Digital Commons Network^™

Potential Of Chitosan-Encapsulated Mango Leaf Extract Oemulsion As Fruit Packaging, Panji Setya Utama Putra, Damar Rastri Adhika, Lia Amelia Tresna Wulan Asri

Chimica et Natura Acta

Fruits have a relatively short shelf life. One of the extensively researched preservation methods for fruits is edible coating. Edible coating is a method of coating food products with a polymer layer. Considering the environmental and sustainability aspects, edible coatings were synthesized from biodegradable polymers derived from polysaccharides. Chitosan is a widely developed and researched type of biopolymer due to its antimicrobial activity. In addition to antimicrobial activity, antioxidant properties are important in food packaging applications. Mango leaves (Mangifera indica L.) contain various secondary metabolites that play a role in antioxidant activity, such as mangiferin, gallic acid, flavonoids, and gallotanin. …

Study And Characterization Of Nitration Of Isovanillic Acid Derivatives Using Nmr And Mass Spectroscopy, Elvira Hermawati, Pipih Lutfi Sa'adah, Ade Danova, Didin Mujahidin, Iqbal Musthapa

Chimica et Natura Acta

Isovanillic acid and its derivatives serve as precursors in the synthesis of EGFR tyrosine kinase inhibitors, which are used to treat cancer cell lines. A crucial step in this process is the nitration of isovanillic acid through nucleophilic aromatic substitution, resulting in 6-nitroisovanilic acid and its derivatives, which act as intermediates for forming a quinazolinone ring. However, this study revealed that direct nitration of isovanillic acid derivatives led to unexpected products, such as 3-hydroxy-4-methoxy-2,6-dinitrobenzoic acid (1) and 4-(3-(2-methoxy-4-nitrophenoxy)propyl)morpholine (4). Additionally, the optimal conditions for etherification of 2 with N-(3-chloropropyl)morpholine to produce 3 involved using Cs2CO3 in DMF and refluxing for …

In Silico Approach Of Flavonol In Hibiscus Sabdariffa As Proteasome Inhibitors Targeting The Ubiquitin-Proteasome Pathway, Nur Amalia Choironi, Syakhsiyatunnisa Galuh Prameswari, Hanif Nasiatul Baroroh

Chimica et Natura Acta

Multiple myeloma is a blood cancer characterized by the abnormal proliferation of B cells that accumulate in the bone marrow. The proliferation of these cells depends on the role of the proteasome through the ubiquitin-proteasome pathway to degrade proteins that regulate the cell cycle, apoptosis, and stress response. The proteasome is the main target of proteasome inhibitors for the treatment of multiple myeloma. Flavonoid compounds in Hibiscus sabdariffa flowers, such as isoquercitrin, quercitrin, quercetagetin, isorhamnetin, and astragalin, have the potential to act as proteasome inhibitors. The insilico study aims to determine the potential of these compounds as proteasome inhibitors based …

Exploring The Synergistic Effect Of Curcumin On Gelatin Films For Real-Time Pork Freshness Assessment, Risna Erni Yati Adu, Gebhardus Djugian Gelyaman, Kristoforus Wilson Kia, Emirensiana Oki, Maria Desi Silab, Angelina Knaofmone

Chimica et Natura Acta

A smart film based on hydromethanol-curcumin has been developed as a freshness detector for local packaged pork. It was fabricated using solution casting method by varying the curcumin content to determine its effect on the chemical, physical, mechanical and functional characteristics of the film. Film characteristics were determined using colorimeter, TGA, FTIR, SEM and bioactivity assay. Film response was analyzed in different pH buffer solutions, different acid base media and pork samples during the storage period. Film characteristics such as antioxidant, antibacterial activity and surface color was improved by increasing curcumin concentration. On the other hand, mechanical dan physicochemical characteristics …

Network Pharmacology Of Ki Encok (Plumbago Zeylanica Linn) Plant As A Treatment For Osteoarthritis, Mitayani Purwoko, Trisnawati Mundijo, Yoshiko Widyadi

Chimica et Natura Acta

One of the plants in Indonesia used by the community to treat gout or Osteoarthritis (OA) is the Ki Encok plant (Plumbago zeylanica Linn). However, it is currently unknown what active substances play a role in the therapy process for gout or OA and what the pathway is. This study aimed to predict the pharmacological mechanism of the active content of Encok leaves against OA disease. This study used an in silico experimental test. The content of active plant substances was extracted from IMPPAT and KNAPSACK. Then, the target proteins of all these active substances were searched for, including target …

A Systematic Review Of Teaching And Learning In The Context Of Arabic Diglossia, Hanada Taha Thomure, Haitham Taha, Taline Sabella, Rabab Saleh

All Works

Arabic is a diglossic language in which standard Arabic coexists with diverse spoken varieties, posing distinct challenges for language acquisition and instruction. Understanding how this context shapes bib_meiseles_1980 educational outcomes is essential for improving Arabic language teaching and learning. Following PRISMA guidelines, we searched eight education and social science databases, and relevant grey literature (1970–2021), screening 927 Arabic and English records and including 101 studies. Descriptive review synthesis identified five recurring themes: Diglossic distance, achievement gap, prestige and attitudes, policy, and exposure to Standard Arabic, including parental engagement. Recommendations relevant for educators, policymakers, and researchers include curriculum strategies include integrating …

Taking Proximate Causation Seriously: Moderating Felony Murder Injustice When The Killer Is On The Other Team, Maria T. Kolar

Seton Hall Law Review

No abstract provided.

Online Decision Mamba, Trenton W. Ruf

Dissertations and Theses

Online in-context reinforcement learning enhances offline-trained policies through online fine-tuning. We introduce Online Decision Mamba (ODM), an architecture that replaces the attention mechanism in Online Decision Transformers (ODT) with the Mamba module to improve long-context sequence modeling and overall RL performance. We performed in-depth evaluations on MuJoCo (OpenAI Gym) and Atari benchmarks, comparing ODM against state-of-the-art offline and online baselines—including Decision Mamba (DM) and ODT. Our results show that ODM achieves competitive or superior performance, with particularly robust gains when initial datasets lack expert demonstrations. In the Qbert Atari environment, ODM shows context-length sensitivity similar to offline DM; however, we …

In-Silico Test Of Myricetin, Phyllanthin, Luteolin Compounds Against Sars-Cov-2 Proteins, Vidia Noviyanti, Nuha Haifa Arifin, Hayu Ikfini, Rifki Febriansah

Pharmaceutical Sciences and Research

Coronavirus disease 2019 (COVID-19), which emerged in late 2019 and was first detected in Indonesia in March 2020, has significantly reshaped the country’s public health landscape. Aside from the viral outbreak itself, a decline in immunity among the population due to excessive concern about the pandemic has also become a significant issue. This study aimed to evaluate the potential of myricetin, phyllanthin, and luteolin compounds as inhibitors of the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) virus by targeting the main protease and spike glycoprotein receptor-binding domain proteins through in silico molecular docking. Remdesivir and favipiravir were used as comparison …

I Can’T Believe It’S Not Social: Investigating The Relationship Between Loneliness, Parasocial Relationships, And Potential Moderators, Hannah I. Suozzi

Master's Theses

Increased loneliness trends coincide with increased media use. Media is turned to as a source of comfort and distraction from the real world. There is cause to believe that people also use media as a way to form parasocial relationships (PSRs), one-sided relationships audiences form with media figures (i.e., celebrities, influencers, and fictional characters). The connection between loneliness and PSR is thought to be moderated by social vulnerability, particularly the need to belong (NTB) and ethnicity. The medium from which PSRs originate lacks empirical study. To address the limitations, this study analyzed data collected from San Jose State University students …

The Scandal Of The Incarnation, Donald Roth

Faculty Work Comprehensive List

"Humanity has always longed for a connection to something higher. Most religions offer some way to transcend the physical, and Christians have often shared that longing."

Posting about ­­­­­­­­the incarnation of Christ from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

The Scandal of the Incarnation

Robust Anomaly Detection Under Data Imbalance, Noise, And Label Scarcity, Zahra Salekshahrezaee

Electronic Theses and Dissertations

In today’s data-driven landscape, large volumes of data are generated continuously, often containing imperfections such as noise, missing data, or unreliable labeling. These real-world datasets are typically high-dimensional, sparsely labeled, and imbalanced, creating substantial challenges for both supervised and unsupervised learning. These challenges are especially prevalent in the task of anomaly detection, where instances belonging to the class of interest are rare and underrepresented compared to normal instances. This dissertation proposes and evaluates robust frameworks for anomaly detection that address these data challenges and improve model performance and robustness using real-world datasets, including credit card transactions and cognitive assessments. Supervised …

Culturally Responsive Assessment And Mtss Toolkit For Multilingual Learners, Morgan Kaltz

Masters Projects

English Learners (ELs) are often assessed using tools that fail to account for their linguistic and cultural backgrounds, leading to inaccurate conclusions about their academic abilities. This project addresses the problem of non–culturally responsive assessment by developing a framework and resources to help teachers design and implement assessments that more accurately reflect what multilingual learners know and can do. Rooted in the principles of Culturally Responsive Assessment (CRA) and aligned with the WIDA English Language Development Standards, this project supports educators in integrating language development with equitable instructional practices.

The project includes creating teacher-friendly tools, such as culturally responsive assessment …

Rare Epigenetic Alterations Are Conserved Across Hematopoietic Differentiation Stages After Mycobacterial Infection, Brandon T Tran, Pamela N Luna, Ruoqiong Cao, Duy T Le, Apoorva Thatavarty, Laure Maneix, Bailee N Kain, Scott Koh, Andre Catic, Katherine Y King

Faculty, Staff and Students Publications

Infection leads to durable cell-autonomous changes in hematopoietic stem and progenitor cells (HSPCs), resulting in production of innate immune cells with heightened immunity. The mechanisms underlying this phenomenon, termed central trained immunity, remain poorly understood. We hypothesized that infection induces histone modifications leading to changes in chromatin accessibility that are conserved during differentiation from HSPCs to myeloid progenitors and monocytes. We conducted genome-wide surveillance of histone marks H3K27ac and H3K4me3 and chromatin accessibility in hematopoietic stem cells, multipotent progenitor 3, granulocyte-monocyte progenitors, monocytes and macrophages of naïve and Mycobacterium avium infected mice. Interferon signaling pathways and related transcription factor binding …

Circulating Tumor Dna Refines Risk Stratification Of Neoadjuvant Therapy-Resistant Breast Tumors, Mark Jesus M Magbanua, Nayelis A Manon, Denise M Wolf, Samuel Rivero-Hinojosa, Ziad Ahmed, Rosalyn W Sayaman, Antony Tin, Derrick Renner, Ekaterina Kalashnikova, Lamorna Brown-Swigart, Gillian L Hirst, Christina Yau, Wen Li, Claudine Isaacs, Rebecca A Shatsky, Amy S Clark, Alexandra Zimmer, Amy L Delson, Angel Rodriguez, Minetta C Liu, Paula R Pohlmann, Laura J Esserman, Hope S Rugo, Angela Demichele, Laura Van 'T Veer

Faculty, Staff and Student Publications

Early-stage breast cancers resistant to neoadjuvant therapy (NAT), characterized by high residual cancer burden (RCB) after treatment, have an increased risk of metastatic recurrence. Here, we show that circulating tumor DNA (ctDNA) detected using a tumor-informed test (1) can improve risk stratification of patients with NAT-resistant tumors (RCB-II/RCB-III) and (2) predict response to NAT. Stratification using ctDNA status at pretreatment or post-NAT and ctDNA dynamics identified NAT-resistant tumors with a significantly decreased risk of metastatic recurrence. ctDNA clearance as early as week 3 across receptor subtypes predicted favorable responses to NAT, including immunotherapies. Interestingly, less than a fifth of patients …

Single Cell Spatial Profiling Of The Matrisome Identifies Region-Specific Adhesion And Signaling Networks In Glioblastoma, Arpan De, Santiago A Forero, Ali Pirani, John E Morales, Marisol De La Fuente-Granada, Sumod Sebastian, Jason T Huse, Leomar Y Ballester, Jeffrey S Weinberg, Frederick F Lang, Kadir C Akdemir, Joseph H Mccarty

Faculty, Staff and Student Publications

The human brain contains a milieu of extracellular matrix (ECM) components that promote normal development and physiology. ECM signaling pathways are often dysregulated in brain pathologies including the malignant cancer glioblastoma (GBM). Here, we used single-cell spatial transcriptomic platforms to map the expression of nearly 400 ECM genes in matching non-cancerous brain and GBM samples. At least four different GBM cell populations have been identified that show unique ECM expression profiles and spatial enrichment in distinct intratumor regions. Spatial mapping demonstrates largely non-overlapping expression signatures of ECM components in GBM stromal cell types, particularly in vascular endothelial cells and microglia/macrophages. …

Friends Of Wheeler Home, Project Correspondence, Milly Wright

Correspondence

Correspondence between Milly (with unlisted last name but likely to be Wright based on other collection contents) and William Lindsey McDonald concerning her gratitude for his support of the Wheeler Home restoration project.

Transcription

[page 1]

Card Front

[page 2]

28 Sandra Lane

Athens, AL 35611

January 8, 1996

Dear Bill,

How can I begin to thank you for the stalwart support that you have given me during these many years that we have struggled to get the Wheeler project moving? Your constancy and commitment are an inspiration to all of us.

As we move to a different level of …

Military Ai And The Specter Of The Limitless War, Yuval Shany, Yahli Shereshevsky

International Law Studies

Legal and extra-legal factors related to the development of international humanitarian law (IHL) support the exercise of strategic restraint during armed conflicts. We claim, however, that technological developments in the area of military artificial intelligence (AI) fundamentally do away with many of the technological constraints that limited the capacity of militaries to fully utilize the “license to kill” afforded to them by IHL. Such a violence-enhancing effect can become even more dramatic in cases where other restraining factors are less effective. The upshot of our analysis is that the implicit assumption that IHL would be applied in a context of …

2025-12-09 Feedback Data From Survey, Morehead State University. Staff Congress.

Staff Congress Records

Feedback data from the Staff Congress survey submitted on December 9, 2025.

2025-12-09 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from December 9, 2025.

Running From The Headlines: Evaluating Levels Of News Consumption Attitudes Across Generations, Andrew Francis

Honors Theses

The primary goal of this research is to answer the question "What behavioral trends exist across various generations and other demographics when it comes to how people consume and interact with news coverage?" With newspapers and other traditional mediums for news consumption being largely phased out of our increasingly digital society, it is important for communicators and journalists to have a comprehensive understanding of how to best reach members of their desired audience. I have studied the data collected and analyzed what trends are apparent in the survey's sample size, which can hopefully be applied to the larger population. To …

Nktr-255 Enhances Complete Response Following Cd19 Car T-Cell Therapy In Patients With Relapsed/Refractory Large B-Cell Lymphoma, Sairah Ahmed, John Dipersio, Et Al.

2020-Current year OA Pubs

No abstract provided.

Deep Profiling Of Human T Cells Defines Compartmentalized Clones And Phenotypic Trajectories Across Blood And Tonsils, Suhas Sureshchandra, Elizabeth Levendosky, Allyssa Daugherty, Samuel J H Murphy, Chandrani Thakur, Naresha Saligrama, Et Al.

2020-Current year OA Pubs

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed on peripheral blood. We performed single-cell sequencing of 5.7 million T cells from autologous blood and tonsils of ten donors. We identified distinct patterns of clonal expansion associated with tonsil-restricted phenotypes. Clonal sharing between blood and tonsils was lower than previous estimates and increased with age. Identical T cell receptor (TCR) sequences exhibited limited concordance in their phenotypes across compartments. Furthermore, location dictated the frequencies, clonal dominance, and phenotypes of antigen-specific T cells. Using immune organoids, we showed that antigen exposure drives functionally distinct …

An Exploratory Evaluation Of The Kalamazoo River Watershed Council: Assessing Organizational Impact And Value, Alexander Mendez

Honors Theses

The Kalamazoo River Watershed Council (KRWC) plays a central role in protecting, restoring, and promoting the long-term health of the Kalamazoo River watershed, a geographically expansive and ecologically complex system facing persistent challenges from legacy contamination, nonpoint source pollution, land-use pressures, and inequitable access to watershed resources. This honors thesis presents an exploratory organizational evaluation of the KRWC, assessing its role and relevance within the watershed, the effectiveness of its programs and partnerships, the strengths and limitations of its governance structure, and opportunities to strengthen its long-term sustainability and impact.

Guided by principles of Practical Participatory Evaluation (PP-E) and Fourth …

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …

Identifying Stable Parental Lines For Stripe Rust Resistance In Soft Red Winter Wheat, Ehsan Shakiba, David Moon

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Stripe rust, caused by Puccinia striiformis f. sp. tritici, continues to be a major challenge in soft red winter wheat (SRWW) production, especially in the southern United States. In this area, mild winters and wet springs frequently lead to early and severe disease outbreaks. Although many lines demonstrate resistance in a single season, that resistance often does not last across multiple years. For breeding programs, this variability makes it hard to identify truly reliable lines. In this study, we evaluated 111 SRWW breeding lines over three consecutive growing seasons (2021-2024) under artificial inoculation in field conditions in Fayetteville, Arkansas. Stripe …

Comparative Analysis Of Color, Texture, And Water Content In Three Shallot Cultivars At Different Harvest Ages, Rahma Wati Lestari, Kusumiyati, Syariful Mubarok

Jurnal Kultivasi

Shallots are a major horticultural commodity with high economic value. The quality of shallots is determined not only by the quantity of the harvest but also by physical characteristics such as bulb color, texture, and water content. This study aims to evaluate the differences in these physical parameters in three popular local cultivars: Brebes, Sumenep, and Tuktuk, harvested at 56, 63, and 70 days after planting (DAP), respectively. This research uses a Randomized Block Design consisting of 9 treatment combinations and analyzed using the SmartstatXL application. Color measurements are conducted using the CIELAB method and converted to CIELCH and RGB …

Analysis Of Source–Sink Organ Dynamics In Kaffir Lime (Citrus Hystrix Dc.) At Different Plant Ages, Siti Auliya Rahma, Rahmat Budiarto, Syariful Mubarok

Jurnal Kultivasi

Kaffir lime (Citrus hystrix DC.) is a leafy spice commodity widely used as a culinary ingredient, in bio-pharmaceuticals, and as a raw material for essential oil production. Despite its high demand, leaf productivity remains relatively low, highlighting the need for improved cultivation practices. A better understanding of source–sink dynamics is essential, as leaf production is strongly influenced by the balance between assimilate-producing and assimilate-consuming organs. Therefore, this study aimed to evaluate the source-sink capacity of kaffir lime plants of different ages as a preliminary step toward identifying cultivation strategies to enhance leaf production. The experiment was conducted at Bale Tatanen …

Biological Parenthood Rates Among Men With Sickle Cell Disease, Anyssa N Young, Sarah R Hayford, Sapuni S Chandrasena, Sara Conroy, Tanvi P Karkare, Barbara L Kroner, Allison King, Robert M Cronin, Luca Badolato, Leena Nahata, Susan E Creary

2020-Current year OA Pubs

No abstract provided.

Glycoside Hydrolase-Mediated Glucomannan Catabolism In Segatella Copri, A Target Of Microbiota-Directed Foods For Malnourished Children, Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Michael J Barratt, Jeffrey I Gordon, Et Al.

2020-Current year OA Pubs

Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation produced superior ponderal and linear growth compared to a standard ready-to-use supplementary food. Subsequent analyses disclosed several candidate bioactive polysaccharides in the MDCF and their bacterial targets, notably strains of