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Articles 118531 - 118560 of 5156679
Full-Text Articles in Entire DC Network
Benchmarking Empirical Severity For The Yale-Brown Obsessive Compulsive Scale-Second Edition, Caitlin M Pinciotti, Juliana Avery, Chencheng Zhang, Josselyn S Muñoz, Dayan Berrones, Vanessa Zavala Cruz, Andrew D Wiese, Jacey L Anderberg, Renee M Frederick, Tomás Miño, Nuria Lanzagorta, Juan Camilo Restrepo, Marcos E Ochoa-Panaifo, Wayne K Goodman, James J Crowley, Eric A Storch, Matti Cervin
Benchmarking Empirical Severity For The Yale-Brown Obsessive Compulsive Scale-Second Edition, Caitlin M Pinciotti, Juliana Avery, Chencheng Zhang, Josselyn S Muñoz, Dayan Berrones, Vanessa Zavala Cruz, Andrew D Wiese, Jacey L Anderberg, Renee M Frederick, Tomás Miño, Nuria Lanzagorta, Juan Camilo Restrepo, Marcos E Ochoa-Panaifo, Wayne K Goodman, James J Crowley, Eric A Storch, Matti Cervin
Faculty, Staff and Students Publications
The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is considered the primary instrument for assessing the presence and severity of obsessive-compulsive disorder (OCD). Conceptual and empirical critiques inspired the development of an updated version of the instrument, the Yale-Brown Obsessive Compulsive Scale-Second Edition (Y-BOCS-II), with a higher ceiling of OCD severity to better differentiate between severe and the most debilitating OCD presentations, among other revisions. The Y-BOCS-II has demonstrated sound psychometric properties across diverse samples. Empirically derived severity benchmarks have been proposed for the original Y-BOCS, yielding somewhat different ranges than what has been commonly used in clinical and research settings, yet …
Corrigendum To “Clinical Characteristics And Longitudinal Associations With Obsessive-Compulsive Disorder In Youth Exposed To Trauma” [J Mood Anxiety Disord 10c (2025) 100117], Caitlin M Pinciotti, Paul J Rathouz, Andrew G Guzick, Jeffrey D Shahidullah, Emily J Bivins, David B Riddle, Ogechi Cynthia Onyeka, Eric A Storch, Wayne K Goodman, Kelli Franco, Justin F Rousseau, D Jeffrey Newport, Karen Dineen Wagner, Charles B Nemeroff
Corrigendum To “Clinical Characteristics And Longitudinal Associations With Obsessive-Compulsive Disorder In Youth Exposed To Trauma” [J Mood Anxiety Disord 10c (2025) 100117], Caitlin M Pinciotti, Paul J Rathouz, Andrew G Guzick, Jeffrey D Shahidullah, Emily J Bivins, David B Riddle, Ogechi Cynthia Onyeka, Eric A Storch, Wayne K Goodman, Kelli Franco, Justin F Rousseau, D Jeffrey Newport, Karen Dineen Wagner, Charles B Nemeroff
Faculty, Staff and Students Publications
This corrects the article "Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma" in volume 10, 100117.
Emergency Lending By The Federal Reserve, Kathryn Judge, Richard Clarida
Emergency Lending By The Federal Reserve, Kathryn Judge, Richard Clarida
Faculty Scholarship
The Federal Reserve established an array of innovative emergency lending facilities during the Great Financial Crisis and expanded the scope of its emergency lending yet further in response to the Covid-19 pandemic. This Article provides a retrospective of how the Federal Reserve used its emergency lending authority across these two episodes, identifying patterns and revealing some differences. It sheds light on the conditions that enabled the Federal Reserve to establish the facilities that it did, including the roles played by Congress and Treasury in providing the equity funding that made certain facilities possible. It shows how in each episode, the …
The Autonomy Default Paradigm In Contract Law, Hanoch Dagan, Michael A. Heller
The Autonomy Default Paradigm In Contract Law, Hanoch Dagan, Michael A. Heller
Faculty Scholarship
You can scribble an agreement on a napkin or hire lawyers to negotiate a hundred-page contract. Either way, most of your contractual obligations will not be in your document. They will be in the background rules contract law applies absent your express agreement. Justifying these defaults is a core task of contract theory; getting them right is a core task of contract law.
This Article introduces the autonomy default paradigm, a conceptually coherent and normatively attractive account of contract law defaults. We show that defaults are justified to the extent they enhance our autonomy, understood as self-determination. They vindicate our …
Feasibility Of Expiratory Muscle Strength Training In Individuals With Progressive Supranuclear Palsy, Katya Villarreal-Cavazos, James C Borders, James A Curtis, Jordanna S Sevitz, Nora Vanegas-Arroyave, Michelle S Troche
Feasibility Of Expiratory Muscle Strength Training In Individuals With Progressive Supranuclear Palsy, Katya Villarreal-Cavazos, James C Borders, James A Curtis, Jordanna S Sevitz, Nora Vanegas-Arroyave, Michelle S Troche
Faculty, Staff and Students Publications
Introduction: Dysphagia is common among individuals with Progressive Supranuclear Palsy (PSP). Expiratory muscle strength training (EMST) is a treatment used to increase expiratory muscle force production for airway protection deficits. To our knowledge, no studies have tested EMST in this population. The objective of this study was to determine the feasibility of EMST in individuals with PSP.
Methods: Twenty-nine participants completed baseline measures of maximum expiratory pressure and underwent a trial session of EMST. EMST was considered feasible if participants were able to complete at least 10 repetitions at 30% of their maximum expiratory pressure. Qualitative analyses were also completed …
A Multimodal Non-Invasive Approach For Intracranial Pressure Assessment: A Single-Center Study, Dana Klavansky, Helaina Lehrer, Aris Desai, Gabriela Keeton, Neha Dangayach, Alexandra Reynolds, Spyridoula Tsetsou
A Multimodal Non-Invasive Approach For Intracranial Pressure Assessment: A Single-Center Study, Dana Klavansky, Helaina Lehrer, Aris Desai, Gabriela Keeton, Neha Dangayach, Alexandra Reynolds, Spyridoula Tsetsou
Faculty, Staff and Students Publications
Background: Intracranial pressure (ICP) monitoring is an integral part of acute brain injury management. While invasive ICP monitoring is the gold standard, there are several medical conditions that preclude its placement. The aim of the present study is to validate a multimodal approach for increasing ICP detection.
Material and methods: In this retrospective study, patients with acute brain injury who had an external ventricular drain (EVD) placement were included. We measured bilateral optic nerve sheath diameter (ONSD) and assessed for optic nerve disk elevation (ONDE) by using ocular ultrasound, bilateral middle cerebral artery pulsatility index (PI) by using transcranial Doppler, …
Exploration Of Zileuton Protective Mechanisms Against Vancomycin-Associated Nephrotoxicity, Cole S Hudson, James E Smith, Rongjin Sun, Linh T Vuong, Luan D Truong, David Sheikh-Hamad, Masayuki Nigo, Ming Hu, Vincent H Tam
Exploration Of Zileuton Protective Mechanisms Against Vancomycin-Associated Nephrotoxicity, Cole S Hudson, James E Smith, Rongjin Sun, Linh T Vuong, Luan D Truong, David Sheikh-Hamad, Masayuki Nigo, Ming Hu, Vincent H Tam
Faculty, Staff and Students Publications
Vancomycin is one of the most commonly used parenteral antibiotics for treating drug-resistant bacterial infections, however, it is hindered by nephrotoxicity. We previously demonstrated that zileuton could delay the onset of vancomycin-associated nephrotoxicity in rats. Here, we sought to understand the mechanism(s) of zileuton renal protection. Sprague-Dawley rats were administered vancomycin (200 mg/kg) and zileuton (1 and 4 mg/kg) daily for 10 days. After 3 days, kidneys were collected from select animals for histopathological analysis of renal injury. Single-dose vancomycin serum pharmacokinetics and renal tissue spatial distribution with adjuvant zileuton were evaluated. In vitro, proximal tubular cells were exposed …
Reproductive Impact Of Immune Checkpoint Inhibitor Therapy In Women With Melanoma, Quinn Rhodes, Terri L Woodard, Laura Detti, Michael Roth, Susan Shott, Jennifer Mcquade, Laurie J Mckenzie
Reproductive Impact Of Immune Checkpoint Inhibitor Therapy In Women With Melanoma, Quinn Rhodes, Terri L Woodard, Laura Detti, Michael Roth, Susan Shott, Jennifer Mcquade, Laurie J Mckenzie
Faculty, Staff and Students Publications
Objective: To study the reproductive impact of immune checkpoint inhibitor (ICI) therapy in cis-females with melanoma.
Design: Retrospective cross-sectional study that examined the reproductive outcomes of female patients exposed to systemic ICI therapy.
Subjects: Cis-female patients, aged 18-40 years, with advanced-stage melanoma and no prior sterilization procedures or exposure to other systemic antineoplastic therapies who underwent treatment with systemic ICI therapy.
Exposure: Systemic ICI treatment as first-line, only-line therapy for advanced-stage melanoma.
Main outcome measures: Menstrual cycle data, contraceptive use, antimüllerian hormone and follicle-stimulating hormone values, and reproductive outcomes (occurrence of pregnancy) during and after ICI exposure.
Results: There were …
Group Concept Mapping To Develop A Salon-Based Hpv Self-Collection Intervention, Kelly N B Palmer, Namoonga M Mantina, Adebola Adegboyega, Itunu O Sokale, Kathleen Pryor, Azaria Suero-Davis, Trevon Brooks, Jennifer Hatcher
Group Concept Mapping To Develop A Salon-Based Hpv Self-Collection Intervention, Kelly N B Palmer, Namoonga M Mantina, Adebola Adegboyega, Itunu O Sokale, Kathleen Pryor, Azaria Suero-Davis, Trevon Brooks, Jennifer Hatcher
Faculty, Staff and Students Publications
Background: Black women in the US face higher cervical cancer mortality rates due to delayed diagnoses linked to lower screening rates. Contributing factors include provider bias, costs, and limited access, particularly affecting women aged 40-64. While innovative approaches like clinical and home-based HPV self-collection exist, equitable dissemination remains challenging. Distributing HPV self-collection kits in unconventional sites like hair salons may offer a solution. Using concept mapping, we gathered community insights to design a salon-based cervical cancer screening intervention.
Methods: We employed groupwisdom™ and REDCap platforms for community-based participatory intervention development. Participants included members of the Black Community Advisory Council of …
Rbm8a Deficiency Causes Hematopoietic Defects By Modulating Wnt/Pcp Signaling, Agnese Kocere, Elena Chiavacci, Charlotte Soneson, Seth T Jacobson, Emma N Harrison, Kevin Manuel Méndez-Acevedo, Jacalyn S Macgowan, Harrison H Wells, Max S Hiltabidle, Azhwar Raghunath, Jordan A Shavit, Daniela Panáková, Margot L K Williams, Mark D Robinson, Christian Mosimann, Alexa Burger
Rbm8a Deficiency Causes Hematopoietic Defects By Modulating Wnt/Pcp Signaling, Agnese Kocere, Elena Chiavacci, Charlotte Soneson, Seth T Jacobson, Emma N Harrison, Kevin Manuel Méndez-Acevedo, Jacalyn S Macgowan, Harrison H Wells, Max S Hiltabidle, Azhwar Raghunath, Jordan A Shavit, Daniela Panáková, Margot L K Williams, Mark D Robinson, Christian Mosimann, Alexa Burger
Faculty, Staff and Students Publications
Thrombocytopenia-Absent Radius (TAR) syndrome is a rare congenital condition with reduced platelets, forelimb anomalies, and variable heart and kidney defects. TAR syndrome is caused by mutations in RBM8A/Y14, a component of the exon junction complex. How perturbing a general mRNA-processing factor causes the selective TAR Syndrome phenotypes remains unknown. Here, we connect zebrafish rbm8a perturbation to early hematopoietic defects via attenuated non-canonical Wnt/Planar Cell Polarity (PCP) signaling. In hypomorphic rbm8a zebrafish, we observe a reduction of cd41-positive thrombocytes. rbm8a-mutant zebrafish accumulate mRNAs with retained introns, including non-canonical Wnt/PCP pathway components resulting in convergent extension defects. We found that reduced rbm8a …
A Roadmap To Scale Up Person-Centred Care In The Hiv Response: Recommendations From A Global Consensus-Building Process, Lina Golob, Elvin H Geng, Et Al.
A Roadmap To Scale Up Person-Centred Care In The Hiv Response: Recommendations From A Global Consensus-Building Process, Lina Golob, Elvin H Geng, Et Al.
2020-Current year OA Pubs
INTRODUCTION: World Health Organization global normative guidance recommends person-centred care (PCC) approaches to reduce HIV-related mortality and morbidity and to improve health-related quality of life (HrQoL). However, consensus on the priority PCC elements and guidance on how different stakeholders can realize PCC principles at the health systems, service delivery and individual client-healthcare worker (HCW) levels are lacking. We conducted a global consensus-building process to define core PCC elements and develop recommendations for implementation at scale.
METHODS: We used a multi-phase process to build consensus and prioritize recommendations, consisting of a literature review, five stakeholder consultations (34-43 participants each) between July …
Brain Functional Connectivity, But Not Neuroanatomy, Captures The Interrelationship Between Sex And Gender In Preadolescents, Athanasia Metoki, Roselyne J Chauvin, Evan M Gordon, Timothy O Laumann, Benjamin P Kay, Babatunde Adeyemo, Samuel R Krimmel, Scott Marek, Anxu Wang, Andrew N Van, Noah J Baden, Vahdeta Suljic, Kristen M Scheidter, Julia Monk, Forrest I Whiting, Nadeshka J Ramirez-Perez, Deanna M Barch, Aristeidis Sotiras, Nico U F Dosenbach
Brain Functional Connectivity, But Not Neuroanatomy, Captures The Interrelationship Between Sex And Gender In Preadolescents, Athanasia Metoki, Roselyne J Chauvin, Evan M Gordon, Timothy O Laumann, Benjamin P Kay, Babatunde Adeyemo, Samuel R Krimmel, Scott Marek, Anxu Wang, Andrew N Van, Noah J Baden, Vahdeta Suljic, Kristen M Scheidter, Julia Monk, Forrest I Whiting, Nadeshka J Ramirez-Perez, Deanna M Barch, Aristeidis Sotiras, Nico U F Dosenbach
2020-Current year OA Pubs
Understanding sex differences in the adolescent brain is crucial, as they relate to sex-specific neurological and psychiatric conditions. Predicting sex from adolescent brain data may reveal how these differences influence neurodevelopment. Recently, attention has shifted toward socially-identified gender (distinct from sex assigned at birth) recognizing its explanatory power. This study evaluates whether resting-state functional connectivity (rsFC), cortical thickness, or cortical volume better predicts sex and sex/gender alignment (congruence between sex and gender) in preadolescents. Using Adolescent Brain Cognitive Development (ABCD) Study data and machine learning, rsFC predicted sex more accurately (85 %) than cortical thickness (76 %) and cortical volume …
Current Practices And Trends In Surgical Decision-Making For Children With Lennox-Gastaut Syndrome: A Cross-Sectional Survey By The Pediatric Epilepsy Research Consortium, Michelle Y Chiu, Renée A Shellhaas, Et Al.
Current Practices And Trends In Surgical Decision-Making For Children With Lennox-Gastaut Syndrome: A Cross-Sectional Survey By The Pediatric Epilepsy Research Consortium, Michelle Y Chiu, Renée A Shellhaas, Et Al.
2020-Current year OA Pubs
OBJECTIVE: The objective of this study is to characterize contemporary surgical management practices and factors influencing surgical decision-making in the management of Lennox-Gastaut Syndrome (LGS) across pediatric epilepsy centers in the United States.
METHODS: A 45-item cross-sectional survey was developed and distributed to Pediatric Epilepsy Research Consortium centers. Domains included institutional demographics, surgical evaluation timing and goals, presurgical workup, procedural utilization and outcomes, and barriers to surgery. Descriptive statistics and thematic analysis were performed.
RESULTS: Thirty-two pediatric epilepsy centers participated (38% response), the majority comprising pediatric epileptologists at Level 4 National Association of Epilepsy Centers. Most centers (66%) considered surgery …
Renal Replacement Therapy In Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review And Meta-Analysis, Hassan Kawtharany, Jessica N Williams, Et Al.
Renal Replacement Therapy In Lupus Nephritis-Related End-Stage Kidney Disease: A Systematic Review And Meta-Analysis, Hassan Kawtharany, Jessica N Williams, Et Al.
2020-Current year OA Pubs
OBJECTIVE: To assess the impact of renal replacement therapy in people with lupus nephritis (LN)-associated end-stage kidney disease (ESKD) and support the development of the 2024 American College of Rheumatology LN treatment guidelines.
METHODS: We conducted a systematic literature review and meta-analysis to address three Population, Intervention, Comparison, and Outcome (PICO) questions related to renal replacement therapy for ESKD due to LN, including comparisons of kidney transplant versus dialysis, hemodialysis versus peritoneal dialysis, and preemptive kidney transplant versus no preemptive kidney transplant. Outcomes of interest included mortality, cardiovascular (CV) events, infections, lupus flares, disease-related damage, graft failure, and quality of …
Muc15 Ectodomain Architecture Regulates Integrin Clustering To Control Cancer Metastasis, Simei Zhang, Guy M Genin, Et Al.
Muc15 Ectodomain Architecture Regulates Integrin Clustering To Control Cancer Metastasis, Simei Zhang, Guy M Genin, Et Al.
2020-Current year OA Pubs
Cancer metastasis is governed by physical cues at the cell-matrix interface, with matrix stiffness, ligand density, and topography established as key determinants. Here, a fourth critical factor in cancer metastasis, the architecture of the cell-surface glycocalyx is identified. Using MUC15 as a representative small glycoprotein, mathematical modeling and domain truncation experiments are combined to show that glycoprotein size distribution governs integrin adhesion states and metastatic outcomes. MUC15 localizes to focal adhesions and interact with integrins, while larger glycoproteins such as MUC1 are sterically excluded. These physical effects, rather than intracellular signaling, dictate adhesion state transitions: removing MUC15's ectodomain eliminated its …
Oral Tranexamic Acid For Lichen Planus Pigmentosus Inversus: A Case Report Of Therapeutic Success, Tory Starzyk, Mehraeil Zaki, Brittani Remé, Summer Moon
Oral Tranexamic Acid For Lichen Planus Pigmentosus Inversus: A Case Report Of Therapeutic Success, Tory Starzyk, Mehraeil Zaki, Brittani Remé, Summer Moon
Student Publications
Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus typically found in middle-aged patients of color with dark brown or gray patches on sun-exposed areas such as the face, trunk, and upper extremities.1 A rarer variant is lichen planus pigmentosus inversus (LPPI), which, in contrast to LPP, more commonly affects Caucasians and has a predilection for intertriginous regions like the axillae, groin, abdominal folds, and antecubital and popliteal areas.2 Few case reports describe effective treatments for LPP, and even fewer on LPPI. Topical tretinoin and tacrolimus 0.1% ointment are the most commonly used treatments; however, responses vary.3 To …
Assessing Patient Experiences And Priorities In Traumatic Brain Injury Health Care, Temitayo R. Okusanya, Madeline D. Furie, Sergey Tarima, Courtney O. Barry, Terri Deroon-Cassini, Yuka Kobayashi, Michael A. Mccrea, Kathleen S. Williams, Staci A. Young, Lindsay D. Nelson
Assessing Patient Experiences And Priorities In Traumatic Brain Injury Health Care, Temitayo R. Okusanya, Madeline D. Furie, Sergey Tarima, Courtney O. Barry, Terri Deroon-Cassini, Yuka Kobayashi, Michael A. Mccrea, Kathleen S. Williams, Staci A. Young, Lindsay D. Nelson
Biostatistics Faculty Publications
Improving patient experiences and outcomes of traumatic brain injury (TBI) will require understanding patient perspectives of current care systems. Experts have called for building more integrated, patient-centered systems of care to better support patients through stages of TBI recovery. Informed by an earlier qualitative study, we conducted a survey to quantify patient perspectives on discharge and post-discharge experiences across seven hospitals in a single southeastern Wisconsin health system. Eligible participants were English or Spanish speakers and received TBI care between February 2023 and June 2024 at one level I trauma center emergency department (ED) and inpatient unit, two level III …
A Bioinformatic Survey Of Rna Isoform Diversity And Expression Across 9 Gtex Tissues Using Long-Read Sequencing Data, Madeline L. Page, Bernardo Aguzzoli Heberle, J. Anthony Brandon, Mark E. Wadsworth, Lacey A. Gordon, Kayla A. Nations, David W. Fardo, Mark T.W. Ebbert
A Bioinformatic Survey Of Rna Isoform Diversity And Expression Across 9 Gtex Tissues Using Long-Read Sequencing Data, Madeline L. Page, Bernardo Aguzzoli Heberle, J. Anthony Brandon, Mark E. Wadsworth, Lacey A. Gordon, Kayla A. Nations, David W. Fardo, Mark T.W. Ebbert
Biostatistics Faculty Publications
Background: Even though alternative RNA splicing was discovered nearly 50 years ago (1977), we still understand very little about most isoforms arising from a single gene, including in which tissues they are expressed and if their functions differ. Human gene annotations suggest remarkable transcriptional complexity, with approximately 252,798 distinct RNA isoform annotations from 62,710 gene bodies (Ensembl v109; 2023), emphasizing the need to understand their biological effects. For example, 256 gene bodies have ≥ 50 annotated isoforms, and 30 have ≥ 100, where one protein-coding gene (MAPK10) even has 192 distinct RNA isoform annotations. Whether such isoform diversity results from …
Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M.P. Shade, Daniel Dicorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, Alexa Beiser, Joshua C. Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Charles S. Decarli, Harsha Doddapaneni, Josée Dupuis, David W. Fardo, Jose C. Florez, Stacey Gabriel, Richard A. Gibbs, David C. Glahn, Namrata Gupta, Hector M. González
Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M.P. Shade, Daniel Dicorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, Alexa Beiser, Joshua C. Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Charles S. Decarli, Harsha Doddapaneni, Josée Dupuis, David W. Fardo, Jose C. Florez, Stacey Gabriel, Richard A. Gibbs, David C. Glahn, Namrata Gupta, Hector M. González
Biostatistics Faculty Publications
To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associations of these genetic scores with neurological outcomes in >17k participants (36% men, mean age 55 yrs) from the Trans-Omics for Precision Medicine (TOPMed) program (50% Non-Hispanic White, 23% Black/African American, 21% Hispanic/Latino American, and 4% Asian American). We report significant negative associations (P < 0.002) of the cross-population (P = 1.3 × 10-5) and European (PEA = 3.0 × 10-8) fasting insulin PSs with total cranial volume, …
Do Communities Implementing The Communities That Heal Intervention Have Significantly Lower Rates Of High-Risk Opioid Prescribing And Dispensing?, Frances R. Levin, Douglas R. Oyler, Denise C. Babineau, Jennifer Villani, Redonna K. Chandler, Patricia R. Freeman, Daniel P. Alford, Naleef Fareed, Nicole Mack, Trang Q. Nguyen, Daniel M. Walker, Joella Adams, Trevor J. Baker, Donna Beers, Shoshana N. Benjamin, Jennifer Bhuiyan, Derek Blevins, James L. David, Netrali Dalvi, Lauren D'Costa, Daniel J. Feaster, La Shawn Glasgow, Dawn A. Goddard-Eckrich, Yi Han, Mallory Harris, Timothy Hunt, Charles Knott, Adrienne Matson
Do Communities Implementing The Communities That Heal Intervention Have Significantly Lower Rates Of High-Risk Opioid Prescribing And Dispensing?, Frances R. Levin, Douglas R. Oyler, Denise C. Babineau, Jennifer Villani, Redonna K. Chandler, Patricia R. Freeman, Daniel P. Alford, Naleef Fareed, Nicole Mack, Trang Q. Nguyen, Daniel M. Walker, Joella Adams, Trevor J. Baker, Donna Beers, Shoshana N. Benjamin, Jennifer Bhuiyan, Derek Blevins, James L. David, Netrali Dalvi, Lauren D'Costa, Daniel J. Feaster, La Shawn Glasgow, Dawn A. Goddard-Eckrich, Yi Han, Mallory Harris, Timothy Hunt, Charles Knott, Adrienne Matson
Biostatistics Faculty Publications
Introduction: Prescription opioids can contribute to risk for opioid use disorder and overdoses. Improving prescription opioid safety is a critical component in reducing opioid risks. This report aims to determine whether communities randomized to the Communities That HEAL (CTH) intervention have significantly different rates of prescription opioid safety measures. Study Design: A multisite, 2-arm, community-level, cluster randomized, unblinded, wait-list controlled comparison trial designed to assess the effectiveness of the CTH intervention in reducing opioid-related overdose deaths among community residents 18 years of age or older (adults). Setting/Participants: Sixty-seven (67) communities in Kentucky, Massachusetts, New York, and Ohio. “Participants” were communities …
Drug Overdose Deaths In Kentucky, 2019–2024, Aaron P. Smith, Juan Lang, Carmen Canedo, Patricia R. Freeman, Lindsey R. Hammerslag, Daniel R. Harris, Amber Kizewski, Peter Rock, Nima M. Seyedtalebi, Philip M. Westgate, Jeffery Talbert, Sharon L. Walsh, Svetla Slavova
Drug Overdose Deaths In Kentucky, 2019–2024, Aaron P. Smith, Juan Lang, Carmen Canedo, Patricia R. Freeman, Lindsey R. Hammerslag, Daniel R. Harris, Amber Kizewski, Peter Rock, Nima M. Seyedtalebi, Philip M. Westgate, Jeffery Talbert, Sharon L. Walsh, Svetla Slavova
Biostatistics Faculty Publications
Background: Kentucky has historically experienced a high burden of drug overdose deaths. During the first years of the COVID-19 pandemic, the state saw a 45% increase in overdose deaths in 2020, followed by an additional 15% increase in 2021. However, drug overdose deaths declined in 2023 and 2024. This study used electronic death certificate records from the Kentucky Office of Vital Statistics (2019–2024) to evaluate whether Kentucky’s 2024 drug overdose death rates have declined to pre-pandemic levels and if declines were observed across all demographic groups. The results from Poisson regressions are reported as rate ratios (RRs) and their 95% …
Proteomic And Demographic Comparisons Of Recurrent Ischemic Stroke Patients, Nicholas Meredith, Jordan Harp, Christopher J. Mclouth, Jacqueline A. Frank, Will Cranford, Mais N. Al-Kawaz, Shivani Pahwa, Amanda L. Trout, Ann M. Stowe, David L. Dornbos, Justin F. Fraser, Keith R. Pennypacker
Proteomic And Demographic Comparisons Of Recurrent Ischemic Stroke Patients, Nicholas Meredith, Jordan Harp, Christopher J. Mclouth, Jacqueline A. Frank, Will Cranford, Mais N. Al-Kawaz, Shivani Pahwa, Amanda L. Trout, Ann M. Stowe, David L. Dornbos, Justin F. Fraser, Keith R. Pennypacker
Biostatistics Faculty Publications
Rates of recurrent strokes have remained relatively unchanged over the past couple decades, highlighting a need for advancements in secondary prevention of stroke recurrence. This study utilizes the Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) tissue bank to identify proteomic and demographic differences in recurrent ischemic stroke patients. Blood samples were collected during mechanical thrombectomy of large-vessel occlusion ischemic strokes. Plasma levels for 184 inflammatory and cardiometabolic proteins were measured in systemic blood and intracranial blood from the infarction area. Differences between recurrent and first-stroke patients were analyzed using Fisher’s Exact Test for categorical variables and Student’s independent samples …
Quantifying Nuanced Differences In Hand Dexterity Between The Dominant And Nondominant Hands Of Healthy, Right-Handed, Young Adults, Brian J. Conway, Léon Taquet, Timothy F. Boerger, Kaitlin Goetschel, Kate B. Krucoff, Sergey Tarima, Brian D. Schmit, Max O. Krucoff
Quantifying Nuanced Differences In Hand Dexterity Between The Dominant And Nondominant Hands Of Healthy, Right-Handed, Young Adults, Brian J. Conway, Léon Taquet, Timothy F. Boerger, Kaitlin Goetschel, Kate B. Krucoff, Sergey Tarima, Brian D. Schmit, Max O. Krucoff
Biostatistics Faculty Publications
When individuals present with hand injuries, clinicians often use the contralateral hand as an internal control. However, subtle differences in baseline dexterous abilities between the dominant and nondominant hands are poorly understood. To address this gap, here we quantified such differences, measured as independence (individuation) and smoothness of finger movements. A cohort of 47 right-hand-dominant healthy adults (22 males and 25 females) moved each finger independently 10 times, while joint angle data were tracked with a dataglove (CyberGlove III, CyberGlove Systems, San Jose, CA). Each finger’s performance was compared with its counterpart on the opposite hand using Wilcoxon-signed rank tests. …
Genome Annotations Matter, Madeline L. Page, Mark E. Wadsworth, Bernardo Aguzzoli Heberle, David W. Fardo, Mark T.W. Ebbert
Genome Annotations Matter, Madeline L. Page, Mark E. Wadsworth, Bernardo Aguzzoli Heberle, David W. Fardo, Mark T.W. Ebbert
Biostatistics Faculty Publications
Background: An accurate genome annotation is essential in many contexts, including RNA sequencing studies. Annotations include known genes and isoforms, detailing their location (chromosome, start, and end) and coding sequence, among other important metadata. Results: We characterized changes in human Ensembl annotations from 2014 to 2023 and the important gains in our biological understanding in recent years. While generally gene and isoform annotations increased (2014: 58,812 genes ; 2023: 62,710), some years dropped (e.g., 2016). A similar pattern exists for the gene and isoform biotypes; both 2015 (19,825) and 2017 (19,828) have fewer genes annotated as protein-coding than 2014 (19,953) …
Using An Intersectional Framework To Explore Cannabis And Tobacco Co-Use Patterns, Bethany Shorey Fennell, Cherell Cottrell-Daniels, Kory Heier, Kristen Mcquerry
Using An Intersectional Framework To Explore Cannabis And Tobacco Co-Use Patterns, Bethany Shorey Fennell, Cherell Cottrell-Daniels, Kory Heier, Kristen Mcquerry
Biostatistics Faculty Publications
Cannabis and tobacco co-use is an emerging public health concern linked to increased dependence and reduced cessation success for both substances. However, little is known about how co-use patterns vary by product type, motivation, and demographic characteristics. This protocol outlines a cross-sectional study designed to characterize the frequency, type, and context of cannabis and tobacco co-use among U.S. adult tobacco users using an intersectional framework. A national sample of adults who used tobacco in the past 30 days (N = 3777) were recruited via CloudResearch Prime Panels. Participants completed detailed measures of tobacco and cannabis use, co-use behaviors, motivations, expectancies, …
Radon And Tobacco Risk Counseling During Lung Cancer Screening Shared Decision-Making, Stacy R. Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, Amanda Thaxton Wiggins, Mary Kay Rayens, Ellen J. Hahn
Radon And Tobacco Risk Counseling During Lung Cancer Screening Shared Decision-Making, Stacy R. Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, Amanda Thaxton Wiggins, Mary Kay Rayens, Ellen J. Hahn
Biostatistics Faculty Publications
Objective: Examine frequency of tobacco and radon risk counseling during lung cancer screening shared decision making among qualified health care providers and the relationship between radon beliefs, tobacco and radon counseling self-efficacy, and related tobacco and radon risk counseling among providers. Methods: Cross-sectional, observational study design employing a mailed self-report survey sent to a stratified random sample of 1,000 qualified health care providers in Kentucky. Regression analyses to examine the association among sociodemographic characteristics, radon beliefs, self-efficacy, familiarity with lung cancer screening guidelines, and tobacco or radon risk reduction counseling during lung cancer screening shared decision making. Results: In all, …
The Role Of Social Media In Beauty Marketing: Insights From Kidfluencers, Brand Withdrawal, And Consumers’ Attitudes, Avery Giddings
The Role Of Social Media In Beauty Marketing: Insights From Kidfluencers, Brand Withdrawal, And Consumers’ Attitudes, Avery Giddings
Business/Business Administration
This thesis examines the evolving role of social media in beauty marketing by analyzing industry trends, ethical considerations, and consumer perceptions. The paper first outlines how social media has transformed digital marketing, enabling brands to merge advertising, community-building, and e-commerce. Two case studies highlight contrasting dynamics within this landscape: the rise of “kidfluencers,” which raises concerns about privacy and potential financial exploitation; and Lush Cosmetics’ decision to withdraw from major social media platforms, a move rooted in ethical branding but accompanied by economic challenges. To further investigate consumer attitudes, a survey of 150 U.S. participants assessed social media usage patterns, …
Robert Kuhn Mautz [Inducted 1978], American Accounting Association
Robert Kuhn Mautz [Inducted 1978], American Accounting Association
Accounting Hall of Fame Brochures
No abstract provided.
Piezoelectric Energy Harvesting From Roadways: Challenges, Advances, And Future Directions, Heba Gaber, Mohamed Abdelraheem
Piezoelectric Energy Harvesting From Roadways: Challenges, Advances, And Future Directions, Heba Gaber, Mohamed Abdelraheem
Faculty Publications
As the global demand for renewable energy intensifies, piezoelectric energy harvesting from roadways has emerged as a promising avenue for sustainable power generation. This systematic literature review analyzes 61 peer-reviewed studies to assess the feasibility, performance, and potential of integrating piezoelectric systems into roadway infrastructure. While technology faces challenges, such as high installation costs, limited energy output, and a scarcity of thorough economic evaluations, findings suggest it holds considerable promise as a supplementary renewable energy source. The review analyzes the operational characteristics and efficiencies of various piezoelectric transducers, identifies key factors influencing system performance, and evaluates recent technological advances. It …
Where, How, And How Much? A Multicenter Cohort Study Of The Relationship Across Lupus Decision-Aid Modality, Place Of Administration, Interruption And Viewing Completeness, And Patient-Reported Outcomes, Jasvinder A Singh, Mark Beasley, Larry R Hearld
Where, How, And How Much? A Multicenter Cohort Study Of The Relationship Across Lupus Decision-Aid Modality, Place Of Administration, Interruption And Viewing Completeness, And Patient-Reported Outcomes, Jasvinder A Singh, Mark Beasley, Larry R Hearld
Faculty, Staff and Students Publications
Objective: We assessed whether shared decision-making (SDM) and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE) differs by PtDA setting, modality, and the viewing experience.
Methods: Patients with SLE were invited to view a self-administered computerized SLE PtDA during regular clinic visits at 15 rheumatology clinics in an implementation trial. Patients completed a survey that included SDM measures including the decision conflict scale (DCS), Preparation for Decision Making (PDM) scale, and CollaboRATE scale, and we measured perceived patient acceptability, feasibility, and satisfaction. Patients viewed the SLE PtDA in …