Digital Commons Network^™

Chapter 9 Slides: Career Development And Future Opportunities, Lisa Dunkley

Internship, Practicum, and Capstone: A Guide for Health Sciences

No abstract provided.

2024-2025 Annual Report, Stephanie C. Miller

Law Library Annual Reports and Assessments

No abstract provided.

From Quid Post Quo To Quid Pro Quo: Toward An Evidentiary Standard For 18 U.S.C. § 666 After Snyder, Luke Henkel

University of Chicago Law Review

This Comment addresses a question left unanswered by the Supreme Court’s recent decision in Snyder v. United States. Snyder held that the federal funds bribery statute, 18 U.S.C. § 666, covers only bribes, not gratuities. That is, an agreement to exchange payment for an official act by a state or local government official is criminally prohibited (if the official’s agency receives a certain amount of federal funding). But § 666 does not prohibit payments made after official acts so long as there was no agreement to conduct a quid pro quo exchange beforehand. Thus, the key issue in cases with …

Pardoning Corporations, Brandon Stras

University of Chicago Law Review

In 1977, a company convicted of conspiring with the mob asked President Jimmy Carter for a pardon. Government officials speculated that the President could grant the request, but ultimately the President decided that the company did not deserve clemency. Nearly fifty years later, President Donald Trump pardoned a company and commuted the sentence of another. People are again wondering whether the pardon power covers companies, but no one can offer evidence either way.

History shows that the pardon power covers companies. Before the Founding, the King would often pardon corporations. Both the City of London and the Massachusetts Bay Company …

Sincerity Or Substantial Burden? Investigating The Proper Threshold Test For Prisoner Free Exercise Claims, David Wang

University of Chicago Law Review

When prison officials violate the free exercise rights of prisoners, prisoners can seek recourse under 42 U.S.C. § 1983. However, due to the specialized and restrictive nature of prisons, courts adjudicate these claims under a reasonableness test set out in the case Turner v. Safley instead of under a strict scrutiny standard. While circuits agree on using the Turner test for prisoner free exercise claims, there is a deep circuit split on the proper threshold test for these types of claims.

While some circuits hold that inmates need to show that their religious practice was substantially burdened, other circuits hold …

Effect Of Successive Subculturing On Virulence, Growth, And Germination Of Fungus Metarhizium Rileyi For Biological Control Of Fall Armyworm, Joanna Marie E. Valeros, Trisha Anne P. Garcia, Noel G. Sabino, Marcela M. Navasero, Melissa P. Montecalvo

The Philippine Agricultural Scientist

This study explored the impact of successive subcultures of Metarhizium rileyi (Farl.) Kepler, S.A. Rehner & Humber on its cultural traits, spore germination, and virulence against fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), a key pest in agricultural systems. The mass production of infective propagules is essential for effective biological control. Notable changes were observed in the texture and mycelial appearance of the fungus across subcultures. Initially, the fungus exhibited a powdery texture up to the 6th subculture. However, the fungal growth became fluffy and cottony by the 8th and 10th subcultures. Additionally, sporulation rates (7.05 × 10^{8 …}

Graduates List - December 2025, University Of Nebraska At Omaha

Commencement Lists

No abstract provided.

Creating A Virtual Event Website, Timothy Sorensen

Student Projects for Graduate Degrees

This Best of 10 Virtual Race project involved creating a virtual athletic event website designed to motivate participants to engage in multiple types of physical activity while providing a fair and engaging leaderboard system. Traditional virtual events often favor participants who specialize in a single activity, such as cycling or running long distances, making it difficult for multi-sport athletes to compete. This project addressed that gap by implementing a scoring system across multiple categories such as cardio, ball sports, racket sports, weight training, outdoor activities, etc. where lower cumulative scores indicate better overall performance. This approach encourages participants to improve …

Evaluation Of Injection Well Efficacy To Address Saltwater Intrusion In Water Supply Wells At Hooper Bay, Alaska, Matthew Hegland, Thomas Ravens

Student Projects for Graduate Degrees

Saltwater intrusion affects water quality in coastal water supply wells, increasing salinity in drinking water and thereby negatively impacting communities. Hooper Bay, AK is a community in west Alaska that has experienced relatively high salinity water in their water supply wells. Injection wells are evaluated here in an effort to provide a possible solution to further saltwater intrusion in Hooper Bay wells. Analytical modeling is utilized to perform the investigation. Steady-State 2D horizontal models provide potential placement, spacing, and pumping rates for the proposed injection wells.

West Susitna Access Road Project 2025 Cultural Resources Report: Culturally Modified Trees, Nicholas Maness

Student Projects for Graduate Degrees

The Alaska Department of Transportation and Public Facilities (DOT&PF) is undertaking the proposed West Susitna Access Road Project which aims to construct a new road that extends from West Susitna Parkway in Big Lake, Alaska through State Lands west of the Susitna River.  The project would include land clearing and construction of transportation infrastructure across waterways including the Little Susitna River, Fish Creek, Susitna River, and Alexander Creek.

The proposed project footprint lies in the traditional ancestral territory of several Upper Cook Inlet Alaska Native cultures, and project activities have the potential to adversely affect cultural and natural resources in …

Applied Project Management Methodologies To Create A Volunteer Engagement Guide For New Hope Nonprofit Organization's Volunteer Program, Carlos San Miguel

Student Projects for Graduate Degrees

Nonprofit organizations (NPOs) rely on volunteers to sustain operations and fulfill their missions, yet many realize persistent challenges in recruiting, training, and keeping them. New Hope Compassionate Ministries (NHCM), a nonprofit organization in Alaska, has struggled to attract and keep volunteers for inventory and restock days—limitations that directly impact its ability to combat food insecurity. This project applies structured project management methodologies to find and address NHCM’s volunteer engagement gap. Through mixed-methods research, including surveys and interviews, the project analyzes current volunteer recruitment and retention practices to uncover underlying barriers. Findings inform the development of a Volunteer Engagement Guide designed …

Application Of A Nonprofit Project Management Methodology To Solid Rock Bible Camp Infrastructure Planning, Austin Laber

Student Projects for Graduate Degrees

Over the last decade, several costly infrastructure issues have been presented to Solid Rock Bible Camp (SRBC) due to deferred maintenance, poor record-keeping, and short-term, donation-based funding. This has cost the organization substantial time and money and has risked its ability to obtain insurance for its infrastructure. The application of project management principles to SRBC’s unique nonprofit structure and values identified SRBC's current infrastructure needs, pursued future infrastructure solutions, and prioritized future project recommendations. This project documented the campus’s current state and compared its inventory to industry standards and the needs of its stakeholders to find deficiencies. These deficiencies were …

Structural Geology Of The Brady Mountain Area, Ouachita Mountains, Arkansas: Integrating Field Mapping, Geospatial Techniques, Photogrammetry And 3d Modeling For Structural Analysis, Emmanuel Darko, Zachariah Fleming

Electronic Theses and Dissertations

Much of the Ouachita orogenic belt, representing the deformed Paleozoic rocks flanking the southern margin of the North American craton, is buried beneath post-orogenic Mesozoic and Tertiary sediments composing the Gulf Coastal Plain. The Ouachita Mountains of Arkansas and Oklahoma are the largest areas of outcrop for the Pennsylvanian-age Ouachita orogenic belt, making it an ideal place to study the orogeny. This study focuses on the Brady Mountain area within the Benton Uplift, the orogenic core of the Ouachita Mountains in western Arkansas. The region is comprised of numerous ridges trending nearly east-west and are for the most part densely …

Drivers Of Ecosystem Respiration In The Middle Rio Grande Floodplain Aquifer, Eva Tipps

Biology ETDs

Little is known about carbon flux and ecosystem metabolism in river floodplains, despite their potentially large and dynamic contributions to carbon storage and loss. We hypothesized that the region of intermittent saturation (ROIS), which is the subsurface interface between terrestrial and aquatic ecosystems, is a biogeochemical ‘hotspot’ for ecosystem respiration and carbon transformation. Groundwater depth and variability in the ROIS facilitate interactions between aquatic and terrestrial processes, but their role in carbon fluxes is poorly understood. We developed a novel method utilizing high-frequency sensors in groundwater wells to capture biogeochemical ‘hot moments’ of ecosystem respiration in the ROIS of the …

Evaluating Intersectional Variation Of Hpv-Associated Cancers In Rural America, Jason Semprini, Gabriel A. Benavidez, Whitney E. Zahnd, Heather M. Brandt

Public Health

Purpose: For decades, incidence of human papillomavirus (HPV)-associated cancers has been increasing in rural communities across the United States. Although emerging evidence shows a widening rural-urban disparity, rural intersectionality has been understudied. Our study examined the incidence of HPV-associated cancers within rural communities to identify differences by race/ethnicity for males and females, and explore how these differences varied by cancer type, socioeconomic, and geographic factors.

Methods: We accessed age-adjusted cancer incidence rates (2010–2019) from the North American Association of Central Cancer Registries (NAACCR) for HPV-associated cancers (cervical, vaginal, vulvar, penile, anal, oropharyngeal) in rural counties. Stratifying by sex, we calculated …

Platforming For Circuit Education, Grady Oliver Schneider

Computer Engineering

The purpose of this project was to provide an alternative for students being introduced to resistive circuits. As a freshman in electrical engineering (transferred to computer engineering), I saw the struggles of other freshman to grasp the conceptual basics of circuits. While there’s lots of guides to circuit education, I think many of them fall short of being both engaging and teaching the intuition behind circuits. A lot of the more advanced concepts in circuits depends on the basic intuition of KCL, KVL, and Ohm’s Law. While there’s several basic techniques (such as voltage divider, current divider, and mesh current …

Digital Solutions For Bridging Language Barriers: Designing And Testing An App For Construction Spanish Safety Communication On Construction Jobsites, Adrian Cappella

All Theses

Language barriers between English-speaking supervisors and Spanish-speaking workers create safety risks on U.S. construction jobsites. Hispanic workers face higher injury and fatality rates, with miscommunication being a major contributing factor. Existing translation tools lack the accuracy, cultural context, and jobsite relevance needed for effective safety communication.

In this study a mobile application with construction-specific safety phrases in English and Spanish was designed and field tested. The research included a literature review, phrase collection and validation with industry experts, application development and design with a computer science collaborator, and usability testing with supervisors and workers. Surveys and field trials measured navigation, …

Caring For Others And Self Care: Examining “Good” Care Among The Older Vietnamese Community In San José, California, Chloe Nguyen

Master's Theses

In this thesis, I present a study of the older Vietnamese community in San José, California. I explore the concept of "good" care through the anthropology of care, a conceptual framework that examines how care is understood and practiced across different cultural and social contexts. Using ethnographic methods, such as interviews and participant observation, I examine caregiving practices and experiences, as well as community members' perceptions of what constitutes "good" care. I draw on concepts of "good" care, reciprocal caregiving, and self-care to analyze themes that emerge from their caregiving practices and experiences. I also discuss caregiving at a distance …

Utilizing Functional Neuroimaging To Study Early Language Development, Halie A Olson, Trevor K M Day, Kelly J Hiersche, Brittany L Manning, Holly Bradley, Soujin Choi, Gavkhar Abdurokhmonova, Sarah A Mccormick, Amy L Conrad, Dustin Scheinost, Kelly A Vaughn

Faculty, Staff and Student Publications

Language develops rapidly over the infant and toddler period and has been a key area of research within the field of developmental cognitive neuroscience. Understanding the neural basis of early language development may help us predict delays or disorders, recommend early interventions, and provide a deeper mechanistic understanding of how the brain supports language learning. While the ontogeny of many cognitive functions can be studied in animal models, language development can only be studied in human children. Thus, functional neuroimaging is critical for uncovering the neural basis of language in early development. The purpose of this review is to take …

Earnings, Ethics, And Fast Fashion: How Does Income Affect Consumers’ Decisions?, Ava M. Minton

All Theses

This thesis examines if annual earnings influence consumers’ likelihood of avoiding clothing brands associated with labor exploitation. To examine this question, the study draws on four major U.S. datasets that together capture two decades of consumer attitudes and self-reported behaviors. The results show that income has a strong and statistically significant effect: household income increases the odds of avoiding exploitative brands by roughly 27 percentage points. Education, ideology, and gender also exhibit meaningful positive associations with ethical consumption, while age slightly reduces the likelihood of boycott participation. Overall, the analysis provides evidence that ethical consumption behaves like a normal good …

Capillary Imbibition Of Shear-Thinning Xanthan Gum Solutions, Aimee Sayster

All Theses

Capillary rise in confined geometries plays a critical role in numerous natural and industrial processes. While classical models such as the Lucas–Washburn equation accurately describe the dynamics of Newtonian fluids, they fail to capture the complex behavior of shear-thinning, non- Newtonian fluids whose viscosity varies with shear rate. This research investigates the capillary rise dynamics of shear-thinning xanthan gum polymer solutions in capillary tubes. The rheological behavior of each fluid is characterized using the Ellis model, which accounts for shear-thinning effects through three key parameters: zero-shear viscosity μ0, characteristic shear stress τ1/2 and viscosity index α. Experimental data was collected …

Impact Of Antibody Fc Engineering On Translational Pharmacology, And Safety: Insights From Industry Case Studies., Frank R Brennan, J Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Tilman Schlothauer, Shirley J Peters, Curtis C Maier, Changhua Ji, David L Wensel, Derrick Witcher, Patricia C Ryan, T Scott Manetz, Adriano Flora, Brian Soper, Birgit Fogal, Lindsey Dzielak, Xiaoting Wang, Prathap Nagaraja Shastri, Karen Price, Michael Doyle, Nidhi Sharda, Mary Struthers, Maximilian Brinkhaus, Bianca Balbino, Eric Stefanich, Masaki Honda, Jan Terje Andersen, Shermaine Mitchell-Ryan, David P Humphreys

Faculty Research 2025

Therapeutic monoclonal antibodies (mAbs) are often designed to not only bind targets via their antigen-binding domains (Fabs) but to also engage with cell surface receptors, FcγRs and FcRn, through their Fc regions, which may result in a variety of functional outcomes, including antibody- dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) and alteration of circulating half-lives. Engineering the Fc regions to achieve desirable pharmacology and pharmacokinetics is a widely adopted strategy in drug development. Fc regions can be modified through amino acid substitutions and glycoengineering, resulting in enhanced or reduced effector functions, preferential binding to FcR subtypes, …

Molecular Systems Biology At 20: Reflecting On The Past, Envisioning The Future., Poonam Bheda, Jingyi Hou, Ruedi Aebersold, Uri Alon, Joel S Bader, Lee Bardwell, Edison Liu, James C W Locke, Matthias Mann, Andrew J Millar, Felix Naef, Yitzhak Pilpel, Ron Shamir, Dennis Vitkup

Faculty Research 2025

As Molecular Systems Biology marks its 20th anniversary, we take this moment to reflect on two decades of discovery and innovation. Since its launch, the journal has stood at the forefront of integrating quantitative biology, computational modeling, and systems science—helping to shape how we understand complex biological systems.

Rna Binding Of Gapdh Controls Transcript Stability And Protein Translation In Acute Myeloid Leukemia., Sama Shamloo, Jeffrey L Schloßhauer, Shashank Tiwari, Kim Denise Fischer, Omar Almolla, Yohana Ghebrechristos, Lisa Kratzenberg, Aathma Merin Bejoy, Ioannis Aifantis, Francesco Boccalatte, Eric Wang, Jochen Imig

Faculty Research 2025

Dysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells. In acute myeloid leukaemia (AML) RBPs are key regulators of tumour proliferation. While classical RBPs have defined RNA binding domains, RNA recognition and function in AML by non-canonical RBPs (ncRBPs) remain unclear. Given the inherent complexity of targeting AML broadly, our goal was to uncover potential ncRBP candidates critical for AML survival using a CRISPR/Cas-based screening. We identified the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a pro-proliferative factor in AML cells. Based on cross-linking and immunoprecipitation (CLIP), we are defining the global targetome, detecting novel RNA targets mainly …

Low-Coverage Whole-Genome Sequencing Facilitates Accurate And Cost-Effective Haplotype Reconstruction In Complex Mouse Crosses., Samuel J Widmayer, Lydia K Wooldridge, Emily Swanzey, Mary Barter, Chrystal M Snow, Michael C Saul, Qingchang Meng, Beth L Dumont, Laura G Reinholdt, Daniel M Gatti

Faculty Research 2025

The search for the underlying genetic contributions to complex traits and diseases relies on accurate genetic data from populations of interest. Outbred populations, like the Diversity Outbred (DO), are commonly genotyped using commercial SNP arrays, such as the Giga Mouse Universal Genotyping Array (GigaMUGA). However, array genotypes are expensive to collect, subject to significant ascertainment bias, and too sparse to capture the genetic structure of highly recombined mouse crosses. We investigated the efficacy of sequencing-based genotyping by comparing genotyping results between the GigaMUGA, double-digest restriction-site associated DNA sequencing (ddRADseq), and low-coverage whole-genome sequencing (lcWGS). We aligned reads at ~ 1× …

Harmonizing Mouse Anatomy Terminology: A Common Language?, Jesús Ruberte, Paul N Schofield, John P Sundberg, Sergi Olvera-Maneu, Ana Carretero

Faculty Research 2025

The mouse remains the principal animal model for investigating human diseases due, among other reasons, to its anatomical similarities to humans. Despite its widespread use, the assumption that mouse anatomy is a fully established field with standardized and universally accepted terminology is misleading. Many phenotypic anatomical annotations do not refer to the authority or origin of the terminology used, while others inappropriately adopt outdated or human-centric nomenclature. This inconsistency is further exacerbated by the limited availability of comprehensive anatomical references, often compelling researchers to rely on "do-it-yourself" anatomical interpretations when characterizing disease models-an approach that increases the risk of inaccuracies …

Single-Cell Landscape Of Sex-Specific Drivers Of Alzheimer's Disease., Yiyang Wu, Kyle J Travaglini, Mariano Gabitto, C Dirk Keene, Amy R Dunn, Catherine C Kaczorowski, Philip L De Jager, Vilas Menon, Julie A Schneider, David A Bennett, Logan Dumitrescu, Timothy J Hohman

Faculty Research 2025

INTRODUCTION: We investigated sex-specific gene expression associations with the neuropathology and cognitive manifestation of Alzheimer's disease (AD) leveraging single-nucleus transcriptomic datasets including 2.84 million nuclei from the dorsolateral prefrontal cortex (DLPFC).

METHODS: We delineated the full scope of sex-specific transcript associations, differential gene expression, signaling pathway, and cell-cell communication network changes in eight major DLPFC cell types.

RESULTS: Nine female-specific associations were identified and replicated, involving ADGRV1, OR3A3, IFI27L1, LYRM1, STAP2, TSTD2, PDYN, and TMEM50B. We observed the preponderance of protective female-specific associations in neurons. Sex-specific genes were enriched in the immune-, inflammation-, and damage-related stress-response pathways. Six ITGB1-mediated microglia-specific …

Pak1 Inhibitor Nvs-Pak1-1 Preserves Dendritic Spines In Amyloid/Tau Exposed Neurons And 5xfad Mice., Tao Yang, Hasi Huhe, Sean-Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Zachary W Davis-Gilbert, Gregory Cary, Carolyn Paisie, Robert R Butler, Jesse Wiley, Ranjita Betarbet, Haian Fu, Duc Duong, Nicholas T Seyfried, Karina Leal, Gregory W. Carter, Aled Edwards, Allan I Levey, Jacob L Capener, David H Drewry, Mohammad A Hossain, Hans J Oh, Alison D Axtman, Stacey J Sukoff Rizzo, Frank M Longo, The Emory-Sage-Sgc-Jax Treat-Ad Center

Faculty Research 2025

INTRODUCTION: Synaptic spine loss in Alzheimer's disease (AD) contributes to cognitive decline. p21-activated kinase 1 (PAK1), a regulator of spine integrity, is aberrantly activated in AD. We investigated whether PAK1 inhibition might preserve dendritic spines in vitro and in vivo.

METHODS: Oligomeric amyloid beta (oAβ) or tau (oTau) were applied to hippocampal neurons ± NVS-PAK1-1, a selective PAK1 inhibitor. NVS-PAK1-1 was orally administered to 5xFAD mice. The effects of NVS-PAK1-1 treatment on PAK1 activity, spine density, and the proteome were assessed using phospho-PAK1 (pPAK1) western blotting, Golgi staining, and mass spectrometry for proteomic analyses.

RESULTS: NVS-PAK1-1 prevented oAβ and oTau-induced …

The Recombinant Zoster Vaccine Induces Trained Immunity In Monocytes Through Persistent Downregulation Of Tgfβ., Michael J Johnson, Megan Crotteau, Debashis Ghosh, Thao Vu, Luke Trinity, Radu Marches, Duygu Ucar, Myron J Levin, Adriana Weinberg

Faculty Research 2025

Older adults have decreased vaccine efficacy, but the adjuvanted recombinant VZV-gE zoster vaccine (RZV) is highly efficacious. We investigated memory-like innate immune responses after RZV and after the zoster vaccine live (ZVL), which is much less efficacious. RZV increased NK, monocyte, and DC activation in response to in vitro VZV-gE stimulation for up to 5 years post-vaccination, while ZVL increased only DC responses to VZV for up to 90 days. In purified monocyte and NK cell cocultures, RZV recipients showed increased responses to VZV-gE, HCMV and HSV antigenic stimulation post-vaccination. ATAC-seq analysis of purified monocytes revealed decreased accessibility in areas …

Integrated Phenotypic And Proteomic Screening Identifies Top-Tier Alzheimer's Disease Therapeutic Targets., Gregory Cary, Qianjin Li, Jesse C Wiley, Carolyn Paisie, Yuhong Du, Elizabeth L Zoeller, Duc Duong, Haian Fu, Nicholas T Seyfried, Allan I Levey, Ranjita Betarbet, Gregory W. Carter, The Emory-Sage-Sgc-Jax Treat-Ad Center

Faculty Research 2025

INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck.

METHODS: We applied an integrative screening framework to assess 29 candidate targets from risk-enriched biological domains. Using disease-relevant murine BV2 microglial cell lines with stable Psen2 knockdown, we performed small interfering RNA-mediated perturbations followed by cellular phenotypic assays and quantitative proteomics.

RESULTS: Twenty-five candidate targets significantly altered at least one phenotype, with stronger effects in Psen2 knockdown cells. Integrated proteomic analyses identified several perturbations that reversed AD-associated molecular patterns. Five targets-Ap2a2, Pdhb, …