Digital Commons Network^™

Storage-Dependent Variability In Alzheimer Disease-Related Plasma Biomarker Results Using The Fujirebio Lumipulse G1200 Platform, Ibrahim Choucair, Tiffany L. Lee, Linda J. Van Eldik, Jeffrey L. Dage, Brian T. Gold, Erin L. Abner, Gregory A. Jicha, Peter T. Nelson

Epidemiology and Environmental Health Faculty Publications

Alzheimer disease plasma biomarkers have emerged as minimally invasive, cost-effective tools for early diagnosis and disease monitoring yet their stability under common “real world” pre-analytical conditions remains incompletely characterized. We evaluated the stability of six plasma biomarkers, Aβ40, Aβ42, pTau181, pTau217, NfL, and glial fibrillary acidic protein (GFAP) using the Fujirebio Lumipulse G1200 platform. Plasma samples were initially collected from four healthy and cognitively unimpaired volunteers. Samples were stored under four conditions: room temperature (0-4h), +4°C (1-10days), −20°C (1-3weeks), and −80°C (4-8weeks). In this pilot study, Aβ40 and Aβ42 remained generally stable. In contrast, pTau181 readings exhibited marked elevations in …

Using Low-Cost Sensors And Gps To Assess Spatiotemporal Variations In Personal Exposure To Pm2.5 In The Washington State Twin Registry, Ningrui Liu, Ally Avery, Elena Austin, John S. Meschke, Nicola K. Beck, Graeme Carvlin, Yisi Liu, Anne V. Moudon, Igor Novosselov, Jeffry H. Shirai, Glen E. Duncan, Edmund Seto

Epidemiology and Environmental Health Faculty Publications

Epidemiological studies typically rely on exposure assessments based on ambient PM_2.5 concentrations at participants' home addresses. However, these approaches neglect personal exposures indoors and across different non-residential microenvironments. To address this problem, our study combined low-cost sensors and GPS to conduct two-week personal PM_2.5 monitoring in 168 adults recruited from the Washington State Twin Registry between 2018 and 2021. PM_2.5 mass concentration, size-resolved particle number concentration, temperature, humidity, and GPS coordinates were recorded at 1-min intervals, providing 5,161,737 data points. We used GPS coordinates and a processing algorithm for automatic classification of microenvironments, including seven land use …

Discreet But Accessible, Rachel M. Marschke, April M. Young, Hannah K. Knudsen, Chelsi N. Cheatom, Hannah L.F. Cooper

Epidemiology and Environmental Health Faculty Publications

Background: Rural Appalachia has been significantly affected by drug-related harms (Hepatitis C, HIV, overdose deaths) over the past two decades, but harm reduction responses still lag behind other regions. Harm reduction vending machines (HRVMs) are an effective intervention for preventing overdose and the spread of infection, though they are newer to the US and have rarely scaled out to rural areas. Here, we report on guidance from people who use drugs (PWUD) and health department staff on how to adapt HRVMs to suit local needs in rural Appalachian Kentucky. Methods: Focus groups were conducted with local health department and syringe …

Engagement And Retention In A Motivational, Discovery, And Transitional Track Based Substance Use Disorder Recovery Program, Terry Lee Bunn, Robin Thompson, Madison Ashworth, Ernest Fletcher

Epidemiology and Environmental Health Faculty Publications

Background: St. Matthew’s House® Justin’s Place® Recovery Program (JPRP) is a substance use disorder recovery housing program that employs Motivational, Discovery, and Transitional Tracks. This study examined whether resident retention, resumption of substance use, family relationship restoration, and acquisition of employment were associated with JPRP completion. Methods: Secondary quantitative data from individuals with a substance use disorder who were accepted into the JPRP program and who stayed for at least one day (n = 447) was collected from January 1, 2022-August 31, 2024. Characteristics of the JPRP and its residents were identified. Logistic regression was utilized to determine the resident …

Knowledge-Informed Deep Learning To Mitigate Bias In Joint Air Pollutant Prediction, Lianfa Li, Roxana Khalili, Frederick Lurmann, Nathan Pavlovic, Jun Wu, Yan Xu, Yisi Liu, Karl O’Sharkey, Beate Ritz, Luke Oman, Meredith Franklin, Theresa Bastain, Shohreh F. Farzan, Carrie Breton, Rima Habre

Epidemiology and Environmental Health Faculty Publications

Accurate prediction of atmospheric air pollutants is critical for public health protection and environmental management. Traditional machine learning (ML) methods achieve high spatial resolution but lack physicochemical constraints, leading to systematic biases that compromise exposure estimates for epidemiological studies. Chemical transport models incorporate atmospheric physics but require expensive parameterization and often fail to capture local-scale variability crucial for health impact assessment. This gap between data-driven accuracy and physical realism presents a major obstacle to advancing air quality science. We address this challenge through a novel physics-informed deep learning framework that integrates advection–diffusion equations and fluid dynamics constraints directly into neural …

Long-Term, Bidirectional Associations Between Depressive Symptom Severity And Opioid Use Among People With Hiv, Alexandria Macmadu, Yu Li, Fiona Bhondoekhan, Chung Chou H. Chang, Anees Bahji, Stephen Crystal, Kirsha S. Gordon, Robert D. Kerns, Rachel A. Vickers-Smith, E. Jennifer Edelman, Brandon D.L. Marshall

Epidemiology and Environmental Health Faculty Publications

Background: The bidirectional relationships between opioid use and depressive symptom severity among people living with HIV (PLHIV) are poorly understood. We hypothesized that higher opioid use frequency would be associated with greater subsequent depressive symptom severity and that greater depressive symptom severity would be associated with higher subsequent opioid use frequency. Methods: We analyzed data from the Veterans Aging Cohort Study (VACS) – survey sample, a prospective cohort including PLHIV receiving care at 8 US Veterans Health Administration sites. From 2002 to 2018, we assessed past year opioid use frequency based on self-reported heroin and/or prescription opioid use at study …

Multi-Ancestry Genome-Wide Meta-Analysis Of 56,241 Individuals Identifies Known And Novel Cross-Population And Ancestry-Specific Associations As Novel Risk Loci For Alzheimer’S Disease, Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan Ping Lee, Jacob Haut, Kara L. Hamilton-Nelson, Nicholas R. Wheeler, Yi Zhao, John J. Farrell, Michelle A. Grunin, Yuk Yee Leung, Pavel P. Kuksa, Donghe Li, Eder Lucio Da Fonseca, Jesse B. Mez, Ellen L. Palmer, Jagan Pillai, Richard M. Sherva, Yeunjoo E. Song, Xiaoling Zhang, Takeshi Ikeuchi, Taha Iqbal, Omkar Pathak

Epidemiology and Environmental Health Faculty Publications

Background : Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We construct and analyze a multi-ancestry GWAS dataset in the Alzheimer’s Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer’s disease (LOAD) susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6728 African American, 8899 Hispanic (HIS), and 3232 East Asian individuals, performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. Results: We identify 13 loci with cross-population associations including known loci at/near …

Nonfatal Injury Emergency Department Visits And Inpatient Hospitalizations Among Persons Under Age 65 With An Intellectual And Developmental Disability Or Deaf Or Hard Of Hearing Disability, Terry L. Bunn, Jacqueline Seals, Dana Quesinberry, Alaina Murphy, Julia F. Costich

Epidemiology and Environmental Health Faculty Publications

Background: Vulnerable populations at risk of injury include persons with intellectual and developmental disabilities (IDD), and persons who are deaf or hard of hearing (DHH). The purpose of this study was to describe and compare emergency department and inpatient hospitalization (ED + IP) injury rates and rate ratios by injury type among persons under age 65 with IDD or with DHH to those without IDD or DHH. Methods: This is a descriptive population-based retrospective cross-sectional study of injuries among patients under the age of 65 with an IDD disability or a DHH disability using Kentucky ED + IP discharge datasets …

Patterns And Characteristics Of Gabapentin Use Among Medicare Beneficiaries, Gyeon Oh, Daniela C. Moga, Patricia R. Freeman, Erin L. Abner

Epidemiology and Environmental Health Faculty Publications

Background: Gabapentin is increasingly prescribed to older adults, yet prescribing patterns and characteristics of gabapentin initiators remain unclear. Methods: We conducted a retrospective cohort study of gabapentin initiators using a random sample of age-eligible fee-for-service Medicare beneficiaries (2012–2021) enrolled in Parts A, B, and D. Gabapentin initiators were identified from pharmacy claims. We required 180 days of continuous enrollment (washout period) prior to initiation (index date) for inclusion. We analyzed demographics, healthcare utilization within 3 months of initiation, chronic conditions, medication history during washout period, and patterns of gabapentin use. Subgroup analyses compared initiators by duration of continuous gabapentin use …

Preferences For Harm Reduction Vending Machine Design Among Rural People Who Use Drugs, April M. Young, Tasfia Jahangir, Susan Westneat, Chelsi Cheatom, Amanda Fallin-Bennett, Laura C. Fanucchi, Patricia R. Freeman, Jennifer R. Havens, Hannah K. Knudsen, Kathryn E. Mccollister, Susannah Stitzer, Jack Stone, Peter Vickerman, Melvin D. Livingston

Epidemiology and Environmental Health Faculty Publications

Globally, harm reduction vending machines (HRVMs) have been used for decades to dispense safe injection equipment and other supplies to people who use drugs (PWUD). However, HRVMs have only recently scaled up in the U.S. and few operate in rural settings. This study describes preferences for HRVM design among rural PWUD in two Appalachian Kentucky communities. Peer-referral and outreach were used to recruit participants (n = 731). Eligibility criteria were ≥ 18 years, residing in the target counties, and having used any drug (excluding alcohol, cannabis, and tobacco) to get high within 6 months. Interviewer-administered questionnaires elicited data on behavioral/demographic …

Probing Tau Citrullination In Alzheimer’S Disease Brains And Mouse Models Of Tauopathy, Huimin Liang, Jerry B. Hunt, Chao Ma, Andrii Kovalenko, John Calahatian, Cecelie Pedersen, Haiying Liu, Junyan Li, Malina Serrano, Danielle Blazier, Mallory Watler, Patricia Rocha-Rangel, Christopher Saunders, Laura J. Blair, Leonid Breydo, Kevin Nash, Zainuddin Quadri, Brian Kraemer, Peter Nelson, Christopher Norris, Erin L. Abner, Vladimir N. Uversky, Dale Chaput, Maj Linda B. Selenica, Daniel C. Lee

Epidemiology and Environmental Health Faculty Publications

Alzheimer’s disease (AD) includes a defining hallmark that correlates most closely to cognitive decline, namely misfolded tau protein. However, the “upstream” etiology and downstream clinical manifestations of tauopathies are quite diverse. Tau deposition elicits different pathological phenotypes and outcomes depending on the tau strain, proteoforms, and regional susceptibility. Posttranslational modifications (PTM) can alter tau structure, function, networks, and its pathological sequelae. We uncovered tau citrullination on multiple epitopes caused by peptidyl arginine deiminase (PAD) enzymes. PAD-induced citrullination irreversibly converts arginine residues to citrulline, producing a net loss of positive charge, elimination of pi–pi interactions, and increased hydrophobicity. We observed increased …

Prospective Cohort Study Of Fentanyl Test Strip Use And Distribution In Three States, Janet E. Childerhose, Kitty Gelberg, Rachel Vickers-Smith, Megan E. Dzurec, Emmanuel Oga, Mallory Harris, Rachel Caspar, Denise C. Babineau, Megan E. Hall, Beth S. Linas, Katherine E. Marks, Amanda Fallin-Bennett, Laura C. Fanucchi, Louisa Gilbert, James L. David, Mary Russo, Kathryn E. Lancaster, Soledad Fernandez, Michael Konstan, Redonna K. Chandler, Carter Roeber, Jennifer Villani, Rebecca D. Jackson, Bridget Freisthler, Sharon L. Walsh, Nabila El-Bassel

Epidemiology and Environmental Health Faculty Publications

Background: The Stay Safe Study is the first observational prospective cohort study investigating fentanyl test strip (FTS) use by people who use drugs (PWUD) and distribution by community organizations that provide harm reduction services (e.g., naloxone distribution) in three states (Kentucky, New York, and Ohio). The purpose of this paper is to describe the study design, along with implementation successes and challenges. A related goal is to provide recommendations and encourage researchers to undertake multi-state and multilevel studies of FTS use and distribution. Methods: The Stay Safe Study has one primary, five secondary, and three exploratory objectives. From May-December 2023, …

Referrals And Utilization Of Diabetes Self-Management Education And Support (Dsmes) Among Patients With Type 1 And Type 2 Diabetes At A Regional Medical Center In Kentucky, Omer Atac, George C. Bryant, William B. Burrows, Kory R. Heier, James W. Keck, Key C. Douthitt, Mary E. Lacy

Epidemiology and Environmental Health Faculty Publications

Background: The goal of this study was to examine referral and attendance patterns for diabetes self-management education and support (DSMES) among patients with both type 1 (T1D) and type 2 diabetes (T2D) at a regional medical center in Kentucky, and to identify demographic and clinical factors associated with these outcomes. Methods: We analyzed electronic health records of adults with diabetes (n = 10,587; n = 817 with T1D and n = 9,770 with T2D) who received care from 1/1/2016-12/31/2019 at University of Kentucky HealthCare. We compared DSMES referral and attendance rates by various demographic and clinical factors and used logistic …

Using The Practical, Robust Implementation And Sustainability Model To Identify Implementation Determinants Of A Statewide Diabetes Learning Collaborative In Kentucky, Aaron J. Kruse-Diehr, Borsika A. Rabin, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Russell E. Glasgow, Key C. Douthitt, James W. Keck, Mary E. Lacy

Epidemiology and Environmental Health Faculty Publications

Background: Prevalence of type 2 diabetes (T2D) in Kentucky is among the highest in the United States. Diabetes self-management education and support (DSMES) is an evidence-based intervention that teaches people living with T2D to self-manage their disease but is underutilized in Kentucky despite being available free-of-charge to residents of every county. One promising strategy to improve DSMES utilization is clinic participation in a learning collaborative, wherein participants undertake small tests of change to improve the referral process. The purpose of this study was to identify determinants related to successful implementation of the learning collaborative, as well as perceived progress on …

How Fundraisers Met Goals During The Covid-19 Pandemic, Cody C. Greene

Electronic Theses and Dissertations

The COVID-19 pandemic disrupted nearly every aspect of higher education operations, including fundraising and donor engagement. This qualitative study explored how Vice Presidents for Advancement and other senior fundraising leaders in higher education adapted their practices to meet fundraising goals during the pandemic. Using a narrative design, in-depth interviews were conducted with nine participants representing diverse institutions in the southeastern United States. Braun and Clarke’s (2006) six-phase thematic analysis was used to code and interpret the data.

Seven major themes emerged: communications, technology, donor relations, managing a fundraising team, overall giving impact, successful strategies, and the future. Participants described how …

From Policy To Practice: How Institutional Interpretations Of Ferpa Shape The Campus Safety Conversation, Britney Deaver

Electronic Theses and Dissertations

The Family Educational Rights and Privacy Act (FERPA) is a foundational federal law designed to protect the privacy of student education records. FERPA includes exceptions—such as for health and safety emergencies—that institutions may interpret and apply in varied ways. This qualitative study explores how higher education professionals across diverse institutional contexts conceptualize and apply the health or safety exception, and how those interpretations influence campus safety practices and policy-making. Through semi-structured interviews with compliance officers and administrators, the research examines the intersection of federal policy, institutional culture, and individual judgment.

Findings reveal a range of interpretations shaped by institutional risk …

The Food Truck: A Multi-Product Newsvendor With Expectile Risk, Sekyiwaah Nuamah

Electronic Theses and Dissertations

The Newsvendor Problem is a fundamental model in Operation Research and Supply Chain Management used to determine the optimal order quantity under uncertain demand to minimize expected costs.
This research extends the classical Newsvendor problem to a multi--product setting, addressing the risk of asymmetric cost structures faced by a food truck. This thesis introduces expectile risk measures to quantify and manage uncertainty in demand, moving beyond traditional risk metrics. To evaluate the impact of expectile-based decision-making, we analyze three types of demand distributions--simple, symmetric, and skewed. For skewed distributions, we apply linear spline inverse interpolation to derive expectile values from …

Deep Learning With Kalman Filter, Rexford Julius Quaye

Electronic Theses and Dissertations

This thesis presents an extension of the Kalman filter to handle nonlinear and non-Gaussian systems. The standard Kalman filter is optimal under Gaussian assumptions but struggles with more complex noise models. This work introduces a novel loss function based on the Mahalanobis distance, which incorporates the covariance structure of measurement errors, enabling the filter to adapt to non-Gaussian scenarios. The neural network framework is applied to predict the system’s process model, while retaining the classical Kalman measurement update. The proposed methodology is demonstrated through examples of car position and rocket altitude tracking. The results show that the new approach performs …

Tennessee K-3 Teachers’ Perceptions Of Structured Literacy Curriculum Based On The Science Of Reading: A Phenomenological Approach, Amy L. Reece Townsend

Electronic Theses and Dissertations

The focus of this study was to explore the perceptions and knowledge of Tennessee kindergarten, first-grade, second-grade, and third-grade teachers regarding early literacy and science-based curricula that incorporate the science of reading. This study examined the experiences of kindergarten through third-grade teachers in a Tennessee school district as they transitioned to a structured literacy approach grounded in the science of reading. The goal was to understand how teachers adapted to the new methods, what helped them succeed, and what challenges they faced during the change.

Data collection included in-depth, semi-structured interviews. Analysis of data occurred in three phases: (a) categorization …

Practices To Possibility: A Narrative Inquiry Examining Practices Supporting Post-School Outcomes For Students With Disabilities, Joshua Reese

Electronic Theses and Dissertations

The purpose of this qualitative narrative inquiry was to examine how educators in high-performing districts that met or exceeded state targets for Individuals with Disabilities Education Act (IDEA) post-school outcomes implemented and sustained evidence-based practices to support successful transitions for students with disabilities. Despite decades of legislative mandates and educational reforms, students with disabilities continue to experience disproportionately lower rates of employment, postsecondary education, and independent living compared to their peers. This study sought to identify not only which practices are effective but also how they are operationalized and maintained within school systems.

Two Tennessee districts identified by exemplary performance …

Sexual Assault, Fault And The Charter, Isabel Grant, Janine Benedet

All Faculty Publications

The Canadian Charter of Rights and Freedoms and the criminal law of sexual assault have in many ways grown up together over the last four decades. In this article we examine the impact of the Charter on the fault requirement for sexual assault and sexual offences against children. We argue that the Charter has been used repeatedly to undermine the early gains of feminist law reform and that courts have gone out of their way to avoid the reasonable steps provisions of the Criminal Code. Courts are consistently reluctant to expect men to desist from sexual activity until they have …

To The Editor: Re: "A National Longitudinal Study Of Wellness Curricula In Us Family Medicine Residency Programs And Association With Early Career Physician Burnout"., Emily Bugada

Medical Education Articles

No abstract provided.

To The Editor: Re: Making Progress On Progress Notes., Amelia Chapman

Medical Education Articles

No abstract provided.

Ohio University Faculty Senate Agenda December 1, 2025, Angela Brock

Faculty Senate Agendas

No abstract provided.

The Civic Oath At Saint-Lazare, 1790, John E. Rybolt C.M.

Vincentian Studies

This study presents the French text, English translation, historical context, and a brief analysis of the speech given at Saint-Lazare on the civic oath-taking in support of the 1790 revolutionary government in France, which every adult citizen had to do publicly. At Saint-Lazare, a group of Vincentians and their neighbors assembled in the motherhouse’s chapel for the oath. This very rare and virtually unknown document is in Richardson Library’s special collections at DePaul University in Chicago. Oath-taking was a way of replacing royal legal authority before assemblies of citizens had been formed. By the time of this oath on 7 …

Three Additional Texts From Felix De Andreis, John E. Rybolt C.M.

Vincentian Studies

Three texts add to our knowledge of the work of Felix De Andreis (1778–1820), the founding superior of the Congregation of the Mission in the United States. These have recently come to light. Two are originals, and the third is a copy. They are given in the original languages and in English, with introduction and commentary. The first is an “Indian grammar” with the Lord’s Prayer and catechism by Felix De Andreis, written circa 1817. According to David J. Costa, a scholar in Native American linguistics, it “provide[s] us with the only source of data that is clearly transitional between …

Code Crimson Ob: A Lifeline For Maternal Health, Colleen Cowie, Elizabeth Barrera, Leah Williams-Jones, Mercy R. Banaszak, Leonor Ruiz, Arvinder Singh

Nursing & Health Sciences Research Journal

Introduction: Postpartum hemorrhage (PH) accounts for 12% of maternal deaths in the U.S. and affects approximately 5% of obstetric individuals. Despite available treatments, delays in recognition and response can lead to severe complications or death. The purpose of this evidence-based practice project was to improve maternal outcomes by implementing Code Crimson OB, a specialized obstetric rapid response team (RRT) for managing maternal hemorrhage.

Methods: An unannounced maternal hemorrhage drill revealed critical delays in mobilizing appropriate personnel. In response, the RRT protocol was revised to include Code Crimson OB, ensuring rapid, coordinated intervention. Hospital-wide education was conducted, and the protocol officially …

Implementation Of A Pharmacist-Driven Monitoring Protocol For Individuals Receiving Multiple Qt-Prolonging Medications In Acommunity Hospital, Maria A. Ruiz, Maura Falli, Kristina Lee, Mario Pascual, Radhan B. Gopalani

Nursing & Health Sciences Research Journal

Background: Torsades de pointes is a life-threatening polymorphic ventricular tachycardia, associated with QT interval lengthening on an electrocardiogram. Hospitalized individuals are routinely administered multiple medications with the potential to prolong the QTc interval. This quality improvement project sought to implement a pharmacist-driven protocol to identify and monitor individuals on multiple QT-prolonging medications using pharmacovigilance software, VigiLanz®, and the Tisdale risk score, aiming to reduce adverse drug reactions (ADRs) in a community hospital.

Methods: This was a single-center prospective quality improvement project of individuals admitted to the hospital from February through March 2024. Individuals with two or more scheduled QT-prolonging medications …

A Case Of Monocular Diplopia In The Setting Of High-Grade Urothelial Bladder Carcinoma Treated With Pembrolizumab, Leanne Dumeny, Joana Nuraj, Roshni Bisoondial, Nicole Moscoso, Arvinder Singh, Lorena Bonilla Md

Nursing & Health Sciences Research Journal

Case Presentation: We present the case of a 70-year-old male with a history of highgrade urothelial carcinoma who had been treated with multiple cycles of immune checkpoint treatment, pembrolizumab, presenting to the emergency department with worsening bone pain, abdominal discomfort, and hematuria.

Clinical Course: He reported blurry vision and monocular diplopia in the right eye for the past month. Physical examination revealed an inability to fully track with the right eye along with fatigue-induced diplopia, raising concerns for metastatic or immunotherapy-related ocular involvement. Imaging primarily revealed metastatic disease in the right orbital apex involving the rectus muscles, intraconal fat, and …

From Crisis To Commitment: How Covid-19 Reshaped Motivation In Small Business Organizational Culture, Boone G. Depenbrock

Honors Theses

This study examines how the COVID-19 pandemic reshaped employee motivation and organizational culture in small businesses and explores the role of job characteristics in that process. Using an online survey administered to small business employees and owners, respondents reported their experiences before, during, and after the pandemic across validated measures of motivation, organizational commitment, job satisfaction, goal internalization, turnover intentions, and core job design factors. After data cleaning, 21 responses were analyzed. Results showed statistically significant increases in organizational commitment, job satisfaction, and goal internalization after COVID-19, along with a decrease in turnover intentions. Internal work motivation showed a small, …