGF ratio for predicting PE within two weeks among pregnant individuals ≥18 years, ≥20 weeks gestation. Serum samples were obtained from routine prenatal visits or triage evaluations. sFlt-1/PlGF ratios were measured using Roche Elecsys assays, and …

Does Reducing Videofluoroscopy Frame Rate Affect Dige/St Grades In Modified Barium Swallow Studies?, Shitong Mao, Carla L Warneke, Sheila N Buoy, Ariana J Sahli, Brinda Rao Korivi, Carly E A Barbon, Kristy K Brock, Katherine A Hutcheson

Faculty, Staff and Student Publications

Understanding the effects of reduced frame rates on the reliability of Modified Barium Swallow (MBS) ratings for swallowing safety and efficiency is essential for clinical practice. While previous research has examined frame rate (simulated pulse rates) implications concerning penetration, aspiration, and residue ratings, the impact on summary grading systems like the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) remains unclear. This study analyzed a total of 315 full MBS videos collected from 278 patients, and 76.25% of patients were diagnosed with head and neck cancer (mean age 62.51 years, SD 8.53; 12.23% female). We performed pairwise comparisons of DIGEST grades …

Tumor Intrinsic Mettl5 Modulates Atf4 Translation To Prevent T Cell-Induced Ferroptosis In Ovarian Cancer, Jiakai Hou, Cheng-Wei Ju, Nicholas A Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E Gerges, Mason D Flores, Han Li, Li-Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J Mcgrail, Nidhi Sahni, Chuan He, Amir A Jazaeri, Weiyi Peng

Faculty, Staff and Student Publications

Poor clinical responses to immune checkpoint blockade (ICB) observed in ovarian cancer (OC) highlight an unmet need to understand the mechanisms driving immune evasion in this disease. To address this, an integrative analysis is conducted by combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining, and METTL5 is identified as a crucial OC‐intrinsic factor that promotes immune resistance. Immunologically “cold” OC tumors and poor responders to ICB exhibit elevated METTL5 expression. Mechanistically, knocking out (KO) METTL5 in OC disrupts ATF4 translation by altering 18S rRNA m6A levels, leading to the downregulation of SLC7A11 and SLC3A2 …