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Articles 107911 - 107940 of 5150687
Full-Text Articles in Entire DC Network
Towards Spatial Inversion Of Aerial Gamma-Ray Survey Data For Measurement Of Naturally Occurring Radioactivity, Daniel A. Haber
Towards Spatial Inversion Of Aerial Gamma-Ray Survey Data For Measurement Of Naturally Occurring Radioactivity, Daniel A. Haber
UNLV Theses, Dissertations, Professional Papers, and Capstones
Aerial gamma-ray surveying (AGRS) is used in geologic and environmental contexts to provide data on the surface spatial distribution of naturally occurring radioactive material (NORM) or other gamma-ray-emitting isotopes. The standard data reduction workflow for AGRS data involves a process whereby pointwise gamma-ray spectral data are denoised, corrected for numerous sources of background radiation and aircraft height, and are finally converted to physical values by empirical conversion factors. The reduced pointwise data are then typically spatially interpolated to form a continuous surface map.
This dissertation introduces and explores a novel spatial inversion method for reduced AGRS data that considers aircraft …
Applying Instrumental Neutron Activation Analysis (Inaa) To Characterize Trace Elements In Water Samples Around Lake Mead, Danesha Hunter
Applying Instrumental Neutron Activation Analysis (Inaa) To Characterize Trace Elements In Water Samples Around Lake Mead, Danesha Hunter
UNLV Theses, Dissertations, Professional Papers, and Capstones
Lake Mead, the largest reservoir in the United States is located on the boarder of Nevada and Arizona. Despite reaching historically low water levels, it continues to supply water and energy to millions of Americans in the southwest. It is well known that the United States suffers from negative implications from nationwide drought. The ongoing megadrought affecting the Colorado River Basin and its tributaries undergoes the urgent need to assess the future water quality of Lake Mead as it continues to shrink. With water levels depleting at an alarming rate, water quality is significantly impacted, indicating that heavy metal accumulation …
Post-Probationary Principals’ Perceptions Of Professional Development, Matthew Jackson
Post-Probationary Principals’ Perceptions Of Professional Development, Matthew Jackson
UNLV Theses, Dissertations, Professional Papers, and Capstones
This qualitative phenomenological study explored post-probationary principals’ perceptions of professional development, examining the relevance, adequacy, and impact of support provided after 4 years of their leadership. Although research and policy have emphasized the development of new principals, professional learning opportunities for those beyond probationary status remain inconsistent, generic, and misaligned with individual and contextual needs. Guided by adult learning theory, this study sought to understand how post-probationary principals evaluate current professional development, describe their desired opportunities, and determine their ongoing needs. Data were collected through semi-structured interviews with principals from multiple districts and analyzed using coding, memo writing, and mind …
Overcoming The Labor Shortage: Enhancing Pga Associate Education Through Targeted Support, Brian Milford Jones
Overcoming The Labor Shortage: Enhancing Pga Associate Education Through Targeted Support, Brian Milford Jones
UNLV Theses, Dissertations, Professional Papers, and Capstones
The golf industry faces a critical workforce shortage, exacerbated by impending retirements and a lack of new PGA Members. This exploratory sequential, mixed-method study investigates the barriers and facilitators PGA Associates encounter during their education and identifies support strategies to enhance completion rates. Employing both qualitative and quantitative approaches, the research explores barriers, completion metrics, facilitator impact, and perceived support benefits. Qualitative data from interviews with Section Executive Directors who oversee PGA Associate development, analyzed through thematic coding, informs the survey instrument. Quantitative data, collected via surveys with PGA Associates themselves, was analyzed using confirmatory factor analysis (CFA) and structural …
Face Recognition Ability: The Role Of Facial Experience Across The Lifespan, Kirsty Kulhanek
Face Recognition Ability: The Role Of Facial Experience Across The Lifespan, Kirsty Kulhanek
UNLV Theses, Dissertations, Professional Papers, and Capstones
The other-race effect is a phenomenon in which individuals are better able to recognize individuals of their own race than individuals of another race. These effects begin to develop during the first year of life and may be attenuated by intergroup contact. Limited research in the language domain has suggested that multilingualism may result in easier learning of non-native speech contrasts, so it is of interest whether early experience with racially diverse faces may result in more easily learning to recognize unfamiliar race faces. We conducted two studies to examine the effects of early diverse experience with faces on recognition …
The Impact Of Formally Trained Teacher Leaders On Student Outcomes, Jodi Notch
The Impact Of Formally Trained Teacher Leaders On Student Outcomes, Jodi Notch
UNLV Theses, Dissertations, Professional Papers, and Capstones
This study examined the relationship between teacher leadership and student achievement through the lens of Distributed Leadership Theory. Specifically, it addresses three research questions: (a) To what extent is the implementation of teacher leadership by formally trained teacher leaders associated with academic success in schools? (b) Is there a difference in impact between formal teacher leader positions versus informal teacher leader positions? (c) How does having multiple teacher leaders in a school impact student outcomes? Using a two-way fixed effects design with a longitudinal panel data set, the analysis investigates the effects of employing teacher leaders trained through a formal …
Integrating Post-Quantum Cryptography Into A Cdn-Style Pki: Tls And Quic Performance Across Pqc Suites, Katrina Mary Parsom
Integrating Post-Quantum Cryptography Into A Cdn-Style Pki: Tls And Quic Performance Across Pqc Suites, Katrina Mary Parsom
UNLV Theses, Dissertations, Professional Papers, and Capstones
Post-quantum cryptography (PQC) adds larger certificates and extra workload to the Transport Layer Security (TLS) handshake. In order to analyze the effect of that change on content delivery, a controlled testbed with conditions replicating a Content Delivery Network (CDN) is used. The system uses a standard X.509 certificate chain over TLS 1.3. It compares RSA with classical key exchange, RSA with hybrid key encapsulation mechanism (KEM), and Module Lattice-based Digital Signature Algorithm (ML-DSA) with hybrid KEM. The test harness generates and provides certificates and establishes TLS parameters. The test harness also supports mixed web workloads and records key metrics, including …
Ankimedbench: Evaluating Hierarchical Medical Knowledge In Language Model Embeddings, Neel Patel
Ankimedbench: Evaluating Hierarchical Medical Knowledge In Language Model Embeddings, Neel Patel
UNLV Theses, Dissertations, Professional Papers, and Capstones
Despite achieving over 90% accuracy on medical benchmarks, recent studies show physicians cannot effectively leverage language models to improve clinical reasoning. Current benchmarks test isolated factual recall, but clinical practice requires hierarchical navigation through diagnostic categories—starting broad and narrowing systematically from chest pain to cardiovascular pathology to myocardial infarction to specific STEMI types. Existing evaluations cannot measure whether models preserve this taxonomic structure essential for clinical reasoning.
We introduce AnkiMedBench, built from 16,512 medical flashcards used by students preparing for licensing exams. Cards are organized across six hierarchy levels spanning 16 broad medical specialties to 672 specific diseases and conditions. …
Demographic Similarity, Psychopathy, And Perceived Inherent Value: An Investigation Of Factors Influencing Moral Decision Making, Ashley Michelle Poston
Demographic Similarity, Psychopathy, And Perceived Inherent Value: An Investigation Of Factors Influencing Moral Decision Making, Ashley Michelle Poston
UNLV Theses, Dissertations, Professional Papers, and Capstones
The present study experimentally manipulated the demographic characteristics of the subjects of moral dilemmas such that they were 20%, 40%, 60%, and 80% demographically similar to participants. Participants rated each of these individuals on a novel measure of perceived inherent value, the Perceived Inherent Value Scale (PIVS) and responded to a series of moral dilemmas using the Consequences, Norms, and preference for Inaction (CNI) model of moral decision making where the subjects of the moral dilemmas were the 20%, 40%, 60%, and 80% similar individuals. Participants rated individuals who were more demographically similar to themselves as having greater perceived inherent …
Perceptions And Behaviors Of Female Title I Principals And Faculty Trust In The Post-Covid-19 Educational Environment, Jessica A. Robbins
Perceptions And Behaviors Of Female Title I Principals And Faculty Trust In The Post-Covid-19 Educational Environment, Jessica A. Robbins
UNLV Theses, Dissertations, Professional Papers, and Capstones
Faculty trust in principals is essential to a healthy school culture, yet it remains one of the most fragile and complex aspects of leadership, particularly in Title I schools (Tschannen-Moran, 2007, 2014; Tschannen-Moran et al., 2015). While trust has been widely studied, fewer investigations have focused on the specific behaviors female principals use to build trust in the post-COVID era (Berkovich, 2018; Bukko et al., 2021; Handford & Leithwood, 2013; Jeanquart-Barone, 2013; Zajda et al., 2023; Zheng et al., 2021). Research suggests that women in leadership must be deliberate in fostering trust, yet their behaviors are often judged more harshly …
“I Can Gossip With Anybody, I Can’T Chisme With Everybody”: Chisme, Gossip, And Identity In Latina-Americans, Alexa B. Romero
“I Can Gossip With Anybody, I Can’T Chisme With Everybody”: Chisme, Gossip, And Identity In Latina-Americans, Alexa B. Romero
UNLV Theses, Dissertations, Professional Papers, and Capstones
As individuals adjust to their belonging to two distinct cultures, there are various ways of adapting to their navigation of the two cultures (Berry, 1980). The way(s) an individual chooses to adjust to their two cultures can have varying effects on identity. When directly translated, chisme (Spanish) means gossip. Although the two include overlap in function and uses, chisme offers unique purposes for the Latinx community and further, Latina-Americans (González Ybarra & Player 2024; Gutierrez, 2017; Uribe, 2025). By using the communication theory of identity (Hecht, 1993) the purpose of this thesis was to investigate the role of chisme and …
Ultrafast Dynamics Of Two-Dimensional Electron Systems, Randy Michael Sterbentz
Ultrafast Dynamics Of Two-Dimensional Electron Systems, Randy Michael Sterbentz
UNLV Theses, Dissertations, Professional Papers, and Capstones
On-chip terahertz time-domain spectroscopy (THz-TDS) is a technique useful for measuring the ultrafast electrodynamics of two-dimensional (2D) electronic systems. Charge carrier collisions occur on the sub-picosecond time scale, and strongly correlated electron interactions (such as superconductivity) typically have energies on the order of milli-electron-volts. These phenomena fall within the terahertz bandwidth, which has historically been difficult to access. Commercial electronics operate with transistors capable of switching rates of around 100 GHz, while small band gap semiconductors (like InGaAs) can detect light down to 0.75 eV (180 THz). When combined with the difficulty of measuring 2D layered materials, with lateral sizes …
Quantum Sensing Of Magnetic And Thermal Fields Using Nitrogen-Vacancy Centers On Spoof Surface Plasmon Waveguides, Maxwell Stonham
Quantum Sensing Of Magnetic And Thermal Fields Using Nitrogen-Vacancy Centers On Spoof Surface Plasmon Waveguides, Maxwell Stonham
UNLV Theses, Dissertations, Professional Papers, and Capstones
Nitrogen-vacancy (NV) centers in nanodiamonds are solid-state quantum defects capable of detecting magnetic fields and temperature at the nanoscale with high spatial resolution and optical addressability at room temperature. Their spin-dependent fluorescence enables optically detected magnetic resonance (ODMR), a technique widely used for quantum sensing. However, enhancing optical readout efficiency remains a critical challenge for scalable integration and various methods can be used to improve this.
This thesis explores a hybrid quantum sensing platform that integrates NV-based sensing with spoof surface plasmon waveguides designed to enhance optical excitation and emission efficiency through localized spoof plasmon modes supported by subwavelength corrugated …
Integrating Classical Singing Techniques To Aid Natives In Performing Traditional Tongan Folk Songs Of The Late Queen Sālote Tupou Iii, Pauline 'Ofa Vaitāfā Tamale
Integrating Classical Singing Techniques To Aid Natives In Performing Traditional Tongan Folk Songs Of The Late Queen Sālote Tupou Iii, Pauline 'Ofa Vaitāfā Tamale
UNLV Theses, Dissertations, Professional Papers, and Capstones
This document introduces a structured, classical vocal approach to equip native singers with healthier performance techniques and enable anyone in the music world to perform the art songs derived from the poetry and compositions of Queen Sālote Tupou III. The objective of this project is to provide performers, particularly those with a native proficiency, with classical techniques to perform this music with vigor while circumventing vocal fatigue caused by the linguistic, dialectal, and cultural demands inherent in the repertoire. Queen Sālote Tupou III (1900–1965) reigned for nearly 50 years – the longest of any Tongan monarch – and left an …
Deaf College Students’ Lived Experiences In Pk-16 Education: A Deaf Crit-Informed Qualitative Study, Bridget Catherine Taylor
Deaf College Students’ Lived Experiences In Pk-16 Education: A Deaf Crit-Informed Qualitative Study, Bridget Catherine Taylor
UNLV Theses, Dissertations, Professional Papers, and Capstones
This qualitative study focused on Deaf, Hard-of-Hearing, and orally Deaf college students, examining Deaf education from the perspective of linguistic and cultural minority students. The study offers theoretical perspectives for researchers, practitioners, and policymakers by examining the lived experiences of students who took part in Deaf education in the United States from PK–16. Deaf Critical Theory (DeafCrit) was the theoretical framework used to analyze the qualitative data.
The Effectiveness Of Storytelling As A Sleep Aid For Children With Adhd And Sleep Difficulties, Boonchitchaya Chamnanphai, Tippawan Hansakunachai, Issarapa Chunsuwan
The Effectiveness Of Storytelling As A Sleep Aid For Children With Adhd And Sleep Difficulties, Boonchitchaya Chamnanphai, Tippawan Hansakunachai, Issarapa Chunsuwan
Asian Medical Journal and Alternative Medicine
Introduction: Sleep-related problems among children with attention deficit hyperactivity disorder (ADHD) is common. Behavioral interventions are the first-line treatment for sleep problems in children with ADHD. Meditation has gained interest as an alternative treatment for sleep problems.
Objectives: To determine whether a sleep intervention could reduce sleep problems, improve ADHD symptoms and enhance parental mental health.
Methods: A randomized controlled trial (RCT) of 52 children (4–12 years) with ADHD and sleep problems was undertaken. The 2 week intervention covered sleep hygiene, daily Line messages and meditation stories. The control group received sleep hygiene and usual care. Outcomes were measured using …
Gpu-Accelerated Effective Hamiltonian Calculator, Abhishek Chakraborty, Taylor L. Patti, Brucek Khailany, Andrew N. Jordan, Anima Anandkumar
Gpu-Accelerated Effective Hamiltonian Calculator, Abhishek Chakraborty, Taylor L. Patti, Brucek Khailany, Andrew N. Jordan, Anima Anandkumar
Mathematics, Physics, and Computer Science Faculty Articles and Research
Effective Hamiltonian calculations for large quantum systems can be both analytically intractable and numerically expensive using standard techniques. In this manuscript, we present numerical techniques inspired by Nonperturbative Analytical Diagonalization (NPAD) and the Magnus expansion for the efficient calculation of effective Hamiltonians. While these tools are appropriate for a wide array of applications, we here demonstrate their utility for models that can be realized in circuit-QED settings. Our numerical techniques are available as an opensource Python package, qCHeff, which is available on GitHub (https://github.com/ NVlabs/qCHeff) and PyPI (https://pypi.org/ project/qcheff/). We use the CuPy library for GPU-acceleration …
Diagnostic Stewardship Considerations In Infectious Diseases, Shawn Vasoo
Diagnostic Stewardship Considerations In Infectious Diseases, Shawn Vasoo
Asian Medical Journal and Alternative Medicine
Diagnostic stewardship in infectious diseases is crucial to ensure that the right test is performed for the right patient for the right reasons at the right time, with the right interpretation which results in the right treatment, optimizing patient care. Managing clinicians have a critical role to play in thoughtful decision making in the pre- and post-analytic phases of test selection, interpretation and subsequent action. They also need to have a good understanding of the analytic phase of testing (test performance characteristics and limitations). In this paper, diagnostic stewardship across the main testing modalities for infectious diseases (culture, serology and …
Replacement And Reputation, Navin Kartik, Elliot Lipnowski, Harry Pei
Replacement And Reputation, Navin Kartik, Elliot Lipnowski, Harry Pei
Cowles Foundation Discussion Papers
Does electoral replacement ensure that officeholders eventually act in voters’ interests? We study a reputational model of accountability. Voters observe incumbents’ performance and decide whether to replace them. Politicians may be “good” types who always exert effort or opportunists who may shirk. We find that good long-run outcomes are always attainable, though the mechanism and its robustness depend on economic conditions. In environments conducive to incentive provision, some equilibria feature sustained effort, yet others exhibit some long-run shirking. In the complementary case, opportunists are never fully disciplined, but selection dominates: every equilibrium eventually settles on a good politician, yielding permanent …
Applied Research For Corn Production In Indiana, 2023, Daniel Quinn
Applied Research For Corn Production In Indiana, 2023, Daniel Quinn
Purdue University Press Books
The 2023 edition of Applied Research for Corn Production in Indiana offers accessible, research-based tips for farmers who want to improve corn production practices by using applied field-research trials. Daniel Quinn and the Purdue University Corn Agronomy team reveal practical ways to boost yields, reduce costs, and improve sustainability on the farm. Their findings are derived from applied research trials across the state and relate to important topics such as planting practices, fertilizer use, crop nutrition, cover crops, and new technologies. Applied Research for Corn Production in Indiana distills complex research into clear insights and supplies corn producers with effective …
Violence Between Residents In Nursing Homes Is An Enduring Problem. The Agencies, Nursing Homes, And Residents Are Playing Hot Potato With The Responsibility, Cindy Marchionda, Rafael Escalara Montoto
Violence Between Residents In Nursing Homes Is An Enduring Problem. The Agencies, Nursing Homes, And Residents Are Playing Hot Potato With The Responsibility, Cindy Marchionda, Rafael Escalara Montoto
Capstones
Resident-to-resident aggression in nursing homes is a persistent issue, far more common than the general public realizes. While many of these violent situations can be managed, some tragically escalate to fatal outcomes, leaving families mourning the loss of their loved ones at the hands of a facility that was meant to provide safety and care during their final years. Experts agree that this issue is largely driven by chronic understaffing and insufficient training for employees on how to manage patients with dementia and aggression issues.
How Climate For Green Initiatives Drives Eco-Innovative And Citizenship Behaviours: The Role Of Green Engagement And Green Values, Aaron Makafui Ametorwo, Michael Kyei-Frimpong, Abdul Razak Suleman
How Climate For Green Initiatives Drives Eco-Innovative And Citizenship Behaviours: The Role Of Green Engagement And Green Values, Aaron Makafui Ametorwo, Michael Kyei-Frimpong, Abdul Razak Suleman
Research outputs 2022 to 2026
Purpose This study proposes and tests the nexus between climate for green initiatives, green innovative behaviour, organisational citizenship behaviour for the environment, green work engagement, and individual green values. Design/methodology/approach The study adopted the explanatory research design, where data were gathered from 374 star-rated frontline employees at two different waves within a one-month interval. The data retrieved from the respondents were analysed using descriptive and inferential (partial least squares structural equation modelling) statistics. Findings The study revealed that a climate for green initiatives positively and significantly relates to green innovative behaviour and organisational citizenship behaviour for the environment. Also, the …
Gender Equality Discourse: A Japanese Context, Gabriel Eweje, Hitomi Toyosaki, Kazunori Kobayashi, Sitong Michelle Chen, Masahiro Hosoda
Gender Equality Discourse: A Japanese Context, Gabriel Eweje, Hitomi Toyosaki, Kazunori Kobayashi, Sitong Michelle Chen, Masahiro Hosoda
Research outputs 2022 to 2026
Purpose – This review paper aims to critically examine the discourse on gender equality in Japan, focusing on its socio-cultural, economic and political dimensions. By synthesising existing literature, it provides a comprehensive understanding of the complexities and barriers that influence the gender equality debate in Japan, while identifying gaps and opportunities for future research and specifying where practice can be recoupled to policy. Design/methodology/approach – An integrative literature review was conducted across four key institutional domains – markets, government/public sector, families and education – analysed at the macro, meso and micro levels. The synthesis is integrative rather than exhaustive, prioritising …
Opening Brief For Plaintiff-Appellant Emery Barron, Steven Mitchell, Carolyn Sacco, Shaina Sikka, Madeline H. Meth
Opening Brief For Plaintiff-Appellant Emery Barron, Steven Mitchell, Carolyn Sacco, Shaina Sikka, Madeline H. Meth
Faculty Scholarship
By the time Emery Barron sued Pennsylvania Department of Corrections officials in 2021, they had kept him caged for almost six years in solitary confinement without providing a pathway for him to reenter general population. Department of Correction policy calls for officials to review the ongoing need for solitary confinement after an initial ninety-day stint in disciplinary confinement. However, procedural carve outs allow officials to leave people like Barron in solitary indefinitely without an opportunity to be heard by a decisionmaker and without requiring officials to assert any legitimate penological interest behind the confinement.
Under this scheme, which violated both …
Breaking Barriers: Understanding Factors Constraining Women’S Career Choices And Progression In The South African Construction Industry, Abimbola Olukemi Windapo, Olugbenga Timo Oladinrin, João Alencastro, Dineo Mbekwa, Christiana Ekpo, Muhammad Qasim Rana, Amanda Filtane
Breaking Barriers: Understanding Factors Constraining Women’S Career Choices And Progression In The South African Construction Industry, Abimbola Olukemi Windapo, Olugbenga Timo Oladinrin, João Alencastro, Dineo Mbekwa, Christiana Ekpo, Muhammad Qasim Rana, Amanda Filtane
School of Art, Design and Architecture
Purpose – This paper examines the barriers constraining women's career choices and progression within the South African construction industry. Design/methodology/approach – The study employed a mixed-methods research approach, utilizing a questionnaire survey of construction industry workers listed in the Construction Professions Register, the Builders Collective and the Housing Assembly Organization. It also used interviews to validate the quantitative data. The data collected were analysed using descriptive and inferential statistics, including factor analysis. Findings – The study found that 39 of the 46 barriers identified have normalized values greater than 0.5 and, therefore, are classified as critical. From a ranking perspective, …
Opinions Of The Uk General Public And Stroke Survivors In Using Artificial Intelligence And ‘Opt-Out’ Models Of Consent In Medical Research: A Qualitative Study, William Heseltine-Carp, Mark Thurston, Michael Allen, Daniel Browning, Megan Courtman, Aishwarya Kasabe, Emmanuel Ifeachor, Stephen Mullin
Opinions Of The Uk General Public And Stroke Survivors In Using Artificial Intelligence And ‘Opt-Out’ Models Of Consent In Medical Research: A Qualitative Study, William Heseltine-Carp, Mark Thurston, Michael Allen, Daniel Browning, Megan Courtman, Aishwarya Kasabe, Emmanuel Ifeachor, Stephen Mullin
Peninsula Medical School
Background Artificial intelligence (AI) in healthcare often requires large, confidential clinical datasets. However, a recent UK government survey revealed that 20–40% of the public remain sceptical of its use in health research due to concerns about data security, patient–practitioner communication and commercialisation of data. A greater understanding of public attitudes is therefore needed, particularly in the context of stroke research.In this article, we describe the patient and public involvement work undertaken for the AI-Based-Stroke-Risk-fActor-Classification-and-Treatment (ABSTRACT) project, which aims to train AI models to predict future stroke risk from the electronic health records of 1 18 736 patients.Aims We aimed to …
Spinach (Spinacia Oleracea L) Flavonoids Are Hydrolyzed During Digestion And Their Bioaccessibility Is Under Stronger Genetic Control Than Raw Material Content, Michael P Dzakovich, Alvin L Tak, Elaine A Le, Rachel P Dang, Benjamin W Redan, Geoffrey A Dubrow
Spinach (Spinacia Oleracea L) Flavonoids Are Hydrolyzed During Digestion And Their Bioaccessibility Is Under Stronger Genetic Control Than Raw Material Content, Michael P Dzakovich, Alvin L Tak, Elaine A Le, Rachel P Dang, Benjamin W Redan, Geoffrey A Dubrow
Children’s Nutrition Research Center Staff Publications
Spinach (
Structural Basis For Genome-Wide Site-Specific Dna Recognition By Nuclear Factor Ia, Ci Zhu, Ding Xiao, Zhipu Luo, Jie Zhang, Shuang Liu, Yueyu Wang, Xi Chen, Hejin Xiao, Xiaofeng Li, Juyu Tang, Xianyang Fang, Jie Shen, He Song
Structural Basis For Genome-Wide Site-Specific Dna Recognition By Nuclear Factor Ia, Ci Zhu, Ding Xiao, Zhipu Luo, Jie Zhang, Shuang Liu, Yueyu Wang, Xi Chen, Hejin Xiao, Xiaofeng Li, Juyu Tang, Xianyang Fang, Jie Shen, He Song
2020-Current year OA Pubs
Nuclear Factor IA, a member of the long-studied Nuclear Factor I family of DNA-binding proteins, plays pivotal roles in development and metabolism. Dysregulation or loss of Nuclear Factor IA is associated with severe neurological defects in humans and disruptions in fatty acid metabolism linked to conditions such as osteoarthritis. Despite extensive study, the DNA recognition mechanism of Nuclear Factor I family proteins remains unresolved. Previous studies have proposed that these proteins dimerize via their DNA-binding domains to bind TGGCA-containing dyad sequences. In this study, we demonstrate that both full-length Nuclear Factor IA and its isolated DNA-binding domain are monomeric in …
Methylation-Based Signature To Distinguish Indolent And Aggressive Prostate Cancer, Muheng Liao, Jace Webster, Amy Ly, Emily Rozycki, Christopher A Maher
Methylation-Based Signature To Distinguish Indolent And Aggressive Prostate Cancer, Muheng Liao, Jace Webster, Amy Ly, Emily Rozycki, Christopher A Maher
2020-Current year OA Pubs
Prostate cancer management faces significant challenges in distinguishing indolent from aggressive disease, particularly since most patients are intermediate-risk and therefore hinders the ability to recommend standardized treatment recommendations. Moreover, current prognostic tools including Gleason scoring and tumor staging demonstrate limited accuracy for predicting disease progression and tumor recurrence. DNA methylation serves as a stable epigenetic modification that directly regulates gene expression, making it an ideal biomarker for cancer prognosis. Therefore, this study leveraged whole-genome enzymatic methylation sequencing on 120 patients to develop a novel prognostic signature for aggressive prostate cancer progression. We analyzed 20,849 differentially methylated regions (DMRs) and employed …
The Double Patenting Puzzle, Michael Risch
The Double Patenting Puzzle, Michael Risch
Faculty Publications
It’s a simple rule: one patent per invention. This is easy to enforce when patent claims in two patents are identical, but what if the second patent claims something close but not quite the same? For more than 150 years, courts have held that obvious improvements over the prior art cannot be patented. But when inventors seek a small improvement in their own follow-on patents, there may not be any prior art because the law does not typically count inventors’ work against themselves. Inventors can include two similar claims in the same patent without objection, but if they split them …