Digital Commons Network^™

Optimizing Proaftn Classifier With Ant Colony Algorithm: Enhanced Diabetes Detection Benchmarking, Feras Al-Obeidat

All Works

The increasing global prevalence of diabetes highlights the need for accurate diagnostic tools to improve early detection and effective treatment planning. Traditional classification models often struggle to achieve optimal performance due to limitations in parameter tuning and adaptability to complex datasets. To address these limitations, this article introduces PROAnt, an innovative learning approach designed to enhance the robustness and efficiency of the PROAFTN multicriteria classification method. PROAnt leverages the computational power of ant colony optimization (ACO) to dynamically fine-tune and optimize the key parameters, such as intervals and weights, at the core of the PROAFTN classification process. This learning methodology …

Accurate Chromatin Marks Peak Calling With Omnipeak, Oleg Shpynov, Maxim N Artyomov

2020-Current year OA Pubs

Chromatin immunoprecipitation sequencing (ChIP-seq) is a widely used technique for identifying transcription-factor binding and histone modifications across the genome. Peaks in ChIP-seq data vary in length depending on the biological context, from narrow transcription factor binding sites to broad histone modification domains. However, commonly used peak-calling tools are tailored to the specific types of data and struggle to consistently handle various peak lengths, datasets of varying quality, and missing control tracks-common issues in comparative or meta-analyses. These limitations are addressed with Omnipeak, a universal unsupervised peak-calling algorithm based on a constrained three-state hidden Markov model. Omnipeak accurately models global genomic …

Towards A Unified Gating Scheme For The Cnbd Ion Channel Family, Jenna L Lin, Baron Chanda

2020-Current year OA Pubs

Cyclic nucleotide-binding domain (CNBD) channels are critical components of numerous bioelectrical processes, including cardiac pacemaking, neuronal signaling, phototransduction in the eye, and stomatal regulation in plants. While members of this channel family share a conserved overall structure, they exhibit striking differences in voltage sensitivity. Hyperpolarization-activated cyclic nucleotide-gated channels are activated by membrane hyperpolarization, whereas ether-à-go-go channels open upon depolarization. Mutagenesis and chimeragenesis studies have revealed that some mutants display bipolar gating behavior-remaining closed at intermediate membrane potentials but capable of opening in response to both hyperpolarization and depolarization. Remarkably, in certain cases, just a few mutations are sufficient to reverse …

Hybrid Warfare: A Collection Of Scenarios, Adrian Borbély

DRI Press

Hybrid Warfare is nothing new but it has increasingly made the news - even if most of it remains beyond our awareness. Hybrid Warfare gathers all methods through which countries wage war against each other beyond traditional military, diplomatic and economic battlefields (cyber attacks, disinformation, transnational organized crime, appropriation of natural resources, lawfare, corruption, etc.). Such below-the-surface foreign aggressions are not limited to localized regions where armed forces shoot at each other trying to take each other’s positions. In hybrid warfare, society as a whole is the battlefield. In other words, hybrid warfare is not the concern of a few, …

On The Future Of The Blue Economy: Comparing Indonesia’S Role In The Asean And Lac Regions, Darynaufal Mulyaman, Bambang Dwi Waluyo, Dewi Aulia Maharani

Global: Jurnal Politik Internasional

This study aims to determine the concrete development and implementation of blue economy programs in the future by examining Indonesia's role in the context of international political economy, particularly through maritime diplomacy and cross-regional cooperation such as ASEAN, the Indonesia-Latin America and Caribbean Business Forum INA-LAC, and the Alliance of Island States AIS. Using a constructivist approach, this study concludes that Indonesia, as a middle-power country, utilises soft resources, such as maritime identity, sustainability values, and diplomatic leadership, to strengthen its position in global blue economy governance. The results of the study show that Indonesia has strategic potential for developing …

From Local To Global: Surabaya’S Paradiplomacy Strategy In Realising A Child-Friendly City, Muhammad Fajhriyadi Hastira, Ali Maksum, Muh Fichriyadi Hastira, Ramalina Ranaivo Mikea Manitra

Global: Jurnal Politik Internasional

Along with the development of decentralisation and subnational diplomacy, strengthening child protection at the city level has become an important part of the global agenda. This research aims to analyse the implementation of the Child-Friendly Cities Initiative in Surabaya City from a paradiplomacy perspective. In addition, this study seeks to explain the synergy between local, national, and global policies and identify opportunities and challenges using literature studies and analysis of official documents from the Ministry of Women's Empowerment and Child Protection (PPPA) and the Surabaya Office of Women's Empowerment, Child Protection, Population Control, and Family Planning (P3APPKB), the Surabaya City …

Ulama And Vision 2030: Saudi Arabia Government's Strategies To Navigate A Successful Economic Reform, Nashiha Ulya, Hamdan Basyar

Global: Jurnal Politik Internasional

Saudi Arabia's Vision 2030 seeks to diversify its oil-dependent economy, but scepticism persists due to past reform failures, particularly in fiscal policy and labour markets. Ulama, as key figures in the Saudi "social contract," play a vital role in legitimising government policies, especially on social and religious matters. However, reforms promoting private sector growth and social liberalisation have raised concerns among conservative ulama over potential threats to Islamic values. To address this, the government under Mohammed bin Salman (MBS) employs a strategy of separating economic and religious narratives while using a "carrot and stick" approach to manage ulama opposition. This …

The Regionalisation Of Blockchain Technology As Asean Cybersecurity Strategy Against Terrorist Financing Through Cryptocurrency, Sabda Ningsih, Syuryansyah Syuryansyah

Global: Jurnal Politik Internasional

Through this study, the authors question how the prospects for ASEAN regionalisation relate to the development of blockchain technology as a cybersecurity medium. Based on previous research, ASEAN is facing a problem of terrorism, which is difficult to handle over time. The finding further exacerbates the fact that transnational terrorist groups have begun to use virtual currency as one of their strategies for funding organisations. Meanwhile, Southeast Asia, according to results of several surveys, includes areas with high numbers of cryptocurrency users, making it a target for blockchain technology companies to establish main offices. Within the framework of ASEAN regionalism, …

Forecasting Budget Requirement For Indonesian Arms Modernisation With International Cost Escalation (Ice), Curie Maharani, Reyhan Noor, Sandy J. Pratama, Ganesh A. Wicaksono

Global: Jurnal Politik Internasional

In 2021, the question "How much is enough" emerged in national debate following the plan of the then Indonesian Defence Minister, Prabowo Subianto, to allocate 1.7 quadrillion Rupiah for military modernisation from 2020 to 2045. This article follows up on this debate by recommending a budget forecasting model for the weapons acquisition requirements of the Indonesian National Defence Forces (TNI) during the period 2025 to 2044. The model is built by considering International Cost Escalation (ICE), which is the increase in the unit cost of successive generations of similar weapons, causing a steady increase in the price of weapons systems …

From Compliance To Care: Reconstructing Feminist Accountability In Global Aid Governance, Andi Pangeran, Ani Widyani Soetjipto, Shelly Adelina

Global: Jurnal Politik Internasional

This article critically examines the literature on global aid governance through a feminist lens, focusing on three key areas: epistemic power, organisational depoliticisation, and the ethics of accountability. The review reveals that the coloniality of knowledge in global aid governance creates epistemic hierarchies grounded in claims of objectivity and efficiency, thereby marginalising local voices. Meanwhile, processes such as NGO-isation and professionalisation have transformed activism into administrative compliance. However, within these structures, reflective agency can still emerge through negotiated autonomy and the politics of translation, allowing feminist organisations to maintain their political significance. Regarding ethics, feminist accountability is redefined as a …

Conclusions Are Not Supported By The Published Statistical Analysis Comment On López-Toledo Et Al Flaxseed Improves Glucose And Lipid Metabolism In Mexican Subjects With Type 2 Diabetes: A Parallel Randomized Clinical Trial, Robert W Spitz, Deependra K Thapa, Thirupathi Reddy Mokalla, Wasiuddin Najam, Andrew W Brown, David B Allison

Children’s Nutrition Research Center Staff Publications

López-Toledo et al [...].

International Guidelines On The Diagnosis And Treatment Of Nut Carcinoma, Yu Zhang, Qi Zhang, Yue Hao, Jia Luo, Yingshi Piao, Zhengbo Song, Luka Brcic, Aijun Liu, Jinpu Yu, Yasuhiro Tsutani, Wenzhao Zhong, Wenfeng Fang, Zhijie Wang, Shengxiang Ren, Athanasios G Papavassiliou, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Ayten Kayi Cangir, Anwen Liu, Wen Li, Filippo Lococo, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Helmut Popper, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Kalevi Kairemo, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Ashrafian Leanne, Xiaoyan Li, Chuanhao Tang, Hifzur R Siddique, Chengzhi Zhou, Junping Zhang, Junli Xue, Vishal Shelat, Hui Guo, Qian Chu, Rui Meng, Fatemeh Ardeshir, Jingxun Wu, Rui Zhang, Jin Zhou, Robert A Kratzke, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Fiorella Calabrese, Yang Xia, Alessandro Wasum Mariani, Yuanyuan Lu, Xiaofeng Chen, Mark A Klein, Rui Ge, Enyong Dai, Axel H Schönthal, Yu Han, Zhenying Guo, Jian Zhang, Yinghua Ji, Xianbin Liang, Hongmei Zhang, Xuelei Ma, Marco Chiappetta, Xuewen Liu, Francoise Galateau Salle, Yu Yao, Malgorzata Szolkowska, Weiwei Pan, Fei Pang, Fan Wu, Stefan B Watzka, Liping Wang, Youcai Zhu, Li Lin, Aparna Sharma, Jianfei Tu, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Marjorie G Zauderer, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Elizabeth Dudnik, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Binbin Song, Wenfeng Li, Jianfei Fu, Marina K Baine, Pingli Sun, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Jing Wu, Yunyun Yang, Yuan Fang, Zhen Wang, Bin Wan, Donglai Lv, Huafei Chen, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Mohamed Emam Sobeih, Bihui Li, Bin Lian, Lili Mao, Zhang Zhang, Ke Wang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Xiaobing Chen, Gu Jin, Miao Li, Guansong Wang, Thomas U Marron, Jiandong Wang, Sanjay Popat, Meiyu Fang, Yong Fang, Daniel Mansilla, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Aaron S Mansfield, Biyun Wang, Lu Si, Anja C Roden, Bjørn H Grønberg, Yong Song, Geoffrey I Shapiro, Christopher A French, Yuanzhi Lu, Qian Wang, Chunwei Xu

Faculty, Staff and Student Publications

Nuclear protein in testis (NUT) carcinoma (NC) represents a rare, clinically aggressive cancer defined by pathognomonic NUT Midline Carcinoma Family Member 1 (NUTM1) gene fusions, with bromodomain and extraterminal domain (BET) protein 4 (BRD4)-NUTM1 being the predominant oncogenic driver. Since its description in 1991, gradual advances have clarified the pathologic mechanisms of NC and its diagnostic methods; however, NC treatment remains a significant challenge. Moreover, diagnostic and treatment approaches for this cancer require further validation and standardization. These guidelines were developed by the Chinese Alliance of Research for NC (ChARN) based on current evidence in …

A Prognostic Matrix Gene Expression Signature Defines Functional Glioblastoma Phenotypes And Niches, Monika Vishnoi, Zeynep Dereli, Zheng Yin, Elisabeth K Kong, Meric Kinali, Ozgun Babur, Nourhan Abdelfattah, Xubin Li, Behnaz Bozorgui, Mary C Farach-Carson, Robert C Rostomily, Anil Korkut

Faculty, Staff and Student Publications

Interactions among tumor, immune, and vascular niches play major roles in glioblastoma (GBM) malignancy and treatment responses. The composition and heterogeneity of extracellular core matrix proteins (CMPs) that mediate such interactions are not well understood. Here, we present an analysis of the clinical relevance of CMP expression in GBM at bulk, single-cell, and spatial anatomical resolution. We show that CMP enrichment is associated with worse patient survival, specific driver oncogenic alterations, mesenchymal state, pro-tumor immune infiltration, and immune checkpoint expression. Matrisome expression is enriched in vascular and leading edge/infiltrative niches that are known to harbor glioma stem cells. Finally, we …

Precision Targeting Of Sting: Challenges, Innovations, And Clinical Outlook For Cancer Therapy, Jiaqi Shi, Yingying Zhang, Na Zhao, Ekihiro Seki, Li Ma, Xiaobo Li, Tongsen Zheng

Faculty, Staff and Student Publications

The stimulator of interferon genes (STING) pathway plays a crucial role in immune responses and has emerged as a compelling target in cancer therapy. Despite promising preclinical studies, clinical trials of STING agonists have largely failed to deliver durable efficacy, with no agents progressing to phase III trials. This review examines the biological, pharmacological, and clinical barriers limiting STING pathway activation in cancer treatment. We discuss the inherent limitations of STING agonists as well as host-related resistance driven by tumor heterogeneity, immune suppression, and chronic STING activation. Mechanisms of acquired resistance, such as immune checkpoint upregulation and suppression of effector …

Statistics Of Glinting Clouds Observed By Dscovr And Geostationary Satellites, Tamás Várnai, Alexander Marshak, Alexander Kostinski

Michigan Tech Publications

This study examines how frequently the specular reflection of sunlight—that is, sun glint—reveals the presence of ice crystals that maintain a steady horizontal orientation. The study analyzes data from the Earth Polychromatic Imaging Camera (EPIC) onboard the Deep Space Climate Observatory (DSCOVR) spacecraft and from collocated images taken by geostationary satellites. The analysis of spatio-temporal variations in glint frequency over vegetated land surfaces reveals that (a) year-to-year variations are modest with no clear trends; (b) glints typically occur 7%–8% more frequently than previously estimated; (c) glints are most frequently observed during the May-August period, and over Asia. The results also …

Xenobot-Inspired Diatom Analogues For Synthetic Kinematic Renewal Of Regenerative Nanobot Payloads, Suma Mallapragada, Vaishnavi Sankepally, Anishkumar Manoharan, Muhamed Fazl, Cherukuri Dhawal, Shreya Abhijit Patki, Kethavarapu Uma Eswar Datta Sai

Defensive Publications Series

A system and method are presented for a time-bounded, non-genetic regeneration framework in which synthetic, diatom-shaped functional organelles are continuously produced, deployed, and exhausted within a confined system. The approach relies on geometry-driven kinematic assembly, droplet and gel physics, and swarm-level population homeostasis rather than cellular replication or organism growth. A critical design invariant enforces the release of exactly two functional organelles per release event, ensuring bounded output, predictable dynamics, and safety. The disclosure provides laboratory-recognizable implementation pathways suitable for materials science, soft-matter physics, and bioengineering groups and is released for public use to establish prior art.

Staff Education Project For Nursing Staff At An Adult Mental Health Clinic To Address Inconsistencies And Inadequacies In Suicide Risk Screening, Grace Oluwasade Awodele

Walden Dissertations and Doctoral Studies

This staff education initiative was designed for nursing personnel at an adult mental health clinic, aiming to address inconsistencies and inadequacies in suicide risk screening practices among health care providers. Despite regular patient interactions, staff frequently lack the necessary knowledge, confidence, and standardized tools to identify individuals at risk for suicide, leading to missed opportunities for early intervention. The existing gap in practice jeopardized patient safety, led to preventable harm, and highlighted the need for evidence-based screening protocols, such as the Ask Suicide-Screening Questions (ASQ) tool, to facilitate timely, equitable, and effective suicide prevention in nursing practice. The project focused …

Perceptions Of Juvenile Justice Professionals Regarding The Effectiveness Of Juvenile Reentry Programs And Recidivism In The Southwest Region, Lei Anne Johnson

Walden Dissertations and Doctoral Studies

Juvenile recidivism persists in the U.S. justice system, highlighting the need for effective reentry programs. However, limited research exists on juvenile justice professionals’ perceptions of program success. The purpose of this qualitative study was to explore these professionals’ perceptions regarding the effectiveness of juvenile reentry programs in reducing recidivism. Guided by Bandura’s social learning theory, the study examined how observation and modeling influence youth behavior during reentry. The research questions focused on professionals’ perceptions of program effectiveness and how these perceptions impact recidivism reduction efforts. A qualitative phenomenological design involved semi-structured interviews with 13 juvenile justice professionals in the southwest …

Circumciser Type And The Type Of Female Genital Mutilation/Cutting Prevalence For Girls Ages 0-14 Years In Ethiopia, Jean-Pierre Ramazani Abedi

Walden Dissertations and Doctoral Studies

Despite ongoing eradication efforts, female genital mutilation and cutting (FGM/C) remains a major public health and human rights concern in Ethiopia. This quantitative study was conducted to examine how circumciser type (traditional cutter, birth attendant, or health professional) influences FGM/C prevalence and severity among girls ages 0–14, considering the moderating effects of residence and mothers’ FGM status, while controlling for age and income. Guided by the social ecological model and using 2016 E Ethiopian Demographic Health Surveys data, analysis indicates a significant association between circumciser type and FGM/C type (χ² (2, N = 1,553) = 6.86, p = .032), which …

Staff Education To Improve Patient Safety Using Standardized Medication Transcription Verification, Beloved Martey

Walden Dissertations and Doctoral Studies

This staff education project was a quality improvement initiative aimed at reducing medication transcription errors by implementing a standardized verification protocol. The project addressed the critical practice problem of transcription-related medication errors, which contribute to wrong medication administration, adverse drug events, and patient harm. The practice-focused question was: How does implementing a staff education program on standardized medication transcription verification processes in healthcare institutions affect the rate of wrong medication administration compared to traditional transcription methods without education? The project was implemented over 8 weeks in an outpatient clinic with 20 participants (8 prescribers and 12 nurses). The primary data …

Teachers’ Experiences With The Use Of Read-Alouds For Fourth- And Fifth-Grade Students, Shervita Bryant

Walden Dissertations and Doctoral Studies

The research problem addressed in this basic qualitative study was the inconsistent use and implementation of teacher read-alouds among fourth- and fifth-grade teachers in an urban district. Guided by Clark and Peterson’s cognitive process teacher model, Rumelhart’s schema theory, and Gough and Tunmer’s simple view of reading, the purpose of this project study was to explore teachers’ experiences and perceptions regarding their use of read-alouds as part of their regular reading instruction. Two research questions were developed to explore teachers’ experiences of the support received for using the read-aloud. Semistructured interviews were conducted with 10 fourth- and fifth-grade teachers. Data …

Novice Middle Grades Science Teacher Perspectives On Culturally Responsive Teaching Practices, Erica Danielle Benjamin Williams

Walden Dissertations and Doctoral Studies

Culturally responsive teaching (CRT) bridges students’ cultural experiences with academic learning; however, novice science teachers often lack the preparation to apply it. This study addressed the problem that teachers without sufficient preparation to support culturally diverse learners are teaching middle grades science. Grounded in Freire’s critical consciousness and informed by Gay’s CRT principles, the purpose of this study was to explore the experiences and perspectives of middle grades science teachers in their first 5 years of teaching regarding their use of CRT to plan and implement science lessons. Data from 12 semistructured interviews with novice middle grades science teachers were …

Strategies To Manage Business Process Outsourcing Initiatives, Zienisha Bailey-Grant

Walden Dissertations and Doctoral Studies

Organizations increasingly rely on business process outsourcing (BPO) to reduce costs, access specialized expertise, and improve efficiency; however, failure rates in BPO initiatives remain high, leading to financial loss, operational disruptions, and reduced competitiveness. Business leaders who lack effective strategies to manage outsourcing projects risk eroding customer satisfaction and organizational performance. Grounded in transaction cost economics and the resource-based view, the purpose of this qualitative single-case study was to explore strategies some business leaders used to successfully manage BPO initiatives. The participants included 10 senior managers from organizations in the southeastern United States who had demonstrated success in overseeing outsourcing …

Racial And Ethnic Minority Supervisees’ Experiences In Clinical Supervision, Destiny Chanel Hill

Walden Dissertations and Doctoral Studies

Clinical supervision practices, although essential to counselor development, often reflect limited cultural competence among supervisors contributes to unclear expectations, conflicting roles, and isolation, leading to stress, negative internalization, and compromised professional development. The purpose of this hermeneutic phenomenological study was to explore the lived experiences of racial and ethnic minority supervisees in clinical supervision within the mental health counseling profession. The research question was: What are the lived experiences of racial and ethnic minority supervisees who have been involved in clinical supervision? The framework guiding the study was hermeneutic phenomenology. Data from interviews with eight participants were analyzed using the …

Environmental Enteric Dysfunction In Well-Nourished And Undernourished Women In Bangladesh, Mustafa Mahfuz, Md Shabab Hossain, Ar-Rafi Khan, Mehjabin Tishan Mahfuz, Rumana Sharmin, A H M Rezwan, Musarrat Tasnim, S M Tafsir Hasan, S M Khodeza Nahar Begum, M Masudur Rahman, Michael J Barratt, Jeffrey I Gordon, Tahmeed Ahmed

2020-Current year OA Pubs

INTRODUCTION: Environmental Enteric Dysfunction (EED) is a subacute inflammation of the small intestinal (SI) mucosa associated with undernutrition and perturbation of the SI microbiota. Its diagnosis relies on histopathological assessment of small intestinal biopsies, with a lack of validated biomarkers contributing to underdiagnosis. This study assessed the prevalence and histological features of EED in undernourished Bangladeshi women living in an urban slum in Dhaka, compared to well-nourished women from slum and non-slum areas, and examined the factors associated with histologically confirmed EED.

METHODS: This analysis included non-pregnant, non-lactating Bangladeshi women aged 18-45 years classified by location of residence and nutritional …

Reviewing Crowdsourcing And Community Engagement In Museums, Paul Longley Arthur, Lydia Hearn, Isabel Smith

Research outputs 2022 to 2026

Over the past two decades, museums have increasingly experimented with digital technologies to connect with broader contemporary culture. This review article investigates the role crowdsourcing can play in transforming museums into more engaged environments, raising visibility and inclusivity, and involving diverse voices and populations in knowledge-creation processes. Its contribution is to provide an overview of the history, definitions and concepts of crowdsourcing, and examples of crowdsourcing policies and practices that have been adopted by museums. Participation in crowdsourcing has been influenced by gender, education, and socio-economic and cultural background. In the past, historical structures and traditions and infrastructural complexities have …

Omg! A Proteomic Determinant Of Neurodegenerative Resiliency, Michael R Duggan, Muhammad Ali, Menghan Liu, Ying Xu, Daniel Western, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

BACKGROUND: Biofluid proteomics can enhance our understanding of the neurodegenerative mechanisms underlying Alzheimer's disease and related dementias (ADRDs). Oligodendrocyte myelin glycoprotein (OMG) is a brain-specific protein implicated in myelination, but its potential mechanistic, biomarker, and therapeutic roles in ADRDs requires further elucidation.

METHODS: After detecting an inverse association between its abundance in peripheral circulation and cortical amyloid deposition in two community-based cohorts, the current study characterized OMG's role in ADRDs with high-throughput proteomics from sixteen independent cohorts. Data included a variety of cross-sectional and longitudinal community-based and clinical cohorts from North America, Europe, and Asia, and incorporated complementary biofluids, biospecimens, …

Performance Of A Rapid, Highly Multiplexed Nucleic Acid Detection Assay For Identification Of Viral And Bacterial Pathogens From Upper Respiratory Tract Specimens

Faculty, Staff and Students Publications

Background: Accurate and timely identification of upper respiratory tract pathogens can improve patient management by decreasing unnecessary additional testing, reducing the cost of care, and informing antimicrobial stewardship. We evaluated the FDA-cleared Diasorin LIAISON PLEX® Respiratory Flex (RSP Flex), a highly multiplexed, rapid nucleic acid detection assay that can identify 14 viral and 5 bacterial respiratory pathogens.

Methods: In total, 215 residual patient upper respiratory tract specimens were tested using the RSP Flex assay and results compared to standard-of-care (SOC) molecular testing.

Results: Positive percentage agreement (PPA) was 100% for the following targets: adenovirus, human coronavirus, Bordetella pertussis, Bordetella parapertussis, …

System And Method For Autonomous Cross-Domain Collaborative Artificial Intelligence–Driven Discovery And Innovation, Chiranthan N

Defensive Publications Series

The presented proposal discloses a system and method for autonomous, collaborative artificial intelligence–driven discovery and innovation. The techniques presented herein enables structured interaction among multiple specialized AI software agents, each possessing domain-specific expertise, to perform real-time cross-domain reasoning without continuous human intervention. An interaction controller governs communication, reasoning exchange, and collaboration rules among the agents, while an evaluation module assesses novelty, feasibility, and domain validity of generated outputs. Through iterative feedback and refinement, the proposed system synthesizes knowledge across disciplines to generate robust, non-obvious solutions and inventive outcomes. The proposed architecture overcomes limitations of conventional single-domain and task-parallel AI systems …

Emergent Bias And Fairness In Multi-Agent Decision Systems, Maeve Una Madigan, Stuart Burrell, Kamalaruban Parameswaran, Glenn Moynihan, David Sutton

Defensive Publications Series

The present subject matter relates to a systematic study of emergent bias and fairness dynamics in multi-agent LLMdecision making. In particular, the present disclosure compares single-agent performance with memory-based and collective refinement multi-agent discussion paradigms across a suite of group fairness metrics on tabular datasets with sensitive attributes. Across settings, fairness changes from multi-agent collaboration relative to single-agent baselines are typically concentrated around small negative values or near zero, indicating that bias is most often only marginally reduced or remains unchanged, while a thin but long positive tail shows rare cases where multi-agent interaction can substantially worsen bias. These findings …