Digital Commons Network^™

Applications And Challenges Of Utilizing Digital Pathology And Ai-Enabled Workflows In Clinical Trials, Manu Sebastian, Harsh Batra, Monika Lamba Saini, Staci Kearney, Lorcan Sherry, Serge Alexanian, Michael Cohen, William Weber, Joe Lennerz, Anil V Parwani

Faculty, Staff and Student Publications

This is a comprehensive review on current utilization and challenges of digital pathology adoption in clinical trials and aims to provide a broad view on its impact on pathology review processes in clinical trials. It provides an overview of current pathology review practices in clinical trials and unique advantages digital pathology adoption can offer. The key areas including existing workflows, use case scenarios in different disease areas in clinical trials, including but not limited to patient identification and pre-screening, and regulatory aspects have been described with relevance. In addition, the review delves into the integration of genomics, AI, image analysis, …

Infliximab For Grade Iii Or Iv Immune Checkpoint Inhibitor Nephritis Clinical And Translational Evidence, Nada Youssef, Masroor Habeeb, Hong Chen, Zainab Alhamal, Omar Mamlouk, Heather Lin, Valda Page, Amanda Tchakarov, Sreyashi Basu, Adi Diab, Padmanee Sharma, Ala Abudayyeh

Faculty, Staff and Student Publications

Introduction: Acute interstitial nephritis (AIN) is a common presentation of immune checkpoint inhibitor (ICI) toxicity. Increased tumor necrosis factor (TNF)-α expression has been observed in ICI-induced AIN (ICI-AIN). In this study, we compared treatment with glucocorticoids plus infliximab to glucocorticoids only in stage III or IV ICI-AIN. We conducted retrospective NanoString analysis of ICI-exposed kidney samples to identify associated gene signatures and possible association with TNF-α expression.

Methods: We reviewed the records of patients who received ICI, developed acute kidney injury (AKI), and underwent kidney biopsy at MD Anderson Cancer Center from January 2022 to October 2024. Fifty-five patients had …

Reconsidering The Definition Of Triple-Negative Breast Cancer In The Immune Checkpoint Inhibitor Era: An Optimal Cut-Off Value For Hormone Receptor Percentage Of Her2-Negative Invasive Breast Cancer, Takeo Fujii, Toshiaki Iwase, Yu Shen, Jami Fukui, Naoto T Ueno

Faculty, Staff and Student Publications

The optimal cut-off values of estrogen receptor (ER) and progesterone receptor (PgR) expression to define the positivity of ER and PgR have been under discussion for over a decade but remain controversial. The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) and the St. Gallen International Expert Consensus recommended that breast cancers with ≥1% of ER or PgR expression should be considered hormone receptor (HR)-positive tumors but ER/PR expression of 1% to 10% should be reported as HR-low positive; however, among HER2-negative disease, data on the overall benefit of adjuvant endocrine therapies for patients with HR-low positive disease is …

T Cells Modulate The Development And Maintenance Of Painful Paclitaxel-Induced Peripheral Neuropathy In Rnu Rats, Ahmed Olalekan Bakare, Gerard Limerick, Vasudha Goel, Ratan K Banik, Lei Zheng, Andrew J Shepherd, Kristine Glunde, Qin Zheng, Eellan Sivanesan

Faculty, Staff and Student Publications

The role of T cells in chemotherapy-induced peripheral neuropathy (CIPN) is complex and shaped by biological and experimental factors, including sex, hormonal status, genetic background, and cancer model. This complexity has contributed to inconsistent findings among studies, limiting therapeutic progress. In this study, we investigate how T cells contribute to painful paclitaxel (PTX)-induced peripheral neuropathy (PIPN). Adult male T cell-competent (RNU+/−) and T cell-deficient (RNU−/−) rats were subcutaneously inoculated with tumor cells and subsequently treated with intraperitoneal PTX (8 mg/kg total dose). Reflexive (mechanical, heat, cold) and non-reflexive (burrowing, gait) pain behaviors were assessed from baseline through week 6. Immunohistochemistry …

Protective Behavioral Strategies On Alcohol And Cannabis Co-Use Occasions, Sabrina Todaro

Open Access Dissertations

Simultaneous use of alcohol and cannabis, or co-use (i.e., the use of both substances so that effects overlap), is an increasingly significant public health concern among young adults between the ages of 18 and 25 in the U.S. (SAMHSA 2025; Terry-McElrath & Patrick, 2018). Protective behavioral strategies (PBS; i.e., tactics used to modify or limit substance use related harm; Pearson, 2013) have been robustly linked to fewer negative outcomes (e.g., lower use quantity, frequency, and consequences) for alcohol- and cannabis-only occasions (Bravo et al., 2016; Bravo et al., 2017; Bravo et al., 2019; Pearson, 2013; Pedersen et al., 2016; Pedersen …

The Influence Of Limb Dominance On Neural Activation Patterns While Performing Different Motor Control Tasks, Kevin A. Hooks

Graduate Studies Theses and Dissertations 2026

Humans interact with our environment in many ways. One of the most outward-facing aspects of this is limb dominance. The neural underpinnings of limb dominance remain in question today. The objective of this research was to use different methods to analyze neural activation while subjects performed upper extremity motor tasks while recording electroencephalography (EEG). The first experiment used decoding methods to examine whether neural signals collected from the contralateral limb could be used to train a classifier to test on the ipsilateral limb during a reach-to-grasp or reach-to-touch task. It was determined above chance level that within-subject action and direction …

An Experimental Investigation On The Influence Of Emotion On Craving And Alcohol Consumption Among Women, Melissa C. Rothstein

Open Access Dissertations

A burgeoning literature suggests that alcohol use, rates of binge drinking, rates of alcohol use disorder, and experiences of alcohol-related consequences are increasing among women in comparison to men (Adams et al., 2022; Baraona et al., 1991; Peltier et al., 2019; White, 2020). As such, alcohol use among women is a growing public health concern, but historically, most existing research, including interventions, has focused on men (Agabio et al., 2017; Holzhauer et al., 2020; Maxwell et al., 2022; Verplaetse et al., 2021; White, 2020). Although there is a large literature on the role of negative emotion in alcohol use (Austin …

Cultivating Workplace Happiness In Technology Workers, Cherie A. Herrin

Graduate Studies Theses and Dissertations 2026

Technology workers are central to the innovation and performance of modern organizations and retaining them is a persistent challenge for modern organizations. One important aspect of retention in many contexts is Workplace Happiness, which has been argued to improve worker performance and reduce turnover; however, there is little empirical evidence of the effectiveness of these interventions for technology workers. This dissertation develops a model in which two affective states, Workplace Happiness and Workplace Distress, mediate the relationships between six socio-technical work conditions and two behavioral outcomes: Turnover Intent and Work Execution (i.e., self-rated work performance and quality). A systematic literature …

Optimizing Markov Chain Monte Carlo Algorithms For Fairness, Scalability, And Interpretability In Electoral Redistricting, Madhukara Kekulandara

Open Access Dissertations

Gerrymandering undermines democratic representation by manipulating electoral district boundaries to dilute the political influence of targeted communities. While Markov Chain Monte Carlo (MCMC) based redistricting algorithms have become a standard computational tool for detecting partisan gerrymandering, their effectiveness in addressing racial gerrymandering and their scalability on modern computing systems remain limited. This dissertation advances the theory and practice of algorithmic redistricting by optimizing MCMC-based approaches across three dimensions: racial fairness, computational efficiency, and interpretability.

First, this work introduces the Partial Map MCMC algorithm, a novel redistricting method designed specifically to address racial gerrymandering under the legal framework of Section 2 …

Integrated Corridor Management Framework For Severe Freeway Incidents, Sanjida Afroz Iqra

Graduate Studies Theses and Dissertations 2026

Traffic incidents are a major source of non-recurrent congestion on urban freeways, generating substantial mobility, safety, and economic impacts. Severe incidents that block multiple or all travel lanes are particularly disruptive because they degrade freeway operations and propagate congestion onto surrounding arterials. Effective Integrated Corridor Management (ICM) requires the ability to identify severe incidents, estimate their network-wide impacts, and anticipate the traffic conditions and driver behaviors that contribute to instability. This dissertation develops a data-driven ICM framework to address these challenges using real-world incident, crash, detector, and connected vehicle data from major Central Florida corridors, including I-4 and SR-417. The …

Investigating The Anti-Apoptotic Properties Of The N-Terminus Of The Chlamydia Trachomatis Effector Tarp, Kasey S. Jordan

Graduate Studies Theses and Dissertations 2026

As the most prevalent bacterial STI in the United States and leading cause of infection-related blindness worldwide, the obligate intracellular bacteria, Chlamydia trachomatis (Ct), poses a significant threat to public health. As an obligate intracellular bacteria, invasion of the host cell is a crucial step in Chlamydia’s developmental cycle. To drive invasion, Ct injects prepackaged effectors into the host cell using a T3SS. An early Chlamydial effector, translocated actin recruiting phosphoprotein, or Tarp, interacts with host cell actin to promote invasion, mediated via Tarp’s C-terminal region. Although the function of Tarp’s C-terminus is well defined, the Tarp’s N-terminus …

Homoplasy Of Maxillary Orthognathism In Derived Homo, Jared Jordan

Graduate Studies Theses and Dissertations 2026

The evolution of the orthognathic condition in the genus Homo represents a monumental transition toward the facial morphology of modern humans from that of earlier hominins, but the phylogenetic positioning of this transformation remains poorly understood. This study investigated temporal trends in maxillary and mandibular prognathism in the genus Homo, and whether maxillary and mandibular shortening in East Asian H. erectus and later East Asian Middle Pleistocene Homo (e.g., Homo longi) represent independent derivations of orthognathic morphology, thereby making orthognathism a homoplasy in the genus Homo. Using a sample of roughly 109 cranial and mandibular specimens spanning …

En Tiempos De Extinción, Adialyz Del Valle Berríos

Graduate Studies Theses and Dissertations 2026

En Tiempos de Extinción is a collection of short, mostly speculative, stories exploring themes of community, exploitation, resistance, and the ever-present effects of colonialism in nearly every aspect of life. “El Amor de una Diosa es Amor Suficiente” centers on a young girl’s initiation into a community that will do whatever it takes to indoctrinate the young. “Al Aire Libre” focuses on two tenured professors determined to enjoy their last day on the job, navigating the complicated feelings of what progress means in a world that prioritizes capital. In “OVNI,” the history of a wacky television dating show unravels …

Examining Teachers’ Data Usage Using The Teacher Data Use Survey, Natasha L. Hawkins

Graduate Studies Theses and Dissertations 2026

The United States spends approximately 2.7 billion dollars on classroom assessments and local exams for K-12 students (SIMBA, 2019).  However, despite this financial investment and the adoption of data-driven frameworks such as Multi-Tiered System of Support, the U.S. Department of Education found that only 55% of teachers used student data to make instructional decisions (U.S. Department of Education, 2007).  This study aims to explore the psychological and organizational factors that influence teachers’ data use when making instructional decisions.

This study used the Teacher Data Use Survey (TDUS) to investigate the extent that teachers’ use of data could be predicted by …

A New Functional Setting For Term Structure Modeling Using The Health-Jarrow-Morton Framework, Michael Pokojovy, Ebenezer Nkum, Thomas M. Fullerton Jr.

Mathematics & Statistics Faculty Publications

The well-known Heath–Jarrow–Morton (HJM) framework provides a universal and efficacious instrument for modeling the stochastic evolution of an entire yield curve by explaining the interest rate dynamics in continuous time under no-arbitrage conditions. Existing implementations involve exponentially weighted function spaces as theoretical settings for the former stochastic evolution. While the choice of weight can have a drastic effect on model calibration and subsequent forecasting, it cannot be estimated from market data and does not allow for any objective interpretation. The proposed approach does not have this shortcoming as it adopts a suitably designed unweighted function space. The HJM equation is …

Multi-Grade Deep Learning, Yuesheng Xu

Mathematics & Statistics Faculty Publications

Deep learning requires solving a nonconvex optimization problem of a large size to learn a deep neural network (DNN). The current deep learning model is of a single-grade, that is, it trains a DNN end-to-end, by solving a single nonconvex optimization problem. When the layer number of the neural network is large, it is computationally challenging to carry out such a task efficiently. The complexity of the task comes from learning all weight matrices and bias vectors from one single nonconvex optimization problem of a large size. Inspired by the human education process which arranges learning in grades, we …

Mg-Spair: Multi-Grade Sparse-Guided Implicit Representation For Training-Data-Free Image Restoration, Jianmin Liao, Lei Huang, Ronglong Fang, Ashley Prater-Bennette, Lixin Shen, Yuesheng Xu

Mathematics & Statistics Faculty Publications

MG-SpaIR is a training-data-free framework for restoring a clean image from a single observation corrupted by a mixture of blur, downsampling, noise, and missing pixels. Building on implicit neural representations (INRs), we introduce a multi-grade residual hierarchy that progressively refines the reconstruction from low to high spatial frequencies across grades, improving representational fidelity and mitigating spectral limitations. To stabilize reconstruction optimization and suppress INR-induced artifacts, we further propose an explicit sparse proximal regularization (e.g., ℓ0 type) applied directly in the high-resolution image domain, which discourages spurious high-frequency patterns while preserving sharp structures. The resulting optimization is solved efficiently via a …

Evaluating Novel Targeted Combination Therapies For Gastrointestinal Cancers, Joseph A. Goode

Graduate Studies Theses and Dissertations 2026

Gastrointestinal (GI) cancers remain among the leading causes of cancer-related mortality worldwide, with therapeutic resistance continuing to limit the effectiveness of current treatments. Three complementary studies were conducted to identify therapeutic vulnerabilities and evaluate novel combination strategies in pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC).  First, dual inhibition of fibroblast growth factor receptor 4 (FGFR4) and phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling was investigated in PDAC models. A combination of targeted drug treatments reduced viability, clonogenic survival, migration, and suppressed signaling pathways involved in translational control. This supported a functional interaction between FGFR4 and PI3K-mTOR co-activation in …

Investigating The Impact Of School Leaders’ Leadership Style And Teachers’ Intrinsic Motivation For Improved Science Instruction In Elementary Schools, Leila M. Greene

Graduate Studies Theses and Dissertations 2026

A report by the National Academies of Sciences, Engineering, and Medicine, determined that 69% of U.S. elementary teachers are not prepared to teach science, especially in the areas of earth/space and physical sciences. As a result, some elementary teachers avoid teaching science. School administrators play a key role in providing a supportive environment to inspire and motivate elementary science teachers. For this reason, the study utilized the Self-Determination Theory (SDT), to examine three types of school leadership styles (Transformational, Transactional, and Laissez-Faire) and how they impact the intrinsic motivation for elementary science teachers in three areas including autonomy, competency, and …

Deciphering Ultrafast Photoinduced And Photocatalytic Reaction Dynamics On Oxide Surfaces: Direct Detection Of Radical Intermediates, Fragment Trapping, And Carbon–Carbon, Carbon–Oxygen, And Carbon–Hydrogen Bond Formation Pathways, Aakash Gupta

Graduate Studies Theses and Dissertations 2026

Understanding photoinduced reactions at solid interfaces is essential for advancing heterogeneous photocatalysis, surface photochemistry, and energy conversion technologies. This dissertation investigates the ultrafast dynamics of reactive intermediates, fragment trapping, and radical-mediated bond formation on oxide surfaces using time-of-flight mass spectrometry in conjunction with femtosecond pump-probe spectroscopy. Various experimental findings are validated through collaborations via density functional theory (DFT). By combining temporal, mass, and energy-resolved measurements, this work provides molecular-level insight into the elementary processes governing light-driven surface reactions. The photodissociation dynamics of CH₃I adsorbed on TiO₂(110), TiO₂(100), and amorphous silicon oxide surfaces are examined …

Minimizing Performance Overheads For Crash-Consistency In Disaggregated Persistent Memory, Khan Shaikhul Hadi

Graduate Studies Theses and Dissertations 2026

Compute express link (CXL) enables persistent memory disaggregation with memory pooling and hardware managed multi-host memory sharing capability, resulting in better resource utilization, increased scalability. Persistency-aware applications need to manage crash consistency across the system which results in significant performance overhead. This dissertation systematically investigates performance overhead to achieve crash consistency in disaggregated persistent memory and proposes solutions to enable persistency-aware application scaling for distributed system. First, we study persistent parallel programming to scale computation capability beyond single processor and determine the underlying hardware limitation to adopt lock-free data structure. We propose hardware support to design durable atomic instruction (DAI) …

Coached By A Custom Chatgpt And Ready For Trial, Staci J. Pratt

Publications

No abstract provided.

The Role Of Kindergartens In Promoting Educational Moral Values In Children Through Storytelling, Reem Al-Hajj, Marwan Abu-Alrob, Osama Tawfeeq Jarrar

Australian Journal of Teacher Education

This study examines the role of kindergartens in promoting educational moral values in children through storytelling. The research employs a quantitative approach with questionnaires as a study tool. The study sample, selected randomly, consists of 135 kindergarten teachers from Jenin Directorate, Palestine, analyzed using Structural Equation Modeling (Smart-PLS4). The results show that kindergartens have a significant role in fostering educational moral values through storytelling, supported by strong path coefficients (e.g., β = 0.361, p = 0.002 for proposed suggestions) and a high explained variance (R² = 0.673). This framework, which positions children as active meaning-makers rather than passive recipients of …

Framings Of Intercultural Competence In Australian Teacher Education: Conceptual Bases And Implications, James F. Toohey, Michael D. Carey, Peter R. Grainger

Australian Journal of Teacher Education

Developing an interculturally competent teaching workforce remains an ongoing priority in Australia, yet preparation practices vary in their conceptual grounding. This theoretical paper examines four broad paradigmatic framings that inform strategies to develop intercultural competence in preservice teachers: cognitive, dispositional, critical, and linguistic. We analyse how each paradigm foregrounds particular assumptions about culture, communication, and development, and consider the implications of their partial application in teacher education. Rather than positioning these paradigms as competing models, the paper argues that they function as complementary lenses through which intercultural preparation can be understood and refined. Particular attention is given to the linguistic …

Research-Based Learning For Pre-Service Teachers’ Meta-Reflexivity: Insights From English Language Teacher Education In Türkiye, İrem Çomoğlu, Eda Ceylan, Eda Akgün-Özpolat, Kenan Dikilitaş

Australian Journal of Teacher Education

Drawing on Cramer et al.’s (2023) framework for meta-reflexive teacher education, we conducted a case study to examine how research-based learning (RbL) helps pre-service teachers (PSTs) develop meta-reflexivity. The data was collected in an undergraduate course in Türkiye where 81 PSTs engaged in RbL through developing, explaining, and exploring their pedagogical puzzles (PPs). Analysis of data from written reflections and class recordings generated themes indicating that PSTs began to adopt a meta-reflexive stance through a set of research and reflection practices involved in their puzzle exploration processes. The study suggests that RbL may be a promising approach for fostering PSTs’ …

An Examination Of The Determinants Of Audit Quality: Implications From Firms Listed In Us Stock Markets, Abdelrahman Naser Elmaria

Theses and Dissertations

The purpose of this thesis is to examine the effect of several audit determinants, namely audit tenure, non-audit to audit fees ratio, auditing firm size, and firm size, impact on audit quality. This thesis extends the existing literature on audit determinants effect on audit quality using a Generalized Linear Model, (GLM) regression with robust estimation by analyzing a sample of 446 companies from the USA in the manufacture and service sectors. This is conducted through a series of diagnostic tests to identify an appropriate regression model. Such tests include testing and checking of baseline regression models to check for multicollinearity, …

Exploring Technology Supporting Explicit Teaching And Learning Of Educator Skills And Knowledge: An Ipa Study, Renee Crawford

Australian Journal of Teacher Education

Teacher shortages and increasing accountability measures have placed pressure on initial teacher education (ITE) programs to demonstrate their impact on graduate readiness. This study aimed to explore how technology can support explicit teaching and learning of educator skills and knowledge within a constructivist blended learning framework. Using an interpretative phenomenological analysis (IPA) approach, the research examined preservice teachers’ (PSTs) perceptions and experiences during and after completing an ITE secondary music methods unit where the approach was implemented and modelled. Results indicate that making pedagogy visible through technology enhanced strategies provided PSTs with opportunities to develop critical skills and knowledge aligned …

Initial Teacher Education For Inclusion: Does Practicum Bring Pre-Service Teachers Closer To An Inclusive Approach?, Constanza Herrera-Seda, Constanza Cárdenas Alarcón, Carlos Vanegas-Ortega

Australian Journal of Teacher Education

Practicum is considered an essential element of initial teacher education for inclusive education. In this article, we explore its contribution to the pre-service teachers' adoption of an inclusive approach. We conducted a qualitative, multicase study of three primary teacher education programmes in Chile. Through episodic interviews, we produced data from 18 pre-service teachers. The main results showed that practicum causes various emotions, cognitions, and actions that interact with the adoption of an inclusive approach. Overwhelming pre-service teachers’ emotions related to exclusion can undermine their self-efficacy, leading them to avoid an inclusive approach. Also, the practicum tends to reproduce deficit- …

Pre-Service Teachers’ Self-Perceptions Of Relationship Skills For Future Work In Schools, Melissa Newberry, Elizabeth B. Hinchcliff, Chelsea Cole, Michael Richardson

Australian Journal of Teacher Education

This study focuses on the perceptions pre-service teachers hold about their own abilities to form relationships with four stakeholders of schools: students, parents, teachers and administrators. Survey data from 257 students enrolled in teacher preparation programs in a mid-sized, private university in the Western US were collected, including their beliefs about relationship skills, experience with children/youth, and conceptions of relationship formation as practicing teachers. Results indicate high confidence in relationship skills, yet few ideas on how to translate those into action when it comes to forming professional relationships. These findings suggest that pre-service teachers may be underprepared regarding the relational …

Investigating The Changes In Attitudes Towards Science Among Pre-Service Elementary Teachers Enrolled In A Science Methods Course Using A New Version Of The Test Of Science Related Attitudes, Christopher S. Long, Becky Sinclair

Australian Journal of Teacher Education

This article examines the changes in student attitudes towards science among pre-service elementary teachers (PSETs), who were enrolled in a science methods course at a large public university in Texas, USA. A new version of the Test of Science Related Attitudes (TOSRA) called TOSRA-3 was used to measure six dimensions of attitudes towards science. TOSRA-3 was created in an effort to create a more economical, 35 items versus 70 items, version of the original TOSRA. TOSRA-3 was found to be valid and reliable for use with PSETs. Factor analysis suggests a six scale structure with a Cronbach’s Alpha for each …