Digital Commons Network^™

Hippo Signaling Regulates Cuticle Pigmentation And Dopamine Metabolism In Drosophila, Shelley B Gibson, Samantha L Deal, Ye-Jin Park, Bo Sun, Yanyan Qi, Jung-Wan Mok, Hyung-Lok Chung, Hongjie Li, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

Pigmentation plays multiple important roles in development, physiology and evolution. Melanization of the insect cuticle requires dopamine as a precursor of melanin and involves key enzymes in dopamine biosynthesis including Tyrosine hydroxylase (TH) and Dopa decarboxylase (Ddc). Some studies have hinted that disruption of the evolutionarily conserved Hippo signaling pathway, which has been primarily studied in the context of tissue growth, may lead to changes in cuticle pigmentation in the fruit fly Drosophila melanogaster. However, to our knowledge, there have not been any systematic investigations into their potential mechanistic links. In this study, we identified that all genes that comprise …

Promotion Architecture: A Deal Fairness Model Of Restricted Price Promotions, Shangwen Yi, David Hardisty, Dale Griffin, Thomas Allard

Research Collection Lee Kong Chian School Of Business

This research examines the effectiveness of two common types of restricted price promotions: threshold promotions (conditional on spending more than a threshold amount; e.g., “Get $5 off on orders of $10 or more”) and capped promotions (limited to a maximum dollar value; e.g., “Get 50% off, up to $5 per order”). Results from seven pre-registered studies, including one field study, show that threshold promotions lead to higher purchase intentions and conversion rates (but potentially lower purchase amounts) than comparable capped promotions—even though capped promotions are equivalent in maximal economic savings for the consumer—when the trigger value (the spending amount at …

Gaming The Marketplace: Consumer Opportunism And Beliefs About Societal Hierarchy, Shilpa Madan, Aparna Labroo, Constantine S. Katsikeas

Research Collection Lee Kong Chian School Of Business

Consumers often behave opportunistically, taking more than what fair marketplace exchange warrants (e.g., taking excess samples, returning used items). While each individual transgression may be minor, cumulatively they can undermine firm profitability. Thus, addressing consumer opportunism is an important managerial concern. We identify a novel antecedent of consumer opportunism: consumers’ acceptance of societal hierarchy (i.e., power distance belief [PDB]), including firms’ higher position in it than consumers. Nine studies (plus two supplementary studies) employing archival, correlational, and experimental data provide converging evidence that, in marketplace interactions, this belief evokes a need to feel clever (i.e., to feel smart and knowledgeable …

Lessons Learned From The Adrenalin Load Disaggregation Challenge, András Balázs Tolnai, Zheng Ma, Igor Sartori, Clayton Miller, Stephen White, Matt Amos, Gustaf Bengtsson, Akram Hameed, Nørregaard Bo Jørgensen

Research Collection College of Integrative Studies

Crowdsourced data science competitions have emerged as a powerful mechanism for advancing research in energy informatics, offering scalable pathways for developing machine learning solutions that enhance energy efficiency and smart building operations. The ADRENALIN Load Disaggregation Challenge addressed a central problem in energy analytics—non-intrusive load monitoring (NILM) of heating and cooling loads in commercial buildings—while emphasizing the importance of model generalization across different buildings. This paper presents a comprehensive reflection on the lessons learned from organizing and executing the ADRENALIN competition, including technical insights, organizational challenges, and recommendations for future energy data challenges. In addition to the ADRENALIN case, a …

Casual Killing In The Home: Ecological Citizenship And The Micro-Geopolitics Of Mosquito Cohabitation, Orlando Woods, Junxi Qian

Research Collection College of Integrative Studies

This article explores how the visceral acts of being bitten by and killing mosquitoes can underpin the formation of ecological citizenship. This form of citizenship is premised on human-nature entanglement and raises questions concerning how the rights and responsibilities stemming from such entanglement become distributed across the public and private domains. As a space in which mosquito cohabitation is contested daily, the home is a key site through which ecological citizenship can be forged and theoretical debates concerning urban political ecology can be extended. Human-mosquito entanglements in the home can reveal the limits of public pest management strategies, the partiality …

Sludge-To-Sod: Sustainability In Action At Bull Creek Water Treatment Plant, Ava Baker

Goal 6: Clean Water and Sanitation

No abstract provided.

Protecting Wetlands In Georgetown County, Sophia Harrison

Goal 6: Clean Water and Sanitation

No abstract provided.

From Personal To Personalized Goals: How Goal Nudges Improve Production, Joaquín Gómez-Miñambres, Brice Corgnet, Roberto Hernán González

ESI Working Papers

We study how workers’ non-binding self-set goals affect their production and whether goal nudges (ability-calibrated goal hints) make goal setting more effective. In a real-effort task, participants first complete an ability pretest and are then assigned to one of three treatments: a no-goal baseline, a personal goal treatment with no external hint, or a personalized goal nudge that participants may accept or modify. We document a positive link between goals and production. However, merely asking workers to set goals is ineffective: when left unguided, workers anchor on conservative goals well below those induced by goal nudges, leading to underperformance. In …

Friends Of The Library Newsletter, Summer/Fall 2026, Hillary Richardson

Fant Library News and Reports

No abstract provided.

Shared And Distinct Alterations In Brain Structure Of Youth With Internalizing Or Externalizing Disorders: Findings From The Enigma Antisocial Behavior, Adhd, Major Depressive Disorder, And Anxiety Working Groups, Sophie Townend, Marlene Staginnus, Yidian Gao, Nina Alexander, Volker Arolt, Tobias Banaschewski, Katja Beesdo-Baum, Mark A. Bellgrove, Vivek Benegal, Anderson M. Winkler

Human Genetics Publications

Background: Externalizing and internalizing disorders are common in youth but are often studied separately, preventing researchers from identifying shared (i.e., transdiagnostic) alterations in brain structure. Using data from the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium, we conducted a mega-analysis to identify shared and distinct cortical and subcortical brain alterations across internalizing (anxiety disorders and depression) and externalizing (attention-deficit/hyperactivity disorder [ADHD] and conduct disorder [CD]) disorders in youth.

Methods: 3D T1-weighted magnetic resonance imaging data from youths (age range 4-21 years) with anxiety disorders (n = 1044), depression (n = 504), ADHD (n = 1317), and CD (n = 1172) …

The Fall Of King Arthur Of Britain In Giovanni Boccaccio’S On The Downfall Of The Famous, Christopher Berard, Morris Tichenor

Humanities Program Faculty Publications

Giovanni Boccaccio (1313–75), born in Certaldo, Tuscany, is one of the tre corone (Three Crowns) of Italian Literature. He shares this distinction with Dante Alighieri (1265–1321), about whose life and literary works he wrote treatises and delivered lectures, and Francesco Petrarch (1304–74), with whom he formed a lasting friendship (beginning in 1350). All three wrote widely acclaimed literature in the Florentine-Tuscan dialect of Italian, enabling it to become the basis for standard Italian. In addition to elevating the Italian vernacular as a literary language, they prioritized Classical Studies and were forerunners of the Italian humanist movement (c.1400–1600). Today, Boccaccio is …

Visual Cues Attract Adult Tunga Penetrans (Siphonaptera: Tungidae), Ayako Hyuga, Paul Ouma, Lynne Elson, Kazuchiyo Miyamichi, Satoshi Kaneko, Kensuke Goto, Tullu Bukhari, Jürgen Krücken, Ulrike Fillinger

All Peer-Reviewed Publications

Tunga penetrans (Linnaeus, 1758) (Siphonaptera: Tungidae) is an ectoparasitic flea whose adult females cause tungiasis by embedding into the host’s skin. Environmental, social and financial challenges in tungiasis endemic areas have left this disease neglected and lacking locally available control measures. One possible approach for controlling T. penetrans targets its off-host stages; however, surveillance tools for adult fleas are still lacking. Moreover, host-seeking cues and behaviour of adult T. penetrans remain largely unknown. In this study, we show that visual cues are attractive to adult T. penetrans. Newly emerged T.penetrans responded to light stimuli across a broad spectrum, ranging from …

Dynamic Spectral Denoising With Global-Context Attention For Multi-Behavior Recommendation, Miaomiao Cai, Yunshan Ma, Fangqi Zhu, Junfeng Fang, Zhijie Zhang, Zhiyong Cheng, Xiang Wang, See-Kiong Ng

Research Collection School Of Computing and Information Systems

Multi-behavior recommendation improves target-behavior predic-tion by exploiting heterogeneous auxiliary feedback (e.g., view,collect, and cart), yet its robustness is often undermined by behavior-dependent noise and inconsistency. We argue that the key bottle-neck is not merely noisy behaviors, but a representation-level failurecaused by two coupled heterogeneities. First, intra-behavior rep-resentation entanglement arises when multi-hop propagationblends incidental signals with true preferences in the embeddingspace. This entanglement renders coarse spatial denoising inef-fective, since it cannot suppress noise without sacrificing weak-but-informative niche signals. Second, inter-behavior reliabilityheterogeneity complicates cross-behavior fusion, as the predic-tive value of auxiliary behaviors varies substantially across usersand contexts. Without reliability calibration, aggregation can …

Success Of New Ideas In Online Platforms: An Idea Network Perspective, Yimei Zhou, Qian Tang, Vincent Z.W. Mack Mack, Shao Yi Liaw

Research Collection School Of Computing and Information Systems

On online platforms, new ideas often emerge by recombining existing ones within idea networks. Unlike traditional knowledge networks, idea networks represent curated, meaning-based associations among ideas, offering a distinct lens on recombination. Drawing upon a hypergraph perspective, we investigate how new idea success depends on their structural and content attributes, and how collaborative participation shapes these attributes. Using data from an ideation platform, we find that both structural embeddedness and bridging benefit new idea success. Content diversity has no direct effect, but it amplifies the benefits of bridging while constraining those of embeddedness. Both crowd contributions and ideator expertise strengthen …

Definitions And Mathematical Models Of Op Variants, Pieter Vansteenwegen, Aldy Gunawan

Research Collection School Of Computing and Information Systems

We have described the basic orienteering problem (OP) in Chap. 2, as one known variant of the single vehicle routing problems with profits (VRPP). In this chapter, we introduce the best-known variants of the OP. The first one is the team orienteering problem (TOP). In the TOP multiple routes can be composed to visit a subset of customers. In the context of the game of orienteering, the TOP corresponds to several players of the same team, each collecting profits in parallel, during the same time span. Another well-known variant of the basic OP is the OP with time windows (OPTW), …

The Interplay Of Interdependence And Correlation In Bilateral Trade, Takashi Kunimoto, Cuiling Zhang

Research Collection School Of Economics

Following Crémer and McLean (1985, 1988) for finite type spaces and McAfee and Reny (1992) for continuous ones, we establish two respective sufficient conditions for the existence of efficient, ex ante budget-balanced mechanisms satisfying Bayesian incentive compatibility (BIC) and interim individual rationality (IIR) in bilateral trade settings with interdependent values and correlated beliefs. We then utilize the ex ante welfare (EAW) condition proposed by Kunimoto and Zhang (2026), which is necessary for the stricter requirement of ex post budget balance. We prove that while the EAW condition is sufficient in a two-type model and generalizes existing conditions in the literature, …

Singapore In Global Value Chains: Implications Of The Trump Ii Tariffs, Pao-Li Chang, Ruoqing Chen

Research Collection School Of Economics

This paper examines Singapore’s structural position in global value chains (GVCs) and the implications of the second Trump administration’s tariff escalation for Singapore and the broader ASEAN region. We proceed in three parts. First, using the ADB Multi-Regional Input–Output (MRIO) tables for 2019 and 2024, we characterise Singapore’s GVC participation and position. Singapore is the most GVCintensive economy in ASEAN, with nearly half of its gross exports comprising foreign value-added and a markedly downstream orientation. China is its dominant upstream partner across manufacturing and services—intermediating over 27% of foreign content in electronics and over 10% in chemicals—while Malaysia, Taiwan, and …

Marital Stability And Intrahousehold Inequality, Tomoki Fujii, Xirong Lin, Jacob Penglase

Research Collection School Of Economics

We study what predicts marital instability using a unique dataset from Japan with detailed measures of spouses’ consumption, savings, labor supply, satisfaction, and marriage-market conditions. We combine descriptive survival and event-study analyses with several econometric and machine-learning approaches, including Cox proportional-hazards models and DynForest, a method designed for survival data with time-varying covariates. Across these approaches, match quality, household resources, time use, stated satisfaction, and marriage-market conditions all contain predictive information. Our main contribution is to show that intrahousehold consumption allocation matters, highlighting information that is missed by standard demographic, time use, and income measures. We relate these findings to …

Advancing Health Equity In Global Oncology: A Collaborative Academic-Cancer Society-Industry Program To Address Health Disparities In Sub-Saharan Africa, Kenneth Merrell, Ben Kamdem-Talom, Hannah Anie, Christine Wekesa, Nomsa Tsikai, Miriam Mutebi, Rakiya Saidu, Nwamaka Lasebikan, Adamu Bojude, Randiak Alaro

General Surgery, East Africa

Purpose Cancer care capacity in sub-Saharan Africa (SSA) is constrained by late diagnosis and limited treatment access. Few funding mechanisms support innovative, locally led programs to address these challenges. A collaborative initiative was developed to strengthen oncology care through quality improvement (QI) projects.

Materials and Methods The program was developed by Global Bridges Oncology (GBO) at Mayo Clinic, Pfizer Global Medical Grants, and the African Organisation for Research and Training in Cancer. A committee composed primarily of African oncology experts guided the process. An RFP was disseminated across SSA in English, French, and Portuguese, inviting applications to improve diagnostic and …

Expanding Cleft Surgical Workforce Capacity In Low- And Middle-Income Countries Through Competency-Based Training, Daniel Bradley, Jonathan Diaz, Emily Jones, Kealani Unkel, Atenas Bustamante, Zenebe Gebremariyam, Daniel Abate, Mamy Andriamanarivo, Mekonen Abebe, Armando Siu

General Surgery, East Africa

Objective To evaluate a competency-based cleft surgery training pathway designed to expand local surgical capacity in low- and middle-income countries (LMICs).

Design Prospective observational study of cleft surgery training outcomes between July 2022 and September 2024.

Setting Operation Smile cleft surgery programs and partner hospitals in LMICs, with integrated virtual education.

Patients/Participants Twenty trainee cleft surgeons from 11 countries.

Interventions A competency-based training pathway combining virtual education and mentored operative experience, with assessment using a validated surgical competency tool.

Main Outcome Measures Changes in self-reported surgical confidence and educator-rated surgical competency

Results Trainee cleft surgeons participated in 1168 cleft lip …

Enhanced Communication Is Fundamental In Providing Quality Care, Jacqueline Turcotte Rn, Msn, Ccrn

MaineHealth Maine Medical Center

No abstract provided.

Engagement Of Understudied Populations As Community Change: The South Texas Adrc Model, Gladys E. Maestre, Neela K. Patel, Rosa V. Pirela, Robin C. Hilsabeck, Kendra Stine, Neyra García, Roberto Reyes, Omar Oropeza, Cristian Maestre, Jesus D. Melgarejo, Sarah Williams-Blangero, Ney Alliey Rodriguez

School of Medicine Publications

Many populations experiencing the highest burdens of Alzheimer's disease and related dementias remain understudied, in part because traditional recruitment and retention models are insufficient to support sustained engagement. The Outreach, Recruitment, and Engagement Core (OREC) of the South Texas Alzheimer's Disease Research Center reconceptualized participant recruitment as a long-term system change in a Hispanic-majority, urban–rural region. OREC institutionalizes shared power through community advisory governance, aligns research protocols with local lived realities (through patient navigators, community health workers/promotores, and decentralized access points), and employs a data-driven feedback loop for continuous improvement. In 1 year, 46 outreach events touched 10,134 individuals (71% …

End Matter

AWE (A Woman’s Experience)

No abstract provided.

It Is Literally Impossible To Be A Monologue: The Misplaced Generalizations Of Barbie, Mabel Court

AWE (A Woman’s Experience)

The summer of 2023 was a hot pink pressure cooker that transformed the Barbie brand from a dusty relic into an omnipresent cultural phenomenon. The Barbie movie’s savvy marketing team colored billboards bright fuschia, with the film’s mystery-shrouded plot fueling a thunderous roar of speculative chatter that crescendoed until its long-anticipated release. A star-studded cast and auteur director Greta Gerwig were the cherries on top, rocketing the film to critical and economic success. The film was heralded as thematically ambitious, one of the best comedies in recent memory, and a “feminist self-aware masterpiece” (Barbie Movie Reviews). Although Barbie marked a …

Jael The Kenite, Madison Sacriste

AWE (A Woman’s Experience)

No abstract provided.

The First Thirteen Years, Crystal Gonzalez Callison

AWE (A Woman’s Experience)

No abstract provided.

Full Issue

Comparative Civilizations Review

No abstract provided.

Race-Associated Egfr And Kras Mutation Profiles In Lung Adenocarcinoma, Lovyanne Vergel De Dios, Catherine Wu, Salique Hassan Shaham, Manish K. Tripathi

School of Medicine Publications

Background: Lung adenocarcinoma (LUAD) is the most prevalent histologic subtype of non-small cell lung cancer (NSCLC) and exhibits considerable molecular heterogeneity. Among the most clinically significant driver alterations are mutations in EGFR and KRAS, both of which influence treatment selection and oncologic outcomes. The prevalence of these mutations varies by race, yet racial minority populations remain underrepresented in genomic studies. EGFR alterations are more frequently observed in Asian patients, while KRAS mutations predominate in non-Asian cohorts. This study aimed to characterize race-associated differences in driver mutation prevalence among Asian, Black, and White patients with LUAD. Methods: A retrospective secondary cohort …

Digital Commons Statistics For August 2026, Liberty University

Digital Commons Statistics

No abstract provided.

Defining The Value Of Elective Lumbar Fusion: A Systematic Review Of Existing Methodologies And Framework For The Operative Value Index, Advith Sarikonda, Anthony Chen, Theo S. Biddle, Danyal A. Quraishi, Preston Carey, Arbaz A. Momin, Matthews Lan, Dwight Mitchell Self, Ashmal S. Kabani, Ahilan Sivaganesan

Department of Neurosurgery Faculty Papers

BACKGROUND: Despite wide variation in the outcomes and costs of lumbar fusion, few studies have integrated these domains together within a single metric to assess "value" (outcomes achieved per dollar spent). In this review, we sought to 1) characterize existing metrics of cost-effectiveness for lumbar fusion, 2) evaluate all applications of time-driven activity-based costing (TDABC) in spine surgery, and 3) outline the conceptual foundation for a standardized Operative Value Index (OVI).

METHODS: Two PRISMA-concordant systematic reviews were performed on PubMed and Scopus databases. The first review examined all studies which reported a cost-effectiveness metric for lumbar fusion. The second review …