Digital Commons Network^™

In Silico Repurposing Of Fda-Approved Pleiotropic Metabolic Modulators For Alzheimer's Tau Protein, Maanya Chitrapu, Juhi Vora, Navi Gill Dhillon

Bioinformatics

Abstract: Alzheimer's Disease (AD) is characterized as "Type 3 Diabetes," where metabolic dysfunction drives Tau protein aggregation. This study uses in silico docking to compare the structural efficacy of three drug classes (Glucose, Lipid, and Cardio-Metabolic) against the Tau paired helical filament. 60 FDA-approved modulators were docked using CB-Dock2. Performance was tiered by Vina score thresholds: Elite (< -8.0 kcal/mol), Moderate (-6.0 to -7.9 kcal/mol), and Weak (> -6.0 kcal/mol). Cardio-Metabolic agents outperformed typical metabolic treatments. Digoxin resulted as the most "Ente' candidate (-9.0 kcal/mon. signincantiv surpassing the standard glucose regulator Mettormin (-4.5 kcal/mon. High-atmity binders also included Fluvastan (-8.2 kcalmon and telmisartan -8.2 kcal/mon. Mechanistcalv. Digoxin's olanar nucleus facintates …

Choco Pies, Economic Gains, And The Opening Of North Korea:, Quinci Rasband

BYU Asian Studies Student Journal

Since the armistice was signed putting a hold on the Korean War (July 27, 1953) and officially created two separate entities, has there ever been a time when North Korea and South Korea—two diametrically opposed countries— worked together towards a common goal? If there really was such a time when North Korea and South Korea collaborated, one can wonder how this was received in the minds of North Koreans and South Koreans. While it is challenging to understand North Korean citizens’ perceptions of events, delving into accessible sources can shed light onto South Korea’s viewpoint of inter-Korean relations. One such …

Memories Of The Low-Income Elderly Of South Korea, Jacob Gilbert

BYU Asian Studies Student Journal

Rain pattered against my umbrella as I walked down the small alleyway near Tapgol Park. An elderly man carrying a black umbrella hobbled past me. Rain dripping from the gutters made puddles at my feet. I carefully avoided several puddles in the pavement making my way to the end of the alleyway. As I drew closer to the end, loud voices echoed down the alley. Around the corner a crowd of elderly people huddled underneath the roof of the front gate to the park. Some stood, while others sat on the ground leaning their backs against the walls of the …

The Hallyu Hexagon:, Katherine Linton

BYU Asian Studies Student Journal

From the opening credits, Crash Landing On You1 captured the attention and adoration of millions. The show follows a South Korean chaebol heiress, Yoon Se-ri, who crash lands into the North Korean side of the Demilitarized Zone. She is discovered by North Korean soldier, Ri Jeong Hyeok, who mercifully decides not to kill her on the spot. Over the course of 16 episodes and 23 hours, as Ri Jeong Hyeok betrays loyalty lines by evading the North Korean Military Police and helping Yoon Se-ri return to the south, the two’s fateful meeting evolves into a cross-border romance.

Korean dramas are …

Silencing The Party, Amplifying The Music:, Brian Lewis

BYU Asian Studies Student Journal

The 2024 dissolution of the MFP marked a turning point in Thai electoral politics, catalyzing a cultural contest over political expression through music. The court’s decision to dissolve the MFP was perceived as a direct attack on free political discourse, intensifying state-led censorship efforts against musicians who critiqued the establishment. In response, political music became not only a means of protest, but a crucial space for youth to form their political identities and express dissent. This escalation in censorship and the concurrent surge in musical activism cannot be directly attributed to long-standing political trends; rather, they were significantly increased by …

Full Issue

BYU Asian Studies Student Journal

No abstract provided.

Colonial Legacy And National Identity:, Nina Harris

BYU Asian Studies Student Journal

The island of Taiwan occupies an unusual political position in the world today. Taiwan is viewed primarily in relation to its complicated relationship with the People’s Republic of China. While Taiwan considers itself distinct from the Chinese mainland, with its own constitution and democratically elected leaders, China’s government claims the island is an inalienable part of China and has been for centuries. Taiwan’s history, however, is more complicated and diverse than China allows. Unbeknownst to many, Taiwan was a Japanese colony from 1895 to 1945, and it was an era of highly significant change for Taiwan. The Japanese occupation was …

Connecting To The Motherland:, Grace Truett

BYU Asian Studies Student Journal

India was the crown jewel of the British Empire and, despite the oppressive colonialism between 1857 and 1947, it produced citizens who cared for the future of their nation. Jamini Roy is one such citizen who envisioned his rich cultural Motherland untouched by Western forces. Although India had been dominated by Britain economically, socially, and even artistically, Roy was an anti-capitalist artist who used materials native to India to perpetuate Bengali artistic traditions and reinvent Christian folklore; his work aims towards unification of Hindu, Muslim, and Christian Indian viewers through nationalism and connection of Indian citizens to their land, as …

Made For War, Abandoned In Peace:, Michelle Parada-Gonzalez

BYU Asian Studies Student Journal

Amid a raging blizzard in the mountains of 1907 Hokkaido, Sugimoto Saichi shelters inside the still-warm carcass of a freshly killed deer, huddled beside his companion, Asirpa. As she asks if his wounds still hurt, he brushes it off, insisting that the man he killed earlier had no human heart and felt little pain. When Asirpa reprimands him, Sugimoto concedes—war has changed him. The person he once was had been left behind on the battlefield. Some men, he says, can return to their old lives, but others like him remain stuck in the past. Asirpa, only twelve years old, considers …

Harmony In Transit:, Bridget Eddy

BYU Asian Studies Student Journal

Japan’s public transportation system is famous for its speed and efficiency. But it is more than just a way to travel. Trains and buses shape daily life and behavior in Japan. They reflect pertinent historical and cultural values, which provide a significant connection to society. Similar to sewing a new piece of fabric onto an old kimono, modern technology has become a part of the cultural garment–not a replacement for it–all while the existing fabric has continued to give it meaning and structure. The Japanese have woven older cultural threads into the new systems; concurrently and reflexively, the new technology …

The Second Great Reform:, Margaret Jeppesen

BYU Asian Studies Student Journal

Beginning in 1978 under Deng Xiaoping’s leadership, China launched the Great Economic Reform, also known as the Opening-up, as the nation transitioned from a centrally planned system to a market-oriented economy. In a single generation, millions were lifted out of poverty establishing China as a global economic superpower. Since then, China has placed great emphasis on maintaining a continuous economic upward trend and achieving technological self-sufficiency.

The development of artificial intelligence plays a prominent role in China’s second great reform to become a technological superpower. In 2017, President Xi Jinping introduced the New Generation Artificial Intelligence Development Plan (AIDP) —a …

Adapting Sherlock Holmes:, Victoria Ho

BYU Asian Studies Student Journal

Sherlock Holmes is one of the longest standing detectives in the world of crime and detective fiction, evident in the recreation of his character in various media. In Detective Conan, or Case Closed—a Japanese anime series adapted from a Japanese manga—the writer, Gosho Aoyama, creates his version of Sherlock Holmes in the form of Shinichi Kudo, a high school detective. However, parts of Holmes’s character can be problematic for Aoyama to adapt for Japanese society, particularly Holmes’s role as a disrupter of order. Thus, Aoyama provides a liminal space as a solution for Shinichi to preserve social order by turning …

A Macrocognitive Design Taxonomy For Simulation-Based Training Systems: Bridging Cognitive Theory And Human-Computer Interaction, Jessica M. Johnson

Virginia Digital Maritime Center (VDMC) Faculty Publications

Simulation-based training systems are increasingly deployed to prepare learners for complex, safety-critical, and dynamic work environments. While advances in computing have enabled immersive and data-rich simulations, many systems remain optimized for procedural accuracy and surface-level task performance rather than the macrocognitive processes that underpin adaptive expertise. Macrocognition encompasses higher-order cognitive processes that are essential for performance transfer beyond controlled training conditions. When these processes are insufficiently supported, training systems risk fostering brittle strategies and negative training effects. This paper introduces a macrocognitive design taxonomy for simulation-based training systems derived from a large-scale meta-analysis examining the transfer of macrocognitive skills from …

Hfpo-Da Aquatic Toxicity And Bioaccumulation, Bailey Dawn Rappold

Theses, Dissertations and Capstones

Per- and polyfluoroalkyl substances (PFAS) have been detected globally in environmental media and biota. Legacy compounds PFOA and PFOS have been observed to be toxic and bioaccumulative in low doses and have been removed from production and industrial processes. Replacement PFAS chemicals are less understood and present a gap in current knowledge in their toxicological effects. This research utilized extended chronic toxicity studies to assess the impacts of HFPO-DA, a short chain replacement PFAS, on the standard aquatic toxicology organism Pimephales promelas. Organisms were exposed for 29 to 30 days at environmentally relevant concentrations of the toxicant, 7.8125 ng/L …

Dnp Repository: Using Technology To Help Nurse Leaders Make A Global Impact, Cynthia Plonien, Cathy Brown, Vanessa Garrett

Nursing Faculty Publications & Presentations - Archive

No abstract provided.

Development And Validation Of An Analytical Method For Quantitative Determination Of Small Aldehydes In Plasma, Stephanie T. Clark

Chemistry & Biochemistry Theses - Archive

Small aldehydes such as formaldehyde and acetaldehyde are highly reactive metabolites that play important roles in biological processes related to oxidative stress, metabolism, and DNA damage. Because of their chemical reactivity, volatility, and low endogenous concentrations, accurate measurement of these compounds in biological samples remains analytically challenging. The goal was to develop and evaluate a practical analytical method for detecting small aldehydes in biologically relevant matrices using headspace gas chromatography mass spectrometry (HS-GC-MS). The method combined chemical derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and headspace sampling to stabilize aldehydes and enable selective detection by mass spectrometry. Method development focused on optimizing derivatization …

Understanding Student E-Textbook Satisfaction And Learning Outcomes: Does The Instructor Still Matter?, Qinyu Liao, Edith Galy, Lin Zhang, Xiaodi Zhou

Datasets

Background: With the increasing cost of textbooks and new generations of technology savvy students, universities and textbook publishers are promoting e-Textbooks as a more accessible and affordable alternative. Studies comparing adoption, preference, and learning effectiveness of print books and e-Textbooks provide conflicting results. There are a few research studies focused on student e-Textbook learning outcomes but no empirical studies have included the instructor as a factor.

Methods: This study proposes a holistic model to investigate the antecedents of college student e-Textbook satisfaction and learning outcomes. A survey of 261 college students investigating factors related to students, e-Textbook, and …

Havens For Corporate Lawbreaking, William J. Moon

Faculty Scholarship

Whether corporations are obligated to maximize profits or if they ought to consider societal interests more broadly remains one of the most highly contested debates in corporate law. Yet even the fiercest defenders of the firm’s profit motive concede that the corporation’s profit-seeking function cannot justify breaking the law. As a matter of American corporate law, directors and officers are in breach of their fiduciary duties if they facilitate or engage in profit-maximizing illegal activities. Or so we thought.

This Essay reveals a troubling trend of jurisdictions undercutting the legal compliance obligations of directors and officers. The current legal architecture …

Screen Scenes, Jordan Dewilde

Teaching Resource Archive

This elementary art lesson introduces students to Derrick Adams’s use of fragmentation to create abstract portraits and scenes from their own personal visual culture.

Students will brainstorm ideas of imagery that they frequently see in the media: TV, social media, YouTube, etc. Each student will choose an image to draw inside a corresponding frame (television set, tablet, phone, laptop screen, etc.), and apply Derrick Adams’s style of fragmentation and use of SMPTE color bars.

Development Of A Physiologically Based Pharmacokinetic (Pbpk) Simulation Model For Nicotine, Brian Kim, Sung Hun Bae, Mohamed Bashar, Bofang Yi, Mohammad Asikur Rahman, Prince Awuah, Matthew Hartog, Rony Panarsky, Tao Zhang

Pharmacy Faculty Scholarship

Tobacco is a major cause of chronic diseases such as lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease worldwide. Nicotine, the primary psychoactive component in tobacco, is highly addictive and while not the primary driver of such tobacco-related diseases, poses various health risks, particularly those affecting the cardiovascular and pulmonary systems. Although nicotine-based therapies, such as nicotine replacement products, are widely utilized in smoking cessation efforts today, the impact of newer, tobacco delivery systems such as electronic nicotine delivery systems, or ENDS, remains uncertain and warrants continued evaluation. This study aims to develop and validate a physiologically based pharmacokinetic …

Youth Aspirations And Migration: Challenges And Opportunities In Rural Dominican Republic, Truc T. Ngo

School of Engineering: Faculty Scholarship

The youth population plays a vital role in the continuing development of societies. However, young people in rural, underserved regions of the world face more life disadvantages compared to others due to lack of access and limited resources. Lower socioeconomic status, combined with poor living conditions, has caused young people to migrate out of their rural towns in early adulthood. Consequently, growth and development in rural communities face challenges due to a shortage of young, talented and skilled workforce. Through a survey, this study assesses youths' aspirations and perspectives towards future's prospects and out-migration from the rural town of El …

Monroe, New Hampshire Annual Report Of The Monroe Town Officers For The Year Ending December 31, 2025, Monroe Town Representatives

Monroe, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Notre Dame [Lawyer] Judge - 2026, Notre Dame Law School

Notre Dame Lawyer

Cover

25 U.S. Supreme Court Justice Amy Coney Barrett

31 The Rise of Chancellor Kathaleen McCormick

39 Justice Mbuyiseli Madlanga and the Pursuit of Justice

05 News

71 Alumni

81 Faculty

Judicial Profiles

35 Judge Ann Claire Williams ’75 J.D.

37 Q&A: Judge John Blakey ’88, ’92 J.D.

38 Judge Martha Vázquez ’75, ’78 J.D. ’43

43 Q&A: Judge Edward S. Kiel ’91 J.D.

45 Four Alumni: Their Roles as Federal Magistrate Judges

47 Judge Jerry Pappert ’88 J.D.

49 Justice Mary Yu ’93 J.D.

51 Judge Charles R. Wilson ’76, ’79 J.D.

53 The Specialists: Article I Federal Court …

Olli Spring 2026 Catalog, Toniann Leavitt

Osher Lifelong Learning Institute

No abstract provided.

Meta-Analysis: Diabetes Mellitus And The Risk Of Endometrial Cancer, Tricia Ho, Marika Ongpauco, Han Ha Ngoc Nguyen

Physician Assistant Studies | Graduate Research Papers

Background: Many studies have looked at the relationship between diabetes mellitus and development of endometrial cancer. This study provides an updated systematic review and meta-analysis of the estimated effect of diabetes and the risk of endometrial cancer.

Methods: Some studies were found on databases such as PubMed and Iceberg. The remaining studies were extracted from the initial studies found. Binary data was collected and the raw data was imputed into a Fixed Effects Model.

Results: A total of 25 studies were included in this meta-analysis, generating statistically significant results (p < 0.001, OR 2.05, 95% Cl 1.92-2.19).

Discussion: Diabetes is found to be …

The Effects Of Antidepressant Medications On Sleep Quality In Dominican University Of California Students, Natalie L. Davis, Kenna Wohlford, Stephanie Lee

Physician Assistant Studies | Graduate Research Papers

We spend approximately one third of our life time sleeping or attempting to sleep. The quality of our sleep is equally, if not more important than the amount of sleep we get. This study assesses the effects that medications, specifically antidepressants, can have on sleep quality in Dominican University of California students. 118 participants completed a Qualtrics survey including questions regarding stress, sleep quality, medication lists, and demographics. This study utilized the Pittsburgh Sleep Quality Index (PSQI) to quantify participants’ sleep quality as the outcome. Participant stress levels were assessed with a Likert scale question asking for stress levels on …

Cpaf In Focus Vol. 11 One On One : Reflections On Change And Impact, Michiko Karissa M. Buot, Johnnelda P. Cosep, Paulo C. Aquino, Therese Marie L. Quilnat, V. Bruce J. Tolentino, Agustin L. Arcenas, Samantha Geraldine G. De Los Santos, Guinevere T. Madlangbayan, Raizza F. Acuzar

IN FOCUS: Development & Governance

This volume of In Focus invites its readers to have a one-on-one with stories exploring how small acts of change can grow into waves of impact in governance and development -- From alumni who continue to excel beyond the university, to students recognized for academic achievements, to field notes from our research centers that ground theory in practice. We will also feature reflective think pieces from experts in governance and development, alongside an infographic highlighting the recently concluded ICGD4. At its core, the magazine asks its readers to reflect: how can individual acts of change create lasting impact? 

Editorial Team …

Annual Report Of Town Officials, Departments, And Committees, Town Of Acworth, New Hampshire For The Year Ending December 31, 2025, Acworth Town Representatives

Acworth, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

How Elementary School Principals Equitably Support Mexican Indigenous Students Using The Cultural Proficiency Essential Elements, Veronica Hernandez

Dissertations

Purpose: The purpose of this qualitative study was to identify and describe how elementary principals used the essential elements of cultural proficiency (i.e., assessing culture, valuing diversity, managing the dynamics of difference, adapting to diversity, and institutionalizing cultural knowledge) to provide equitable access for Mexican Indigenous students in California. A second purpose was to identify what elementary principals recommended as best practices for implementing the essential elements of cultural proficiency. Methodology: This ethnographic qualitative research study utilized the elements of cultural proficiency to identify and describe the practices of California elementary school principals in equitably supporting Mexican Indigenous students. Using …

The Culturally Intelligent Higher Education Leader: Leadership Strategies Of Exemplary California Community College Mid-Level Student Services Administrators In Creating A Culture Of Inclusiveness, Marisol Alaniz

Dissertations

Purpose: It is the purpose of this sequential explanatory mixed-method study to identify and describe the leadership strategies that exemplary mid-level student services administrators in California Community Colleges use to create an organizational culture of inclusiveness using Kennedy’s (2008) five leadership qualities.

Methodology: For this study, a sequential explanatory mixed-methods design was used. The study’s quantitative part was conducted using an online survey instrument delivered to each participant. In the survey, participants were asked whether they were willing to take part in a one-to-one follow-up interview. Once identified, qualitative research was used to conduct interviews with exemplary mid-level student services …