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Articles 101071 - 101100 of 5150693
Full-Text Articles in Entire DC Network
Neuroattnfusenet Dual Branch Attention Fusion For Brain Tumor Mri Classification, Md Sanowar Hossain Sabuj, Farzana Sultana, Md Hasan Or Rashid, Rahul Mudhiraj Mullela
Neuroattnfusenet Dual Branch Attention Fusion For Brain Tumor Mri Classification, Md Sanowar Hossain Sabuj, Farzana Sultana, Md Hasan Or Rashid, Rahul Mudhiraj Mullela
Student Publications
Brain tumor MRI classification remains challenging because tumor appearance varies across cases, class boundaries can be visually subtle, and public 2D MRI datasets may contain redundancy or source-specific biases that inflate reported performance. This study proposes NeuroAttnFuseNet, a dual-path attention-guided fusion network for four-class MRI image classification into glioma, meningioma, pituitary, and no tumor. The model combines a Swin-T branch for hierarchical local morphological representation with a frozen DINOv2 ViT-B/14 branch that provides a 768-dimensional global descriptor from the [CLS] token. The Swin and DINOv2 features are concatenated and passed through a channel-attention gate and fusion MLP before final softmax …
Languages Of Marginalization: Educational Inequality And Identity Formation Among Rohingya Refugees In Bangladesh, Md Khalid Rahman
Languages Of Marginalization: Educational Inequality And Identity Formation Among Rohingya Refugees In Bangladesh, Md Khalid Rahman
Sustainability and Social Justice
This research paper investigates how language-of-instruction policies shape educational inequality and identity formation among Rohingya refugee children living in protracted displacement in Cox’ Bazar, Bangladesh. Analyzed from a human right–based framework, the study examines whether existing educational policies align with international legal standards on the right to education, including the UDHR, ICESCR, Child Convention and SDG 4. While these frameworks guarantee non-discriminatory and inclusive access to education, the reality in Cox’s Bazar reveals a persistent gap between normative commitments and policy implementation. Moreover, the study explores how the exclusion of both the host language (Bangla) and the native Rohingya language …
Failure Rates And Patient-Reported Outcomes Are Similar Across 5 Arthroscopic, Suprapectoral Biceps Tenodesis Fixation Techniques, Senah E. Stephens, Samantha M. Strohm, Rachael M. Shaughnessy, Katherine S. Worcester, Kevin F. Bonner
Failure Rates And Patient-Reported Outcomes Are Similar Across 5 Arthroscopic, Suprapectoral Biceps Tenodesis Fixation Techniques, Senah E. Stephens, Samantha M. Strohm, Rachael M. Shaughnessy, Katherine S. Worcester, Kevin F. Bonner
Department Surgery Faculty Publications
Purpose
To compare failure rates and patient-reported outcome measures (PROMs) across 5 arthroscopic, suprapectoral biceps tenodesis fixation techniques: tenodesis screw, tenodesis anchor, expanding tenodesis anchor, onlay with single all-suture anchor, and soft tissue tenodesis in the bicipital groove with suture.
Methods
This was a retrospective cohort study approved by the Institutional Review Board, including patients age 18 years or older who underwent arthroscopic, suprapectoral biceps tenodesis between 2014 and 2024 with a minimum of 6 months of clinical follow-up. Exclusion criteria included cervical pathology, chronic pain syndromes, revisions, and workers' compensation cases. Patients completed PROMs including pain Visual Analog Scale …
Examining Challenges For Sociology Master’S Degree Students At California State University, David Ortuno
Examining Challenges For Sociology Master’S Degree Students At California State University, David Ortuno
University of the Pacific Theses and Dissertations
The purpose of this study is to identify the lived experiences of CSU sociology graduate students pursuing a master’s degree. Seven sociology graduate students from six of the eight (75%) total sociology MA programs throughout the entire CSU system were interviewed. Their responses were designed to analyze the support systems and challenges they face while pursuing a master's degree, as well as to investigate whether their experiences correlate with or fail to correlate with the promises in the CSU mission statement, and to answer the study’s research questions and achieve the purpose of this qualitative study.
Four themes emerged from …
Investigating The Potential Neurotoxic Effects Of Cell-Free Factors By Batrachochytrium Dendrobatidis On Locomotion In Xenopus Laevis, Anna Lennon, Laura K. Reinert, Louise A. Rollins-Smith, Will Best, Chase T. Kinsey Phd
Investigating The Potential Neurotoxic Effects Of Cell-Free Factors By Batrachochytrium Dendrobatidis On Locomotion In Xenopus Laevis, Anna Lennon, Laura K. Reinert, Louise A. Rollins-Smith, Will Best, Chase T. Kinsey Phd
Funded Scholarship
Chytridiomycosis is a contributor to amphibian population declines. Diseased amphibians show symptoms of lethargy and loss of righting reflexes, likely due to ion imbalance across the skin. However, it is possible developing zoosporangia release toxins that affect neuromuscular activity. Using Xenopus laevis as a model, we hypothesized that locomotor performance would be affected by injection of Bd supernatant factors. X. laevis were injected and then filmed performing a swimming escape response with high-speed cameras at 4 hours, 24 hours, and 1- week post-injection. Average maximum swimming velocity and escape latency were digitized using high speed video. Despite no difference in …
The Impact Of Remittances On Food Security In Times Of Crisis—Evidence From Covid-19 In Latin America And The Caribbean, Colin Cannonier
The Impact Of Remittances On Food Security In Times Of Crisis—Evidence From Covid-19 In Latin America And The Caribbean, Colin Cannonier
Funded Scholarship
This study examines the association between workers’ remittances and food insecurity in Latin America and the Caribbean using data from a Coronavirus survey covering over 100,000 individuals during the COVID-19 pandemic. Results indicate that receipt of remittances is associated with an 8.8% decrease (2.5% points) in overall food insecurity. Heterogeneous effects are observed among females, individuals in Latin America, and households with children. Remittances from the USA exhibit a stronger influence on reducing food insecurity. The findings underscore the potential importance of remittances in improving food security at both extensive and intensive margins. Policy issues are also discussed.
Correlates Of Recovery Capital Among Women In Jails: Leveraging A Dimensional Recovery Framework, Amanda Fallin-Bennett, Martha Tillson, Jaxin Annett, Hartley Feld, Michele Staton
Correlates Of Recovery Capital Among Women In Jails: Leveraging A Dimensional Recovery Framework, Amanda Fallin-Bennett, Martha Tillson, Jaxin Annett, Hartley Feld, Michele Staton
Nursing Faculty Publications
Background: Recovery capital encompasses internal and external factors that support recovery from substance use disorder, such as employment, social support, and physical and mental health. There is a need for more research on recovery capital among women who are incarcerated, who often face complex barriers to recovery, such as poverty, unemployment, and histories of trauma.
Methods: Women (N ¼ 900) were recruited from Kentucky jails as part of the broader NIDA-funded Kentucky Justice Community Opioid Innovation Network (JCOIN) cooperative project. Measures from baseline interviews (during incarceration) were selected in alignment with the Substance Abuse Mental Health Service Administration (SAMHSA)’s four …
“Being Treated As The Expert:” A Blueprint For A Community Advisory Board Approach To Elevate The Voice Of People With Living Experience With Substance Use In Academic Research, Trevor Moffitt, Survivors Union Of The Bluegrass, Bryson Henson, April M. Young, Sharon L. Walsh, Rachel Vickers-Smith, Junior Cruz, Jeremy Byard, Brook West, Amanda Fallin-Bennett
“Being Treated As The Expert:” A Blueprint For A Community Advisory Board Approach To Elevate The Voice Of People With Living Experience With Substance Use In Academic Research, Trevor Moffitt, Survivors Union Of The Bluegrass, Bryson Henson, April M. Young, Sharon L. Walsh, Rachel Vickers-Smith, Junior Cruz, Jeremy Byard, Brook West, Amanda Fallin-Bennett
Nursing Faculty Publications
Introduction: Researchers have traditionally engaged Community Advisory Boards (CABs) to meaningfully involve community members in the research process. However, CABs are often formed only after a grant is funded, leading to criticisms of functioning merely as “ethical approvers.” For substance use researchers, the inclusion of people with living experience (PWLE; current experience with drug use) across all stages of research is especially important as they have historically been the experts in the needs of their community. Methods: In response to this need for community engagement in research, the University of Kentucky, in partnership with a local recovery community center (RCC; …
Coalition Building And Citizen Science For Radon Risk Reduction, Stacy Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, David Gross, Caitlyn Curtis, Amanda Thaxton-Wiggins, Mary Kay Rayens, Ellen J. Hahn
Coalition Building And Citizen Science For Radon Risk Reduction, Stacy Stanifer, Kathy Rademacher, Whitney Sedio, Naomi Cheek, David Gross, Caitlyn Curtis, Amanda Thaxton-Wiggins, Mary Kay Rayens, Ellen J. Hahn
Nursing Faculty Publications
We evaluated the implementation of local coalitions led in partnership with citizen scientists, community-based organizations, and public libraries in four rural communities to lower exposure to radon in the home. The objectives were to (1) describe the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) of four radon coalitions, and (2) compare RE-AIM factors among citizen scientists who participated in the coalitions and those who did not. A larger community-engaged research project embedded coalition building using a citizen science approach. Three of the four coalitions focused on health and wellness more broadly (18–34 members); one focused solely on radon (10 members). Coalition membership and activities varied …
Evaluation Of A Tobacco Treatment Specialist Training Program Targeted To Behavioral Health Professionals, Chizimuzo T. C. Okoli, Sarret Seng, Bassema Abu Farsakh, Emily Koyagi, Heather Beck, Audrey Darville
Evaluation Of A Tobacco Treatment Specialist Training Program Targeted To Behavioral Health Professionals, Chizimuzo T. C. Okoli, Sarret Seng, Bassema Abu Farsakh, Emily Koyagi, Heather Beck, Audrey Darville
Nursing Faculty Publications
Tobacco use remains disproportionately high among adults living with mental illnesses (MIs), contributing to excess morbidity and mortality, particularly in high-burden states such as Kentucky. Behavioral healthcare providers are well-positioned to address this disparity but often lack formal training in evidence-based tobacco treatment. Tobacco Treatment Specialist (TTS) training provides healthcare providers with skills to deliver evidence-based tobacco treatment; however, traditional TTS training models often rely on synchronous, in-person or live virtual formats, which may limit accessibility for some healthcare workforces. Asynchronous, web-based delivery models may reduce these barriers. This study evaluates a targeted, asynchronous TTS training program designed for providers …
Financial Status, Fatalism, And Self-Care Of Cardiovascular Disease Risk Factors Among Rural Adults Living In Socioeconomically Distressed Areas, Ashmita Thapa, Geunyeong Cha, Dustin Hodges, Jia-Rong Wu, Misook L. Chung, Martha J. Biddle, Jennifer L. Smith, Debra K. Moser
Financial Status, Fatalism, And Self-Care Of Cardiovascular Disease Risk Factors Among Rural Adults Living In Socioeconomically Distressed Areas, Ashmita Thapa, Geunyeong Cha, Dustin Hodges, Jia-Rong Wu, Misook L. Chung, Martha J. Biddle, Jennifer L. Smith, Debra K. Moser
Nursing Faculty Publications
Purpose: Adults with fewer financial resources often have poor self-care. Rural dwellers commonly have fewer financial resources than urban dwellers and are often stereotyped as fatalistic about health. We examined whether fatalism mediates the association of financial status with cardiovascular disease (CVD) self-care in rural adults in economically distressed areas. We hypothesized that those with fewer financial resources would have poorer self-care, and fatalism would mediate this relationship.
Methods: We enrolled 1,122 adults (53 ± 15 years) at risk for CVD. Financial status was reflected by individuals’ perceptions of how well they made “ends meet” with their financial resources, fatalism …
Fully Differential Studies On Dissociative Capture In P + D2 Collisions And On Ionization In P + He Collisions, Shruti Majumdar
Fully Differential Studies On Dissociative Capture In P + D2 Collisions And On Ionization In P + He Collisions, Shruti Majumdar
Doctoral Dissertations
Advancing our understanding of few-body dynamics in simple atomic systems is a fundamental objective in atomic scattering research. The underlying problem is that the Schrödinger equation is not analytically solvable for more than two mutually interacting particles. This involves a comprehensive exploration of various channels, such as ionization, capture, and excitation. A common theoretical approach to describe ion-atom collisions is based on perturbation theory, where the scattering amplitude is expanded in powers of the interaction potential. Here, understanding the few-body problem means accurately describing the relative importance of the higher- vs the first order terms.
In the case of ionization, …
Strontium Titanate For Capacitor And Energy Storage Applications At Cryogenic Temperatures, Hung Trinh
Strontium Titanate For Capacitor And Energy Storage Applications At Cryogenic Temperatures, Hung Trinh
Doctoral Dissertations
This study investigates the dielectric properties of single crystal and ceramic strontium titanate (SrTiO3) for cryogenic capacitor applications from room temperature to 4 K. Permittivity (k) and loss tangent are dependent on temperature, frequency, mechanical stress, and applied DC electric field. Accordingly, the dielectric constant and loss tangent were measured at various frequencies and DC bias levels. Loss tangent data are also presented as equivalent series resistance (ESR). For single crystal SrTiO3, an impurity level of ≈500 ppm barium resulted in an increase of the maximum permittivity to approximately 50,000 at 6 K. This relatively high …
Picture Frame, Bryan Wang
Where I'M From, Kenneth Chapman
Fear, Gwen Keely
A One Woman Voyage, Annabelle Rafferty
Justifying The Fourth Amendment, Daniel Epps
Justifying The Fourth Amendment, Daniel Epps
Vanderbilt Law Review
Why does the Fourth Amendment belong in the Constitution? This question is not whether society should impose some legal restraints on government searches and seizures. Rather, why should such protections reside in our national charter, superior to other forms of law and insulated from change via ordinary majoritarian political processes? Despite major disputes about the Fourth Amendment's content, Fourth Amendment theorists rarely ask this question. Almost all agree that the Fourth Amendment's constitutional protections are critically important-even if no one can agree exactly what those protections are.
This Article seeks a justification for the Fourth Amendment-the reason why search-and-seizure protections …
The Effects Of Pornography On Romantic Relationships, Jade A. Green
The Effects Of Pornography On Romantic Relationships, Jade A. Green
McNair Scholars Research
This study examined the relationship among pornography use, attitudes toward pornography, and romantic relationship outcomes among adults in the United States. The hypotheses are as follows: 1. Pornography use is negatively associated with relationship satisfaction. 2. Positive attitudes toward pornography are negatively associated with relationship satisfaction. 3. Men will report more positive attitudes toward pornography than women, 4. Higher pornography use is associated with being single. A convenience sample of 165 adults from central Arkansas completed measures assessing pornography use/acceptance and relationship satisfaction. Statistical analyses included a correlation matrix, an independent-samples t-test, and a chi-square analysis. Results showed that pornography …
Cybersecurity Risk Shifting, Deborah R. Farringer
Cybersecurity Risk Shifting, Deborah R. Farringer
Law Faculty Scholarship
This article analyzes the growing problem of ransomware attacks in the healthcare sector and evaluates the evolving legal frameworks used to address cybersecurity risks affecting patient data. The authors trace the rapid increase in ransomware incidents, driven in part by the rise of digital health records and cryptocurrency-enabled extortion, and highlight the significant operational and privacy harms resulting from such attacks. The article critically examines existing federal and state legal mechanisms—including statutes such as HIPAA, criminal fraud provisions, and emerging state-level immunity laws—and argues that current approaches are insufficient due to jurisdictional challenges, particularly the transnational nature of cybercrime and …
Micrornas Regulated By Pregnancy Target Antiviral And Cancer Immunity Overlapping With The Hiv Interactome, Paula F. T. Cezar-De-Mello, Jonathan M. Dreyfuss, Pai-Lien Chen, Hidemi Yamamoto, Xiaoming Gao, Hui Pan, Charles Morrison, Gustavo F. Doncel, Robert L. Barbieri, Raina N. Fichorova
Micrornas Regulated By Pregnancy Target Antiviral And Cancer Immunity Overlapping With The Hiv Interactome, Paula F. T. Cezar-De-Mello, Jonathan M. Dreyfuss, Pai-Lien Chen, Hidemi Yamamoto, Xiaoming Gao, Hui Pan, Charles Morrison, Gustavo F. Doncel, Robert L. Barbieri, Raina N. Fichorova
CONRAD Publications
Innate immunity predictors of HIV-1 risk and pathogenesis vary with reproductive hormones, pregnancy, and lactation, yet the underlying mechanisms remain unclear. We hypothesized that pregnancy-associated physiological adaptations alter systemic microRNA (miRNA) expression, thereby regulating immunity, pathogenesis and susceptibility to infection. We analyzed 174 serum samples from 88 participants in a longitudinal cohort from Uganda and Zimbabwe across pre-pregnancy (PP), pregnancy (P), and postpartum breastfeeding (BF). Cell-free peripheral blood miRNAs (n = 2083) were profiled using HTG EdgeSeq. Pregnancy-specific miRNAs were identified by intersecting differentially expressed (DE) miRNAs from P vs. PP and P vs. BF comparisons. miRNA targets and pathways …
Quantification Of Pollutant Re-Introduction Through Ventilation Openings Into A Building: A Benchmark Based On Wind-Tunnel Experiments, Romain Guichard, Anjali Krishnan Radhakrishnan Jayakumari, Stefanie Gillmeier, Ali Bahloul
Quantification Of Pollutant Re-Introduction Through Ventilation Openings Into A Building: A Benchmark Based On Wind-Tunnel Experiments, Romain Guichard, Anjali Krishnan Radhakrishnan Jayakumari, Stefanie Gillmeier, Ali Bahloul
Études primaires
In occupational risk prevention, collective protection measures based on ventilation to reduce exposure to chemical hazards generally consist of containing a pollutant at its source, capturing it, and releasing it outdoors, after purification when it is applicable. However, unfiltered pollutants that are released can be re-introduced through ventilation air intakes or windows of the same building or neighbouring buildings, depending on wind conditions. Predicting the amount of pollutant re-introduced remains very challenging while essential to implement appropriate risk control measures. In this context, an experimental benchmark has been designed to quantify the dispersion and re-introduction of a pollutant in a …
Managing Deportation: How Docket Control Replaced Substantive Relief In Immigration Courts, R. Linus Chan
Managing Deportation: How Docket Control Replaced Substantive Relief In Immigration Courts, R. Linus Chan
SMU Law Review
In the modern deportation era, immigration courts saw their ability to grant relief from deportation undergo significant restrictions, constraining individualized discretion in favor of "categorical" denials. Congress dramatically curtailed the discretionary tools available to immigration judges, with the latest being the pair of immigration reforms from 1996, shifting the locus of individualized decision-making away from the courts and toward enforcement officers and prosecutors. Immigration courts lost discretion in being able to decide who could formally be granted status and stay in the United States when facing deportation through various restrictive eligibility requirements written into the law.
This Article argues that …
Fda After Loper Bright, Erika Lietzan
Fda After Loper Bright, Erika Lietzan
SMU Law Review
Loper Bright Enterprises v. Raimondo, which overruled the Chevron, U.S.A. v. Natural Resources Defense Council decision from 1984, tells us that a court should determine the meaning of all statutory provisions for itself, rather than deferring to the views of the federal agencies that implement those provisions. But the overruling of Chevron may have less of an impact on the U.S. Food and Drug Administration (FDA) than conventional wisdom supposes. Most challenges to FDA action do not concern its statutory interpretations. And the agency prevailed in most cases involving statutory interpretation before the Chevron doctrine took hold. After 1984, …
Juegos De Rol Para Colaboraciones De Investigación Interdisciplinar, Sarah Lynne Bowman, Josefin Westborg, Cristo Leon, Antonio Luis Casado Da Rocha, Esteban Etxeberria
Juegos De Rol Para Colaboraciones De Investigación Interdisciplinar, Sarah Lynne Bowman, Josefin Westborg, Cristo Leon, Antonio Luis Casado Da Rocha, Esteban Etxeberria
STEM for Success Resources
Juegos de rol para colaboraciones de investigación interdisciplinar presenta los juegos de rol como una herramienta formativa para fortalecer la colaboración en equipos de investigación interdisciplinaria. La obra explica cómo el role-playing puede ayudar a desarrollar competencias comunicativas, reflexivas y organizativas necesarias para trabajar entre disciplinas, especialmente en contextos académicos donde los problemas complejos requieren coordinación, negociación de saberes y construcción compartida de conocimiento. Esta traducción al español amplía el acceso a un enfoque innovador para universidades, centros de investigación, facilitadores, docentes y equipos interesados en mejorar sus prácticas colaborativas mediante metodologías participativas, experienciales y orientadas a la investigación. Libro …
Comparison Of Enrichment Interaction Duration Between Male And Female Panthera Leo Leo, Maegen G. Meldrum
Comparison Of Enrichment Interaction Duration Between Male And Female Panthera Leo Leo, Maegen G. Meldrum
Undergraduate Honors Thesis Projects
African lion (Panthera leo leo) populations have declined significantly over the past century within their natural habitats, increasing the importance of effective management strategies for individuals in human care. Environment enrichment is a critical tool for promoting species typical behavior in human care; however, enrichment practices are often generalized and may not account for sex-specific differences. This study examined how sex, enrichment types, behaviors, and time of day influenced enrichment interaction duration in a small pride of African lions (n = 4) housed at the Columbus Zoo and Aquarium. Two enrichment types were evaluated: cognitive/occupational (CO, a manipulable barrel) …
Ruth Fine: In Search Of The Place, Carrie Robbins, Maggie North
Ruth Fine: In Search Of The Place, Carrie Robbins, Maggie North
Books, pamphlets, catalogues, and scrapbooks
This catalogue was published in conjunction with the exhibition Ruth Fine: In Search of the Place, on view in Bryn Mawr College's 1912 Gallery from August 27–December 18, 2026. The exhibition explores Philadelphia-based artist Ruth Fine's longstanding engagement with the natural world in terms of her "search for the place," an approach to artmaking that invites close looking and collaboration. The catalogue was edited by Maggie North and Carrie Robbins and designed by Nathanael Roesch. It also includes contributions from Wendy Edwards, Ruth Fine, Marianne Hansen, Janelle Rebel, and Chloe Sun.
Artificial Intelligence And Mental Health: Promise, Pitfalls And Ethical Priorities, Maharaj Singh
Artificial Intelligence And Mental Health: Promise, Pitfalls And Ethical Priorities, Maharaj Singh
College of Nursing Faculty Research and Publications
Mental health conditions are prevalent across the lifespan, yet workforce shortages, long waiting times, and fragmented systems mean many people never receive timely, evidence‑based care. Artificial intelligence (AI), including machine‑learning classifiers and large language models (LLMs), is being explored to support earlier detection, closer symptom monitoring and scalable psychoeducation. Early studies suggest AI can surface risk signals from language, sleep/activity traces and clinical notes; summarise complex records for clinicians; and deliver structured self‑help at scale. At the same time, safety, bias, privacy and accountability concerns remain salient.
Tick Lipocalin Triggers Mammalian Igfbp-3-Mediated Apoptosis In Macrophages And Keratinocytes, Krittika Nandy, P. P. Mahesh, Lichao Liu, Daniel E. Sonenshine, Hameeda Sultana, Girish Neelakanta
Tick Lipocalin Triggers Mammalian Igfbp-3-Mediated Apoptosis In Macrophages And Keratinocytes, Krittika Nandy, P. P. Mahesh, Lichao Liu, Daniel E. Sonenshine, Hameeda Sultana, Girish Neelakanta
Biological Sciences Faculty Publications
Ticks secrete several molecules, including lipocalins, in their saliva during blood feeding on a vertebrate host. In this study, we provide novel evidence on the role of Ornithodoros turicata americanus tick lipocalin (Otlip) in modulating cytokine expression and in triggering apoptosis in mammalian macrophages and keratinocytes. The cytokine array analysis revealed significantly increased secretion of insulin-like growth factor-binding protein 3 (IGFBP3) from murine macrophage cell line upon treatment with recombinant Otlip protein (rGST-Otlip) when compared to the secretion noted from cells treated with a control protein (rGST). Similar observation with cytokine protein array analysis was noted when murine macrophages were …
Microarray Analysis Of Human Abdominal Aortic Aneurysm With Emphasis On Cardiovascular Genes Revealed Differentially Expressed Genes, Song Lu, Li Ping Li, John V. White, Xiaoying Zhang, Ifeyinwa Nwaneshiudu, Adaobi Nwaneshiudu, Nectaria Ntaoula, John Gaughan, Dimitri S. Monos, Wan-Lu Lin, Charalambos C. Solomides, Emilia L. Oleszak, Chris D. Platsoucas
Microarray Analysis Of Human Abdominal Aortic Aneurysm With Emphasis On Cardiovascular Genes Revealed Differentially Expressed Genes, Song Lu, Li Ping Li, John V. White, Xiaoying Zhang, Ifeyinwa Nwaneshiudu, Adaobi Nwaneshiudu, Nectaria Ntaoula, John Gaughan, Dimitri S. Monos, Wan-Lu Lin, Charalambos C. Solomides, Emilia L. Oleszak, Chris D. Platsoucas
Biological Sciences Faculty Publications
Background/Aim: We examined gene expression profiles in abdominal aortic aneurysm (AAA) lesions vs. normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR).
Materials and Methods: Phosphorus (32P)-labeled cDNA from AAA specimens (mean AAA size 6.65 cm) and normal aortas were hybridized with a 588-gene microarray primarily of the cardiovascular system. The results were validated by qRT-PCR.
Results: A total of 35 out of the 588 genes were differentially expressed, with either log2 ratio of AAAs/controls ≥1 (upregulated; 20 genes) or ≤−1 (downregulated; 15 genes) in AAA lesions vs. normal aorta, and 25 of these were significantly …