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Operation Paperclip And The Use Of National Security: Si Vis Pacem, Para Bellum, Kirsten Hawkins Dec 2025

Operation Paperclip And The Use Of National Security: Si Vis Pacem, Para Bellum, Kirsten Hawkins

War, Diplomacy, and Society (MA) Theses

National security is a term that many are familiar with in the twenty-first century. In the United States it is commonly believed that its widespread use began after the attacks on the World Trade Center in New York on September 11, 2001. However, this work examines how the United States government has used the term and changed its definition in its application during Operation Paperclip. Operation Paperclip was a Second World War operation created to secure the scientific and technical research of German scientists at the end of the war in 1945.

This thesis examines Operation Paperclip and its expansion …


Community Approaches To Digitally Documenting And Sharing Conjunto Music In The South Texas Borderlands, René Antonio Ballesteros Dec 2025

Community Approaches To Digitally Documenting And Sharing Conjunto Music In The South Texas Borderlands, René Antonio Ballesteros

Theses and Dissertations

This thesis explores the rich tradition of conjunto music within the South Texas borderlands, examining how integrating community engagement and digital humanities methodologies can effectively enhance the documentation, conservation, and presentation of this place-based expressive culture. Recognizing existing archival gaps, the research employed community-engaged programming to gather and preserve valuable cultural data. A key methodology outcome involved creating digital maps utilizing place-based data related to conjunto music sites and activities, subsequently integrating these maps into an ArcGIS Online story map for public online access. The findings demonstrate the significant potential of community collaboration and digital humanities tools in amplifying cultural …


Testing Microscopic Approaches For Cementochronology In The 21st Century Identified Skeletal Collection, Portugal, Amando Luis Montalvo Jr. Dec 2025

Testing Microscopic Approaches For Cementochronology In The 21st Century Identified Skeletal Collection, Portugal, Amando Luis Montalvo Jr.

Theses and Dissertations

Age-at-death estimation is a key component to the creation of a biological profile in forensic anthropology. Acellular extrinsic fiber cementum annulations have been shown to correlate with chronological age. Cementochronology examines this correlation through the sum of the alternating translucent bands and opaque annuli, and the age of eruption of a tooth. While several microscopy techniques have been used, there is no consensus on the most optimal. This study will assess the reliability, precision and accuracy of three microscopy techniques: Brightfield (BF), Phase Contrast (PC) and Differential Interference Contrast (DIC). PC was the most reliable (rTEM= 10.4%), the most precise …


Towards Trustworthy Federated Learning, Alina Basharat Dec 2025

Towards Trustworthy Federated Learning, Alina Basharat

Theses and Dissertations

Federated learning is a collaborative training model in which multiple clients optimize aglobal model by transmitting updates to a coordinating server while keeping raw data on-device, thereby reducing direct data exposure and enabling iterative global improvement. However, the iterative communication process is vulnerable to malicious attackers that either deliberately destroy the model or curious to infer raw data. Moreover, learning from multiple agents may result in unfair results. To enhance trustworthiness within this setting, we employ two-sided norm-based screening (TNBS) that removes both abnormally large and abnormally small updates, pair it with a q-fair objective to emphasize high-loss (disadvantaged) clients, …


When Textures Trim Drag: Micro-Structures For Adaptive Drag Reduction And Flow Authority, Miguel Angel Olvera Dec 2025

When Textures Trim Drag: Micro-Structures For Adaptive Drag Reduction And Flow Authority, Miguel Angel Olvera

Theses and Dissertations

Turbulent boundary layers are a major source of drag and performance loss. This thesis investigates Triangular Porous Texturing (TPT), apex-forward microstructures with optional bleed channels, as a passive concept for simultaneously reducing skin friction and strengthening boundary layer momentum near separation. Low-speed wind tunnel tests are conducted over tripped turbulent boundary layers on flat plates with three surfaces: a smooth baseline, a solid-crest TPT array isolating the knife-edge “slip-cut” effect, and a porous-bleed TPT array whose paired micro-channels vent a small fraction of the free stream. Time-resolved PIV provides wall-normal velocity fields; skin friction is inferred from near-wall shear, and …


Clinical Phenotypes Of Motor Neurone Disease In A Kenyan Hospital-Based Population, Effie Nailah Kamadi, Jasmit Shah, Juzar Hooker, Thomas Jenkins, Dilraj Sokhi Dec 2025

Clinical Phenotypes Of Motor Neurone Disease In A Kenyan Hospital-Based Population, Effie Nailah Kamadi, Jasmit Shah, Juzar Hooker, Thomas Jenkins, Dilraj Sokhi

Internal Medicine, East Africa

Background: Motor neurone disease (MND) presentation is globally heterogenous and data on the clinical phenotype in Sub-Saharan Africa (SSA) is scarce. We sought to address this by describing the profile of MND patients in a Kenyan hospital-based population.

Methods: The medical charts of all adult MND patients assessed in the facility between January 2010 and December 2023 were retrospectively reviewed. The biographical data and clinical features of these patients were captured from their electronic and manual health records and statistical analysis performed.

Results: In total, 160 patients had their data analyzed. The male to female ratio was 1.76:1. The median …


2025 December, Morehead State University. Office Of Communications & Marketing. Dec 2025

2025 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2025.


Aged 539 Graduate Internship Report- Mount Whitney High School, Matthew C. Medeiros Dec 2025

Aged 539 Graduate Internship Report- Mount Whitney High School, Matthew C. Medeiros

Agricultural Education: Graduate Internship Reports

This project reviews the Mount Whitney High School Agricultural Education Program. Through evaluation of our program's needs, there was a lack of chapter promotion outside of social media. A chapter website was created to highlight Classroom, FFA, and SAE opportunities available to students in our program.


Neural Rrp6 Depletion Drives Circrna Accumulation And Motor Impairment In Drosophila Melanogaster Neurons, Joseph Serio Dec 2025

Neural Rrp6 Depletion Drives Circrna Accumulation And Motor Impairment In Drosophila Melanogaster Neurons, Joseph Serio

Honors Theses

Circular RNAs (circRNAs) are a class of ubiquitous eukaryotic RNAs created by back splicing. These noncoding RNAs can modulate gene expression and are implicated in aging and neurodegenerative diseases. To limit the contribution of circRNAs to aging and pathobiology, it is essential to understand how turnover of these molecules is regulated, as it is not clear which enzymes are chiefly responsible for degrading circRNAs in neurons. This study evaluates the roles of ribonucleases potentially involved in neural circRNA turnover using the model fly Drosophila melanogaster. A mifepristone-activated GAL4/UAS GeneSwitch expressed RNAi transgenes and inactivated the ribonucleases. Flies were evaluated on …


Alexander Asboth: Hungarian Separatist And Union Civil War General, Paul T. Brueske Dec 2025

Alexander Asboth: Hungarian Separatist And Union Civil War General, Paul T. Brueske

Graduate Theses and Dissertations (2019 - present)

This thesis reveals the experiences of a Hungarian Separatist, Alexander Asboth, and how he applied those experiences in the American Civil War. It examines Asboth’s biography, his expansive view of the Union, and how he differed from many commanding officers in the Western theater. Moreover, this thesis illuminates Asboth’s military service, including his leadership of a diverse force at Barrancas, Florida, and adds to the understudied collaboration of foreign-born officers and Black soldiers in Gulf Coast Civil War history.

During the 1848 Hungarian separatist movement, Asboth served as an Army staff officer under the leader Lajos Kossuth. However, the separatists …


Application Of Graph Neural Networks On Phase Space Graphs For Cybersecurity, Parker H. Cole Dec 2025

Application Of Graph Neural Networks On Phase Space Graphs For Cybersecurity, Parker H. Cole

Graduate Theses and Dissertations (2019 - present)

Non-linear phase space analysis may be used to represent time-series data as graph data with transitions between states in the time domain. By studying these transitions, we can predict anomalies within the system. Previous research has demonstrated success in learning from phase graphs for malware and seizure detection. These solutions either require extracting global features or converting the graph into an image for convolutional neural networks (CNNs), which adds a layer of complexity and limits the size and potential expressiveness of a graph. To sidestep current limitations, this study proposed Graph Neural Networks (GNNs) for analyzing phase graphs. GNNs do …


Feedback Strategies In The Market With Uncertainties, Mustapha Nyenye Issah Dec 2025

Feedback Strategies In The Market With Uncertainties, Mustapha Nyenye Issah

Graduate Theses and Dissertations (2019 - present)

This paper explores how established firms use strategic advertising to deter new competitors in uncertain markets. Specifically, it models a situation where market demand evolves unpredictably - captured by the CKLS stochastic process, and the incumbent firm may be either strong or weak, a fact hidden from potential entrants. For a company already in the market, advertising is not just about driving immediate sales, it is a strategic tool to project an image of strength and deter potential new competitors. On the other side, a business thinking about entering that market faces a high-stakes, irreversible decision. It will typically hold …


Taxonomy Of Endophytic Fungi Associated With Vallisneria Neotropicalis, Md. Arafat Rashid Dec 2025

Taxonomy Of Endophytic Fungi Associated With Vallisneria Neotropicalis, Md. Arafat Rashid

Graduate Theses and Dissertations (2019 - present)

This study presents the first comprehensive taxonomic and ecological investigation of endophytic fungi (EF) associated with the submerged aquatic macrophyte Vallisneria neotropicalis in the southern United States. Over a 12 month period, from April 2023 to March 2024, leaf samples were collected from two distinct sites in Mobile Bay, Alabama a disturbed, brackish Causeway location and a cleaner, less impacted site at Meaher State Park. Using culture dependent methods, a total of 257 fungal endophytes were isolated from 1,200 leaf segments. All isolates belonged to the phylum Ascomycota, distributed across 3 classes, 6 orders, 10 families, and 19 taxa. The …


Human Capital, Immigration, And Growth: A State-Level Dynamic Panel Study, William R. Cooper Dec 2025

Human Capital, Immigration, And Growth: A State-Level Dynamic Panel Study, William R. Cooper

Graduate Theses and Dissertations (2019 - present)

This study examines whether who immigrates, rather than how many, matters for state economic growth in the United States. It integrates a policy-relevant proxy for skill (H-1B approvals) into an augmented Solow framework that separates immigration's quantity channel from its human capital channel and estimates dynamic effects in a balanced quarterly panel of 50 states (2010 to 2023 ). The empirical strategy estimates a two-step difference GMM Arellano-Bond model that reinforces identification using a double/debiased machine learning (DML) variant that orthogonalizes high-dimensional nuisance components via cross-fitting. This design targets the distinct roles of immigrant headcount versus skill in per capita …


Modeling Flood Risks For Small-Scale Coastal Watershed Across Shared Socioeconomic Pathway Scenarios, Sebastian Loschner Dec 2025

Modeling Flood Risks For Small-Scale Coastal Watershed Across Shared Socioeconomic Pathway Scenarios, Sebastian Loschner

Graduate Theses and Dissertations (2019 - present)

Coastal flooding, driven by the mixture of natural processes and human activities such as precipitation, waves, sea level rise, and urbanization, remains a growing concern. While recent flood-risk studies use IPCC's Shared Socioeconomic Pathways with climate projections to assess future flood exposure, smaller coastal watersheds, < 120,000 acres, remain insufficiently studied. Projected sea level rise is expected to intensify these impacts in smaller systems, potentially causing more severe flooding than reported for larger watersheds. To address this gap, this study used the SRH-2D model integrated with Aquaveo's Surface-water Modeling System to simulate flooding in the lower Fish River basin, Alabama. A coastal watershed sensitive to both riverine and tidal influences. Simulations tested different sea levels based on SSP scenarios corresponding to low, moderate, and high emissions for the years 2050 and 2100. Results indicate that the midcentury scenarios remained even in inundation extent and volume, between 9.9-10.4% compared to the 2020 baseline, the latter scenarios had a wider range in results of between 25.9-50.3% compared to the same baseline. Across scenarios, the most vulnerable and inundated areas of the smaller coastal watershed were the narrow points where upstream flow convene with downstream backwater. These findings highlight the need for futuristic location-specific flood mitigation strategies.


Improved Model For Neurodegeneration In C. Elegans, Jean-Pierre Arditi Dec 2025

Improved Model For Neurodegeneration In C. Elegans, Jean-Pierre Arditi

Graduate Theses and Dissertations (2019 - present)

During Alzheimer's disease (AD), insoluble amyloid beta (AP) peptides accumulate to form extracellular aggregates (plaques). The direct cause of neuronal dysfunction observed in AD has been broadly investigated. The amyloid hypothesis states that AP plaques are neurotoxic, but recent studies support the AP oligomer hypothesis, which states that intracellular AP (iAP) is neurotoxic. To test this hypothesis, I used CRISPR-Cas9 gene editing to generate two transgenic Caenorhabditis elegans (C. elegans) strains. I generated a strain (RSLl 11) using the rab-3 promoter to co-express GFP in neurons, which showed no gross behavioral changes but had a 50% reduced egglaying rate. RSLl …


Dual-Task Interaction Between Vestibular Function And Cognitive Processing Using The P300 Event-Related Potential, Laurel Elise Money-Nolan Dec 2025

Dual-Task Interaction Between Vestibular Function And Cognitive Processing Using The P300 Event-Related Potential, Laurel Elise Money-Nolan

Graduate Theses and Dissertations (2019 - present)

Previous research has established links between vestibular function and cognitive processing, aging and cognitive function, and aging and vestibular function. Theories of cognitive resource allocation discuss how cognitive resources, such as attention, are devoted towards and divided between tasks when multitasking. This dual-task study, utilizing a balance task and a listening/cognitive task, across the young- and middle-aged adult age range, aimed to evaluate potential relationships between vestibular function, cognition, and age, and to examine how cognitive resources might be allocated under dual-task conditions.

The dual-task protocol in this study utilized an oddball paradigm with tonal stimuli to measure the P300 …


Surgical Removal Of Implanted Microchips To Correct Mri Susceptibility Artifacts In Mice, Elizabeth Hipskind, Nicole Hernandez, Sydney Fox, Tina Manirambona, Rita Schack, Brian Gibson, Robia G Pautler Dec 2025

Surgical Removal Of Implanted Microchips To Correct Mri Susceptibility Artifacts In Mice, Elizabeth Hipskind, Nicole Hernandez, Sydney Fox, Tina Manirambona, Rita Schack, Brian Gibson, Robia G Pautler

Center on Aging Staff Publications

Purpose: Implanted microchips are becoming increasingly common in research for animal identification and have been adopted by commercial vendors for some mouse strains. However, they often contain metal components, which generate magnetic susceptibility artifacts on MR images. Despite this, some microchips are marketed as MR-compatible, even though they are likely to affect image quality.

Methods: We assessed the impact of a radiofrequency identification microchip on MR images of the mouse brain and present a method for precise surgical removal. A handheld magnet was used to locate and stabilize the microchips during removal. Mice were imaged before and after microchip removal. …


Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly Dec 2025

Association Of Area Deprivation Index With Perinatal And Covid-19 Outcomes During The Early Pandemic: A Secondary Analysis Of A Prospective Cohort Study, Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter, Indira U Mysorekar, Jeannie C Kelly

Center on Aging Staff Publications

Objective: We sought to evaluate the relationship between neighborhood-level deprivation and perinatal outcomes, particularly preterm birth, as well as COVID-19 outcomes among pregnant patients during the early pandemic.

Methods: We performed a secondary analysis of a prospective longitudinal cohort study that investigated the impact of prenatal COVID-19 exposure on perinatal outcomes. Pregnant patients were recruited 12/23/20-7/18/22 and serially assessed for COVID-19 exposure during pregnancy, with serum antibody testing, electronic medical record review, and patient report. For this secondary analysis, address at the time of delivery was used to categorize patients into low ADI (≤50th percentile Area Deprivation Index, indicating low …


Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy Grossman, Zhen Zhao Dec 2025

Short-Term Preeclampsia Prediction: Cutoff Variations For Sflt-1/Plgf In U.S. Patients With Or Without Hypertensive Disorders, Yaxin Li, Kristen Cagino, Jim Yee, Caroline Andy, Dajana Borova, Ayush Shah, Isla Racine, Tracy Grossman, Zhen Zhao

Student Papers, Posters & Projects

BACKGROUND: Preeclampsia (PE) is a complex disorder with significant maternal and fetal risks. The soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio shows promise as a diagnostic tool, but its adoption in the U.S. remains limited due to the lack of accessible testing platforms, U.S.-based studies, and evidence-based implementation guidelines.

PATIENTS/MATERIALS AND METHODS: We conducted a cohort study to evaluate the sFlt-1/PlGF ratio for predicting PE within two weeks among pregnant individuals ≥18 years, ≥20 weeks gestation. Serum samples were obtained from routine prenatal visits or triage evaluations. sFlt-1/PlGF ratios were measured using Roche Elecsys assays, and …


Enhancing Learning Path Recommendation Via Multi-Task Learning, Afsana Nasrin Dec 2025

Enhancing Learning Path Recommendation Via Multi-Task Learning, Afsana Nasrin

All Theses

Personalized learning is a student-centered educational approach that acknowledges and adapts to the unique characteristics of each learner by customizing content, pacing, and assessments to meet individual needs. Key components include learner profiles, cognitive styles, learning objectives, adjustable pacing, and enabling technologies such as intelligent learning environments, intelligent tutoring systems, and data mining.

A key strategy for implementing personalized learning is learning path recommendation, a technique that guides learners through tailored sequences of content. This approach sequentially recommends personalized learning items, such as lectures, exercises, to address each student’s specific needs. Recent advances in deep learning, particularly deep reinforcement learning, …


Characterization Of Site-Specific Q295-Conjugated Tlr7 Agonist Immune-Stimulating Antibody Conjugates, Samuel Hanul Chung Dec 2025

Characterization Of Site-Specific Q295-Conjugated Tlr7 Agonist Immune-Stimulating Antibody Conjugates, Samuel Hanul Chung

Undergraduate Honors Theses

Recent advances in immunotherapy as a viable cancer treatment modality has led to the development of immune-stimulating antibody conjugates (ISACs). ISACs are analogous to antibody-drug conjugates (ADCs), which utilize the specificity and stability of an antibody to deliver cytotoxic payloads directly to a tumor. ISACs, however, deliver immune stimulating agents instead, activating adaptive and innate immune responses to engage with tumor cells. Among the various immunostimulants currently being explored, Toll-Like Receptor (TLR) agonists have risen as promising inducers of anti-cancer immune responses. Previously, the Tumey lab has explored ISACs employing an imidazole[4,5-c]quinoline TLR7 agonist with drug-antibody ratios (DAR) of ~8. …


Hkc01 - What We Do In The Shadows: How Urban Density Facilitates Information Diffusion And Civic Engagement, Qing Zhang, Evan Plous Kresch Dec 2025

Hkc01 - What We Do In The Shadows: How Urban Density Facilitates Information Diffusion And Civic Engagement, Qing Zhang, Evan Plous Kresch

Oberlin College Kasper Economics and Business Working Paper Series

Does urban density facilitate the diffusion of information and civic engagement? This paper exploits plausibly exogenous variation generated by a unique national policy in China that requires all residential buildings to receive sufficient hours of sunshine. The policy creates higher degrees of restriction on density at higher latitudes, where longer shadows require buildings to be further apart. Using differential topic dynamics on a national petition platform to measure information diffusion, this paper shows that people respond to shifts in government attention with varying speeds across latitudes. Increases in local government reply rate to a topic raises the volume of subsequent …


Understanding Dental Hygienists’ Knowledge, Attitudes, And Practices Regarding Hpv Vaccination, Paula M Cuccaro, Jihye Choi, Kawtar Zouaidi, Efrat K Gabay, Michael Mackert, Josefine Ortiz Wolfe Dec 2025

Understanding Dental Hygienists’ Knowledge, Attitudes, And Practices Regarding Hpv Vaccination, Paula M Cuccaro, Jihye Choi, Kawtar Zouaidi, Efrat K Gabay, Michael Mackert, Josefine Ortiz Wolfe

Faculty, Staff and Student Publications

The American Dental Association and American Academy of Pediatric Dentistry encourage oral health professionals to strongly recommend human papillomavirus (HPV) vaccination to prevent HPV-associated oropharyngeal cancer. This study examined oral health professionals' knowledge, attitudes, and practices regarding HPV vaccination. We used purposive sampling to recruit participants through state and national oral health societies and social media platforms. Flyers outlining eligibility criteria were distributed, and eligible participants completed an online survey. Primary measures included participants' HPV-related knowledge, attitudes, and practices, and willingness to receive HPV-related training and recommend HPV vaccination to patients, including parents of adolescents. Only responses from dental hygienists …


Updated Prevalence Estimates Of Obesity Among Adults In The United States, 2005–2018, Ashley W. Kranjac, Dinko Kranjac Dec 2025

Updated Prevalence Estimates Of Obesity Among Adults In The United States, 2005–2018, Ashley W. Kranjac, Dinko Kranjac

Sociology Faculty Articles and Research

Introduction

Body mass index is an imperfect measure of excess adiposity but is ingrained in both research and clinical practice to define and diagnose adult obesity. The addition of waist circumference measure is recommended to fully capture obesity-related health risks at a population level. The latest reframing of obesity by the Lancet Commission relies on body mass index and waist circumference, as well as organ dysfunction and functional limitations, to differentiate between preclinical and clinical obesity.

Methods

Using data from the National Health and Nutrition Examination Survey (2005–2018), we adhere to the proposed redefinition to examine obesity trends in the …


Presumption Of Creditworthiness, Nakita Q. Cuttino Dec 2025

Presumption Of Creditworthiness, Nakita Q. Cuttino

Michigan Law Review

Creditworthiness, or the likelihood that one will repay one’s debts, is typically signaled through a three-digit number known as a credit score. Yet, over thirty-two million adult-aged consumers lack adequate consumer credit reports and therefore do not have a traditional credit score. As a result of being unscored, these consumers are generally presumed uncreditworthy and foreclosed from mainstream credit markets. Unscored consumers are often relegated to extractive, fringe credit markets that neither require nor build credit scores. More insidiously, however, a growing number of non-credit contexts, including rental housing, utility services, and employment markets, look to creditworthiness to determine eligibility …


Disability Rights On Probation And Parole, Alexis Karteron Dec 2025

Disability Rights On Probation And Parole, Alexis Karteron

Michigan Law Review

This Article addresses disability discrimination in community supervision programs, a large—but frequently overlooked—component of the criminal legal system and important contributor to America’s mass incarceration crisis. The long-standing concerns of legal scholars and advocates about disability discrimination in prisons and policing, particularly against people with mental health disabilities, apply with equal measure to probation and parole. This Article examines the experiences of people with intellectual/developmental, cognitive, and mental health disabilities to understand how disability discrimination manifests in probation and parole programs and identifies numerous policies and practices that likely run afoul of two major federal disability rights laws: the Americans …


Front Matter, Michigan Law Review Dec 2025

Front Matter, Michigan Law Review

Michigan Law Review

Front Matter for Volume 124, Issue 3 of Michigan Law Review


From Medical Exceptions To Reproductive Freedom, David S. Cohen, Greer Donley Dec 2025

From Medical Exceptions To Reproductive Freedom, David S. Cohen, Greer Donley

Michigan Law Review

Since the Supreme Court overruled Roe v. Wade in 2022, there has been a significant focus on pregnancy complications. This focus has created some risks. Highlighting medically indicated abortion stories could stigmatize the vast majority of abortion seekers who lack medical reasons for abortion and result in narrow remedies that do nothing to undermine abortion bans. This Article presents a way to convert these risks into an opportunity: to use pregnancy complications as a wedge to challenge abortion bans more generally and make abortion more accessible for everyone. We present a long-term strategy to dismantle abortion bans, using several legal …


A Molecular Mechanism Of Epithelial To Mesenchymal Transition (Emt): An Evidence Based Lesson Applying Molecular Biology Through The Lens Of Cancer, Sophie Hasson, Melissa Rowland-Goldsmith Dec 2025

A Molecular Mechanism Of Epithelial To Mesenchymal Transition (Emt): An Evidence Based Lesson Applying Molecular Biology Through The Lens Of Cancer, Sophie Hasson, Melissa Rowland-Goldsmith

Open Educational Resources

This lesson aims to strengthen students’ critical thinking and molecular biology data analysis skills as well as their understanding of concepts related to the hallmark of cancer: tissue invasion and metastasis. Students begin by learning about the invasion of cancer cells, Epithelial-Mesenchymal Transition (EMT), and an important protein involved in EMT: E-cadherin. They then apply molecular biology knowledge to analyze data from multiple papers to infer the relationship between Snail and E-cadherin in different types of cancers. Next, they continue to interpret data from many papers to determine that a repressor transcription factor is present during EMT in cancer cells …