Digital Commons Network^™

Accuracy Of Voluntary Force Modulation During The Isometric Mid-Thigh Pull, S. Alexander Long, Olivia Vadas, Stephanie Balint, Michael H. Stone, Christopher Taber

Exercise Science Faculty Publications

The purpose of this study was to investigate voluntary force modulation accuracy during the isometric mid-thigh pull (IMTP) and to investigate biological sex and relative strength as factors relating to error. Strength-trained males (n = 18) and females (n = 18) completed ascending (ASC) (25%, 50%, 75%) or descending (DESC) (75%, 50%, 25%) submaximal testing followed by maximal testing. Subjects rested before completing the opposite submaximal testing sequence. External feedback was not provided during testing. Measured and intended (INT) forces were analyzed with two-way repeated-measures ANOVAs with within- (ASC, DESC, and INT) and between-subject factors (male or female). Independent-samples t-tests …

Rampcast Phase Ii: Connected Vehicles Traffic Management Application On Indiana Highways, Abin Mathew, Agnideven Palanisamy Sundar, Juntong Peng, Jue Zhou, Yaobin Chen, Feng Li

JTRP Technical Reports

This project advances connected vehicle applications by developing and testing an enhanced RampCast system, a comprehensive traffic management system using C-V2X technology for Indiana highways. The system features a dual-mode architecture integrating both short-range (PC5) and long-range cellular (Uu) C-V2X communication pathways, utilizing commercial-grade Cohda MK6 hardware and adhering to SAE J2735 standards to ensure interoperability. A key innovation is the integration of an AI-based prioritization framework, which leverages a large language model to enhance the contextual relevance of traffic messages. This AI system introduces two intelligent agents: one to dynamically estimate the appropriate display distance for an event based …

Pedestrian And Bicyclist Trespassing Impacts On Rail Grade Crossings Safety And Mobility, Shanyue Guan, Siqi Chen, Shufan Liu, Samy Noureldin, Bridgette Hail, Brandon Burgoa, Elizabeth Mouser, Alison Shaner, Paige Story, Karen Stippich

JTRP Technical Reports

Highway roads intersect with a railroad track, forming a multimodal transportation system. The intersection is called a highway railroad grade crossing (HRGC). Because of the multiple transportation operations, induced conflict at the grade crossing, crashes may happen between road users (e.g., automobiles, pedestrians, bicyclists, etc.) and trains in operations at highway railroad grade crossings. This is a global challenge for many countries around the world. According to the 2022–2026 Indiana Strategic Highway Safety Plan and 2022 Indiana Highway-Rail Grade Crossing Safety Action Plan, one of the biggest challenges facing Indiana is the higher numbers of pedestrians in and around crossing …

Development Of Dashboards And Procedures For Using Connected Vehicle Data To Prioritize Investments In Electric Vehicle Related Infrastructure, Jairaj C. Desai, Nathaniel J. Sturdevant, George Mccue, Darcy M. Bullock

JTRP Technical Reports

The National Electric Vehicle Infrastructure (NEVI) Formula Program and the Charging and Fueling Infrastructure Discretionary Grant Program together provide $7.5 billion to support states with building out a nationwide EV charging network. Indiana’s Charging the Crossroads program, funded through the NEVI program, plans to invest almost $100 million to build an EV charging network along Indiana interstates and highways. There is broad consensus among states, that these fast charging station investments should be based upon quantitative geospatial data with the objective of maximizing the impact of the NEVI program investments.

However, traditional methods for monitoring electric vehicle (EV) usage have …

Feasibility Study On The Development Of Indiana’S Connected And Automated Vehicle Roadmap And Strategic Plan, Can Cui, Juanwu Lu, Yupeng Zhou, Abin Mathew, Jue Zhou, Ziran Wang, Yaobin Chen

JTRP Technical Reports

This study provides INDOT with critical insights into major OEMs’ connected and autonomous vehicle (CAV) development plans and related research and demonstration activities in several surrounding states, guiding infrastructure investment and policy decisions. The report delivers three outputs that guide the CAV technologies implementation in Indiana. First, it synthesizes the best regional practices and industry direction to distinguish what is feasible now from what requires further development. Second, it establishes a technical baseline that links priority applications to sensing and communications architectures with explicit attention to interoperability, security, and maintainability. Third, it defines an implementation framework that connects capital and …

Identify Bridge Design Guidelines For Wildlife Crossings, Jon Padfield, Kyle Squillace

JTRP Technical Reports

Annual vehicle miles driven in the United States doubled, from 1.6 trillion to 3.2 trillion in the 40 years between 1983 and 2023. Unfortunately, one side effect of the increase in vehicle miles driven has been the prevalence of Animal-Vehicle Collisions (AVCs).

As early as 1975, efforts began in some Western states to create safe animal passages such as the wildlife overpass over I-15 in Beaver, Utah. Wildlife passages increased in popularity from the 1970s through the 1990s, but they were mainly being designed and constructed in the Western United States.

Today, there is increasing and broader interest in safe …

Research Support To Indot On Systemwide Asset Condition Assessment Using Connected Vehicle Data, Andrew Thompson, Jairaj Desai, Rahul Suryakant Sakhare, Darcy M. Bullock

JTRP Technical Reports

Crowdsourced pavement roughness data using connected vehicles now provides cost-effective, high-resolution condition monitoring in near real-time. This study evaluates how connected vehicle data can support effective investment prioritization across Indiana’s road network and improve upon traditional data sources using surveys that are often done annually or biennially. A key challenge is handling terabyte-scale geospatial roughness datasets and integrating them meaningfully into asset management workflows. A scalable data processing methodology is outlined to address this issue and is used for the subsequent analysis.

This report’s analysis uses more than 3 billion daily CV-estimated roughness measurements (IRICVe) from 2022–2025, in addition to …

Portable Driving Simulation Platform For Innovative Intersections, Luyang Jiang, Zihao Li, David Chen, Blake Edwards, Angel Rivera Cardenas, George Takahashi, Brandon Pitts, Ziran Wang

JTRP Technical Reports

This report presents a portable driving simulation platform developed to improve public understanding and evaluation of innovative intersection designs. Built in Unity, the system integrates real-world roadway data with modular traffic and vehicle simulation to create realistic, interactive driving scenarios. Results show the platform effectively supports driver learning and stakeholder engagement, demonstrating its feasibility as a tool for education, safety analysis, and deployment support of innovative intersections.

Review Of Aashtoware Pavement Me Design Version 3.0, Jusang Lee, Jongmyung Jeon, John E. Haddock

JTRP Technical Reports

This study evaluated the differences between AASHTOWare Pavement ME Design (PMED) Version 2.6 and Version 3.0 using representative Indiana pavement structures and traffic conditions. PMED Version 3.0 introduces several major updates, including adoption of the MERRA-2 climate database, revised rigid pavement slab-base interaction models, updated calibration coefficients, and support for Multiple Stress Creep Recovery (MSCR)-based asphalt binder grading. Because the Indiana Department of Transportation (INDOT) currently uses PMED Version 2.6 with locally calibrated distress models, evaluation of Version 3.0 was necessary prior to implementation. A total of 114 pavement design files representing full-depth asphalt pavements, asphalt overlay pavements, and Portland …

Utilizing Emergency Management Audio Messages For Traffic Incident Management Performance Measures, Christopher Gartner, Vihaan Vajpayee, Jairaj Desai, Darcy M. Bullock

JTRP Technical Reports

Timely and accurate information regarding roadway incidents is critical for Traffic Management Centers (TMCs) to maintain safety and mobility. While Intelligent Transportation Systems (ITS) cameras and crowdsourced data provide significant visibility, rural interstate corridors often suffer from coverage gaps, or "blind spots," where incidents go undetected until significant queuing occurs. Public safety radio communications serve as the primary coordination method for first responders, creating a "verbal infrastructure" that contains vital information regarding incident location and severity. This study evaluates the feasibility of using Automatic Speech Recognition (ASR) to bridge these gaps by monitoring and analyzing radio traffic. The project developed …

Physics-Based Modelling Of Concrete Degradation Phenomena: Impact Of Construction Defects On Long Term Cost And Material Properties, Manuel Salmeron, Oscar D. Forero, Talha Faiz Mohammed, Kabir Shrivastava, Shirley J. Dyke, Julio A. Ramirez

JTRP Technical Reports

The quality of workmanship and adherence to specifications during the bridge construction phase of concrete decks, slabs, and continuous T-beams, are key factors on which future structural performance and durability hinge. If construction practices do not meet the required standards of quality, they may trigger early onset of deterioration processes that shorten the service life leading to unplanned interventions or unscheduled repairs, thus intensifying the need for maintenance actions and increasing costs during the service life of the bridge. Despite the consensus view that substandard construction practices reduce the performance of concrete structures, quantifying the impact is challenging. This difficulty …

Receiver, Vehicle, And Roadway Systems For A Dynamic Wireless Power Transfer Roadway Testbed, Oscar Andrés Moncada, Isaac Abram, Nicholas Frooninckx, Vatan Mehar, Chiara Cervini, O'Brien Ben, Bruno Cesar Krause Moras, Steve Pekarek, John E. Haddock, Dionysios Aliprantis, Aaron Brovont, Konstantina Gkritza, Rob Swanson

JTRP Technical Reports

A dynamic wireless power transfer (DWPT) system using a novel three-phase transmitter/receiver design was embedded 2.4 in beneath the surface of an existing rigid pavement on US 52/US 231 in West Lafayette, Indiana, with 85 coils installed and paired with a retrofitted Class-8 Cummins electrified truck. The system successfully delivered 50–190 kW at speeds up to 65 mph with efficiencies approaching 85%, and all coils met electromagnetic balance targets; similar results were validated on a 3-coil testbed at Utah State University, with magnetic flux densities well below human exposure limits. Testing also demonstrated strong misalignment tolerance and reliable high-power delivery …

Simulating Current And Future Ev Growth Scenarios In Indiana, Omar Faruqe Hamim, Xiaowei Chen, Kenny Chandra Wijaya, Lavan Teja Burra, Zengxiang Lei, Rajat Verma, Konstantina (Nadia) Gkritza, Satish Ukkusuri

JTRP Technical Reports

As Indiana transitions toward electric mobility, data-driven planning is essential to guide electric vehicle (EV) charging infrastructure investment and deployment. This study evaluates the current and future performance of Indiana’s EV charging infrastructure using Multimodal Energy-Efficient Trip Simulation in Real Time (METS-R), a high-resolution simulation platform. Five EV adoption scenarios, ranging from pessimistic to optimistic, are modeled for the years 2024 through 2031, to assess spatial and temporal variations in public charging demand. Results reveal increasing public charging demand under high adoption scenarios, with significant disparities between urban and non-urban areas. Accessibility to public charging is found to be uneven …

Implementation Study For In-Place Testing Of Asphalt Treated Cold Recycled Pavements, Pablo Orosa Iglesias, Cheng Zhang, Daniel Mauricio Santamaria, John E. Hadddock

JTRP Technical Reports

This study evaluated the feasibility of rapid in-situ strength test methods for asphalt-treated cold recycled (ATCR) pavements in Indiana, with a secondary objective of characterizing the dynamic modulus of a locally produced ATCR mixture for use as AASHTOWare Pavement ME Design inputs. The long-pin shear test (LPST) and short-pin raveling test (SPRT), developed through National Cooperative Highway Research Program (NCHRP) Project 09-62, were evaluated on a cold in-place recycling (CIR) project on SR 13 in Greenfield, Indiana. Field results for blow counts exceeded the proposed NCHRP threshold moments after compaction, with torque values approaching but not yet reaching the NCHRP …

Evaluation Of Aggregate Gradation Specifications And The Feasibility Of Harmonization With Aashto Standards, Husam Elgaali, Ayesha Shah, Jan Olek

JTRP Technical Reports

The aggregate gradations specified by the Indiana Department of Transportation (INDOT) differ from those of the American Association of State Highway and Transportation Officials (AASHTO). Preliminary discussions suggest that adopting AASHTO standard gradation sizes could provide national alignment and simplify production for those operating in multiple states and supplying projects not subject to INDOT specifications. A comprehensive study was performed to evaluate the current INDOT specifications for coarse and fine aggregate gradations and to assess the potential impacts and feasibility of adopting AASHTO-specified gradations. A comparative analysis of INDOT gradations against AASHTO, ASTM International (ASTM), and those of neighboring states …

Bridge Data Virtual Validator, Jiansong Zhang, Bo Pang, Meta Soy, Bernard Nartey, Yunfeng Chen

JTRP Technical Reports

This report presents Bridge Data Virtual Validator, which is a prototype web-based tool developed to support automated quality assurance (QA) of INDOT bridge project deliverables. The project focuses on Final Tracings documents, where important bridge data are distributed across bridge plans, cost estimates, and other documents/elements. Two validation components were developed. The first component supports bridge plan format compliance checking by using optical character recognition (OCR), computer vision, and rule-based reasoning to identify missing or inconsistent letting control information such as file numbers, dates, stamps, signatures, and sheet numbers. The second component performs comparative checking of pay items between bridge …

Development Of Indiana-Specific Trip Generation Procedures And Models Of E-Commerce Demand: Implications For Indot’S Travel Demand Modeling And Investment Planning, Rishika Srinivasa Tumula, Zhuoli Yin, Hua Cai, Nadia Gkritza

JTRP Technical Reports

This study aims to improve Indiana’s travel demand modeling practices by incorporating locally collected trip generation data and emerging e-commerce travel trends into INDOT’s planning framework. The research focuses on two primary objectives. First, it enhances trip generation procedures for high-impact land uses in Indiana, including warehouses, fast-food restaurants, gas stations, and truck stops. This effort includes reviewing existing ITE land use categories, prioritizing land uses for phased data collection, and developing improved trip generation equations that incorporate Indiana-specific independent variables and adjacent traffic conditions. Second, the study develops models to capture the transportation impacts of rapidly evolving e-commerce behavior. …

Levonorgestrel Intrauterine System Use And The Risk Of Cervical Cancer In Women With Human Papillomavirus, Britney Margheim, Lauren Zakshorn, Sadie Wiens

Student Publications

No abstract provided.

Surgery And The Role Of Biologics In Chronic Rhinosinusitis With Nasal Polyps: A Narrative Review, Claire Hopkins, Wytske J. Fokkens, Joseph K. Han, Shigeharu Fujieda, Osama Marglani, Scott Nash, Mark Corbett, Amr Radwan, Yamo Deniz, Paul Rowe, Richard J. Harvey

Department of Otolaryngology (ENT) Faculty Publications

Background

Biologic treatments have helped progress the management of severe chronic rhinosinusitis with nasal polyps (CRSwNP) by targeting the mediators and effectors underlying chronic type 2 inflammation. This review considers the impact of biologics on endoscopic sinus surgery (ESS) in CRSwNP.

Methods

We conducted a comprehensive literature search through March 31, 2025.

Results

ESS as part of holistic management with topical anti-inflammatory treatment is very effective at improving symptoms and quality of life in patients with severe CRSwNP. The criteria for eligibility for surgery are not standardized and there is wide variation in surgery rates between regions. Despite regular post-operative …

Frontline Aspiration Versus Stent Retriever Thrombectomy For M2 Occlusions: Insights From The Star Registry, Michael Gaub, Joshua Osbun, Et Al.

2020-Current year OA Pubs

BACKGROUND: Recent trials have furthered uncertainty regarding the endovascular benefit for medium vessel occlusions (MeVO). Stent retrievers (SR) were employed in the first attempt in most interventional arm participants. We sought to compare outcomes in acute MCA M2 occlusions between frontline aspiration and SR, and to delineate procedural and anatomical covariates associated with differential treatment effect.

METHODS: Retrospective analysis of a multicenter stroke thrombectomy cohort identified cases of MT for M2 occlusions. Unmatched and propensity score-matched (PSM) cohorts were generated comparing frontline aspiration to standalone and combined SR. The primary outcome was functional independence (mRS 0-2) at 90 days. Recanalization, …

A Neo-Kuyperian Approach To Mathematics, Calvin Jongsma, Kevin Vander Meulen

Faculty Work Comprehensive List

This chapter develops a Reformational perspective on the discipline of mathematics that stems from the seminal ideas of Kuyper, Dooyeweerd, Wolters, Clouser, and others. The implications of the Biblical motif of Creation-Fall-Redemption is explored for the task of Christian scholarship in general and for the field of mathematics in particular, drawing upon relevant developments in the history and philosophy of mathematics.

Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.

2020-Current year OA Pubs

BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (HCC) generally experience poor outcomes despite current therapies, necessitating the development of alternative treatments. ADP-A2AFP is an investigational autologous T-cell therapy with an affinity-enhanced T-cell receptor (TCR) targeting alpha-fetoprotein (AFP).

METHODS: We describe a phase I, open-label, first-in-human clinical trial of ADP-A2AFP (NCT03132792) in human leukocyte antigen-eligible participants with AFP-expressing HCC (or other tumor) not amenable to transplant/resection who progressed on, were intolerant to, or refused prior systemic therapy. Participants received lymphodepletion chemotherapy (cyclophosphamide 500 mg/m

RESULTS: Twenty-one participants, 20 with advanced HCC and one with gastric hepatoid carcinoma received ≥1 ADP-A2AFP …

Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th

2020-Current year OA Pubs

Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …

Coordinated Regulation Of Capping Protein By Carmil And V-1/Myotrophin, John A Hammer, John A Cooper

2020-Current year OA Pubs

Capping Protein (CP) plays a central role in controlling actin filament dynamics in almost all eukaryotic cell types by virtue of its ability to block monomer addition and loss at the barbed end of the actin filament. Like other proteins that control actin assembly, CP is subject to regulation. Here we focus on two direct regulators of CP-CARMIL and V-1/Myotrophin. Specifically, we review recent biochemical, structural, imaging, and cell biological data that argue these two proteins cooperate to create a regulatory cycle for CP that controls its availability, activity, and site of action in the cell. Finally, we discuss unresolved …

Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True

2020-Current year OA Pubs

Limb-girdle muscular dystrophy D1 (LGMDD1) is a rare, dominantly inherited neuromuscular protein-misfolding chaperonopathy caused by mutations in the Hsp40 co-chaperone DNAJB6, primarily in the glycine-phenylalanine (GF) or J-domains. Currently, no treatments are available, and a challenge in understanding the disease is identifying a specific client protein for DNAJB6 in skeletal muscle. DNAJB6 has homology to the yeast DNAJ family member, Sis1. Our previous research indicated that LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity. Herein, we employed functional assays along with advanced molecular simulation studies to understand the regulatory interdomain interactions in disease-causing mutants of …

Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways, Steven J Wilhelm, Grace E Curry, Neel Matiwala, Jianguo Lin, Tran Quach, Mark E Lowe, Miklós Sahin-Tóth, Xunjun K Xiao

2020-Current year OA Pubs

BACKGROUND & AIMS: Increasing evidence suggests that protein misfolding and proteotoxicity is an important mechanism of chronic pancreatitis (CP) in patients with genetic variants. Two mouse models carrying misfolding digestive enzyme variants, CPA1 N256K and PNLIP T221M, recapitulate the human CP phenotype. We hypothesized that both models develop CP through similar disease mechanisms.

METHODS: We conducted a comprehensive analysis of mice aged 1 to 6 months using histology, immunohistochemistry, protein immunoblotting, quantitative polymerase chain reaction (qPCR), transmission electron microscopy (TEM), and RNA sequencing (RNA-seq) analysis to characterize pancreatic pathological changes.

RESULTS: Both homozygous models exhibited CP hallmarks, including progressive acinar …

A Deep Learning Model To Guide Personalized Mechanical Circulatory Support Use In Cardiogenic Shock Patients Undergoing Pci, Amit P Amin, Richard G Bach, Darren C Tsang, Weili S Zheng, Raed A Qarajeh, Emmanouil S Brilakis, Hemant Kulkarni

2020-Current year OA Pubs

BACKGROUND: Cardiogenic shock (CS) in patients undergoing percutaneous coronary intervention (PCI) involves rapidly changing clinical, hemodynamic, and metabolic factors that current models cannot effectively integrate.

OBJECTIVES: The purpose of this study was to develop and validate a deep learning (DL) model to guide personalized use of mechanical circulatory support (MCS) devices in CS patients undergoing PCI.

METHODS: The authors analyzed data from 1,408 CS patients treated with intra-aortic balloon pump (IABP) or microaxial flow-pump (mAFP) at multiple hospitals (2004-2019). Clinical, hemodynamic, and metabolic variables from admission to MCS placement were compiled into longitudinal vectors. Using Python 3.7 and TabNet in …

Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle

2020-Current year OA Pubs

INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.

DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …

Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings

2020-Current year OA Pubs

BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.

METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …

Identification Of Distinct Subtypes In Immune Tolerance After Hematopoietic Cell Transplantation Using The Prospective Able1.0 Pediatric Study Cohort, Bernard Ng, Shalini Shenoy, Et Al.

2020-Current year OA Pubs

The lack of immune tolerance after hematopoietic cell transplantation (HCT) can result in chronic graft-versus-host disease (cGvHD), which is the primary nonrelapse limitation of successful HCT. To date, immune tolerance has been considered a single biological entity, but we hypothesized that post-HCT immune tolerance could develop through multiple pathways. Using the ABLE network database, which comprises measurements of 75 cell populations, 10 cytokines and chemokines, lymphocyte population telomere length, KRECs and TRECs, and 132 metabolites from the largest pediatric cGvHD cohort (n = 241), we applied clustering analysis to patients with primary immune tolerance (PIT; no acute GvHD [aGvHD] or …