Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 107221 - 107250 of 5154692

Full-Text Articles in Entire DC Network

April 4, 1968: A Law Student’S Night In The Memphis Jail, Alex Jay Hurder Dec 2025

April 4, 1968: A Law Student’S Night In The Memphis Jail, Alex Jay Hurder

Vanderbilt Social Justice Reporter

No abstract provided.


Science Meets Shoreline, Unh Communications And Public Affairs Dec 2025

Science Meets Shoreline, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.


Large Language Model Utilization For Speech-Based Culinary Recommendation System In The Indonesian Language, Mohammad Mauludin, Joan Santoso, Hartarto Junaedi Dec 2025

Large Language Model Utilization For Speech-Based Culinary Recommendation System In The Indonesian Language, Mohammad Mauludin, Joan Santoso, Hartarto Junaedi

Bulletin of Culinary Art and Hospitality

This study presents the development of a conversational culinary recommendation system in Indonesian using a Large Language Model (LLM). The system aims to generate personalized restaurant recommendations through natural language interaction while addressing the limited availability of Indonesian language conversational recommender systems. Data were collected from the online platform and enhanced with synthetic conversational data to train the model’s dialogue understanding and reasoning capabilities. The proposed architecture consists of four main components: Input/Output, Recommender Agent, Tools, and Memory, which collaborate to process user input, retrieve relevant restaurant information, and generate contextually appropriate responses. The Mistral 7B model was fine-tuned using …


Lithium–Sulfur Batteries: 3d Printed Tools And Assembly Techniques For Repeatable Lab-Scale Coin Cell Manufacturing, Daryl Miranda, Tosif Aliyev, Lamija Kovacevic, Sivapriya Voleti, Jaydie Lee, Kathleen Meehan, Monica C. So, Philip T. Dirlam Dec 2025

Lithium–Sulfur Batteries: 3d Printed Tools And Assembly Techniques For Repeatable Lab-Scale Coin Cell Manufacturing, Daryl Miranda, Tosif Aliyev, Lamija Kovacevic, Sivapriya Voleti, Jaydie Lee, Kathleen Meehan, Monica C. So, Philip T. Dirlam

Faculty Research, Scholarly, and Creative Activity

The coin cell form factor has become a standard in energy storage research owing to its relatively low cost, low quantity of requisite electroactive material, fast experimental turnover, and capability to generate publishable quality data. Coin cell assembly at the lab-scale requires precise manual alignment of the many internal components of a cell to yield a properly functioning device. Truly repeatable device assembly presents a significant challenge to the acquisition of reliable data. In this report, we present a three-dimensional (3D) printable design for a coin cell alignment device and describe techniques for a generalized workflow to achieve reproducible coin …


A Matrix-Independent Method For Direct Nanomolar Dissolved Aluminium Analysis In Seawater Using Programmable Flow Injection (Pfi), Maxime M. Grand, Mariko Hatta Dec 2025

A Matrix-Independent Method For Direct Nanomolar Dissolved Aluminium Analysis In Seawater Using Programmable Flow Injection (Pfi), Maxime M. Grand, Mariko Hatta

Faculty Research, Scholarly, and Creative Activity

Existing shipboard methods for dissolved Aluminium (Al) analysis in seawater require complex instrumentation, highly trained analysts, and calibration with ultra-clean seawater standards to achieve sub-nanomolar sensitivity at sea. To address these challenges, we developed a compact, user-friendly, and low-maintenance method for the determination of dissolved Al in seawater based on programmable Flow Injection (pFI) and the lumogallion fluorescence assay. We optimized reaction conditions and the pFI mixing protocol to minimize matrix effects, enabling accurate quantification of seawater samples using standards prepared in ultrapure water. The resulting Brij-enhanced fluorometric method yields a detection limit of 0.5 nM and '3 % precision …


Book Review: Pivotal Poland: Europe’S Rising Power, Magnus Petersson Dec 2025

Book Review: Pivotal Poland: Europe’S Rising Power, Magnus Petersson

Parameters Bookshelf – Online Book Reviews

Author: Janusz Bugajski

Reviewed by: Magnus Petersson, professor of international relations, Stockholm University

In the wake of Russia’s invasion of Ukraine, Poland has emerged as the strategic anchor of NATO’s eastern flank, reshaping the continent’s security landscape. Janusz Bugajski explores how Warsaw’s military modernization, economic resilience, and assertive diplomacy have positioned it as a rising power capable of countering Russian imperialism and leading regional defense efforts. This timely and incisive book reveals Poland’s transformation from a peripheral actor to a pivotal force in Europe’s evolving geopolitical order.

©2025 Magnus Petersson


Book Review: Sir Basil Liddell Hart: Life, Thought, Legacy, Kevin Mcaleer Dec 2025

Book Review: Sir Basil Liddell Hart: Life, Thought, Legacy, Kevin Mcaleer

Parameters Bookshelf – Online Book Reviews

Author: Bruce Oliver Newsome

Reviewed by: Kevin McAleer

Bruce Oliver Newsome’s book examines the life of Sir Basil Liddell Hart, and his claim to have invented the Blitzkrieg style of war used by the Germans during World War II. Newsome provides evidence that disputes this claim, which the reviewer commends for its thoroughness and nuanced point of view.

©2025 Kevin McAleer


Presidential Search Committee Minutes, Clemson University Board Of Trustees, 2025 December 18, Clemson University Board Of Trustees Dec 2025

Presidential Search Committee Minutes, Clemson University Board Of Trustees, 2025 December 18, Clemson University Board Of Trustees

Minutes

No abstract provided.


Shaping Oman’S Child Health Future By 2040: Key Projections For Population And Workforce In Developmental-Behavioural Paediatrics, Watfa Al-Mamari, Ahmed B. Idris, Rola Al-Balushi, Kamila Al-Alawi, Saquib Jalees, Ahmed Al-Saidi Dec 2025

Shaping Oman’S Child Health Future By 2040: Key Projections For Population And Workforce In Developmental-Behavioural Paediatrics, Watfa Al-Mamari, Ahmed B. Idris, Rola Al-Balushi, Kamila Al-Alawi, Saquib Jalees, Ahmed Al-Saidi

Sultan Qaboos University Medical Journal

No abstract provided.


Integration Of Renewable Energy Networks Into Smart Grid Infrastructure: A Matlab/Simulink-Based Simulation Approach, Saturday Noghayin Osaretin Dec 2025

Integration Of Renewable Energy Networks Into Smart Grid Infrastructure: A Matlab/Simulink-Based Simulation Approach, Saturday Noghayin Osaretin

Electrical Engineering Theses

The rising demand for sustainable and resilient energy systems has accelerated the transformation from traditional power grids toward smart grids integrated with renewable energy networks. This thesis explores the integration of solar energy sources into smart grids to replace conventional fossil-fuel-based generation. A simulation model is developed using MATLAB/Simulink to evaluate the operational performance, stability, and adaptability of the proposed smart grid architecture. Key challenges, including intermittency, synchronization, and bidirectional power flows, are identified, and corresponding solutions, such as energy storage systems, are proposed to address these issues. Simulation results demonstrate enhanced grid stability, reduced carbon footprint, and improved power …


Exploring The Individual Relationships Of Mothers' And Fathers' Parenting Styles With Emerging Adults' First-Term Gpa, Tiffany Fox Okeke Dec 2025

Exploring The Individual Relationships Of Mothers' And Fathers' Parenting Styles With Emerging Adults' First-Term Gpa, Tiffany Fox Okeke

Theses and Dissertations

Parenting styles have most often been studied through the lens of adolescent academic outcomes but less is known about how mothers' and fathers' parenting styles influence academic performance separately, especially during the critical transitionary period to post-secondary education. This study examines how mothers' and fathers' parenting styles distinctly shape emerging adults' first-term academic outcomes during their postsecondary education, with a focus on the dimensions of parental warmth and control. The study uses the National Longitudinal Survey of Youth 1997 dataset and the NLSY97 Post-Secondary Transcript Data focusing on the 1997-2005 cohorts (N=3,478) along with OLS regression analyses to predict emerging …


A Comprehensive Study Of Integration And Alternatives For Concrete In The Construction Industry, Saee Sawlikar Dec 2025

A Comprehensive Study Of Integration And Alternatives For Concrete In The Construction Industry, Saee Sawlikar

Theses

Concrete dominates the building industry as a construction material, frequently used due to its versatile, enormous application properties and the flexibility it offers. When just traditional concrete is considered, it contributes to only 8% of the total global warming potential. However, due to its countless vast applications, it’s energy and emissions consumption is up to roughly 35% and 38% respectively when compared with other industries. The study focuses on proposing three alternative low-carbon concrete materials with modified component chemical properties with reference to concrete itself and will test if any material could replace and surpass the benefits offered by concrete …


Relationship Between Muscle Activation And Kinematic Features During Baseball Pitching, Maxwell Skene Dec 2025

Relationship Between Muscle Activation And Kinematic Features During Baseball Pitching, Maxwell Skene

Theses

Background: Baseball pitching is a biomechanically complex, high-velocity movement that places substantial demands on the upper extremity. Inefficient coordination between muscle activation and kinematic sequencing has been associated with reduced performance and increased injury risk, particularly at the shoulder and elbow. However, the integrated relationship between muscle activation patterns and three-dimensional kinematic features during pitching is not well-documented. Purpose: The purpose of this study was to examine the relationship between throwing-arm muscle activation patterns and three-dimensional kinematic characteristics during fastball pitching, with particular emphasis on segmental accelerations, proximal–distal sequencing, and the directional structure of movement quantified using Relative Dimensional Contribution …


Rapid Detection Of Chicken Residues On Poultry Plant Surfaces Using Color And Fluorescence Spectrometry, Clark Griscom, Dongyi Wang, Corliss A. O'Bryan, Rimmo Room, Philip G. Crandall Dec 2025

Rapid Detection Of Chicken Residues On Poultry Plant Surfaces Using Color And Fluorescence Spectrometry, Clark Griscom, Dongyi Wang, Corliss A. O'Bryan, Rimmo Room, Philip G. Crandall

Food Science Faculty Publications and Presentations

Color and fluorescence spectrometry were evaluated as rapid, objective tools for verifying the cleanliness of poultry-processing food-contacting surfaces contaminated with a model chicken solution across six common materials. Both techniques detected chicken residues at dilutions several orders of magnitude below human visual and olfactory thresholds, with stainless steel and blue plastic yielding the largest color differences between clean and contaminated states and fluorescence measurements remaining highly sensitive on all tested surfaces. Representative limits of detection were on the order of 1:50-1:100 dilution of chicken residue for color measurements on most surfaces and approximately 1:50 for fluorescence measurements, compared with human …


Matter Of Mantilla V. New York City Dept. Of Hous. Preserv. & Dev. Dec 2025

Matter Of Mantilla V. New York City Dept. Of Hous. Preserv. & Dev.

All Decisions

In this CPLR article 78 proceeding, the Court of Appeals affirmed the denial of a tenant's succession rights to a deceased brother's Mitchell-Lama apartment. The landlord (HPD) found the tenant failed to prove primary residency for the required one-year period prior to the brother's death, despite being an eligible family member and listed on income affidavits. While the tenant presented some evidence like SNAP correspondence and power of attorney over the brother's bank account, the Court held the agency had a rational basis for concluding this was insufficient. The Court emphasized its deferential standard of review for administrative determinations, upholding …


Spatial Conversations: Opportunities To Share Geographic Knowledge, L. Jesse Rouse, Barbara L. Maclennan, Susan J. Bergeron, H. Franklin Lafone Dec 2025

Spatial Conversations: Opportunities To Share Geographic Knowledge, L. Jesse Rouse, Barbara L. Maclennan, Susan J. Bergeron, H. Franklin Lafone

Anthropology and Geography

For more than twenty years geographers have taken advantage of “new media” to share information, make connections, and expand the “spatial conversation.” As blogs opened the door for informal self-publishing and communicating about narrow, focused topic areas, geographers began to use emerging media platforms to present ideas to a broader audience, more quickly and interactively, as new data and technologies became available. Audio podcasts and videos broadened the platforms for dissemination and provide a greater level of immersion through digital media. Between the open publishing and subscription opportunities, and interaction provided through comments and social media engagement, a dialectic was …


Sustainability Strategies For Independent, Quick-Service Restaurant Businesses To Survive Beyond 5 Years, Winston Daniel Pauley Dec 2025

Sustainability Strategies For Independent, Quick-Service Restaurant Businesses To Survive Beyond 5 Years, Winston Daniel Pauley

Walden Dissertations and Doctoral Studies

Independent quick-service restaurant owners face challenges sustaining their businesses beyond 5 years of operation. Many independent quick-service restaurant owners are concerned about maintaining sustainable business operations, as failure can negatively affect owners, employees, and the communities they serve. Grounded in the resourcebased view theory, the purpose of this qualitative pragmatic inquiry project was to explore the successful sustainability strategies that quick-service restaurant owners used to survive beyond 5 years. The participants were six independent, quick-service restaurant owners operating in the state of Maryland who employed effective sustainability strategies to survive for more than 5 years. Data were collected using semistructured …


The Ascot App – A Plant Tracking Smartphone Tool For Field-Based Community Science, Demian A. Willette, Aaron W. Floreani, Stephanie A. Flores, Milla P. Markovic, Coby T. Sanders, Evan Yu, John David N. Dionisio Dec 2025

The Ascot App – A Plant Tracking Smartphone Tool For Field-Based Community Science, Demian A. Willette, Aaron W. Floreani, Stephanie A. Flores, Milla P. Markovic, Coby T. Sanders, Evan Yu, John David N. Dionisio

Cities and the Environment (CATE)

Urban tree planting efforts have accelerated globally, but systematic monitoring of planted trees, particularly of survivorship and growth, lags behind. To help address this challenge, we developed and implemented the Ascot App, a free, mobile-based tool designed to streamline citizen science data collection in urban habitat restoration projects. Deployed at a Miyawaki-style microforest in Ascot Hills Park, Los Angeles, the app enables volunteers with minimal training to scan QR-coded tags on seedlings and submit standardized, timestamped plant health data via an intuitive interface. The app reduces user error through simplified prompts and integrates directly with a web-based administrative portal for …


Status Of Training In The Use Of Lumen-Apposing Metal Stents For Therapeutic Endoscopic Ultrasound During Advanced Endoscopy Fellowship: A Survey Questionnaire, Yasi Xiao, Maham Hayat, Abdul S. Mohammed, Abdullah Abbasi, Sagar Pathak, Saurabh Chandan, Daryl Ramai, Deepanshu Jain, Muhammad K. Hasan, Mustafa A. Arain, Kambiz K. Kadkhodayan, Natalie Cosgrove, Dennis Yang Dec 2025

Status Of Training In The Use Of Lumen-Apposing Metal Stents For Therapeutic Endoscopic Ultrasound During Advanced Endoscopy Fellowship: A Survey Questionnaire, Yasi Xiao, Maham Hayat, Abdul S. Mohammed, Abdullah Abbasi, Sagar Pathak, Saurabh Chandan, Daryl Ramai, Deepanshu Jain, Muhammad K. Hasan, Mustafa A. Arain, Kambiz K. Kadkhodayan, Natalie Cosgrove, Dennis Yang

Division of Gastroenterology and Hepatology Faculty Papers

Background and Aims The lumen-apposing metal stent (LAMS) has revolutionized endoscopic ultrasound (EUS). However, there is a paucity of data on the optimal approaches to training on the use of LAMSs. This survey study aimed to evaluate the status of training in LAMSs among advanced endoscopy fellowship (AEF) trainees. Methods AEF (academic year 2023-2024) trainees were invited to complete a 15-question survey on LAMS training. The questions included the following domains: demographics, exposure to LAMSs before AEF, number of observed and hands-on participation using LAMSs for EUS-guided pancreatic fluid collection drainage (EUS-PFCD), choledochoduodenostomy (EUS-CD), gallbladder drainage (EUS-GBD), and gastrojejunostomy (EUS-GJ) …


Factors Influencing The Choice Of Neurology As A Specialty Among Medical Students And Physicians In Saudi Arabia: A Cross-Sectional Study, Muhannad A. Alahmadi, Moath M. Alomairi, Aseel O. Banasir, Omar Babateen Dec 2025

Factors Influencing The Choice Of Neurology As A Specialty Among Medical Students And Physicians In Saudi Arabia: A Cross-Sectional Study, Muhannad A. Alahmadi, Moath M. Alomairi, Aseel O. Banasir, Omar Babateen

Saudi Toxicology Journal

Neurological disorders represent a substantial global health burden and contribute to the rising demand for neurologists. In Saudi Arabia, the shortage of neurologists underscores the importance of understanding how medical students and physicians perceive neurology as a career. This study aimed to explore the level of interest in neurology and identify factors influencing specialty selection. This cross-sectional study was conducted between November and December 2024 among undergraduate medical students and medical graduates (residents, fellows, specialists, and consultants) in Saudi Arabia. First-year students and those without prior exposure to neurology were excluded. Data were collected through a structured online questionnaire distributed …


Trematodes Detected In An Exotic Population Of Red Swamp Crayfish From An Urban Storm Drain In Los Angeles, Jason M. Post, Emily S. Bailey, Rachael J. Post Dec 2025

Trematodes Detected In An Exotic Population Of Red Swamp Crayfish From An Urban Storm Drain In Los Angeles, Jason M. Post, Emily S. Bailey, Rachael J. Post

Cities and the Environment (CATE)

The red swamp crayfish, Procambarus clarkii is an exotic aquatic crustacean with global prevalence. Native to the Southeastern United States, this species has been introduced for aquaculture as it is a popular food fishery resource. A well-documented host for trematodes, P. clarkii is a known vector for parasitic, fungal, and viral infections. Procambarus clarkii has demonstrated the ability to consume exotic snails such as Melanoides tuberculata as a means of controlling snail-borne infections. In this study, an isolated exotic P. clarkii specimen was collected from an urban waterway in Los Angeles, California adjacent and draining into the largest remaining wetland …


Why Do People Use Rat Poison To Manage Rats? A Mixed Methods Study In A Large American City, Maureen H. Murray, Danielle German, Jacqueline Y. Buckley, Seth B. Magle, Kaylee A. Byers Dec 2025

Why Do People Use Rat Poison To Manage Rats? A Mixed Methods Study In A Large American City, Maureen H. Murray, Danielle German, Jacqueline Y. Buckley, Seth B. Magle, Kaylee A. Byers

Cities and the Environment (CATE)

Commensal rats are managed worldwide using rat poisons known as anticoagulant rodenticides (ARs). ARs are a global health and conservation issue as they sicken and kill non-target animals that consume bait or poisoned rats. The public can use AR bait to manage rats without oversight, and so understanding why people use ARs is critical to reducing public use of, and demand for, ARs. We used a sequential explanatory mixed methods approach to examine 1) urban residents’ perceptions and use of rat poison, 2) drivers of rat poison use, and to 3) describe the reasons that poison was used. We surveyed …


Investigating The Regulatory Impact Of Non-Coding Rnas On Meis1, Salma Fahim Dec 2025

Investigating The Regulatory Impact Of Non-Coding Rnas On Meis1, Salma Fahim

Theses and Dissertations

Myeloid ecotropic virus insertion site 1 (MEIS1) is a transcription factor involved in a myriad of functions such as hematopoiesis, cardiac regeneration, cell cycle progression, cell proliferation, and limb and organ development. Precise control of MEIS1 expression and function is essential for maintaining cellular homeostasis and preventing pathological conditions including cancer. Emerging evidence suggests that non-coding RNAs (ncRNAs) play a significant role in fine-tuning MEIS1 activity. Unmasking these regulatory mechanisms could provide potential therapeutic strategies for conditions where MEIS1 is aberrantly expressed. The present dissertation presents a comprehensive overview of current knowledge on MEIS1, synthesizing findings from the literature to …


The Role Of Dust Inputs And Sediment Phosphorus Diffusion Into Utah Lake, Utah, United States Of America, Kristen E. Smith Dec 2025

The Role Of Dust Inputs And Sediment Phosphorus Diffusion Into Utah Lake, Utah, United States Of America, Kristen E. Smith

Theses and Dissertations

Human activities have led to excessive nutrient enrichment which is greater than lake systems can naturally assimilate. This process is known as eutrophication and it is driving significant algae growth resulting in the more common release of harmful toxins. Utah Lake, located in Utah County, UT is one such water body that even after major reductions in anthropogenic phosphorus influent, continues to experience frequent, harmful algal blooms. The extent to which natural processes, like atmospheric dust deposition and sediment recycling, contribute to the lake's phosphorus budget is still poorly understood.

To address this gap of knowledge, this study quantified phosphorus …


Staff Education To Improve Patient Medication Adherence For Schizophrenia Using Long-Acting Injectables, Adela Ghogomu Dec 2025

Staff Education To Improve Patient Medication Adherence For Schizophrenia Using Long-Acting Injectables, Adela Ghogomu

Walden Dissertations and Doctoral Studies

This doctoral project was conducted as a staff education initiative based on a comprehensive literature review that emphasized the importance of staff education in improving healthcare outcomes. The practice problem identified was a lack of staff knowledge and education regarding long-acting injectables (LAIs) in clients with schizophrenia, which contributed to inconsistent support for client medication adherence. It was essential to address this issue because nurses play a crucial role in medication management, patient education, and adherence support. The practice-focused question explored was: Will staff education regarding the use of long-acting injectables in clients with schizophrenia to enhance medication adherence improve …


Teachers’ Perceptions Of Employer-Provided Afterschool Childcare As A Retention Strategy: A Herzberg-Informed Qualitative Case Study, Lakinsha R. Swinton Dec 2025

Teachers’ Perceptions Of Employer-Provided Afterschool Childcare As A Retention Strategy: A Herzberg-Informed Qualitative Case Study, Lakinsha R. Swinton

Walden Dissertations and Doctoral Studies

Teacher retention has been a growing issue, as the rate of teacher vacancies has continued to increase after the COVID-19 pandemic. The increase in teacher vacancies after the pandemic highlighted the importance of retaining and attracting highly qualified teachers for schools and school districts. A coastal South Carolina school district had been providing employee support services to retain current staff and create a competitive advantage over other school districts in attracting new staff. The purpose of this generic qualitative study is to examine the perception of classroom teachers regarding the efficacy of free afterschool childcare as an employee support service …


Attitudes And Perception Of Lis Students Towards Artificial Intelligence(Ai), Shahzadi Humbhi, Shabbir Tareen, Alia Humbhi Dec 2025

Attitudes And Perception Of Lis Students Towards Artificial Intelligence(Ai), Shahzadi Humbhi, Shabbir Tareen, Alia Humbhi

Library Philosophy and Practice (e-journal)

Artificial Intelligence refers to computer systems that can think and behave like humans. It is becoming essential in the education system as it has the potential to transform the way of teaching and learning in an academic environment. Therefore, the current study aims to investigate LIS students' attitudes and perceptions of AI, as well as how these technologies benefit their academic performance. The study also identified barriers that LIS students confront when adopting AI tools. For this purpose, a survey questionnaire was designed to assess students' knowledge and attitudes concerning AI, as well as its applications to improve academic performance. …


Life-Threatening Bradycardia In Anti-Nmda-Receptor Encephalitis And A Novel Use For Permanent Pacing, Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A Smitherman, Heather Van Mater, Taylor Howard, Alexander J Sandweiss, Kristen S Fisher Dec 2025

Life-Threatening Bradycardia In Anti-Nmda-Receptor Encephalitis And A Novel Use For Permanent Pacing, Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A Smitherman, Heather Van Mater, Taylor Howard, Alexander J Sandweiss, Kristen S Fisher

Faculty, Staff and Students Publications

Background: Pediatric anti-NMDA receptor encephalitis (pNMDARE) is an autoantibody-mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.

Objective: To describe outcomes of 5 pNMDARE patients with life-threatening bradycardic and/or asystolic events who were managed with permanent or semi-permanent pacemaker implantation.

Methods: We performed a retrospective chart review of 5 patients from multiple institutions. We included patients with a diagnosis of pNMDARE (confirmed by positive cerebrospinal fluid and/or serum anti-NMDAR antibodies) who had a permanent or semi-permanent pacemaker placed due to symptomatic bradycardia, sinus pauses, and/or …


Mechanistic And Functional Characterization Of Abtb2 As A Novel Target For Pancreatic Cancer Therapy, Nan Lyu, Olamide T Olaoba, Qiongling Wang, Harinarayanan Janakiraman, Xinjian Liu, Ernest Ramsay Camp, Kun Cheng, Eric T Kimchi, Yi Miao, Kevin F Staveley-O'Carroll, Guangfu Li Dec 2025

Mechanistic And Functional Characterization Of Abtb2 As A Novel Target For Pancreatic Cancer Therapy, Nan Lyu, Olamide T Olaoba, Qiongling Wang, Harinarayanan Janakiraman, Xinjian Liu, Ernest Ramsay Camp, Kun Cheng, Eric T Kimchi, Yi Miao, Kevin F Staveley-O'Carroll, Guangfu Li

Faculty, Staff and Students Publications

BTB/POZ domain-containing proteins are increasingly recognized for their context-dependent roles in cancer, acting as either tumor suppressors or oncogenic drivers depending on the cancer type. Among them, the function of ankyrin repeat and BTB domain-containing protein 2 (ABTB2) in pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy, has remained unexplored. In this study, we employed comprehensive functional genomics approaches—siRNA/shRNA knockdown, CRISPR-Cas9 knockout, plasmid-based overexpression, and a Cre-LoxP transgenic mouse model—to systemically modulate ABTB2 expression in human and murine PDAC cell lines, as well as in the KPC mouse model of PDAC. Our gain- and loss-of-function studies revealed that ABTB2 plays …


Mineralocorticoid Receptor Antagonists For Acute Myocardial Infarction: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Song Peng Ang, Jia Ee Chia, Bruno Bezerra Lima, Jose Iglesias, Eunseuk Lee, Chayakrit Krittanawong, Mahboob Alam, Debabrata Mukherjee Dec 2025

Mineralocorticoid Receptor Antagonists For Acute Myocardial Infarction: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Song Peng Ang, Jia Ee Chia, Bruno Bezerra Lima, Jose Iglesias, Eunseuk Lee, Chayakrit Krittanawong, Mahboob Alam, Debabrata Mukherjee

Faculty, Staff and Students Publications

Background: The role of mineralocorticoid receptor antagonists (MRAs) in acute myocardial infarction (MI) remains controversial, with conflicting evidence from landmark trials. We aimed to assess the impact of MRAs on mortality and cardiovascular outcomes post-acute MI.

Methods: We systematically searched PubMed, Embase and Cochrane CENTRAL databases up to February 2025 for randomised controlled trials comparing MRAs with placebo or standard care in adults experiencing acute MI. Primary outcome was all-cause mortality; secondary outcomes included cardiovascular mortality, heart failure, recurrent MI and ventricular arrhythmia. Data were pooled using random-effects models, with heterogeneity explored via subgroup analyses and meta-regression.

Results: 15 trials …